CN107643393B - Sample analyzer, method for cleaning sample analyzer, and use of liquid containing hemolytic agent component - Google Patents
Sample analyzer, method for cleaning sample analyzer, and use of liquid containing hemolytic agent component Download PDFInfo
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- CN107643393B CN107643393B CN201610584023.0A CN201610584023A CN107643393B CN 107643393 B CN107643393 B CN 107643393B CN 201610584023 A CN201610584023 A CN 201610584023A CN 107643393 B CN107643393 B CN 107643393B
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Abstract
The invention relates to a sample analyzer, a cleaning method thereof and application of a liquid containing hemolytic agent components. The sample analyzer is used for analyzing a sample to be analyzed, and comprises: a latex immunoassay device; a sample supply device that supplies a sample to be analyzed to the latex immunoassay device; a first reagent supplying device which supplies a latex immunoreaction reagent to the latex immunoassay device to perform a latex immunoreaction with the sample to be analyzed, so as to facilitate the latex immunoassay of the latex immunoassay device; the sample analyzer includes a second reagent supply device that supplies a liquid containing a hemolytic agent component to the latex immunoassay device to wash a reaction residue of the latex immunoassay device. The invention can simplify the cleaning procedure of the sample analyzer and reduce the cost.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a sample analyzer, a cleaning method thereof and application of liquid containing hemolytic agent components in cleaning residues generated in an immunoassay process.
Background
Sample analyzers are common medical instruments in the medical field for analyzing samples such as blood. The sample analyzer may comprise one or more analytical devices for e.g. latex immunoassays, blood routine assays, etc. In the latex immunoassay, a latex immunoreaction reagent and a sample to be analyzed are used for latex immunoreaction, so that the latex immunoassay is completed.
To facilitate maintenance and reuse of the assay device, the latex immunoassay device typically needs to be cleaned after the latex immunoassay is completed. In the prior art, a latex immunoassay device generally needs to be cleaned by using a special cleaning solution, so that the process is complicated and the cost is high.
Disclosure of Invention
Accordingly, there is a need for a sample analyzer that is relatively simple in cleaning process and low in cost. The sample analyzer of the present invention is used for analyzing a sample to be measured, and includes:
a latex immunoassay device;
a sample supply device that supplies a sample to be analyzed to the latex immunoassay device;
a first reagent supplying device which supplies a latex immunoreaction reagent to the latex immunoassay device to perform a latex immunoreaction with the sample to be analyzed, so as to facilitate the latex immunoassay of the latex immunoassay device; the sample analyzer includes a second reagent supply device that supplies a liquid containing a hemolytic agent component to the latex immunoassay device to wash a reaction residue of the latex immunoassay device.
In one embodiment, the sample analyzer may further comprise: and a controller connected to the latex immunoassay device and the second reagent supply device, the controller receiving a signal of completion of the latex immunoassay from the latex immunoassay device and controlling the second reagent supply device to supply a liquid containing a hemolytic agent component to the latex immunoassay device.
In one embodiment, the sample analyzer may further comprise:
a blood routine analysis device that performs blood routine analysis on a sample to be analyzed;
the sample supply device provides a sample to be analyzed to the blood routine analysis device;
the second reagent supply device comprises a hemolytic agent supply mechanism which supplies hemolytic agent required by blood routine analysis to the blood routine analysis device; the hemolytic agent supply mechanism further supplies the hemolytic agent to the latex immunoassay device to wash the reaction residue in the latex immunoassay device.
In one embodiment, the sample analyzer may further comprise:
a blood routine analysis device that performs a blood routine analysis on the sample;
the sample supply device provides a sample to be analyzed to the blood routine analysis device;
the second reagent supply device comprises a hemolytic agent supply mechanism and a test solution supply mechanism, wherein the hemolytic agent supply mechanism supplies hemolytic agent required by blood routine analysis to the blood routine analysis device, and the hemolytic agent and the sample to be analyzed form a test solution after the blood routine analysis; the sample solution supply mechanism acquires the sample solution from the blood routine analysis device and supplies the sample solution to the latex immunoassay device to wash the reaction residue in the latex immunoassay device.
