CN107823326A - A kind of fish pathogens bacteria inhibitor - Google Patents
A kind of fish pathogens bacteria inhibitor Download PDFInfo
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- CN107823326A CN107823326A CN201711177025.9A CN201711177025A CN107823326A CN 107823326 A CN107823326 A CN 107823326A CN 201711177025 A CN201711177025 A CN 201711177025A CN 107823326 A CN107823326 A CN 107823326A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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Abstract
This programme discloses a kind of fish pathogens bacteria inhibitor of aquaculture technical field, including raw material and its parts by weight be：15~20 parts of 30~50 parts of sweet wormwood, 15~20 parts of tobacco, 1~1.5 part of EM bacterium, 10~15 parts of cordate houttuynia and the bighead atractylodes rhizome.Fish pathogens bacteria inhibitor in this programme is by suppressing or killing pathogen flora, improve beneficial bacterium flora, improve fish pond water environment, improve fish immunity power and the fish that catch an illness are treated or non-proliferation so that profitable strain accounting is significantly improved.
Description
Technical field
The invention belongs to aquaculture technical field, more particularly to a kind of fish pathogens bacteria inhibitor.
Background technology
Fish be body breathed by corneoscute, with the gill, by the swimming of the coordinative role of the swing of afterbody and trunk and fin and
The alternating temperature aquatic vertebrate ingested with upper lower jaw, the Vertebrate belonged in Chordata.
During fish culture, fish are often because of Cytophaga Columnaris, white skin pole hair bacillus, Pseudomonas fluorescens, gas list
The pathogens such as born of the same parents bacterium, Enterozoa cause it the diseases such as hemorrhage, enteritis disease, saprolegniasis, fin rot occur.In order to reduce fish
The generation of class disease, at present mainly using bleaching powder, sodium dichloro cyanurate, sym-closene, disinfection agent of chlorine dioxide etc.
Medicine is killed to pathogenetic bacteria；Which is preferable to the killing action of pathogenetic bacteria and Enterozoa, but its
While killing pathogenetic bacteria and Enterozoa, it can further stimulate fish cuticular breakdown part and fish intestines scorching
Disease, cause fish disease more serious.Meanwhile during being sterilized to fish pond, it is also desirable to veteran poultry feeders root
The dosage of medicine and time are determined according to the growing state of fish in fish pond, easily because addition is excessive or the addition time is too early or mistake
In evening, cause fish dead.
For such case, the patent of Application No. " CN201710430774.1 " provides a kind of fish bactericide, its
Include the component of following parts by weight：Dandelion concentrate 10-15 parts；Dried orange peel 15-20 parts；Salt 3-8 parts；Converted starch 10-15
Part；Food acidity conditioning agent 2-5 parts；Antioxidant 1-4 parts；Protease 20-40 parts.The Fungicidal substance of the bactericide mainly has Pu
Public English concentrate, dried orange peel and salt, and the bactericidal effect of dried orange peel is poor, the content of salt is relatively low, therefore main Fungicidal substance
It is dandelion concentrate, but dandelion concentrate mainly has stronger sterilization to staphylococcus aureus, hemolytic streptococcus etc.
Effect, its bactericidal range is limited, Cytophaga Columnaris, white skin pole hair bacillus, Pseudomonas fluorescens, Aeromonas to fish etc.
Pathogen plays a part of very little, it is difficult to realizes suppression large-scale to fish-pathogenic bacteria and kills.
In addition, either chemical bactericide or traditional Chinese medicine bactericide, it to fish-pathogenic bacteria while killing, together
Sample has carried out largely killing to beneficial bacterium, therefore it is actually only reduction of the ill probability of fish, but has to improving fish pond
Beneficial bacteria flora accounting effect less (general only 4% or so) of beneficial bacteria flora accounting lifting.
The content of the invention
The invention is intended to provide a kind of fish pathogens bacteria inhibitor, to solve traditional Chinese medicine bactericide of the prior art to beneficial
The problem of lifting of bacterium flora accounting is low.
A kind of fish pathogens bacteria inhibitor in this programme, including raw material and its parts by weight be：30~50 parts of sweet wormwood,
15~20 parts of 15~20 parts of tobacco, 1~1.5 part of EM bacterium, 10~15 parts of cordate houttuynia and the bighead atractylodes rhizome.
