CN107626048A - A kind of toy integration radiotherapy system of fusion CT and PET bimodal images guiding - Google Patents
A kind of toy integration radiotherapy system of fusion CT and PET bimodal images guiding Download PDFInfo
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Abstract
The invention provides a kind of toy integration radiotherapy system of fusion CT and PET bimodal images guiding, belongs to detection imaging device technical field.The system includes PET imaging systems, X ray CT imaging system, animal bed system, thing to be detected, radiotherapy system, data collecting system, control system and computer.The system combines the advantages of CT and PET double-mode imagings, the molecular image information provided using the high-resolution anatomical structure image and PET imagings of CT imagings, to realize being accurately positioned for tumour, and the system is the integral system of image guiding and radiotherapy, realize the accurate radiotherapy of tumour, the monitoring and evaluation of molecular level is also carried out to tumor radiotherapy effect simultaneously, efficient pre- clinical research platform is provided for tumour radiotherapy research, bridge is established for zoopery and clinical conversion, accelerates clinical conversion process.
Description
Technical field
The invention belongs to detect imaging device technical field, and in particular to one kind fusion CT and PET bimodal image guiding
Toy integration radiotherapy system.
Background technology
Toy novel radiation treatment technique study with test in there is vital effect, especially cellular level without
In the case that method is simulated and can not carry out human trial, the Bystander effect of influence, Large Dose Irradiation induction such as tumor microenvironment,
The influence of gene expression, the optimal time point of radiotherapy combined immunization therapy, the radiotherapy side effect etc. of normal structure.It is but small at present
Widely used large area, the radiotherapy irradiation mode of injection wire harness in animal radiotherapy experiment, this and the three-dimensional used in clinical radiation therapy
Image guides accurate local radiotherapy technology to differ greatly.Due to there is no image guiding function, tumor region can not be accurately positioned, is led
Cause normal tissue radiological dose too high, thus can not accurate evaluation novel radiation treatment method effect, in particular in situ or
The radiological dose research of spontaneous tumor model, three-dimensional focus on radiotherapeutic effect research and combine radiotherapy and targeted drug treatment
Recruitment evaluation etc..
In order to overcome the difference of toy radiotherapy technology and clinical radiation therapy, the experimental result that toy radiotherapy is studied is set more may be used
Lean on and clinical test can be instructed, several research teams take up to research and develop in the world and clinical radiation therapy is intimate, has
There is the special toy radiotherapy system of CT or Cone-Beam CT (Cone-beam CT, CBCT) guiding function, including：U.S. John Hope
John of Jin Si universities et al. have developed the integrated toy radiotherapy system with CBCT image guiding functions；U.S. Stamford
Zhou of university et al. adds two-dimensional movement platform and variable aperture ray collimator on the basis of commercial microCT, realizes
There is the toy radiotherapy of CT guiding functions；Canadian Jensen et al. has manufactured and designed the orthogonal hinge of computer control
Collimater, toy CT imaging systems radiotherapy system is transformed into；The Zhang in the U.S. et al. utilizes carbon nano-tube x-ray battle array
Row have built microray beam radiotherapy system；2015, German Felix et al. collimated also by the ray for increasing replaceable aperture
Device is by the industrial microCT system reforms into the toy radiotherapy system with image guiding function；It is 2016, German
Tillner et al. has built the non-profit petty action object image guiding with CBCT guiding functions using bifocus X ray bulb to be put
Treatment system SAIGRT；The same year, the Yang in the U.S. et al. has also reported the animals stereo radiotherapy with CBCT image guiding functions
System iSMAART, the system carry out CBCT imagings and three-dimensional radiotherapy by rotating the mouse of orthostatism.In addition,
Commercialized toy radiotherapy system has two, i.e. toy radiotherapy system SARRP, the Canadian PXI of U.S. Xstrahl companies
The toy radiotherapy system X-RAD 225Cx of company.But there is not yet now a has CT and PET double-mode imaging functions
And for guiding the integral system of the accurate radiotherapy of toy.
Although CT or CBCT have the function that in the accurate radiotherapy of toy it is indispensable, CBCT is to soft tissue
Contrast is poor, can not clearly differentiate the position of the in situ tumors such as brain, liver, pancreas, prostate, and CT can not also detect radiotherapy
For tumour in the response of cell and molecular level, this undoubtedly constrains the implementation of accurate radiotherapy and the assessment of radiotherapeutic effect afterwards.
