CN107212878A - Spinal cord injury bioelectrical signals conduction device - Google Patents

Spinal cord injury bioelectrical signals conduction device Download PDF

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Publication number
CN107212878A
CN107212878A CN201710560906.2A CN201710560906A CN107212878A CN 107212878 A CN107212878 A CN 107212878A CN 201710560906 A CN201710560906 A CN 201710560906A CN 107212878 A CN107212878 A CN 107212878A
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CN
China
Prior art keywords
bioelectrical signals
signals
processing
spinal cord
amplifier
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CN201710560906.2A
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Chinese (zh)
Inventor
唐佩福
季欣然
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Individual
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Individual
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Priority to CN201710560906.2A priority Critical patent/CN107212878A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Electrotherapy Devices (AREA)

Abstract

The invention discloses a kind of spinal cord injury bioelectrical signals conduction device.Wherein, the device includes:Bioelectrical signals receiver, for being installed on one end of spinal cord injury section and receiving the bioelectrical signals of spinal cord injury section one end;Processing of bioelectric signals amplifier, is connected with bioelectrical signals receiver, for bioelectrical signals to be amplified with processing;Bioelectrical signals generator, is connected with processing of bioelectric signals amplifier, for being installed on the other end of spinal cord injury section and receiving the bioelectrical signals after enhanced processing.The present invention solves technical problem in the prior art also without the equipment for effectively repairing spinal cord injury.

