CN107137168B - Degradable recoverable 4D prints the organic human body support of line style and its application method - Google Patents
Degradable recoverable 4D prints the organic human body support of line style and its application method Download PDFInfo
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- CN107137168B CN107137168B CN201710476842.8A CN201710476842A CN107137168B CN 107137168 B CN107137168 B CN 107137168B CN 201710476842 A CN201710476842 A CN 201710476842A CN 107137168 B CN107137168 B CN 107137168B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/041—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2002/9528—Instruments specially adapted for placement or removal of stents or stent-grafts for retrieval of stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
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Abstract
The organic human body support of line style is printed the present invention relates to a kind of degradable recoverable 4D and its application method, human body support include: spire and mounting ring；Wherein, mounting ring is at least set to one end of spire, and mounting ring is equipped with fixation hole；Spire includes several sequentially connected spiral elements.Each spiral element includes circumference unit and several support units；The shape of support unit is that axially parallel arch is swelled with human body support；The shape of circumference unit is spiral shape.Human body support provided by the invention can achieve the effect that fix in the blood vessel in the case where not damaging blood vessel, not increasing accessory fixture；And the people's body support frame can facilitate taking-up in a short time, and can effectively degrade in the long-term use, it is with a wide range of applications.In addition, human body support provided by the invention will not generate stimulation to vascular wall in use, and facilitate taking-up, effectively reduces the pain of patient.
Description
Technical field
The present invention relates to human body support's technical fields, and in particular to a kind of degradable recoverable 4D printing organic human body of line style
Bracket and its application method.
Background technique
Shown according to the data of " China Health statistics summary ": China's Patients with Cardiovascular/Cerebrovascular Diseases alreadys exceed 2.7 at present
Hundred million people, cardiovascular and cerebrovascular disease cause death toll to have been approached the 40% of national total toll, already become the " head of compatriots' health
Number killer ".The Etiological of cardiovascular disease is that superabundant fats substance and calcium are allowed to thicken in vascular wall deposition, causes blood vessel
Narrow or block and cause blood circulation difficult, and then generates angina pectoris, myocardial infarction until dead.So far, the heart is fought
The main means of vascular diseases are Jie that special bracket insertion diseased region is carried out to diagnosing and treating using percutaneous puncture approach
Enter cure: its principle is the blood vessel that stenter to implant has narrowed, so that a lasting radial pressure is generated to inner wall,
It forces the deposit being attached on vascular wall to be concentrated and supports it and make unobstructed blood vessel.
For intravascular stent, people have carried out many researchs: the first generation is balloon expandable, it is by the blood vessel ball of blocking
Capsule is propped up；But due to that can collapse quickly, appearance is narrow again, and Acute vessel closure can occur for some patients；Second
In generation, appears in last century the nineties, and doctor's is stainless steel mesh bracket, although this technology avoids that blood vessel is acute to be closed
Plug and part restenosis, but the appearance of metallic foreign body can accelerate the growth of scar tissue, and restenosis occurs or even can block up completely
Fill in coronary artery；The beginning of this century has doctor to coat drug on " naked " bracket and implants again, and bracket for eluting medicament of new generation is big
Restenosis is reduced greatly, but the histoincompatiblity of drug stent surface covering can generate local inflammation stimulation, to induce
Generate thrombus.Traditional intravascular stent mostly uses metal material to be prepared greatly, non-degradable.For example, Chinese patent
201410266420.4 disclosing a kind of intravascular stent: being made of nondegradable metal material.It is implanted into such metallic blood vessel branch
The patient of frame cannot do nuclear magnetic resonance, will cause blood vessel endothelium hyperplasia formed it is secondary narrow；In addition, intravascular stent general some months
The mission of its support blood vessels can be completed, blood vessel restores normal thereafter, and no longer needs intravascular stent, to implant not
Can the patient of intravascular stent of degradation can face secondary narrow risk, once occur it is secondary it is narrow once must receive heart pass
Pain.Chinese patent 200820006963.2, which discloses, a kind of by conduit and automatically springs open the tubular blood vessel that type stent source constitutes
Bracket, and be once implanted into, it can not be easily removed in a short time.Based on this, it is particularly important to research and develop a novel intravascular stent.
In addition to intravascular stent, same problem is also faced in the human body supports such as intestinal stent, biliary tract prosthesis field.
