CN107296636A - A kind of injectable styptic sponge device, syringe and external member - Google Patents
A kind of injectable styptic sponge device, syringe and external member Download PDFInfo
- Publication number
- CN107296636A CN107296636A CN201710325860.6A CN201710325860A CN107296636A CN 107296636 A CN107296636 A CN 107296636A CN 201710325860 A CN201710325860 A CN 201710325860A CN 107296636 A CN107296636 A CN 107296636A
- Authority
- CN
- China
- Prior art keywords
- syringe
- styptic sponge
- polyvinyl alcohol
- chitosan
- styptic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 61
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 61
- 229920001661 Chitosan Polymers 0.000 claims abstract description 49
- 230000023597 hemostasis Effects 0.000 claims abstract description 36
- 239000002131 composite material Substances 0.000 claims abstract description 18
- 238000002347 injection Methods 0.000 claims abstract description 16
- 239000007924 injection Substances 0.000 claims abstract description 16
- 229920002554 vinyl polymer Polymers 0.000 claims abstract description 11
- 238000005187 foaming Methods 0.000 claims abstract description 10
- 208000027418 Wounds and injury Diseases 0.000 claims description 28
- 206010052428 Wound Diseases 0.000 claims description 23
- 229920000642 polymer Polymers 0.000 claims description 20
- 150000001298 alcohols Chemical class 0.000 claims description 15
- 239000007864 aqueous solution Substances 0.000 claims description 13
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical group CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims description 10
- 239000003431 cross linking reagent Substances 0.000 claims description 10
- 239000004088 foaming agent Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 9
- 230000006835 compression Effects 0.000 claims description 8
- 238000007906 compression Methods 0.000 claims description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical group O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 6
- 238000005213 imbibition Methods 0.000 claims description 6
- 239000006260 foam Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 229920000742 Cotton Polymers 0.000 claims description 4
- -1 polypropylene Polymers 0.000 claims description 4
- 229920002261 Corn starch Polymers 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 239000008120 corn starch Substances 0.000 claims description 3
- 229940099112 cornstarch Drugs 0.000 claims description 3
- 238000005553 drilling Methods 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 230000029663 wound healing Effects 0.000 claims description 3
- 238000006116 polymerization reaction Methods 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 238000003860 storage Methods 0.000 abstract description 2
- 229940068984 polyvinyl alcohol Drugs 0.000 description 45
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 45
- 230000000740 bleeding effect Effects 0.000 description 6
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 6
- 230000006378 damage Effects 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 150000002085 enols Chemical class 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 229940015043 glyoxal Drugs 0.000 description 3
- 238000010276 construction Methods 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 230000002439 hemostatic effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical group O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/1204—Type of occlusion temporary occlusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/1219—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices expandable in contact with liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B2017/12004—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for haemostasis, for prevention of bleeding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Medical Informatics (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
Abstract
Hinder for sinus, duct is hindered, the injection hemostasis external member of perforating wound, including injectable styptic sponge device and syringe；Injectable styptic sponge device includes styptic sponge block and connecting line, and styptic sponge block is polyvinyl alcohol-chitosan composite sponge, and cylinder is sewed with " ten " font X-ray developing line on surface；Syringe includes：Injector push-rod, syringe cock, push rod deck, syringe cylinder, syringe cap；The styptic sponge of styptic sponge block is made, is prepared by polyvinyl alcohol and chitosan foaming, is three-decker, intermediate layer is polyvinyl alcohol, and the upper and lower are polyvinyl alcohol and chitosan complexes, and the ratio of chitosan is 3 10%；Styptic sponge device is filled in syringe cylinder during storage, takes out syringe cap when using first, then syringe is inserted in wound, and pushing syringe push rod is filled in styptic sponge device in wound.
Description
Technical field
The present invention relates to medical instruments field, it is related to a kind of injectable styptic sponge device, syringe and external member, also relates to
And a kind of styptic sponge and its preparation method.
