CN107550458A - The more characteristic imaging methods of biological tissue based on acoustoelectric effect and acoustic radiation force - Google Patents
The more characteristic imaging methods of biological tissue based on acoustoelectric effect and acoustic radiation force Download PDFInfo
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Abstract
The present invention relates to a kind of more characteristic imaging methods of biological tissue based on acoustoelectric effect and acoustic radiation force, including：Measurement focuses on the focal spot size in the focusing domain of ultrasonic transducer under ultrasonic perturbation mode, and determines to focus on scanning sequency of the ultrasonic wave to each focusing domain；Launch low intensive trace pulse to ultrasonic transducer, in the case of focus ultrasonic is ignored, obtain the echo-signal of boundary survey voltage vector φ and trace pulse；When exciting current reaches crest or trough times, the driving pulse of high intensity is launched to ultrasonic transducer so that ultrasonic transducer is launched and sweep mechanism is operated in and focused under ultrasonic perturbation mode, focuses on ultrasonic n-th of focusing domain of wave disturbance；While ultrasonic wave disturbance is focused on, measurement disturbance back boundary measurement voltage vector φn, and launch low intensive trace pulse, receives echo-signal to ultrasonic transducer again；Obtain n-th focusing domain acoustoelectric signal and with corresponding displacement information；Data processing is carried out to the data obtained, rebuilds biological tissue images.
Description
Technical field
The invention belongs to bio-imaging technical field, is related to from two angle comprehensive analysis groups of electrology characteristic and mechanical characteristic
The electrical characteristic parameter and the imaging technique of elastic characteristic knitted.
Background technology
Ultrasonic technology plays great effect in medical field, and it is in medical diagnosis and detection, therapeutic treatment and hand
Using quite varied in art.Because the Elasticity attribute of each several part in biological tissue's (particularly pathological tissues) has differences,
So tissue also differs to the response for applying excitation, the parameters such as displacement, strain, speed, shear wave velocity are mainly shown as
Distributional difference.Therefore, researchers are in communication theory in tissue of tissue elasticity theory of mechanics, ripple and signal transacting etc.
On the basis of study Ultrasonic Elasticity Imaging (Ultrasound Elastography).Communication process of the ultrasound in soft tissue
Middle absorption and reflection cause the change of energy density, thus produce radiant force, and acoustic radiation force produces two effects：First, axle
To compression stretching, produce displacement in the axial direction, propagated forward in a manner of compressional wave；Two be due to the shearing with laterally adjacent tissue
Stress, the shearing wave laterally propagated is produced, shows as horizontal each point chronological shear displacemant vertically.By ultrasound into
Image space method estimates the distribution situation of each parameter inside biological tissue, and then reflects the mechanical attributes such as soft tissue elasticity.Elasticity into
As technology can overcome the disadvantages that the deficiency of traditional medicine imaging means, there is very important clinical value and wide application prospect.
Research of the Ultrasonic Elasticity Imaging in imaging field is currently based on, mainly may be summarized to be the following aspects：
1st, there is low-frequency alternating radiant force caused by the focusing ultrasonic wave of small frequency difference using two beams, measures the amplitude of vibration
And phase information, the elastic characteristic of response organization；
2nd, tissue small position caused in the vertical is obtained using caused radiant force during ultrasonic propagation, measurement
Move；
3rd, using caused radiant force during ultrasonic propagation, monitoring tissue in the horizontal propagate by caused shearing wave.
At present in document, low-frequency alternating radiant force caused by the focusing ultrasonic wave that there is small frequency difference using two beams is referred to,
The amplitude and phase information of vibration are measured, reflects the elastic characteristic of tissue, 1998, Fatemi and Greenleaf (Fatemi
M,GreenleafJ,Ultrasound-stimulated vibro-acoustic spectrography,Science,1998,
280(5360):82) exist《Science》Acoustic vibration imaging (vibro-acoustic spectrography) is proposed in magazine,
Two beams of this method have small frequency difference Δ f focusing focusing ultrasonic wave in biological tissue's certain local location of inside, make focal zone
Inner tissue is produced vibration by the effect of low-frequency alternating radiant force, so as to which outside radiation frequency is that (generally hundreds of Hz are extremely by Δ f
Tens of kHz) sound wave, this sound wave contains the elastic information harmony dampening information of focal zone tissue, and available hydrophone connects
Receive, the signal received is used to be imaged the image that can obtain reflection tissue characteristics.
