CN107823621A - A kind of double-formulation controls tinea pedis composition and its application method - Google Patents
A kind of double-formulation controls tinea pedis composition and its application method Download PDFInfo
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- CN107823621A CN107823621A CN201711353235.9A CN201711353235A CN107823621A CN 107823621 A CN107823621 A CN 107823621A CN 201711353235 A CN201711353235 A CN 201711353235A CN 107823621 A CN107823621 A CN 107823621A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Abstract
The invention discloses a kind of double-formulation to control tinea pedis composition, including first containing chlorine-containing disinfectant dose and second dose containing plants essential oil.By weight percentage, first dose includes following component:Chlorine-containing disinfectant 92.5 95.9%, potassium permanganate 1.1 1.5%, sodium chloride 3 6%;Second dose includes following component:Ginger essential oil 35 40%, wormwood essential oil 13 25%, safflower essential oil 14 20%, Lavender 12 15%, black pepper essential oil 6 7%, Fructus Foeniculi quintessence oil 4 5%.The double-formulation controls tinea pedis composition, first dose can efficiently, quickly treat tinea pedis;Second dose helps out, and while bactericidal antiphlogistic, can stimulate circulation, enhancing foot resistance, reduces the probability recurred again, its Small side effects can be long-term use of;First dose can also carry out disinfection to footgear, solve after treatment by footgear subinfection again, the problem of recurrent exerbation.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and its application method, more particularly to a kind of double-formulation combination for treating tinea pedis
Thing and its application method.
Background technology
" tinea pedis " scientific name tinea pedis, it is the foot dermatosis as caused by pathogenic fungus.There is no sebum between the vola of people and toe
Gland, so as to lack the aliphatic acid for suppressing skin filamentous fungi, physiological defense function is poor, and the sweat gland of skin at these positions is very
It is abundant, perspire relatively more, air circulation is poor in addition, local damp warm, is advantageous to the growth of filamentous fungi.In addition, vola
Area skin cuticula is thicker, and the keratin in cuticula is the abundant nutrition material of fungi, is advantageous to the growth of fungi.Tinea pedis
With very strong infectiousness, and in fact, caused by the patient of the overwhelming majority is due to infection.It is apt to occur in summer, sick in the winter time
Feelings take a turn for the better more.During tinea pedis is fallen ill, patient very itch it is hard to bear, and can with it is local suppurate, red and swollen, pain, influence patient work and
Study.The medicine for treating tinea pedis in the market has many kinds, is broadly divided into two kinds of Traditional-Chinese-medicine-type and Western medicine type.
The medicine of Traditional-Chinese-medicine-type is mainly used as medicine from anti-inflammation, medicinal material promoting blood circulation and removing blood stasis, its Small side effects, but curative effect compared with
Slowly, patient can not often adhere to long-term treatment;Also some curative effect of medication are fast, but easily repeatedly, and repeatedly after treatment, because fungi
Raw drug resistance, curative effect gradually reduce.It is in Western medicine to select antimycotic medicine such as pyroles, more alkenes, echinocandin class etc. more,
Often preceding several times in use, significant effect, but because the residual fungi above such as footgear, often causes tinea pedis recurrent exerbation,
Later stage, curative effect gradually reduced in use, fungi produces drug resistance.
The content of the invention
It is an object of the invention to provide a kind of double-formulation medicine for treating tinea pedis and its application method, first dose of the medicine into
Divide simply, therapeutic effect is notable, quick, and footgear can be carried out disinfection, and recurrence is infected repeatedly now after efficiently solving treatment
As;Second dose of the medicine is plants essential oil, mainly plays auxiliary treatment, and it is mainly using with sterilizing, promoting blood circulationization
The plants essential oil of stasis of blood function, side effect is minimum, can be long-term use of, while treatment, enhances the resistance of foot, improves life
Defensive enginery is managed, reduces the probability recurred again.