Summary of the invention
For the defects in the prior art, the present invention is intended to provide a kind of degradable recoverable 4D prints the organic human body of line style
Bracket and its application method.Human body support provided by the invention can be in the feelings that do not damage blood vessel, do not increase accessory fixture
Under condition, achieve the effect that fix in the blood vessel；And the people's body support frame can facilitate taking-up in a short time, and in long-term use process
In can effectively degrade, be with a wide range of applications.In addition, human body support provided by the invention in use will not be right
Vascular wall generates stimulation, and facilitates taking-up, effectively reduces the pain of patient.
For this purpose, the invention provides the following technical scheme:
In a first aspect, the present invention provides a kind of human body support, comprising: spire and mounting ring；Wherein, mounting ring is at least set
It is placed in one end of spire, and mounting ring is equipped with fixation hole；Spire includes several sequentially connected spiral elements.
In further embodiment of the invention, each spiral element includes circumference unit and several support units；Branch
The shape of support unit is that axially parallel arch is swelled with human body support；The shape of circumference unit is spiral shape.
In further embodiment of the invention, the quantity of support unit is even number on each spiral element；Support is single
Member is evenly distributed on circumference unit, and two neighboring support unit is contrary.
In further embodiment of the invention, the quantity of support unit is 4 on each spiral element, and adjacent two
The interval angles of a support unit are 90 degree.
In further embodiment of the invention, the quantity of support unit is 6 on each spiral element, and adjacent two
The interval angles of a support unit are 60 degree.
In further embodiment of the invention, one end of the spire is provided with mounting ring, and the other end is provided with
Protrusion, and the protrusion is in drops.The setting of drop-like bulge can make human body support avoid puncturing blood in use
Pipe.
In further embodiment of the invention, the shape of the axial line of support unit includes sinusoidal waveform, arc, U
Shape is parabola shaped.
In further embodiment of the invention, chamfering is equipped between mounting ring and spire；Support unit and circumference
Chamfering is equipped between unit.
In further embodiment of the invention, mounting ring is by being formed after a support unit and circumference unit closure
's.
In further embodiment of the invention, mounting ring is the end overstriking of spire and apertured formation.Specifically
Ground, the amplitude of overstriking are between 1~5 times of spire diameter and are all possible.Human body support of the invention can be used for blood
The support of pipe, pancreatic duct, bile duct, enteron aisle, ureter, oesophagus or nasal cavity.
In further embodiment of the invention, each component of human body support is all made of degradation material and is prepared.
Specifically, each component of human body support includes skeleton portion, functional protein film and chitosan film；The Surface mulch in the skeleton portion
The functional protein film, the Surface mulch of the functional protein film the chitosan film；The skeleton portion is using left-handed poly-
Lactic acid, dextrorotation polylactic acid and carboxymethyl chitosan are prepared.
Second aspect, the present invention provide the application method of human body support a kind of, and human body support walks when removed, including as follows
It is rapid: S101: the conduit for being installed with hook-shaped seal wire being inserted at human body support；Wherein, hook-shaped seal wire includes bar portion and is connected to bar
The hook portion of portion one end, the shape of bar portion are a shapes, and the shape of hook portion is spiral shape, the axial line of bar portion and the spiral axle center of hook portion
Line is overlapped；S102: the free end of hook portion is buckled into the mounting ring of human body support, and the hand of spiral along hook portion rotates hook-shaped seal wire
Bar portion so that hook portion passes completely through mounting ring, and mounting ring is set in the junction of bar portion and hook portion；S103: bar portion is pulled
To drive human body support to be detached from vascular wall, the human body support being straightened later enters conduit；S104: when human body support passes through conduit
After removing in vitro, conduit is removed.
In further embodiment of the invention, the diameter of hook portion is less than the diameter of pipe inner wall, tool in hook-shaped seal wire
Body, the diameter of hook portion is 0.5~0.7 times of the fixed hole diameter of mounting ring in hook-shaped seal wire.
In use, installation method installs phase with traditional conduit, seal wire balloon expandable to the present inventor's body support frame
Together；Specifically: (1) with special needle in arm or the big vascular puncture of thigh；The pin hole is unique body surface wound in surgical procedure
Mouthful；(2) it is put into seal wire along needle, this hour hand can exit, to keep seal wire in blood vessel；(3) it is put into and leads along seal wire
Pipe, seal wire guiding catheter enter the coronary artery on heart；(4) sacculus for being wrapped in human body support is put into along conduit；(5) it gives
Inflated, balloon expandable make human body support's deformation prop up；(6) sacculus, conduit and seal wire are withdrawn from.