At present in document, using caused radiant force during ultrasonic propagation, measurement obtains tissue and produced in the vertical
Micro-displacement, 2002, Nightingale leader seminar (Nightingale K, Soo M S, Nightingale
R,Acoustic radiation force impulse imaging:in vivo demonstration of clinical
feasibility,Ultrasound in Medicine&Biology,2002,28(2):227) propose acoustic radiation force pulse into
Image space method (Acoustic radiation force impulse imaging, ARFI).Its general principle is：It is short by launching
When high intensity focus ultrasonic in regional area in tissue, produce acoustic radiation force, tissue is produced local vibration.Using traditional
Method (Doppler/pulse echo detection displacement) detection displacement of tissue, reflects its mechanical attribute.Each point in tissue is carried out successively
Scanning is focused on, and estimates displacement, you can to receive acoustic radiation force pulse diagram picture, the intensity of each pixel in image can be used most
Big displacement amplitude, the time for reaching maximum displacement amplitude or displacement recovery time represent.
At present in document, using caused radiant force during ultrasonic propagation, monitoring tissue is caused in the horizontal to cut
Cut ripple to propagate, 1998, Sarvazyan et al. (Sarvazyan A P, Rudenko O V, Swanson S D, Shear
wave elasticity imaging:a new ultrasonic technology of medical diagnostic,
Ultrasound in Medicine&Biology,1998,24(9):1419-1435) propose shearing wave elastograph imaging method
(Shear wave elasticity imaging,SWEI).This method produces shearing with high intensity focused ultrasound excitation tissue
Ripple, then it is monitored using propagation of the mr imaging technique to shearing wave, so as to realize quantitative point to soft tissue elasticity
Analysis.Afterwards, the research group of Nightingale leaders realizes is encouraged and monitoring shearing wave simultaneously with same ultrasonic transducer.With
ARFI is compared, and SWEI difference is detection process, and it is by monitoring the vibration position at different spatial point at different moments
Move, and then estimate the spread speed of shearing wave.
Similar with the elastic characteristic of biological tissue, electrical impedance characteristicses are electrology characteristics intrinsic in organism, in human body not
Same tissue (organ) has different electrology characteristics, and some pathological phenomenons and physiological activity can cause tissue electricity special
Property change, between some normal tissues and pathologic tissue, larger electrology characteristic difference, therefore biological tissue be present
Carry abundant physiology and pathological information.Electrical impedance tomography technology (Electrical Impedance
Tomography, EIT) it is the chromatography imaging technique based on electrical characteristics sensitive mechanism, it judges sensitivity field by electricity means
The electrical characteristics distribution of interior object, and then obtain the distributed image of the interior medium of this.It is but inverse due to EIT dielectric distribution image reconstructions
Problem has serious ill-posedness, causes reconstructed image spatial resolution and precision all very low, seriously limits answering for the technology
With and development.
Acoustic-electric imaging technique is a kind of imaging method of new multiple physical field coupling, is in the anti-tomography base of traditional resistor
Developed on plinth, by the coupling between electric field and sound field, increase effective information in organism.Acoustoelectric effect
The ultrasonic wave that (Acousto-Electric Interaction) refers to focus on causes pressure change in Medium Propagation, makes part
Region causes the period mechanical compression and relaxation determined by the frequency of ultrasonic wave, causes regional area to produce small elastic shape
Become, so that respective change occurs for local conductivity.
Research of the acoustic-electric imaging technique in imaging field is currently based on, mainly may be summarized to be the following aspects：
1st, based on acoustoelectric effect principle, focal zone local conductivity is changed, using focus on ultrasonic wave carrying
Positional information and the power of acoustoelectric signal are directly rebuild to object；
2nd, organism internal current source density is imaged using acoustoelectric effect principle.