To achieve the above object, the present invention adopts the following technical scheme that:
A kind of double-formulation controls tinea pedis composition, including first containing chlorine-containing disinfectant dose and second containing plants essential oil
Agent, it is characterised in that described first dose, by weight percentage, including following component:
Chlorine-containing disinfectant 92.5-95.9%;
Potassium permanganate 1.1-1.5%;
Sodium chloride 3-6%;
Described second dose, by weight percentage, including following component:
As a kind of preferred scheme, described first dose, by weight percentage, including following component:
Chlorine-containing disinfectant:93%;
Potassium permanganate:1.2%;
Sodium chloride:5.8%;
Second dose containing plants essential oil, including following component:
As a kind of preferred scheme, described chlorine-containing disinfectant be sodium hypochlorite, calcium hypochlorite, sodium dichloro cyanurate,
One kind in sym-closene, Efficacious Disinfeitant or oronain T.
As a kind of preferred scheme, described chlorine-containing disinfectant purity is food-grade or medical grade.
As a kind of preferred scheme, available chlorine content is 2 × 10 in the chlorine-containing disinfectant5ppm。
As a kind of preferred scheme, described second dose of plants essential oil is the fourth stage.
It is a further object to provide a kind of method using above-mentioned double-formulation tinea pedis composition, including following step
Suddenly:
40-50 DEG C of warm water is put into tub or pottery pot, the water surface was not had instep;
The volume proportion for measuring first dose, described first dose and water is 1-1.25:1000;
First dose measured is poured into tub or pottery pot, is stirred;
Both feet are put into immersion 3-5 minutes in water;
Water in tub or pottery pot is outwelled and rinsed clean while both feet warm water washing is clean;
40-50 DEG C of warm water is put into tub or pottery pot, the water surface was not had instep;
Second dose of 5-7 drops are added dropwise in per 1000mL water, stir;
Pin is put into immersion 20-30 minutes in water.
As a kind of preferred scheme, the application method is further comprising the steps of:
40-50 DEG C of warm water is put into tub or pottery pot, the water surface was not had footgear surface;
The volume proportion for measuring first dose, described first dose and water is 1.25-1.5:1000;
Chlorine-containing disinfectant is poured into tub or pottery pot, stirred;
Footgear is put into immersion 15-20 minutes in water.
The beneficial effects of the present invention are:
One, is by the present invention in that with double-formulation composition treatment tinea pedis.First dose of main component is chlorine-containing disinfectant, chloride
Disinfectant can kill various microorganisms, including the bacterial spore that bacterial propagule, virus, fungi, tubercle bacillus and drag are most strong.
First dose containing chlorine-containing disinfectant and water are passed through into volume proportion 1-1.25:1000, then both feet are carried out to soak 3-5 points
Clock, it can fast and efficiently kill pathomycete.Potassium permanganate can effectively kill various bacterial propagules, fungi as oxidant
And tubercle bacillus;The higher sodium chloride solution of concentration has larger osmotic pressure, is unfavorable for the survival of bacterium or microorganism, can rise
To antibacterial and certain bactericidal action.Three shares, can efficiently, quickly kill pathomycete.
Two, contain second dose of plants essential oil, from the plants essential oil with disinfection, blood circulation invigorating efficacies, no pair
Effect, can be long-term use of, plays a part of auxiliary treatment., can also relaxing tendons and activating collaterals, enhancing new city generation while disinfection
Thank, stimulate circulation, strengthening the resistance of both feet.
First dose of three, chlorine-containing disinfectants passes through volume proportion 1.25-1.5 with water:1000, then footgear is soaked
15-20 minutes, the microorganism on footgear can quickly, be efficiently killed, after avoiding treatment, be re-infected by wear shoes socks.
