CN107246761A - Mechanical superfreeze equipment and application process - Google Patents
Mechanical superfreeze equipment and application process Download PDFInfo
- Publication number
- CN107246761A CN107246761A CN201710438000.3A CN201710438000A CN107246761A CN 107246761 A CN107246761 A CN 107246761A CN 201710438000 A CN201710438000 A CN 201710438000A CN 107246761 A CN107246761 A CN 107246761A
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- Prior art keywords
- sample
- temperature
- mechanical
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- superfreeze
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D29/00—Arrangement or mounting of control or safety devices
- F25D29/005—Mounting of control devices
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K17/00—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations
- G06K17/0022—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations arrangements or provisious for transferring data to distant stations, e.g. from a sensing device
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2201/00—Insulation
- F25D2201/10—Insulation with respect to heat
- F25D2201/12—Insulation with respect to heat using an insulating packing material
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2400/00—General features of, or devices for refrigerators, cold rooms, ice-boxes, or for cooling or freezing apparatus not covered by any other subclass
- F25D2400/30—Quick freezing
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- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Combustion & Propulsion (AREA)
- Mechanical Engineering (AREA)
- Thermal Sciences (AREA)
- General Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of mechanical superfreeze equipment and application process, main control circuit connects sterlin refrigerator by temperature controller, for according to different samples, adjusting the cryogenic temperature of sterlin refrigerator, make the minimum regulation of temperature of the Sample preservation collected to 150 DEG C.Its application process is：The sample collected is put into rapidly in mechanical ultralow temperature sample freezing equipment and preserved, and it is different according to sample, different temperature are adjusted, make the temperature required for the sample tissue quick freeze of collection；Gained information after pattern detection is directly inputted in computer, while corresponding large database concept is set up, each Quick Response Code one sample of correspondence and sample information in database.Database root carries out data analysis according to the program write, and analysis result shows the individual health and the following possibility having an attack of one's old illness corresponding to the trend and sample of sample.
Description
Technical field
The present invention relates to a kind of low-temperature freezing facilities, especially a kind of mechanical superfreeze equipment belongs to low temperature cold
Freeze techniques field.
Background technology
Clinical research need largely with qualified living resources, rationally intactly preserve biological specimen meaning be very great
's.The U.S., European multinational and WHO have all put into several hundred million to hundreds of hundred million dollars and have set up macro-organism Sample Storehouse.From
Since 2009, China in units of hospital in the way of establish biological sample bank one after another.2015, the development of accurate medical science was again
China's biological sample bank development is promoted again.But, the preservation of biological sample bank at this stage still has many problems, example
Such as：Early stage people do not consider the loss of Sample Storehouse information for the preservation of Sample Storehouse, not freezen protective.This year starts
Freezen protective Sample Storehouse, but the preservation cryogenic temperature of general hospital is not low enough, also results in biological sample during later stage preservation
The excessive biological information of this loss, in addition, the gatherer process of hospital's Sample Storehouse is also not up to standard, during preserving, and can also
There is the situation of cross pollution.
At this stage, the store method of hospital is usually to add preservative or preserve sample using refrigerator, and market is highest
Store method be to be preserved in -80 DEG C of low temperature refrigerators, holding time of effective information relative to hospital's organ-tissue research when
Between not long enough.Simultaneously, when sample is gathered under the bad conditions such as field, low temperature refrigerator can not be carried with,
Sample tissue information can not be preserved in time.
Hospital carries out routine inspection, typically by the finger of inspection after the organ-tissue several years are preserved for organ-tissue
Mark is analyzed, and analysis method is generally artificial data analysis, during analysis, draws related conclusions.This is resulted in, number
According to preservation it is very inconvenient, experience some time after, there is a possibility that greatly to lose, and artificially analyze may
Can exist error and also can not processing relevant information in time, patient can not be fed back to after processing in time.
The content of the invention
To solve the technical problem that prior art is present, the present invention proposes a kind of mechanical superfreeze equipment and application
Method, using stirling refrigeration mechanism cold, refrigeration is rapid；Mechanical ultralow temperature tissue samples freezing equipment carries control system,
Solidification point and freeze-off time can be set, it is simple to operate；Using polystyrene as insulation material, heat-insulating property is stable；Drop
Warm rapid, biological information preserves more complete, and the holding time is longer, while equipment is equipped with laser two-dimensional code printing function, will
Sample information is preserved by Quick Response Code, then 2 D code information is inputted into computer, realizes that sample is quickly accurate with biological sample bank information
It is really shared.
