CN106918573A - Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate - Google Patents
Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate Download PDFInfo
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- CN106918573A CN106918573A CN201710283937.8A CN201710283937A CN106918573A CN 106918573 A CN106918573 A CN 106918573A CN 201710283937 A CN201710283937 A CN 201710283937A CN 106918573 A CN106918573 A CN 106918573A
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- dialyzate
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- near infrared
- creatinine content
- blood
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- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 title claims abstract description 196
- 229940109239 creatinine Drugs 0.000 title claims abstract description 98
- 238000012544 monitoring process Methods 0.000 title claims abstract description 89
- 238000001631 haemodialysis Methods 0.000 title claims abstract description 78
- 230000000322 hemodialysis Effects 0.000 title claims abstract description 78
- 238000000034 method Methods 0.000 title claims abstract description 17
- 210000004369 blood Anatomy 0.000 claims description 61
- 239000008280 blood Substances 0.000 claims description 61
- 238000002329 infrared spectrum Methods 0.000 claims description 36
- 239000000523 sample Substances 0.000 claims description 36
- 230000004087 circulation Effects 0.000 claims description 24
- 238000001228 spectrum Methods 0.000 claims description 23
- 238000000502 dialysis Methods 0.000 claims description 20
- 238000001514 detection method Methods 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 15
- 230000017531 blood circulation Effects 0.000 claims description 12
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 11
- 229960002897 heparin Drugs 0.000 claims description 11
- 229920000669 heparin Polymers 0.000 claims description 11
- 210000003462 vein Anatomy 0.000 claims description 11
- 238000004064 recycling Methods 0.000 claims description 10
- 210000001367 artery Anatomy 0.000 claims description 9
- 239000000385 dialysis solution Substances 0.000 claims description 9
- 230000003595 spectral effect Effects 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 230000005540 biological transmission Effects 0.000 claims description 3
- 239000003182 parenteral nutrition solution Substances 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 2
- 238000012360 testing method Methods 0.000 abstract description 3
- 208000017169 kidney disease Diseases 0.000 abstract description 2
- 238000009738 saturating Methods 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 3
- 230000036772 blood pressure Effects 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000024924 glomerular filtration Effects 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000004497 NIR spectroscopy Methods 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 208000028208 end stage renal disease Diseases 0.000 description 1
- 201000000523 end stage renal failure Diseases 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000009246 food effect Effects 0.000 description 1
- 235000021471 food effect Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000013332 literature search Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000009659 non-destructive testing Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000000192 social effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
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- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
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Abstract
The present invention relates to creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate, dialysate samples testing model is set up using near infrared spectrometer and the changes of contents of creatinine in hemodialysis dialyzate is monitored on-line, changes of contents rule according to creatinine in hemodialysis dialyzate is monitored, prevented, avoiding hemodialysis accident from occurring, so as to provide scientific basis for the treatment of uremic patient, the purpose for improving patient's treatment of kidney disease level is reached.
Description
Technical field
The present invention relates to creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate, more particularly to one kind is adopted
With creatinine content on-line monitoring method and system in the hemodialysis dialyzate of near infrared spectrum detection.
Background technology
At present, blood purification in clinical treatment by widespread need.By taking kidney trouble dialysis treatment as an example, China there are about 200
Ten thousand End-stage Renal Disease Patients, 400,000 are receiving hemodialysis, and every year with the speed increase more than 10%, patient is controlled dialysis
The demand for the treatment of is very big.
Blood dialysis therapy is, using the principle of pellicle, the blood of patient and dialyzate to be introduced inside and outside dialyzer simultaneously
Side, solute gradient, osmotic gradient and the spread by means of film both sides by diffusion, convection current, remove toxin etc., by this
Method removes the excessive moisture and metabolic waste of internal retention, while leaving required material, corrects electrolyte and soda acid is flat
Weighing apparatus is disorderly.
