CN107497039B - Medical oncology device of dosing - Google Patents

Medical oncology device of dosing Download PDF

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Publication number
CN107497039B
CN107497039B CN201710967857.4A CN201710967857A CN107497039B CN 107497039 B CN107497039 B CN 107497039B CN 201710967857 A CN201710967857 A CN 201710967857A CN 107497039 B CN107497039 B CN 107497039B
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positioning
storage bag
fixedly connected
medicine storage
medicine
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CN107497039A (en
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周明慧
陈晓莉
吴彦萍
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First Affiliated Hospital of Henan University of Science and Technology
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First Affiliated Hospital of Henan University of Science and Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/12—Blood circulatory system

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention discloses a drug delivery device for medical oncology, and relates to the technical field of drug delivery for medical oncology. It comprises a fiber tube, a slow release device and bracket positioning devices at the left end and the right end of the fiber tube; ferroferric oxide is filled in the fiber tube; the bracket positioning device comprises a positioning shell fixedly connected with the end part of the fiber tube; a magnetostrictive block is arranged in the positioning shell; the upper end and the lower end of the magnetostrictive block are respectively fixedly connected with the supporting rods on the upper side and the lower side; the outer end of the supporting rod is fixedly connected with an arc-shaped positioning supporting net; the slow release device comprises a medicine storage bag fixedly connected with the side edge of the positioning shell on the left side; the side of the medicine storage bag is communicated with a medicine injection pipe; the drug injection pipe is fixedly connected with the positioning support net above the left side; the right end of the medicine storage bag is opened and is hermetically connected with a slow release membrane; the medicine storage bag is filled with anti-tumor magnetic nano-particle medicines. The invention has the beneficial effects that: through the adsorption of built-in magnetic field, improve treatment, the patient is more free, and the endovascular location is controllable, and is more practical.

