CN107261324A - Egersimeter system with charge function - Google Patents
Egersimeter system with charge function Download PDFInfo
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- CN107261324A CN107261324A CN201710554053.1A CN201710554053A CN107261324A CN 107261324 A CN107261324 A CN 107261324A CN 201710554053 A CN201710554053 A CN 201710554053A CN 107261324 A CN107261324 A CN 107261324A
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- egersimeter
- charge function
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/37—Monitoring; Protecting
- A61N1/3702—Physiological parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/378—Electrical supply
- A61N1/3787—Electrical supply from an external energy source
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Gastroenterology & Hepatology (AREA)
- Electrotherapy Devices (AREA)
Abstract
The present invention relates to a kind of egersimeter system with charge function, including vivo system and vitro system;Vivo system includes stimulating unit, at least one pair of stimulating electrode, perception unit, at least one pair of sensing electrode and one group of sensor, internal charhing unit, internal communication unit, signal and stored and processing unit, control and voltage conversion unit;Vitro system includes charger and processor.The present invention is a kind of full-implantation type, can realize high-energy stimulate with the electric stimulation of wireless charging, available for strengthening the convergent force of big internal organs official, such as heart and stomach;Present invention could apply to the diseases such as chronic heart failure, obesity and diabetes B.
Description
Technical field
The present invention relates to a kind of egersimeter system, and in particular to a kind of carrying charge function, is received for lifting organ
The egersimeter system of contracting power.
Background technology
Chronic heart failure is angiocardiopathy " final home to return to ", is a kind of malignant disease of high mortality, 40%
Patient is dead in 12 months, and 65% patient is dead in 60 months.Moreover, the patient of chronic heart failure is all
Quality of life is worst in chronic.In shrinkage Patients with Chronic Heart Failure, 30% belongs to the wide colony of QRS wave, to this portion
Divide patient, CRT (cardiac resynchronization device, Cardiac Resynchronization Therapy, CRT) can be implanted into.Remaining
70% patient, has no medicine evident in efficacy with administering apparatus at present.
Diabetes B is a kind of lifelong disease.Once it is ill, need medical treatment throughout one's life.According to《Type 2 Diabetes In China preventing and treating refers to
South 2013》, China's diabetic's population is more than 100,000,000, it has also become the most country of diabetes number of patients in the world.Meanwhile,
The obesity size of population of China was exponentially increased sharply in past 15 years.According to data of the South China Morning Post quoted from The Lancet, cut
Only the end of the year 2013, Chinese population of being obese is 62,000,000 people.Worldwide, to have more than 60% in diabetes B patient same
When belong to obese people.
The existing CRT equipment for chronic heart failure, is not suitable for the narrow crowd of QRS wave.And it is all at present for fertilizer
Fat electrical stimulating therapy, is all not enough to produce the electro photoluminescence of high energy.There are some researches prove in myocardium refractory period release high energy electricity thorn
Swash, cardiac contractile force can be strengthened, so that reaching improves the purpose of heart failure;It is another that there are some researches prove release in stomach muscle refractory period
High-energy electrical stimulation is put, stomach convergent force can be strengthened, so as to influence gastric bulgy lesion, and then brain centres are acted on, to reach bar
The function of part blood sugar for human body secretion.
Therefore, it is badly in need of a kind of high energy that can regulate and control organ convergent force, chargeable egersimeter system, it is chronic for treating
Heart failure, obesity are with diseases such as diabetes Bs.
The content of the invention
Present invention aims at provide a kind of egersimeter system with charge function.
The technical scheme for realizing the object of the invention is:A kind of egersimeter system with charge function, including system in vivo
System and vitro system;
Vivo system includes:
Stimulating unit, current source or stimulation voltage source for producing electro photoluminescence;
At least one pair of stimulating electrode, for electrical stimulation signal to be applied into target organ;
Unit is perceived, the information for being gathered to sensor is adaptively amplified;
At least one pair of sensing electrode, the electrical activity for gathering organ surface;
Sensor, including be fixed on stimulator housing, for perceiving the acceierometer sensor of human action and consolidating
It is scheduled on sensing electrode wire, for the muscular movement of perceptual organ surface or the pressure sensor of organ internal flow;
Internal charhing unit, for being powered for vivo system;
Internal communication unit, for being communicated with vitro system;
Signal is stored and processing unit, the human body physiological data collected for storage electrode, and according to different applications
Produce different stimulations;
Control and voltage conversion unit, voltage needed for for converting battery voltage to system work, and control whole body
Interior system operating;
Vitro system includes:
Charger, for being charged to internal charhing unit, and obtain in vivo charging relevant information, by these information with
Processor is communicated;
Processor, internal signal storage and processing unit are write for the input of adjustable parameter, and by wireless telecommunications;
Meanwhile, read the information of vivo system storage.