Creatinine (CR) is the product of human muscle's metabolism, mainly by creatine by the irreversible slow shape of non-enzymatic dehydration
Into, then be discharged into blood, with homaluria, it is difficult by food effect, can be by glomerular filtration, seldom can quilt in renal tubule
Absorb again, creatinine includes serum creatinine and UCr, serum creatinine measurement renal function is more meaningful, and it is to comment that serum creatinine concentration is determined
The efficiency index of valency glomerular filtration rate(GFR, can effectively reflect the substantial damage degree of renal function, and clinically detection contributes to
Judge the state of an illness, it is significant.
When carrying out hemodialysis to the exceeded patient of creatinine content in blood, dialyzer need to be used.Dialyzer may go out
Now block or disrepair phenomenon.The reason for dialyzer is blocked mainly has：A, blood are oversize from the pump time in vitro, and this is that dialyzer is blocked
Main cause；B, heparin consumption are not enough, patient dialyse first heparin injection rate it is particularly significant, usually 0.2~0.5mg/
Kg, if test tube of hepari is insufficient first, adds heparin amount big also without positive effect again in dialysis；C, dialysis person itself because disease,
In ephrosis latter stage at end, blood viscosity increases.
Dialyzer be blocked after should change in time, otherwise extracorporal circulatory system stop, arterial blood line, vein bloody path also can therewith by
It is stifled, cause dialysis person's blood largely to lose, it is very harmful.And observe general 5~10 minutes of the process that dialyzer is blocked, in order to and
Shi Faxian dialyzer cloggings, it is necessary to monitored on-line to dialysis procedure, search out the Changing Pattern of dialysate concentration.
Such as when dialysis membrane is progressively blocked, creatinine content in dialyzate can gradually step-down, when with normal creatinine content more than a fixed limit
When spending, can in time be reminded by warning device, be prevented effectively from the generation of harm.
Furthermore, by monitoring the change of creatinine content in hemodialysis dialyzate on-line, can in time find dialyzer breakage.
When hollow-fibre membrane such as dialyzer occurs damaged, the creatinine content in dialyzate can be significantly improved, can be timely by monitoring
It was found that dialyzer is damaged, the generation of accident is processed and avoided in time.
Prior art is prevented using electrical conductivity detection, dialysate concentration monitoring etc., but there is also certain shortcoming, such as
The promptness of sampling detection is not enough and generation is polluted, the high-precision sensor of concentration monitor needs, sensor probe may occur
Corrosion phenomenon and generation situations such as cause measured value inaccurate.
Near-infrared spectrum technique is the new technique for just growing up in recent years, is quickly to scan thing near infrared spectrometer
A kind of Instrumental Analysis means of the matter in the reflection, diffusing reflection or transmitted spectrum of 670~2526nm SPECTRAL REGIONs.Due near infrared light
Spectral analysis technology has that analyze speed is fast, efficiency high, sample are without chemical contamination, without sample pretreatment, online Non-Destructive Testing etc.
Advantage, is widely applied in fields such as food and agricultural products detections at present.But literature search does not find that it is applied to blood
Dialysis on-line monitoring field.
Therefore the advantage of Near Infrared Spectroscopy Detection Technology how is combined, the change of creatinine content in on-line monitoring hemodialysis dialyzate
Change, find hemodialysis when dialyzate in creatinine content Changing Pattern, find hemodialysis when dialyzate in creatinine content change and patient
Correlation between heart rate, blood pressure, dialysis blood flow, creatinine content is in special circumstances such as blocking or damaged in finding dialyzate
Under Changing Pattern, one of the problem as the area research.
The content of the invention
The present invention is to solve the problems, such as prior art, there is provided creatinine content on-line monitoring in a kind of hemodialysis dialyzate
Method and system, set up dialysate samples testing model and monitor creatinine in hemodialysis dialyzate on-line using near infrared spectrometer
Changes of contents, reaches the purpose that prevention hemodialysis accident occurs, improves treatment of kidney disease level.