Description

Medical oncology device of dosing
Technical Field
The invention relates to the technical field of drug administration in medical oncology.
Background
The targeted drug delivery can selectively deliver the drug to a target site, so that the concentration of the drug on a focus is improved, and the accumulation of the drug in normal tissue cells is reduced, thereby being one of the most effective methods for reducing the toxicity of the drug and improving the curative effect. In the growth stage of tumors, the tumors are generally attached to blood vessels such as arteries and the like, and are connected with blood supply vessels of a human body through self-growing blood vessels to supply the growth of the tumors. The active region of the anti-tumor magnetic nanoparticle medicine is controlled by the external magnetic field, so that the medicine concentration in the treatment region can be effectively improved, but the control is carried out by external magnetic field equipment for a long time, the regulation and control are complex, and the freedom of a patient is limited during the treatment period.
Disclosure of Invention
The invention aims to solve the technical problem and provides a drug delivery device for medical oncology aiming at the technical defects. Through the adsorption of built-in magnetic field, improve treatment, the patient is more free, and the endovascular location is controllable, and is more practical.
The technical scheme adopted by the invention is as follows: provides a drug delivery device for medical oncology, which comprises a fiber tube, a slow release device and bracket positioning devices at the left end and the right end of the fiber tube; ferroferric oxide is filled in the fiber tube; the bracket positioning device comprises a positioning shell fixedly connected with the end part of the fiber tube; a magnetostrictive block is arranged in the positioning shell; the upper end and the lower end of the positioning shell are both provided with guide holes; each guide hole is internally and slidably connected with a support rod; the upper end and the lower end of the magnetostrictive block are respectively fixedly connected with the supporting rods on the upper side and the lower side; the outer end of the supporting rod is fixedly connected with an arc-shaped positioning supporting net; the support positioning devices on the left side and the right side have the same structure; the slow release device comprises a medicine storage bag fixedly connected with the side edge of the positioning shell on the left side; the side of the medicine storage bag is communicated with a medicine injection pipe; rubber sealing the end of the injection tube; the drug injection pipe is fixedly connected with the positioning support net above the left side; the right end of the medicine storage bag is opened and is hermetically connected with a slow release membrane; the medicine storage bag is filled with anti-tumor magnetic nano-particle medicines.
Further optimizing the technical scheme, the fixed lines are uniformly arranged in the medicine storage bag of the medical oncology medicine feeding device; the upper end and the lower end of the fixed line are respectively fixedly connected with the upper end and the lower end of the inner side of the medicine storage bag.
Further optimize this technical scheme, sliding connection has the magnetic ring on oncology's the fibre pipe of device of dosing.
Further optimize this technical scheme, medical oncology device of dosing's medicine storage bag is the elasticity bag.
The invention has the beneficial effects that:
1. the anti-tumor magnetic nanoparticle medicine is a tumor treatment inhibitor, and the magnetic ferroferric oxide is embedded in a blood vessel to adsorb the anti-tumor magnetic nanoparticle medicine, so that the concentration of the inhibitor in the blood vessel of a tumor growth area is kept at a higher level, the flowing of the inhibitor is reduced, a magnetic field generation control device is not required to be arranged outside the body for a long time, the magnetic adsorption is directly carried out in the blood vessel, the adsorption effect is better, the problem of the depth of the blood vessel is not required to be considered, and a patient is more free;
the stent positioning device can control positioning by the magnetostrictive block, after the stent positioning device is placed in a blood vessel, the stretching of the magnetostrictive block can be controlled by an external magnetic field, when the magnetostrictive block is shortened by the external magnetic field, the support rod moves to the axis, the positioning support net loses the internal positioning function, the position of the fiber tube can be adjusted under the external magnetic attraction function, so that other parts of the blood vessel can be treated, the magnetostrictive block is controlled by the magnetic field to extend to the original length, and the support rod moves outwards to drive the positioning support net and the inner wall of the blood vessel to support and position;
the slow release device can prolong the action time of the medicine after one-time injection, the medicine in the medicine storage bag can be slowly released to the outside under the control of the slow release film, so that the concentration reduction speed of the inhibitor adsorbed on the outer side of the fiber tube is slowed, the medicine injection port of the medicine storage bag is fixedly connected with the positioning support net, the position of the medicine injection port is fixed, the medicine supplement during later injection is facilitated, and the medicine storage bag does not need to be taken out;
2. the shape of the medicine storage bag can be limited by arranging the fixed line in the medicine storage bag, and the influence on blood flow caused by over-large radial expansion of the medicine storage bag is avoided;
3. the magnetic conduction rings can improve the adsorption area and the adsorption range, adsorb more medicines, increase the medicine concentration in the range, facilitate the adjustment of the distribution of the internal medicine concentration according to the actual situation, improve the treatment effect, and can be adjusted in position by the suction force of the external magnetic field in a sliding way on the fiber tube.
Drawings
FIG. 1 is a schematic plan view of the present invention;
FIG. 2 is a schematic view of the A-A view in FIG. 1;
in the figure, 1, a fiber tube; 2. a positioning shell; 3. a magnetostrictive block; 4. a guide hole; 5. a strut; 6. positioning the support net; 7. a medicine storage bag; 8. a medicine injection tube; 9. a slow release film; 10. shaping a line; 11. a magnetic conductive ring; 12. tumor vessels are indicated.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.
As shown in fig. 1-2, the drug delivery device for medical oncology comprises a fiber tube 1, a slow release device, and stent positioning devices at the left and right ends of the fiber tube 1; ferroferric oxide is filled in the fiber tube 1; the bracket positioning device comprises a positioning shell 2 fixedly connected with the end part of the fiber tube 1; a magnetostrictive block 3 is arranged in the positioning shell 2; the upper end and the lower end of the positioning shell 2 are both provided with guide holes 4; a support rod 5 is connected in each guide hole 4 in a sliding manner; the upper end and the lower end of the magnetostrictive block 3 are respectively fixedly connected with the supporting rods 5 at the upper side and the lower side; the outer end of the supporting rod 5 is fixedly connected with an arc-shaped positioning supporting net 6; the support positioning devices on the left side and the right side have the same structure; the slow release device comprises a medicine storage bag 7 fixedly connected with the side edge of the left positioning shell 2; the side of the medicine storage bag 7 is communicated with a medicine injection tube 8; rubber sealing of 8 ports of the medicine injection pipe; the medicine injection pipe 8 is fixedly connected with the positioning support net 6 above the left side; the right end of the medicine storage bag 7 is opened and is hermetically connected with a slow release membrane 9; the medicine storage bag 7 is filled with anti-tumor magnetic nano particle medicines; the fixed lines 10 are uniformly arranged in the medicine storage bag 7; the upper end and the lower end of the fixed line 10 are respectively fixedly connected with the upper end and the lower end of the inner side of the medicine storage bag 7; the fiber tube 1 is connected with a magnetic conduction ring 11 in a sliding way; the medicine storage bag 7 is an elastic bag.
When the invention is used, arterial blood vessels and the like can be displayed by means of the existing angiography, and the like, the invention is placed into the blood vessels by using an external magnetic field device through vascular surgery, the magnetostrictive blocks 3 are shortened by using the action of the external magnetic field, the stent positioning device at one end is guided to move in the blood vessels by using magnetic attraction, finally, the stent positioning device completely enters the interior of the blood vessels, the external magnetic field is removed after positioning, the magnetostrictive blocks 3 are recovered, the support positioning in the interior of the blood vessels is realized, the growth area of tumors is positioned between the stent positioning devices at two sides, then, the anti-tumor magnetic nano particle medicine is injected into a treatment section through an injector, and under the magnetic adsorption action of ferroferric oxide in the fiber tube 1, the medicine maintains the treatment action for a long. The medicine in the medicine storage bag 7 is slowly released to the treatment area, and the medicine is continuously supplemented, so that the medicine can be maintained for a longer time. When the medicine is injected next time, the port of the medicine injection tube 8 of the medicine storage bag 7 is displayed by using an influence observation technology, the medicine inside the medicine storage bag 7 is supplemented by using the puncture of the injector, and then a certain amount of medicine is injected into the treatment area. The medicine storage bag 7 can obviously prolong the action time of the medicine, improve the action effect and prolong the injection period.
After the tumor is treated, or the tumor growth section moves, the external magnetic field device can be used for moving the stent in the blood vessel, the display observation is carried out by the aid of a blood vessel imaging technology, the external magnetic field controls the magnetostrictive block 3 to shorten, the stent positioning device loses the supporting and positioning with the inner wall of the blood vessel, then the stent positioning device is guided to move to the growth connection area of the tumor and the blood vessel by magnetic attraction, the positioning is finished, the magnetic field is removed, the drug injection treatment is continued, and the blood vessel operation is not required to be carried out for multiple times.
After the internal positioning is completed by the bracket positioning device, the external magnetic field device can be utilized, the magnetic attraction guides the movement of the magnetic conduction ring 11, the position of the magnetic conduction ring is controlled, and the magnetic conduction device is used for enabling the region with more tumor blood vessels to be connected to maintain more medicine to stay and enhancing the treatment effect.