Background technology
First aid hemostasis is the important step of War injury bleeding first aid, and research data shows, the dead topmost original of War injury
Because being that the wounded are sent to before treatment mechanism bleeding up to 50%；Even if the wounded are sent to treatment mechanism, bleeding is still that war wound is dead
And the main reason of various complication.Hemostasis by finger pressing, dressing, bandage or triangle bandage compression wrap are used conventional Hemostasis more
Prick hemostasis, autologous hemostasis by compression, tourniquet hemostasis, plugging etc..And the hole that War injury bleeding major part, which is bullet, shell fragment, to be caused
Hole wound, sinus injure the bleeding of similar injury types, and such wound is typically stopped blooding by the way of gauze filling, but deposits
Bleeding stopping period length, using inconvenience, be adhered the drawbacks such as wound.Therefore the efficient War injury hemostasis that study a kind of convenience, can save oneself
Equipment is the focus paid close attention to both at home and abroad at present, in addition, corresponding hemostatic material research is also current urgent task.
The content of the invention
The technical problem to be solved in the present invention is how to design a kind of live wire sinus wound, duct wound and perforating wound of being applied to go out
Blood first aid efficiently, conveniently, be easy to the hemostasis equipment removed, and the hemostatic material matched with the hemostasis device.
In order to solve the above technical problems, the present invention provides a kind of injectable styptic sponge device, including multiple hemostasis seas
Continuous block and connecting line, the styptic sponge block are connected with each other by connecting line, and the styptic sponge is taken out rapidly after being easy to hemostasis
Block.
Preferably, the styptic sponge block is cylinder, a diameter of 8-10mm of cylinder, and the height of cylinder is
5-50mm.
Preferably, heat seal or " ten " font X-ray developing line is sewed with the styptic sponge block surface, can be seen by X-ray
Examine, check whether that all styptic sponge blocks have all been removed.
Preferably, the connecting line is cotton thread, wire or plastic cord.
Preferably, the styptic sponge block is polyvinyl alcohol-chitosan composite sponge, with quick imbibition, highly expanded
Rate, hemostasis, promotion wound healing function.
Preferably, the polyvinyl alcohol-chitosan composite sponge is prepared by polyvinyl alcohol and chitosan foaming
Sponge, is three-decker, and intermediate layer is polyvinyl alcohol, and the upper and lower are polyvinyl alcohol and chitosan complexes, chitosan
Ratio is 3-10%.
The present invention also provides a kind of syringe, is exclusively used in loading and injects injectable styptic sponge device described above,
The syringe includes：Injector push-rod, syringe cock, push rod deck, syringe cylinder, syringe cap；The syringe cylinder
For hollow cylinder, for loading at end opening before and after the injectable styptic sponge device, the syringe cylinder, front opening
The syringe cap is cased with, rear end is formed with a support and referred at portion, open rearward end provided with the syringe cock, the syringe rotation
Center drilling is filled in, the injector push-rod is inserted in the syringe cylinder through syringe cock, the injector push-rod front end
Provided with the push rod deck, rear end is formed with a push handle, and the push rod deck is used for the injectable of filling with stopping
Blood sponge device releases the syringe cylinder；The syringe cap is cylindricality sleeve pipe, and internal diameter is not less than the syringe cylinder external diameter,
The syringe cylinder can be inserted in syringe cap, for preventing in syringe cylinder the injectable styptic sponge device from front end
Come off at opening, it is ensured that the injectable is safe and healthy with styptic sponge device.
Preferably, the front opening of the syringe cylinder is large aperture opening, is easy to described in the syringe cylinder
Injectable is released rapidly with styptic sponge device.
Preferably, the push handle of the injector push-rod is " ten " shape push handle, on the premise of mechanical property has been effectively ensured,
The total quality of syringe is reduced again.
Preferably, the syringe material is polypropylene material.
Based on styptic sponge device described above and syringe, the invention provides one kind injection hemostasis external member, for sinus
Road wound, duct wound, the hemostasis of perforating wound, including injectable described above styptic sponge device and syringe, facilitate supporting make
With.
Another object of the present invention is to provide a kind of styptic sponge for being used to make styptic sponge block described above, is by poly- second
Enol and chitosan foaming are prepared, and the styptic sponge is three-decker, and intermediate layer is polyvinyl alcohol, and the upper and lower are
Polyvinyl alcohol and chitosan complexes, the ratio of chitosan is 3-10%.
