CN107638404A - A kind of norfloxacin capsule and preparation method thereof - Google Patents
A kind of norfloxacin capsule and preparation method thereof Download PDFInfo
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- CN107638404A CN107638404A CN201710404151.7A CN201710404151A CN107638404A CN 107638404 A CN107638404 A CN 107638404A CN 201710404151 A CN201710404151 A CN 201710404151A CN 107638404 A CN107638404 A CN 107638404A
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- parts
- norfloxacin
- silica
- dextrin
- hydroxypropylcellulose
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Abstract
A kind of norfloxacin capsule and preparation method thereof.Raw material is composed of the following components in parts by weight：10 20 parts of ambroxol hydrochloride, 20 80 parts of lactose, 10 60 parts of cornstarch, 2 parts of silica 1,0.5 1 parts of magnesium stearate.The Ambroxol Hydrochloride Tablets composition quality that the present invention obtains is controllable, reaches and advantage of the reference preparation dissolution with similitude with the characteristics of very Fast Stripping compared with domestic marketed tablet.
Description
Technical field
The invention belongs to field of pharmaceutical preparations.Specifically, the present invention relates to a kind of norfloxacin capsule and its preparation side
Method.
Background technology
The entitled fluoro- Isosorbide-5-Nitraes of 1- ethyls -6--dihydro -4- oxos -7- (1- the piperazinyls) -3- quinoline carboxylic acids of Norfloxacin chemistry,
This product is second generation Comprecin, can hinder the effect of the DNA helicases of malignant bacteria in alimentary canal, hinders bacterium
DNA replication dna, there is inhibitory action to bacterium, be the common medicine for treating enteritis and dysentery and urinary infection.This medicine is to minor's bone
Bone influences whether to develop, therefore forbid minor to take formed with retarding action.Existing capsule auxiliary material easily occurs with Norfloxacin
Reaction.Its chemical formula structure formula is：
The content of the invention
It is an object of the invention to provide a kind of norfloxacin capsule and preparation method thereof, capsule auxiliary material is not sent out with Norfloxacin
Raw reaction.
To achieve the above object, the present invention uses following technical scheme：
A kind of norfloxacin capsule, including Norfloxacin and auxiliary material, auxiliary material are composed of the following components in parts by weight：Form sediment
Powder 50-100 parts, dextrin 10-30 parts, low substitution-hydroxypropylcellulose 5-35 parts, -2 parts of silica 1.
Preferably, the auxiliary material is composed of the following components in parts by weight：80 parts of starch, 20 parts of dextrin, low substitution-hydroxyl
Third 14 parts of cellulose, 2 parts of silica.
Present invention also offers a kind of preparation method of norfloxacin capsule, following steps are specifically included：
A. dispensing：By starch, dextrin, low substitution-hydroxypropylcellulose, silica and other pharmaceutically acceptable auxiliary materials
Sieving, and be sufficiently mixed；
B. slurrying：Hydroxypropyl methylcellulose is added into appropriate hot water to disperse, until all dissolving and being well mixed, then to add
Appropriate purified water；
C. softwood processed：It is fine with hydroxypropyl first after Norfloxacin, starch, dextrin, low substitution-hydroxypropylcellulose are well mixed
Tie up plain solution and carry out softwood processed for adhesive；
D. made softwood is pelletized with 20 mesh sieves, and dried in Turbogrid oven；
E. it is total mixed：By dry particle with 24 mesh whole grains, and add silica and be mixed with uniformly.
Preferably, in the step A, other pharmaceutically acceptable auxiliary materials include microcrystalline cellulose and magnesium stearate.
Embodiment
In order to which the present invention is apparent to understand, with reference to specific embodiment, the invention will be further described, to help
Understand present disclosure.
Embodiment one
First, it is formulated
Preparation method：Supplementary material is disposed by sieving, weighs Norfloxacin, starch respectively by recipe requirements, dextrin, low takes
Generation-hydroxypropylcellulose, hydroxypropyl methylcellulose solution is added thereto softwood processed, pressed《YK-160 oscillating granulator standard operations
Code》(SOP-P-2319) operated, softwood is transferred to through oscillating granulator with 20 mesh nylon screen wet granulars, wet grain
In Turbogrid oven, according to《The Turbogrid oven standard practice instructions of CTG-Z- II》(SOP-P-2079) operated, dry temperature
60 DEG C of degree, particle drying 2 hours, take out, with 24 mesh sieve whole grains, add silica and always mix.
Embodiment two
First, it is formulated
2nd, preparation method
Preparation method：Supplementary material is disposed by sieving, weighs Norfloxacin, starch respectively by recipe requirements, dextrin, low takes
Generation-hydroxypropylcellulose, hydroxypropyl methylcellulose solution is added thereto softwood processed, pressed《YK-160 oscillating granulator standard operations
Code》(SOP-P-2319) operated, softwood is transferred to through oscillating granulator with 20 mesh nylon screen wet granulars, wet grain
In Turbogrid oven, according to《The Turbogrid oven standard practice instructions of CTG-Z- II》(SOP-P-2079) operated, dry temperature
60 DEG C of degree, particle drying 2 hours, take out, with 24 mesh sieve whole grains, add silica and always mix.
Embodiment three
First, it is formulated
General principle, principal character and the advantages of the present invention of the present invention, the technology of the industry has been shown and described above
Personnel under the premise without departing from the spirit and scope of the present invention, can also it will be appreciated that the present invention is not limited to the above embodiments
There are various changes and modifications, these changes and improvement all fall within the protetion scope of the claimed invention.