The beneficial effect of this programme：This programme is from raw material based on sweet wormwood, tobacco and EM bacterium.Sweet wormwood has quick suppression
Malaria plasmodium processed is ripe, suppress and kill shigella dysenteriae, anti-schistosome and Leptospira, the effect of resisiting influenza virus.Meanwhile
Sweet wormwood is to MRSE, micrococcus catarrhalis, bacillus anthracis, corynebacterium diphtheriae, staphylococcus aureus, Pseudomonas aeruginosa, dysentery bar
Bacterium, shigella flexneri, Escherichia coli, micrococcus catarrhalis, the germ such as A type and paratyphoid B stalk bacterium, which has, suppresses or kills work
With.In addition, the qinghaosu in sweet wormwood can also improve lymphocyte transformation rate, promote immunization of cell.Sweet wormwood amber in sweet wormwood
Ester can promote Ts cells to breed, and suppress TE cells and produce, the release of interleukins and various inflammatory mediators is prevented, so as to play
Immunoregulation effect.It is poisonous and tobacco is warm-natured sweet, there is detumescence, removing toxic substances, desinsection and other effects, it is to Cytophaga Columnaris, white
The pathogens such as skin pole hair bacillus, Pseudomonas fluorescens, Aeromonas have certain suppression or kill effect.
And cordate houttuynia acrid flavour, cold, return lung warp can clearing heat and detoxicating, detumescence treatment sore, promoting urination and removing dampness, clearing away heat to cure dysentery, stomach invigorating
Help digestion, there is obvious suppression to make to the streptococcus of hemolytic, staphylococcus aureus, Bacillus influenzae, micrococcus catarrhalis, pneumococcus
With.Also there is effect to Escherichia coli, shigella dysenteriae, typhoid bacillus.The bighead atractylodes rhizome is to acrothesium floccosum, star nocardia, meninx
Scorching coccus, typhoid bacillus, paratyphoid bacillus A, shigella flexneri, Escherichia coli, Pseudomonas aeruginosa etc. have different degrees of
Bacteriostasis, while also have the function that to promote hematopoiesis function, strengthening the spleen and stomach and improve resistance against diseases.
Sweet wormwood is aided with cordate houttuynia and the bighead atractylodes rhizome with tobacco, on the one hand continues to expand the antibacterial model of fish pathogens bacteria inhibitor
Enclose, while sweet wormwood, cordate houttuynia and the bighead atractylodes rhizome are by lifting the immunity of fish, promoting taste health, enhancing hematopoiesis function, Jin Erzeng
The strong system of fish, reduces its ill probability.The antipyretic and antidote functions of other sweet wormwood, cordate houttuynia and the bighead atractylodes rhizome, reduce cigarette
Murder by poisoning of the grass to fish, while treatment or non-proliferation are played a part of to the fish of illness.
The suppression or insect killing effect of sweet wormwood, tobacco cordate houttuynia and the bighead atractylodes rhizome to pathogen are imitated much stronger than the suppression to beneficial bacterium
Fruit, but also have certain inhibitory action to beneficial bacterium.EM bacterium are added with the fish pathogens bacteria inhibitor of this programme, EM bacterium are one
Kind includes the Mixed Microbes of the beneficial bacteriums such as photosynthetic bacteria, saccharomycete, lactic acid bacteria.The EM bacterium one side rapid expansions content of beneficial bacterium,
It is in absolute predominance colony relative to pathogen, further suppress the growth of pathogen.On the other hand, it is photosynthetic in EM bacterium
Bacterium can separate the hydrogen in the sulphur hydrogen and hydrocarbon in fish pond, and change harmful substance is innocuous substance, and with fish pond
In organic matter, pernicious gas (hydrogen sulfide etc.) and carbon dioxide, nitrogen etc. be matrix, synthesis carbohydrate, amino acids, vitamin
Class, nitrogen compound, antiviral substance and physiological activator etc..The gases such as carbon dioxide in fish pond, hydrogen sulfide are reduced to contain
Amount, is advantageous to purifying water body, while provides necessary condition for fish pond dissolved oxygen, is advantageous to improve the oxygen dissolving in fish pond
Amount.
Fish pathogens bacteria inhibitor in this programme is by suppressing or killing pathogen flora, raising beneficial bacterium flora, change
Kind fish pond water environment, improve fish immunity power and the fish that catch an illness are treated or non-proliferation so that profitable strain accounting is lifted
16~28%.
Further, the fish pathogens bacteria inhibitor, including raw material and its parts by weight be：35~45 parts of sweet wormwood, cigarette
15~20 parts of 15~20 parts of grass, 1~1.5 part of EM bacterium, 10~12 parts of cordate houttuynia and the bighead atractylodes rhizome.