Simultaneously there is provided the preparation method of more than one styptic sponges, comprise the following steps：
Prepare polyvinyl alcohol water solution；
Polyvinyl alcohol and chitosan mixed aqueous solution are prepared, the ratio of chitosan is 3-10%；
Two kinds of aqueous solution are separately added into crosslinking agent, foaming agent, emulsifying agent stirs, pure polyvinyl alcohol pre-polymerization is made
Body and polyvinyl alcohol/chitosan complexes performed polymer；
By polyvinyl alcohol/chitosan complexes performed polymer, pure polyvinyl alcohol performed polymer, polyvinyl alcohol/chitosan complexes
Performed polymer order pours into mould, is molded in the case where forming temperature is 50-70 DEG C, by washing, dries, obtains composite foam sponge；
The styptic sponge of compression can be obtained by hot-forming.
Preferably, the crosslinking agent be formaldehyde or glyoxal, the foaming agent be farina or cornstarch, it is described
Emulsifying agent is pentane, and forming temperature is 60 DEG C.
It can be seen from the above technical proposal that injectable styptic sponge device uses injection system, special syringe handle is used
Injectable sponge device push-in sinus, hole class wound, injectable sponge device enters after wound, after the moisture in draw blood
Rapid expansion, oppresses wound, so as to reach the purpose of hemostasis.All styptic sponge blocks are connected further through same cotton thread,
Easily taken out in post processing, and heat seal has X-ray developing line on every piece of styptic sponge block, or X-ray developing line is sewed with, it is convenient in doctor
Institute is checked by X-ray machine, prevents sponge and is detained in vivo.
Present invention injection hemostasis external member uses syringe form, by the way that styptic sponge is pushed into traumatic wounds, passes through sea
The features such as continuous imbibition, expansion compression, accelerates hemostasis, one-hand operation, and is easy to take out, convenient post-treatment.Prepared stops
Composite construction is made using polyvinyl alcohol and chitosan in sea of blood silk floss, is cured with quick imbibition, highly expanded rate, hemostasis, promotion wound
Close function.
Brief description of the drawings
Fig. 1 is injectable styptic sponge apparatus structure schematic diagram provided in an embodiment of the present invention.
Fig. 2 is styptic sponge block pictorial diagram provided in an embodiment of the present invention.
Fig. 3 is syringe construction figure provided in an embodiment of the present invention.
Fig. 4 is syringe design sketch provided in an embodiment of the present invention.
Fig. 5 is injection hemostasis external member structural representation provided in an embodiment of the present invention.
Fig. 6 is that injection hemostasis external member provided in an embodiment of the present invention uses schematic diagram.
Fig. 7 is the puncture site X-ray figure provided in an embodiment of the present invention using injection hemostasis external member.
Wherein, 100- injectables styptic sponge device, 101- styptic sponges block, 102- connecting lines, 103-X light show
Hachure, 200- syringes, 201- injector push-rods, the cock of 202- syringes, 203- push rods deck, 204- syringe cylinders,
205- syringe caps.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, below in conjunction with accompanying drawing 1-7 and implementation
Example, the present invention will be described in further detail.It should be appreciated that specific embodiment described herein is only to explain this hair
It is bright, it is not intended to limit the present invention.
Embodiment one：
The embodiment of the present invention provides injectable styptic sponge device, including multiple styptic sponge blocks 101 and connecting line
102, the styptic sponge block 101 is connected with each other by connecting line 102, and the styptic sponge block is taken out rapidly after being easy to hemostasis
101, the styptic sponge block 101 is cylinder, and a diameter of 8mm of cylinder, the height of cylinder is 5mm, the hemostasis sea
Heat seal " ten " font X-ray developing line, can be observed by X-ray on the continuous surface of block 101, check whether all styptic sponge blocks
101 have all been removed, and the connecting line 102 is plastic cord, and styptic sponge block 101 is polyvinyl alcohol-chitosan composite sponge,
With quick imbibition, highly expanded rate, hemostasis, promote wound healing function, the polyvinyl alcohol-chitosan composite sponge be by
The sponge that polyvinyl alcohol and chitosan foaming are prepared, is three-decker, intermediate layer is polyvinyl alcohol, and the upper and lower are poly-
Vinyl alcohol and chitosan complexes, the ratio of chitosan is 3%.