At present in document, refer to and utilize the strong and weak directly to object of the positional information and acoustoelectric signal for focusing on ultrasonic wave carrying
Rebuild, Zhang in 2004 and Wang (Zhang H and Wang L V, Acousto-electric tomography,
《Proceedings of SPIE》,2004,5320:145-149) propose to utilize ultrasonic modulation electrical impedance tomography side first
((Ultrasound Modulated Electrical Impedance Tomography, UMEIT) is to the electricity of biological tissue for method
Impedance operator is implemented as picture, also known as acoustic-electric imaging (Acousto-Electrical Tomography, AET).Based on acoustoelectric effect
Principle, using focus on ultrasonic wave carrying positional information and acoustoelectric signal power directly object distribution of conductivity is carried out weight
Build.The EIT of high-contrast and high-resolution ultrasonic imaging method are combined by it, and base has been established in the development for acoustic-electric imaging
Plinth.2013 Chinese patent (CN 103156604A) biological tissue's electrical impedance imaging method of supersonic synergic is also disclosed.
Refer to the Current density imaging based on acoustoelectric effect in document at present, 2008, Olafsson R et al.
(Olafsson R,Witte R S,Huang S W,Ultrasound Current Source Density Imaging,
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,2008,55(7):1840-1848) proposed in 2008
Organism internal current source density is imaged using acoustoelectric effect principle, i.e. ultrasonic wave current source density imaging method
(Ultrasound Current Source Density Imaging, UCSDI), experiment prove UCSDI to arrhythmia cordis
Huge potential advantages in diagnosis be present.2013 Chinese patent (A of CN 103156605) also disclose that and a kind of imitated based on acoustic-electric
The biological tissue's Current density imaging answered.
Existing Ultrasonic Elasticity Imaging is simply assessed the mechanical attribute of biological tissue from mechanical characteristic, and one
As only consider elastic information；And existing acoustic-electric imaging is simply entered from the angle of electrology characteristic to the electrical characteristic parameter of biological tissue
Row is assessed, and rebuilds its distribution of conductivity.But the lesion much organized is often with the generation of a variety of phenomenons, and for not
With organizing these phenomenons to be not consistent, so only carrying out diagnosis to the single characteristic of pathological tissues from an angle has office
It is sex-limited.If two or more characterisitic parameter is assessed biological tissue simultaneously, it is possible to increase lesion tissue
Identification, improve the accuracy to biological tissue's lesion positioning.
The content of the invention
It is an object of the invention to provide a kind of more characteristic imaging sides of biological tissue based on acoustoelectric effect and acoustic radiation force
Method, using reciprocation between ultrasonic wave and tissue is focused on, ultrasonic elastograph imaging harmony Electrical imaging method is effectively combined
Come, realize the comprehensive assessment to lesion tissue from mechanical attribute and electrical point, to realize the mutual supplement with each other's advantages of two kinds of imaging methods,
More useful informations are provided for the detection and diagnosis of disease, so as to improve the identification of lesion tissue, are improved to biological group
Knit the accuracy of lesion positioning.To achieve the above object, the technical solution adopted by the present invention is as follows：
A kind of more characteristic imaging methods of biological tissue based on acoustoelectric effect and acoustic radiation force, used imaging system bag
Include control unit, ultrasonic transducer transmitting and sweep mechanism, electrical stimuli measurement module, ultrasonic transducer receiving circuit, data
Collection and six parts of processing unit and image reconstruction unit, the method includes the steps of：
(1) measurement focuses on the focal spot size in the focusing domain of ultrasonic transducer under ultrasonic perturbation mode, and determines to focus on ultrasound
Scanning sequency of the ripple to each focusing domain；
(2) launch low intensive trace pulse to ultrasonic transducer, in the case of focus ultrasonic is ignored, obtain boundary survey
Voltage vector φ and trace pulse echo-signal；
(3) when exciting current arrival crest or trough times caused by electrical stimuli measurement module, sent out to ultrasonic transducer
Penetrate the driving pulse of high intensity so that ultrasonic transducer is launched and sweep mechanism is operated in and focused under ultrasonic perturbation mode, focuses on
Ultrasonic n-th of focusing domain of wave disturbance, produces acoustic radiation force, and cause electrical conductivity that minor variations occur；
(4) while ultrasonic wave disturbance is focused on, measurement disturbance back boundary measurement voltage vector φn, and again to ultrasound
Transducer launches low intensive trace pulse, receives echo-signal；
(5) obtained boundary voltage signal psi and φ is measured respectively using step 2 and step 4nAnd pulse echo signal,
Obtain n-th focusing domain acoustoelectric signal and with corresponding displacement information；
(6) judge whether transducer completes the disturbance to all focusing domains, and obtain the corresponding border for focusing on domain position and survey
The variable quantity of value and with corresponding displacement variable, if complete, implementation steps 7；Focused on if it is not complete, then changing
The focusing domain position of ultrasonic wave disturbance, makes n=n+1, and jump to step 2；
(7) data processing is carried out to the data obtained, rebuilds biological tissue images.