PET (Positron Emission Tomography, positron emission tomography) be it is a kind of have it is three-dimensional into
As the molecular image imaging technique of ability, high sensitivity, penetration depth is deep, and can be in the horizontal change of body molecular detection.
PET imagings guide PET imaging techniques for image with positioning tumor position and the ability for disclosing tumor-related molecules information
In radiotherapy research, deficiencies of the CBCT in terms of it can not recognize low contrast tumor target on the one hand can be made up, on the other hand may be used
With by the method for image body disclose radiotherapy before and after tumour cell and molecule change, so as to detect and evaluate radiotherapy effect
Fruit.
The content of the invention
It is an object of the invention to provide a kind of toy one chemoradiotherapy system of fusion CT and PET bimodal images guiding
System, the deficiency of existing single CT guiding toy radiotherapy system is compensate for, is drawn simultaneously using molecular image PET and structure imaging CT
Radiotherapy is led, and the radial location degree of accuracy of target is improved by various sizes of ray collimator, realizes tumor target
Precise positioning and radiotherapy, and PET image supervisory controls and evaluation radiotherapeutic effect can be passed through so that experimental result is more accurate, more may be used
Lean on.
Technical scheme：
A kind of toy integration radiotherapy system of fusion CT and PET bimodal images guiding, including：PET imaging systems
1st, X ray CT imaging system 2, animal bed system 3, thing to be detected 4, radiotherapy system 5, data collecting system, control system and meter
Calculation machine；
Described data collecting system and control system is connected to computer；PET imaging systems 1 and X ray CT imaging
System 2 is all connected with data collecting system, by the data transfer of collection PET imaging systems 1 and X ray CT imaging system 2 to calculating
Machine is handled；Animal bed system 3 and radiotherapy system 5 are all connected with control system, for controlling the motion of animal bed system 3 and putting
The angle and dosage for the treatment of system 5；
PET imaging systems 1, X ray CT imaging system 2 and radiotherapy system 5 share animal bed system 3, X ray CT imaging system
2 central axis of uniting overlap with the central axis of PET imaging systems 1, as axis 6；
Described PET imaging systems 1 are uniformly fixed with even numbered blocks flat board PET for hollow cylindrical, hollow space inwall
Detector, form imaging hole；Thing 4 to be detected is moved in imaging hole by animal bed system 3 to be imaged, flat board PET detections
Device is used to detect the gammaphoton launched after the injection of thing 4 nucleic to be detected；
Described X ray CT imaging system 2 includes X-ray flat panel detector 21 and Microfocus X-ray x-ray source 22, and X ray is put down
Partitioned detector 21 and Microfocus X-ray x-ray source 22 are symmetrically positioned in the both sides of animal bed system 3, highly maintain an equal level with the top of fixed support 35；
The detection signal that Microfocus X-ray x-ray source 22 is launched is monitored by thing 4 to be detected by X-ray flat panel detector 21, X ray flat board
The visual field center of detector 21 is detection zone, obtains 360 ° of radioscopic image and is rebuild for CT；
Described animal bed system 3 includes horizontal shifting platform 31, moves horizontally sliding block 32, vertical shift platform 33, rotation
Turn platform 34 and fixed support 35；Horizontal shifting platform 31, move horizontally sliding block 32, vertical shift platform 33, rotation platform 34,
Fixed support 35 is fixed successively from top to bottom；Move horizontally sliding block 32 to slide along horizontal shifting platform 31 is horizontal, vertical shift
Platform 33 is slided along vertical direction moving horizontally sliding block 32, for adjusting the position of thing 4 to be detected；Rotation platform 34 is circle
Shape platform；Thing 4 to be detected is placed on fixed support 35, and rotation platform 34 drives fixed support 35 to be rotated along central shaft；Calculate
Machine controlled level mobile platform 31, move horizontally sliding block 32 and vertical shift platform 33 thing 4 to be detected is moved to detection zone；
Described radiotherapy system 5 includes sigmatron bulb 51, one-level collimater 52, secondary collimator 53, fastening screw
54th, replaceable collimater 55 and swivel mount 56；
Described one end of swivel mount 56 is fixed on the rotary shaft, and the other end is connected with the fixing end of sigmatron bulb 51, high
The transmitting terminal of energy X ray bulb 51 is fixedly connected sequentially with one-level collimater 52, secondary collimator 53 and replaceable collimater 55,
The axis of one-level collimater 52, secondary collimator 53 and replaceable collimater 55 and the center overlapping of axles of rotation platform 34；
X-ray power that sigmatron bulb 51 is launched is big, focus is big, and one-level collimater 52 is used to tentatively constraining high
The X-ray beam of the transmitting of energy X ray bulb 51；The X ray that further constraint constrains by one-level collimater 52 of secondary collimator 53
Beam；The shape of final X-ray beam is determined finally by replaceable collimater 55.Swivel mount 56 rotates around axis 6, Ke Yicong
Treat detectable substance 4 for 360 ° and carry out radiotherapy.By the translation and rotation of animal bed system 3, radiotherapy system 5 can treat detectable substance 4
Single angle radiotherapy at any angle is carried out, animal bed system 3 can also be surrounded and carry out 360 ° of space-focusing radiotherapies.
