CN107391964A - A kind of gene sequence data management method being combined with clinical information - Google Patents
A kind of gene sequence data management method being combined with clinical information Download PDFInfo
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- CN107391964A CN107391964A CN201710607551.8A CN201710607551A CN107391964A CN 107391964 A CN107391964 A CN 107391964A CN 201710607551 A CN201710607551 A CN 201710607551A CN 107391964 A CN107391964 A CN 107391964A
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- gene sequence
- sequence data
- patient
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B99/00—Subject matter not provided for in other groups of this subclass
Abstract
The present invention relates to a kind of gene sequence data management method being combined with clinical information, comprise the following steps：Newly-built corresponding patient's account in patient management module, and fill in its essential information；Patient's account corresponding to the gene sequence data that will be uploaded first is set in sample management module, then sets the health status of patient corresponding to the gene sequence data；By gene sequence data filing management；Patient's account and gene sequence data are set into label and remarks.The gene sequence data management method provided by the invention being combined with clinical information, data are managed centered on " patient " or bion, gene sequence data is combined with clinical information, solves gene sequence data " isolated island " problem, meet doctor and scientific research personnel carries out the demand of biomedical research, to the information needed they provided outside more gene sequence datas, the needs of practical application can be met well.
Description
Technical field
The invention belongs to gene sequence data administrative skill field, and in particular to a kind of gene being combined with clinical information
Sequence data management method.
Background technology
Ripe and perfect with two generation sequencing technologies, gene order-checking is widely applied in tumor research field.
Tumor sample gene order-checking can be divided into full-length genome and resurvey sequence, sequencing of extron group and target area capture sequencing.Full genome
It is to carry out full-length genome to mankind's Different Individual or colony to survey again that group, which resurveys sequence (Whole Genome Sequencing, WGS),
Sequence, by compared with original gene, obtaining abundant full-length genome variation information, and carried out on individual or population level
Analysis of biological information.Full sequencing of extron group (Whole Exome Sequencing, WES) utilizes probe hybridization enrichment extron
The DNA sequence dna in region, with reference to high-flux sequence, it can be found that exon region correlation variation information.Target area capture sequencing
It is the probe by customizing genome target region, is hybridized with genomic DNA, is carried out after target area domain dna is enriched with high
The technological means of flux sequencing.Target area sequencing carries out high depth sequencing for target gene, can accurately detect variation, generally
Genome sequencing and extron sequencing is coordinated to carry out the checking of large sample size to having obtained gene mutation.
In existing technology, for the management of the gene sequence data progress obtained after the completion of sequencing, two are roughly divided into
Kind, a kind of is data-centered way to manage, i.e., grouping management is carried out by file to data, such as BMKCloud companies
Genetic analysis platform；Another kind is the way to manage centered on engineering project, i.e., carries out pipe to data centered on engineering
Reason, as in Chinese patent " the automated analysis method and system of CN104484581A biological information projects " to gene sequence data
Way to manage be to carry out tissue centered on project.Whether data-centered way to manage, or centered on project
Way to manage, be all only that gene sequence data is managed in itself, and have ignored the background of gene sequence data behind
Information.That is, these way to manages cause gene sequence data to become isolated " data ", gene sequence is generated
Column data " isolated island " problem；Such way to manage for some user groups can not meet demand, such as, Yi Shengyao
Understand the clinical distribution meaning of certain gene, scientific research personnel will check Sex distribution and the time distribution of certain gene order.It is existing
Have in technology, using gene sequence data as hard core control data, patient information is intended only as its attribute, then, it is same
The gene sequence data of individual patient will have substantial amounts of duplicate message, waste the space of system, and reduce system performs effect
Rate.There is significant limitation for the data management mode of prior art.
The content of the invention
For above-mentioned problems of the prior art, it is an object of the invention to provide one kind can avoid the occurrence of above-mentioned skill
The gene sequence data management method being combined with clinical information of art defect.
In order to realize foregoing invention purpose, technical scheme provided by the invention is as follows：
A kind of gene sequence data management method being combined with clinical information, is by gene sequence data management system
Come what is realized, the gene sequence data management system include patient management module, sample management module, tag control module,
Search module.