Compared with prior art, remarkable advantage of the invention is:
The present invention is a kind of full-implantation type, can be applied to chronic heart failure, treatment obesity, 2 type glycosurias
The electric stimulation of the diseases such as disease;
Myocardial contractive power, chronic heart failure (QRS wave is narrow) are adjusted by high-energy electrical stimulation;The present invention is by the heart
Flesh absolute refractory period, carries out non-excitability electro photoluminescence, to strengthen the intensity of ventricular contraction and the pumpability of heart;Patient is implanted into
After the equipment, cardiac ejection ability and heart are taken the photograph oxygen peak amount and can increased, and admission rate and the death rate can decline to a great extent.Outside the equipment
See and be similar to pacemaker, implantation position is in human body sublavian;Doctor can be implanted into by Minimally Invasive Surgery, be furnished with fill in vitro
Electric equipment, charging in about one week is once.
Satiety is produced by constant low energy electro photoluminescence and high-energy electrical stimulation adjusts stomach muscular contraction force, to treat obesity
Based on, and treat diabetes B;The present invention strengthens stomach by carrying out non-excitability electro photoluminescence in stomach muscle absolute refractory period
The intensity of contraction, meanwhile, long-term low energy stimulation is carried out to stomach muscle or gastric bulgy lesion;Outward appearance is similar to cardiac pacing
Device, implantation position is in human abdomen.Doctor can be implanted into by laparoscopic surgery, in vitro equipped with charging equipment, be charged within about one week
Once.
Brief description of the drawings
Fig. 1 is the egersimeter systematic schematic diagram with charge function of the present invention.
Fig. 2 is the application block diagram of the present invention.
Fig. 3 is monophasic pulses if schematic diagram.
Fig. 4 is amplitude, the boost pulse schematic diagram of adjustable pulse width.
Fig. 5 is train of pulse schematic diagram.
Fig. 6 is diphasic pulse schematic diagram.
Embodiment
With reference to Fig. 1, Fig. 2, a kind of egersimeter system with charge function, including vivo system and vitro system;
Vivo system includes:
Stimulating unit, current source or stimulation voltage source for producing electro photoluminescence;
At least one pair of stimulating electrode, for electrical stimulation signal to be applied into target organ;
Unit is perceived, the information for being gathered to sensor is adaptively amplified;
At least one pair of sensing electrode, the electrical activity for gathering organ surface;
Sensor, including be fixed on stimulator housing, for perceiving the acceierometer sensor of human action and consolidating
It is scheduled on sensing electrode wire, for the muscular movement of perceptual organ surface or the pressure sensor of organ internal flow;
Internal charhing unit, for being powered for vivo system;
Internal communication unit, for being communicated with vitro system;
Signal is stored and processing unit, the human body physiological data collected for storage electrode, and according to different applications
Produce different stimulations;
Control and voltage conversion unit, voltage needed for for converting battery voltage to system work, and control whole body
Interior system operating;
Vitro system includes:
Charger, for being charged to internal charhing unit, and obtain in vivo charging relevant information, by these information with
Processor is communicated;
Processor, internal signal storage and processing unit are write for the input of adjustable parameter, and by wireless telecommunications;
Meanwhile, read the information of vivo system storage.
Further, the unit that perceives has 100-1200 times of adaptive adjustable amplification range.
Further, the system is configured to apply heart voltage source, sensor for human detection's action and heart
Interior blood stream pressure.
Further, the system is configured to apply stomach current source, sensor detection stomach muscle motion, and judgement is
It is no on the feed.