Including CT image processing platforms, PET image processing platform, Radiotherapy dosimetry plan platform and image in computer can
Depending on changing platform；CT image processing platforms, the data for X-ray detector to be gathered carry out CT image reconstructions.PET image processing
Platform, for handling data that pet detector collects and carrying out PET image reconstruction.Radiotherapy dosimetry plan platform, for image
Radiotherapy localization is guided to be planned with Radiotherapy dosimetry.CT images and PET image are used for the accurate location for determining tumour, Radiotherapy dosimetry plan
Platform calculates position and the time of launch of the radiation frame of radiotherapy system according to dose requirements.Image viewing platform, is used for
Visualization, fusion and the analysis of CT, PET and Radiotherapy dosimetry image.
Described replaceable collimater 55 includes circular replaceable collimater 551, the replaceable collimater 552 of square and length
Square replaceable collimater 553.The interior shape of circular replaceable collimater 551 is circle, and final beam shape is circle；Just
The interior shape of square replaceable collimater 552 is square, and final beam shape is square；The replaceable collimater of rectangle
553 interior shape is rectangle, and final beam shape is rectangle, basis can be actually needed selection more in the specific implementation
Change.
Replaceable collimater 55 is fixed in secondary collimator 53 by fastening screw 54, can be loaded and unloaded and be changed collimater 55；
Sigmatron bulb 51 is Microfocus X-ray bulb, sheet metal is provided with front of delivery outlet, for filtering out low-energy X-ray.
Beneficial effects of the present invention：The present invention combines the advantages of CT and PET double-mode imagings, the high-resolution being imaged using CT
The molecular image information that anatomical structure image and PET imagings provide, to realize being accurately positioned for tumour, and the system is image
Guiding and the integral system of radiotherapy, it is possible to achieve the accurate radiotherapy of tumour, while tumor radiotherapy effect can also be divided
Sub horizontal monitoring and evaluation, efficiently pre- clinical research platform is provided for tumour radiotherapy research, be zoopery with facing
Bridge is established in bed conversion, accelerates clinical conversion process.
Brief description of the drawings
Fig. 1 is one embodiment of the CT and PET bimodal images guiding toy integration radiotherapy system of the present invention
The front view of structural representation.
Fig. 2 is one embodiment of the CT and PET bimodal images guiding toy integration radiotherapy system of the present invention
The top view of structural representation.
Fig. 3 is the structural representation of one embodiment of the PET imaging systems of the present invention.
Fig. 4 a are the left views of the radiotherapy system of the present invention.
Fig. 4 b are the front views of the radiotherapy system of the present invention.
Fig. 5 a are the structural representation of the circular replaceable collimation head of the radiotherapy system of the present invention.
Fig. 5 b are the structural representation of the square replaceable collimation head of the radiotherapy system of the present invention.
Fig. 5 c are the structural representation of the replaceable collimation head of the rectangle of the radiotherapy system of the present invention.
Fig. 6 is the structural representation of one embodiment of the PET and CT termed image-guided radiotherapies of the present invention.
In figure：1PET imaging systems；2X ray CT imaging systems；3 animal bed systems；4 things to be detected；5 radiotherapy systems；6
Axis；21X ray flat panel detectors；22 Microfocus X-ray x-ray sources；31 horizontal shifting platforms；32 move horizontally sliding block；33 vertical shiftings
Moving platform；34 rotation platforms；35 fixed supports；51 sigmatron bulbs；52 one-level collimaters；53 secondary collimators；54 fastenings
Screw；55 replaceable collimaters；56 swivel mounts；551 circular replaceable collimaters；The 552 replaceable collimaters of square；553 length
Square replaceable collimater.