Embodiment
The present invention provides a kind of double-formulation and controls tinea pedis composition, including first containing chlorine-containing disinfectant dose and contains plant
Second dose of essential oil, it is characterised in that described first dose, by weight percentage, including following component:
Chlorine-containing disinfectant 92.5-95.9%
Potassium permanganate 1.1-1.5%
Sodium chloride 3-6%
Described second dose, by weight percentage, including following component:
Wherein, chlorine-containing disinfectant:Generation hypochlorous acid can make mycoprotein denaturation, solidification after chlorine-containing disinfectant is dissolved in water, reach
To bactericidal action.In addition, hypochlorous acid generates nascent oxygen in decomposable process, make mycoprotein oxidation Decomposition, destroy thalline
Albumen, chlorine-containing disinfectant are a kind of broad-spectrum disinfectants, have killing action to bacterial propagule, virus, fungi, bacterial spore.
Potassium permanganate:By aoxidizing the active group of thalline, bactericidal action is presented, potassium permanganate can effectively be killed various thin
Bacterium brood body, fungi, tubercle bacillus.
Sodium chloride:The higher sodium chloride solution of concentration has larger osmotic pressure, is unfavorable for the survival of bacterium or microorganism,
Antibacterial and certain bactericidal action can be played.
Chlorine-containing disinfectant, high violent acid value and sodium chloride three share, can efficiently, quickly kill pathomycete.
Ginger essential oil:Contribute to dissipation hemostasis, enhancing metabolism, the effect to stimulate circulation, in the hot water of bubble pin
Instill a few drop ginger essential oils, moreover it is possible to reach the effect for removing tinea pedis foot odour.
Wormwood essential oil:With rationale blood, warm meridians, dispellieg cold and dampness, antibacterial, anti-inflammatory, promote circulation, tonifying Qi, lift immunity
Effect.Be added dropwise essential oil in foot-immersing water, long-term use can tonifying Qi, effectively lift immunity.
Safflower essential oil:Good anti-inflammatory essential oil, there is bactericidal antiphlogistic, rise to body energy effect.
Lavender:With clearing heat and detoxicating, the skin-protecting function such as promotion damaged tissues regeneration recovery.
Black pepper essential oil:Potent antibiotic essential oil, clean-up effect is excellent, can be applied to burn, sore, sunburn, tinea, wart, circle
Tinea, bleb and tinea pedis.Also scalp overdrying and dandruff can be treated.
Fructus Foeniculi quintessence oil:Can with anti-inflammatory, antibacterial, anti-spasm, removing toxic substances, eliminating the phlegm, desinsection, make pathological phenomenon regression, sharp spleen,
Inspire sweat.Also has purification function, so the effectively waste of discharge skin histology only, nourishing function, favourable oiliness, dark and gloomy and wrinkle
Grain leather skin, help extravasated blood blood flow slow.Raise one's spirts and endurance, Rosemary Essence Oil, can avoid infecting disease by other people.
Above-mentioned plants essential oil shares, and each component complements each other, so as to obtain a kind of bactericidal antiphlogistic, promoting blood circulation and removing blood stasis, enhancing
The composition of foot's resistance.
As another embodiment of this case, wherein, described first dose, by weight percentage, including following component:
Chlorine-containing disinfectant:93%
Potassium permanganate:1.2%
Sodium chloride:5.8%
Second dose containing plants essential oil, including following component:
When selected component carries out proportioning combination according to this percentage by weight, the effect for the treatment of tinea pedis well can reach.
As another embodiment of this case, the chlorine-containing disinfectant be sodium hypochlorite, calcium hypochlorite, sodium dichloro cyanurate,
One kind in sym-closene, Efficacious Disinfeitant or oronain T.It is preferred that use sodium hypochlorite, calcium hypochlorite, chlorination tricresyl phosphate
These three inorganic chlorines of sodium.
As another embodiment of this case, the chlorine-containing disinfectant purity is food-grade or medical grade.The hypochlorous acid of technical grade
Sodium contains more impurity, especially containing certain density heavy metal, can penetrate into skin, influence the health of human body.Food
Grade and medical grade sodium hypochlorite purity are high, and content of beary metal is extremely low, to Small side effects caused by human body.
As another embodiment of this case, available chlorine content is 2 × 10 in the chlorine-containing disinfectant5ppm。
According to formula C1V1=C2V2.
