CN107174208A - A kind of photoacoustic imaging system and method suitable for peripheral vascular imaging - Google Patents
A kind of photoacoustic imaging system and method suitable for peripheral vascular imaging Download PDFInfo
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- CN107174208A CN107174208A CN201710374235.0A CN201710374235A CN107174208A CN 107174208 A CN107174208 A CN 107174208A CN 201710374235 A CN201710374235 A CN 201710374235A CN 107174208 A CN107174208 A CN 107174208A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/725—Details of waveform analysis using specific filters therefor, e.g. Kalman or adaptive filters
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Abstract
The present invention discloses a kind of photoacoustic imaging system and method suitable for peripheral vascular imaging.Wherein, the system includes：The trigger being connected respectively with laser and multi-channel data acquisition board；Laser；Include the scanning head of fibre bundle, ultrasonic transducer and clamper, fibre bundle includes multifiber, and one end is connected with laser, the average one-to-two of the other end is symmetrically fixed on the both sides of ultrasonic transducer by clamper, to realize that acousto-optic is coaxial.The laser that fibre bundle is used to produce in laser is irradiated to target to be scanned generation photoacoustic signal, and ultrasonic transducer is used to receive photoacoustic signal；The mechanical arm of scanning head is removably installed, mechanical arm is used to drive scanning head to be scanned target to be scanned；The multi-channel data acquisition board being connected respectively with ultrasonic transducer and host computer.What the present invention was provided is applied to be used for photoacoustic imaging system and the method that peripheral artery disease is diagnosed, and improves the security and accuracy of imaging.
Description
Technical field
The present invention relates to medicine technology field, and in particular to a kind of photoacoustic imaging system suitable for peripheral vascular imaging and
Method.
Background technology
Peripheral artery disease (Peripheral Vascular Disease, PVD) refers to influence in addition to heart and encephalic
Artery, the various Pathological Physiology syndromes of vein and Lymphatic Circulation, " heart disease beyond heart " is referred to as in the industry, to the heart
Cranial vascular disease has potential pathogenic effects.
It is not difficult according to the diagnosis that human clinical's symptom, sign and special examined carry out peripheral vascular disease, such as carry out
Ultrasonic screening, Magnetic resonance imaging, angiographic imaging.But, ultrasonic imaging technique still accurately can not clearly show small blood
Pipe lesion, Magnetic resonance imaging can cause certain injury using ray to human body, the radiation of angiographic imaging and contrast agent
Human body is caused to injure to a certain degree using meeting.
Therefore, a kind of system how is proposed, it is possible to increase the security to blood vessel imaging turns into industry weight urgently to be resolved hurrily
Want problem.
The content of the invention
For defect of the prior art, the present invention provide a kind of photoacoustic imaging system suitable for peripheral vascular imaging and
Method.
On the one hand, the present invention proposes a kind of photoacoustic imaging system suitable for peripheral vascular imaging, including trigger, laser
Device, scanning head, mechanical arm, multi-channel data acquisition board and host computer, wherein：
The trigger is connected with the laser and the multi-channel data acquisition board respectively；The scanning head includes
Fibre bundle, ultrasonic transducer and clamper, the fibre bundle include multifiber, one end of the fibre bundle and the laser
The average one-to-two of the other end that is connected symmetrically is fixed on the both sides of the ultrasonic transducer by the clamper, to realize that acousto-optic is total to
Axle；The laser that the fibre bundle is used to produce in the laser is irradiated to target to be scanned generation photoacoustic signal, the ultrasound
Transducer is used to receive the photoacoustic signal；The scanning head is removably mounted on the mechanical arm, the mechanical arm
For driving the scanning head to be scanned the target to be scanned；The multi-channel data acquisition board surpasses with described respectively
Sonic transducer is connected with the host computer.
Wherein, the clamper includes three mounting holes, and two of which mounting hole, which is respectively mounted, described is divided into two
The multifiber divided, another mounting hole installs the ultrasonic transducer, and described two mounting holes are on another described installation
Hole is symmetrical arranged.
Wherein, the system also includes：The trigger is connected with the ultrasonic transducer, and the ultrasonic transducer is also used
In generation and reception ultrasonic signal.
