CN107252381B - A kind of cooling device of Myocardium protecting device - Google Patents
A kind of cooling device of Myocardium protecting device Download PDFInfo
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- CN107252381B CN107252381B CN201710407542.4A CN201710407542A CN107252381B CN 107252381 B CN107252381 B CN 107252381B CN 201710407542 A CN201710407542 A CN 201710407542A CN 107252381 B CN107252381 B CN 107252381B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
- A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Thermal Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of cooling devices of Myocardium protecting device.The cooling device includes blood cooling line；The blood cooling line is cooled down using cooling thing；The cooling thing is cryosel aqueous mixtures；The temperature of the cryosel aqueous mixtures is 18 DEG C~21 DEG C；In the cryosel aqueous mixtures, the mass-volume concentration of salt is 280~320g/L；The cooling thing is set in constant temperature freezer.The present invention by change cooling thing solve be forced extend length of pipe by increase priming volume so that increase resistance the technical issues of, using cryosel aqueous mixtures as cooling thing, its easily prepared and preservation and ingredient safety, since cooling thing temperature reduces very much, the problem of alternating temperature efficiency will greatly reinforce, priming volume and resistance is also just readily solved.
Description
Technical field
The present invention relates to a kind of cooling devices of Myocardium protecting device, belong to the field of medical instrument technology.
Background technology
The purpose of any openheart surgery is provided to reinforce or maintain cardiac function.For this purpose, first, outside heart
Section doctor must avoid forcing at more unnecessary damages of heart, this needs a comprehensive myocardial preservation strategy to instruct
It is preoperative, in myocardial ischemia and the processing in ischemic later stage.It is in office that when the phase there is no enough myocardial preservations will all balance out this
The effort that other stages are done during one, so as to cause myocardial damage and long-term insufficiency (permanent
dysfunction).Since patients are gradually aging, once referring to Zheng high-risk patient without operation, very the minister of public works in ancient china has been shown in now
It is used, keep myocardial preservation strategy more complicated.In addition, all openheart surgeries may all be a challenge, need surgeon continuous
Correct common Preservation tactics.Therefore, it is necessary to the principles to obtainable technology and its behind to understand there are one comprehensively thorough,
To provide most suitable myocardial preservation under surgical state for each patient.
From the fifties in last century, make heart reach electromechanical to stop shape of fighting using cardioplegic solution in department of cardiovascular surgery art
State not only can get clearly visual area, be conducive to patient's operation, it is often more important that can mitigate Myocardial Ischemia Reperfusion Injury.This
Afterwards, cardioplegic solution always is the hot spot of research with myocardial ischemia-reperfusion injury.Currently, cardioplegic solution has been developed to
More than 800 kinds, and as most common important one of myocardial preservation measure in cardiovascular surgical procedure.
The energy expenditure of heart is mainly made of the metabolism three parts of mechanical work, maintenance wall tension and cardiac muscle cell,
The above two account for about 90%, and the latter accounts for about 10%.Cardioplegic solution can be such that cardiac muscle is stoped jumping in diastole, and electromechanical activity stops, because
This, during cardiac arrest, cardiac energy consumes the metabolism for being entirely used for cardiac muscle cell, and most directly effect is to reduce to low temperature
The energetic supersession of cardiac muscle cell, it was reported that by Myocardial temperature from when being down to 11 DEG C for 37 DEG C, metabolism of myocardium oxygen consumption can be by
10% is reduced to 5%.