Description

Spinal cord injury bioelectrical signals conduction device
Technical field
The present invention relates to field of medical device, in particular to a kind of spinal cord injury bioelectrical signals conduction device.
Background technology
With the development of countries in the world economic level, the trend increased year by year is presented in spinal cord injury incidence.Spinal cord injury It is that spinal injury most serious is also most common complication, often leads to damage section with the serious dysfunction of lower limb body.Ridge Marrow damage can not only bring the grievous injury of body and psychology to sufferers themselves, can also cause huge economy to bear to entire society Load.Socie-economic loss caused by spinal cord injury, prevention, treatment and rehabilitation for spinal cord injury have turned into current doctor One big problem of educational circles, does not have also effective equipment to recover patient's spinal function for spinal cord injury at present.
For it is above-mentioned in the prior art also without the equipment for effectively repairing spinal cord injury the problem of, not yet propose at present effective Solution.
The content of the invention
The embodiments of the invention provide a kind of spinal cord injury bioelectrical signals conduction device, at least to solve prior art In also without effectively repair spinal cord injury equipment technical problem.
There is provided a kind of spinal cord injury bioelectrical signals conduction device, bag for one side according to embodiments of the present invention Include:Bioelectrical signals receiver, for being installed on one end of spinal cord injury section and receiving the biology of spinal cord injury section one end Electric signal;Processing of bioelectric signals amplifier, is connected with bioelectrical signals receiver, for bioelectrical signals to be amplified with place Reason;Bioelectrical signals generator, is connected with processing of bioelectric signals amplifier, the other end for being installed on spinal cord injury section And receive the bioelectrical signals after enhanced processing.
Further, bioelectrical signals receiver is annular tube shaped wrapping structure.
Further, multiple microelectrodes are distributed with bioelectrical signals receiver inner surface.
Further, bioelectrical signals generator is annular tube shaped wrapping structure.
Further, multiple microelectrodes are distributed with bioelectrical signals generator inner surface.
Further, bioelectrical signals receiver and bioelectrical signals generator are annular tube shaped wrapping structure and size It is identical.
Further, processing of bioelectric signals amplifier includes first interface and second interface, bioelectrical signals receiver It is connected by first interface with processing of bioelectric signals amplifier, bioelectrical signals generator passes through second interface and biological telecommunications The connection of number process amplifier.
Further, bioelectrical signals receiver is connected by the first integrated circuit with processing of bioelectric signals amplifier.
Further, bioelectrical signals generator is connected by the second integrated circuit with processing of bioelectric signals amplifier.
Further, the position being connected on the first integrated circuit with processing of bioelectric signals amplifier is provided with to be connect with first The position being connected on 3rd interface of mouth matching, the second integrated circuit with processing of bioelectric signals amplifier is provided with to be connect with second 4th interface of mouth matching.
In embodiments of the present invention, by the bioelectrical signals receiver of the one end for being installed on spinal cord injury section, receive Bioelectrical signals, are then amplified by the bioelectrical signals of spinal cord injury section one end by processing of bioelectric signals amplifier Reason, finally receives the biology after enhanced processing by the bioelectrical signals generator for the other end for being installed on spinal cord injury section Electric signal, has reached the purpose of the real-time transmission to bioelectrical signals, it is achieved thereby that repairing patient's spinal cord work(after spinal cord injury The technique effect of energy, and then solve technical problem in the prior art also without the equipment for effectively repairing spinal cord injury.
Brief description of the drawings
Accompanying drawing described herein is used for providing a further understanding of the present invention, constitutes the part of the application, this hair Bright schematic description and description is used to explain the present invention, does not constitute inappropriate limitation of the present invention.In the accompanying drawings:
Fig. 1 is a kind of structural representation of spinal cord injury bioelectrical signals conduction device according to embodiments of the present invention; And
Fig. 2 is the structure of bioelectrical signals receiver according to embodiments of the present invention or bioelectrical signals generator inner surface Schematic diagram;
Fig. 3 is the structural representation of processing of bioelectric signals device according to embodiments of the present invention;And
Fig. 4 is the structural representation of processing of bioelectric signals amplifier according to embodiments of the present invention.
Embodiment
In order that those skilled in the art more fully understand the present invention program, below in conjunction with the embodiment of the present invention Accompanying drawing, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only The embodiment of a part of the invention, rather than whole embodiments.Based on the embodiment in the present invention, ordinary skill people The every other embodiment that member is obtained under the premise of creative work is not made, should all belong to the model that the present invention is protected Enclose.
Embodiment 1
According to embodiments of the present invention there is provided a kind of product embodiments of spinal cord injury with bioelectrical signals conduction device, Fig. 1 is spinal cord injury according to embodiments of the present invention bioelectrical signals conduction device, as shown in figure 1, the device includes biology Electric signal receiver 1, processing of bioelectric signals amplifier 2 and bioelectrical signals generator 3, wherein, bioelectrical signals receiver 1, for being installed on one end of spinal cord injury section and receiving the bioelectrical signals of spinal cord injury section one end;At bioelectrical signals Amplifier 2 is managed, is connected with bioelectrical signals receiver 1, for bioelectrical signals to be amplified with processing;Bioelectrical signals occur Device 3, is connected with processing of bioelectric signals amplifier 2, for being installed on the other end of spinal cord injury section and receiving by amplification Bioelectrical signals after processing.
In embodiments of the present invention, by the bioelectrical signals receiver 1 of the one end for being installed on spinal cord injury section, receive Bioelectrical signals, are then amplified by the bioelectrical signals of spinal cord injury section one end by processing of bioelectric signals amplifier 2 Processing, is finally received after enhanced processing by the bioelectrical signals generator 3 for the other end for being installed on spinal cord injury section Bioelectrical signals, have reached the purpose of the real-time transmission to bioelectrical signals, it is achieved thereby that repairing patient's ridge after spinal cord injury The technique effect of marrow function, and then solve technical problem in the prior art also without the equipment for effectively repairing spinal cord injury.
In a particular application, the present invention is based on microelectric signals transfer theory, by being saved above and below spinal cord injury of connecting Section recovers the purpose of spinal cord biological electricity transmission to reach, in concrete operations, close to damage on Patients of Spinal damage section Bioelectrical signals receiver 1 is applied at section, the life by being connected with the bioelectrical signals receiver 1 after bioelectrical signals is received Bioelectrical signals are amplified after processing by thing Electric signal processing amplifier 2, are transferred under Patients of Spinal damage section and are leaned on Bioelectrical signals generator 3 at nearly damage section, the bioelectrical signals for completing spinal cord injury transmit reparation spinal cord injury in real time Patient's spinal function afterwards.
In a kind of optional embodiment, bioelectrical signals receiver 1 is annular tube shaped wrapping structure.
Specifically, bioelectrical signals receiver 1 can be the annular tube shaped wrapping structure for being capable of free-open-close, in order to reality Now spinal cord is engaged.
In a kind of optional embodiment, on the basis of bioelectrical signals receiver 1 is annular tube shaped wrapping structure, figure 2 can represent the schematic diagram of the inner surface of bioelectrical signals receiver 1, as shown in Fig. 2 the inner surface of bioelectrical signals receiver 1 Multiple microelectrodes are distributed with.
Specifically, the inner surface of bioelectrical signals receiver 1 can be covered with microelectrode, and microelectrode can be according to certain Array is arranged.
Specifically, bioelectrical signals receiver 1 can be collected on damage section by way of multi-electrode is received close to damage Hinder spinal cord injury bioelectrical signals at section, electrode coverage is region-wide, the passive electrode area of coverage of spinal cord difference in functionality After spinal cord electric signal in the range of domain, it can be conducted according to electrode arrangement order to processing of bioelectric signals amplifier 2, by biology Electric signal carries out handling appropriate amplification.
In a kind of optional embodiment, bioelectrical signals generator 3 is annular tube shaped wrapping structure.
Specifically, bioelectrical signals generator 3 can be the annular tube shaped wrapping structure for being capable of free-open-close, in order to reality Now spinal cord is engaged.
In a kind of optional embodiment, on the basis of bioelectrical signals generator 3 is annular tube shaped wrapping structure, figure 2 can represent the schematic diagram of the inner surface of bioelectrical signals generator 3, as shown in Fig. 2 the inner surface of bioelectrical signals generator 3 Multiple microelectrodes are distributed with.
Specifically, the inner surface of bioelectrical signals generator 3 can be covered with microelectrode, and microelectrode can be according to certain Array is arranged.