Embodiment
Describe the embodiment of the present invention in detail below in conjunction with technical scheme and accompanying drawing.
With reference to Fig. 1~Fig. 5, a kind of toy integration radiotherapy system of fusion CT and PET bimodal images guiding, including
PET imaging systems 1, X ray CT imaging system 2, animal bed system 3, thing to be detected 4, radiotherapy system 5, data collecting system, control
System processed and computer；
Described data collecting system and control system is connected to computer；PET imaging systems 1 and X ray CT imaging
System 2 is all connected with data collecting system, by the data transfer of collection PET imaging systems 1 and X ray CT imaging system 2 to calculating
Machine is handled；Animal bed system 3 and radiotherapy system 5 are all connected with control system, for controlling the motion of animal bed system 3 and putting
The angle and dosage for the treatment of system 5；
PET imaging systems 1, X ray CT imaging system 2 and radiotherapy system 5 share animal bed system 3, X ray CT imaging system
2 central axis of uniting overlap with the central axis of PET imaging systems 1, as axis 6；
Described PET imaging systems 1 are uniformly fixed with even numbered blocks flat board PET for hollow cylindrical, hollow space inwall
Detector, form imaging hole；Thing 4 to be detected is moved in imaging hole by animal bed system 3 to be imaged, flat board PET detections
Device is used to detect the gammaphoton launched after the injection of thing 4 nucleic to be detected；
Described X ray CT imaging system 2 includes X-ray flat panel detector 21 and Microfocus X-ray x-ray source 22, and X ray is put down
Partitioned detector 21 and Microfocus X-ray x-ray source 22 are symmetrically positioned in the both sides of animal bed system 3, highly maintain an equal level with the top of fixed support 35；
The detection signal that Microfocus X-ray x-ray source 22 is launched is monitored by thing 4 to be detected by X-ray flat panel detector 21, X ray flat board
The visual field center of detector 21 is detection zone, obtains 360 ° of radioscopic image and is rebuild for CT；
Described animal bed system 3 includes horizontal shifting platform 31, moves horizontally sliding block 32, vertical shift platform 33, rotation
Turn platform 34 and fixed support 35；Horizontal shifting platform 31, move horizontally sliding block 32, vertical shift platform 33, rotation platform 34,
Fixed support 35 is fixed successively from top to bottom；Move horizontally sliding block 32 to slide along horizontal shifting platform 31 is horizontal, vertical shift
Platform 33 is slided along vertical direction moving horizontally sliding block 32, for adjusting the position of thing 4 to be detected；Rotation platform 34 is circle
Shape platform；Thing 4 to be detected is placed on fixed support 35, and rotation platform 34 drives fixed support 35 to be rotated along central shaft；Calculate
Machine controlled level mobile platform 31, move horizontally sliding block 32 and vertical shift platform 33 thing 4 to be detected is moved to detection zone；
Described radiotherapy system 5 includes sigmatron bulb 51, one-level collimater 52, secondary collimator 53, fastening screw
54th, replaceable collimater 55, replaceable collimater 55 and swivel mount 56；
Described one end of swivel mount 56 is fixed on the rotary shaft, and the other end is connected with the fixing end of sigmatron bulb 51, high
The transmitting terminal of energy X ray bulb 51 is fixedly connected sequentially with one-level collimater 52, secondary collimator 53 and replaceable collimater 55,
The axis of one-level collimater 52, secondary collimator 53 and replaceable collimater 55 and the center overlapping of axles of rotation platform 34；
X-ray power that sigmatron bulb 51 is launched is big, focus is big, and one-level collimater 52 is used to tentatively constraining high
The X-ray beam of the transmitting of energy X ray bulb 51；The X ray that further constraint constrains by one-level collimater 52 of secondary collimator 53
Beam；The shape of final X-ray beam is determined finally by replaceable collimater 55.Swivel mount 56 rotates around axis 6, Ke Yicong
Treat detectable substance 4 for 360 ° and carry out radiotherapy.By the translation and rotation of animal bed system 3, radiotherapy system 5 can treat detectable substance 4
Single angle radiotherapy at any angle is carried out, animal bed system 3 can also be surrounded and carry out 360 ° of space-focusing radiotherapies.