Wherein, the laser uses multi-wavelength's pulse laser.
Wherein, the clamper is manufactured using 3D printing technique.
Wherein, the laser is connected by fiber coupler with the fibre bundle.
Wherein, the fibre bundle includes 128 optical fiber.
Wherein, the ultrasonic transducer is linear array ultrasound transducer.
On the other hand, the present invention propose a kind of photoacoustic imaging system using described in any of the above-described embodiment be applied to it is outer
The acousto-optic imaging method of all blood vessel imagings, including：
Laser launches laser, while sending the first trigger signal to trigger；
The trigger, which receives to send to multi-channel data acquisition board after first trigger signal, gathers signal；
The laser is irradiated to target to be scanned by the fibre bundle and produces photoacoustic signal；
Ultrasonic transducer receives the photoacoustic signal；
The optoacoustic letter that multi-channel data acquisition board ultrasonic transducer according to the collection signal acquisition is received
Number, and the photoacoustic signal is sent to host computer；
The host computer is imaged based on the photoacoustic signal to the target to be scanned.
A kind of another further aspect, being applied to for photoacoustic imaging system using described in any of the above-described embodiment of present invention proposition is outer
The multi-modal acousto-optic imaging method of all blood vessel imagings, including：
Laser launches laser, while sending the first trigger signal to trigger；
The trigger, which receives to send to multi-channel data acquisition board after first trigger signal, gathers signal, and
Send after the collection signal preset time, the second trigger signal is sent to ultrasonic transducer；
The laser is irradiated to target to be scanned by fibre bundle and produces photoacoustic signal；
The ultrasonic transducer receives the photoacoustic signal；After second trigger signal is received, to mesh to be scanned
Mark transmitting ultrasonic signal, and receive the ultrasonic signal of reflection；
The light that multi-channel data acquisition board ultrasonic transducer according to the collection signal acquisition is received
Acoustical signal and the ultrasonic signal of the reflection, and the ultrasonic signal of the photoacoustic signal and the reflection is sent to host computer；
Ultrasonic signal of the host computer based on the photoacoustic signal and the reflection carries out many to the target to be scanned
Modality.
The photoacoustic imaging system and method suitable for peripheral vascular imaging that the present invention is provided, are launched by laser and swashed
Light, while sending trigger signal to trigger, makes trigger send collection signal to multi-channel data acquisition board, laser passes through light
Fine beam irradiation target to be scanned produces photoacoustic signal, and multi-channel data acquisition board is received according to collection signal acquisition ultrasonic transducer
Photoacoustic signal, and by photoacoustic signal be transferred to host computer imaging, realize human peripheral blood pipe morphology positioning and function generation
Thank to imaging, improve the security and accuracy of the imaging of human peripheral blood pipe.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is the accompanying drawing used required in technology description to make one simply to introduce, it should be apparent that, drawings in the following description are this hairs
Some bright embodiments, for those of ordinary skill in the art, on the premise of not paying creative work, can be with root
Other accompanying drawings are obtained according to these accompanying drawings.
Fig. 1 is the structural representation for the photoacoustic imaging system that one embodiment of the invention is applied to peripheral vascular imaging；
Fig. 2 is the schematic flow sheet for the acousto-optic imaging method that one embodiment of the invention is applied to peripheral vascular imaging；
Fig. 3 is the flow signal for the multi-modal acousto-optic imaging method that another embodiment of the present invention is applied to peripheral vascular imaging
Figure；
Description of reference numerals：
1- triggers；2- lasers；
3- host computers；4- scanning heads；
5- mechanical arms；6- multi-channel data acquisition boards；
41- fibre bundles；42- ultrasonic transducers；
43- clampers.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, below in conjunction with attached in the embodiment of the present invention
Figure, the technical scheme in the embodiment of the present invention is explicitly described, it is clear that described embodiment is a part of the invention
Embodiment, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making wound
The every other embodiment obtained under the premise of the property made work, belongs to the scope of protection of the invention.
