CN107328949B - A kind of method and device for realizing the more parts of spontaneous sequential flowings of liquid - Google Patents
A kind of method and device for realizing the more parts of spontaneous sequential flowings of liquid Download PDFInfo
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- CN107328949B CN107328949B CN201710500139.6A CN201710500139A CN107328949B CN 107328949 B CN107328949 B CN 107328949B CN 201710500139 A CN201710500139 A CN 201710500139A CN 107328949 B CN107328949 B CN 107328949B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1044—Using pneumatic means
Abstract
The present invention provides a kind of method and devices for realizing the more parts of spontaneous sequential flowings of liquid, the characteristics of this method, is, inflating pressure in the system formed first to closed container (3) and connecting tube (4), the internal pressure of system is set to be greater than external pressure, then the gas of a part of High Voltage is stopped respectively by the closure of liquid, finally by the turned on outside for converging connection end and system of connecting tube (4), make to form pressure difference between closed container (3) and connecting tube (4), then liquid neous flow under the action of high pressure gas, and when different due to closed container (3) volume, the runner volume of connecting tube (4) is equal, or each closed container (3) volume it is all the same when, the runner volume of each connecting tube (4) is each unequal, so each part liquid reaches converging for connecting tube (4) and is connected to end Time is different, to realize the sequential flowing of more parts of liquid.
Description
Technical field
The present invention relates to microfluidic arts, more particularly to a kind of method for realizing the more parts of spontaneous sequential flowings of liquid
And device.
Background technique
In biological and chemical field, it is frequently encountered the operation purified to certain substance, is generally required in purification
Plurality of liquid (reagent treatment) is successively handled sample to be purified.Currently, above-mentioned purification operations need artificial one time one
Different reagent treatments is separately added into sample secondaryly, duplicate reagent adding operation occupies people's a large amount of working time,
Seriously affect working efficiency.
Therefore, how to be added by simpler operation realization plurality of reagents to the successively sequence of sample, to save labor
The dynamic time improves working efficiency, becomes those skilled in the art's technical problem urgently to be resolved.
Summary of the invention
In view of this, the present invention provides a kind of method and device for realizing the more parts of spontaneous sequential flowings of liquid, this method
Worker can be made to realize that plurality of reagents is added to the successively sequence of sample by simpler operation with device, to effectively save
Working time is saved, working efficiency is improved.
In order to achieve the above object, the invention provides the following technical scheme:
A method of realizing the more parts of spontaneous sequential flowings of liquid, comprising:
Multiple closed containers with the number corresponding number of the more parts of liquid are taken, every portion liquid is located at not
In the same closed container；
Multiple connecting tubes with the number corresponding number of the more parts of liquid are taken, when the volume of multiple closed containers is each
When not identical, multiple connecting tubes are taken as runner volume and are equal, more when the volume of multiple closed containers is all the same
A connecting tube is taken as that runner volume is each unequal, and connection is converged in one end of multiple connecting tubes, and the other end is respectively and not
Same closed container connection；
Adjusting the position of the closed container, not block the liquid in each closed container described closed
The interface of container and the connecting tube, into the system of multiple closed containers and multiple connecting tube compositions, inflation adds
Pressure makes the internal pressure of the system be greater than external pressure；
Adjusting the position of the closed container again, to block the liquid in each closed container described close
Close the interface of container Yu the connecting tube；
The volume of the turned on outside for converging connection end and the system of the connecting tube, each closed container is protected
Hold it is constant, liquid described in the gas push in the closed container to the connecting tube converge connection end flow.
Preferably, in the above-mentioned methods, it is different to be taken as volume for multiple closed containers, by adjusting each described
Volume fraction between closed container adjusts the sequence for converging connection end that the liquid flows to the connecting tube.
Preferably, in the above-mentioned methods, it is identical to be taken as volume for multiple closed containers, by adjusting each connection
Length ratio between pipe adjusts the sequence for converging connection end that the liquid flows to the connecting tube.
A kind of device for realizing the more parts of spontaneous sequential flowings of liquid, comprising:
With multiple closed containers of the number corresponding number of the more parts of liquid, the closed container for placing respectively respectively
Part liquid；
With multiple connecting tubes of the number corresponding number of the more parts of liquid, company is converged in one end of multiple connecting tubes
Logical, the other end is connected to from the different closed containers respectively, and the volume of multiple closed containers is different, and multiple institutes
State that connecting tube runner volume is equal or the volume of multiple closed containers is all the same, and multiple connecting tube runners
Volume is each unequal；
Pressurizer, the pressurizer are used into the system of multiple closed containers and multiple connecting tube compositions fill
Gas pressurization.
Preferably, in above-mentioned apparatus, the connection end of converging of the connecting tube is connected to one end of microchannel, the micro-pipe
The other end in road is communicated with exhaust valve.