To achieve the above object, the technical scheme is that：A kind of mechanical superfreeze equipment, including Stirling
Refrigeration machine, computer, the main control circuit connect sterlin refrigerator by temperature controller, for according to different samples,
The cryogenic temperature of sterlin refrigerator is adjusted, makes the minimum regulation of temperature of the Sample preservation collected to -150 DEG C, it is convenient rapid
The gathered sample tissue of freezing.
The mechanical superfreeze equipment is using stirling cycle engine as cooling module, and it is super that its refrigeration reaches
Low temperature exceedes the temperature of second steam compression-type refrigeration, and volume is less than the low temperature refrigerator of second steam compression-type refrigeration, phase
Safer, more effective for liquid nitrogen refrigerating, the scope of application is more extensive.
The main control circuit connects quick response code printer, is printed sample information to sample by quick response code printer and protected
Deposit on pipe；The upper Quick Response Code of preservation pipe is directly scanned by computer obtaining sample has relevant information, and classified storage is in computer correspondence phase
Close in database, for data analysis and preservation.
The computer stores several years sample data, sets up large database concept, and big data trend analysis is carried out by program, and
Information obtained by big data trend analysis is exported to user by mobile terminal, user is combined the individual information of oneself, and can
Wearable device or wired home robot are combined, formulate it is a set of can effectively the dietotherapy scheme of symptom management trend or motion side
Case.
A kind of application process of mechanical superfreeze equipment, its step is：
1）The sample collected is put into rapidly in mechanical ultralow temperature sample freezing equipment and preserved, and it is different according to sample, adjust
The different temperature of section, makes the temperature required for the sample tissue quick freeze of collection；
2）Set up the large database concept of sample
Gained information after pattern detection is directly inputted in computer, while corresponding large database concept is set up, in database
In each Quick Response Code correspondence one sample and sample information；Database root carries out data analysis, analysis according to the program write
As a result the individual health corresponding to the trend and sample of sample and the following possibility having an attack of one's old illness are shown；
3）Feedback of the information
Large database concept is analyzed into gained information to export to user by mobile terminal, in combination with the individual information of user, and
Combined with wearable device or wired home robot, formulate dietotherapy scheme or the motion side of a set of effective symptom management trend
The suggestion of case, user is fed back to by mobile terminal.
The beneficial effects of the invention are as follows：
The present invention will gather next biological specimen and be put into mechanical ultralow temperature tissue samples freezing equipment, and equipment uses Stirling system
Cold is freezed, and refrigeration is rapid；Mechanical ultralow temperature tissue samples freezing equipment carries control system, can set solidification point and
Freeze-off time, it is simple to operate；Using polystyrene as insulation material, heat-insulating property is stable；Cooling is rapid, and biological information is preserved
Obtain more complete, the holding time is longer, while equipment is equipped with laser two-dimensional code printing function, sample information is protected by Quick Response Code
Deposit, then 2 D code information is inputted into computer, realize that sample is quick and precisely shared with biological sample bank information.
The data obtained is transmitted to computer after pattern detection, in computer, enters line program analysis, the analysis of big data
There can be prediction for the Testing index trend of a certain patient, and can be carried out for the patient of a certain regional or a certain type
Trend analysis, the result that computer big data is analyzed passes to patient in time by mobile phone terminal, and mobile phone terminal can be disease simultaneously
People provides suggestion of some daily exercises and dietotherapy etc..
Brief description of the drawings
Fig. 1 is mechanical superfreeze equipment schematic of the invention.
Embodiment
The invention will be further described with embodiment below in conjunction with the accompanying drawings.
As shown in figure 1, the mechanical superfreeze equipment of the present invention, including sterlin refrigerator, temperature controller, electricity
Brain, quick response code printer, LED display, D/A digital analog converters, RAM（Random access memory）、EPROM（Erasable programmable ROM
Chip）.
Main control circuit connects sterlin refrigerator by temperature controller, special for according to different samples, adjusting this
The cryogenic temperature of woods refrigeration machine, makes the minimum regulation of temperature of the Sample preservation collected to -150 DEG C, facilitates quick freeze to be adopted
The sample tissue of collection.
Mechanical superfreeze equipment is used as cooling module, its ultralow temperature reached that freezes using stirling cycle engine
Degree exceedes the temperature of second steam compression-type refrigeration, and volume is less than the low temperature refrigerator of second steam compression-type refrigeration, relative to
Liquid nitrogen refrigerating is safer, more effective, and the scope of application is more extensive.