It is of the invention compared with traditional Ultrasonic Elasticity Imaging, using focusing on influence of the ultrasonic wave to electrical characteristic parameter,
Increase the Electrical Characteristics of biological tissue on the basis of elastogram, the different qualities parameter of tissue is entered from different perspectives
Row comprehensive assessment, complementary information is provided for the Accurate Diagnosis of lesion tissue, so as to improve the accuracy rate of diagnosis.This method and system
Want to compare with traditional electricity chromatography imaging technique, using the positional information for focusing on ultrasonic wave, not only add the survey of boundary voltage
Information is measured, and adds the assessment from amechanical angle to biological tissue, makes up the deficiency of traditional medicine imaging means, improves electricity
Learn the resolution ratio of chromatography imaging technique.This method and system are using reciprocation between ultrasonic wave and tissue is focused on, by ultrasonic bullet
Property imaging harmony Electrical imaging method be effectively combined, realize and the synthesis of lesion tissue commented from mechanical attribute and electrical point
Estimate, the limitation assessed in the imaging method that breaks traditions from single characteristic angle lesion tissue.This method is by acoustic-electric image-forming principle
It is effectively combined with ultrasonic elastograph imaging principle, makes full use of complementarity of the different imaging methods to focus descriptive power,
More useful informations are provided for the detection and diagnosis of disease, it is more reliable, more accurate than relying on a kind of medical image merely so as to obtain
True focus category attribute information, it is expected to for doctor diagnose that reliable basis are provided while improve diagnosis and therapeutic process to survey essence
Degree and efficiency, a kind of thinking is provided for imaging in biological tissues method.
Brief description of the drawings
Fig. 1 is the system structure diagram of the present invention；
Fig. 2 is the current excitation of the present invention and the sequential relationship schematic diagram of pulse excitation
Fig. 3 is the operational flowchart of the present invention；
Fig. 4 is the ultrasonic elastograph imaging principle schematic of the present invention；
Fig. 5 is the acoustoelectric effect principle schematic of the present invention.
Embodiment
The more characteristics of the biological tissue based on acoustoelectric effect and acoustic radiation force of the present invention are imaged in conjunction with the accompanying drawings and embodiments
Method and system is illustrated.
The more characteristic imaging methods of the biological tissue based on acoustoelectric effect and acoustic radiation force and system of the present invention, utilizes focusing
The positional information that ultrasonic wave carries, while study during ultrasonic propagation the change of displacement of tissue caused by acoustic radiation force and super
Sound wave focuses on the change that tissue causes regional area electrical conductivity, analyzes the displacement information and acoustoelectric signal of acquisition, from mechanics angle
Degree and electrical point carry out comprehensive assessment to the elastic characteristic and electrology characteristic of tissue, and its reconstruction image reflects the power of tissue simultaneously
And electrology characteristic.