In one embodiment, the latex immunoassay may comprise: c-reactive protein analysis.
In one embodiment, the hemolytic agent may contain a quaternary ammonium salt cationic surfactant.
In another aspect, the present invention also provides a method of cleaning a sample analyzer, comprising:
after completion of the latex immunoassay, a liquid containing a hemolytic agent component is supplied to a latex immunoassay device of a sample analyzer to wash a reaction residue of the latex immunoassay device.
In one embodiment, the method for washing a sample analyzer, the liquid containing a hemolytic agent component may be provided from a hemolytic agent supply mechanism for supplying hemolytic agent to a blood routine analysis device; alternatively, the liquid containing the hemolytic agent component may be supplied from a sample liquid supply mechanism that obtains a sample liquid after blood routine analysis by the blood routine analysis apparatus.
In one embodiment, the method for cleaning a sample analyzer may include: the controller sends a cleaning signal after the latex immunoassay is completed, and the hemolytic agent supply mechanism obtains hemolytic agent after receiving the cleaning signal and supplies the hemolytic agent to the latex immunoassay device to clean reaction residues of the latex immunoassay device; or
The controller sends a cleaning signal after the latex immunoassay is completed and sends a liquid taking signal after the blood routine analysis, and the test liquid supply mechanism obtains test liquid after the blood routine analysis to the latex immunoassay device to clean reaction residues of the latex immunoassay device after receiving the cleaning signal and the liquid taking signal.
In a further aspect, the present invention also provides the use of a liquid comprising a haemolysing agent component for washing reaction residues generated during an immunoassay.
In one embodiment, the liquid containing the hemolytic agent component may include one or more of hemolytic agent and test solution after the blood routine analysis.
Compared with the prior art, the method directly uses the liquid containing the hemolytic agent component to clean the reaction residue of the latex immunoassay device, and the hemolytic agent can contain quaternary ammonium salt cationic surfactant to dissolve red blood cells. The applicant has found through research that the hemolytic agent for routine blood analysis can be used for cleaning the latex immunoassay device and can clean the reaction residue. Because the liquid containing the hemolytic agent component is common liquid in sample analysis, a special cleaning solution does not need to be specially prepared, so that the working procedure is simplified, and the cost is saved.
Drawings
Fig. 1 is a block diagram of a sample analyzer according to an embodiment of the present invention.
Fig. 2 is a block diagram of a sample analyzer according to another embodiment of the present invention.
Fig. 3 is a block diagram of a sample analyzer according to yet another embodiment of the present invention.
Fig. 4 is a block diagram of a sample analyzer according to still another embodiment of the present invention.
Fig. 5 is a detailed structural diagram of a sample analyzer according to an embodiment of the present invention.
Fig. 6 is a detailed structural view of a sample analyzer according to another embodiment of the present invention.
FIG. 7 is a flow chart of a method for cleaning a sample analyzer in accordance with one embodiment of the present invention.
Fig. 8 is a flow chart of a sample analyzer cleaning method according to another embodiment of the present invention.
Fig. 9 is a flow chart of a sample analyzer cleaning method according to yet another embodiment of the present invention.
Description of the main elements
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The following detailed description will further illustrate the invention in conjunction with the above-described figures.
Detailed Description
The sample analyzer provided by the invention is used for analyzing a sample to be tested, and the sample to be tested can be a blood sample of a tested person. Referring to fig. 1, the sample analyzer basically includes:
a latex immunoassay device 11 for performing a latex immunoassay on the sample;
a sample supply device 12 for supplying a sample to be analyzed to the latex immunoassay device;
a first reagent supplying device 13 for supplying a latex immunoreaction reagent to the latex immunoassay device 11; performing latex immunoreaction on the latex immunoreaction reagent and a sample to be analyzed, and then performing latex immunoassay by using a latex immunoassay device 11;
and a second reagent supplying device 14 for supplying a liquid containing a hemolytic agent component to the latex immunoassay device 11 to wash a reaction residue of the latex immunoassay in the latex immunoassay device 11.