The present invention provides creatinine content on-line monitoring method in a kind of hemodialysis dialyzate, comprises the following steps：
1) the hemodialysis dialysate samples of different creatinine contents are prepared；
2) spectra collection is carried out to above-mentioned dialysate samples using near infrared spectrometer；
3) set up creatinine content in the hemodialysis dialyzate based near infrared spectrum and quantitatively differentiate model；
4) near infrared spectra collection is carried out to hemodialysis dialyzer outlet dialyzate using on-line monitoring probe, it is saturating by what is gathered
Near infrared spectrum and the step 3 of creatinine content in parser outlet dialyzate) creatinine content quantitatively differentiates mould in the dialyzate set up
Type is compared, and determines the creatinine content in dialyzer outlet dialyzate to be checked.
In addition, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, including, blood side is followed
Ring, dialysis fluid side circulation and dialyzer 4；The circulation of blood side includes that human body artery blood outlet side 1, blood pump 2, arterial blood is followed
Ring conduit 3, venous blood circulation conduit 6 and human vein blood input side 8；Arterial circulation conduit 3 connects human body artery
The blood entry port of blood outlet side 1 and dialyzer 4, blood pump 2 is arranged on arterial circulation conduit 3；Venous blood circulation is led
The blood outlet of the connection dialyzer 4 of pipe 6 and human vein blood input side 8；Dialysis fluid side is circulated to be included, dialyzate bucket 9, dialysis
It is liquid pump 10, dialyzate inlet line 11, dialyzate monitoring probe 14, dialyzate outlet line 13, dialyzate recycling bin 15, near red
External spectrum detection data circuit 16, near infrared light spectrum monitoring instrument 17；The connection dialyzate of dialyzate inlet line 11 bucket 9 and dialyzer
4 dialyzate entrance, dialysis liquid pump 10 is arranged in dialyzate inlet line 11；Dialyzate outlet line 13 connects dialyzer 4
Dialyzate outlet and dialyzate recycling bin 15；Dialyzate monitoring probe 14 is arranged on dialyzate outlet line 13, near-infrared
Spectral detection data circuit 16 connection dialyzate monitoring probe 14 and near infrared light spectrum monitoring instrument 17；Dialyzate monitoring probe 14 is adopted
Collect the near infrared spectrum of the creatinine content from the dialyzate out of dialyzer 4.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, with following feature：
The near infrared spectrum of the creatinine content from the acquisition dialyzate of dialyzate monitoring probe 14 of near infrared light spectrum monitoring instrument 17, based near red
Creatinine content quantitatively differentiates that model is compared and obtains in hemodialysis dialyzate creatinine content and remember in real time in the hemodialysis dialyzate of external spectrum
Record.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, with following feature：
In hemodialysis dialyzate based near infrared spectrum creatinine content quantitatively differentiate model refer to prepare different creatinine contents hemodialysis it is saturating
The dialysate samples are carried out spectra collection, so as to set up based near infrared spectrum by analysis liquid sample using near infrared spectrometer
Hemodialysis dialyzate in creatinine content quantitatively differentiate model.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, with following feature：
Creatinine content on-line monitoring system is provided with bubble capture monitor 7 in hemodialysis dialyzate, is arranged on venous blood circulation conduit 6
On.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, with following feature：
Dialyzate monitoring probe 14 includes probing shell 21, dialyzate passage 24, near-infrared receiving chamber 29 and near infrared emission room 32；Closely
Infrared receiver room 29 and near infrared emission room 32 are respectively provided at the both sides of probing shell 21, middle to run through probe by dialyzate passage 24
Housing 21, near-infrared receiving chamber 29 and near infrared emission room 32 are connected by near-infrared receiving batter 25 and near infrared emission hole 30 respectively
Logical dialyzate passage 24, near-infrared receiving batter 25 and near infrared emission hole 30 are coaxial；Near infrared emission room 32 is near infrared emission
The position in hole 30 is provided near infrared emission pipe 31；Near-infrared receiving chamber 29 is provided with near-infrared receiving in the position of near-infrared receiving batter 25