Specifically, bioelectrical signals generator 3 is connected with processing of bioelectric signals amplifier 2, damaged by being covered in spinal cord Hinder the gamut microelectrode located below section, the bioelectrical signals after enhanced processing are transferred to the ridge below spinal cord injury section Marrow, completes whole spinal cord anastomosis, reaches the transmittance process of bioelectrical signals.
In a kind of optional embodiment, in order to ensure that bioelectrical signals receiver 1 and bioelectrical signals generator 3 are covered Spinal cord area size it is identical, the shape and size of bioelectrical signals receiver 1 and bioelectrical signals generator 3 can be made complete It is exactly the same, spinal cord injury is connected by bioelectrical signals receiver 1 and bioelectrical signals generator 3 and is damaged spinal cord above and below cross section Tissue, while junction corresponds to identical spinal cord area up and down, therefore, can to dominate scope transmission spinal cord bioelectrical signals on an equal basis Choosing, bioelectrical signals receiver 1 is annular tube shaped wrapping structure with bioelectrical signals generator 3 and size is identical.
In a kind of optional embodiment, processing of bioelectric signals amplifier 2 includes first interface and second interface, biological Electric signal receiver 1 is connected by first interface with processing of bioelectric signals amplifier 2, and bioelectrical signals generator passes through second Interface is connected with processing of bioelectric signals amplifier 2.
Herein it should be noted that the first interface and second interface of processing of bioelectric signals amplifier 2 can be protrusion The interface of setting or the interface for setting of caving in.
In a kind of optional embodiment, bioelectrical signals receiver 1 passes through at the first integrated circuit and bioelectrical signals Reason amplifier 2 is connected, wherein, the first integrated circuit is micro-line road.
In a kind of optional embodiment, bioelectrical signals generator 3 passes through at the second integrated circuit and bioelectrical signals Reason amplifier 2 is connected, wherein, the second integrated circuit is micro-line road.
In a kind of optional embodiment, the position being connected on the first integrated circuit with processing of bioelectric signals amplifier 2 It is provided with the position being connected on the 3rd interface matched with first interface, the second integrated circuit with processing of bioelectric signals amplifier 2 Install the 4th interface for being equipped with and being matched with second interface.
In a kind of optional embodiment, bioelectrical signals receiver 1, processing of bioelectric signals amplifier 2 and biological electricity The material of signal generator 3 is biocompatible materials (such as silicon, hydrogel chip), wherein, bioelectrical signals connect Receive the size of device 1 and bioelectrical signals generator 3 can be divided into it is small, in, big three models, the diameter of three models can distinguish For 8mm, 10mm, 12mm.
In a kind of optional embodiment, the spinal cord injury of the embodiment of the present invention is with bioelectrical signals conduction device except bag Include outside bioelectrical signals receiver 1, processing of bioelectric signals amplifier 2 and bioelectrical signals generator 3, can also include Processing of bioelectric signals device, driver etc., wherein, one end and the processing of bioelectric signals amplifier 2 of processing of bioelectric signals device One end of connection, the other end and driver is connected, and the other end of driver is connected with bioelectrical signals generator 3, biological telecommunications The microelectrode that number receiver 1 includes can be detecting electrode, and mainly for detection of bioelectrical signals, bioelectrical signals are by life After thing Electric signal processing amplifier 2 amplifies, handled by processing of bioelectric signals device, then by driver to treated life Thing electric signal is amplified and forms bioelectric stimulation signals, and applies to bioelectrical signals generator 3, therefore bioelectrical signals It can be stimulating electrode that generator 3, which can also include a part in electrode, electrode, for stimulating impaired spinal cord regeneration to go out biology Electric signal.
In a kind of optional embodiment, the microelectrode that bioelectrical signals receiver 1 and bioelectrical signals generator 3 include Contact point array electrode can be used, cuff electrode can be specifically used, can be in bioelectrical signals receiver 1 and biological telecommunications First is set to switch switch arrays between the input of number process amplifier 2, and in the defeated of processing of bioelectric signals amplifier 2 Go out between end and bioelectrical signals generator 3 and set second to switch switch arrays, have on the first switching switch arrays for connecting Deliver a child the first switch of thing electric signal receiver 1 and processing of bioelectric signals amplifier 2, it is useful on the second switching switch arrays In connection processing of bioelectric signals amplifier 2 and the second switch of bioelectrical signals generator 3, switching switch arrays and switch Effect is effect and the annexation for changing each electrode according to two arrays situation of the contact with spinal cord two ends, prevents spinal cord god The incorrect interconnection of channel and the correct interconnection of recovery.
In a kind of optional embodiment, the effect of above-mentioned processing of bioelectric signals device is mainly identification and extracts nerve letter Number, as shown in figure 3, the processing of bioelectric signals device can include active low-pass filter, the active low-pass filter includes one Individual RC network and an operation amplifier circuit, the nerve signal after amplifying through amplifier are exported to computing by resistance R2, R3 The in-phase input end of amplifier circuit, is connected with electric capacity C1 and by electric capacity C1 on the in-phase input end of operation amplifier circuit Electric capacity C2 is connected in parallel on ground connection, the node and operation amplifier circuit output end between resistance R2, R3, in operation amplifier Resistance R1 is connected with the inverting input of device circuit and is grounded by resistance R1, in the inverting input of operation amplifier circuit With being connected in parallel to resistance Rf in output end.
In a kind of optional embodiment, as shown in figure 4, processing of bioelectric signals amplifier 2 can include amplifier 11, Amplifier 22 and adder 33, amplifier 11, the output end of amplifier 22 are connected with the input of adder 33, adder 33 Output end as processing of bioelectric signals amplifier 2 output end;The detecting electrode of bioelectrical signals receiver 1 is using card skin electricity Pole, cuff electrode is connected with the inverting input of above-mentioned amplifier 11, amplifier 22 and amplifier 11, the same phase of amplifier 22 Input is connected, the effect of processing of bioelectric signals amplifier 2 be by electrode detection to small-signal be amplified to subsequent conditioning circuit The voltage amplitude that can further handle.
It should be noted that term used herein above is merely to describe embodiment, and be not intended to restricted root According to the illustrative embodiments of the application.As used herein, unless the context clearly indicates otherwise, otherwise singulative It is also intended to include plural form, additionally, it should be understood that, when in this manual using term "comprising" and/or " bag Include " when, it indicates existing characteristics, step, operation, device, component and/or combinations thereof.
Unless specifically stated otherwise, the part and positioned opposite, the digital table of step otherwise illustrated in these embodiments Do not limited the scope of the invention up to formula and numerical value.Simultaneously, it should be appreciated that for the ease of description, each portion shown in accompanying drawing The size divided not is to be drawn according to actual proportionate relationship.For technology, side known to person of ordinary skill in the relevant Method and equipment may be not discussed in detail, but in the appropriate case, the technology, method and apparatus should be considered as authorizing explanation A part for book.In shown here and discussion all examples, any occurrence should be construed as merely exemplary, and Not by way of limitation.Therefore, the other examples of exemplary embodiment can have different values.It should be noted that:Similar label Similar terms is represented in following accompanying drawing with letter, therefore, once it is defined in a certain Xiang Yi accompanying drawing, then subsequent attached It need not be further discussed in figure.
In the description of the invention, it is to be understood that the noun of locality such as " forward and backward, upper and lower, left and right ", " laterally, vertical, Vertically, orientation or position relationship indicated by level " and " top, bottom " etc. are normally based on orientation shown in the drawings or position and closed System, is for only for ease of the description present invention and simplifies description, in the case where not making opposite explanation, these nouns of locality are not indicated that There must be specific orientation or with specific azimuth configuration and operation with the device or element for implying meaning, therefore can not manage Solve as limiting the scope of the invention;The noun of locality " inside and outside " refers to relative to inside and outside each part profile in itself.
For the ease of description, space relative terms can be used herein, such as " ... on ", " ... top ", " ... upper surface ", " above " etc., for describing such as a device shown in the figure or feature and other devices or spy The spatial relation levied.It should be appreciated that space relative terms are intended to comprising the orientation except device described in figure Outside different azimuth in use or operation.If for example, the device in accompanying drawing is squeezed, be described as " in other devices It will be positioned as " under other devices or construction after the device of part or construction top " or " on other devices or construction " Side " or " under other devices or construction ".Thus, exemplary term " ... top " can include " ... top " and " in ... lower section " two kinds of orientation.The device can also other different modes positioning (being rotated by 90 ° or in other orientation), and And respective explanations are made to the relative description in space used herein above.
Furthermore, it is necessary to which explanation, limits parts, it is only for be easy to using the word such as " first ", " second " Corresponding parts are distinguished, such as without Stated otherwise, above-mentioned word does not have particular meaning, therefore it is not intended that to this The limitation of invention protection domain.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (10)