Embodiment two：
The embodiment of the present invention provides injectable styptic sponge device, including multiple styptic sponge blocks 101 and connecting line
102, the styptic sponge block 101 is connected with each other by connecting line 102, and the styptic sponge block 101 is cylinder, cylinder
A diameter of 10mm, the height of cylinder is to be sewed with " ten " font X-ray developing line, institute on 50mm, the surface of styptic sponge block 101
Connecting line 102 is stated for wire, styptic sponge block 101 is polyvinyl alcohol-chitosan composite sponge, the polyvinyl alcohol-shell
Glycan composite sponge is the sponge prepared by polyvinyl alcohol and chitosan foaming, is three-decker, intermediate layer is polyethylene
Alcohol, the upper and lower are polyvinyl alcohol and chitosan complexes, and the ratio of chitosan is 10%.
Embodiment three：
The embodiment of the present invention provides injectable styptic sponge device, including multiple styptic sponge blocks 101 and connecting line
102, the styptic sponge block 101 is connected with each other by connecting line 102, and the styptic sponge block 101 is cylinder, cylinder
A diameter of 9mm, the height of cylinder is to be sewed with " ten " font X-ray developing line, institute on 25mm, the surface of styptic sponge block 101
Connecting line 102 is stated for cotton thread, styptic sponge block 101 is polyvinyl alcohol-chitosan composite sponge, the polyvinyl alcohol-shell gathers
Sugared composite sponge is the sponge prepared by polyvinyl alcohol and chitosan foaming, is three-decker, intermediate layer is polyvinyl alcohol,
The upper and lower are polyvinyl alcohol and chitosan complexes, and the ratio of chitosan is 5%.
Example IV：
The embodiment of the present invention provides syringe, is exclusively used in loading and injects injectable styptic sponge device described above
100, the syringe 200 includes：Injector push-rod 201, syringe cock 202, push rod deck 203, syringe cylinder 204, note
Emitter cap 205；The syringe cylinder 204 is hollow cylinder, described for loading the injectable styptic sponge device 100
The syringe cap 205 is cased with end opening before and after syringe cylinder 204, front opening, rear end is formed with a support and refers to portion, and rear end is opened
The syringe cock 202 is provided with mouthful, the center drilling of syringe cock 202, the injector push-rod 201 passes through injection
Device cock 202 is inserted in the syringe cylinder 204, and the front end of injector push-rod 201 is provided with the push rod deck 203, rear end
A push handle is formed with, the push rod deck 203 is used to the injectable styptic sponge device 100 of filling release institute
State syringe cylinder 204；The syringe cap 205 is cylindricality sleeve pipe, and internal diameter is not less than the external diameter of syringe cylinder 204, the note
Emitter cylinder 204 can be inserted in syringe cap 205, for preventing the injectable styptic sponge device 100 in syringe cylinder 204
Come off at front opening, it is ensured that the injectable is safe and healthy with styptic sponge device 100, the syringe cylinder 204
Front opening is large aperture opening, is easy to the injectable styptic sponge device 100 in the syringe cylinder 204 is rapid
Release, the push handle of the injector push-rod 201 is " ten " shape push handle, on the premise of mechanical property has been effectively ensured, and is reduced again
The total quality of syringe 200, the material of syringe 200 is polypropylene material.
Embodiment five：
The embodiment of the present invention provides injection hemostasis external member, hinders for sinus, duct is hindered, the hemostasis of perforating wound, including implement
The syringe 200 described in styptic sponge device 100 and example IV of injectable described in example three, is conveniently supported the use.Structure design
Based on the injection power-assisted filling high imbibition expanded tampon technology of sponge, during storage, styptic sponge device 100 is filled in syringe cylinder
In 204；In use, taking out syringe cap 205 first, then syringe 200 is inserted in wound, pushing syringe push rod 201,
Styptic sponge device 100 is filled in wound.
Embodiment six：
The embodiment of the present invention provides the styptic sponge for making styptic sponge block described above, is by polyvinyl alcohol and shell
Glycan foaming is prepared, and the styptic sponge is three-decker, and intermediate layer is polyvinyl alcohol, and the upper and lower are polyvinyl alcohol
And chitosan complexes, the ratio of chitosan is 3%.