Closed tube 27；Near-infrared receiving chamber 29 is provided with circuit board 28 and is connected with near-infrared receiving closed tube 27；Dialyzate passage 24 is saturating with dialyzer 4
Analysis liquid is exported or dialyzate outlet line 13 is connected and be transported to used dialyzate recycling bin 15；It is provided with outside probing shell 21
Connector 23, connector 23 connects near-infrared receiving chamber 29, near infrared emission room 32 and outside by wire guide 22；Dialyzate leads to
Road 24 is provided with the covering near-infrared receiving of quartz glass 33 batter 25 and near infrared emission hole 30；Dialyzate monitoring probe 14 also includes two
The connection probing shell 21 of individual closure 26 forms near-infrared receiving chamber 29 and near infrared emission room 32 respectively；Near infrared light is monitored
Dialyzate in dialyzate passage 24, the spectral signal of collection through dialyzate monitoring 14 inner leads of probe by connector 23 from
Conduit is drawn, and creatinine in hemodialysis dialyzate is obtained through near infrared spectrum detection data circuit 16, near infrared light spectrum monitoring instrument 17
Content and real time record.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, with following feature：
Closure 26 is threadedly coupled with probing shell 21 by sealing.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, with following feature：
Connector 23, probing shell 21 and closure 26 use stainless steel.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, with following feature：
Dialyzate near infrared light normal transmission dialyzate passage 24.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, with following feature：
Creatinine content on-line monitoring system is provided with heparin pump 20 and is arranged on arterial circulation conduit 3 in hemodialysis dialyzate；Prepare
Parenteral solution injects blood through heparin pump 20.
Unaccounted technical characteristic and experimental procedure etc. are supporting using being carried out in ripe prior art in the present invention.
The beneficial effect of the invention
1st, by the content of creatinine in on-line real time monitoring dialyzate, can quickly judge dialyzer whether occur block or
Disrepair phenomenon, so as to process, prevent the generation of malpractice in time；
2nd, the detection time of on-line monitoring is short, and creatinine content data are more in the dialyzate of acquisition, when helping to find out hemodialysis
The Changing Pattern of creatinine content in dialyzate, when helping to search out hemodialysis in dialyzate creatinine content change with Heart Rate,
Correlation between blood pressure, dialysis blood flow, so that for the treatment of uremic patient provides scientific basis；
3rd, Fast nondestructive evaluation is really realized, compared with other monitoring methods, human error and systematic error are effectively reduced,
Model accuracy rate is high, improves operating efficiency；
4th, it is the prevention of ephrosis, treatment, first aid provide reliable technology and ensure that economy, social effect are huge.
Brief description of the drawings
Fig. 1 is creatinine content on-line monitoring system schematic diagram in a kind of hemodialysis dialyzate of the invention.
Fig. 2 is the structural representation of the dialyzate monitoring probe in the present invention.
Reference:
1- human body artery blood outlet sides；2- blood pumps；3- arterial circulation conduits；4- dialyzers；5- hollow-fibre membranes；
6- venous blood circulation conduits；7- bubble capture monitors；8- human vein blood input sides；The clean dialyzate buckets of 9-；10- is saturating
Analysis liquid pump；11- dialyzate inlet lines；12- dialyzer dialysis fluid sides；13- dialyzate outlet lines；The monitoring of 14- dialyzates is visited
Head；The used dialyzate recycling bins of 15-；16- near infrared spectrum detection data circuits；17- near infrared light spectrum monitoring instruments；20- livers
Plain pump；21- probing shells；22- wire guides；23- connectors；24- dialyzate passages；25- near-infrared receiving batters；26- closures；
27- near-infrared receiving closed tubes；28- circuit boards；29- near-infrared receiving chambers；30- near infrared emissions hole；31- near infrared emission pipes；32-
Near infrared emission room；33- quartz glass.
Specific embodiment
The present invention will be further described with specific embodiment below in conjunction with the accompanying drawings.