Further, the fish pathogens bacteria inhibitor, including raw material and its parts by weight be：40~50 parts of sweet wormwood, cigarette
15~18 parts of 15~20 parts of grass, 1~1.5 part of EM bacterium, 10~15 parts of cordate houttuynia and the bighead atractylodes rhizome.
Further, the fish pathogens bacteria inhibitor, including raw material and its parts by weight be：45 parts of sweet wormwood, tobacco 18
20 parts of part, 1.5 parts of EM bacterium, 12 parts of cordate houttuynia and the bighead atractylodes rhizome.
Further, the fish pathogens bacteria inhibitor also includes the radix glycyrrhizae that parts by weight are 10~20 parts.Radix glycyrrhizae has clear
Thermal detoxification, treat for stomachache, suffer from abdominal pain, gastrocnemius contraction urgency pain, it is antiacid, alleviate the effect such as gastrointestinal smooth muscle spasmus, anti-inflammatory and antiallergy,
It is combined with sweet wormwood, cordate houttuynia and the bighead atractylodes rhizome, be advantageous to play a protective role to the stomach of fish, and to fish because of pathogen
And the disease infected plays therapeutic action.
Further, the fish pathogens bacteria inhibitor also includes the subprostrate sophora that parts by weight are 10~15 parts.Subprostrate sophora master
All medicines poison is solved, relieves pain, the pyogenic infections from tumour or sore that disappears, acute febrile fever and cough and kill small worm；It kills effect to parasite with certain, together
When, it is to fish because heavy metal or pathogenic bacterial infection have certain preventive and therapeutic effect.
Embodiment
Below by the further details of explanation of embodiment：
Embodiment：A kind of fish pathogens bacteria inhibitor, including raw material and its parts by weight it is as shown in table 1：
Table 1
The fish pathogens bacteria inhibitor of embodiment 1~8, in addition to raw material and its parts by weight have differences, production method
Equally, by taking embodiment 1 as an example, its preparation method is：Method 1, sweet wormwood, tobacco, cordate houttuynia, the bighead atractylodes rhizome, radix glycyrrhizae and the mountain beans that will be done
Powder is made in root, is then mixed to get fish pathogens bacteria inhibitor with EM bacterium.Method 2, by weight to sweet wormwood, tobacco, cordate houttuynia,
The bighead atractylodes rhizome, radix glycyrrhizae and subprostrate sophora carry out vegetation water extraction, and the vegetation water of extraction and EM bacterium then are mixed to get into fish-pathogenic bacteria suppression
Preparation.
The application method of fish pathogens bacteria inhibitor, launch the once fish as made from method 1 to fish pond within every 10~15 days
Cause of disease bacteria inhibitor, each injected volume of fish pathogens bacteria inhibitor is 15kg/ mus.
Comparative example 1：Bacteriostatic agent is used as using bleaching powder.
Comparative example 2:Bacteriostatic agent is used as using the fish bactericide in Application No. " CN201710430774.1 ".
Experimental comparison：Experimental group is divided into 10 groups, respectively embodiment 1~8 and comparative example 1~2；Embodiment 1~8 and right
Ratio 1~2 (the application method use that respective bacteriostatic agent provides is pressed in the use of bacteriostatic agent) in addition to bacteriostatic agent is different, other cultivation
Mode is the same.Each experimental group fry quantity is 100, and the size of fry, growth conditions are similar, fry body weight 0.5kg or so,
Nursing time 4 months；Count fry death toll, and the hemorrhage of live fish, enteritis disease, saprolegniasis, fin rot situation, beneficial bacterium
Flora accounting enhancing rate, specific data are as shown in table 2：
As shown in Table 2, for embodiment 1~8 relative to comparative example 1~2, the accounting lifting of beneficial bacterium is higher, 17% with
On, while there is not the dead phenomenon of fry in it, and rate of falling ill is also relative that comparative example 1~2 is much lower, itself main reason is that
The fish pathogens bacteria inhibitor that embodiment 1~8 uses is by suppressing or killing pathogen flora, improve beneficial bacterium flora, improvement
Fish pond water environment, improve fish immunity power and the fish that catch an illness treated or non-proliferation etc. is many-sided that the shoal of fish is nursed,
And then serve more preferable effect.And although comparative example 1 has preferable killing effect to pathogen, its chemical substance is to fish
Group has stimulation, can particularly deteriorate the state of an illness for fry of falling ill, and then cause fry death more.And comparative example 2 uses
Although stimulation of the bactericide to the shoal of fish it is small, its bactericidal effect is bad, causes the rate of falling ill of the shoal of fish still higher.