Each of the above-described apparatuses may be provided with its own controller to control the supply, analysis, and other operations of each apparatus. In another embodiment, a controller 15 may be provided separately from the above-described devices, as shown in fig. 2. The controller 15 is connected to the latex immunoassay device 11, the sample supply device 12, the first reagent supply device 13, and the second reagent supply device 14, respectively, and controls the supply, analysis, and other operations of these devices.
In the embodiment of the present invention, the liquid containing the hemolytic agent component may be obtained from a reagent required for other analysis besides the latex immunoassay, or a waste liquid after other analysis is performed, i.e., a test solution. The arrangement can omit the use of a special cleaning solution of the latex immunoassay device, thereby facilitating the reagent management, saving the process and saving the cost.
An example of other analysis is blood routine analysis. Accordingly, as shown in fig. 3, a sample analyzer according to an embodiment of the present invention may include: a blood routine analyzing device 16 for performing blood routine analysis, such as red blood cell count, platelet count, white blood cell count and classification, on the sample to be analyzed.
As shown in fig. 3, the blood routine analyzing device 16 is connected to the controller 15, and may be controlled by the controller 15. It is obvious that, as in the example of fig. 1, the blood routine analysis device 16 may also be provided with a controller on its own, without having to have a separate controller 15.
Similar to latex immunoassay, the blood routine analysis is performed by using a sample to be analyzed and a reagent for blood routine analysis in a blood routine analysis device. Wherein the reagent for routine blood analysis comprises a hemolytic agent. Accordingly, as shown in fig. 3, the second reagent supplying device 14 may include a hemolytic agent supplying mechanism 14a for supplying a hemolytic agent required for routine blood analysis to the blood routine analyzing device 16. On the other hand, the sample supply device 12 is also coupled to the blood routine analyzing device 16, and is also used for supplying the sample to be measured to the blood routine analyzing device 16.
The liquid containing the hemolytic agent component for washing the latex immunoassay device 11 may be obtained from a hemolytic agent required for routine blood analysis, or may be obtained from a test solution obtained by reacting the hemolytic agent with a sample to be tested. If the reaction residue in the latex immunoassay device is washed with the hemolytic agent as it is, the hemolytic agent supply mechanism 14a may be shared with reference to FIG. 3. That is, the hemolytic agent supply mechanism 14a supplies the hemolytic agent to the blood routine analysis device 16 on the one hand to perform the blood routine analysis with the sample in the blood routine analysis device 16, thereby performing the blood routine analysis on the sample. On the other hand, the hemolytic agent supply mechanism 14a also supplies the hemolytic agent to the latex immunoassay device 11 to wash the latex immunoassay device 11 of the latex immunoassay residues after the latex immunoassay is performed.
If the liquid containing the hemolytic agent component is a sample solution obtained by reacting the hemolytic agent with the sample to be tested, the second reagent supply device 14 includes two mechanisms, i.e., a hemolytic agent supply mechanism 14a and a sample solution supply mechanism 14b, as shown in fig. 4. Wherein the hemolytic agent supply mechanism 14a is the same as that in FIG. 3 and will not be described in detail. The sample supply mechanism 14b is coupled to the blood routine analyzer 16, and after the blood routine analysis, the sample supply mechanism 14b takes a sample solution formed after the blood routine analysis from the blood routine analyzer 16 and supplies the sample solution formed after the blood routine analysis to the latex immunoassay analyzer 11 to wash the reaction residue in the latex immunoassay analyzer 11.
The hemolytic agent may contain a quaternary ammonium salt cationic surfactant to lyse erythrocytes. The applicant finds through research that the hemolytic agent for routine blood analysis can be used for cleaning the latex immunoassay device 11, can clean reaction residues, and has the cleaning effect that no obviously visible milky white colloidal substances are left on the inner surfaces of the pipeline and the reaction cell of the cleaned latex immunoassay device 11, and the possible residual quantity of the reaction residues does not influence the accuracy of the next latex immunoassay.
In one embodiment, the latex immunoassay comprises: c-reactive protein (CRP) assay. It is understood that the latex immunoassay may be any other assay for the measurement of an analyte by a latex immunoassay.