Further, the internal charhing unit also includes temperature control modules, for monitoring internal charhing unit temperature
And charging rate.Charging rate is at least 75mA/h, and the heating of implant surrounding tissue is no more than 2 degrees Celsius.Charging is single in vivo
The capacity of member is in 100-400mAh.
Further, the processor includes signal transacting and display unit, control and input block, external communication unit
With storage and uploading unit;
Signal transacting is used to perceive the information stored in vivo with display unit and stimulus information is handled and shown;
Control is used for the input of adjustable parameter with input block;
External communication unit is used to communicate with internal communication unit;
Store is used to store the information collected and uploads onto the server with uploading unit.
Further, the communication modes of the internal communication unit are near-field communication, radio-frequency communication or bluetooth communication.
Further, the charger includes charhing unit and communication unit, is respectively used to charge and obtains and charges in vivo
Unit information.
The stimulus waveform scope that stimulating unit of the present invention is produced is as follows:
Monophasic pulses if:It is single-phase to refer to boost pulse only one of which phase, as shown in Figure 3.
The specific data of following monophasic pulses if:
Galvanism amplitude | 0~19mA |
Voltage stimulation amplitude | 1.94~10.69V |
Stimulate pulsewidth | 50us~100ms |
Frequency of stimulation | 1~500Hz |
Amplitude, the pulsewidth of boost pulse are adjustable, as shown in Figure 4.
Using burst form, frequency of stimulation 1-1000Hz, as shown in Figure 5.
Diphasic pulse:Two-phase refers to that boost pulse has two phases, Symmetrical, as shown in Figure 6.
With reference to embodiment, the present invention is described in detail.
Embodiment 1
The electric stimulation of the present embodiment is used as in myocardium refractory period, using high-energy electrical stimulation chronic heart failure;
Egersimeter system includes being located at internal implant stimulator, electrode, and positioned at external processor and fills
Electrical equipment;
Implant stimulator includes:
Stimulating unit, for producing stimulation voltage source;
One group be placed in atrium dextrum bipolar pacemaker electrode, for detecting electrocardiosignal;
One group or two groups be placed in right ventricle bipolar pacemaker electrode, for detect electrocardiosignal and produce high energy electricity thorn
Swash;
Sensor, including be fixed on stimulator housing, for perceiving the acceierometer sensor of human action and consolidating
It is scheduled on target organ, for the muscular movement of perceptual organ surface or the pressure sensor of organ internal flow;
Unit is perceived, the information for being gathered to sensor is adaptively amplified;
Internal charhing unit, for being powered for vivo system;
Internal communication unit, for being communicated with vitro system;
Signal is stored and processing unit, the human body physiological data collected for storage electrode, and according to different applications
Produce different stimulations;
Control and voltage conversion unit, voltage needed for for converting battery voltage to system work, and control whole body
Interior system operating;
External charger is used to charge to internal charhing unit, and obtains charging relevant information in vivo, by these
Information is communicated with processor;
External processor is used for the input of adjustable parameter, and writes internal signal storage with handling by wireless telecommunications
Unit;Meanwhile, read the information of vivo system storage.
High-energy electrical stimulation is the set of pulses string being made up of diphasic pulse;Include 3-10 per group pulse string to diphasic pulse;
Diphasic pulse amplitude is about 5-10V, and amplitude adjustment is not more than 0.5V;
Implant stimulates path to include 1-2 roads voltage source;
Being implanted into bulk measurement path includes 1-2 roads measuring circuit, and a/d resolution is more than or equal to 12bit, sample rate 1kHz;Measurement
Circuit multiplication factor 100-1200 is adjustable, and filter cutoff frequency 0.05-100Hz is adjustable;
The monitoring and stimulating method:Detected in detection path when myocardium refractory period is produced (when QRS wave starts), thorn
Sharp path starts to produce one group of high energy pulse string (acting on right ventricle).Normal electrocardio-activity had not both been interfered with so, and not
Ventricular arrhythmia can be induced.Can be set by processor monitors refractory period with stimulating the time delay started.But ensure
Stimulation is provided in refractory period to be finished.One typical electro photoluminescence is one group of 6 pulse (duration about 30ms), diphasic pulse
7.5 volts of amplitude.
Embodiment 2
The electric stimulation of the present embodiment is a kind of implantation type electric stimulation system for treating obesity and type-II diabetes treatment
System.