Biological tissue more characteristic imaging method and system of the present invention based on acoustoelectric effect and acoustic radiation force are mainly by six
Divide and form, as shown in Figure 1：(1) control system.The electrical stimuli part in control electric current source and the transmitting electricity of ultrasonic transducer
Road and receiving circuit.(2) ultrasonic transducer transmitting and sweep mechanism.The impulse waveform exported by signal generator, driving are super
Sonic transducer works, and the timing diagram of signal generator output waveform is as shown in Figure 2.Launch low intensive trace pulse first
Signal, the excitation pulse signal of Wave crest and wave trough moment transmitting high intensity is then reached in exciting current, finally launched again low strong
The trace pulse signal of degree.(3) electrical stimuli measurement module.M discrete electrodes are uniformly distributed on tested field domain border to pass
Sensor (or electrod-array), by applying current excitation on exciting electrode, realize the electrical stimuli to being tested field domain, measured object
Field forms a space sensitive field that tested object field can be scanned from different observation angles, to being tested object field under current excitation
Dielectric distribution produces modulating action, output boundary measured value.(4) ultrasonic transducer receiving circuit.Its task mainly receives
The echo-signal of trace pulse.(5) data acquisition and procession unit.Its task is quick acquisition module (3) and (4) in real time
The measurement data of the tested object field information of reflection of output, completes corresponding demodulation, amplification and filtering process, and the number that will be handled well
According to being output in computer PC.(6) image reconstruction unit.Its task is that the data reconstruction exported using unit (5) is tested object field
Two dimension or 3-D view, the reconstruction image reflect the mechanics and electrology characteristic of tissue simultaneously.Based on acoustoelectric effect and acoustic radiation
The more characteristic imaging methods of biological tissue of power and the operational flowchart of system are as shown in figure 3, can probably be divided into following step
Suddenly：
1st, the focal spot size in the focusing domain of focused transducer is measured, and determines to focus on ultrasonic wave to each focusing domain
Scanning sequency.
According to measurement object field and the size for the focal spot for focusing on domain, measurement object field is divided into N number of focusing domain, division principle
For：Focused transducer can complete the scanning to whole measurement object field, and it is not overlapping respectively to focus on domain.Record each focusing
The positional information in domain, and determine that focusing on ultrasonic wave intends to each scanning sequency for focusing on domain, from 1 to N.Can use from it is lower to
Upper, scanning sequency from left to right, but it is not limited to such a scan mode.
2nd, signal generator launches low intensive trace pulse to ultrasonic transducer, in the case of without focus ultrasonic, obtains
Boundary survey voltage vector φ and trace pulse echo-signal.
M discrete electrode sensors (or electrod-array) are uniformly distributed in measured object field border, by excitation electricity
Extremely upper to apply current excitation, exciting current uses frequency as 10kHz sine wave, realizes the electrical stimuli to being tested field domain, surveys
Boundary voltage signal corresponding to amount in measuring electrode.Adjacent current can be used to encourage, neighboring voltage measurement and exciting electrode
The excitation measurement pattern not measured, but it is not limited to such a pattern.Signal generator launches low intensive tracking to ultrasonic transducer
(pulse strength is less than 1W/cm for pulse2, centre frequency is the working frequency of ultrasonic transducer, is MHz levels, repetition rate and electric current
Driving frequency is consistent, is 10kHz, and the actuation duration is 0.3-1 μ s).In the case of the pulse excitation, ultrasonic wave is to focusing on tract tissue
Influence can be neglected, by applying current excitation or voltage drive on exciting electrode, realize the electricity to being tested field domain
Learn excitation, the boundary voltage signal corresponding to measurement in measuring electrode.Measure under cycle motivation circulation measurement on each electrode
Boundary voltage, form the boundary survey voltage vector φ in the case of being disturbed without ultrasound.Its mathematical modeling is
Wherein, Ω measures object field,Object field external boundary is measured, σ, u are respectively object field internal conductance rate, Potential Distributing, and n is side
Out-of-bounds normal vector, j are the outer normal direction current density of exciting electrode.
Ultrasonic transducer receives the echo-signal of trace pulse simultaneously, the initial position of target area is detected, as reference
Information.