1. a kind of spinal cord injury bioelectrical signals conduction device, it is characterised in that including:
Bioelectrical signals receiver, for being installed on one end of spinal cord injury section and receiving the biology of spinal cord injury section one end Electric signal;
Processing of bioelectric signals amplifier, is connected with the bioelectrical signals receiver, for being carried out to the bioelectrical signals Enhanced processing;
Bioelectrical signals generator, is connected with the processing of bioelectric signals amplifier, for being installed on spinal cord injury section The other end simultaneously receives the bioelectrical signals after enhanced processing.
2. device according to claim 1, it is characterised in that the bioelectrical signals receiver is annular tube shaped wrapping knot Structure.
3. device according to claim 2, it is characterised in that the bioelectrical signals receiver inner surface is distributed with multiple Microelectrode.
4. device according to claim 1, it is characterised in that the bioelectrical signals generator is annular tube shaped wrapping knot Structure.
5. device according to claim 4, it is characterised in that the bioelectrical signals generator inner surface is distributed with multiple Microelectrode.
6. device according to claim 1, it is characterised in that the bioelectrical signals receiver and the bioelectrical signals Generator is annular tube shaped wrapping structure and size is identical.
7. device according to claim 1, it is characterised in that the processing of bioelectric signals amplifier includes first interface And second interface, the bioelectrical signals receiver passes through the first interface and the processing of bioelectric signals amplifier and connects Connect, the bioelectrical signals generator is connected by the second interface with the processing of bioelectric signals amplifier.
8. device according to claim 7, it is characterised in that the bioelectrical signals receiver passes through the first integrated circuit It is connected with the processing of bioelectric signals amplifier.
9. device according to claim 8, it is characterised in that the bioelectrical signals generator passes through the second integrated circuit It is connected with the processing of bioelectric signals amplifier.
10. device according to claim 9, it is characterised in that with the bioelectrical signals on first integrated circuit The position of process amplifier connection is provided with the 3rd interface matched with the first interface, second integrated circuit and institute The position for stating the connection of processing of bioelectric signals amplifier is provided with the 4th interface matched with the second interface.
CN201710560906.2A 2017-07-11 2017-07-11 Spinal cord injury bioelectrical signals conduction device Pending CN107212878A (en)