Including CT image processing platforms, PET image processing platform, Radiotherapy dosimetry plan platform and image in computer can
Depending on changing platform；CT image processing platforms, the data for X-ray detector to be gathered carry out CT image reconstructions.PET image processing
Platform, for handling data that pet detector collects and carrying out PET image reconstruction.Radiotherapy dosimetry plan platform, for image
Radiotherapy localization is guided to be planned with Radiotherapy dosimetry.CT images and PET image are used for the accurate location for determining tumour, Radiotherapy dosimetry plan
Platform calculates position and the time of launch of the radiation frame of radiotherapy system according to dose requirements.Image viewing platform, is used for
Visualization, fusion and the analysis of CT, PET and Radiotherapy dosimetry image.
Described replaceable collimater 55 includes circular replaceable collimater 551, the replaceable collimater 552 of square and length
Square replaceable collimater 553.The interior shape of circular replaceable collimater 551 is circle, and final beam shape is circle；Just
The interior shape of square replaceable collimater 552 is square, and final beam shape is square；The replaceable collimater of rectangle
553 interior shape is rectangle, and final beam shape is rectangle, basis can be actually needed selection more in the specific implementation
Change.
Replaceable collimater 55 is fixed in secondary collimator 53 by fastening screw 54, can be loaded and unloaded and be changed collimater 55；
Sigmatron bulb 51 is Microfocus X-ray bulb, sheet metal is provided with front of delivery outlet, for filtering out low-energy X-ray.X ray
The outside of CT imaging systems 2 is equipped with stereotype, prevents X ray from revealing.
As shown in fig. 6, when PET is imaged, sliding block 32 is moved horizontally to left movement, thing 4 to be detected is moved to PET imagings
It is imaged in the areas imaging of system 1.After PET imagings terminate, move horizontally sliding block 32 and move horizontally to the right, by thing to be detected
4 are moved in the areas imaging of CT imaging systems 2, as shown in Figure 6.Then, rotation platform 34 carries out 360 ° around rotary shaft 36
Rotation, drives thing 4 to be detected to rotate, while Microfocus X-ray x-ray source 22 launches X ray, the acquired projections of X-ray flat panel detector 21
Image, for CT image reconstructions.
As shown in fig. 6, after CT imagings have been carried out, sliding block 32 is moved horizontally to left movement, thing 4 to be detected is moved to and put
Radiotherapy is carried out in the range for the treatment of system 5.By swivel mount 56, detectable substance 4 can be treated and carry out radiotherapy at any angle.Radiotherapy
When, the shape of radiotherapy ray is by circular replaceable collimater 551, the replaceable collimater 552 of square and the replaceable standard of rectangle
Straight device 553 determines, selects suitable replaceable collimater, unclamps and then tighten fastening bolt 54, you can fixed replaceable collimation
Device.
As shown in fig. 6, in Patients During Radiotherapy, tumor target is determined by PET and CT images.X ray CT imaging system 2 obtains
CT images the anatomical structure image of thing 4 to be detected is provided, the PET image that PET imaging systems 1 obtain provides thing 4 to be detected
Function image.Because PET imaging systems 1 and X ray CT imaging system 2 are blended in same system and share same imaging axis, make
Obtain image co-registration very accurately, conveniently.Radiological dose Optimization Platform, by the fusion and analysis of CT images and PET image, accurately
The position of positioning tumor, and dosage as requested, Radiotherapy dosimetry planning is carried out, provides radiotherapy angle and time of launch.
As shown in fig. 6, in Patients During Radiotherapy, radiotherapy system 5 can treat detectable substance 4 by the rotation of rotary frame 56 and enter
Row angular emission single at any angle；Rotation platform 34 and the Union Movement of rotary frame 56 can also be realized and treat detectable substance 4
The accurate radiotherapy of space multistory of internal radiotherapy target, increase the radiological dose of radiotherapy target area, and reduction pair to greatest extent
The irradiation of normal structure.