Egersimeter system includes being located at internal implant stimulator, electrode, and positioned at external processor and fills
Electrical equipment;
Implant stimulator includes:
Stimulating unit, for producing stimulating current source;
The one group or two groups bipolar divergent electrode as antrum, for detecting gastric slow wave signal, and discharges high-energy stimulation
And/or low energy is stimulated;
One as stomach close to esophagus position 3-dimensional dynamic pickup, by detecting that muscle relative position at the top of stomach becomes
Change to detect feed event;
It is fixed on stimulator housing, the acceierometer sensor for perceiving human action;
Unit is perceived, the information for being gathered to sensor is adaptively amplified;
Internal charhing unit, for being powered for vivo system;
Internal communication unit, for being communicated with vitro system;
Signal is stored and processing unit, the human body physiological data collected for storage electrode, and according to different applications
Produce different stimulations;
Control and voltage conversion unit, voltage needed for for converting battery voltage to system work, and control whole body
Interior system operating;
Being placed in external charger is used to charge to internal charhing unit, and obtains charging relevant information in vivo, will
These information are communicated with processor;
Being placed in external processor is used for the input of adjustable parameter, and by wireless telecommunications write internal signal storage with
Processing unit;Meanwhile, read the information of vivo system storage.
Treatment method:When detecting feed event, high energy overlap biphasic impulse is produced;Usually produce low energy monophasic pulses if string
Stimulate.
High energy/feed part:
The high-energy electrical stimulation is the set of pulses string being made up of diphasic pulse;Include 3-10 per group pulse string to two-phase arteries and veins
Punching;Diphasic pulse amplitude is about 5-15mA, and amplitude adjustment is not more than 0.6mA;
Implant stimulates path to include 1-4 roads current source;
Being implanted into bulk measurement path includes 1-4 roads measuring circuit, and a/d resolution is more than or equal to 12bit, sample rate 1kHz;Measurement
Circuit multiplication factor 100-1200 is adjustable, and filter cutoff frequency 0.05-100Hz is adjustable;
The monitoring of the present embodiment and stimulating method:When detection path detects stomach smooth muscle flesh refractory period and produced
(rising stage of gastric slow wave), path is stimulated to start to produce one group of high energy pulse string.Normal gastric electrical activity will not so be interrupted.Can
Monitor refractory period with stimulating the time delay started to be set by processor.But ensure to stimulate and provided in refractory period
Finish.One typical electro photoluminescence is one group of 5-10 pulse, diphasic pulse amplitude 7.5mA.The effect being finally reached is exactly stomach
Slow wave amplitude is enhanced by artificial, adds the convergent force of stomach.
Monitoring is only triggered with stimulating method after sensor detects feed event above.Once being triggered, it will tie up
Hold the enhancing stimulation of the duration stomach convergent force of 60-90 minutes.
The part of low energy/usually:
Usually, stomach maintains the monophasic pulses if string that a pulsewidth is more than 1ms, and its stimulation rate is 30-100Hz, stimulates width
Spend for 5-10mA, this is stimulated for suppressing WeiDongLi Capsule, and stimulating will maintain 2s to stimulate, and 2s stops.One typical electro photoluminescence is
Pulsewidth is 3-5ms, and stimulation rate is 50Hz, and stimulation amplitude is 6mA.
Claims (9)
1. a kind of egersimeter system with charge function, it is characterised in that including vivo system and vitro system;
Vivo system includes:
Stimulating unit, current source or stimulation voltage source for producing electro photoluminescence;
At least one pair of stimulating electrode, for electrical stimulation signal to be applied into target organ;
Unit is perceived, the information for being gathered to sensor is adaptively amplified;
At least one pair of sensing electrode, the electrical activity for gathering organ surface;
Sensor, including be fixed on stimulator housing, for perceiving the acceierometer sensor of human action and being fixed on
On sensing electrode wire, for the muscular movement of perceptual organ surface or the pressure sensor of organ internal flow;
Internal charhing unit, for being powered for vivo system;
Internal communication unit, for being communicated with vitro system;
Signal is stored and processing unit, the human body physiological data collected for storage electrode, and is produced according to different applications
Different stimulations;
Control and voltage conversion unit, voltage needed for for converting battery voltage to system work, and control whole system in vivo
System operating;
Vitro system includes:
Charger, for being charged to internal charhing unit, and obtains charging relevant information in vivo, by these information and processing
Device is communicated;
Processor, internal signal storage and processing unit are write for the input of adjustable parameter, and by wireless telecommunications;Together
When, read the information of vivo system storage.