Above-mentioned technical proposal provided by the invention has the advantage that
(1) applicant has found by many experiments: human body support provided by the invention can not damage blood vessel, not increase
In the case where accessory fixture, achieve the effect that fix in the blood vessel；And can be easily removed, have a wide range of applications valence
Value；In addition, human body support provided by the invention will not generate stimulation to vascular wall, the pain of patient is effectively reduced.
(2) human body support of the invention is easy to take out and be prepared using degradable material, to make it in implantation receptor
When blood vessel:, can be very easily for one, the check discovery inappropriate patient in human body support position interior for two weeks after operation
It takes out again；After human body support's implantation provided by the invention in two weeks, merged not yet with human body support based on histocyte, such as
Fruit finds that the position of human body support is improper, takes out with can be convenient；Secondly, for needing long term support and without the trouble of any discomfort
Person, because human body support of the invention is prepared using degradation material, the human body support to implant can be slow
Degradation, to eliminate the pain that the secondary narrow rear operation of patient is put up a bridge.
(3) human body support of the invention is prepared using polylactic acid and chitosan, because polylactic acid and chitosan have
There is good human compatibility, rejection will not occur；Chitosan, polylactic acid, protein can be decomposed or be degraded in vivo,
To eliminate the pain that the secondary narrow surgical of patient is put up a bridge；In addition, functional protein can play the role of melting thrombus,
With human body friendly；The deformation ratio wire of 4D printed material will not generate stimulation to vascular wall；Therefore, the present invention provides
Human body support be with a wide range of applications.
(4) human body support provided by the invention in the specific use process, can carry out machine to narrow coronary artery
Tool support, while drug is discharged, prevent restenosis；And the blood vessel of blocking, after bracket supports 6 months, human body vis medicatrix naturae is just
Can help to restore the elasticity of blood vessel, after-poppet slowly degrade up to being absorbed by tissue completely, blood vessel structure and function are completely extensive
Again to nature.
(5) it is well known that high-incidence area of the coronary artery as thrombus on heart, common coronary artery blood vessel in surgical procedure
Bracket once misplaces or occurs positional shift, can only just be saved by open chest surgery；Therefore, use is provided by the invention
Safely removing for human body support can be realized by special needle in arm or the big vascular puncture of thigh in human body support, has wide
General application value.
Additional aspect and advantage of the invention will be set forth in part in the description, and will partially become from the following description
Obviously, or practice through the invention is recognized.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of a spiral element of the present inventor's body support frame；
Fig. 2 is the structural schematic diagram of human body support in the embodiment of the present invention one；
Fig. 3 is the structural schematic diagram of human body support in the embodiment of the present invention two；
Fig. 4 is the structural schematic diagram of the hook-shaped seal wire of the present invention；
Fig. 5 is the structural schematic diagram that the present inventor's body support frame removes process；
Fig. 6 is the structural schematic diagram of human body support in the embodiment of the present invention five.
In figure:
1, circumference unit；2, support unit；3, mounting ring；4, fixation hole；5, raised；
6, bar portion；7, hook portion；8, conduit；9, spire.
Specific embodiment
The embodiment of technical solution of the present invention will be described in detail below.Following embodiment is only used for clearer
Illustrate technical solution of the present invention, therefore be only used as example, and not intended to limit the protection scope of the present invention.
Experimental method in following embodiments is unless otherwise specified conventional method.
Test material as used in the following examples is unless otherwise specified to be commercially available from conventional reagent shop.
Quantitative test in following embodiment, is respectively provided with three repeated experiments, and data are the average value of three repeated experiments
Or mean+SD.
The present invention provides a kind of human body support, as shown in Figures 2 and 3, comprising: spire 9 and mounting ring 3；Wherein, it installs
Ring 3 is at least set to one end of spire 9, and mounting ring 3 is equipped with fixation hole 4；Spire 9 includes several sequentially connected spiral shells
Revolve unit.The setting of mounting ring 3 and fixation hole 4 can make human body support's easily implantation and removal in subsequent use process,
To effectively reduce the pain of patient.Specifically, Fig. 2 is human body support's structural schematic diagram that both ends are mounting ring 3, to make
It obtains human body support during the installation process, can be carried out from both direction.