Photoacoustic imaging is a kind of optical absorption characteristic difference based on inside biological tissue being surging forward in recent years, with light
Sound possesses the high contrast features and pure ultrasound of pure optical imagery as the novel lossless biomedical imaging method of information carrier
The deep penetration characteristic of imaging.Photoacoustic imaging is by detecting the light that the absorber of light in biological tissue is produced by instantaneous thermoelastic effect
Acoustical signal, replaces the photon detection in optical imagery with sound wave, the influence of optical scattering is avoided from principle, high score is breached
Resolution optical imagery depth " soft limiting " (about 1mm), can be achieved the deep tissues living imaging that depth reaches 7cm.Photoacoustic imaging is not
Only possess extremely sensitive light absorbs contrast to obtain the function information of biological tissue, and deep tissues can be carried out across chi
Spend high-resolution imaging.
Fig. 1 is the structural representation for the photoacoustic imaging system that one embodiment of the invention is applied to peripheral vascular imaging, such as Fig. 1
It is shown, the photoacoustic imaging system suitable for peripheral vascular imaging that the present invention is provided, including trigger 1, laser 2, scanning spy
First 4, mechanical arm 5, multi-channel data acquisition board 6 and host computer 3, wherein：
Trigger 1 is connected with laser 2 and multi-channel data acquisition board 6 respectively；Scanning head 4 includes fibre bundle 41, surpassed
Sonic transducer 42 and clamper 43, fibre bundle 41 include multifiber, and one end of fibre bundle 41 is connected with laser 2, the other end
Average one-to-two is symmetrically fixed on the both sides of ultrasonic transducer 42 by clamper 43, to realize that acousto-optic is coaxial；Fibre bundle 41 is used
Target to be scanned is irradiated in the laser for producing laser 2 and produces photoacoustic signal, and ultrasonic transducer 42 is used to receive the light
Acoustical signal；Scanning head 4 is removably mounted on mechanical arm 5, and mechanical arm 5 is used to drive scanning head 4 to be scanned action；
Multi-channel data acquisition board 6 is connected with ultrasonic transducer 42 and host computer 3 respectively.
Laser 2 sends laser, while sending the first trigger signal to trigger 1, the laser is shone by fibre bundle 41
The target to be scanned is mapped to, the target to be scanned is the object for needing to carry out photoacoustic imaging, for example, can be the four of human body
Limb, the laser is irradiated to after the target to be scanned, can produce photoacoustic signal, and ultrasonic transducer 42 can receive the light
Acoustical signal.Trigger 1 is used for after the first trigger signal of laser 2 is received, and opens multi-channel data acquisition board 6, makes many
The photoacoustic signal that the collection ultrasonic transducer 42 of channel data capture card 6 is received.Wherein, trigger 1 uses FPGA circuitry
Plate, on the one hand first trigger signal can be widened to us ranks and sent to multi-channel data acquisition board 6, make multichannel number
The photoacoustic signal can be gathered according to capture card 6, pulse width delay 1ms outputs is on the other hand expanded, triggers and then control super
Sonic transducer launches ultrasonic wave, gathers ultrasonic signal；Laser 2 can use 532-1064nm multi-wavelength adjustable pulse laser
Device, maximum laser pulse energy：80mJ；Work capacity：20mJ/cm2Hereinafter, ANSI safety standards are met.
Clamper 43 is used for the relative position for fixing fibre bundle 41 and ultrasonic transducer 42, and then realizes that acousto-optic is coaxial, example
As fibre bundle 41 includes 128 optical fiber, be equally divided into each 64 of two groups of optical fiber, two groups of optical fiber by clamper 43 symmetrically
Both sides fixed to ultrasonic transducer 42, the hot spot that two groups of fibre bundles are produced is respectively radiated to the target to be scanned, from
And can realize that acousto-optic is coaxial, it is ensured that ultrasonic transducer 42 can receive the photoacoustic signal worked well.Wherein, ultrasound is changed
Energy device 42 can use centre frequency 5-30MHz, vertical plane 20 ± 4mm of focal length, support coding excitation mode, support all scannings
Form.
