CN106860860A - The new opplication of polyzyme tablets - Google Patents
The new opplication of polyzyme tablets Download PDFInfo
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- CN106860860A CN106860860A CN201710122430.4A CN201710122430A CN106860860A CN 106860860 A CN106860860 A CN 106860860A CN 201710122430 A CN201710122430 A CN 201710122430A CN 106860860 A CN106860860 A CN 106860860A
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- polyzyme tablets
- polyzyme
- tablets
- nettle rash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/488—Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/23—Aspartic endopeptidases (3.4.23)
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- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
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- Pharmacology & Pharmacy (AREA)
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Abstract
The application of nettle rash and other itching disease medicines is being prevented and treated the present invention relates to polyzyme tablets.Now take antihistamine drug orally, corticoid medicine suppresses nettle rash temporarily, damages kidney, cause a series of metabolisms such as body sugar, protein, fat and Water-Electrolyte disorderly, destroy the defence system of body and suppress immune response ability.And dependence is produced to hormone, primary affection knock-on is aggravated and secondary side effect after drug withdrawal.The present invention by polyzyme tablets treatment nettle rash and other itching disease medicines in applied, similarly also can treatment stomach energy, it is damp and hot, applied in hydrochloric acid in gastric juice medicine, one time 6, three times a day.More preferably, reasonable compatibility, safe edible has no toxic side effect curative effect, instant effect, and low cost does not recur, and can rapidly subtract patient's pain.
Description
Technical field
The present invention relates to the new opplication of polyzyme tablets, particularly in prevention and treatment nettle rash and other itching disease medicines should
With, can also stomach energy be being treated, it is damp and hot, applied in hydrochloric acid in gastric juice medicine.
Background technology
Polyzyme tablets main component is pancreatin, pepsin；Auxiliary material is sucrose and magnesium stearate.Contain pancreas fat in pancreatin
Enzyme, amylopsin, trypsase, pancreatic lipase can make lipolysis for glycerine and aliphatic acid, and amylopsin can make Starch Conversion
It is sugar, trypsase can make protein be converted into peptone;Pepsin can make protein be converted into albumen and peptone.The two
Share, digestion can be promoted, improve a poor appetite.
In addition to above-mentioned application, polyzyme tablets is also using in other medicines：As Chinese patent " CN2007100130202 " is public
" a kind of compound traditional Chinese medicine powder for treating pain in waist and lower extremities " opened, crushed by rhizoma atractylodis, corydalis tuber, golden cypress, vitamin, calcium gluconate tablet and polyzyme tablets,
Sieving, it is hybrid packed.Polyzyme tablets answers full wafer to take, and polyzyme tablets is double-deck sugar coated tablet, and its outer layer is ordinary glazes, and internal layer is
Enteric coatel tablets, the latter can keep out destruction of the hydrochloric acid in gastric juice to enzyme, it is passed through stomach and reach small intestine, discharge active ingredient, play digestion
Effect of enzyme, chewing clothes or take after mashing can all reduce drug effect, or even make drug effect completely without chewing clothes or even also can result in oral cavity and burst
Ulcer.
As Chinese patent " CN951132199 " is disclosed " a kind of quick-acting rush down dysentery health compositions ", by the coptis, the bark of official magnolia, Chinese herbaceous peony
Son, dried orange peel, hawthorn, cacumen biotae, rifampin, polyzyme tablets, nifedipine are made the peroral dosage forms such as ball, piece, oral liquid, electuary, plus
It is various in work to there is a problem of above-mentioned crushing, and polyzyme tablets can not with acidic drug with taking, to avoid when taking vinegar, sauerkraut,
The acidic foods such as hawthorn, red bayberry.
Such as Chinese patent " CN201110249389X " disclosed " a kind of Chinese-western composite medicine for treating tumor disease " and mountain
Short, bristly hair or beard is with taking, and " CN2009101435832 " is disclosed " a kind of to treat the upper respiratory tract and encephalitis B virus cause the Chinese and Western of fever and headache multiple
Close medicine ", polyzyme tablets carries out instillation mode except the technology for employing crushing is made liquid, and also there are problems that compatibility improperly.
Can be drawn by above-mentioned known technology, polyzyme tablets is also carried out in addition to known digestion in other field
New application, one is to apply inadequate, and two is that nettle rash and his application of pruritus are said nothing.