Embodiment seven：
The embodiment of the present invention provides the styptic sponge for making styptic sponge block described above, is by polyvinyl alcohol and shell
Glycan foaming is prepared, and the styptic sponge is three-decker, and intermediate layer is polyvinyl alcohol, and the upper and lower are polyvinyl alcohol
And chitosan complexes, the ratio of chitosan is 10%.
Embodiment eight：
The embodiment of the present invention provides the preparation method of styptic sponge described in embodiment six, comprises the following steps：Prepare poly- second
The enol aqueous solution；Polyvinyl alcohol and chitosan mixed aqueous solution are prepared, the ratio of chitosan is 3%；Two kinds of aqueous solution are distinguished
Crosslinking agent is added, foaming agent, emulsifying agent stirs, and pure polyvinyl alcohol performed polymer and polyvinyl alcohol/chitosan complexes are made
Performed polymer；By polyvinyl alcohol/chitosan complexes performed polymer, pure polyvinyl alcohol performed polymer, polyvinyl alcohol/chitosan complexes are pre-
Aggressiveness order pours into mould, is molded in the case where forming temperature is 50 DEG C, by washing, dries, obtains composite foam sponge；Pass through heat
Molded to obtain the styptic sponge of compression, the crosslinking agent is formaldehyde, and the foaming agent is farina, the emulsification
Agent is pentane.
Embodiment nine：
The embodiment of the present invention provides the preparation method of styptic sponge described in embodiment six, comprises the following steps：Prepare poly- second
The enol aqueous solution；Polyvinyl alcohol and chitosan mixed aqueous solution are prepared, the ratio of chitosan is 10%；Two kinds of aqueous solution are distinguished
Crosslinking agent is added, foaming agent, emulsifying agent stirs, and pure polyvinyl alcohol performed polymer and polyvinyl alcohol/chitosan complexes are made
Performed polymer；By polyvinyl alcohol/chitosan complexes performed polymer, pure polyvinyl alcohol performed polymer, polyvinyl alcohol/chitosan complexes are pre-
Aggressiveness order pours into mould, is molded in the case where forming temperature is 70 DEG C, by washing, dries, obtains composite foam sponge；Pass through heat
Molded to obtain the styptic sponge of compression, the crosslinking agent is glyoxal, and the foaming agent is cornstarch, the emulsification
Agent is pentane.
Embodiment ten：
The embodiment of the present invention provides the preparation method of styptic sponge described in embodiment six, comprises the following steps：Prepare poly- second
The enol aqueous solution；Polyvinyl alcohol and chitosan mixed aqueous solution are prepared, the ratio of chitosan is 5%；Two kinds of aqueous solution are distinguished
Crosslinking agent is added, foaming agent, emulsifying agent stirs, and pure polyvinyl alcohol performed polymer and polyvinyl alcohol/chitosan complexes are made
Performed polymer；By polyvinyl alcohol/chitosan complexes performed polymer, pure polyvinyl alcohol performed polymer, polyvinyl alcohol/chitosan complexes are pre-
Aggressiveness order pours into mould, is molded in the case where forming temperature is 60 DEG C, by washing, dries, obtains composite foam sponge；Pass through heat
Molded to obtain the styptic sponge of compression, the crosslinking agent is glyoxal, and the foaming agent is farina, the breast
Agent is pentane.
The present invention designs and is prepared for polyvinyl alcohol-chitosan composite wood of water absorbing properties and expansion character comparative superiority
The styptic sponge of material, and there is provided applied to the device of the styptic sponge, syringe and injection external member, the injection external member can be preferably
Be used for sinus wound, duct wound, the hemostasis of perforating wound, preliminary experiment show that the injection external member is easy to use, and hemostasis is rapidly.
The present invention is expected to the hemostasis equipment as my army's first aid of battle field, hinders for live wire sinus, duct is hindered, the hemostasis of perforating wound, mainly
Individual soldier, even rescue group are provided to, Operation Medical Treatment Clinique and emergency medical unit can be also fitted to.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvement can also be made, replaces and changes.These, which improve, replace and changed, is not departing from by subsidiary right
It is required that and its on the premise of the scope of equivalent technologies, also should be regarded as protection scope of the present invention.