A kind of creatinine content on-line monitoring method in hemodialysis dialyzate, the method comprises the following steps：
1) the hemodialysis dialysate samples of different creatinine contents are prepared, sample size meets sets up wanting for Sample model
Ask；
2) spectra collection is carried out to above-mentioned dialysate samples using near infrared spectrometer；
3) set up creatinine content in the hemodialysis dialyzate based near infrared spectrum and quantitatively differentiate model；
4) near infrared spectra collection is carried out to hemodialysis dialyzer outlet dialyzate using on-line monitoring probe, it is saturating by what is gathered
Near infrared spectrum and the step 3 of creatinine content in parser outlet dialyzate) creatinine content quantitatively differentiates mould in the dialyzate set up
Type is compared, and quickly determines the creatinine content in dialyzer outlet dialyzate to be checked.
Fig. 1 is creatinine content on-line monitoring system schematic diagram in a kind of hemodialysis dialyzate of the invention.
As shown in figure 1, creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, including, the circulation of blood side, dialyzate
Circulate and dialyzer 4 side.Dialyzer 4 has hollow-fibre membrane 5 and dialysis fluid side 12.
The circulation of blood side includes that human body artery blood outlet side 1, blood pump 2, the venous blood of arterial circulation conduit 3 are followed
Ring conduit 6 and human vein blood input side 8.The connection human body artery blood of arterial circulation conduit 3 outlet side 1 and dialyzer
4 blood entry port, blood pump 2 is arranged on arterial circulation conduit 3；Venous blood circulation conduit 6 connects the blood of dialyzer 4
Outlet and human vein blood input side 8.
Dialysis fluid side circulation includes that dialyzate bucket 9, dialysis liquid pump 10, the monitoring of dialyzate inlet line 11, dialyzate are popped one's head in
14th, the dialyzate recycling bin 15 of dialyzate outlet line 13, near infrared spectrum detection data circuit 16 and near infrared light spectrum monitoring instrument
17.The dialyzate entrance of the connection dialyzate of dialyzate inlet line 11 bucket 9 and dialyzer 4, dialysis liquid pump 10 is arranged on dialyzate
In inlet line 11；The dialyzate outlet of the connection dialyzer 4 of dialyzate outlet line 13 and dialyzate recycling bin 15；Dialyzate is supervised
Probing first 14 is arranged on dialyzate outlet line 13, the connection dialyzate monitoring of near infrared spectrum detection data circuit 16 probe 14
With near infrared light spectrum monitoring instrument 17；The collection of dialyzate monitoring probe 14 from the dialyzate out of dialyzer 4 creatinine content it is near
Infrared spectrum；The near infrared light of the creatinine content from the acquisition dialyzate of dialyzate monitoring probe 14 of near infrared light spectrum monitoring instrument 17
Spectrum, in the hemodialysis dialyzate based near infrared spectrum creatinine content quantitatively differentiate model compare obtain hemodialysis dialyzate in creatinine contain
Measure and real time record.
Creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, also including bubble capture monitor 7 and heparin pump 20.
Bubble capture monitor 7 is arranged on venous blood circulation conduit 6.Heparin pump 20 is arranged on arterial circulation conduit 3.
The workflow of creatinine content on-line monitoring system in a kind of hemodialysis dialyzate：The human body artery blood of blood side circulation
The blood of the output of liquid outlet side 1 enters dialyzer 4 through blood pump 2, arterial circulation conduit 3, and blood is through hollow in dialyzer 4
Tunica fibrosa 5 carries out solute and exchanges with dialyzate, then returns to people through venous blood circulation conduit 6, human vein blood input side 8
Body；Dialyzate in the clean dialyzate bucket 9 of dialysis fluid side circulation enters dialysis through dialyse liquid pump 10, dialyzate inlet line 11
Device dialysis fluid side 12, carries out solute and exchanges with the blood in hollow-fibre membrane 5, then through the dialyzate in dialyzate monitoring probe 14
Passage, dialyzate outlet line 13 enter used dialyzate recycling bin 15；The collection of dialyzate monitoring probe 14 goes out from dialyzer 4
The near infrared spectrum of the dialyzate for coming, through near infrared spectrum detection data circuit 16, near infrared light spectrum monitoring instrument 17, with based near
Creatinine content quantitatively differentiates that model is compared and obtains in hemodialysis dialyzate creatinine content and in real time in the hemodialysis dialyzate of infrared spectrum
Record.