2. the egersimeter system according to claim 1 with charge function, it is characterised in that the perception unit tool
There is 100-1200 times of adaptive adjustable amplification range.
3. the egersimeter system according to claim 1 with charge function, it is characterised in that the system is configured
To apply blood stream pressure in voltage source, sensor for human detection's action and heart to heart.
4. the egersimeter system according to claim 1 with charge function, it is characterised in that the system is configured
To apply current source to stomach, sensor detection stomach muscle motion judges whether on the feed.
5. the egersimeter system according to claim 1 with charge function, it is characterised in that the internal charging is single
Member also includes temperature control modules, for monitoring internal charhing unit temperature and charging rate.
6. the egersimeter system according to claim 5 with charge function, it is characterised in that the charging rate is extremely
It is 75mA/h less, and the heating of implant surrounding tissue is no more than 2 degrees Celsius during charging.
7. the egersimeter system according to claim 1 with charge function, it is characterised in that the processor includes
Signal transacting and display unit, control and input block, external communication unit and storage and uploading unit;
Signal transacting is used to perceive the information stored in vivo with display unit and stimulus information is handled and shown;
Control is used for the input of adjustable parameter with input block;
External communication unit is used to communicate with internal communication unit;
Store is used to store the information collected and uploads onto the server with uploading unit.
8. the egersimeter system according to claim 1 with charge function, it is characterised in that the internal communication is single
The communication modes of member are near-field communication, radio-frequency communication or bluetooth communication.
9. the egersimeter system according to claim 1 with charge function, it is characterised in that the charger includes
Charhing unit and communication unit, are respectively used to charge and obtain internal charhing unit information.
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CN201710554053.1A CN107261324A (en) | 2017-07-09 | 2017-07-09 | Egersimeter system with charge function |
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CN201710554053.1A CN107261324A (en) | 2017-07-09 | 2017-07-09 | Egersimeter system with charge function |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111870810A (en) * | 2020-07-08 | 2020-11-03 | 武汉大学 | Carotid sinus baroreceptor stimulation device |
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CN102500057A (en) * | 2011-09-28 | 2012-06-20 | 上海交通大学 | Multifunctional implanted gastrointestinal electrical stimulation system |
CN102872533A (en) * | 2012-09-11 | 2013-01-16 | 上海市东方医院 | Muscle restoration system for paralyzed limbs |
CN104968392A (en) * | 2012-12-21 | 2015-10-07 | 拜克比特医疗公司 | Methods and systems for lowering blood pressure through reduction of ventricle filling |
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2017
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CN101578067A (en) * | 2005-10-14 | 2009-11-11 | 内诺斯蒂姆股份有限公司 | Leadless cardiac pacemaker and system |
CN1874048A (en) * | 2006-04-28 | 2006-12-06 | 清华大学 | Wireless charging device through skin in use for implantation type medical treatment instrument |
CN102500057A (en) * | 2011-09-28 | 2012-06-20 | 上海交通大学 | Multifunctional implanted gastrointestinal electrical stimulation system |
CN102872533A (en) * | 2012-09-11 | 2013-01-16 | 上海市东方医院 | Muscle restoration system for paralyzed limbs |
CN104968392A (en) * | 2012-12-21 | 2015-10-07 | 拜克比特医疗公司 | Methods and systems for lowering blood pressure through reduction of ventricle filling |
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CN111870810A (en) * | 2020-07-08 | 2020-11-03 | 武汉大学 | Carotid sinus baroreceptor stimulation device |
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Effective date of registration: 20190326 Address after: 215123 Unit E226, North Block, A1 Building, 218 Xinghu Street, Suzhou Industrial Park, Jiangsu Province Applicant after: Suzhou undouble Medical Equipment Co., Ltd. Address before: Room 502, Unit 2, Building 12-1, Chaoyang East Road, Xinpu District, Lianyungang City, Jiangsu Province Applicant before: Ping Lichuan |
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