Main control circuit connects quick response code printer, is printed sample information to Sample preservation pipe by quick response code printer
On；The upper Quick Response Code of preservation pipe is directly scanned by computer obtaining sample has relevant information, and classified storage is in computer correspondence dependency number
According in storehouse, for data analysis and preservation.Computer is stored up to the data of sample several years, sets up large database concept, is carried out by program
Big data trend analysis, and information obtained by big data trend analysis is exported to user by mobile terminal, user is combined certainly
Oneself individual information, is combined with wearable device or wired home robot, formulate it is a set of can effective symptom management trend food
Treatment scheme or motion scheme.
A kind of application process of mechanical superfreeze equipment, it is characterised in that its step is：
1）The sample collected is put into rapidly in mechanical ultralow temperature sample freezing equipment and preserved, and it is different according to sample, adjust
The different temperature of section, makes the temperature required for the sample tissue quick freeze of collection；
2）Set up the large database concept of sample
Gained information after pattern detection is directly inputted in computer, while corresponding large database concept is set up, in database
In each Quick Response Code correspondence one sample and sample information.Database root carries out data analysis, analysis according to the program write
As a result the individual health corresponding to the trend and sample of sample and the following possibility having an attack of one's old illness are shown；
3）Feedback of the information
Large database concept is analyzed into gained information to export to user by mobile terminal, in combination with the individual information of user, and
Combined with wearable device or wired home robot, formulate dietotherapy scheme or the motion side of a set of effective symptom management trend
The suggestion of case, user is fed back to by mobile terminal.
The features of the present invention：
1. common refrigerator freezing temperature is -18 DEG C, the cryogenic temperature of ultra low temperature freezer is -80 DEG C, and sample tissue sample is general
- 80 DEG C are stored in, mechanical superfreeze equipment can cool the temperature to -150 DEG C.Biological specimen includes a variety of biological letters
Breath, is that the holding time of the biological specimen after superfreeze is big using ultralow temperature come the advantage that cold insulation freezes tissue samples
The earth is extended, and the holding time can reach 10-20, and the effective information in sample tissue can be preserved into more long.
2. mechanical ultralow temperature tissue samples freezing equipment uses advanced and efficient stirling cycle engine conduct
Cooling module, can reach the ultra low temperature that second steam compression-type refrigeration does not reach, and volume is smaller；Contrast other samples guarantor
The advantage of liquid nitrogen refrigerating used in depositing is more safety and volume is smaller, has the advantages that portability in collecting sample.
3. fast cooling can be realized, the glassy state storage of sample is realized.Mechanical ultralow temperature tissue samples freezing equipment
Ultrafast rate of temperature fall can be realized, and then the vitrifying of sample can be realized.Because the sample interior after vitrifying does not have shape
Into ice crystal, so avoiding the mechanical damage that ice crystal is caused to sample.And mechanical damage is most biological samples preservation effects
The not good main cause of fruit.Meanwhile, the biological sample of glassy state storage can retain more biological informations.
4. being furnished with laser two-dimensional code printer in machinist's superfreeze equipment, each sample has exclusive one
Name comprising sample, place, specimen types in Quick Response Code, Quick Response Code（Organ, tissue, blood plasma, body fluid etc.）, collection environment
（Temperature, humidity etc.）Information.Sample can classified storage in computer, be conducive to data analysis and preservation.
5. big data is analyzed.The data of sample several years are uniformly stored to computer, row data analysis, big data is programmed into
Data results are passed to patient, and give patient some effectively suggestions and fortune by analytic trend by mobile phone terminal at any time
The ameliorative ways such as dynamic dietotherapy.
6. mechanical ultralow temperature tissue samples freezing equipment can be widely used in the Cord blood of a variety of samples, such as：Embryo
Tire, stem cell, mammalian cell, sperm, egg cell, antibody etc..And suitable for field biological specimen in-site collecting, it is convenient wild
The freezen protective of outer rareness species sample.
7. the data of big health application can be from user, user can input the habits and customs of oneself, including duty
Industry, habits and customs, diet situation, motion conditions and operating pressure etc. help computer more Accurate Analysis data.
8. future be able to will can also be associated with wearable device or domestic robot, intelligent terminal, collected with this
More sample informations, realize information sharing, give personal more accurate rational suggestion.Future can also input a variety of diseases
Database, can be by the processing of big data, and the dependency relation observed between various data is subject to prevention and control.
Claims (5)
1. a kind of mechanical superfreeze equipment, including sterlin refrigerator, computer, it is characterised in that：The main control electricity
Road connects sterlin refrigerator by temperature controller, for according to different samples, adjusting the refrigeration temperature of sterlin refrigerator
Degree, makes the minimum regulation of temperature of the Sample preservation collected to -150 DEG C, the sample tissue for facilitating quick freeze to be gathered.