Mechanical arm 5 can realize being accurately positioned in three dimensions of scanning head 4, and mechanical arm 5 can use six axle machines
Tool arm and AC Servo Motor Control, enable geometry and position of the mechanical arm 5 according to target to be scanned, drive scanning to visit
First 4 carry out accurate scan.For example, mechanical arm 5 can be six-freedom degree motion in 850mm spatial dimension in radius, it is transported
Dynamic precision 0.1mm, single shaft maximum movement speed 1m/s, by the control of programming realization movement locus, make mechanical arm 5 complete two dimension
Or three-dimensional motion.Mechanical arm 5 can be controlled by host computer 3.
Multi-channel data acquisition board 6 is used to collect the photoacoustic signal, multi-channel data acquisition from ultrasonic transducer 42
Card 6 can be connected by PCI slot with host computer 3, and the photoacoustic signal collected is sent to host computer 3.Host computer 3
For that can carry out tomography or three-dimensional imaging to the target to be scanned based on the photoacoustic signal, imaging depth maximum is reachable
10cm, imaging space resolution ratio is not less than 1mm.Wherein, multi-channel data acquisition board 6 can be defeated using the simulation of 32 tunnels of multiplexing
Enter, transmission speed 500kS/s, 16 bit resolutions, signal amplitude ± 10V, built-in filter and amplification module, it is possible to achieve high pass and low
Pass filter, voltage amplification factor ± 40dB；Host computer 3 uses PC, is provided with corresponding imaging software, can show in real time,
The image that storage and playback are produced based on the photoacoustic signal.
The workflow of the photoacoustic imaging system suitable for peripheral vascular imaging provided below the present invention is illustrated：
Laser 2 launches laser, while launching the first trigger signal to trigger 1, trigger 1 receives described first and touched
Signal the backward transmitting of multi-channel data acquisition board 6 collection signal, and the laser is irradiated to target to be scanned by fibre bundle 41
Photoacoustic signal is produced, ultrasonic transducer 42 receives the photoacoustic signal, and multi-channel data acquisition board 6 receives the collection signal
The photoacoustic signal that collection ultrasonic transducer 42 is received afterwards, and the photoacoustic signal is sent to host computer 3, the basis of host computer 3
The photoacoustic signal carries out tomography or three-dimensional imaging to the target to be scanned.
The photoacoustic imaging system suitable for peripheral vascular imaging that the present invention is provided can be to blood flow, blood oxygen, oxygen metabolism etc.
Important physiological parameter carries out unmarked quantitative high resolution functional imaging, at the same can avoid using contrast agent and X-ray into
As the injury caused to human body.The photoacoustic imaging system suitable for peripheral vascular imaging that the present invention is provided, is sent out by laser
Laser is penetrated, while launching trigger signal to trigger, makes trigger to multi-channel data acquisition board transmitting collection signal, laser leads to
Cross fibre bundle irradiation target to be scanned and produce photoacoustic signal, multi-channel data acquisition board is according to collection signal acquisition ultrasonic transducer
The photoacoustic signal of reception, and photoacoustic signal is transferred to host computer imaging, improve the security and accuracy to blood vessel imaging.
On the basis of the various embodiments described above, further, clamper 43 includes three mounting holes, two of which mounting hole
The one-to-two optical fiber is respectively mounted, another mounting hole installs ultrasonic transducer 42, and described two mounting holes are on described another
One mounting hole is symmetrical arranged.
Specifically, in order to ensure that acousto-optic is coaxial, it is necessary to which the one-to-two optical fiber is symmetrically installed into ultrasonic transducer 42
Both sides, clamper 43 can set three mounting holes, and two of which mounting hole is symmetrical arranged on another mounting hole, described
Another mounting hole is used to ultrasonic transducer 42 is fixedly mounted, and described two mounting holes install the one-to-two optical fiber.
On the basis of the various embodiments described above, further, the system also includes：Trigger 1 and ultrasonic transducer 42
It is connected, ultrasonic transducer 42 is additionally operable to produce and receive ultrasonic signal.
Specifically, ultrasonic transducer 42 can also send ultrasonic signal to the target to be scanned, and wait to sweep described in receiving
The ultrasonic signal of target reflection is retouched, ultrasonic transducer 42 is connected with trigger 1, receiving the ultrasound triggering letter that trigger 1 is sent
After number, the ultrasonic signal is sent.