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Application Number Priority Date Filing Date Title
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1810203A (en) * 2005-12-30 2006-08-02 东南大学 Microelectronic system aided nerve channel function recovering method and apparatus
US20080234791A1 (en) * 2007-01-17 2008-09-25 Jeffrey Edward Arle Spinal cord implant systems and methods
US20100217339A1 (en) * 2009-02-23 2010-08-26 Kane Seth A Carbon nanotube micro-array relay system for providing nerve sitmulation output and sensation input acrodd proximal and distal ends of damaged spinal cord
RU2401137C1 (en) * 2009-02-24 2010-10-10 Дмитрий Васильевич Белик Body function activation system
CN102512757A (en) * 2011-12-12 2012-06-27 中国科学院电工研究所 Method and device for injury potential compensation after spinal cord injury
CN208286999U (en) * 2017-07-11 2018-12-28 唐佩福 Spinal cord injury bioelectrical signals conduction device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1810203A (en) * 2005-12-30 2006-08-02 东南大学 Microelectronic system aided nerve channel function recovering method and apparatus
US20080234791A1 (en) * 2007-01-17 2008-09-25 Jeffrey Edward Arle Spinal cord implant systems and methods
US20100217339A1 (en) * 2009-02-23 2010-08-26 Kane Seth A Carbon nanotube micro-array relay system for providing nerve sitmulation output and sensation input acrodd proximal and distal ends of damaged spinal cord
RU2401137C1 (en) * 2009-02-24 2010-10-10 Дмитрий Васильевич Белик Body function activation system
CN102512757A (en) * 2011-12-12 2012-06-27 中国科学院电工研究所 Method and device for injury potential compensation after spinal cord injury
CN208286999U (en) * 2017-07-11 2018-12-28 唐佩福 Spinal cord injury bioelectrical signals conduction device

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