Wherein:C1:The concentration of solution before dilution;
C2:The concentration of solution after dilution;
V1:Dilute the volume of money concentrated solution;
V2:The volume of solution after dilution.
Bubble pin institute water requirement generally requires 3000-4000mL, i.e. V2 volumes.Shown according to clinical data, when steeping pin, steep pin
Disinfection Effect is preferable when the effective chlorine density that water contains is 200-250ppm.That is, the available chlorine content of chlorine-containing disinfectant 1-2 ×
105Between ppm.It is volatile because chlorine-containing disinfectant is unstable, after open bottle cover, concentration with the holding time passage by
Gradually reduce.And sodium hypochlorite is too high, there is sensitization, or even cause chlorine poisoning, when soaking footgear, higher effective chlorine contains
Amount can also cause necessarily to damage to footgear.So the available chlorine content of disinfectant of the present invention is 2 × 105ppm。
As another embodiment of this case, described second dose of plants essential oil is the fourth stage.Fourth stage essential oil it is natural it is pure,
Gentle pro-skin, and price is relatively low.
This case additionally provides a kind of double-formulation tinea pedis composition application method, comprises the following steps:In tub or pottery pot
In be put into 40-50 DEG C of warm water, the water surface was not had instep;
The volume proportion for measuring first dose, described first dose and water is 1-1.25:1000;
First dose measured is poured into tub or pottery pot, is stirred;
Both feet are put into immersion 3-5 minutes in water;
Water in tub or pottery pot is outwelled and rinsed clean while both feet warm water washing is clean;
40-50 DEG C of warm water is put into tub or pottery pot, the water surface was not had instep;
Second dose of 5-7 drops are added dropwise in per 1000mL water, stir;
Pin is put into immersion 20-30 minutes in water.
It is further comprising the steps of as another embodiment of this case, methods described:
40-50 DEG C of warm water is put into tub or pottery pot, the water surface was not had footgear surface;
The volume proportion for measuring first dose, described first dose and water is 1.25-1.5:1000;
Chlorine-containing disinfectant is poured into tub or pottery pot, stirred;
Footgear is put into immersion 15-20 minutes in water.
Clinical data (one)
In 7-9 months, medication treatment is given to 25 young men with vesicle tinea pedis, is matched according to first dose and water
For 1.25:1000 ratio prepares foot-immersing water, immersion both feet 4 minutes, foot-immersing water, leaching is prepared according to the ratio of every 1000mL6 drops
Bubble both feet 25 minutes, it is 1.5 according to first dose and water proportioning:1000 ratio prepares soaking water, immersion footgear 20 minutes, uses
Water temperature is 45 DEG C, and daily medication is once.Table one lists the therapeutic effect for the component that different embodiments have, wherein each embodiment
Corresponding 5 patients, data corresponding to each embodiment are the average value of 5 patient datas, after symptom disappears, stop first dose with
Medicine, it is continuing with second dose and carries out treatment 20 days, soak footgear in fashion described above daily during treatment.
Table one
Clinical data (two)
On July 13rd, 2017, medication treatment is given to 30 young men with vesicle tinea pedis, according to the embodiment of table one
The medicine of tinea pedis is controlled made of the component enumerated in 3, takes identical tub, measures 45 DEG C of warm water respectively, according to first dose with
Water proportioning is 1.5:1000 ratio immersion footgear 20 minutes, table two lists first dose and controlling during second dose of different addition
Therapeutic effect.Wherein corresponding 6 patients of each embodiment, data corresponding to each embodiment are the average value of 6 patient datas, disease
After shape disappears, stop first dose of medication, be continuing with second dose and carry out treatment 20 days, soaked in fashion described above daily during treatment
Footgear.
Table two
Clinical data (three)
On August 5th, 2017, medication treatment is given to the young man with vesicle tinea pedis, is enumerated in the embodiment 3 of table one
The medicine of tinea pedis is controlled made of component, takes identical tub, measures 45 DEG C of warm water 4L respectively, is according to first dose and water proportioning
1.25:1000 ratio is treated, and immersion footwear are listed with immersion footgear, table three with aqueous phase with first dose daily during treatment
During socks first dose with the different ratio of water, recurrence after it is treated.Wherein each corresponding 4 patients of embodiment, it is each to implement
Data are the average value of 4 patient datas corresponding to example, soak footgear in fashion described above daily during treatment.