As shown in fig. 5, the latex immunoassay device 11 includes a latex immunoreaction tank 111, where latex immunoreaction occurs between a sample to be tested and a reagent for latex immunoassay, and the latex immunoreaction tank 111 needs to be continuously reused, so that the latex immunoreaction tank 111 needs to be cleaned after each latex immunoreaction and analysis.
The sample supply device 12 may include a sample storage mechanism 121, a liquid conduit 122, and a control valve 123. The sample is stored in the sample storage mechanism 121 before the analysis is started, the liquid communication pipeline 122 is connected with the latex immunoreaction pool 111, the opening and closing of the control valve 123 can control the connection or the closing of the liquid communication pipeline 122, the control valve 123 is controlled by the controller 15, when the controller 15 sends out an opening signal, the control valve 123 is opened, so that the liquid communication pipeline 122 is connected, and the sample stored in the sample storage mechanism 121 can be input into the latex immunoreaction pool 111 through the liquid communication pipeline 122; when the controller 15 sends a closing signal, the control valve 123 is closed, so that the liquid passage 122 is closed, and the sample stored in the sample storage mechanism 121 is not input to the latex immunoreaction tank 111. It will be appreciated by those skilled in the art that the fluid line may be replaced by a sampling needle.
Similarly, the first reagent supply device 13 may include a first reagent storage mechanism 131, a liquid passage 132, and a control valve 133. The first reagent, i.e., the reagent for latex immunoassay, is stored in the first reagent storage means 131 before the start of analysis. The operation mechanism of the liquid passing line 132 and the control valve 133 is similar to that of the liquid passing line 122 and the control valve 123, that is, the first reagent can be supplied to the latex immunoreaction pool 111 or stopped from being supplied under the control of the opening signal or the closing signal of the controller 15.
Similarly, the second reagent supplying device 14 may include a second reagent storage mechanism 141, a first liquid passage 142, and a first control valve 143. The second reagent, i.e., the blood lysing agent, is stored in the second reagent storage mechanism 141 before the analysis is started. The working mechanism of the first liquid passing line 142 and the first control valve 143 is similar to that of the liquid passing line 122 and the control valve 123, that is, the hemolytic agent can be supplied to the latex immunoreaction tank 111 or can be stopped under the control of the opening signal or the closing signal of the controller 15.
In one embodiment, the controller 15 sends a cleaning signal after the latex immunoassay is completed, and the control valve 143 is opened when the signal is sent, i.e., the cleaning signal indicates that the latex immunoreaction cell 111 is waiting for cleaning. Since the control valve 143 is opened, the liquid communication line 142 from the second reagent storage mechanism 141 to the latex immunoreaction pool 111 is conducted, and the hemolytic agent can reach the latex immunoreaction pool 111 to clean the reaction residue in the latex immunoreaction pool 111.
Referring to fig. 5, the blood routine analyzing apparatus 16 further includes a blood routine reaction cell 161, where the sample to be tested reacts with the hemolytic agent to obtain a test solution, and the test solution is provided to the detector to complete the blood routine analysis. Wherein each analysis may have a respective reaction cell in which a respective kind of routine analysis of the blood is performed. Accordingly, there may be a plurality of hemolytic agents of corresponding types for use in the various blood routine analyses described above, respectively. In addition, a sample to be tested, such as a human blood sample, is usually diluted with a diluent and then mixed to be used as a sample to be tested.
The second reagent supply 14 may further include a second vent line 144, a second control valve 145. The second control valve 145 may open or close the second vent line 144 to supply the hemolytic agent to the blood routine reaction tank 161 or stop the supply under the control of the controller 15.
In another embodiment, the blood routine analysis device 16 further comprises a vent line 162, a control valve 163. The controller 15 sends a cleaning signal after the latex immunoassay is completed and a liquid taking signal after the blood routine analysis is completed, and the control valve 163 is opened only when both signals are sent, i.e., the cleaning signal indicates that the latex immunoreaction pool 111 is waiting for cleaning, and the liquid taking signal indicates that the blood routine reaction pool 161 has produced a test liquid after the blood routine analysis, which can be used for cleaning. Since the control valve 163 is opened, the liquid communication line 162 from the blood standard reaction cell 161 to the latex immunoreaction cell 111 is connected, and the sample solution after the blood standard analysis can reach the latex immunoreaction cell 111 to clean the reaction residue in the latex immunoreaction cell 111.
