CN107280684A - Order Scattering focuses on regulation and control blood parameters monitoring device - Google Patents
Order Scattering focuses on regulation and control blood parameters monitoring device Download PDFInfo
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- CN107280684A CN107280684A CN201710595935.2A CN201710595935A CN107280684A CN 107280684 A CN107280684 A CN 107280684A CN 201710595935 A CN201710595935 A CN 201710595935A CN 107280684 A CN107280684 A CN 107280684A
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- 239000008280 blood Substances 0.000 title claims abstract description 42
- 210000004369 blood Anatomy 0.000 title claims abstract description 42
- 230000033228 biological regulation Effects 0.000 title claims abstract description 26
- 238000012806 monitoring device Methods 0.000 title claims abstract description 12
- 238000012544 monitoring process Methods 0.000 claims abstract description 34
- 230000003287 optical effect Effects 0.000 claims abstract description 27
- 230000005693 optoelectronics Effects 0.000 claims abstract description 21
- 238000004458 analytical method Methods 0.000 claims abstract description 17
- 238000012545 processing Methods 0.000 claims abstract description 17
- 238000007405 data analysis Methods 0.000 claims abstract description 7
- 238000006243 chemical reaction Methods 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims abstract description 5
- 230000006641 stabilisation Effects 0.000 claims abstract description 4
- 238000011105 stabilization Methods 0.000 claims abstract description 4
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- 230000003993 interaction Effects 0.000 claims description 4
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- 230000036039 immunity Effects 0.000 abstract description 4
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- 239000008103 glucose Substances 0.000 description 11
- 238000000034 method Methods 0.000 description 10
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- 230000006870 function Effects 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 201000001421 hyperglycemia Diseases 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 208000013016 Hypoglycemia Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
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- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
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Abstract
Regulation and control blood parameters monitoring device is focused on the present invention relates to a kind of Order Scattering, light source driver module driving array of source transmitting different wave length light field, Wave-front phase controller and light field focusing block are disposed with array of source outgoing light field light path, array optical electric transducer is provided with Order Scattering light field emitting light path, array optical electric transducer realizes input system control unit after optoelectronic information conversion by the light field containing monitored material information is detected, Wave-front phase controller, array optical electric transducer, the part of system control component three constitutes dynamic control loop, realize that Order Scattering focuses on regulation and control；System control component is connected with information analysis processing component, and information analysis processing component carries out Data Analysis Services to the optoelectronic information after stabilization and obtains blood parameters achievement data.Detection zone of the present invention is controllable, monitoring accuracy is high, real-time dynamic, uniformity are good, strong interference immunity, high reliability, the features such as applied widely, flexibility is strong, function is easy to expand.
Description
Technical field
The present invention relates to a kind of noninvasive blood parameters monitoring device, particularly it is a kind of be applied to blood test, health control,
The fields such as health monitoring, disease physiotherapy, life science, medical diagnosis, biotechnology, man-machine interaction, behavior tissue, wisdom perception
In a kind of Order Scattering focus on regulation and control blood parameters monitoring device, belong to noninvasive blood parameters monitoring technical field.
Background technology
Noninvasive blood parameters monitoring is examined in blood test, health control, health monitoring, disease physiotherapy, life science, medical treatment
There is Important Academic Research Significance and actual extensively in the fields such as disconnected, biotechnology, man-machine interaction, behavior tissue, wisdom perception
Application value.By taking diabetes as an example, China has become the most country of diabetes mellitus number, is related to about according to the network information
1.2 hundred million crowds.Diabetes are one group of metabolic diseases being characterized with hyperglycaemia, and hyperglycaemia is due to then defect of insulin secretion
Or its biological agent is impaired, or both have concurrently and cause, long-term existence hyperglycaemia may cause various tissues, particularly eye, kidney, the heart
Dirty, blood vessel, the chronic lesion of nerve, dysfunction.Blood glucose target non-invasive monitoring method will greatly promote the finger of hyperglycemic patients
Mark monitoring tracking behavior, improves Consumer's Experience sense and psychological comfort degree, with extensively using value.