Department of cardiovascular surgery is at the early-stage soon, and cryogenic technique just starts to be applied in cardiovascular surgical procedure, has become
One of most common methods of myocardial protection, method are discontinuous infusion cold cardioplegic solutions (4 DEG C) in right amount, at the same by ice bits or ice physiology salt
Water, which is placed in cavum pericardiale, makes Heart temperature reduce.Currently, 4~10 DEG C of low temperature is the head that cardioplegic solution is perfused in most departments of cardiovascular surgery
Select temperature.Low temperature mainly has the benefit for the cardiac muscle that stops fighting：1. reducing metabolic rate and oxygen consumption of the cardiac muscular tissue during ischemic, prolong
Long myocardial ischemia tolerance time；2. inhibiting electromechanical activity of the cardiac muscle cell during ischemic；3. slowing down damaged myocardium cell
Necrosis and apoptotic process；4. allowing the discontinuous infusion cardioplegic solution during cardiac muscle stops jumping under cryogenic conditions, it is possible to provide clear bloodless
Visual area operates convenient for patient.Therefore, cryocardioplegic solution as to cardiac muscle important safeguard measure in cardiovascular surgical procedure
In it is commonly used, protecting effect is affirmed by a large amount of experiment and clinical practice.
Invention content
The object of the present invention is to provide a kind of cooling device of Myocardium protecting device, the present invention is made using cryosel aqueous mixtures
For cooling thing, easily prepared and preservation and ingredient safety；It is mixed compared with ice water due to reachable -20 DEG C of the temperature of cryosel aqueous mixtures
Closing object temperature reduces very much, and alternating temperature efficiency will greatly reinforce, and solves in the prior art by extending length of pipe to reach drop
Priming volume and the problem of resistance caused by temperature scale standard.
The cooling device of Myocardium protecting device provided by the present invention, including blood cooling line；
The blood cooling line is cooled down using cooling thing；
The cooling thing is cryosel aqueous mixtures.
In the cooling device, the temperature of the cryosel aqueous mixtures can be -18 DEG C~-21 DEG C.
In the cooling device, in the cryosel aqueous mixtures, the mass-volume concentration of salt can be 280~320g/L.
In the cooling device, the cooling thing is set in constant temperature freezer to get to ice salt bath, when wherein salt
Mass-volume concentration when reaching 280~320g/L, when such as reaching 290g/L, its temperature can be made to reach -20 DEG C, temperature reduces very
It is more, alternating temperature efficiency can be reinforced.
In the cooling device, the cooling device further includes temperature automatically controlled jacking system；
The temperature automatically controlled jacking system includes temp measuring system and control system, and it is cold that the temp measuring system monitors the blood
But the temperature of pipeline, and the temperature signal detected is transferred to the control system；The control system is according to the temperature
Signal adjusts the position relationship between the blood cooling line and the cooling thing, i.e., lifts the blood by lifting gear
Cooling line needs to be detached from the blood cooling line by lifting gear described cold that is, when temperature is less than set temperature
But it in object, when temperature is higher than set temperature, needs to immerse the blood cooling line to the cooling by lifting gear
In object, so that the fluid in the blood cooling line keeps suitable low temperature.
In the cooling device, the thermometric tradition can be infrared temperature measurement system or thermocouple temperature measurement system.
In order to improve the effect of myocardial preservation, existing method is the improvement for pipeline or temperature change material, in order to reach
Certain alternating temperature efficiency have to be forced to extend length of pipe, thus increase priming volume and increase resistance；The alternating temperature taken
Mode is the change warm water of 2 DEG C of water-ice or temperature changing water bank nothing but, be there is a problem of ineffective or expensive.The present invention is by changing
Become cooling thing and solve the above problem, using cryosel aqueous mixtures as cooling thing, easily prepared and preservation and ingredient peace
Entirely, much due to the reduction of cooling thing temperature, the problem of alternating temperature efficiency will greatly reinforce, priming volume and resistance is also just readily solved.
Description of the drawings
Fig. 1 is the schematic diagram of the cooling device fast cooling of Myocardium protecting device of the present invention.
Specific implementation mode
Experimental method used in following embodiments is conventional method unless otherwise specified.
The materials, reagents and the like used in the following examples is commercially available unless otherwise specified.