Further, the present invention is individually imaged available for any PET or CT, it can also be used to non-image guiding radiotherapy, or it is single
Only CT termed image-guided radiotherapies.When being imaged to living small animal progress PET and CT bimodals and guiding integral chemoradiotherapy, will anaesthetize
Living small animal afterwards is fixed on animal bed system, and molecular probe is injected in the tested inspection body of thing 4.Molecular probe be for
The radionuclide of PET imagings, CT enhancing contrast agent can also be used according to actual requirement.After probe injection certain time, adjust
The position of whole animal beds, tested animal are moved to corresponding imaging region and carry out PET imagings and CT imagings successively.Respectively by PET
Respective imaging method is carried out with the data of CT imaging systems and carries out image reconstruction, finally carries out same machine image registration with merging, really
Determine the position of radiotherapy target, (single radiation exposure, multiray irradiate radiological dose planning system according to radiological dose and radial pattern
Or space multistory irradiation), optimization calculates angle and the radiation exposure time of radiation.
It is new particularly suitable for studying, testing based on the toy integration radiotherapy system of PET and CT bimodal images guiding
Type radiotheraping method, especially in the case where cellular level can not simulate and can not carry out human trial, such as tumor microenvironment
Influence, the Bystander effect of Large Dose Irradiation induction, the influence of gene expression, the optimal time point of radiotherapy combined immunization therapy, just
Radiotherapy side effect often organized etc..
Claims (8)
1. a kind of toy integration radiotherapy system of fusion CT and PET bimodal images guiding, it is characterised in that described is small
Animal integration radiotherapy system includes PET imaging systems (1), X ray CT imaging system (2), animal bed system (3), to be detected
Thing (4), radiotherapy system (5), data collecting system, control system and computer；
Described data collecting system and control system is connected to computer；PET imaging systems (1) and X ray CT imaging system
System (2) is all connected with data collecting system, and the data transfer for gathering PET imaging systems (1) and X ray CT imaging system (2) is arrived
Computer is handled；Animal bed system (3) and radiotherapy system (5) are all connected with control system, for controlling animal bed system (3)
Motion and radiotherapy system (5) angle and dosage；
Described PET imaging systems (1), X ray CT imaging system (2) and radiotherapy system (5) shares animal bed system (3), and X is penetrated
Line CT imaging systems (2) central axis overlaps with PET imaging systems (1) central axis, as axis (6)；
Described PET imaging systems (1) are uniformly fixed with even numbered blocks flat board PET spies for hollow cylindrical, hollow space inwall
Device is surveyed, forms imaging hole；Thing (4) to be detected is moved in imaging hole by animal bed system (3) to be imaged, and flat board PET is visited
Device is surveyed to be used to detect the gammaphoton launched after thing to be detected (4) injection nucleic；
Described X ray CT imaging system (2) includes X-ray flat panel detector (21) and Microfocus X-ray x-ray source (22), X ray
Flat panel detector (21) and Microfocus X-ray x-ray source (22) are symmetrically positioned in animal bed system (3) both sides, highly with fixed support (35)
Top maintains an equal level；The detection signal that Microfocus X-ray x-ray source (22) is launched is by thing to be detected (4) by X-ray flat panel detector
(21) monitor, the visual field center of X-ray flat panel detector (21) is detection zone, obtains 360 ° of radioscopic image for CT weights
Build；
Described animal bed system (3) includes horizontal shifting platform (31), moves horizontally sliding block (32), vertical shift platform
(33), rotation platform (34) and fixed support (35)；Horizontal shifting platform (31), move horizontally sliding block (32), vertical shift is put down
Platform (33), rotation platform (34), fixed support (35) are fixed successively from top to bottom；Sliding block (32) is moved horizontally along moving horizontally
Platform (31) is horizontal to be slided, and vertical shift platform (33) is slided along vertical direction moving horizontally sliding block (32), for adjusting
The position of thing (4) to be detected；Rotation platform (34) is circular platform；Thing (4) to be detected is placed on fixed support (35), rotary flat
Platform (34) drives fixed support (35) to be rotated along central shaft；Computer controlled level mobile platform (31), move horizontally sliding block
(32) and thing to be detected (4) is moved to detection zone by vertical shift platform (33)；
Described radiotherapy system (5) includes sigmatron bulb (51), one-level collimater (52), secondary collimator (53), fastening
Screw (54), replaceable collimater (55) and swivel mount (56)；
Described swivel mount (56) one end is fixed on the rotary shaft, and the other end is connected with sigmatron bulb (51) fixing end, high
The transmitting terminal and one-level collimater (52), secondary collimator (53) and replaceable collimater (55) of energy X ray bulb (51) are successively
It is fixedly connected, one-level collimater (52), the axis of secondary collimator (53) and replaceable collimater (55) and rotation platform
(34) center overlapping of axles.