Preferably, as shown in Figure 1, each spiral element includes circumference unit 1 and several support units 2；Support unit 2
Shape is that axially parallel arch is swelled with human body support；The shape of circumference unit 1 is spiral shape.To enable human body support
In the case where not damaging blood vessel, not increasing accessory fixture, achieve the effect that fix in the blood vessel.
Preferably, the quantity of support unit 2 is even number on each spiral element；Support unit 2 is evenly distributed in circumference
On unit 1, and two neighboring support unit 2 is contrary.
Preferably, one end of the spire 9 is provided with mounting ring 3, and the other end is provided with protrusion 5, and described raised 5 are in
Drops；Blood vessel is punctured during the installation process as shown in figure 3, the presence of drop-like bulge 5 avoids human body support.
Preferably, the shape of the axial line of support unit 2 includes sinusoidal waveform, arc, U-shaped or parabola shaped.
Preferably, chamfering is equipped between mounting ring 3 and spire 9；Chamfering is equipped between support unit 2 and circumference unit 1.
The setting of chamfering, which can effectively reduce, can also play the stress concentration phenomenon reduced in human body support's use process, and can reinforce
The intensity of human body support.
Preferably, mounting ring 3 is formed after being closed by a support unit 2 and circumference unit 1.
Preferably, the mounting ring 3 is end overstriking and the apertured formation of spire 9.
It is illustrated With reference to embodiment:
Embodiment one
The present invention provides a kind of human body support, as shown in Figure 2, comprising: the protrusion 5 of spire 9, mounting ring 3 and water-drop-shaped；
Wherein, mounting ring 3 is set to one end of spire 9, and mounting ring 3 is equipped with fixation hole 4；The protrusion 5 of water-drop-shaped is set to spiral shell
The other end in rotation portion 9；Spire 9 includes several sequentially connected spiral elements, and each spiral element includes spiral circumference
Unit 1 and 4 support unit 2, i.e., the quantity of support unit 2 is 4 on each spiral element, two neighboring support unit 2
Interval angles are 90 degree, and the shape of support unit 2 is that axially parallel arch is swelled with human body support, and two neighboring support is singly
Member 2 it is contrary, the shape of 2 axial line of support unit is sinusoidal waveform.
Embodiment two
The present invention provides a kind of human body support, as shown in Figure 3, comprising: spire 9 and mounting ring 3；Wherein, mounting ring 3 is set
The both ends of spire 9 are placed in, and mounting ring 3 is equipped with fixation hole 4；Spire 9 includes several sequentially connected spiral elements, often
A spiral element includes spiral circumference unit 1 and 6 support unit 2, i.e., the quantity of support unit 2 on each spiral element
It is 6, the interval angles of two neighboring support unit 2 are 60 degree, and the shape of support unit 2 is axially parallel with human body support
Arch protuberance, and two neighboring support unit 2 is contrary, the shape of 2 axial line of support unit is sinusoidal waveform.
Embodiment three
It is directed to human body support provided by the invention as shown in Figure 4, Figure 5, the present invention specially devises application method:
Specifically, the installation of installation method and traditional conduit 8, seal wire balloon expandable when the present inventor's body support frame uses
Method is identical；Specifically: (1) with special needle in arm or the big vascular puncture of thigh；The pin hole is unique in surgical procedure
Surface wound；(2) it is put into seal wire along needle, this hour hand can exit, to keep seal wire in blood vessel；(3) along seal wire
It is put into conduit 8, seal wire guiding catheter 8 enters the coronary artery on heart；(4) it is put into along conduit 8 and is wrapped in human body support's
Sacculus；(5) inflated is given, balloon expandable makes human body support's deformation prop up；(6) sacculus, conduit 8 and seal wire are withdrawn from.