Above-described is only embodiments of the invention, and the general knowledge such as known concrete structure and characteristic is not made herein in scheme
Excessive description., without departing from the structure of the invention, can be with it should be pointed out that for those skilled in the art
Several modifications and improvements are made, these should also be considered as protection scope of the present invention, and these are implemented all without the influence present invention
Effect and practical applicability.The scope of protection required by this application should be based on the content of the claims, in specification
The records such as embodiment can be used for the content for explaining claim.
Claims (6)
- A kind of 1. fish pathogens bacteria inhibitor, it is characterised in that：Including raw material and its parts by weight be：30~50 parts of sweet wormwood, 15~20 parts of 15~20 parts of tobacco, 1~1.5 part of EM bacterium, 10~15 parts of cordate houttuynia and the bighead atractylodes rhizome.
- 2. fish pathogens bacteria inhibitor according to claim 1, it is characterised in that：Including raw material and its parts by weight For：15~20 parts of 35~45 parts of sweet wormwood, 15~20 parts of tobacco, 1~1.5 part of EM bacterium, 10~12 parts of cordate houttuynia and the bighead atractylodes rhizome.
- 3. fish pathogens bacteria inhibitor according to claim 1, it is characterised in that：Including raw material and its parts by weight For：15~18 parts of 40~50 parts of sweet wormwood, 15~20 parts of tobacco, 1~1.5 part of EM bacterium, 10~15 parts of cordate houttuynia and the bighead atractylodes rhizome.
- 4. the fish pathogens bacteria inhibitor according to any one of claims 1 to 3, it is characterised in that：Including raw material and its Parts by weight are：20 parts of 45 parts of sweet wormwood, 18 parts of tobacco, 1.5 parts of EM bacterium, 12 parts of cordate houttuynia and the bighead atractylodes rhizome.
- 5. fish pathogens bacteria inhibitor according to claim 4, it is characterised in that：It is 10~20 parts also to include parts by weight Radix glycyrrhizae.
- 6. fish pathogens bacteria inhibitor according to claim 5, it is characterised in that：It is 10~15 parts also to include parts by weight Subprostrate sophora.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711177025.9A CN107823326A (en) | 2017-11-22 | 2017-11-22 | A kind of fish pathogens bacteria inhibitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711177025.9A CN107823326A (en) | 2017-11-22 | 2017-11-22 | A kind of fish pathogens bacteria inhibitor |
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| Publication Number | Publication Date |
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| CN107823326A true CN107823326A (en) | 2018-03-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201711177025.9A Pending CN107823326A (en) | 2017-11-22 | 2017-11-22 | A kind of fish pathogens bacteria inhibitor |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721594A (en) * | 2018-06-22 | 2018-11-02 | 贵州龙源冷水渔业有限公司 | A kind of sturgeon germ inhibitor and preparation method thereof |
| CN108815224A (en) * | 2018-06-22 | 2018-11-16 | 贵州龙源冷水渔业有限公司 | A kind of sturgeon germ inhibitor |
| CN109170202A (en) * | 2018-09-12 | 2019-01-11 | 盐城工学院 | A kind of preparation method and applications of Chinese herbal feed additive that preventing and treating mullet saprolegniasis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213866A (en) * | 2015-11-10 | 2016-01-06 | 镇江荣邦生物科技有限公司 | A kind of Chinese medicine microorganism compound preparation preventing and treating fish bacterial disease |
| CN106852396A (en) * | 2015-12-08 | 2017-06-16 | 上海泓宝绿色水产股份有限公司 | A kind of aquatic livestock liver-care preparations and its preparation and application |
-
2017
- 2017-11-22 CN CN201711177025.9A patent/CN107823326A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213866A (en) * | 2015-11-10 | 2016-01-06 | 镇江荣邦生物科技有限公司 | A kind of Chinese medicine microorganism compound preparation preventing and treating fish bacterial disease |
| CN106852396A (en) * | 2015-12-08 | 2017-06-16 | 上海泓宝绿色水产股份有限公司 | A kind of aquatic livestock liver-care preparations and its preparation and application |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721594A (en) * | 2018-06-22 | 2018-11-02 | 贵州龙源冷水渔业有限公司 | A kind of sturgeon germ inhibitor and preparation method thereof |
| CN108815224A (en) * | 2018-06-22 | 2018-11-16 | 贵州龙源冷水渔业有限公司 | A kind of sturgeon germ inhibitor |
| CN109170202A (en) * | 2018-09-12 | 2019-01-11 | 盐城工学院 | A kind of preparation method and applications of Chinese herbal feed additive that preventing and treating mullet saprolegniasis |
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