CN106901749A - A kind of extracting method of cortex hemoglobin information representation locomitivity parameter - Google Patents
A kind of extracting method of cortex hemoglobin information representation locomitivity parameter Download PDFInfo
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- CN106901749A CN106901749A CN201710009872.8A CN201710009872A CN106901749A CN 106901749 A CN106901749 A CN 106901749A CN 201710009872 A CN201710009872 A CN 201710009872A CN 106901749 A CN106901749 A CN 106901749A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4842—Monitoring progression or stage of a disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
Abstract
The invention discloses a kind of extracting method of cortex hemoglobin information representation locomitivity parameter, its step includes：(1) patients with cerebral apoplexy is performed and refers to nose and with knee footpath exercise testing：Strong side and Ipsilateral upper and lower extremities are successively respectively completed motion, the starting of patient's autonomous control motion and the time of having a rest between end time and two tasks；(2) according to the cortex HC information recorded during motion and during rest, the dispersion degree of oxygen HC is included from each motor function region of phase cerebral cortex before and after the angle analysis Rehabilitation of multiband, and concentration value is positive to enliven frequency range and the variation tendency that concentration value is negative suppression frequency range；(3) running parameter and the active characteristic parameter with suppression frequency range of brain hemoglobin information space difference are found out, the power of patients with cerebral apoplexy locomitivity is characterized.
Description
Technical field
It is more particularly to a kind of to be based on cortex hemoglobin information representation the invention belongs to motion function rehabilitation assessment technology
The extracting method of patients with cerebral apoplexy locomitivity power characteristic parameter.
Background technology
Cerebral apoplexy has become the common disease of China's mid-aged population, with the development of aging population, the morbidity of apoplexy
Rate and the death rate are all greatly increased.China is the first big country of population, is also qualified apoplexy big country, according to newest investigation
Patients with stroke about 2,500,000 is newly sent out every year by data, China, just has within every 12 seconds a people that headstroke, the people that palsy is died from every year occur
Number is more than 1,500,000.The whole nation prevalence of more than 40 years old has reached 2%, and the whole nation is estimated to be more than 700 ten thousand cerebral apoplexy people at present
Mouthful, in the paralytic of survival, about 80% leaves different degrees of deformity, wherein 40% is severe disability.Various motion work(
Can obstacle cause the daily life active ability of patient to be limited, influence patient is socially reintegrated life again, exacerbation family and society
Financial burden.
In time, effective evaluation is treated for the motion function rehabilitation for instructing patients with cerebral apoplexy, evaluates treatment curative effect, prediction
Functional rehabilitation plays the role of important.Current motion function rehabilitation evaluation is main to have subjectivity to evaluate and objectivity evaluation two
Point, the former is more to assess table, motor status scale (Motor Status Scale using Fugl-Meyer：MSS),
Brunnstrom functional evaluation scales, Berg balance evaluation charters etc..Measuring scale assessing extensive use in clinical practice, but its master
The property seen is stronger, it is difficult to accurately reflect patient's function.Biomechanical approach, Electrophysiology and functional MRI are used the latter more
It is strong relative to scale appraisal procedure objectivity etc. assessment system.Especially functional MRI appraisal procedure, can directly test disease
Source information：Brain blood oxygenation information, it has certain superiority in various assessment methods.
However, at present also there is following subject matter in the rehabilitation evaluation method of functional MRI：Function nuclear-magnetism Brian Imaging skill
The temporal resolution of art is low, and body is often confined to inactive state in test process, there is very big binding character, and to magnetic field ring
Border requires higher.Comparatively, functional near-infrared imaging technology (NIRS) have to test environment and subject limitation less,
Under the Nature condition of cognitive activities support for a long time measure, need not largely be trained, with preferable room and time
The advantages of feature of resolution ratio, make it that there is very big advantage in the motor function rehabilitation evaluation research field of cerebral apoplexy.
The content of the invention
Goal of the invention：A kind of extracting method of cortex hemoglobin information representation locomitivity parameter is proposed, using non-
Intrusive mood NIRS technical noteses patients with cerebral apoplexy is performed and refers to nose and with the Cerebral cortex hemoglobin information in the experimentation of knee footpath, is made
Obtain the motion of patient's autonomous control to be trained without environmental stimuli and early stage, realize suffering to being more beneficial for reaction under proper motion situation
The tracking measurement of the brain hemoglobin information of the locomitivity of person, be based on brain biological information evaluation cerebral apoplexy motor function simultaneously
Important theoretical foundation has been established in pointedly auxiliary treatment and prediction.