There are a variety of noninvasive blood parameters monitoring devices in first technology, see United States Patent (USP), entitled Apparatus for
Non-invasive glucose monitoring, granted patent number is US9662004B2, and the license time is 2017
30 days 05 month, patentee was TaiWan, China bio-photon company（Taiwan Biophotonic Corporation）.Formerly
Technology and product have the advantages that suitable, but it is not enough to there are some essence：1）Detection eye aqueous humor optically-active characteristic is used for inspection
Principle is surveyed, the sugared component content in eye aqueous humor and sugared component content in blood are not same indexs, it is necessary to carry out mapping conversion,
Monitoring accuracy and uniformity receive limitation, there is monitoring error, and be difficult to further improve；2）Eye aqueous humor sugar component content with
The change of sugared component content is not synchronous in blood, and the blood sugar concentration in aqueous humor will postpone compared to Blood Glucose change in concentration
Timely minute, it is difficult to be applicable that this is for the detection that hypoglycemia occurs, and influences the scope of application, and can not dynamically carry out in real time
Blood sugar monitoring；3）Aqueous humor has preceding aqueous humor and aqueous humor, and centre has separated a part by iris, that is to say, that the difference of light forwarding system
The concentration of glucose of aqueous humor, also has before the different concentration of glucose for being likely to result in measuring by the result for causing measurement is likely to be
May be by the glucose in aqueous humor to interference, monitoring uniformity and the degree of accuracy receive influence, it is impossible to realize high uniformity Gao Zhun
Exactness is monitored；4）For protect eyes, only very limited amount of luminous energy is launched into eyes, monitors very flexible, and the scope of application has
Limit, Consumer's Experience sense is weak and function is difficult to expand.
The content of the invention
It is an object of the invention to supervised for the not enough of above-mentioned technology there is provided a kind of Order Scattering focusing regulation and control blood parameters
Device is surveyed, the device has that method is simple, detection zone is controllable, monitoring accuracy is high, real-time dynamic, uniformity are good, anti-interference
By force, high reliability, the features such as applied widely, flexibility is strong, function is easy to expand.
To achieve the above object, the technical scheme is that：A kind of Order Scattering focuses on regulation and control blood parameters monitoring dress
Put, including：Light field focusing block, Wave-front phase controller, array of source, light source driver module, array optical electric transducer, it is
System control unit, information analysis processing component, the array of source are connected with light source driver module, light source driver module driving
Array of source launches different wave length light field, and carries out frequency modulation(PFM) to each wavelength is luminous, realizes that the multi-wavelength of array of source is more
Modulating frequency is exported；Wave-front phase controller and light field focusing block, ripple are disposed with array of source outgoing light field light path
Preceding phase controller carries out Wave-front phase regulation and control to array of source outgoing light field, is radiated at after light field focusing block monitored
Position, makes monitoring position area light be interacted with tested substance, and array is provided with Order Scattering light field emitting light path
Formula photoelectric sensor, array optical electric transducer realizes that optoelectronic information is converted by the light field containing monitored material information is detected
Input system control unit afterwards, system control component is connected with Wave-front phase controller, Wave-front phase controller, array optical
Electric transducer, the part of system control component three constitute dynamic control loop, realize that Order Scattering focuses on regulation and control；System control component
It is connected with information analysis processing component, information analysis processing component carries out Data Analysis Services to the optoelectronic information after stabilization and obtained
Blood parameters achievement data.
Described monitored site is one of arm, palm, leg, neck region.
Described array of source is multi-wavelength diode laser array, multi-wave length illuminating diode array, wide spectrum light
One kind of the light source of source compound narrow band optical filter.
Described array optical electric transducer is the integrated battle array that array photoelectric element and convergence optical system are constituted
Column photoelectric sensor.
The beneficial effects of the invention are as follows：
The present invention is to be based on Order Scattering focusing principle, using light field Wave-front phase control technique, realizes that multi-wavelength light field is focused on,
Irradiation is detected region, and array optical electric transducer carries out optoelectronic information collection, and optoelectronic information is associated with Wave-front phase regulation and control
Dynamic loop is constituted, area to be monitored optical field characteristics can be regulated and controled and area to be monitored dynamic select is realized, to improve light field
Fully interacted with tested substance, information analysis processing component carries out data point to optoelectronic information data of the monitoring after stable
Analysis, obtains noninvasive blood parameters monitoring result.