2. mechanical superfreeze equipment according to claim 1, it is characterised in that：The mechanical superfreeze
Equipment is using stirling cycle engine as cooling module, and its ultra low temperature reached that freezes exceedes second steam compression-type refrigeration
Temperature, and volume be less than second steam compression-type refrigeration low temperature refrigerator, it is safer relative to liquid nitrogen refrigerating, more effective, fit
It is more extensive with scope.
3. mechanical superfreeze equipment according to claim 1, it is characterised in that：The main control circuit connection two
Code printer is tieed up, is printed sample information to Sample preservation pipe by quick response code printer；Preservation pipe is directly scanned by computer
Upper Quick Response Code, which obtains sample, relevant information, and classified storage is in computer correspondence Relational database, for data analysis and guarantor
Deposit.
4. mechanical superfreeze equipment according to claim 1, it is characterised in that：The computer stores several years sample
Notebook data, sets up large database concept, carries out big data trend analysis by program, and information obtained by big data trend analysis is passed through
Mobile terminal is exported to user, user is combined the individual information of oneself, is combined with wearable device or wired home robot,
Formulate it is a set of can effective symptom management trend dietotherapy scheme or motion scheme.
5. the application process of any described mechanical superfreeze equipment of a kind of claim 1-4, it is characterised in that it is walked
Suddenly it is：
1）The sample collected is put into rapidly in mechanical ultralow temperature sample freezing equipment and preserved, and it is different according to sample, adjust
The different temperature of section, makes the temperature required for the sample tissue quick freeze of collection；
2）Set up the large database concept of sample
Gained information after pattern detection is directly inputted in computer, while corresponding large database concept is set up, in database
Each Quick Response Code one sample of correspondence and sample information；Database root carries out data analysis, analysis knot according to the program write
Fruit shows the individual health and the following possibility having an attack of one's old illness corresponding to the trend and sample of sample；
3）Feedback of the information
Large database concept is analyzed into gained information to export to user by mobile terminal, in combination with the individual information of user, and
Combined with wearable device or wired home robot, formulate dietotherapy scheme or the motion side of a set of effective symptom management trend
The suggestion of case, user is fed back to by mobile terminal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710438000.3A CN107246761A (en) | 2017-06-12 | 2017-06-12 | Mechanical superfreeze equipment and application process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710438000.3A CN107246761A (en) | 2017-06-12 | 2017-06-12 | Mechanical superfreeze equipment and application process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107246761A true CN107246761A (en) | 2017-10-13 |
Family
ID=60019051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710438000.3A Pending CN107246761A (en) | 2017-06-12 | 2017-06-12 | Mechanical superfreeze equipment and application process |
Country Status (1)
| Country | Link |
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| CN (1) | CN107246761A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114013827A (en) * | 2021-10-27 | 2022-02-08 | 冰山松洋生物科技(大连)有限公司 | Self-sustaining liquid nitrogen type biological preservation container |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08320163A (en) * | 1995-05-25 | 1996-12-03 | Sanyo Electric Co Ltd | Stirling freezer |
| CN1268033A (en) * | 1997-02-14 | 2000-09-27 | 拜奥马尔国际公司 | A system for predicting future health |
| CN201653030U (en) * | 2010-04-08 | 2010-11-24 | 中国电子科技集团公司第十六研究所 | Stirling cryogenic refrigerator |
| CN103500174A (en) * | 2013-09-04 | 2014-01-08 | 太仓艺斯高医疗器械科技有限公司 | Integration system and integration method for refrigeration device and sample storage device |
| CN105737471A (en) * | 2016-02-04 | 2016-07-06 | 上海理工大学 | Quick-cooling portable biological sample low-temperature freezer |
-
2017
- 2017-06-12 CN CN201710438000.3A patent/CN107246761A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08320163A (en) * | 1995-05-25 | 1996-12-03 | Sanyo Electric Co Ltd | Stirling freezer |
| CN1268033A (en) * | 1997-02-14 | 2000-09-27 | 拜奥马尔国际公司 | A system for predicting future health |
| CN201653030U (en) * | 2010-04-08 | 2010-11-24 | 中国电子科技集团公司第十六研究所 | Stirling cryogenic refrigerator |
| CN103500174A (en) * | 2013-09-04 | 2014-01-08 | 太仓艺斯高医疗器械科技有限公司 | Integration system and integration method for refrigeration device and sample storage device |
| CN105737471A (en) * | 2016-02-04 | 2016-07-06 | 上海理工大学 | Quick-cooling portable biological sample low-temperature freezer |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114013827A (en) * | 2021-10-27 | 2022-02-08 | 冰山松洋生物科技(大连)有限公司 | Self-sustaining liquid nitrogen type biological preservation container |
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