Claims (14)
1. a kind of injectable styptic sponge device, it is characterised in that including multiple styptic sponge blocks and connecting line, the hemostasis
Sponge block is connected with each other by connecting line, and the styptic sponge block is taken out rapidly after being easy to hemostasis.
2. injectable according to claim 1 styptic sponge device, it is characterised in that the styptic sponge block is cylinder
Body, a diameter of 8-10mm of cylinder, the height of cylinder is 5-50mm.
3. injectable according to claim 2 styptic sponge device, it is characterised in that on the styptic sponge block surface
Heat seal is sewed with " ten " font X-ray developing line, can be observed by X-ray, check whether that all styptic sponge blocks have all been taken
Go out.
4. injectable according to claim 3 styptic sponge device, it is characterised in that the connecting line is cotton thread, gold
Belong to silk or plastic cord.
5. injectable according to claim 4 styptic sponge device, it is characterised in that the styptic sponge block is poly- second
Enol-chitosan composite sponge, with quick imbibition, highly expanded rate, hemostasis, promotion wound healing function.
6. injectable according to claim 5 styptic sponge device, it is characterised in that the polyvinyl alcohol-chitosan
Composite sponge is the sponge prepared by polyvinyl alcohol and chitosan foaming, is three-decker, intermediate layer is polyvinyl alcohol, on
Layer and lower floor are polyvinyl alcohol and chitosan complexes, and the ratio of chitosan is 3-10%.
7. a kind of syringe, it is exclusively used in loading and injects one of the claim 1-6 injectables and filled with styptic sponge
Put, it is characterised in that the syringe includes：Injector push-rod, syringe cock, push rod deck, syringe cylinder, syringe
Cap；
The syringe cylinder is hollow cylinder, for loading the injectable styptic sponge device, the syringe cylinder before and after
The syringe cap is cased with end opening, front opening, rear end is formed with a support and referred at portion, open rearward end provided with the syringe
Cock, the syringe cock center drilling, the injector push-rod is inserted in the syringe cylinder through syringe cock, institute
Injector push-rod front end is stated provided with the push rod deck, rear end is formed with a push handle, the push rod deck is used for filling
The injectable release the syringe cylinder with styptic sponge device；
The syringe cap is cylindricality sleeve pipe, and internal diameter is not less than the syringe cylinder external diameter, and the syringe cylinder can insert injection
In device cap, for preventing that the injectable styptic sponge device comes off at front opening in syringe cylinder, it is ensured that it is described can
Injection styptic sponge device it is safe and healthy.
8. syringe according to claim 7, it is characterised in that the front opening of the syringe cylinder is opened for large aperture
Mouthful, it is easy to the injectable in the syringe cylinder to be released rapidly with styptic sponge device.
9. syringe according to claim 8, it is characterised in that the push handle of the injector push-rod is " ten " shape push handle,
On the premise of mechanical property has been effectively ensured, the total quality of syringe is reduced again.
10. syringe according to claim 9, it is characterised in that the syringe material is polypropylene material.
11. one kind injection hemostasis external member, hinders, duct is hindered, the hemostasis of perforating wound, it is characterised in that will including right for sinus
Ask any one of 1-6 injectable styptic sponge devices and the syringe described in claim any one of 7-10.
12. a kind of be used to make the styptic sponges of any one of the claim 1-3 styptic sponge blocks, be by polyvinyl alcohol and
Chitosan foaming is prepared, it is characterised in that the styptic sponge is three-decker, and intermediate layer is polyvinyl alcohol, upper strata and
Lower floor is polyvinyl alcohol and chitosan complexes, and the ratio of chitosan is 3-10%.