On the basis of the various embodiments described above, further, laser 2 uses multi-wavelength's pulse laser, for example
The adjustable pulse laser of 532-1064nm multi-wavelengths.The laser of appropriate wavelength is selected to irradiate the target to be scanned successively, profit
With heterogeneity, the absorption coefficient of light is different under the laser irradiation of different wave length, the optoacoustic obtained by the laser excitation of different wave length
Signal is variant, it is hereby achieved that the functional imaging of many kinds of parameters.
On the basis of the various embodiments described above, further, clamper 43 is manufactured using 3D printing technique.
On the basis of the various embodiments described above, further, laser 2 is connected by fiber coupler with fibre bundle 41.
On the basis of the various embodiments described above, further, fibre bundle 41 includes 128 optical fiber.
On the basis of the various embodiments described above, further, ultrasonic transducer 42 is linear array ultrasound transducer.
Fig. 2 is the schematic flow sheet for the acousto-optic imaging method that one embodiment of the invention is applied to peripheral vascular imaging, such as Fig. 2
It is shown, using the acousto-optic imaging method suitable for peripheral vascular imaging of the photoacoustic imaging system described in any of the above-described embodiment,
Including：
S201, laser transmitting laser, while sending the first trigger signal to trigger；
Specifically, after the photoacoustic imaging system described in any of the above-described embodiment is ready to complete progress photoacoustic imaging, open
Laser launches laser, and sends the first trigger signal to trigger.
S202, the trigger, which receive to send to multi-channel data acquisition board after first trigger signal, gathers letter
Number；
Specifically, the trigger can receive first trigger signal, and after first trigger signal is received,
Collection signal is sent to multi-channel data acquisition board.
S203, the laser are irradiated to target to be scanned by the fibre bundle and produce photoacoustic signal；
Specifically, the laser is irradiated in target to be scanned by the fibre bundle being connected with the laser, so as to produce
Third contact of a total solar or lunar eclipse acoustical signal.
S204, ultrasonic transducer receive the photoacoustic signal；
Specifically, after photoacoustic signal generation, the ultrasonic transducer receives the photoacoustic signal.
The light that S205, the multi-channel data acquisition board ultrasonic transducer according to the collection signal acquisition are received
Acoustical signal, and the photoacoustic signal is sent to host computer；
Specifically, the multi-channel data acquisition board can receive the signal of the gathered data, and be adopted described in reception
After the signal for collecting data, photoacoustic signal collection is carried out to the ultrasonic transducer, will be described after the photoacoustic signal is collected
Photoacoustic signal is sent to host computer.
S206, the host computer are imaged based on the photoacoustic signal to the target to be scanned.
Specifically, the host computer is received after the photoacoustic signal, according to backprojection reconstruction algorithm to described to be scanned
Target carries out tomography or three-dimensional imaging.
The acousto-optic imaging method suitable for peripheral vascular imaging that the present invention is provided being capable of the light based on hemoglobin itself
Absorb, physiological parameter important to blood flow, blood oxygen, oxygen metabolism etc. carries out unmarked quantitative high resolution functional imaging, improves
The accuracy of human peripheral blood pipe imaging, while the injury caused using contrast agent and x-ray imaging to human body can be avoided.This hair
The acousto-optic imaging method suitable for peripheral vascular imaging of bright offer, launches laser, while launching to trigger by laser
Trigger signal, makes trigger to multi-channel data acquisition board transmitting collection signal, laser irradiates target to be scanned by fibre bundle
Produce photoacoustic signal, the photoacoustic signal that multi-channel data acquisition board is received according to collection signal acquisition ultrasonic transducer, and by light
Acoustical signal is transferred to host computer imaging, realizes the morphology positioning and functional metabolism imaging of human peripheral blood pipe, improves externally
The security and accuracy of all blood vessel imagings.