In addition, human body support of the invention is when removed, include the following steps:
S101: the conduit 8 for being installed with hook-shaped seal wire is inserted at human body support；Wherein, hook-shaped seal wire as shown in figure 4,
Wherein, (a) is the stereoscopic schematic diagram of hook-shaped seal wire, (b) is the left view of hook-shaped seal wire, (c) is the main view of hook-shaped seal wire；Hook
Shape seal wire includes bar portion 6 and the hook portion 7 for being connected to 6 one end of bar portion, and the shape of bar portion 6 is a shape, and the shape of hook portion 7 is spiral
Shape, the axial line of bar portion 6 are overlapped with the spiral axial line of hook portion 7；The diameter of hook portion 7 is less than the diameter of 8 inner wall of conduit, and hook-shaped
The diameter of hook is 0.5~0.7 times of 4 diameter of fixation hole of mounting ring 3 in seal wire.S102: as shown in figure 5, by the freedom of hook portion 7
End buckles into the mounting ring 3 of human body support, and the bar portion 6 of hook-shaped seal wire is rotated along the hand of spiral of hook portion 7, so that hook portion 7 is complete
Across mounting ring 3, and mounting ring 3 is set in the junction of bar portion 6 Yu hook portion 7.S103: pull bar portion 6 to drive human body support
It is detached from vascular wall, the human body support being straightened later enters conduit 8.S104: after human body support removes external by conduit 8,
Remove conduit 8.It is found for the inappropriate patient in human body support position hence for check in two weeks after operation, it can be very convenient
Taking-up again.
Example IV
As shown in figure 3, a kind of present invention provides its body shape structure of human body support, difference identical as embodiment two
It is, the present embodiment mounting ring 3 is the end overstriking of spire 9 and apertured formation.
Embodiment five
As shown in fig. 6, a kind of present invention provides its body shape structure of human body support, difference identical as embodiment two
It is, the present embodiment mounting ring 3 is formed after being closed by a support unit 2 and circumference unit 1.
In addition, each component is all made of degradation material and is prepared for human body support of the invention.Specifically, human body
Each component of bracket includes skeleton portion, functional protein film and chitosan film；The Surface mulch in skeleton portion functional protein film, function
The Surface mulch of protein film chitosan film；Skeleton portion is using l-lactic acid, dextrorotation polylactic acid and carboxymethyl chitosan system
It is standby to form.The human body support of structure of the invention is prepared and had for thus material, is commented by function assessment test come system
Its effect of valence:
One, platelet adhesion test
It is well known that platelet adhesion reaction, deformation and aggregation etc. can be caused a series of when biological medicine material and contacting blood
Variation, so that material surface be made to form thrombus；The adherency city degree of test blood platelet on the surface of the material is evaluation medical material blood
The important means of compatibility.It is recorded according in " Liang Dongke: the processing of endovascular stent and its analysis and evaluation of mechanical property "
Method tested.
Specifically, by after fresh anticoagulant people's blood centrifugation 10min, top platelet rich plasma is taken, sample is soaked into 37 DEG C
Blood platelet liquid in take out after 1h, rinsed through physiological salt liquid, 2.5% glutaraldehyde fixer is fixed, then by the dehydration of alcohol series,
Isoamyl acetate dealcoholysis sprays silver after critical point drying, observes platelet PLA2 under scanning electron microscope.
Experiment discovery: the platelet counts of the present inventor's body support frame surface adhesion are seldom, and the blood platelet adhered to is disk
Shape and no pseudopodium, platelet very little.Thus illustrate, human body support provided by the invention has excellent blood compatibility
Property.
Two, the present inventor's body support frame radial mechanical performance is tested
According to the method recorded in " Wan Min: human body support's physical and mechanical property experimental study ", the anti-of human body support is measured
Extrusion performance.Specifically, the human body support of 3.0mm under nominal pressure of the invention is loaded on sacculus dilating catheter 8,37
Stablize 30s or more in DEG C ± 1 DEG C of water-bath, is then filled to nominal diameter 3.0mm respectively, withdraw from sacculus dilating catheter 8, it will
Human body support after release is placed between the two parallel plates up and down of puller system, and parallel flat length ensures to be more than test human body
The length of bracket at the uniform velocity compresses the deflection (1.5mm) of human body support to 50%, then proceedes to compression until human body support reaches
Maximum allowable displacement stops experiment at this time, records data, as shown in table 1.
1 the present inventor's body support frame radial mechanical performance data list of table
Three, clinical test
Human body support provided by the invention is used in treatment clinical course, specifically, call-up age 18~60 years old hat
Cardiaopath 100, the angiography stenosis of each patient is 70% or more, or is accompanied by serious angina pectoris or the heart
Flesh infarct etc. needs to be implanted into bracket.Each patient is divided into 2 groups, tries out the human body support of embodiment one and embodiment two respectively；
Later after the implants 2 weeks and 1 year when by paying a return visit the trial state of assessment human body support, specific data are as shown in table 2.