As shown in Figure 1, the principle signal of fast cooling is carried out to blood for the cooling device of Myocardium protecting device of the present invention
Figure.Cooling device of the present invention includes blood cooling line, is cooled down to the blood cooling line using cryosel aqueous mixtures, will
Cryosel aqueous mixtures are positioned in constant temperature refrigerator, and ice salt bath can be obtained, i.e., are carried out to blood cooling line using ice salt bath
It is cooling, and then heart-lung machine is made to export blood or cold through the blood with the mixture flow of crystal (i.e. the crystal block section of blood cardioplegia)
But it is cooled when pipeline.When the mass-volume concentration of salt in cryosel aqueous mixtures is 290g/L, can be reached by constant temperature refrigerator-
20 DEG C of low temperature can reinforce alternating temperature efficiency.In order to so that the fluid in blood cooling line keeps suitable low temperature, the present invention
Temperature automatically controlled jacking system is also set up, it includes infrared or thermocouple temperature measurement system and control system (such as computer terminal), infrared
Or the temperature of thermocouple temperature measurement system monitoring blood cooling tube, and the temperature signal detected is transmitted in control system, it controls
System is worked as according to the position relationship in the temperature signal adjustment constant temperature refrigerator received between blood cooling line and cooling thing
It when temperature is less than set temperature, needs that blood cooling line is detached from cooling thing by lifting gear, when temperature is higher than setting temperature
When spending, need to immerse blood cooling line into cooling thing to reduce the temperature of blood cooling line by lifting gear.
The cooling effect for the cryosel aqueous mixtures that the present invention uses is investigated, wherein Cold crystalloid uses thomas' fluid.
According to the Crystalloid cardioplegia (flow 300ml/min) of 2L, 25 DEG C are cooled to the time required to 10 DEG C (it is generally acknowledged that
It is satisfactory within ten minutes), evaluate the cooling effect of each cooling medium：
1) perfusion device (An Zhen type) is stoped jumping using disposable crystal to be irrigated；
It is used as medium that can only cool to 18 DEG C for (0 DEG C) using common mixture of ice and water；
Using -20 DEG C of cryosel aqueous mixtures of the present invention 10 points are needed as medium 30 seconds.
2) perfusion device (abundant external form) is stoped jumping using disposable crystal to be irrigated；
Using common mixture of ice and water 10 minutes are needed as medium；
Using -20 DEG C of cryosel aqueous mixtures of the present invention 6 points are needed as medium 30 seconds.
3) perfusion device (prestige is high) is stoped jumping using disposable crystal to be irrigated；
It needs to make for 10 minutes to stop jumping liquid with 2 DEG C of water coolings and drops to 14 DEG C.
4) disposable crystal is stoped jumping into perfusion device (abundant external form) and becomes isothermal segment shortening half；
Using -20 DEG C of cryosel aqueous mixtures of the present invention 8 points are needed as medium 30 seconds；
As can be seen that becoming isothermal segment shortens half, priming volume is reduced, but efficiency still can reach standard (10 minutes
Within), or even it is routinely more taller as medium efficiency using common mixture of ice and water than it.
- 18~-21 DEG C of the cryosel aqueous mixtures that the present invention uses it can be seen from above-mentioned experimental result are than existing use
Water-ice or 2 DEG C of temperature changing water bank change warm water, there is preferably cooling effect, become temp effect and greatly reinforce, while also solving
Determined priming volume and resistance the problem of.
The present invention uses Myocardium protecting device of the cryosel aqueous mixtures as cooling thing it can be seen from above-mentioned test result
Cooling device, for stop jumping liquid have preferable cooling effect, become isothermal segment shorten half when, remain to reach standard.Cause
When this carries out myocardial preservation using cooling device of the present invention, it can ensure the low temperature for stoping jumping liquid, to reduce myocardial ischemia damage
Wound (" research of cold-blooded cardioplegia temperature and protecting effect relationship ", Li Demin etc., Chinese cardiovascular thoracic surgery magazine,
The 5th phase of volume 15 in October, 1999, the 308-309 pages；" Temperature Treatment of myocardial preservation ", Jiang Shulin etc., Harbin medical courses in general are big
Journal, the 6th phase of volume 34 in December, 2000, the 461-463 pages；" Temperature Treatment of myocardial preservation ", Li Demin etc., Chinese chest
Department of cardiovascular surgery magazine, the 2nd phase of volume 14 in April, 1998,123-125 pages).