Creatinine content quantitatively differentiates that model refers to prepare different creatinine contents in hemodialysis dialyzate based near infrared spectrum
Hemodialysis dialysate samples, spectra collection is carried out to the dialysate samples using near infrared spectrometer, so as to set up based near
Creatinine content quantitatively differentiates model in the hemodialysis dialyzate of infrared spectrum.
It is defeated through venous blood circulation conduit 6, bubble capture monitor 7, human vein blood from the blood out of dialyzer 4
Enter side 8 and return to human body.
The blood of the output of human body artery blood outlet side 1 enters saturating through blood pump 2, heparin pump 20, arterial circulation conduit 3
Parser 4；The parenteral solution of preparation injects blood through heparin pump 20.
Fig. 2 is the structural representation of the dialyzate monitoring probe in the present invention.
As shown in Fig. 2 dialyzate monitoring probe 14 includes probing shell 21, dialyzate passage 24, near-infrared receiving chamber 29
With near infrared emission room 32；Near-infrared receiving chamber 29 and near infrared emission room 32 are respectively provided at the both sides of probing shell 21, it is middle by
Dialyzate passage 24 runs through probing shell 21, and near-infrared receiving chamber 29 and near infrared emission room 32 pass through near-infrared receiving batter respectively
25 connect dialyzate passage 24 near infrared emission hole 30, and near-infrared receiving batter 25 and near infrared emission hole 30 are coaxial；Near-infrared
Bay 32 is provided near infrared emission pipe 31 in the position near infrared emission hole 30；Near-infrared receiving chamber 29 is in near-infrared receiving batter
25 position is provided with near-infrared receiving closed tube 27；Near-infrared receiving chamber 29 is provided with circuit board 28 and is connected with near-infrared receiving closed tube 27；Thoroughly
Analysis liquid passage 24 is exported with the dialyzate of dialyzer 4 or dialyzate outlet line 13 is connected and be transported to used dialyzate recycling bin
15。
It is provided with connector 23 outside probing shell 21, connector 23 connects near-infrared receiving chamber 29, near by wire guide 22
Infrared emission room 32 and outside；Dialyzate passage 24 is provided with the covering near-infrared receiving of quartz glass 33 batter 25 and near infrared emission hole
30；Dialyzate monitoring probe 14 also includes that two closures 26 connection probing shells 21 form near-infrared receiving chamber 29 and closely respectively
Infrared emission room 32.
Dialyzate near infrared light monitoring dialyzate passage 24, the spectral signal of collection is through dialyzate monitoring probe 14
Inner lead is drawn by connector 23 from conduit, through near infrared spectrum detection data circuit 16, near infrared light spectrum monitoring instrument
17 obtain creatinine content and real time record in hemodialysis dialyzate.
Closure 26 is threadedly coupled with probing shell 21 by sealing.
Connector 23, probing shell 21 and closure 26 use stainless steel.
Dialyzate near infrared light normal transmission dialyzate passage 24.
Unaccounted technical characteristic and experimental procedure etc. are supporting using being carried out in ripe prior art in the present invention.
Although the present invention is disclosed as above with preferred embodiment, they be not for limiting the present invention, it is any to be familiar with
This area technical professional, without departing from the spirit and scope of the invention, change, remodeling, addition or the replacement made,
Still fall within the protection domain of technical solution of the present invention.