Claims (4)
1. a kind of norfloxacin capsule, it is characterised in that including Norfloxacin and auxiliary material, auxiliary material is in parts by weight by with the following group
It is grouped into：Starch 50-100 parts, dextrin 10-30 parts, low substitution-hydroxypropylcellulose 5-35 parts, -2 parts of silica 1.
2. norfloxacin capsule according to claim 1, it is characterised in that the auxiliary material is in parts by weight by with the following group
It is grouped into：80 parts of starch, 20 parts of dextrin, 14 parts of low substitution-hydroxypropylcellulose, 2 parts of silica.
3. a kind of preparation method of norfloxacin capsule, it is characterised in that specifically include following steps：
A. dispensing：By starch, dextrin, low substitution-hydroxypropylcellulose, silica and other pharmaceutically acceptable auxiliary material mistakes
Sieve, and be sufficiently mixed；
B. slurrying：Hydroxypropyl methylcellulose is added into appropriate hot water to disperse, until all dissolving and being well mixed, then to add appropriate
Purified water；
C. softwood processed：After Norfloxacin, starch, dextrin, low substitution-hydroxypropylcellulose are well mixed, hydroxypropyl methylcellulose is used
Solution is that adhesive carries out softwood processed；
D. pelletize：Made softwood is pelletized with 20 mesh sieves, and dried in Turbogrid oven；
E. it is total mixed：By dry particle with 24 mesh whole grains, and add silica and be mixed with uniformly.
4. according to the method for claim 3, it is characterised in that in the step A, other pharmaceutically acceptable accessory packages
Include microcrystalline cellulose and magnesium stearate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710404151.7A CN107638404A (en) | 2017-06-01 | 2017-06-01 | A kind of norfloxacin capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710404151.7A CN107638404A (en) | 2017-06-01 | 2017-06-01 | A kind of norfloxacin capsule and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107638404A true CN107638404A (en) | 2018-01-30 |
Family
ID=61110240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710404151.7A Pending CN107638404A (en) | 2017-06-01 | 2017-06-01 | A kind of norfloxacin capsule and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN107638404A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108159017A (en) * | 2018-03-16 | 2018-06-15 | 安徽新世纪药业有限公司 | A kind of Levofloxacin Hydrochloride Capsules and preparation method thereof |
| CN108159018A (en) * | 2018-03-16 | 2018-06-15 | 安徽新世纪药业有限公司 | A kind of compound norfloxacin capsule and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247387A (en) * | 2011-03-21 | 2011-11-23 | 陕西宏府怡悦制药有限公司 | Norfloxacin phenazopyridine tablets and preparation process method and use thereof |
| WO2013103537A1 (en) * | 2012-01-04 | 2013-07-11 | Momentive Performance Materials Inc. | Silicone adhesive compositions |
| CN104606165A (en) * | 2015-02-04 | 2015-05-13 | 上海华源安徽仁济制药有限公司 | Norfloxacin capsules and preparation method thereof |
| CN105343028A (en) * | 2015-11-25 | 2016-02-24 | 万邦德制药集团股份有限公司 | Medicine composition with norfloxacin and method for preparing medicine composition |
| CN105982878A (en) * | 2015-03-06 | 2016-10-05 | 上海禾丰制药有限公司 | Norfloxacin capsules and preparation method thereof |
| CN106389376A (en) * | 2016-08-31 | 2017-02-15 | 安徽省润生医药股份有限公司 | Norfloxacin capsules and preparation method thereof |
-
2017
- 2017-06-01 CN CN201710404151.7A patent/CN107638404A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247387A (en) * | 2011-03-21 | 2011-11-23 | 陕西宏府怡悦制药有限公司 | Norfloxacin phenazopyridine tablets and preparation process method and use thereof |
| WO2013103537A1 (en) * | 2012-01-04 | 2013-07-11 | Momentive Performance Materials Inc. | Silicone adhesive compositions |
| CN104606165A (en) * | 2015-02-04 | 2015-05-13 | 上海华源安徽仁济制药有限公司 | Norfloxacin capsules and preparation method thereof |
| CN105982878A (en) * | 2015-03-06 | 2016-10-05 | 上海禾丰制药有限公司 | Norfloxacin capsules and preparation method thereof |
| CN105343028A (en) * | 2015-11-25 | 2016-02-24 | 万邦德制药集团股份有限公司 | Medicine composition with norfloxacin and method for preparing medicine composition |
| CN106389376A (en) * | 2016-08-31 | 2017-02-15 | 安徽省润生医药股份有限公司 | Norfloxacin capsules and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108159017A (en) * | 2018-03-16 | 2018-06-15 | 安徽新世纪药业有限公司 | A kind of Levofloxacin Hydrochloride Capsules and preparation method thereof |
| CN108159018A (en) * | 2018-03-16 | 2018-06-15 | 安徽新世纪药业有限公司 | A kind of compound norfloxacin capsule and preparation method thereof |
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| WD01 | Invention patent application deemed withdrawn after publication | ||
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Application publication date: 20180130 |