3rd, when exciting current reaches the Wave crest and wave trough moment, signal generator launches the excitation arteries and veins of high intensity to ultrasonic transducer
Rush (pulse strength 10-4000W/cm2, centre frequency is the working frequency of ultrasonic transducer, is MHz levels, repetition rate and electricity
It is consistent to flow driving frequency, is 10kHz, the actuation duration is longer than the time of trace pulse, is 45-75 μ s), focus on ultrasonic wave disturbance
N-th of focusing domain, produces acoustic radiation force, and cause electrical conductivity that minor variations occur.
Focused transducer is perpendicular to the two-dimensional imaging section of measurement object field, when exciting current reaches Wave crest and wave trough
Carve, signal generator launches the driving pulse of high intensity to ultrasonic transducer, focuses on ultrasonic n-th of focusing domain of wave disturbance, 1≤n
≤N.Because energy density difference caused by absorption or reflection to focus on ultrasonic wave generation sound in the communication process of tissue
Radiant force, when ultrasonic wave is plane wave, caused radiant force size is in its communication process
The size of wherein F radiant forces for caused by, WabsorbedFor the absorbed power of medium during ultrasonic propagation, c is
The speed that ultrasonic wave is propagated in media as well, α are the absorption coefficient of medium, and I is the mean intensity of ultrasonic wave unit area.
On the one hand acoustic radiation force can cause axial compression stretching, displacement is produced in the axial direction, to forward pass in a manner of compressional wave
Broadcast；On the other hand adjacent tissue is acted on by shear stress, produce the shearing wave laterally propagated, show as horizontal each point edge
Axially chronological shear displacemant, as shown in Figure 4.
Simultaneously because acoustic pressure periodically vibrations cause local organization electrical conductivity that minor variations occur, i.e. acoustoelectric effect is former
Reason, as shown in Figure 5.Therefore focusing on ultrasonic wave makes n-th of region electrical conductivity produce disturbance, and meets δ σ=kP σ.Wherein, δ
σ is focuses on conductivity variations amount caused by ul-trasonic irradiation, and σ is medium initial conductivity distribution in object field, and P is focus point sound
Pressure, the acoustoelectric effect coefficient of k media.
4th, while ultrasonic wave disturbance is focused on, measurement disturbance back boundary measurement voltage vector φn, and changed again to ultrasound
Energy device launches low intensive trace pulse, and (pulse strength is less than 1W/cm2, centre frequency is the working frequency of ultrasonic transducer, is
MHz levels, repetition rate is consistent with current excitation frequency, is 10kHz, and the actuation duration is 0.3-1 μ s), receives echo-signal.
While n-th of focusing domain of focusing ultrasonic wave disturbance is focused on, the excitation for completing electrod-array in step 2 again is surveyed
Amount process, obtain the boundary survey voltage vector φ that object field is measured when focusing on ultrasonic wave disturbance focusing domainn, its mathematical modeling
For：
Wherein, σn=σ+δ σ are to focus on ultrasonic n-th of distribution of conductivity focused on behind domain of wave disturbance, unTo focus on ultrasonic wave
Disturb n-th of Potential Distributing focused on behind domain of object field.
Launch trace pulse, receives echo-signal, the position after the disturbance of detection target area to ultrasonic transducer again.
5th, obtained boundary voltage signal psi and φ is measured respectively using step 2 and step 4nAnd pulse echo signal,
Obtain the acoustoelectric signal in n-th focusing domain and corresponding displacement information.
Boundary voltage signal psi and φnIn simultaneously contain low-frequency voltage signal and high-frequency voltage signal, filtered by high pass
Ripple obtains acoustoelectric signal, reflects the electrology characteristic of tissue.By the echo-signal obtained twice, focusing ultrasonic wave can be obtained and disturbed
Displacement variable after dynamic, and then the elastic characteristic of tissue is assessed, but it is not limited to such a mode.Because acoustic radiation force can make group
The change being subjected to displacement on longitudinal direction is knitted, and produces shearing wave in the horizontal, so can also be by measuring shear wave velocity and cutting
Cut the elastic characteristic that the parameters such as the phase velocity of ripple assess tissue.