Table three
Although embodiment of the present invention is disclosed as above, it is not restricted in specification and embodiment listed
With it can be applied to various suitable the field of the invention completely, can be easily for those skilled in the art
Other modification is realized, therefore under the universal limited without departing substantially from claim and equivalency range, it is of the invention and unlimited
In specific details.
Claims (8)
1. a kind of double-formulation controls tinea pedis composition, including first containing chlorine-containing disinfectant dose and second containing plants essential oil
Agent, it is characterised in that described first dose, by weight percentage, including following component:
Chlorine-containing disinfectant 92.5-95.9%;
Potassium permanganate 1.1-1.5%;
Sodium chloride 3-6%;
Described second dose, by weight percentage, including following component:
2. double-formulation according to claim 1 controls tinea pedis composition, it is characterised in that:Described first dose, by weight percentage
Than meter, including following component:
Chlorine-containing disinfectant:93%;
Potassium permanganate:1.2%;
Sodium chloride:5.8%;
Second dose containing plants essential oil, including following component:
3. double-formulation according to claim 1 or 2 controls tinea pedis composition, it is characterised in that:Described chlorine-containing disinfectant is
One kind in sodium hypochlorite, calcium hypochlorite, sodium dichloro cyanurate, sym-closene, Efficacious Disinfeitant or oronain T.
4. double-formulation according to claim 1 or 2 controls tinea pedis composition, it is characterised in that:Described chlorine-containing disinfectant is pure
Spend for food-grade or medical grade.
5. double-formulation tinea pedis composition according to claim 1 or 2, it is characterised in that:In the chlorine-containing disinfectant effectively
Chlorinity is 2 × 105ppm。
6. double-formulation tinea pedis composition according to claim 1 or 2, it is characterised in that:Described second dose of plants essential oil
It is the fourth stage.
7. double-formulation tinea pedis composition application method according to claim 1, it is characterised in that comprise the following steps:
40-50 DEG C of warm water is put into tub or pottery pot, the water surface was not had instep;
The volume proportion for measuring first dose, described first dose and water is 1-1.25:1000;
First dose measured is poured into tub or pottery pot, is stirred;
Both feet are put into immersion 3-5 minutes in water;
Water in tub or pottery pot is outwelled and rinsed clean while both feet warm water washing is clean;
40-50 DEG C of warm water is put into tub or pottery pot, the water surface was not had instep;
Second dose of 5-7 drops are added dropwise in per 1000mL water, stir;
Pin is put into immersion 20-30 minutes in water.
8. double-formulation tinea pedis composition application method according to claim 7, it is characterised in that further comprising the steps of:
40-50 DEG C of warm water is put into tub or pottery pot, the water surface was not had footgear surface;
The volume proportion for measuring first dose, described first dose and water is 1.25-1.5:1000;
Chlorine-containing disinfectant is poured into tub or pottery pot, stirred;
Footgear is put into immersion 15-20 minutes in water.
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2017
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CN1861092A (en) * | 2005-05-12 | 2006-11-15 | 和睿哲 | Application of chlorine-contg. disinfectant in pharmaceutics |
CN1709377A (en) * | 2005-06-02 | 2005-12-21 | 戴荣春 | Foot powder and its preparing method |
DE202013004793U1 (en) * | 2013-05-23 | 2013-08-26 | Ats License Gmbh | Nourishing foot cream for the removal of mushrooms |
CN104138590A (en) * | 2014-06-11 | 2014-11-12 | 龚佳郎 | Traditional Chinese medicinal effervescent tablet with effects of killing dermatophytosis bacteria and fungi and nourishing and preparation method thereof |
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Title |
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刘巧: "《中西医结合皮肤病治疗学》", 31 January 2014, 人民军医出版社 * |
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