Preferably, in above-mentioned apparatus, the exhaust valve is permeability cell or the adjustable exhaust valve of gas flux.
Preferably, in above-mentioned apparatus, the connection end of converging of the connecting tube is connected to one end of microchannel, the micro-pipe
Road is the silicone tube made of poromeric material.
Preferably, in above-mentioned apparatus, the microchannel is PDMS chip.
Preferably, in above-mentioned apparatus, the microchannel is non-breathable pipeline or non-breathable chip.
Preferably, in above-mentioned apparatus, the closed container and/or the pressurizer are syringe.
It is first according to the above technical scheme it is found that in the method provided by the invention for realizing the more parts of spontaneous sequential flowings of liquid
Inflating pressure in the system first formed to closed container and connecting tube makes the internal pressure of system be greater than external pressure, then leads to
The closure for crossing liquid stops the gas of a part of High Voltage respectively, finally leads the outside for converging connection end and system of connecting tube
It is logical, make to form pressure difference between closed container and connecting tube, then liquid neous flow under the action of high pressure gas, and due to each
When a closed container volume is different, the runner volume of each connecting tube is equal or each closed container volume is homogeneous
Meanwhile the runner volume of each connecting tube is each unequal, so each part liquid reaches the time for converging connection end of connecting tube not
Together, to realize the sequential flowing of more parts of liquid.In conclusion method provided by the invention can be realized the spontaneous of more parts of liquid
Sequential flowing, therefore only need once-through operation that plurality of reagents can be realized and be added to the successively sequence of sample, when reaching saving labour
Between, improve working efficiency purpose.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
The embodiment of invention for those of ordinary skill in the art without creative efforts, can also basis
The attached drawing of offer obtains other attached drawings.
Fig. 1 is a kind of schematic diagram for device for realizing the more parts of spontaneous sequential flowings of liquid that the embodiment of the present invention one provides；
Fig. 2 is the experimental result schematic diagram of Fig. 1；
Fig. 3 is a kind of schematic diagram of device for realizing the more parts of spontaneous sequential flowings of liquid provided by Embodiment 2 of the present invention；
Fig. 4 is the experimental result schematic diagram of Fig. 3.
In the figure, it is marked as
1, pressurizer；2, gas-adding pipe；21, intake valve；3, closed container；4, connecting tube；5, microchannel.
Specific embodiment
In order to make it easy to understand, the invention will be further described with reference to the accompanying drawing.
It is a kind of showing for device for realizing the more parts of spontaneous sequential flowings of liquid that the embodiment of the present invention one provides referring to Fig. 1
It is intended to, which includes pressurizer 1, closed container 3 and connecting tube 4, wherein part of the quantity of closed container 3 and more parts of liquid
Number corresponds to, and for closed container 3 for placing each part liquid respectively, the volume of multiple closed containers 3 is different；The number of connecting tube 4
Amount is also corresponding with the number of more parts of liquid, and the runner volume of multiple connecting tubes 4 is equal, and company is converged in one end of multiple connecting tubes 4
Logical, the other end is connected to from different closed containers 3 respectively；Pressurizer 1 is used for multiple closed containers 3 and 4 groups of multiple connecting tubes
At system in inflating pressure.
In embodiment one, pressurizer 1 and closed container 3 are syringe, specifically, using the syringe of 20ml as pressurization
Device 1, three 5ml syringes are connected by gas-adding pipe 2 with pressurizer 1 as closed container 3, by three closed containers 3, gas-adding pipe
2 have intake valve 21 close to the position of closed container 3.Three closed containers 3 are fixed to the position of 1ml, 3ml and 5ml respectively,
And 100 microlitres of blue ink a, red ink b and green ink c are injected separately into three closed containers 3.Closed container 3
End is connected with the connecting tube 4 that runner volume is equal, and three connecting tubes 4 are connect by four-way pipe with microchannel 5, micro-tube
5 end is connected with exhaust valve (unmarked in figure).
After finishing device assembling, the exhaust valve of 5 end of micro-tube is closed, intake valve 21 is opened, by three closed containers 3
It lays flat, ink is made not block the outlet of closed container 3.Pressurizer 1 is shifted onto the position 5ml and fixation by the position 20ml, close into
Closed container 3 is placed vertically, ink is made to block the outlet of closed container 3 by air valve 21, initial inside three closed containers 3
Pressure is equal.Slowly open the exhaust valve of 5 end of microchannel, it can be seen that as shown in Figure 2 as a result, as shown in Figure 2, inner bulk
Ink corresponding to the maximum closed container 3 of product flows out at first, and the ink in the small closed container 3 of other internal volumes is then successively
Outflow.