2. a kind of toy integration radiotherapy system of fusion CT and PET bimodal images guiding as claimed in claim 1, its
It is characterised by, described replaceable collimater (55) is circular replaceable collimater (551), the replaceable collimater of square
Or the replaceable collimater of rectangle (553) (552)；The interior shape of circular replaceable collimater (551) is circular, final ray
It is shaped as circle；The interior shape of the replaceable collimater (552) of square is square, and final beam shape is square；It is long
The interior shape of square replaceable collimater (553) is rectangle, and final beam shape is rectangle, is selected according to being actually needed
Change.
A kind of 3. toy one chemoradiotherapy system of fusion CT and PET bimodal images guiding as claimed in claim 1 or 2
System, it is characterised in that described replaceable collimater (55) is fixed in secondary collimator (53) by fastening screw (54), can
Collimater (55) is changed in handling.
A kind of 4. toy one chemoradiotherapy system of fusion CT and PET bimodal images guiding as claimed in claim 1 or 2
System, it is characterised in that described sigmatron bulb (51) is Microfocus X-ray bulb, is provided with sheet metal in front of delivery outlet, is used for
Filter out low-energy X-ray.
5. a kind of toy integration radiotherapy system of fusion CT and PET bimodal images guiding as claimed in claim 3, its
It is characterised by, described sigmatron bulb (51) is Microfocus X-ray bulb, sheet metal is provided with front of delivery outlet, for filtering out
Low-energy X-ray.
6. the toy one chemoradiotherapy system of a kind of fusion CT and the guiding of PET bimodal images as described in claim 1,2 or 5
System, it is characterised in that include CT image processing platforms, PET image processing platform, Radiotherapy dosimetry plan in described computer
Platform and image viewing platform；CT image processing platforms, the data for X-ray detector to be gathered carry out CT image weights
Build；PET image processing platform, for handling data that pet detector collects and carrying out PET image reconstruction；Radiotherapeutic agents gauge
Platform is drawn, is planned for termed image-guided radiotherapy positioning with Radiotherapy dosimetry；CT images and PET image are used for the accurate position for determining tumour
Put, Radiotherapy dosimetry plan platform calculates position and the time of launch of the radiation frame of radiotherapy system according to dose requirements；Image
Visualization Platform, visualization, fusion and analysis for CT, PET and Radiotherapy dosimetry image.
7. a kind of toy integration radiotherapy system of fusion CT and PET bimodal images guiding as claimed in claim 3, its
It is characterised by, CT image processing platforms, PET image processing platform, Radiotherapy dosimetry plan platform is included in described computer
With image viewing platform；CT image processing platforms, the data for X-ray detector to be gathered carry out CT image reconstructions；PET
Image processing platform, for handling data that pet detector collects and carrying out PET image reconstruction；Radiotherapy dosimetry plan platform,
Planned for termed image-guided radiotherapy positioning with Radiotherapy dosimetry；CT images and PET image are used for the accurate location for determining tumour, radiotherapy
Dose plan platform calculates position and the time of launch of the radiation frame of radiotherapy system according to dose requirements；Image viewing
Platform, visualization, fusion and analysis for CT, PET and Radiotherapy dosimetry image.
8. a kind of toy integration radiotherapy system of fusion CT and PET bimodal images guiding as claimed in claim 4, its
It is characterised by, CT image processing platforms, PET image processing platform, Radiotherapy dosimetry plan platform is included in described computer
With image viewing platform；CT image processing platforms, the data for X-ray detector to be gathered carry out CT image reconstructions；PET
Image processing platform, for handling data that pet detector collects and carrying out PET image reconstruction；Radiotherapy dosimetry plan platform,
Planned for termed image-guided radiotherapy positioning with Radiotherapy dosimetry；CT images and PET image are used for the accurate location for determining tumour, radiotherapy
Dose plan platform calculates position and the time of launch of the radiation frame of radiotherapy system according to dose requirements；Image viewing
Platform, visualization, fusion and analysis for CT, PET and Radiotherapy dosimetry image.
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| WO2019196767A1 (en) * | 2018-04-11 | 2019-10-17 | 西安大医集团有限公司 | Image-guided radiotherapy device |
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| CN114515162B (en) * | 2022-01-29 | 2024-05-28 | 中国人民解放军空军军医大学 | X-ray multifunctional imaging treatment integrated machine and X-ray diagnosis and treatment equipment |
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