To achieve these goals, the present invention provides following technical scheme：
A kind of extracting method of cortex hemoglobin information representation locomitivity parameter, its step includes：
1st, patients with cerebral apoplexy is performed and refers to nose and with knee footpath exercise testing：Strong side and Ipsilateral upper and lower extremities are successively respectively completed fortune
Dynamic, the starting of patient's autonomous control motion and the time of having a rest between end time and two tasks, (explanation in advance will be as far as possible
It is long：More than 30s, and being practised, but requirement can not number)；
2nd, according to the cortex HC information recorded during motion and during rest, from the angle of multiband
Each motor function region of phase cerebral cortex includes the dispersion degree of oxygen HC before and after degree analysis Rehabilitation, and
Active (concentration value is for just) and the variation tendency for suppressing (concentration value is negative) frequency range；
3rd, the running parameter and the active characteristic parameter with suppression frequency range of brain hemoglobin information space difference are found out,
Characterize the power of patients with cerebral apoplexy locomitivity.
Beneficial effect of the present invention：
1. test can be carried out during real autokinetic movement using NIRS brains technology for information acquisition, brain is increased
Biological information reacts the confidence level of locomitivity, it is ensured that the reality of the brain hemoglobin information evaluation locomitivity in application dynamic
With value.
2. multiple frequency ranges analysis Cerebral cortex hemoglobin information are divided, active frequency that can be during longitudinal 2 observation Rehabilitation
Section transfer case, highlights the distribution characteristics of area of space under each specific frequency range, is conducive to finding out the allusion quotation for characterizing locomitivity
Type feature, be accurately evaluate patients with cerebral apoplexy athletic rehabilitation situation and be given immunotherapy targeted autoantibody or rehabilitation training suggestion establish
Important early stage basis.
3. based on space function region relative different and a certain region parameter of non-specific is not limited to a certain as feature
The specific cause of disease or lesions position, can increase range of application.
Brief description of the drawings
Fig. 1 is the experiment campaign timing diagram of this method；
Fig. 2 is this method deutocerebrum cortex TCH test channel and motor function region distribution map；
Fig. 3 is patients with cerebral apoplexy locomitivity enhancing process frequency range transfer schematic diagram in this method.
Specific embodiment
Embodiment：
1st, patients with cerebral apoplexy is performed and refers to nose and with knee footpath exercise testing, and strong side and Ipsilateral upper and lower extremities are successively respectively completed fortune
It is dynamic, the initial and time of having a rest between end time and two tasks of patient's autonomous control motion；
Refer to nose task (T1)：Arm nature is positioned over body both sides first, first upper limbs arm is raised up in face of, use
Forefinger points to nose, then arm is replaced and is ended task；
With knee footpath task (T2)：Sitting posture (is sat in bed or on other platforms), and lower limb are horizontal positioned state when initial,
Leg will first be moved and lift the knee position for being placed on motionless leg, motion leg is slowly slided into raw water along the shank of motionless leg afterwards
Prosposition is put and is ended task.
First to the whole flow process and points for attention of subject's explanation experiment, in its natural state, a bottom left is successively familiar with
The finger nose of right side limbs and with the experiment of knee footpath action；Wherein patient tries one's best to perform according to the actual motion ability of oneself and appoints
Business, even the minute movement of arm is considered as performing inter-related task, rather than requiring to complete to refer to nose or with knee
Footpath experiment action.
Experiment idiographic flow (as shown in Figure 1)：Before task starts, it is tested and keeps quiescent condition rear beginning in 2 minutes or so
Refer to nose task, left and right limbs are front and rear to be performed and be repeated four times；Perform lower limb afterwards slides task with knee footpath, is equally left and right limb
Performed before and after body and be repeated four times；Sufficiently rested between each two task, task segment and rest section are alternately.Each
Beginning and end moment of task, movement velocity and time of having a rest are controlled by patient oneself completely, the fortune in spontaneous control
Dynamic state, but inform that patient rests the enough time before experiment, at least more than 30 seconds (but can not be controlled by several
System).
Patient successively performs 3 exercise testings, and experimental period is in the first month of cerebral apoplexy, afterwards at interval of 2- first
Carry out within 3 weeks identical motion pick experiment next time；Meanwhile, it is interior one day after before each exercise testing to have specialist for upper and lower
Limb locomitivity is estimated；Data are carried out from locomitivity in each test process than the make progress patient of raising of last time
Analysis.