Referring to fig. 6, the specimen-supply device 12 may include a specimen storage mechanism 121, and the specimen is stored in the specimen storage mechanism 121 before the analysis is started. And the sample analyzer may include a liquid taking mechanism 17, the liquid taking mechanism 17 may include, for example, a sampling needle 171 and a sample sucking syringe 172, and the sampling needle 171 has a storage space for storing a sample, a reagent, or a sample liquid. The draw syringe 172, which may be a powered device for the sampling needle 171, provides the power for the sampling needle to collect or dispense a sample, reagent, or test solution.
The liquid taking mechanism 17 is connected to the controller 15 and controlled by the controller 15, and when the controller 15 sends a liquid taking signal, the liquid taking mechanism 17 moves to the sample storage mechanism 121, the sample suction syringe 172 provides collection power to collect a sample from the sample storage mechanism 121, and the sample is stored in the storage space of the sampling needle 171. When the controller 15 sends a liquid separation signal, the liquid taking mechanism 17 moves to the latex immunoreaction pool 111, the sample suction syringe 172 provides a distribution power, and the sample stored in the storage space of the sampling needle 171 is distributed to the latex immunoreaction pool 111.
It is understood that the first reagent supplying device 13 and the second reagent supplying device 14 may be the same as the sample supplying device 12, only the storage mechanisms, i.e., the first reagent storage mechanism 131 and the second reagent storage mechanism 141 shown in fig. 6 are provided, and the liquid passage line and the control valve connected to the latex immunoreaction bath 111 are omitted. As shown in fig. 6, the sample supply device 12, the first reagent supply device 13, and the second reagent supply device 14 may share the liquid taking mechanism 17, and the liquid taking mechanism 17 may move to the sample storage mechanism 121, the first reagent storage mechanism 131, and the second reagent storage mechanism 141, respectively, under the control of the controller 15, to collect the sample, the first reagent, and the second reagent, and then move to the latex immunoreaction bath 111 in time to distribute the sample, the first reagent, and the second reagent. Similarly, this configuration is also suitable for coupling to a blood cuvette 161. It will also be appreciated that the collection and dispensing of the first or second reagent may be performed using mechanisms similar to the pipetting mechanism 17, respectively, i.e., the sample storage mechanism 121, the first reagent storage mechanism 131 and the second reagent storage mechanism 141 may all have respective independent mechanisms similar to the pipetting mechanism 17.
It is understood that more than one draw syringe 172 may be used. The sample supply device 12, the first reagent supply device 13, and the second reagent supply device 14 can use their own pipette syringes 172 to power the sampling needle 171, and share the sampling needle 171. For example: the sampling needle 171 is moved to the sample storage mechanism 121, the first reagent storage mechanism 131, and the second reagent storage mechanism 141, respectively, under the control of the controller 15, and the sample, the first reagent, and the second reagent are collected by supplying a collection power to the sampling needle 171 through the own pipette syringes 172 of the sample storage mechanism 121, the first reagent storage mechanism 131, and the second reagent storage mechanism 141. The sampling needle 171 is then moved to the latex immunoreaction pool 111 in time, and the sample, the first reagent and the second reagent are dispensed by the sample dispensing syringe 172 of the latex immunoreaction pool 111 providing the dispensing power to the sampling needle 171. Similarly, this configuration is also suitable for coupling to a blood cuvette 161.
It will be appreciated that the above described embodiments are merely illustrative and that features of the various embodiments may be interchanged or combined with each other. For example, the sample supply device 12, the first reagent supply device 13, and the second reagent supply device 14 may each be configured by the liquid passage line and the control valve shown in fig. 5, may each be configured by the liquid taking mechanism shown in fig. 6, may be configured by one or two of the three, and may be configured by the liquid taking mechanism. Similarly, the alternative use of these two configurations is also applicable to coupling with a blood cuvette 161.
The invention also provides a cleaning method of the sample analyzer.