Further, the gene sequence data management method comprises the following steps：
Step 1：Newly-built corresponding patient's account in patient management module, and fill in its essential information；
Step 2：Patient's account corresponding to the gene sequence data that will be uploaded first is set in sample management module,
The health status of patient corresponding to the gene sequence data is set again；
Step 3：By gene sequence data filing management；
Step 4：Patient's account and gene sequence data are set into label and remarks.
Further, patient management module manages all patient's account and its essential information, includes institute in clinical information
Some essential informations and medical record information.
Further, unique sample that the information that sample management module includes includes the generation of each gene sequence data is compiled
Number, sample type, sequencing type, corresponding patient, the corresponding diagnostic result of gene sequence data.
Further, tag control module is used to manage the label being easy to gene sequence data and patient's packet.
Further, the function that search module provides includes search patient account, gene sequence data essential information, mark
Label.
The gene sequence data management method provided by the invention being combined with clinical information, with " patient " or bion
Centered on manage data, gene sequence data be combined with clinical information, solve gene sequence data " isolated island " problem,
The demand that doctor and scientific research personnel carry out biomedical research is met, to they providing outside more gene sequence datas
Information needed, the thought of Similar integral is harmonious in the management thought and programming language centered on " patient ", i.e., " patient " is base
Because of the parent of sequence data, gene sequence data is the subclass of " patient ", can effectively reduce information redundancy and repetition, be more convenient for
Management and application, the needs of practical application can be met well.
Brief description of the drawings
Fig. 1 is the structured flowchart of the gene sequence data management system of the present invention；
Fig. 2 is the flow chart of the gene sequence data management method of the present invention.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, below in conjunction with the accompanying drawings and specific implementation
The present invention will be further described for example.It should be appreciated that specific embodiment described herein is only to explain the present invention, and do not have to
It is of the invention in limiting.Based on the embodiment in the present invention, those of ordinary skill in the art are not making creative work premise
Lower obtained every other embodiment, belongs to the scope of protection of the invention.
A kind of gene sequence data management method being combined with clinical information, is by gene sequence data management system
Come what is realized；As shown in figure 1, the gene sequence data management system includes patient management module, sample management module, label
Management module, search module.Wherein：
Patient management module manages all patient's account and its essential information, includes basic letter all in clinical information
Breath and medical record information, the specially information such as name, sex, date of birth, familial inheritance medical history, remarks；What this module can be realized
Function has newly-increased patient's account, editor patient's account, deletes patient's account；
The information that sample management module includes includes unique sample number of each gene sequence data generation, gene order
The sample type of data, type, corresponding patient, corresponding diagnostic result etc. is sequenced, the function that can be realized has newly-increased sample, volume
Collect sample, check sample；
Tag control module is used to manage the label being easy to gene sequence data and patient's packet；
Search module provides the functions such as search patient account, gene sequence data essential information, label.
As shown in Fig. 2 a kind of gene sequence data management method being combined with clinical information, comprises the following steps：
Step 1：Newly-built corresponding patient's account in patient management module, and its essential information, such as name are filled in, property
Not, date of birth, familial inheritance medical history, remarks etc..
Step 2：Patient's account corresponding to the gene sequence data that will be uploaded first is set in sample management module
(if can not find patient's account, return to step one creates new patient's account), then would set the gene sequence data pair
The health information of the patient answered；Because the health status of patient is not unalterable, therefore same person is different strong
Gene sequence data corresponding to health situation may also be different, such as, the patient causes health status to change there occurs gene mutation
Become.
Step 3：By gene sequence data filing management.
Step 4：Patient's account and gene sequence data are set into label and remarks, are easy to grouping management.
The advantageous effects of the present invention include：
It is that core is managed to data with " patient ", coordinates search and label function is set, can efficiently manage number
According to logic is reasonable, and it is convenient to search, and easily can also quickly find what oneself was wanted even if the very more user of data bulk
Data；
, can the basic document to " people " and the health in hospital diagnosis simultaneously using " patient " as the unit of data management
The reasonable storage and management of condition information without any confusion, facilitate user carry out data source retrospect, analysis result checking and do into
The analysis of one step uses；
Using " patient " as the unit of data management, " patient " is the redundancy letter that can effectively reduce data management system
Breath, patient realize one-to-many corresponding relation with gene sequence data, and patient information is no longer one of gene sequence data
Attribute, but its parent, improve data management efficiency and search speed, simplify system complexity.