2nd, according to the cortex HC information recorded during motion and during rest, from the angle of multiband
Each motor function region of phase cerebral cortex includes the dispersion degree of oxygen HC before and after degree analysis Rehabilitation, and
The active variation tendency with suppression frequency range：
In whole experiment process, using the tested blood red egg of cortex of near infrared light Brian Imaging equipment FORIE-3000 collections
White information, the cortex motor function region of test and TCH test channel, headgear transmitting probe, receiving transducer distribution map such as Fig. 2 institutes
Show；The another beginning and end moment (MARK) for thering is experiment operator to mark each task of patient；Headgear layout method：Using state
Border 10-20 system standard electrode positioning modes determine crown central point CZ, and the 7th transmitting probe of headgear is positioned over into CZ positions, the 2nd
Transmitting probe is just to nose direction；The scope tested includes that 22 TCH test channels (lead in Fig. 2 by the different test of digitized representation
Road, the different probe transmitting terminal of the digitized representation with circle or triangle or probe receiving terminal), what each TCH test channel was tested
Information includes oxygenated blood Lactoferrin, deoxyhemoglobin and total oxygen HC, the analysis process oxygen-containing hemoglobin of sampling
As Main Analysis parameter.
The motor function region includes：Motion auxiliary region (SMA), left side premotor area (L-PMC), right side premotor area
(R-PMC), center main motion control zone (M-SMC), left side main motion control zone (L-SMC) and right side main motion control zone (R-
SMC)；
Specific steps include：
1. the oxygen-containing hemoglobin information for each TCH test channel carries out power spectral-density analysis, determines all motions
The corresponding frequency range of main power of each TCH test channel is respectively less than equal to 0.15Hz in functional area；
2. the oxygen-containing hemoglobin that each TCH test channel in each motor function region is calculated for each sampling instant is put down
Average, further carries out WAVELET PACKET DECOMPOSITION to the information in each region using sym4 wavelet basis, and Decomposition order is 8 layers, corresponding
Minimum frequency range is at intervals of 0.015Hz；The Energy distribution percentage of each frequency is calculated based on wavelet coefficient, and to successively three motions
The test data of experiment calculates energy percentage respectively, the frequency distribution feature of main energetic during longitudinal 2 observation athletic rehabilitation
(as shown in Figure 3), can analyze and draw, with the rehabilitation of locomitivity, the frequency range changes in distribution process of main energetic is：Noenergy
Collection Mid Frequency concentrates on 0.1-0.12Hz → 0.06-0.09Hz → 0.015-0.06Hz, and main energetic value is in incremental rule
Rule.
3. ten frequency range wavelet coefficients based on below 0.15Hz perform wavelet reconstruction, are based further on the weight of each frequency range
Structure timing information, calculates the motor function region sequential average value of each task segment.
4. the variation lines in each frequency range between each motor function region are calculated for test data before and after Rehabilitation
Number, the size variation of the coefficient of variation of each frequency range and frequency range distribution characteristics, can analyze during longitudinal 2 observation athletic rehabilitation
Go out, with the rehabilitation of locomitivity, the numerical discretization degree in each frequency range between regional tapers off rule.
3rd, the running parameter and the active characteristic parameter with suppression frequency range of brain hemoglobin information space difference are found out,
Characterize the power of patients with cerebral apoplexy locomitivity：
By analyzing the distribution characteristics of each interregional coefficient of variation and the energy size of each frequency range and energy in each frequency range
Amount percentage (table 1), confirm energy percentage occupy value for coefficient of variation in two band limits of front two, corresponding band with
And the average energy value can be used to characterize the recovery process of locomitivity；Two are enlivened adjacent frequency bands and concentrate on low-frequency range 0.015-
Between 0.06Hz, while the coefficient of variation is smaller, represent that locomitivity is recovered better；Suppress frequency range main band limits also with
The recovery for locomitivity is shifted to low frequency segment limit (0-0.03Hz), and, suppress frequency range and enliven the frequency range between frequency range
Spacing is successively decreased also with rehabilitation course.
Variation difference during the enhancing of the patients with cerebral apoplexy locomitivity of table 1 between each frequency range inner region
Note：Positive negative energy calculates percentage respectively, and negative sign represents that numerical value accounts for the percentage of negative value summation, and positive sign represents numerical value
Account for the percentage on the occasion of summation.Underline font styles represent frequency range more than energy percentage >=20%.