Referring to fig. 7, in step S101, the progress of the latex immunoreaction is detected, in step S102, it is determined whether the latex immunoreaction is completed, if not, the process returns to step S101, if yes, the process proceeds to step S103, a liquid containing a hemolytic agent component is supplied to the latex immunoassay device to wash it, and the whole washing process is finished.
In the present embodiment, in step S103, the liquid containing the hemolytic agent component supplied to the latex immunoassay device is supplied from a hemolytic agent supply mechanism for supplying the hemolytic agent to a blood routine analysis device, or is supplied from a sample liquid supply mechanism that obtains a sample liquid after a blood routine analysis of the blood routine analysis device.
In still another embodiment, referring to fig. 8, in step S201, the progress of the latex immunoreaction is detected, in step S202, it is determined whether the latex immunoreaction is completed, if not, the process returns to step S201, if yes, the process proceeds to step S203, and the controller sends a cleaning signal to the hemolytic agent supplying mechanism; step S204, the hemolytic agent supply mechanism receives the signal and obtains hemolytic agent; then, step S205 is performed, and the hemolytic agent supply mechanism supplies hemolytic agent to the latex immunoassay device to wash the device, and the whole washing process is completed.
In another embodiment, referring to fig. 9, in step S301, the progress of a latex immune reaction is detected; in step S302, judging whether the latex immunoreaction is finished, if not, returning to step S301, and if so, performing step S303, and sending a cleaning signal to the reagent supply mechanism by the controller; in S304, it is determined whether the blood routine analysis is completed, and if not, the process returns to S101, and if so, the process proceeds to S305, and the controller sends a liquid sampling signal to the reagent supply mechanism; in step S306, after receiving the cleaning signal and the liquid extracting signal, the reagent supply mechanism obtains a test solution; then, in step S307, the reagent supply means supplies the sample solution to the latex immunoassay device to wash the device, and the whole washing process is completed.
The present invention also provides the use of a liquid containing a hemolytic agent component for washing reaction residues generated during an immunoassay process.
In one embodiment, the liquid containing the hemolytic agent component includes one or more of hemolytic agent and test solution after routine blood analysis.
The method of the present invention for washing the reaction residue generated during the immunoassay process using the liquid containing the hemolytic agent component is the same as the washing method of the aforementioned sample analyzer, and is not repeated with reference to fig. 7 to 9.
The liquid containing the hemolytic agent component provided by the invention can dissolve red blood cells because the hemolytic agent contains the quaternary ammonium salt cationic surfactant. The applicant has found through research that a hemolytic agent for routine blood analysis can be used for washing reaction residues generated in an immunoassay process. The cleaning effect of the latex immunoassay device can ensure that no obvious milky white colloidal substance is left on the inner surfaces of the pipeline and the reaction tank of the cleaned latex immunoassay device, and the possible residual amount of the reaction residue of the latex immunoassay device can not influence the accuracy of next latex immunoassay.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and the above embodiments are only used for explaining the claims. The scope of the invention is not limited by the description. Any changes or substitutions that can be easily made by those skilled in the art within the technical scope of the present disclosure are included in the scope of the present invention.
Claims (10)
1. A sample analyzer for analyzing a sample to be analyzed, comprising:
a latex immunoassay device;
a sample supply device that supplies a sample to be analyzed to the latex immunoassay device;
a first reagent supplying device which supplies a latex immunoreaction reagent to the latex immunoassay device to perform a latex immunoreaction with the sample to be analyzed, so as to facilitate the latex immunoassay of the latex immunoassay device;
the method is characterized in that: the sample analyzer includes a second reagent supply device that supplies a liquid containing a hemolytic agent component to the latex immunoassay device to wash a reaction residue of the latex immunoassay device;
the liquid containing the hemolytic agent component is taken from a reagent required for analysis other than latex immunoreaction; or
The liquid containing the hemolytic agent component is taken from a test solution after analysis other than latex immunoreaction.
2. The sample analyzer of claim 1, further comprising:
and a controller connected to the latex immunoassay device and the second reagent supply device, the controller receiving a signal of completion of the latex immunoassay from the latex immunoassay device and controlling the second reagent supply device to supply a liquid containing a hemolytic agent component to the latex immunoassay device.