Compared with prior art, the invention has the characteristics that：
1）First technology and product have the advantages that suitable, but it is not enough to there are some essence, using detection eye aqueous humor optically-active
Characteristic is sugared component content in Cleaning Principle, eye aqueous humor and sugared component content is not same index, it is necessary to carry out in blood
Mapping conversion, monitoring accuracy and uniformity receive limitation, there is monitoring error, and be difficult to further improve.The present invention is based on more
Level scattering focusing principle, using light field Wave-front phase control technique, realizes that multi-wavelength light field is focused on, irradiation is detected region, battle array
Column photoelectric sensor carries out optoelectronic information collection, and information analysis processing component is carried out to optoelectronic information data of the monitoring after stable
Data analysis, obtains noninvasive blood parameters monitoring result, with method is simple, monitoring accuracy is high, real-time monitoring, uniformity it is good,
The features such as strong interference immunity, high reliability；
2）Formerly the eye aqueous humor sugar component content in technology is not synchronous with the change of sugared component content in blood, in aqueous humor
Blood sugar concentration to postpone timely minute compared to Blood Glucose change in concentration, it is difficult suitable that this is for the detection that hypoglycemia occurs
, the scope of application is influenceed, and can not dynamically carry out blood sugar monitoring in real time.The present invention utilizes light field and blood parameters phase interaction
With being monitored, the change of sugared component content and optoelectronic information in square dynamic method carry out dynamic realtime association, optoelectronic information in liquid
Composition dynamic loop is associated with Wave-front phase regulation and control, area to be monitored optical field characteristics can be regulated and controled and realize that area to be monitored is moved
State select, fully interacted with tested substance with improving light field, and only needed to when using by detection means be placed on by
Detection zone, with applied widely, flexibility is strong, function is easy to expansion, applied widely, psychological comfort degree is good, use
The features such as family experience sense is strong；
3）First technology aqueous humor has preceding aqueous humor and aqueous humor, and centre has separated a part by iris, that is to say, that light forwarding system
Difference the concentration of glucose that the result for causing measurement is likely to result in measuring is likely to be before aqueous humor concentration of glucose,
It is also possible to by the glucose in aqueous humor to interference, monitoring uniformity and the degree of accuracy receive influence, it is impossible to realize high uniformity
High accuracy is monitored.The present invention takes full advantage of the noninvasive blood parameters monitoring principle of optoelectronic information, can carry out blood multi-parameter
Dynamic realtime is monitored, with standard boom and modular basis, and Order Scattering focuses on regulation and control, with strong interference immunity, highly reliable
The features such as property, high uniformity；
4）First technology is for protect eyes, and only very limited amount of luminous energy is launched into eyes, monitors very flexible, the scope of application
Limited, Consumer's Experience sense is weak and function is difficult to expand.It is of the invention to be detected on personnel's skin, the portion such as arm, the back of the hand
Point, with it is noninvasive it is painless, using it is flexible, safe the features such as.
Brief description of the drawings
Fig. 1 focuses on regulation and control blood parameters monitoring device schematic diagram for the Order Scattering of the present invention.
Embodiment
The invention is described further with reference to the accompanying drawings and examples.
As shown in figure 1, the Order Scattering of the present invention focuses on regulation and control blood parameters monitoring device, including：Light field focusing block
2nd, Wave-front phase controller 3, array of source 4, light source driver module 5, array optical electric transducer 6, system control component 7, letter
Breath analyzing and processing part 8.
Array of source 4 is connected with light source driver module 5, the driving transmitting different wave length of array of source 4 of light source driver module 5
Light field, and frequency modulation(PFM) is carried out to each wavelength is luminous, realize many modulating frequency outputs of multi-wavelength of array of source 4；Light source battle array
Wave-front phase controller 3 and light field focusing block 2,3 pairs of light of Wave-front phase controller are disposed with the outgoing light field light path of row 4
The outgoing light field of source array 4 carries out Wave-front phase regulation and control, and monitored site 1 is radiated at after light field focusing block 2；Monitor position
1 region light field is interacted with tested substance, and array optical electric transducer 6 is provided with Order Scattering light field emitting light path,
Array optical electric transducer 6 realizes input system control after optoelectronic information conversion by the light field containing monitored material information is detected
Part 7 processed, system control component 7 is connected with Wave-front phase controller 3, Wave-front phase controller 3, array optical electric transducer
6th, the part of system control component 7 three constitutes dynamic control loop, realizes that Order Scattering focuses on regulation and control；System control component 7 with
Optoelectronic information after information analysis processing component 8,8 pairs of stabilizations of information analysis processing component carries out Data Analysis Services and obtains blood
Parameter index data.
In the present embodiment, monitored site 1 is inboard arm；Array of source 4 is multi-wavelength diode laser array, altogether
In the presence of four wavelength, 2 are visible light wave range wavelength, and 2 are infrared band wavelength；Array optical electric transducer 6 uses CMOS
Area array sensor array；System control component 7 adds DSP architecture using FPGA；Information analysis processing component 8 uses FPGA frameworks.