Claims (4)
1. a kind of extracting method of cortex hemoglobin information representation locomitivity parameter, it is characterised in that its step includes：
(1) patients with cerebral apoplexy is performed and refers to nose and with knee footpath exercise testing：Strong side and Ipsilateral upper and lower extremities are successively respectively completed motion, suffer from
The starting of person's autonomous control motion and the time of having a rest between end time and two tasks；
(2) according to the cortex HC information recorded during motion and during rest, from the angle of multiband
Each motor function region of phase cerebral cortex includes the dispersion degree of oxygen HC, Yi Jinong before and after analysis Rehabilitation
Angle value is positive to enliven frequency range and the variation tendency that concentration value is negative suppression frequency range；
(3) running parameter and the active characteristic parameter with suppression frequency range of brain hemoglobin information space difference, table are found out
Levy the power of patients with cerebral apoplexy locomitivity.
2. the extracting method of cortex hemoglobin information representation locomitivity parameter according to claim 1, its feature
It is, in step (1),
The finger nose task refers to that arm nature is positioned over body both sides first, first upper limbs arm is raised up in face of, use
Forefinger points to nose, then arm is replaced and is ended task；
Lower limb are horizontal positioned state when referring to initial sitting posture with knee footpath task, will first move leg and lift the knee for being placed on motionless leg
Lid position, slowly slides into motion leg former horizontal level and ends task along the shank of motionless leg afterwards；
The exercise testing idiographic flow is：It is tested to keep quiescent condition to start to refer to that nose is appointed after 2 minutes or so before task starts
Performed before and after business, left and right limbs and be repeated four times；Perform lower limb afterwards slides task with knee footpath, before and after being equally left and right limbs
Perform and be repeated four times；Sufficiently rested between each two task, task segment and rest section are alternately；Each task
Beginning and end moment, movement velocity and time of having a rest are controlled by patient oneself completely, the motion state in spontaneous control,
But inform that patient rests the enough time before experiment, at least more than 30 seconds；
Patient successively performs 3 exercise testings, and experimental period is in the first month of cerebral apoplexy, afterwards at interval of 2-3 weeks first
Carry out identical motion pick experiment next time；Meanwhile, it is interior one day after before each exercise testing to there is specialist to be directed to upper and lower extremities
Locomitivity is estimated；Data point are carried out from locomitivity in each test process than the make progress patient of raising of last time
Analysis.
3. the extracting method of cortex hemoglobin information representation locomitivity parameter according to claim 1, its feature
It is, in step (2),
Using the tested cortex hemoglobin information of near infrared light Brian Imaging equipment FORIE-3000 collections；The motor function
Region includes：Motion auxiliary region, left side premotor area, right side premotor area, center main motion control zone, left side main motion control
Area and right side main motion control zone；Experiment operator marks the beginning and end moment of each task of patient；Using international 10-
20 system standard electrode positioning modes determine crown central point CZ, and the 7th transmitting probe of headgear is positioned over into CZ positions, the 2nd transmitting
Probe is just to nose direction；The scope tested includes 22 TCH test channels, and the information that each TCH test channel is tested includes containing
Oxygen hemoglobin, deoxyhemoglobin and total oxygen HC, analysis process sample oxygen-containing hemoglobin as main point
Analysis parameter；
Specific steps include：
1. the oxygen-containing hemoglobin information for each TCH test channel carries out power spectral-density analysis, determines all motor functions
The corresponding frequency range of main power of each TCH test channel is respectively less than equal to 0.15Hz in region；
2. the oxygen-containing hemoglobin average value of each TCH test channel in each motor function region is calculated for each sampling instant,
WAVELET PACKET DECOMPOSITION is further carried out to the information in each region using sym4 wavelet basis, Decomposition order is 8 layers, corresponding minimum frequency
It is intersegmental to be divided into 0.015Hz；The Energy distribution percentage of each frequency is calculated based on wavelet coefficient, and to three exercise testings of priority
Test data calculates energy percentage respectively, frequency distribution feature (such as Fig. 3 of main energetic during longitudinal 2 observation athletic rehabilitation
It is shown), can analyze and draw, with the rehabilitation of locomitivity, the frequency range changes in distribution process of main energetic is：Noenergy collection intermediate frequency
Section concentrates on 0.1-0.12Hz → 0.06-0.09Hz → 0.015-0.06Hz, and main energetic value is in progressive law；
3. ten frequency range wavelet coefficients based on below 0.15Hz perform wavelet reconstruction, when being based further on the reconstruct of each frequency range
Sequence information, calculates the motor function region sequential average value of each task segment；
4. the coefficient of variation in each frequency range between each motor function region is calculated for test data before and after Rehabilitation, is indulged
To the size variation and frequency range distribution characteristics of the coefficient of variation of each frequency range during observation athletic rehabilitation, can analyze and draw, with
The rehabilitation of locomitivity, the numerical discretization degree in each frequency range between regional tapers off rule.