3. The sample analyzer of claim 1, further comprising:
a blood routine analysis device which performs a blood routine analysis on the sample to be analyzed;
the sample supply device provides a sample to be analyzed to the blood routine analysis device;
the second reagent supply device comprises a hemolytic agent supply mechanism which supplies hemolytic agent required by blood routine analysis to the blood routine analysis device; the hemolytic agent supply mechanism also supplies the hemolytic agent to the latex immunoassay device to wash a reaction residue in the latex immunoassay device.
4. The sample analyzer of claim 1, further comprising:
a blood routine analysis device which performs a blood routine analysis on the sample to be analyzed;
the second reagent supply device comprises a hemolytic agent supply mechanism and a test solution supply mechanism, wherein the hemolytic agent supply mechanism supplies hemolytic agent required by blood routine analysis to the blood routine analysis device, the hemolytic agent and the sample to be analyzed form a test solution after the blood routine analysis, and the test solution supply mechanism obtains the test solution from the blood routine analysis device and supplies the test solution to the latex immunoassay device so as to clean reaction residues in the latex immunoassay device.
5. The sample analyzer of claim 1, wherein the latex immunoassay comprises a C-reactive protein assay.
6. The sample analyzer of claim 1, wherein the hemolysing agent comprises a quaternary ammonium salt cationic surfactant.
7. A method of cleaning a sample analyzer, comprising:
after the latex immunoassay is completed, supplying a liquid containing a hemolytic agent component to a latex immunoassay device of a sample analyzer to wash a reaction residue of the latex immunoassay device;
the liquid containing the hemolytic agent component is taken from a reagent required for analysis other than latex immunoreaction; or
The liquid containing the hemolytic agent component is taken from a test solution after analysis other than latex immunoreaction.
8. The method of cleaning a sample analyzer of claim 7,
the liquid containing the hemolytic agent component comes from a hemolytic agent supply mechanism for supplying hemolytic agent to a blood routine analysis device; or
The liquid containing the hemolytic agent component is supplied from a sample liquid supply mechanism that obtains a sample liquid after blood routine analysis by the blood routine analysis device.
9. The method of cleaning a sample analyzer of claim 8, comprising: the controller sends a cleaning signal after the latex immunoassay is completed, and the hemolytic agent supply mechanism obtains hemolytic agent after receiving the cleaning signal and supplies the hemolytic agent to the latex immunoassay device to clean reaction residues of the latex immunoassay device; or
The controller sends a cleaning signal after the latex immunoassay is completed and sends a liquid taking signal after the blood routine analysis is completed, and the test liquid supply mechanism obtains test liquid after the blood routine analysis to the latex immunoassay device to clean reaction residues of the latex immunoassay device after receiving the cleaning signal and the liquid taking signal.
10. Use of a post-routine blood analysis sample containing a haemolysing agent component for washing reaction residues generated during a latex immunoassay.
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| CN110749730B (en) * | 2018-07-23 | 2023-09-15 | 深圳市帝迈生物技术有限公司 | Sample analysis device and cleaning method thereof |
| CN110871202A (en) * | 2018-08-31 | 2020-03-10 | 深圳市帝迈生物技术有限公司 | Sampling needle cleaning method and blood cell analyzer |
| CN111239027A (en) * | 2020-01-22 | 2020-06-05 | 深圳市锦瑞生物科技有限公司 | Blood particle detection method and blood analyzer |
| CN113311163B (en) * | 2020-02-26 | 2024-04-12 | 深圳迈瑞生物医疗电子股份有限公司 | Cleaning method of detection pool |
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| CN105728069B (en) * | 2016-01-30 | 2021-01-19 | 深圳市安测健康信息技术有限公司 | Multi-channel micro-fluidic chip for rapidly self-checking blood |
| CN105784571B (en) * | 2016-02-29 | 2023-05-26 | 深圳市帝迈生物技术有限公司 | Double-pool measuring method and device for specific reaction protein CRP |
| CN105699380A (en) * | 2016-03-23 | 2016-06-22 | 深圳市帝迈生物技术有限公司 | Analysis equipment and method for simultaneously measuring CRP (C-Reactive Protein) and blood routine |
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2016
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