Judgment criteria:
Excellent: patient fits symptom invariably after implantation, and feels without traction etc.；Good: there is appropriateness discomfort in patient, such as leads
It opens, feel suffocated；Invalid: still there are the symptoms such as expiratory dyspnea, pectoralgia in patient.
2 the present inventor's body support frame clinical testing data list of table
Certainly, the case where being enumerated in addition to embodiment one and embodiment two, the other parameter settings etc. of human body support's structure
It is possible.
Human body support provided by the invention can reach in the case where not damaging blood vessel, not increasing accessory fixture
Fixed effect in the blood vessel；And can be easily removed, it is with a wide range of applications；In addition, human body provided by the invention
Bracket will not generate stimulation to vascular wall in use, and facilitate taking-up, effectively reduce the pain of patient.
In the description of the present invention, it is to be understood that, term " center ", " longitudinal direction ", " transverse direction ", " axial direction ", " radial direction ",
The orientation or positional relationship of instructions such as " circumferential directions " is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of description originally
Invention and simplified description, rather than the device or element of indication or suggestion meaning must have a particular orientation, with specific side
Position construction and operation, therefore be not considered as limiting the invention.
In the description of the present invention, the meaning of " plurality " is two or more, unless otherwise specifically defined.In this hair
In bright unless specifically defined or limited otherwise, the terms such as term " installation ", " connected ", " connection ", " fixation " should do broad sense reason
Solution, for example, it may be being fixedly connected, may be a detachable connection, or integral；It can be mechanical connection, be also possible to electricity
Connection；It can be directly connected, the connection inside two elements or two can also be can be indirectly connected through an intermediary
The interaction relationship of element.For the ordinary skill in the art, above-mentioned term can be understood as the case may be
Concrete meaning in the present invention.
In the description of the present invention, it is to be understood that, term " first ", " second " are used for description purposes only, and cannot
It is interpreted as indication or suggestion relative importance or implicitly indicates the quantity of indicated technical characteristic.Define as a result, " the
One ", the feature of " second " can explicitly or implicitly include one or more of the features.In the description of the present invention,
The meaning of " plurality " is two or more, unless otherwise specifically defined.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office
It can be combined in any suitable manner in one or more embodiment or examples.In addition, without conflicting with each other, the skill of this field
Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples
It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, modifies, replacement and variant.
Claims (1)
1. a kind of human body support characterized by comprising spire and mounting ring；
Wherein, the mounting ring is at least set to one end of the spire, and the mounting ring is equipped with fixation hole；The spiral shell
Rotation portion includes several sequentially connected spiral elements；
Each spiral element includes circumference unit and several support units；The shape of the support unit is and the human body
The axial parallel arch protuberance of bracket；The shape of the circumference unit is spiral shape；
And the quantity of support unit is even number on each spiral element；The support unit is evenly distributed in the circumference
On unit, and the two neighboring support unit is contrary；
The quantity of support unit is 4 on each spiral element, and the interval angles of the two neighboring support unit are
90 degree；Or, the quantity of support unit is 6 on each spiral element, and the angular interval of the two neighboring support unit
Degree is 60 degree；One end of the spire is provided with mounting ring, and the other end is provided with protrusion, and the protrusion is in drops；
The shape of the axial line of the support unit includes sinusoidal waveform, arc, U-shaped or parabola shaped；
Chamfering is equipped between the mounting ring and the spire；It is equipped between the support unit and the circumference unit
Angle；
Each component of the human body support is all made of degradation material and is prepared；
The human body support is used for the support of blood vessel, pancreatic duct, bile duct, enteron aisle, ureter, oesophagus or nasal cavity；
The mounting ring is by being formed after a support unit and circumference unit closure；Or the mounting ring is the end of spire
What portion's overstriking and apertured were formed.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710476842.8A CN107137168B (en) | 2017-06-21 | 2017-06-21 | Degradable recoverable 4D prints the organic human body support of line style and its application method |
| PCT/CN2017/090766 WO2018232772A1 (en) | 2017-06-21 | 2017-06-29 | Degradable and withdrawable 4d printing linear organic human body stent and using method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710476842.8A CN107137168B (en) | 2017-06-21 | 2017-06-21 | Degradable recoverable 4D prints the organic human body support of line style and its application method |
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| Publication Number | Publication Date |
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| CN107137168A CN107137168A (en) | 2017-09-08 |
| CN107137168B true CN107137168B (en) | 2019-07-05 |
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| CN201710476842.8A Active CN107137168B (en) | 2017-06-21 | 2017-06-21 | Degradable recoverable 4D prints the organic human body support of line style and its application method |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN107137168B (en) |
| WO (1) | WO2018232772A1 (en) |
Families Citing this family (2)
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|---|---|---|---|---|
| CN108969165B (en) * | 2018-06-13 | 2020-08-07 | 哈尔滨工业大学 | 4D printing shape memory polymer composite material tracheal stent and preparation method thereof |
| CN114305817B (en) * | 2022-03-14 | 2022-05-27 | 杭州亿科医疗科技有限公司 | Anti-collapse intravascular stent |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2695012Y (en) * | 2004-04-02 | 2005-04-27 | 北京美中双和医疗器械有限公司 | Lattice type blood resel dilator |
| CN101553188A (en) * | 2006-10-23 | 2009-10-07 | 安森医学有限公司 | Helical stent graft |
| CN101636126A (en) * | 2007-01-19 | 2010-01-27 | 万能医药公司 | Endoprostheses with supporting member |
| CN102227194A (en) * | 2008-10-06 | 2011-10-26 | 灵活支架解决方案股份有限公司 | Reconstrainable stent delivery system |
| CN103841929A (en) * | 2011-09-28 | 2014-06-04 | 伊西康公司 | Negative pressure intestinal anastomosis protection devices |
| CN104116578A (en) * | 2014-07-18 | 2014-10-29 | 西安交通大学 | Method for forming artificial vascular stent through 4D printing |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3868956A (en) * | 1972-06-05 | 1975-03-04 | Ralph J Alfidi | Vessel implantable appliance and method of implanting it |
| US5591230A (en) * | 1994-09-07 | 1997-01-07 | Global Therapeutics, Inc. | Radially expandable stent |
| WO1996026682A1 (en) * | 1995-02-27 | 1996-09-06 | Instent, Inc. | Hollow stent |
| WO2002071980A2 (en) * | 2001-03-09 | 2002-09-19 | Georgia Tech Research Corporation | Intravascular device and method for axially stretching blood vessels |
| US6585753B2 (en) * | 2001-03-28 | 2003-07-01 | Scimed Life Systems, Inc. | Expandable coil stent |
| DE20312722U1 (en) * | 2002-08-14 | 2003-11-06 | Strecker Ernst Peter | Mäanderstent |
| US20050131515A1 (en) * | 2003-12-16 | 2005-06-16 | Cully Edward H. | Removable stent-graft |
| US7766960B2 (en) * | 2004-04-30 | 2010-08-03 | Novostent Corporation | Delivery catheter that controls foreshortening of ribbon-type prostheses and methods of making and use |
| US7942917B2 (en) * | 2009-04-17 | 2011-05-17 | Medtronic Vascular, Inc. | Hollow helical stent system |
-
2017
- 2017-06-21 CN CN201710476842.8A patent/CN107137168B/en active Active
- 2017-06-29 WO PCT/CN2017/090766 patent/WO2018232772A1/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2695012Y (en) * | 2004-04-02 | 2005-04-27 | 北京美中双和医疗器械有限公司 | Lattice type blood resel dilator |
| CN101553188A (en) * | 2006-10-23 | 2009-10-07 | 安森医学有限公司 | Helical stent graft |
| CN101636126A (en) * | 2007-01-19 | 2010-01-27 | 万能医药公司 | Endoprostheses with supporting member |
| CN102227194A (en) * | 2008-10-06 | 2011-10-26 | 灵活支架解决方案股份有限公司 | Reconstrainable stent delivery system |
| CN103841929A (en) * | 2011-09-28 | 2014-06-04 | 伊西康公司 | Negative pressure intestinal anastomosis protection devices |
| CN104116578A (en) * | 2014-07-18 | 2014-10-29 | 西安交通大学 | Method for forming artificial vascular stent through 4D printing |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107137168A (en) | 2017-09-08 |
| WO2018232772A1 (en) | 2018-12-27 |
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