4. the extracting method of cortex hemoglobin information representation locomitivity parameter according to claim 1, its feature
It is, in step (3),
By analyzing the distribution characteristics of each interregional coefficient of variation and the energy size of each frequency range and energy hundred in each frequency range
Divide ratio, confirm that energy percentage occupy value for coefficient of variation and average energy in two band limits of front two, corresponding band
Value can be used to characterize the recovery process of locomitivity；Two enliven adjacent frequency bands and concentrate on low-frequency range 0.015-0.06Hz it
Between, while the coefficient of variation is smaller, represent that locomitivity is recovered better；Suppress the main band limits of frequency range also with motion energy
The recovery of power is shifted to 0-0.03Hz low frequencies segment limit, and, suppress frequency range and enliven frequency range spacing between frequency range also with
Rehabilitation course successively decreases.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854127A (en) * | 2017-10-30 | 2018-03-30 | 苏州大学 | A kind of detection method and device of motion state |
| CN108042131A (en) * | 2017-12-26 | 2018-05-18 | 武汉智普天创科技有限公司 | The Portable cap of brain electricity and near infrared spectrum Collect jointly brain signal |
| CN108113682A (en) * | 2017-10-31 | 2018-06-05 | 北京心灵方舟科技发展有限公司 | Measure device, the method and apparatus of oxygen-containing hemoglobin and deoxyhemoglobin |
| CN108309318A (en) * | 2018-01-30 | 2018-07-24 | 苏州大学 | Cerebral function state evaluation device based on brain hemoglobin information |
| CN108932403A (en) * | 2018-07-02 | 2018-12-04 | 苏州大学 | Leave and the dynamic recognition methods of fortune based on brain hemoglobin information |
| CN109243569A (en) * | 2018-06-29 | 2019-01-18 | 苏州大学 | The recognition methods of spontaneous phantom object displacement orientation is tested based on brain information identification |
| CN109864745A (en) * | 2019-01-08 | 2019-06-11 | 国家康复辅具研究中心 | A kind of novel risk of stroke appraisal procedure and system |
| CN111281399A (en) * | 2020-02-03 | 2020-06-16 | 国家康复辅具研究中心 | Multi-band physiological signal feedback system based on near infrared and use method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107854127A (en) * | 2017-10-30 | 2018-03-30 | 苏州大学 | A kind of detection method and device of motion state |
| CN108113682A (en) * | 2017-10-31 | 2018-06-05 | 北京心灵方舟科技发展有限公司 | Measure device, the method and apparatus of oxygen-containing hemoglobin and deoxyhemoglobin |
| CN108042131A (en) * | 2017-12-26 | 2018-05-18 | 武汉智普天创科技有限公司 | The Portable cap of brain electricity and near infrared spectrum Collect jointly brain signal |
| CN108309318A (en) * | 2018-01-30 | 2018-07-24 | 苏州大学 | Cerebral function state evaluation device based on brain hemoglobin information |
| CN108309318B (en) * | 2018-01-30 | 2020-06-09 | 苏州布芮恩智能科技有限公司 | Brain functional state evaluation device based on brain hemoglobin information |
| CN109243569A (en) * | 2018-06-29 | 2019-01-18 | 苏州大学 | The recognition methods of spontaneous phantom object displacement orientation is tested based on brain information identification |
| CN108932403A (en) * | 2018-07-02 | 2018-12-04 | 苏州大学 | Leave and the dynamic recognition methods of fortune based on brain hemoglobin information |
| CN108932403B (en) * | 2018-07-02 | 2021-09-14 | 苏州大学 | Brain hemoglobin information-based resting state and movement state identification method |
| CN109864745A (en) * | 2019-01-08 | 2019-06-11 | 国家康复辅具研究中心 | A kind of novel risk of stroke appraisal procedure and system |
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