13. the preparation method of styptic sponge described in a kind of claim 12, it is characterised in that comprise the following steps：
Prepare polyvinyl alcohol water solution；
Polyvinyl alcohol and chitosan mixed aqueous solution are prepared, the ratio of chitosan is 3-10%；
Two kinds of aqueous solution are separately added into crosslinking agent, foaming agent, emulsifying agent stirs, be made pure polyvinyl alcohol performed polymer and
Polyvinyl alcohol/chitosan complexes performed polymer；
By polyvinyl alcohol/chitosan complexes performed polymer, pure polyvinyl alcohol performed polymer, polyvinyl alcohol/chitosan complexes pre-polymerization
Body order pours into mould, is molded in the case where forming temperature is 50-70 DEG C, by washing, dries, obtains composite foam sponge；
The styptic sponge of compression can be obtained by hot-forming.
14. the preparation method of styptic sponge according to claim 13, it is characterised in that the crosslinking agent is formaldehyde or second two
Aldehyde, the foaming agent is farina or cornstarch, and the emulsifying agent is pentane, and forming temperature is 60 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710325860.6A CN107296636B (en) | 2017-05-10 | 2017-05-10 | Hemostatic sponge device for injection, injector and kit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710325860.6A CN107296636B (en) | 2017-05-10 | 2017-05-10 | Hemostatic sponge device for injection, injector and kit |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107296636A true CN107296636A (en) | 2017-10-27 |
| CN107296636B CN107296636B (en) | 2024-04-02 |
Family
ID=60137795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710325860.6A Active CN107296636B (en) | 2017-05-10 | 2017-05-10 | Hemostatic sponge device for injection, injector and kit |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107296636B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107997802A (en) * | 2018-01-11 | 2018-05-08 | 四川大学华西医院 | The accurate hemostasis device of spatium interosseum |
| CN110946633A (en) * | 2019-11-26 | 2020-04-03 | 杭州电子科技大学 | Portable quick extrusion device |
| CN111195173A (en) * | 2018-11-19 | 2020-05-26 | 江苏昌吉永生物科技股份有限公司 | Injection type hemostatic applicator and preparation method thereof |
| CN115584050A (en) * | 2022-10-26 | 2023-01-10 | 上海七木医疗器械有限公司 | Gelatin sponge, preparation method thereof and embolism material prepared from gelatin sponge |
| CN116036353A (en) * | 2022-12-05 | 2023-05-02 | 上海七木医疗器械有限公司 | Absorbable embolic material and preparation method and application thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342381A (en) * | 2008-08-29 | 2009-01-14 | 暨南大学 | Preparation method for anti-inflammation adhesion-proof hemostatic sponge |
| US20100063459A1 (en) * | 2006-12-15 | 2010-03-11 | Orahn Preiss-Bloom | Gelatin-transglutaminase hemostatic dressings and sealants |
| CN101927027A (en) * | 2010-04-16 | 2010-12-29 | 哈尔滨工业大学 | Chitosan/carboxymethyl chitosan rapid hemostatic sponge and preparation method thereof |
| CN201959088U (en) * | 2011-02-24 | 2011-09-07 | 北京利明达医药科技有限公司 | Chitosan first aid hemostasis device |
| US20110311608A1 (en) * | 2010-06-16 | 2011-12-22 | Abbott Vascular, Inc. | Stable chitosan hemostatic implant and methods of manufacture |
| US20120065604A1 (en) * | 2010-09-13 | 2012-03-15 | Chao-Fu Chang | Degradable hemostatic sponge and extrusion system and method for manufacturing the same |
| CN102648985A (en) * | 2011-02-24 | 2012-08-29 | 温州中科应急急救包有限公司 | Chitosan emergent hemostasis material |
| CN203208224U (en) * | 2013-03-22 | 2013-09-25 | 朱新生 | Disposable surgical expansion hemostatic sponge |
| CN104490521A (en) * | 2014-12-22 | 2015-04-08 | 中国人民解放军第四军医大学 | Multi-functional dressing for firearm perforating wound in limbs |
-
2017
- 2017-05-10 CN CN201710325860.6A patent/CN107296636B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100063459A1 (en) * | 2006-12-15 | 2010-03-11 | Orahn Preiss-Bloom | Gelatin-transglutaminase hemostatic dressings and sealants |