Fig. 3 is the flow signal for the multi-modal acousto-optic imaging method that another embodiment of the present invention is applied to peripheral vascular imaging
Figure, as shown in figure 3, on the basis of above-described embodiment, further, what the present invention was provided is applied to many of peripheral vascular imaging
Mode acousto-optic imaging method includes：
S301, laser transmitting laser, while sending the first trigger signal to trigger；
Specifically, after the photoacoustic imaging system described in any of the above-described embodiment is ready to complete progress photoacoustic imaging, open
Laser launches laser, and sends the first trigger signal to trigger.
S302, the trigger, which receive to send to multi-channel data acquisition board after first trigger signal, gathers letter
Number, and after the collection signal preset time is sent, the second trigger signal is sent to ultrasonic transducer；
Specifically, the trigger can receive first trigger signal, and receive first trigger signal
Afterwards, collection signal is sent to multi-channel data acquisition board, after the collection signal preset time is sent, is sent out to ultrasonic transducer
Send the second trigger signal.Wherein, the preset time is configured according to actual conditions, and the embodiment of the present invention is not limited.
S303, the laser are irradiated to target to be scanned by fibre bundle and produce photoacoustic signal；
Specifically, the laser is irradiated in target to be scanned by the fibre bundle being connected with the laser, so as to produce
Third contact of a total solar or lunar eclipse acoustical signal.
S304, the ultrasonic transducer receive the photoacoustic signal；After second trigger signal is received, to waiting to sweep
Objective emission ultrasonic signal is retouched, and receives the ultrasonic signal of reflection；
Specifically, after photoacoustic signal generation, the ultrasonic transducer receives the photoacoustic signal.The ultrasonic transducer
Second trigger signal can be received, and after second trigger signal is received, ultrasound is launched to the target to be scanned
Signal.The target to be scanned can be reflected the ultrasonic signal, and the ultrasonic transducer can receive reflection
Ultrasonic signal.
The institute that S305, the multi-channel data acquisition board ultrasonic transducer according to the collection signal acquisition are received
The ultrasonic signal of photoacoustic signal and the reflection is stated, and the ultrasonic signal of the photoacoustic signal and the reflection is sent to upper
Machine；
Specifically, the multi-channel data acquisition board receives the collection signal, and after the collection signal is received, it is right
The ultrasonic transducer carries out the collection of the photoacoustic signal and the ultrasonic signal of the reflection, and by the optoacoustic collected
Signal and the ultrasonic signal of the reflection are sent to host computer.
S306, ultrasonic signal of the host computer based on the photoacoustic signal and the reflection enter to the target to be scanned
Row multi-modality imaging.
Specifically, the host computer is received after the ultrasonic signal of the photoacoustic signal and the reflection, can be according to institute
The ultrasonic signal for stating reflection carries out localization by ultrasonic to the target to be scanned, and carries out high-resolution work(according to the photoacoustic signal
It can be imaged, so as to realize to the multispectral bimodal tomography of the target to be scanned or three-dimensional imaging.The host computer may be used also
So that the image of the ultrasonic imaging and the photoacoustic imaging to be merged.
The multi-modal acousto-optic imaging method suitable for peripheral vascular imaging that the present invention is provided, at the same using ultrasonic signal and
Photoacoustic signal is imaged to target to be scanned, is conducive to the quick spatial distribution for obtaining target to be scanned and is carried out morphology standard
It is determined that position.
The idiographic flow of the inventive method embodiment is referred to the introduction of above-mentioned each system embodiment, no longer goes to live in the household of one's in-laws on getting married herein
State.
Through the above description of the embodiments, those skilled in the art can be understood that each embodiment can
Realized by the mode of software plus required general hardware platform, naturally it is also possible to pass through hardware.Understood based on such, on
The part that technical scheme substantially in other words contributes to prior art is stated to embody in the form of software product, should
Computer software product can be stored in a computer-readable storage medium, such as ROM/RAM, magnetic disc, CD, including some fingers
Order is to cause a computer equipment (can be personal computer, server, or network equipment etc.) to perform each implementation
Method described in some parts of example or embodiment.
Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
The present invention is described in detail with reference to the foregoing embodiments, it will be understood by those within the art that：It still may be used
To be modified to the technical scheme described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic；
And these modification or replace, do not make appropriate technical solution essence depart from various embodiments of the present invention technical scheme spirit and
Scope.