Current doctor trained in Western medicine there is no specific short to nettle rash, uses to take antihistamine drug, corticoid medicine orally more
It is interim to be suppressed to many, such as oral western medicine, oral hormone, externally used solution lotion, emulsion, mud cream, finish, ointment, emulsion, painting
Film, tincture and plaster etc..Long-time or heavy dose of external application use corticoid medicine, and meeting habituation causes drug dependence,
Most commonly sb.'s illness took a favorable turn after medication, and after being discontinued, agents area primary affection is aggravated.It is above-mentioned after hormone is used again
Sb.'s illness took a favorable turn or disappears；It is rebound to send out again as being discontinued again, and than more serious in the past.Patient is in order to avoid the pain after drug withdrawal
Hardship, place one's entire reliance upon hormone.Meeting skin is substantially thinning, and purpura etc. occurs sometimes in telangiectasis, can particularly go out in face
Existing deeper persistent erythema.With the hormone time it is more long, produce rebound allergy also heavier.Thinning of skin, fragility can be made, withered
Contracting, telangiectasis, purpura, fungal infection, acne sample dermatitis etc..Become subject to damage；It may also occur that slight crinosity, many
Sweat, subcutaneous hemorrhage and wound healing difficulty etc..Especially some skin diseases are more not suitable for using steroids preparation.If long-term
Or short time large bolus injection or dexamethasone for oral administration, Kenacort, prednisone isocortex parahormone drug therapy, can also cause
Obesity, crinosity, acne, blood glucose rise, hypertension, oedema, blood potassium reduction, paramenia, osteoporosis, aseptic sclerotin are bad
Extremely, the complication such as gastric and duodenal ulcer.Certain infringement can be also caused to kidney, renal glomerular disease albuminuria is such as aggravated, is added
Glomerulosclerosis, easily cause kidney calcification or calculus, induce or aggravate renal infectious disease, cause low potassium ephrosis etc. again.Can also
Cause a series of metabolisms such as body sugar, protein, fat and Water-Electrolyte disorderly, destroy defence system and the suppression of body
Immune response ability.If patient over the course for the treatment of because use corticoid medicine, and hormone is generated according to
Lai Xing, primary affection knock-on is aggravated and secondary side effect, the pain that patient's generation can be made very big after drug withdrawal.
The content of the invention
The present invention is directed to above-mentioned deficiency, according to the composition of polyzyme tablets, should by numerous studies work, pharmacological evaluation and clinic
With application curative effect of the discovery polyzyme tablets in treatment nettle rash and other pruritus medicines more preferably, reasonable compatibility, safe edible, nothing
Toxic and side effect, instant effect, low cost does not recur, and can rapidly subtract patient's pain.
Application of the polyzyme tablets in treatment nettle rash and other itching disease medicines.
Every contain 300 milligrams of pancreatin, the polyzyme tablets one time that 13 milligrams of pepsin 6, three times a day.
Described polyzyme tablets is in treatment stomach energy, damp and hot, the application in hydrochloric acid in gastric juice medicine.
Traced to its source below according to the cause of disease and be analyzed：
Nettle rash（Urticaria）It is a kind of common skin disease to be commonly called as wheal, rubella group, wheal, and skin and disturb to itch.By each
The factor of kind causes the temporary inflammatory congestion of mucocutaneous blood vessel generation to be oozed out with big quantity of fluid.Cause the infringement of local edema.
It occurs rapidly and disappears, has itching.Can there are fever, stomachache, diarrhoea or other constitutional symptoms.Acute urticaria, slow can be divided into
Property nettle rash, angioneurotic edema and papulosquamous nettle rash etc..Polyzyme tablets is except for treating indigestion, atrophic
Outside the diseases such as gastritis, after being ill stomach hypofunction, diet satiety or abnormal fermentation, it can also reduce fat, and reduce glycerine three in blood
The level of ester, accelerates the esterification of cholesterol, or is broken down into cholic acid, promotes bile excretion, so as to reduce Blood Cholesterol
Content, to prevent the development of fatty liver.Additionally, polyzyme tablets can also influence coagulation process, can reduce blood pressure.Eliminate internal blood-head
Blood is dry, comprehensive decontamination blood, improves skin microcirculation, and eczema, the urticaria sample skin damageds such as oedema, fash, wheal are eliminated rapidly；
It is potent anti-oxidant, improve regulation of blood vessels function, recover body itself blood supply oxygen supply function, it is ensured that the cellular respiration of each histoorgan
It is unimpeded；Human activin itself anti-inflammatory properties, actively eliminate deep skin inflammation and vascular inflammation, and prevent damaged part further
Suffer that extraneous infection deteriorates, prevent and treat the syndrome that eczema, nettle rash induce；Skin toxins, blood poison, dysentery are thoroughly removed, clearly
Except residual toxins such as Western medicine and Chinese medicines, self metabolism of the toxin of damaged part cell and barrier function are activated；Effectively adjust sebum
Secretion, accelerates because of the peeling of the aging cutin and melanin caused after erythema, infection healing, balance skin own metabolism work(
Energy.
Focus is eradicated simultaneously in the case of antipruritic, polyzyme tablets is in treatment nettle rash and other itching disease medicines
Unexpected effect is served in.Principle according to more than, polyzyme tablets similarly can be in treatment stomach energy, damp and hot, hydrochloric acid in gastric juice
Applied in medicine.