Referring to Fig. 3, for a kind of showing for device for realizing the more parts of spontaneous sequential flowings of liquid provided by Embodiment 2 of the present invention
It is intended to, which includes pressurizer 1, closed container 3 and connecting tube 4, wherein part of the quantity of closed container 3 and more parts of liquid
Number corresponds to, and for closed container 3 for placing each part liquid respectively, the volume of multiple closed containers 3 is identical；The quantity of connecting tube 4
Corresponding with the number of more parts of liquid, the runner volume of multiple connecting tubes 4 is each unequal, and connection is converged in one end of multiple connecting tubes 4,
The other end is connected to from different closed containers 3 respectively；What pressurizer 1 was used to form to multiple closed containers 3 and multiple connecting tubes 4
Inflating pressure in system.
In embodiment two, pressurizer 1 and closed container 3 are syringe, specifically, using the syringe of 20ml as pressurization
Device 1, three 5ml syringes are connected by gas-adding pipe 2 with pressurizer 1 as closed container 3, by three closed containers 3, gas-adding pipe
2 have intake valve 21 close to the position of closed container 3.Three closed containers 3 are fixed to the position of 2ml, and close at three
It closes in container 3 and is injected separately into 100 microlitres of blue ink a, red ink b and green ink c.The end of closed container 3 and runner
Each unequal connecting tube 4 of volume is connected, wherein the length that blue ink a is correspondingly connected with pipe 4 is 10cm, and red ink b is corresponding
The length of connecting tube 4 is 20cm, and the length that green ink c is correspondingly connected with pipe 4 is 40cm, three connecting tubes 4 by four-way pipe with
Microchannel 5 connects, and the end of micro-tube 5 is connected with exhaust valve (unmarked in figure).
After finishing device assembling, the exhaust valve of 5 end of micro-tube is closed, intake valve 21 is opened, by three closed containers 3
It lays flat, ink is made not block the outlet of closed container 3.Pressurizer 1 is shifted onto the position 5ml and fixation by the position 20ml, close into
Closed container 3 is placed vertically, ink is made to block the outlet of closed container 3 by air valve 21, initial inside three closed containers 3
Pressure is equal.Slowly open the exhaust valve of 5 end of microchannel, it can be seen that as shown in Figure 4 as a result, as shown in Figure 4, connecting tube
4 is longer, and the time that liquid (ink) enters microchannel 5 is more late, to form sequential flowing of the more parts of liquid in microchannel 5.
In specific practical application, microchannel 5 can be PDMS chip, or can be the silica gel made of poromeric material
Pipe, when microchannel 5 is made of poromeric material, then may not necessarily be communicated with exhaust valve in end.Certainly, microchannel 5 can also
Think non-breathable pipeline or non-breathable chip, and be communicated with exhaust valve in end, the exhaust valve of 5 end of microchannel can be with
For permeability cell or the adjustable exhaust valve of gas flux.
The present invention also provides a kind of methods for realizing the more parts of spontaneous sequential flowings of liquid, this method comprises:
Take multiple closed containers 3 with the number corresponding number of more parts of liquid, every portion liquid is located at different close
It closes in container 3；
Multiple connecting tubes 4 with the number corresponding number of more parts of liquid are taken, when the volume of multiple closed containers 3 is different
When, multiple connecting tubes 4 are taken as runner volume and are equal, and when the volume of multiple closed containers 3 is all the same, multiple connecting tubes 4 are taken
Each unequal for runner volume, connection is converged in one end of multiple connecting tubes 4, and the other end is connected to from different closed containers 3 respectively；
The position of adjustment closed container 3 makes the liquid in each closed container 3 not block closed container 3 and connecting tube 4
Interface, inflating pressure in the system formed to multiple closed containers 3 and multiple connecting tubes 4 is greater than the internal pressure of system
External pressure；
The position for adjusting closed container 3 again makes the liquid in each closed container 3 block closed container 3 and connecting tube
4 interface；
By the turned on outside for converging connection end and system of connecting tube 4, the volume of each closed container 3 is remained unchanged, close
The gas pushed liquid closed in container 3 is flowed to the connection end of converging of connecting tube 4.
It, can be by adjusting each if to be taken as volume different for multiple closed containers 3 in specific practical application
Volume fraction between closed container 3 adjusts the sequence for converging connection end that liquid flows to connecting tube 4；If multiple closed
Container 3 is taken as that volume is identical, then can flow to company by adjusting the length ratio between each connecting tube 4 to adjust liquid
The sequence for converging connection end of adapter tube 4.