The gene sequence data management method provided by the invention being combined with clinical information, with " patient " or bion
Centered on manage data, gene sequence data be combined with clinical information, solve gene sequence data " isolated island " problem,
The demand that doctor and scientific research personnel carry out biomedical research is met, to they providing outside more gene sequence datas
Information needed, the thought of Similar integral is harmonious in the management thought and programming language centered on " patient ", i.e., " patient " is base
Because of the parent of sequence data, gene sequence data is the subclass of " patient ", can effectively reduce information redundancy and repetition, be more convenient for
Management and application, the needs of practical application can be met well.
Embodiment described above only expresses embodiments of the present invention, and its description is more specific and detailed, but can not
Therefore it is interpreted as the limitation to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art,
Without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection model of the present invention
Enclose.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (6)
1. a kind of gene sequence data management method being combined with clinical information, it is characterised in that be by gene order number
According to management system come what is realized, the gene sequence data management system includes patient management module, sample management module, label
Management module, search module.
2. the data managing method according to claim 1 being combined with clinical information, it is characterised in that the gene sequence
Column data management method comprises the following steps：
Step 1：Newly-built corresponding patient's account in patient management module, and fill in its essential information；
Step 2：Patient's account corresponding to the gene sequence data that will be uploaded first is set in sample management module, then is set
The health status of patient corresponding to the gene sequence data is put；
Step 3：By gene sequence data filing management；
Step 4：Patient's account and gene sequence data are set into label and remarks.
3. the gene sequence data management method being combined with clinical information according to claim 1-2, it is characterised in that
Patient management module manages all patient's account and its essential information, includes essential information and case history all in clinical information
Information.
4. the gene sequence data management method being combined with clinical information according to claim 1-2, it is characterised in that
The information that sample management module includes includes unique sample number of each gene sequence data generation, the sample of gene sequence data
This type, sequencing type, corresponding patient, corresponding diagnostic result.
5. the gene sequence data management method being combined with clinical information according to claim 1-4, it is characterised in that
Tag control module is used to manage the label being easy to gene sequence data and patient's packet.
6. the gene sequence data management method being combined with clinical information according to claim 1-5, it is characterised in that
The function that search module provides includes search patient account, gene sequence data essential information, label.
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| CN201710607551.8A CN107391964A (en) | 2017-07-24 | 2017-07-24 | A kind of gene sequence data management method being combined with clinical information |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1547721A (en) * | 2001-08-28 | 2004-11-17 | System, method, and apparatus for storing, retrieving, and integrating clinical, diagnostic, genomic, and therapeutic data | |
| CN101350039A (en) * | 2008-04-29 | 2009-01-21 | 山东省胸科医院 | Information management system of tuberculosis monitoring early warning network |
| US20100169107A1 (en) * | 2008-12-30 | 2010-07-01 | Samsung Electronics Co., Ltd. | Method and apparatus for integrated personal genome management |
-
2017
- 2017-07-24 CN CN201710607551.8A patent/CN107391964A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1547721A (en) * | 2001-08-28 | 2004-11-17 | System, method, and apparatus for storing, retrieving, and integrating clinical, diagnostic, genomic, and therapeutic data | |
| CN101350039A (en) * | 2008-04-29 | 2009-01-21 | 山东省胸科医院 | Information management system of tuberculosis monitoring early warning network |
| US20100169107A1 (en) * | 2008-12-30 | 2010-07-01 | Samsung Electronics Co., Ltd. | Method and apparatus for integrated personal genome management |
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| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 225000 Development West Road 217, Yangzhou High-tech Industrial Development Zone, Jiangsu Province Applicant after: Jiangsu Medical Union Biotechnology Co., Ltd. Address before: 225000 217 Development West Road, Yangzhou high tech Industrial Development Zone, Jiangsu Applicant before: Yangzhou Medical Union Biological Technology Co., Ltd. |
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Application publication date: 20171124 |