6th, judge whether transducer completes the disturbance to all focusing domains, and obtain the corresponding acoustoelectric signal for focusing on domain position
With with corresponding displacement variable.If complete, implementation steps 7；Ultrasonic wave disturbance is focused on if it is not complete, then changing
Domain position is focused on, makes n=n+1, and jump to step 2.
7th, data processing is carried out to the data obtained, rebuilds biological tissue images.
Based on acoustoelectric effect principle and ultrasonic elastograph imaging principle, line number is entered to the acoustoelectric signal and displacement information obtained
According to processing, tested object field distribution of conductivity image harmony radiation force pulses distributed image is rebuild respectively.With reference to each poly- in step 1
The positional information of focal regions, two groups of reconstruction images are merged, obtain electrical conductivity and acoustic radiation force fused images, the reconstructed results
The electricity and mechanics parameters information of biological tissue are contained simultaneously.
The more characteristic imaging methods of the biological tissue based on acoustoelectric effect and acoustic radiation force and system of the present invention, it mainly should
For imaging in biological tissues, but it can also be applied to produce other measured mediums of acoustoelectric effect and acoustic radiation force.
The present embodiment is special to the elasticity of tissue from amechanical angle and electrical point based on acoustic radiation force and acoustoelectric effect principle
Property and conductivity characteristic carry out comprehensive assessment, using focusing on reciprocation between ultrasonic wave and tissue, by ultrasonic elastograph imaging and
Acoustic-electric imaging method is effectively combined, and is realized the comprehensive assessment to lesion tissue from mechanical attribute and electrical point, is broken
The limitation diagnosed in conventional imaging method from the angle of single characteristic to lesion tissue.By acoustic-electric image-forming principle and Ultrasonic elasticity into
As principle is effectively combined, two kinds of imaging methods have complementary advantages, and detection for disease and diagnose and provide more useful informations,
So as to reach the identification for improving lesion tissue, the purpose of the accuracy to biological tissue's lesion positioning is improved, is biological tissue
Imaging method provides a kind of thinking.
Claims (1)
1. a kind of more characteristic imaging methods of biological tissue based on acoustoelectric effect and acoustic radiation force, used imaging system include
Control unit, ultrasonic transducer transmitting and sweep mechanism, electrical stimuli measurement module, ultrasonic transducer receiving circuit, data are adopted
Collection and six parts of processing unit and image reconstruction unit.The method includes the steps of：
(1) measurement focuses on the focal spot size in the focusing domain of ultrasonic transducer under ultrasonic perturbation mode, and determines to focus on ultrasonic wave pair
Each scanning sequency for focusing on domain；
(2) launch low intensive trace pulse to ultrasonic transducer, in the case of focus ultrasonic is ignored, obtain boundary survey voltage
Vectorial φ and trace pulse echo-signal；
(3) when exciting current arrival crest or trough times caused by electrical stimuli measurement module, launch to ultrasonic transducer high
The driving pulse of intensity so that ultrasonic transducer is launched and sweep mechanism is operated in and focused under ultrasonic perturbation mode, focuses on ultrasound
N-th of focusing domain of wave disturbance, produces acoustic radiation force, and cause electrical conductivity that minor variations occur；
(4) while ultrasonic wave disturbance is focused on, measurement disturbance back boundary measurement voltage vector φn, and again to ultrasonic transducer
Launch low intensive trace pulse, receives echo-signal；
(5) obtained boundary voltage signal psi and φ is measured respectively using step 2 and step 4nAnd pulse echo signal, obtain
N-th focusing domain acoustoelectric signal and with corresponding displacement information；
(6) judge whether transducer completes the disturbance to all focusing domains, and obtain the corresponding boundary survey value for focusing on domain position
Variable quantity and with corresponding displacement variable, if complete, implementation steps 7；Ultrasound is focused on if it is not complete, then changing
The focusing domain position of wave disturbance, makes n=n+1, and jump to step 2；
(7) data processing is carried out to the data obtained, rebuilds biological tissue images.
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