Specific embodiment
Clinical trial：Thunder precipitation, female, 35 years old, Wanzhou prefecture of Chongqing people, 2011, there is sheet and does not advise in acute urticaria, skin
Whole red piece, very itches incomparable, and hand scratches show silk, takes polyzyme tablets 6, three times per day, first day, goes to itch, the 3rd day, red piece
Area reduces, and color is thin out, fully recovers within the 4th day, then takes 7 days for consolidation, does not recur so far.
The outstanding person for opening, man, 41 years old, people from Wanzhou District, 2002, chronic urticaria, itching, dermohemia simultaneously had liquid to ooze out,
And with fever, stomachache, symptom of diarrhea.First take antipyretic normal to body temperature, then take polyzyme tablets 6, three times per day, first
Exosmose liquid caking after it, and antidiarrheal is painless；All symptoms disappear within 4th day.Seven days are taken again for consolidation, are not recurred so far.
Fang Yong, man, 32 years old, people from Yunyang, 1999, skin was itched to insomnia without itching because disturbing, and takes polyzyme tablets 6, one day
Three times, symptom disappears after four days.So far do not recur.
Qian Xiaohua, man, 52 years old, damp and hot, stomach energy, stomach violates acid, takes polyzyme tablets 6, and three times per day, symptom disappears after five days
Lose, people's rehabilitation.So far do not recur.
During taking polyzyme tablets, give up alcohol and spicy food.
Claims (4)
1. a kind of new opplication of polyzyme tablets, it is characterised in that：Described polyzyme tablets is in treatment nettle rash and other itching disease medicines
In application.
2. a kind of new opplication of polyzyme tablets as claimed in claim 1, it is characterised in that：Every contains 300 milligrams of pancreatin, stomach cardia
The polyzyme tablets one time that 13 milligrams of enzyme 6, three times a day.
3. the new opplication of polyzyme tablets as claimed in claim 2, it is characterised in that：It is within four days a course for the treatment of, is within seven days consolidation.
4. the new opplication of polyzyme tablets as claimed in claim 1, it is characterised in that：Described polyzyme tablets is treating stomach energy, wet
Heat, the application in hydrochloric acid in gastric juice medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710122430.4A CN106860860A (en) | 2017-03-03 | 2017-03-03 | The new opplication of polyzyme tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710122430.4A CN106860860A (en) | 2017-03-03 | 2017-03-03 | The new opplication of polyzyme tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106860860A true CN106860860A (en) | 2017-06-20 |
Family
ID=59169631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710122430.4A Pending CN106860860A (en) | 2017-03-03 | 2017-03-03 | The new opplication of polyzyme tablets |
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| Country | Link |
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| CN (1) | CN106860860A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1222453A (en) * | 1983-01-21 | 1987-06-02 | Gerald L. Bilton | Enzyme ointment |
| CN1562359A (en) * | 2004-04-02 | 2005-01-12 | 北京奥路特生物医药研发有限公司 | Capsules of multienzyme combination |
| CN102949712A (en) * | 2011-08-21 | 2013-03-06 | 李红彬 | Chinese and western composite medicine for treating neoplastic diseases |
| CN106063931A (en) * | 2016-07-25 | 2016-11-02 | 四川英奈德医疗科技有限公司 | A kind of for treating wound pruritus and promoting the compositions of wound healing |
| CN106215176A (en) * | 2016-08-22 | 2016-12-14 | 安徽瑞达健康产业投资有限公司 | A kind of efficiently antiinflammatory multienzyme compositions |
-
2017
- 2017-03-03 CN CN201710122430.4A patent/CN106860860A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1222453A (en) * | 1983-01-21 | 1987-06-02 | Gerald L. Bilton | Enzyme ointment |
| CN1562359A (en) * | 2004-04-02 | 2005-01-12 | 北京奥路特生物医药研发有限公司 | Capsules of multienzyme combination |
| CN102949712A (en) * | 2011-08-21 | 2013-03-06 | 李红彬 | Chinese and western composite medicine for treating neoplastic diseases |
| CN106063931A (en) * | 2016-07-25 | 2016-11-02 | 四川英奈德医疗科技有限公司 | A kind of for treating wound pruritus and promoting the compositions of wound healing |
| CN106215176A (en) * | 2016-08-22 | 2016-12-14 | 安徽瑞达健康产业投资有限公司 | A kind of efficiently antiinflammatory multienzyme compositions |
Non-Patent Citations (3)
| Title |
|---|
| 刘瑾冠等: ""谈多酶片的临床应用"", 《中国生化药物杂志》 * |
| 孙涛: "《家庭常用药物合理使用指南》", 31 October 2016, 吉林科学技术出版社 * |
| 胡学智等: ""蛋白酶生产和应用的进展"", 《工业微生物》 * |
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| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170620 |
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| RJ01 | Rejection of invention patent application after publication |