Claims (4)

1. An oncology department device of dosing which characterized in that: comprises a fiber tube (1), a slow release device and a bracket positioning device at the left end and the right end of the fiber tube (1); ferroferric oxide is filled in the fiber tube (1); the bracket positioning device comprises a positioning shell (2) fixedly connected with the end part of the fiber tube (1); a magnetostrictive block (3) is arranged in the positioning shell (2); the upper end and the lower end of the positioning shell (2) are both provided with guide holes (4); a support rod (5) is connected in each guide hole (4) in a sliding manner; the upper end and the lower end of the magnetostrictive block (3) are respectively fixedly connected with the supporting rods (5) on the upper side and the lower side; the outer end of the supporting rod (5) is fixedly connected with an arc-shaped positioning supporting net (6); the support positioning devices on the left side and the right side have the same structure;
the slow release device comprises a medicine storage bag (7) fixedly connected with the side edge of the left positioning shell (2); the side of the medicine storage bag (7) is communicated with a medicine injection pipe (8); the end of the medicine injection tube (8) is sealed by rubber; the medicine injection pipe (8) is fixedly connected with the positioning support net (6) above the left side; the right end of the medicine storage bag (7) is opened and is hermetically connected with a slow release film (9); the medicine storage bag (7) is filled with anti-tumor magnetic nano-particle medicines.
2. The medical oncology drug delivery device of claim 1, wherein: the fixed lines (10) are uniformly arranged in the medicine storage bag (7); the upper end and the lower end of the fixed line (10) are respectively fixedly connected with the upper end and the lower end of the inner side of the medicine storage bag (7).
3. The medical oncology drug delivery device of claim 1, wherein: the fiber tube (1) is connected with a magnetic conduction ring (11) in a sliding way.
4. The medical oncology drug delivery device of claim 1, wherein: the medicine storage bag (7) is an elastic bag.
CN201710967857.4A 2017-10-18 2017-10-18 Medical oncology device of dosing Active CN107497039B (en)