The present embodiment course of work is：The driving transmitting different wave length light field of array of source 4 of light source driver module 5, and to every
Individual wavelength is luminous to carry out frequency modulation(PFM), realizes many modulating frequency outputs of multi-wavelength of array of source 4；3 pairs of Wave-front phase controller
The outgoing light field of array of source 4 carries out Wave-front phase regulation and control, and monitored site 1 is radiated at after light field focusing block 2；Monitoring portion
1 region light field of position is interacted with tested substance, and array optical electric transducer is provided with Order Scattering light field emitting light path
6, array optical electric transducer 6 will detect the light field containing monitored material information and realize input system after optoelectronic information conversion
Control unit 7, Wave-front phase controller 3, array optical electric transducer 6, system control component 7 together constitute dynamic control and returned
Road, realizes that Order Scattering focuses on regulation and control；System control component 7 and information analysis processing component 8,8 pairs of information analysis processing component
Optoelectronic information after stable carries out Data Analysis Services and obtains blood parameters achievement data.The present embodiment is successfully realized in blood
The multi-parameter monitoring of blood oxygen, blood glucose, overcomes present technical deficiency.
Mechanical structure, SECO, module construction, signal transmission, Wave-front phase regulation and control device etc. are into the present invention
Cooking technique, inventive point of the invention is to be based on Order Scattering focusing principle, using light field Wave-front phase control technique, realizes many
Wavelength light field is focused on, and array optical electric transducer carries out optoelectronic information collection, and optoelectronic information is associated into structure with Wave-front phase regulation and control
Into dynamic loop, area to be monitored optical field characteristics can be regulated and controled and area to be monitored dynamic select is realized, information analysis processing
Part carries out data analysis to optoelectronic information data of the monitoring after stable, obtains noninvasive blood parameters monitoring result, provides method
Simply, monitoring accuracy height, dynamic monitoring, good uniformity, strong interference immunity, high reliability, applied widely, flexibility be strong, work(
A kind of noninvasive blood parameters monitoring method expanded is readily susceptible to, the deficiency of first technology is substantially avoided.
The technical scheme and beneficial effect of the invention are described in detail above-described embodiment,
It should be understood that the foregoing is only presently most preferred embodiment of the invention, it is not intended to limit the invention, all originals in the present invention
Any modification, supplement and equivalent substitution for being made in the range of then etc., should be included in the scope of the protection.
Claims (4)
1. a kind of Order Scattering focuses on regulation and control blood parameters monitoring device, including：Light field focusing block（2）, Wave-front phase control
Device（3）, array of source（4）, light source driver module（5）, array optical electric transducer（6）, system control component（7）, information point
Analyse processing component（8）, it is characterised in that：The array of source（4）With light source driver module（5）It is connected, light source driver module
（5）Drive array of source（4）Launch different wave length light field, and frequency modulation(PFM) is carried out to each wavelength is luminous, realize array of source
（4）The output of multi-wavelength many modulating frequencies；Array of source（4）Wave-front phase controller is disposed with outgoing light field light path
（3）With light field focusing block（2）, Wave-front phase controller（3）To array of source（4）Outgoing light field carries out Wave-front phase regulation and control,
By light field focusing block（2）After be radiated at monitored site（1）, make monitoring position（1）Region light field and tested substance phase
Array optical electric transducer is provided with interaction, Order Scattering light field emitting light path（6）, array optical electric transducer（6）Will
Detect the light field containing monitored material information and realize input system control unit after optoelectronic information conversion（7）, system control
Part（7）With Wave-front phase controller（3）It is connected, Wave-front phase controller（3）, array optical electric transducer（6）, system control
Part processed（7）Three parts constitute dynamic control loop, realize that Order Scattering focuses on regulation and control；System control component（7）With information point
Analyse processing component（8）Connection, information analysis processing component（8）Data Analysis Services are carried out to the optoelectronic information after stabilization and obtain blood
Liquid parameter index data.
2. Order Scattering according to claim 1 focuses on regulation and control blood parameters monitoring device, it is characterised in that：Described quilt
Monitor position（1）For one of arm, palm, leg, neck region.
3. Order Scattering according to claim 1 focuses on regulation and control blood parameters monitoring device, it is characterised in that：Described light
Source array（4）Filtered for multi-wavelength diode laser array, multi-wave length illuminating diode array, broad spectrum light source compound narrow band
One kind of the light source of piece.
4. Order Scattering according to claim 1 focuses on regulation and control blood parameters monitoring device, it is characterised in that：Described battle array
Column photoelectric sensor（6）The integrated array formula photoelectric sensing constituted for array photoelectric element and convergence optical system
Device.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108261286A (en) * | 2017-11-29 | 2018-07-10 | 北京华夏光谷光电科技有限公司 | A kind of lossless blood sugar test and the multiplexing earmuff of the laser acupuncture ear acupuncture point |
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| EP3076861B1 (en) * | 2014-09-09 | 2017-12-20 | Koninklijke Philips N.V. | Vital signs monitoring system |
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| CN101264019A (en) * | 2007-03-16 | 2008-09-17 | 北京中科光睿科技有限责任公司 | Novel portable non-invasive, continuous, real time blood sugar monitoring instrument based on light sound technique |
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