Claims (10)
1. creatinine content on-line monitoring method in a kind of hemodialysis dialyzate, it is characterised in that：Comprise the following steps；
1) the hemodialysis dialysate samples of different creatinine contents are prepared；
2) spectra collection is carried out to above-mentioned dialysate samples using near infrared spectrometer；
3) set up creatinine content in the hemodialysis dialyzate based near infrared spectrum and quantitatively differentiate model；
4) near infrared spectra collection is carried out to hemodialysis dialyzer outlet dialyzate using on-line monitoring probe, the dialyzer that will be gathered
Near infrared spectrum and the step 3 of creatinine content in outlet dialyzate) foundation dialyzate in creatinine content quantitatively differentiate that model enters
Row is compared, and determines the creatinine content in dialyzer outlet dialyzate to be checked.
2. creatinine content on-line monitoring system in a kind of hemodialysis dialyzate, it is characterised in that：Including the circulation of blood side, dialyzate
Circulate and dialyzer (4) side；
Described blood side circulation includes that human body artery blood outlet side (1), blood pump (2), arterial circulation conduit (3) are quiet
Arteries and veins blood circulation conduit (6) and human vein blood input side (8)；The arterial circulation conduit (3) connects the human body
The blood entry port of arterial blood outlet side (1) and the dialyzer (4), the blood pump (2) is arranged on the arterial circulation
On conduit (3)；The venous blood circulation conduit (6) connects the blood outlet of the dialyzer (4) and the human vein blood
Liquid input side (8)；
Described dialysis fluid side is circulated to be included, dialyzate bucket (9), dialysis liquid pump (10), dialyzate inlet line (11), dialyzate
Monitoring probe (14), dialyzate outlet line (13) dialyzate recycling bin (15), near infrared spectrum detection data circuit (16) and
Near infrared light spectrum monitoring instrument (17)；The dialyzate inlet line (11) connects dialyzate bucket (9) and the dialyzer (4)
Dialyzate entrance, the dialysis liquid pump (10) is arranged on the dialyzate inlet line (11)；The dialyzate outlet
Line (13) connects the dialyzate outlet of the dialyzer (4) and the dialyzate recycling bin (15)；The dialyzate monitoring probe
(14) it is arranged on the dialyzate outlet line (13), the near infrared spectrum detection data circuit (16) connects the dialysis
Liquid monitoring probe (14) and the near infrared light spectrum monitoring instrument (17)；Dialyzate monitoring probe (14) is gathered from the dialysis
The near infrared spectrum of creatinine content in device (4) dialyzate out.
3. creatinine content on-line monitoring system in hemodialysis dialyzate according to claim 2, it is characterised in that：
The near infrared light spectrum monitoring instrument (17) from the dialyzate monitoring probe (14) obtain dialyzate in creatinine content it is near
Infrared spectrum, during creatinine content quantitatively differentiates that model is compared and obtains hemodialysis dialyzate in the hemodialysis dialyzate based near infrared spectrum
Creatinine content and real time record.
4. creatinine content on-line monitoring system in hemodialysis dialyzate according to claim 2, it is characterised in that：
Creatinine content quantitatively differentiates that model refers to prepare different creatinines to contain in the described hemodialysis dialyzate based near infrared spectrum
The dialysate samples are carried out spectra collection by the hemodialysis dialysate samples of amount using near infrared spectrometer, are based on so as to set up
Creatinine content quantitatively differentiates model in the hemodialysis dialyzate of near infrared spectrum.
5. creatinine content on-line monitoring system in hemodialysis dialyzate according to claim 2, it is characterised in that：
Creatinine content on-line monitoring system is provided with bubble capture monitor (7) in described hemodialysis dialyzate, is arranged on venous blood
Liquid circulation conduit (6), on.