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Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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CN107497039B true CN107497039B (en) 2020-04-17

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Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1078912A (en) * 1992-05-18 1993-12-01 王庆书 Internal positioner for medical medicine
CN1506120A (en) * 2002-12-11 2004-06-23 中国科学院电工研究所 Medicine locating method for magnetic medicine target treatment
CN1539523A (en) * 2003-10-30 2004-10-27 武汉理工大学 Medical metal bracket capable of absorbing magnetic capsule of drug
CN1897867A (en) * 2003-12-25 2007-01-17 奥林巴斯株式会社 Medical capsule apparatus
CN101264327A (en) * 2008-04-25 2008-09-17 北京中孵友信医药科技有限公司 Magnetic target carrier system
CN101282677A (en) * 2005-10-05 2008-10-08 奥林巴斯医疗株式会社 Capsule type medical device, its guidance system and guidance method and examinee insertion device
WO2009079388A2 (en) * 2007-12-14 2009-06-25 Oregon Health & Science University Drug delivery cuff
WO2010142284A2 (en) * 2009-06-11 2010-12-16 Andrae Wilfried Arrangement for the remote-controlled release of active substances
CN101938950A (en) * 2008-03-19 2011-01-05 阿尔托大学基金会 Internal osteodistraction device
CN103816578A (en) * 2014-03-05 2014-05-28 广州一代医药科技有限公司 Targeted drug delivery device for anti-tumor magnetic nanometer particle drug
CN203989504U (en) * 2014-04-10 2014-12-10 深圳普门科技有限公司 There is capsule photon therapy device, the system of guide function
CN205494651U (en) * 2016-02-04 2016-08-24 晏党 Novel medical oncology doses device
CN206138577U (en) * 2016-06-29 2017-05-03 宋凯 Targetable drug delivery device of antitumor nano particles medicine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101619931B1 (en) * 2014-06-10 2016-05-13 재단법인대구경북과학기술원 A Capsule type microrobot and method of use
NZ743053A (en) * 2015-11-30 2022-10-28 Jvd Inc Medicine delivery and animal management systems

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1078912A (en) * 1992-05-18 1993-12-01 王庆书 Internal positioner for medical medicine
CN1506120A (en) * 2002-12-11 2004-06-23 中国科学院电工研究所 Medicine locating method for magnetic medicine target treatment
CN1539523A (en) * 2003-10-30 2004-10-27 武汉理工大学 Medical metal bracket capable of absorbing magnetic capsule of drug
CN1897867A (en) * 2003-12-25 2007-01-17 奥林巴斯株式会社 Medical capsule apparatus
CN101282677A (en) * 2005-10-05 2008-10-08 奥林巴斯医疗株式会社 Capsule type medical device, its guidance system and guidance method and examinee insertion device
WO2009079388A2 (en) * 2007-12-14 2009-06-25 Oregon Health & Science University Drug delivery cuff
CN101938950A (en) * 2008-03-19 2011-01-05 阿尔托大学基金会 Internal osteodistraction device
CN101264327A (en) * 2008-04-25 2008-09-17 北京中孵友信医药科技有限公司 Magnetic target carrier system
WO2010142284A2 (en) * 2009-06-11 2010-12-16 Andrae Wilfried Arrangement for the remote-controlled release of active substances
CN103816578A (en) * 2014-03-05 2014-05-28 广州一代医药科技有限公司 Targeted drug delivery device for anti-tumor magnetic nanometer particle drug
CN203989504U (en) * 2014-04-10 2014-12-10 深圳普门科技有限公司 There is capsule photon therapy device, the system of guide function
CN205494651U (en) * 2016-02-04 2016-08-24 晏党 Novel medical oncology doses device
CN206138577U (en) * 2016-06-29 2017-05-03 宋凯 Targetable drug delivery device of antitumor nano particles medicine

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