| CN101342381A (en) * | 2008-08-29 | 2009-01-14 | 暨南大学 | Preparation method for anti-inflammation adhesion-proof hemostatic sponge |
| CN101927027A (en) * | 2010-04-16 | 2010-12-29 | 哈尔滨工业大学 | Chitosan/carboxymethyl chitosan rapid hemostatic sponge and preparation method thereof |
| US20110311608A1 (en) * | 2010-06-16 | 2011-12-22 | Abbott Vascular, Inc. | Stable chitosan hemostatic implant and methods of manufacture |
| US20120065604A1 (en) * | 2010-09-13 | 2012-03-15 | Chao-Fu Chang | Degradable hemostatic sponge and extrusion system and method for manufacturing the same |
| CN201959088U (en) * | 2011-02-24 | 2011-09-07 | 北京利明达医药科技有限公司 | Chitosan first aid hemostasis device |
| CN102648985A (en) * | 2011-02-24 | 2012-08-29 | 温州中科应急急救包有限公司 | Chitosan emergent hemostasis material |
| CN203208224U (en) * | 2013-03-22 | 2013-09-25 | 朱新生 | Disposable surgical expansion hemostatic sponge |
| CN104490521A (en) * | 2014-12-22 | 2015-04-08 | 中国人民解放军第四军医大学 | Multi-functional dressing for firearm perforating wound in limbs |
Non-Patent Citations (1)
| Title |
|---|
| 何谷;陈煜;张明明;王东旭;丛堃;范海波;周芳集: "聚乙烯醇/壳聚糖互穿聚合物海绵的制备及应用探索", 高分子材料科学与工程, vol. 27, no. 1 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107997802A (en) * | 2018-01-11 | 2018-05-08 | 四川大学华西医院 | The accurate hemostasis device of spatium interosseum |
| CN111195173A (en) * | 2018-11-19 | 2020-05-26 | 江苏昌吉永生物科技股份有限公司 | Injection type hemostatic applicator and preparation method thereof |
| CN110946633A (en) * | 2019-11-26 | 2020-04-03 | 杭州电子科技大学 | Portable quick extrusion device |
| CN115584050A (en) * | 2022-10-26 | 2023-01-10 | 上海七木医疗器械有限公司 | Gelatin sponge, preparation method thereof and embolism material prepared from gelatin sponge |
| CN116036353A (en) * | 2022-12-05 | 2023-05-02 | 上海七木医疗器械有限公司 | Absorbable embolic material and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107296636B (en) | 2024-04-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107296636A (en) | A kind of injectable styptic sponge device, syringe and external member | |
| WO2016133483A1 (en) | Hemostatic composition and hemostatic device (variants) | |
| WO2006005939A1 (en) | Vacuum wound dressings | |
| GB2415908A (en) | Vacuum wound dressings | |
| DE102008061535A1 (en) | Medical absorbent body, in particular for the removal of wound fluids from human and / or animal body cavities, and method for its production | |
| CN207654190U (en) | A kind of injectable styptic sponge device, syringe and external member | |
| CN209827804U (en) | Painless injection patch for intravenous infusion | |
| CN108294797B (en) | The manufacturing method of fast hemostasis device | |
| CN209884244U (en) | High-efficient quick hemostasis system | |
| CN205434083U (en) | Wound hemostasis device with function of adding medicine to repeatedly | |
| CN206372091U (en) | A kind of Chinese medicines plug for being used to treat bronchia mucosal bleeding | |
| CN206995306U (en) | A kind of liquid layered peels off anti-wrinkle special equipment | |
| CN206526386U (en) | A kind of soft capsule tampon | |
| CN104873231B (en) | Portable fast hemostatic device | |
| CN103520765B (en) | Method for preparing wound hemostasis dressing | |
| CN211272628U (en) | Suture line capable of absorbing collagen | |
| CN211911977U (en) | Dentistry postoperative hemostasis gauze package | |
| CN206372089U (en) | Emergence fast hemostasis device | |
| CN204134027U (en) | A kind of medicament slow release gynecological underwear | |
| CN202505417U (en) | Hemostasis nose tampon | |
| CN203539536U (en) | Disposable medical hemostasis yarn ball | |
| CN201743822U (en) | Wound wrapping cold and hot compress bag | |
| CN202589784U (en) | Hollow tampon | |
| CN107198574A (en) | A kind of skin dilator and the method for expanding skin | |
| CN210673381U (en) | Novel removable hemostasis of spiral inner core is tied |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |