CN107049604A - Intelligent adhesive bandage - Google Patents
Intelligent adhesive bandage Download PDFInfo
- Publication number
- CN107049604A CN107049604A CN201710336787.2A CN201710336787A CN107049604A CN 107049604 A CN107049604 A CN 107049604A CN 201710336787 A CN201710336787 A CN 201710336787A CN 107049604 A CN107049604 A CN 107049604A
- Authority
- CN
- China
- Prior art keywords
- adhesive bandage
- probe
- blood
- intelligent
- thorn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0203—Adhesive plasters or dressings having a fluid handling member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L21/00—Processes or apparatus adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof
- H01L21/02—Manufacture or treatment of semiconductor devices or of parts thereof
- H01L21/027—Making masks on semiconductor bodies for further photolithographic processing not provided for in group H01L21/18 or H01L21/34
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L21/00—Processes or apparatus adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof
- H01L21/02—Manufacture or treatment of semiconductor devices or of parts thereof
- H01L21/04—Manufacture or treatment of semiconductor devices or of parts thereof the devices having at least one potential-jump barrier or surface barrier, e.g. PN junction, depletion layer or carrier concentration layer
- H01L21/18—Manufacture or treatment of semiconductor devices or of parts thereof the devices having at least one potential-jump barrier or surface barrier, e.g. PN junction, depletion layer or carrier concentration layer the devices having semiconductor bodies comprising elements of Group IV of the Periodic System or AIIIBV compounds with or without impurities, e.g. doping materials
- H01L21/30—Treatment of semiconductor bodies using processes or apparatus not provided for in groups H01L21/20 - H01L21/26
- H01L21/31—Treatment of semiconductor bodies using processes or apparatus not provided for in groups H01L21/20 - H01L21/26 to form insulating layers thereon, e.g. for masking or by using photolithographic techniques; After treatment of these layers; Selection of materials for these layers
- H01L21/3205—Deposition of non-insulating-, e.g. conductive- or resistive-, layers on insulating layers; After-treatment of these layers
- H01L21/32051—Deposition of metallic or metal-silicide layers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L21/00—Processes or apparatus adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof
- H01L21/02—Manufacture or treatment of semiconductor devices or of parts thereof
- H01L21/04—Manufacture or treatment of semiconductor devices or of parts thereof the devices having at least one potential-jump barrier or surface barrier, e.g. PN junction, depletion layer or carrier concentration layer
- H01L21/50—Assembly of semiconductor devices using processes or apparatus not provided for in a single one of the subgroups H01L21/06 - H01L21/326, e.g. sealing of a cap to a base of a container
- H01L21/56—Encapsulations, e.g. encapsulation layers, coatings
- H01L21/561—Batch processing
Abstract
The invention belongs to field of medical article technology, more particularly to a kind of intelligent adhesive bandage, including adhesive bandage body, the power module being electrically connected with adhesive bandage body provided with intellectual monitoring module and with intellectual monitoring module, intellectual monitoring module includes blood examination chip, data acquisition module and the wireless communication module for transmitting gathered data to intelligent terminal；Blood examination chip includes carrier substrate, the conductive substrate located at carrier substrate and is covered in the insulation glue-line of conductive substrate, insulation glue-line offers probe through hole, probe through hole is provided with the nano metal probe for protruding from insulation film surface, nano metal probe includes metal probe body and is distributed in the thorn-like projection of metal probe body surface, and thorn-like is raised and its surrounding is attached with the antibody molecule for detecting pathogen.The present invention can also effectively monitor the health data of user, allow user to know the health status of itself in time, eliminate the trouble that hospital takes a blood sample in addition to the function of possessing wound healing.
Description
Technical field
The invention belongs to medical and hygiene article technical field, more particularly to a kind of intelligent adhesive bandage.
Background technology
In daily life, people usually abrade because of not noting or scratch oneself, cause skin exterior trauma, for
Minor trauma, people often pay no attention to, and do not go processing, allow their own slowly to heal, in this process, often cause wound
Face is infected, the problems such as wound healing is difficult.Adhesive bandage is a kind of portable preferable dressings, for stopping for acute minor cut or wound
Blood, anti-inflammatory and Wound healing, the especially wrapping of the wound such as injury in the wild.At present, common adhesive bandage on the market, generally divides
The adhesive bandage of adhesive bandage and common plastic film for fabric texture, the adhesive bandage of fabric texture is non-watertight and poorly sealed, special
Turning joint position is not used in, such as finger-joint becomes easily infected by water, so easily makes wound infection, so as to cause wound
Mouth deteriorates, and because wound is wrapped, it is impossible to wound infection, the pain of making patients are found in time；The wound of common plasticses film
It can paste due to not moisture-penetrable ventilated, use time length easily causes wound face infection, makes wound be difficult to heal.Although above-mentioned two classes wound
Can paste respectively has quality, but is respectively provided with anti-inflammation, promotes effect of wound healing.However, in nowadays this intellectualization times, it is existing
Some adhesive bandages seem that function is single, for example, can not learn the physical condition of user, therefore, are badly in need of a kind of function of research and development
Comprehensive adhesive bandage.
It is well known that blood is flowed in heart and endovascular opaque red liquid, main component is blood plasma, blood is thin
Three kinds of born of the same parents and blood platelet.Haemocyte is divided into red blood cell and leucocyte again.In blood contain various nutritional ingredients, such as inorganic salts, oxygen,
Metabolite, hormone, enzyme and antibody etc., nutritious tissue, regulation organ activity and the effect for defending harmful substance.Each device of human body
The physiology of official and pathological change, often cause the change of blood constituent, therefore are often required to diagnose the illness by blood examination after illness.
That is, adhesive bandage can be used to complete the process of blood examination completely, therefore, a both pacified it is necessory to research and develop
Complete comfortable, easy to use, the intelligent adhesive bandage that the health status of user can be detected again.
The content of the invention
It is an object of the invention to：It is single for existing adhesive bandage function, the low deficiency of intelligence degree, and provide a kind of
Both safety and comfort, easy to use, the intelligent adhesive bandage that the health status of user can be detected again.
To achieve the above object, the present invention is adopted the following technical scheme that：
Intellectual monitoring module and and intelligence are provided with a kind of intelligent adhesive bandage, including adhesive bandage body, the adhesive bandage body
The power module that energy monitoring modular is electrically connected with, the intellectual monitoring module includes that blood examination chip and the institute of blood can be detected
The wireless communication module stated the data acquisition module of blood examination chip electric connection and transmit gathered data to intelligent terminal；
The blood examination chip includes carrier substrate, is arranged at the conductive substrate of the carrier substrate and is covered in the conductive substrate
Insulation glue-line, the insulation glue-line offers probe through hole, and the probe through hole, which is provided with, protrudes from insulation film surface
Nano metal probe, the nano metal probe includes metal probe body and is distributed in the thorn-like of metal probe body surface
Projection, the thorn-like is raised and its surrounding is attached with the antibody molecule for detecting pathogen, and the antibody molecule is DNA molecular, RNA
At least one of molecule and immobilised enzymes molecule.
Wherein, the blood examination chip can carry out real-time blood test, can be given within several minutes even several seconds
Go out blood test results.So as to allow user to know the health status of oneself in time, to carry out timely prevention from suffering from the diseases
Or treatment, while eliminating the trouble that hospital is taken a blood sample, this highly shortened the interval between detection and treatment
Time so that user can quickly, obtain diagnostic data at low cost, and the blood examination conventional compared to hospital, the blood examination
Chip causes detection more convenient, more efficient.
The Cleaning Principle of blood examination chip is in the present invention：Attract and capture to deposit in blood sample by antibody molecule
Pathogen molecule, and nano metal probe is then equivalent to microsensor, when the antibody molecule and cause of disease that are attached to its surface
When body molecule is combined, nano metal probe can produce electric current, and pathogen molecule is determined according to the power of the electric current of generation
Type.
Because all DNA fragmentations have excellent characteristics, optionally can closely it be tied with another segment DNA fragment
Close.For example, the antibody molecule by designing and synthesizing high degree of specificity, the antibody molecule is attached on nano metal probe,
The DNA molecular of staphylococcus aureus present in blood is caught with this, when the antibody molecule and the DNA of staphylococcus aureus
When molecule is combined, nano metal probe will produce electric current.
In addition, immobilised enzymes molecule can also be adhered in the present invention to detect the component target in blood, such as in nanometer
Adhere to the glucose oxidase of solidification on metal probe, for measuring the concentration of glucose in blood；On nano metal probe
Adhere to the LO of solidification, for measuring the concentration of lactic acid in blood；The courage for adhering to solidification on nano metal probe is consolidated
Alcohol oxidase and cholesterol ester hydrolase, for measuring the concentration of Blood Cholesterol；Adhere to solidification on nano metal probe
B- HBDs and reducibility coenzyme, for measuring the concentration of ketoboidies in blood.Its principle is that these immobilised enzymes divide
With the material such as the blood glucose in blood, cholesterol, lactic acid, ketoboidies redox reaction occurs for son respectively, produces oxidation current, therefore
The concentration of the materials such as Blood Glucose, cholesterol, lactic acid and ketoboidies can be determined by the size for measuring electric current.
It should be noted that the present invention can set multiple nano metal probe structures on the surface of carrier substrate, every
Different types of antibody molecule is adsorbed on individual nano metal probe.So, as soon as only needing bleed sample, energy on blood examination chip
Multiple pathogens are analyzed, and most methods are once only capable of detecting a kind of pathogen molecule.
Inventor has found that one drips the quantity levels of pathogen molecule and doctor's syringe needle in blood sample in research process
The blood sample of taking-up is suitable.In this case, the pathogen molecule of a drop blood sample is typically less than 1000, even
Less.Even if having adjusted the quantity of pathogen molecule, its quantity in blood sample is set to reach million ranks, the electricity detected
Flow signal also fainter.Pass through the peptizaiton that thorn-like is raised so that have bigger space around antibody molecule, carry disease
The liquid of substance molecule flows through these spaces and is also easier to, so, and antibody molecule and pathogen molecule also just have much more machine
It can be in contact with each other, so as to effectively improve sensitivity and the accuracy of detection.
Improved as a kind of of intelligent adhesive bandage of the invention, the thorn-like is raised and its surrounding is also attached with metallic molecule
Ruthenium.Wherein, metallic molecule ruthenium because ruthenium carries the positive charge of a unit, therefore can be adsorbed equivalent to the effect of amplifier
On pathogen molecule with a negative electrical charge；So, the complex of ruthenium and pathogen molecule is easy to from nano metal probe
On seize electronics, so as to produce one electric current for being enough to detect.
Improved as a kind of of intelligent adhesive bandage of the invention, the metal probe body includes being arranged in probe through hole
Metal cartridge, and the hemispherical metallic substrates of insulation film surface are protruded from, the thorn-like projection is distributed in the hemispherical
The surface of metallic substrates.Compared to square structure, the surface of metal probe body is designed to hemispherical dome structure, can so be had
The surface area of effect increase metal probe, so as to be more beneficial for follow-up thorn-like raised " growth ", and antibody molecule attachment with
It is scattered.
Improved as a kind of of intelligent adhesive bandage of the invention, the raised height of the thorn-like is 1 ~ 100nm.If thorn-like is raised
Height it is too small, then can not play a part of effectively disperseing antibody molecule；If the raised height of thorn-like is excessive, disperse antibody molecule
Effect does not increase anti-drop, so can not only increase manufacturing cost, while can increase the volume of whole blood examination chip yet.
Improved as a kind of of intelligent adhesive bandage of the invention, the preparation method of the blood examination chip comprises the following steps：
Step 1: carrying out surface cleaning processing to carrier substrate, conductive substrate and photoresist layer are then coated successively, then in purple
It is exposed and develops under the irradiation of outer light, and unexposed conductive substrate is removed using metal etchants, with needed for is formed
Circuitous pattern；
Step 2: stripping photolithography glue-line, and washing and drying treatment is carried out, the glue-line that insulate is then coated with, and insulation glue-line is entered
Row gets through hole processing, obtains the chip substrate of the through hole containing probe；
Step 3: chip substrate is put into the electroplating bath containing metal salt solution, switch on power, electricity is carried out to probe through hole
Plating, the voltage for control plating is 5 μ V ~ 500mV, and the electric current of plating is 0.01 μ A ~ 100mA, plating duration for 1 ~
30min；
Step 4: after the completion of to be electroplated, 1 ~ 10h of vacuum drying is carried out at a temperature of 25 ~ 85 DEG C, obtaining surface distributed has thorn-like
Raised nano metal probe；
Step 5: thorn-like it is raised and its around load detecting pathogen antibody molecule, be then packaged processing, that is, obtain
Described blood examination chip.
Wherein, carrier substrate is silicon chip, graphene substrate or silicon carbide substrate, and it is excellent chip carrier, is
High-precision blood examination chip provides important foundation；Insulation glue-line then plays insulation passivation, in order to nano metal probe
Make；The conduction and detection connection of conductive substrate then for electric current.
It should be noted that in blood examination chip fabrication processes, the time of plating is crucial, if the overlong time of plating,
The raised metal probe structure of thorn-like containing nanometer can not just be obtained；But the time of plating is too short, and metal probe structure just arrives nanometer
Level just stops " growth ", can not equally obtain required nano metal probe.In addition, the control to electroplating voltage/electric current is also
Of crucial importance, otherwise, electroplating voltage/electric current is too high or too low can not also to obtain required nano metal probe.
Improved as a kind of of intelligent adhesive bandage of the invention, metal salt solution is by HAuCl described in step 34Pressed with HCl
Volume ratio 1：（1~10）Mix, wherein HAuCl4Concentration be 5 ~ 100mmol/L, HCl concentration is 10 ~ 500mmol/L.
Gold is the good conductor of electric current, therefore, and selection Nano-Au probe can effectively improve sensitivity and the accuracy of detection.
Improved as a kind of of intelligent adhesive bandage of the invention, the adhesive bandage body includes sticky backing and is bonded in described
The wound protective bandage pad of sticky backing, the wound protective bandage pad is located at the middle part of sticky backing, and the two ends of the sticky backing are respectively equipped with release
Paper, one end of the release liners and the end of the sticky backing are bonded, and the other end of the release liners is covered in the shield wound
The surface of pad.Wherein, the use material of sticky backing, wound protective bandage pad and release liners, and the specific preparation method of adhesive bandage body can join
Chinese patent CN104208744 is examined, is repeated no more here.
Improved as a kind of of intelligent adhesive bandage of the invention, the sticky backing uses PU films, PE or PEVA, is coated with low mistake
Quick medical pressure sensitive adhesive is made；It can make adhesive bandage that there is good waterproof effect using the sticky backing.
Improved as a kind of of intelligent adhesive bandage of the invention, the sticky backing uses stretch fabric, is coated with low allergy medical
Pressure sensitive adhesive is made；It can make adhesive bandage that there is good elasticity using the sticky backing.
Improved as a kind of of intelligent adhesive bandage of the invention, the sticky backing is coated with low using non-woven fabrics or punching PE
Allergy medical pressure sensitive adhesive is made；It can make adhesive bandage that there is good air permeable effect using the sticky backing.
Improved as a kind of of intelligent adhesive bandage of the invention, the wound protective bandage pad coats PVP-I system using adhesive-bonded fabric
；Preferably, in the adhesive-bonded fabric content of PVP-I in 0.005~1.5g/m2 Between.
Improved as a kind of of intelligent adhesive bandage of the invention, the intellectual monitoring module is arranged on wound protective bandage pad and sticky backing
Between.So the blood clot that the blood initially flowed out may contain is filtered out by wound protective bandage pad, it is pure equivalent to having been carried out to blood
Change, prevent from influenceing the testing result of blood examination chip.
Improved as a kind of of intelligent adhesive bandage of the invention, the intelligent terminal is connected with cloud server, the intelligence
Terminal is at least one of mobile phone, computer and wearable device.By the present invention in that intelligent terminal is connected with cloud server,
To can so gather every time and analysis data Cun Chudao cloud servers, be disease in the future so as to set up individual database
Diagnosis provides important references.
A kind of as adhesive bandage of the invention intelligent improves, the wireless communication module be bluetooth, RFID, Z-wave,
At least one of HomeRF, ZigBee, UWB, NFC, IrDA and Wi-Fi.
Improved as a kind of of intelligent adhesive bandage of the invention, the intellectual monitoring module also includes sensor, the sensing
Device is electrically connected with the data acquisition module, and the sensor is temperature sensor, humidity sensor, flow sensor, pressure
At least one of force snesor and heat-sensitive sensor.Its main function is to the internal environment of adhesive bandage and to blood physiology number
According to analysis and detection；For example, the internal environment of adhesive bandage can be monitored by temperature and moisture sensors, and pass through intelligent end
User is reminded to change adhesive bandage in the suitable time in end；Moreover, it is also possible to by setting the sensor of difference in functionality to recognize blood
The physiological datas such as the color of liquid, pH value, and bacterial concentration, and the data of collection are sent to intelligent end by wireless communication module
End, the physiological status of user is relatively can be inferred that by carrying out data analysis, will be carried during exception if it find that physiology has
Awake user goes examination in hospital to treat in time, full-scope safeguards user health.
The beneficial effects of the present invention are：The present invention not only has the function of general adhesive bandage but also merges advanced electronics
Science and technology, blood testing knot can be provided by the intrinsic blood examination chip of adhesive bandage within several minutes even several seconds
Really, and testing result can be sent to intelligent terminal by radio communication in time, obtains the interpretation of result of specialty, used so as to allow
Person can know the health status of oneself in time, to carry out timely prevention from suffering from the diseases or treatment；Eliminate simultaneously and usually arrive doctor
The trouble that institute is taken a blood sample, this highly shortened the interval time between detection and treatment so that user can be fast
Speed, obtain diagnostic data at low cost, and the blood examination conventional compared to hospital, the blood examination chip make it that detection is more convenient, more
Efficiently, its physiological status that user is relatively can be inferred that by carrying out data analysis, if it find that physiology is incited somebody to action when having exception
User can be reminded to go examination in hospital to treat in time, full-scope safeguards user health lifts quality of life.
Brief description of the drawings
Fig. 1 is structural representation of the invention.
Fig. 2 is longitudinal sectional view of the invention.
Fig. 3 is workflow diagram of the invention.
Fig. 4 is the structural representation of blood examination chip in the present invention.
Fig. 5 is the longitudinal sectional view of blood examination chip in the present invention.
Fig. 6 is the structural representation in the present invention during blood examination detecting pathogen.
In figure：
1- adhesive bandage bodies；
11- viscosity backings；12- wound protective bandage pads；13- release liners；
2- intellectual monitoring modules；
21- blood examination chips；211- carrier substrates；212- conductive substrates；213- insulation glue-lines；214- probe through holes；215- nanometers
Metal probe；2151- metal probe bodies；21511- metal cartridges；21512- metallic substrates；2152- thorn-likes are raised；2153-
Antibody molecule；216- pathogen molecules；
22- sensors；23- data acquisition modules；24- wireless communication modules；
3- power modules；
4- intelligent terminals；
5- cloud servers.
Embodiment
With reference to the accompanying drawings and detailed description, the present invention and its advantageous effects are described in detail, still,
The embodiment of the present invention is not limited to this.
As shown in Fig. 1 ~ 6, a kind of intelligent adhesive bandage, including adhesive bandage body 1 is provided with intelligent prison in adhesive bandage body 1
Survey module 2 and the power module 3 being electrically connected with intellectual monitoring module 2.
Adhesive bandage body 1 includes sticky backing 11 and is bonded in the wound protective bandage pad 12 of sticky backing 11, and wound protective bandage pad 12 is located at viscous
Property backing 11 middle part, the two ends of sticky backing 11 are respectively equipped with release liners 13, one end of release liners 13 and sticky backing 11
End is bonded, and the other end of release liners 13 is covered in the surface of wound protective bandage pad 12.Wherein, sticky backing 11 can use PU films, PE
Or PEVA, it is coated with low allergy medical pressure sensitive adhesive and is made, so can makes adhesive bandage that there is good waterproof effect；Sticky backing 11
Stretch fabric can be used, low allergy medical pressure sensitive adhesive is coated with and is made, so can make adhesive bandage that there is good elasticity；Sticky backing
11 can also be coated with low allergy medical pressure sensitive adhesive and are made, adhesive bandage can so had well using non-woven fabrics or punching PE
Air permeable effect；And wound protective bandage pad 12 coats Yunnan Baiyao using adhesive-bonded fabric or coating PVP-I is made, it is preferable that Yunnan Baiyao
Or in adhesive-bonded fabric PVP-I content in 0.005~1.5g/m2 Between.
Intellectual monitoring module 2 includes the data that can be detected the blood examination chip 21 of blood, be electrically connected with blood examination chip 21
Acquisition module 23 and the wireless communication module 24 for transmitting gathered data to intelligent terminal 4, make intelligent terminal 4 be taken with high in the clouds
Business device 5 is connected, the data Cun Chudao cloud servers 5 that so will can every time gather and analyze, so that individual database is set up,
Important references are provided for medical diagnosis on disease in the future.Wherein, intelligent terminal 4 is at least one of mobile phone, computer and wearable device；
Wireless communication module 24 is at least one in bluetooth, RFID, Z-wave, HomeRF, ZigBee, UWB, NFC, IrDA and Wi-Fi
Kind.
It is preferred that, intellectual monitoring module 2 of the invention is arranged between wound protective bandage pad 12 and sticky backing 11；So pass through shield
Wound pad 12 filters out the blood clot that the blood initially flowed out may contain, and is purified equivalent to blood, prevents from influenceing blood
Examine the testing result of chip 21.
Wherein, blood examination chip 21 includes carrier substrate 211, is arranged at the conductive substrate 212 of carrier substrate 211 and covers
The insulation glue-line 213 of conductive substrate 212 is placed on, insulation glue-line 213 offers probe through hole 214, and probe through hole 214 is provided with prominent
For the nano metal probe 215 on insulation glue-line 213 surface, nano metal probe 215 include metal probe body 2151 and
The thorn-like projection 2152 on the surface of metal probe body 2151 is distributed in, thorn-like projection 2152 and its surrounding are attached with detection pathogen
Antibody molecule 2153, antibody molecule 2153 is at least one of DNA molecular, RNA molecule and immobilised enzymes molecule.
The blood examination chip 21 of the present invention can carry out real-time blood test, can be given within several minutes even several seconds
Go out blood test results；So as to allow user to know the health status of oneself in time, to carry out timely prevention from suffering from the diseases
Or treatment, while eliminating the trouble that hospital is taken a blood sample, this highly shortened the interval between detection and treatment
Time so that user can quickly, obtain diagnostic data at low cost, and the blood examination conventional compared to hospital, the blood examination
Chip 21 causes detection more convenient, more efficient.
The Cleaning Principle of blood examination chip 21 is in the present invention：Being attracted by antibody molecule 2153 and captured may be in blood sample
Pathogen molecule 216 present in this, and nano metal probe 215 is then equivalent to microsensor, when being attached to the anti-of its surface
Body molecule 2153 is when pathogen molecule 216 is combined, and nano metal probe 215 can produce electric current, according to the electric current of generation
Power determines the type of pathogen molecule 216.
Because all DNA fragmentations have excellent characteristics, optionally can closely it be tied with another segment DNA fragment
Close.For example, the antibody molecule 2153 by designing and synthesizing high degree of specificity, nano metal is attached to by the antibody molecule 2153
On probe 215, the DNA molecular of staphylococcus aureus present in blood is caught with this, when the antibody molecule 2153 with it is golden yellow
When the staphylococcic DNA molecular of color is combined, nano metal probe 215 will produce electric current.
In addition, immobilised enzymes molecule can also be adhered in the present invention to detect the component target in blood, such as in nanometer
Adhere to the glucose oxidase of solidification on metal probe 215, for measuring the concentration of glucose in blood；In nano metal probe
Adhere to the LO of solidification on 215, for measuring the concentration of lactic acid in blood；Adhere on nano metal probe 215 solid
The cholesterol oxidase and cholesterol ester hydrolase of change, for measuring the concentration of Blood Cholesterol；In nano metal probe 215
The b- HBDs and reducibility coenzyme of upper attachment solidification, for measuring the concentration of ketoboidies in blood.Its principle is, these
With the material such as the blood glucose in blood, cholesterol, lactic acid, ketoboidies redox reaction occurs for immobilised enzymes molecule respectively, produces oxygen
Galvanic current, therefore the dense of the materials such as Blood Glucose, cholesterol, lactic acid and ketoboidies can be determined by the size for measuring electric current
Degree.
It should be noted that the present invention can set multiple knots of nano metal probe 215 on the surface of carrier substrate 211
Structure, adsorbs different types of antibody molecule 2153 on each nano metal probe 215.So, on blood examination chip 21
As soon as only needing sample of bleeding, multiple pathogens can be analyzed, and most methods are once only capable of detecting a kind of pathogen molecule 216.
Inventor has found that the quantity levels of pathogen molecule 216 are used with doctor in a drop blood sample in research process
The blood sample that syringe needle takes out is suitable.In this case, the pathogen molecule 216 of a drop blood sample is typically less than 1000
It is individual, or even less.Even if having adjusted the quantity of pathogen molecule 216, its quantity in blood sample is set to reach million ranks,
The current signal detected is also fainter.Pass through the peptizaiton of thorn-like projection 2152 so that have around antibody molecule 2153
Bigger space, the liquid that carry pathogen molecule 216 flows through these spaces and is also easier to, so, the He of antibody molecule 2153
Pathogen molecule 216 also just has much more chance to be in contact with each other, so as to effectively improve sensitivity and the accuracy of detection.
As the preferred scheme of the present invention, thorn-like is raised and its surrounding is also attached with metallic molecule ruthenium.Wherein, metallic molecule
Ruthenium because positive charge of the ruthenium with unit, therefore can be adsorbed with negative electrical charge equivalent to the effect of amplifier
On pathogen molecule 216；So, the complex of ruthenium and pathogen molecule 216 is easy to seize electricity from nano metal probe 215
Son, so as to produce one electric current for being enough to detect.
As the preferred scheme of the present invention, metal probe body 2151 includes the metal column being arranged in probe through hole 214
Body 21511, and the hemispherical metallic substrates 21512 on insulation glue-line 213 surface are protruded from, thorn-like projection 2152 is distributed in hemisphere
The surface of shape metallic substrates 21512.Compared to square structure, the surface of metal probe body 2151 is designed to hemispherical junction
Structure, can so be effectively increased the surface area of metal probe, so that " growth " of follow-up thorn-like projection 2152 is more beneficial for, and
The attachment of antibody molecule 2153 and scattered.
As the preferred scheme of the present invention, the height of thorn-like projection 2152 is 1 ~ 100nm.If the height of thorn-like projection 2152
It is too small, then it can not play a part of effectively disperseing antibody molecule 2153；If the height of thorn-like projection 2152 is excessive, disperse antibody point
Sub 2153 effects do not increase anti-drop, so can not only increase manufacturing cost, while can increase the volume of whole blood examination chip 21 yet.
As the preferred scheme of the present invention, the preparation method of blood examination chip 21 comprises the following steps：
Step 1: carrying out surface cleaning processing to carrier substrate 211, conductive substrate 212 and photoresist layer are then coated successively, is connect
And be exposed and develop under the irradiation of ultraviolet light, and unexposed conductive substrate 212 is removed using metal etchants, with shape
Into required circuitous pattern；Wherein, conductive substrate 212 is conductive metal layer, preferably layer gold or layers of copper, and photoresist layer is preferred
SU-8 photoresists；
Step 2: stripping photolithography glue-line, and washing and drying treatment is carried out, the glue-line 213 that insulate is then coated with, and to insulation glue-line
213 carry out getting through hole processing, obtain the chip substrate of through hole containing probe 214；Wherein, insulation glue-line 213 is novolac resin layer, ring
Oxygen tree lipid layer, polyimide resin layer, polyester resin layer, polyphenylene oxide resin layer, cyanate resin lipid layer or polyflon
Layer；
Step 3: chip substrate is put into the electroplating bath containing metal salt solution, switch on power, probe through hole 214 is carried out
Plating, the voltage for control plating is 5 μ V ~ 500mV, and the electric current of plating is 0.01 μ A ~ 100mA, plating duration for 1 ~
30min；
Step 4: after the completion of to be electroplated, 1 ~ 10h of vacuum drying is carried out at a temperature of 25 ~ 85 DEG C, obtaining surface distributed has thorn-like
The nano metal probe 215 of projection 2152；
Step 5: thorn-like projection 2152 and its around load detecting pathogen antibody molecule 2153, be then packaged place
Reason, that is, the blood examination chip 21 obtained.
Wherein, carrier substrate 211 is silicon chip, graphene substrate or silicon carbide substrate, and it is excellent chip carrier,
Important foundation is provided for high-precision blood examination chip 21；Insulation glue-line 213 then plays insulation passivation, in order to nano metal
The making of probe 215；The conduction and detection connection of conductive substrate 212 then for electric current.
It should be noted that in the manufacturing process of blood examination chip 21, the time of plating is crucial, if the time mistake of plating
It is long, it can not just obtain the metal probe structure of the projection of thorn-like containing nanometer 2152；But the time of plating is too short, and metal probe structure is firm
Just stop " growing " to nanoscale, can not equally obtain required nano metal probe 215.In addition, to electroplating voltage/electric current
Control is also of crucial importance, and otherwise, electroplating voltage/electric current is too high or too low can not also to obtain required nano metal probe 215.
As the preferred scheme of the present invention, metal salt solution is by HAuCl in step 34With HCl by volume 1：（1~10）
Mix, wherein HAuCl4Concentration be 5 ~ 100mmol/L, HCl concentration is 10 ~ 500mmol/L.Gold is the good of electric current
Conductor, therefore, selection Nano-Au probe can effectively improve sensitivity and the accuracy of detection.
As the preferred scheme of the present invention, intellectual monitoring module 2 also includes sensor 22, sensor 22 and data acquisition module
Block 23 is electrically connected with, and sensor 22 is temperature sensor, humidity sensor, flow sensor, pressure sensor and heat-sensitive sensor
At least one of device.Its main function is the internal environment to adhesive bandage and the analysis and detection to blood physiology data；Example
Such as, the internal environment of adhesive bandage can be monitored by temperature and moisture sensors, and reminds user closing by intelligent terminal 4
The suitable time changes adhesive bandage；Moreover, it is also possible to the color of the identification blood of sensor 22 by setting difference in functionality, pH value,
And the physiological data such as bacterial concentration, and the data of collection are sent to intelligent terminal 4 by wireless communication module 24, pass through and carry out
Data analysis relatively can be inferred that the physiological status of user, user will be reminded timely during exception if it find that physiology has
Examination in hospital is gone to treat, full-scope safeguards user health.
The announcement and teaching of book according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and changed.Therefore, the invention is not limited in above-mentioned embodiment, every those skilled in the art exist
Made any conspicuously improved, replacement or modification belong to protection scope of the present invention on the basis of the present invention.This
Outside, although having used some specific terms in this specification, these terms merely for convenience of description, not to the present invention
Constitute any limitation.
Claims (10)
1. it is provided with intellectual monitoring module, Yi Jiyu in a kind of intelligent adhesive bandage, including adhesive bandage body, the adhesive bandage body
Intellectual monitoring module be electrically connected with power module, the intellectual monitoring module include can detect blood blood examination chip, with
The data acquisition module of the blood examination chip electric connection and the radio communication mold for transmitting gathered data to intelligent terminal
Block；The blood examination chip includes carrier substrate, is arranged at the conductive substrate of the carrier substrate and is covered in the conductive base
The insulation glue-line of layer, the insulation glue-line offers probe through hole, and the probe through hole, which is provided with, protrudes from insulation film surface
Nano metal probe, the nano metal probe includes metal probe body and is distributed in the thorn of metal probe body surface
Shape is raised, and the thorn-like is raised and its surrounding is attached with the antibody molecule for detecting pathogen.
2. intelligent adhesive bandage according to claim 1, it is characterised in that：The antibody molecule is DNA molecular, RNA molecule
At least one of with immobilised enzymes molecule.
3. intelligent adhesive bandage according to claim 1, it is characterised in that：The thorn-like is raised and its surrounding is also attached with gold
Belong to molecule ruthenium.
4. intelligent adhesive bandage according to claim 1, it is characterised in that：The metal probe body includes being arranged at probe
Metal cartridge in through hole, and the hemispherical metallic substrates of insulation film surface are protruded from, the thorn-like projection is distributed in institute
State the surface of hemispherical metallic substrates.
5. intelligent adhesive bandage according to claim 1, it is characterised in that：The raised height of the thorn-like is 1 ~ 100nm.
6. intelligent adhesive bandage according to claim 1, it is characterised in that the preparation method of the blood examination chip includes following
Step：
Step 1: carrying out surface cleaning processing to carrier substrate, conductive substrate and photoresist layer are then coated successively, then in purple
It is exposed and develops under the irradiation of outer light, and unexposed conductive substrate is removed using metal etchants, with needed for is formed
Circuitous pattern；
Step 2: stripping photolithography glue-line, and washing and drying treatment is carried out, the glue-line that insulate is then coated with, and insulation glue-line is entered
Row gets through hole processing, obtains the chip substrate of the through hole containing probe；
Step 3: chip substrate is put into the electroplating bath containing metal salt solution, switch on power, electricity is carried out to probe through hole
Plating, the voltage for control plating is 5 μ V ~ 500mV, and the electric current of plating is 0.01 μ A ~ 100mA, plating duration for 1 ~
30min；
Step 4: after the completion of to be electroplated, 1 ~ 10h of vacuum drying is carried out at a temperature of 25 ~ 85 DEG C, obtaining surface distributed has thorn-like
Raised nano metal probe；
Step 5: thorn-like it is raised and its around load detecting pathogen antibody molecule, be then packaged processing, that is, obtain
Described blood examination chip.
7. intelligent adhesive bandage according to claim 6, it is characterised in that：Metal salt solution is by HAuCl described in step 34
With HCl by volume 1：（1~10）Mix, wherein HAuCl4Concentration be 5 ~ 100mmol/L, HCl concentration for 10 ~
500mmol/L。
8. intelligent adhesive bandage according to claim 1, it is characterised in that：The adhesive bandage body includes
Sticky backing and the wound protective bandage pad for being bonded in the sticky backing.
9. intelligent adhesive bandage according to claim 1, it is characterised in that：The intelligent terminal is connected with cloud server,
The intelligent terminal is at least one of mobile phone, computer and wearable device；The wireless communication module be bluetooth, RFID,
At least one of Z-wave, HomeRF, ZigBee, UWB, NFC, IrDA and Wi-Fi.
10. intelligent adhesive bandage according to claim 1, it is characterised in that：The intellectual monitoring module also includes sensor,
The sensor is electrically connected with the data acquisition module, and the sensor is temperature sensor, humidity sensor, flow biography
At least one of sensor, pressure sensor and heat-sensitive sensor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710336787.2A CN107049604A (en) | 2017-05-14 | 2017-05-14 | Intelligent adhesive bandage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710336787.2A CN107049604A (en) | 2017-05-14 | 2017-05-14 | Intelligent adhesive bandage |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107049604A true CN107049604A (en) | 2017-08-18 |
Family
ID=59597454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710336787.2A Pending CN107049604A (en) | 2017-05-14 | 2017-05-14 | Intelligent adhesive bandage |
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| Country | Link |
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| CN (1) | CN107049604A (en) |
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| CN108403297A (en) * | 2018-03-12 | 2018-08-17 | 南京理工大学 | A kind of intelligence dressing and preparation method thereof |
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| CN111166562A (en) * | 2020-01-07 | 2020-05-19 | 佛山市优特医疗科技有限公司 | Intelligent wound dressing |
| CN112469375A (en) * | 2018-06-15 | 2021-03-09 | 科洛普拉斯特公司 | Accessory device for wound dressing system and related method for communicating operating status |
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Application publication date: 20170818 |