Claims (1)
1. a kind of cooling device of Myocardium protecting device, it is characterised in that：The cooling device includes blood cooling line；
The blood cooling line is cooled down using cooling thing；
The cooling thing is cryosel aqueous mixtures；
The temperature of the cryosel aqueous mixtures is -18 DEG C~-21 DEG C；
In the cryosel aqueous mixtures, the mass-volume concentration of salt is 280~320g/L；
The cooling thing is set in constant temperature freezer；
The cooling device further includes temperature automatically controlled jacking system；
The temperature automatically controlled jacking system includes temp measuring system and control system, and the temp measuring system monitors the blood cooling tube
The temperature on road, and the temperature signal detected is transmitted in the control system；The control system is according to the temperature signal
Adjust the position relationship between the blood cooling line and the cooling thing；
The temp measuring system is infrared temperature measurement system or thermocouple temperature measurement system；
Included the following steps using the method that cooling thing cools down the blood cooling line：The cryosel aqueous mixtures are positioned over
In the constant temperature freezer, ice salt bath is obtained, the blood cooling line is carried out followed by the ice salt bath cold
But, and then make the mixture flow of heart-lung machine output blood and crystal through being cooled when the blood cooling line.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710407542.4A CN107252381B (en) | 2017-06-02 | 2017-06-02 | A kind of cooling device of Myocardium protecting device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710407542.4A CN107252381B (en) | 2017-06-02 | 2017-06-02 | A kind of cooling device of Myocardium protecting device |
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| Publication Number | Publication Date |
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| CN107252381A CN107252381A (en) | 2017-10-17 |
| CN107252381B true CN107252381B (en) | 2018-09-28 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW290460B (en) * | 1995-08-18 | 1996-11-11 | Ip Scient Inc | Perfusion hyperthermia treatment system and method |
| CN204111350U (en) * | 2014-09-16 | 2015-01-21 | 刘宇 | For the temperature varied cyclical water tank of myocardial preservation bottler temperature exchange |
| CN105250070A (en) * | 2015-09-08 | 2016-01-20 | 任立彦 | Cardiovascular surgery operation aseptic ice slush manufacturing method |
| CN206037581U (en) * | 2016-07-29 | 2017-03-22 | 刘智 | A cold and hot exchange water tank for cardiac surgery stops jump and performs operation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2285656Y (en) * | 1997-01-17 | 1998-07-08 | 王京玉 | Cardiac arrest liquid temp.-changing perfusion device |
| WO2000075577A2 (en) * | 1999-06-04 | 2000-12-14 | Lifestream International, Inc. | Cardioplegia heater/cooler system |
| US20070093697A1 (en) * | 2005-10-21 | 2007-04-26 | Theranova, Llc | Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature |
-
2017
- 2017-06-02 CN CN201710407542.4A patent/CN107252381B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW290460B (en) * | 1995-08-18 | 1996-11-11 | Ip Scient Inc | Perfusion hyperthermia treatment system and method |
| CN204111350U (en) * | 2014-09-16 | 2015-01-21 | 刘宇 | For the temperature varied cyclical water tank of myocardial preservation bottler temperature exchange |
| CN105250070A (en) * | 2015-09-08 | 2016-01-20 | 任立彦 | Cardiovascular surgery operation aseptic ice slush manufacturing method |
| CN206037581U (en) * | 2016-07-29 | 2017-03-22 | 刘智 | A cold and hot exchange water tank for cardiac surgery stops jump and performs operation |
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| Publication number | Publication date |
|---|---|
| CN107252381A (en) | 2017-10-17 |
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Effective date of registration: 20190902 Address after: 100029 No. 2 Anzhen Road, Chaoyang District, Beijing Patentee after: Beijing Anzhen Hospital, Capital Medical University Address before: 100029 Anzhenli Hospital Affiliated to Capital Medical University, Chaoyang District, Beijing Co-patentee before: Jia Zaishen Patentee before: Hou Xiaotong Co-patentee before: Li Ting |