Claims (10)
1. a kind of photoacoustic imaging system suitable for peripheral vascular imaging, it is characterised in that including：
Trigger, laser, scanning head, mechanical arm, multi-channel data acquisition board and host computer, wherein：
The trigger is connected with the laser and the multi-channel data acquisition board respectively；The scanning head includes optical fiber
Beam, ultrasonic transducer and clamper, the fibre bundle include multifiber, one end of the fibre bundle and the laser phase
Even, the average one-to-two of the other end is symmetrically fixed on the both sides of the ultrasonic transducer by the clamper, to realize that acousto-optic is total to
Axle；The laser that the fibre bundle is used to produce in the laser is irradiated to target to be scanned generation photoacoustic signal, the ultrasound
Transducer is used to receive the photoacoustic signal；The scanning head is removably mounted on the mechanical arm, the mechanical arm
For driving the scanning head to be scanned the target to be scanned；The multi-channel data acquisition board surpasses with described respectively
Sonic transducer is connected with the host computer.
2. system according to claim 1, it is characterised in that the clamper includes three mounting holes, two of which peace
Dress hole is respectively mounted the one-to-two optical fiber, and another mounting hole installs the ultrasonic transducer, described two mounting holes on
Another described mounting hole is symmetrical arranged.
3. system according to claim 1, it is characterised in that also include：The trigger and the ultrasonic transducer phase
Even, the ultrasonic transducer is additionally operable to produce and receive ultrasonic signal.
4. system according to claim 1, it is characterised in that the laser uses multi-wavelength's pulse laser.
5. system according to claim 1, it is characterised in that the clamper is manufactured using 3D printing technique.
6. system according to claim 1, it is characterised in that the laser passes through fiber coupler and the fibre bundle
It is connected.
7. system according to claim 1, it is characterised in that the fibre bundle includes 128 optical fiber.
8. the system according to any one of claim 1 to 7, it is characterised in that the ultrasonic transducer is super for linear array
Sonic transducer.
9. a kind of light suitable for peripheral vascular imaging of photoacoustic imaging system using as described in any one of claim 1 to 8
Acoustic imaging method, it is characterised in that including：
Laser launches laser, while sending the first trigger signal to trigger；
The trigger, which receives to send to multi-channel data acquisition board after first trigger signal, gathers signal；
The laser is irradiated to target to be scanned by the fibre bundle and produces photoacoustic signal；
Ultrasonic transducer receives the photoacoustic signal；
The photoacoustic signal that multi-channel data acquisition board ultrasonic transducer according to the collection signal acquisition is received, and
The photoacoustic signal is sent to host computer；
The host computer is imaged based on the photoacoustic signal to the target to be scanned.
10. a kind of photoacoustic imaging system using as described in any one of claim 1 to 8 suitable for many of peripheral vascular imaging
Mode acousto-optic imaging method, it is characterised in that including：
Laser launches laser, while sending the first trigger signal to trigger；
The trigger, which receives to send to multi-channel data acquisition board after first trigger signal, gathers signal, and is sending
After the collection signal preset time, the second trigger signal is sent to ultrasonic transducer；
The laser is irradiated to target to be scanned by fibre bundle and produces photoacoustic signal；
The ultrasonic transducer receives the photoacoustic signal；After second trigger signal is received, sent out to target to be scanned
Ultrasonic signal is penetrated, and receives the ultrasonic signal of reflection；
The optoacoustic letter that multi-channel data acquisition board ultrasonic transducer according to the collection signal acquisition is received
Number and the reflection ultrasonic signal, and the ultrasonic signal of the photoacoustic signal and the reflection is sent to host computer；
Ultrasonic signal of the host computer based on the photoacoustic signal and the reflection carries out multi-modal to the target to be scanned
Imaging.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710374235.0A CN107174208A (en) | 2017-05-24 | 2017-05-24 | A kind of photoacoustic imaging system and method suitable for peripheral vascular imaging |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710374235.0A CN107174208A (en) | 2017-05-24 | 2017-05-24 | A kind of photoacoustic imaging system and method suitable for peripheral vascular imaging |
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