6. creatinine content on-line monitoring system in hemodialysis dialyzate according to claim 2, it is characterised in that：
Described dialyzate monitoring probe (14) includes probing shell (21), dialyzate passage (24), near-infrared receiving chamber (29)
With near infrared emission room (32)；The near-infrared receiving chamber (29) and near infrared emission room (32) are respectively provided at probing shell (21)
Both sides, it is middle by dialyzate passage (24) through probing shell (21), near-infrared receiving chamber (29) and near infrared emission room (32)
Dialyzate passage (24), near-infrared receiving batter (25) are connected near infrared emission hole (30) by near-infrared receiving batter (25) respectively
It is coaxial near infrared emission hole (30)；The near infrared emission room (32) is provided with near-infrared in the position of near infrared emission hole (30)
Transmitting tube (31)；Described near-infrared receiving chamber (29) is provided with near-infrared receiving closed tube in the position of near-infrared receiving batter (25)
(27)；Described near-infrared receiving chamber (29) is provided with circuit board (28) and is connected with near-infrared receiving closed tube (27)；Described dialyzate
Passage (24) is exported with dialyzer (4) dialyzate or dialyzate outlet line (13) is connected and is transported to used dialyzate reclaims
Bucket (15)；
Connector (23) is provided with outside described probing shell (21), the connector (23) connects near red by wire guide (22)
Outer receiving chamber (29), near infrared emission room (32) and outside；Described dialyzate passage (24) is provided with quartz glass (33) covering
Near-infrared receiving batter (25) and near infrared emission hole (30)；Described dialyzate monitoring probe (14) also includes two closures
(26) connection probing shell (21), forms near-infrared receiving chamber (29) and near infrared emission room (32) respectively；
Near infrared light monitors the dialyzate in dialyzate passage (24), and the spectral signal of collection is through dialyzate monitoring probe (14)
Inner lead is drawn by connector (23) from conduit, is supervised through near infrared spectrum detection data circuit (16), near infrared spectrum
Survey instrument (17) and obtain creatinine content and real time record in hemodialysis dialyzate.
7. creatinine content on-line monitoring system in hemodialysis dialyzate according to claim 6, it is characterised in that：
Described closure (26) is threadedly coupled with probing shell (21) by sealing.
8. creatinine content on-line monitoring system in hemodialysis dialyzate according to claim 5, it is characterised in that：
Described connector (23), probing shell (21) and closure (26) use stainless steel.
9. creatinine content on-line monitoring system in hemodialysis dialyzate according to claim 6, it is characterised in that：
Dialyzate in described near infrared light normal transmission dialyzate passage (24).
10. creatinine content on-line monitoring system in hemodialysis dialyzate according to claim 2, it is characterised in that：
Creatinine content on-line monitoring system is provided with heparin pump (20) in described hemodialysis dialyzate, is arranged on arterial circulation and leads
On pipe (3)；The parenteral solution of preparation injects blood through heparin pump (20).
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| CN201710283937.8A CN106918573B (en) | 2017-04-26 | 2017-04-26 | Online monitoring method and system for creatinine content in hemodialysis dialysate |
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| CN201710283937.8A CN106918573B (en) | 2017-04-26 | 2017-04-26 | Online monitoring method and system for creatinine content in hemodialysis dialysate |
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| CN106918573B CN106918573B (en) | 2023-06-13 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107561038A (en) * | 2017-09-07 | 2018-01-09 | 郑州大学第附属医院 | Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate |
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| CN2386827Y (en) * | 1998-09-11 | 2000-07-12 | 彭罗民 | Automatic blood dialyser |
| US20050101901A1 (en) * | 2001-11-16 | 2005-05-12 | Victor Gura | Wearable continuous renal replacement therapy device |
| DE102011101193A1 (en) * | 2011-05-11 | 2012-11-15 | Ldiamon As | Method and detection device for determining the uric acid and creatinine content |
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| CN2386827Y (en) * | 1998-09-11 | 2000-07-12 | 彭罗民 | Automatic blood dialyser |
| US20050101901A1 (en) * | 2001-11-16 | 2005-05-12 | Victor Gura | Wearable continuous renal replacement therapy device |
| DE102011101193A1 (en) * | 2011-05-11 | 2012-11-15 | Ldiamon As | Method and detection device for determining the uric acid and creatinine content |
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| CN107561038A (en) * | 2017-09-07 | 2018-01-09 | 郑州大学第附属医院 | Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate |
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| CN106918573B (en) | 2023-06-13 |
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