In the method provided by the invention for realizing the more parts of spontaneous sequential flowings of liquid, first to closed container 3 and connecting tube 4
Inflating pressure in the system of composition makes the internal pressure of system be greater than external pressure, is then stopped respectively by the closure of liquid
The gas of a part of High Voltage makes closed container 3 and connects finally by the turned on outside for converging connection end and system of connecting tube 4
Pressure difference is formed between adapter tube 4, then liquid neous flow under the action of high pressure gas, and due to each 3 volume of closed container
When different, when the runner volume of each connecting tube 4 is equal or 3 volume of each closed container is all the same, each connection
The runner volume of pipe 4 is each unequal, so the time for converging connection end that each part liquid reaches connecting tube 4 is different, to realize
The sequential flowing of more parts of liquid.In conclusion method provided by the invention can be realized the spontaneous sequential flowing of more parts of liquid, because
This needs once-through operation that successively sequence addition of the plurality of reagents to sample can be realized, and reaches and saves working time, improves work
The purpose of efficiency.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
A variety of modifications of embodiment will be readily apparent to those skilled in the art, it is as defined herein general
Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, the present invention will not
It can be restricted to embodiment illustrated herein, and be to fit to consistent with the principles and novel features disclosed in this article most wide
Range.
Claims (9)
1. a kind of method for realizing the more parts of spontaneous sequential flowings of liquid characterized by comprising
Multiple closed containers (3) with the number corresponding number of the more parts of liquid are taken, every portion liquid is located at not
In the same closed container (3)；
Multiple connecting tubes (4) with the number corresponding number of the more parts of liquid are taken, when the volume of multiple closed containers (3)
When different, multiple connecting tubes (4) are taken as runner volume and are equal, when the volume of multiple closed containers (3) is equal
When identical, multiple connecting tubes (4) are taken as that runner volume is each unequal, and connection is converged in one end of multiple connecting tubes (4),
The other end is connected to from the different closed containers (3) respectively；
Adjusting the position of the closed container (3), not block the liquid in each closed container (3) described close
The interface for closing container (3) Yu the connecting tube (4) is formed to multiple closed containers (3) and multiple connecting tubes (4)
Inflating pressure in system makes the internal pressure of the system be greater than external pressure；
The position for adjusting the closed container (3) again makes described in the liquid in each closed container (3) blocks
The interface of closed container (3) and the connecting tube (4)；
By the turned on outside for converging connection end and the system of the connecting tube (4), the volume of each closed container (3)
It remains unchanged, liquid described in the gas push in the closed container (3) is flowed to the connection end of converging of the connecting tube (4).
2. the method according to claim 1, wherein to be taken as volume different for multiple closed containers (3),
The connecting tube (4) is flowed to by adjusting the volume fraction between each closed container (3) to adjust the liquid
Converge the sequence at connection end.
3. passing through the method according to claim 1, wherein to be taken as volume identical for multiple closed containers (3)
Adjust the length ratio between each connecting tube (4) to adjust that the liquid flows to the connecting tube (4) converges company
The sequence of go side.
4. a kind of device for realizing the more parts of spontaneous sequential flowings of liquid characterized by comprising
With multiple closed containers (3) of the number corresponding number of the more parts of liquid, the closed container (3) for placing respectively
Each part liquid；
Converge company with one end of multiple connecting tubes (4) of the number corresponding number of the more parts of liquid, multiple connecting tubes (4)
Logical, the other end is connected to from the different closed containers (3) respectively, and the connecting tube (4) converges connection end and microchannel (5)
One end connection, the other end of the microchannel (5) is communicated with exhaust valve, each not phase of the volume of multiple closed containers (3)
Together, the multiple connecting tube (4) runner volumes are equal or the volume of multiple closed containers (3) is all the same, and more
A connecting tube (4) runner volume is each unequal；
Pressurizer (1), what the pressurizer (1) was used to form to multiple closed containers (3) and multiple connecting tubes (4)
Inflating pressure in system.
5. device according to claim 4, which is characterized in that the exhaust valve is permeability cell or the adjustable row of gas flux
Air valve.
6. device according to claim 4, which is characterized in that the connecting tube (4) converges connection end and microchannel (5)
One end connection, the microchannel (5) be the silicone tube made of poromeric material.
7. device according to claim 4, which is characterized in that the microchannel (5) is PDMS chip.
8. device according to claim 4, which is characterized in that the microchannel (5) is non-breathable pipeline or non-
Gas chip.
9. the device according to any one of claim 4~8, which is characterized in that the closed container (3) and/or institute
Stating pressurizer (1) is syringe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710500139.6A CN107328949B (en) | 2017-06-27 | 2017-06-27 | A kind of method and device for realizing the more parts of spontaneous sequential flowings of liquid |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710500139.6A CN107328949B (en) | 2017-06-27 | 2017-06-27 | A kind of method and device for realizing the more parts of spontaneous sequential flowings of liquid |
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| CN107328949A CN107328949A (en) | 2017-11-07 |
| CN107328949B true CN107328949B (en) | 2019-05-03 |
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