CN106860033A - Washing-free antibacterial is washed one's hands gel and preparation method thereof - Google Patents

Washing-free antibacterial is washed one's hands gel and preparation method thereof Download PDF

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Publication number
CN106860033A
CN106860033A CN201710087653.1A CN201710087653A CN106860033A CN 106860033 A CN106860033 A CN 106860033A CN 201710087653 A CN201710087653 A CN 201710087653A CN 106860033 A CN106860033 A CN 106860033A
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washing
mass parts
washed
hands
added
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CN201710087653.1A
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Chinese (zh)
Inventor
阮鹏
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Nanjing Pioneer Synergy Nanometer Technology Co Ltd
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Nanjing Pioneer Synergy Nanometer Technology Co Ltd
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Priority to CN201710087653.1A priority Critical patent/CN106860033A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02Acyclic compounds
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/042Gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48Thickener, Thickening system

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Washed one's hands gel and preparation method thereof the present invention relates to a kind of washing-free antibacterial including Nano-Zinc antiseptic.Washing-free antibacterial of the invention gel of washing one's hands has outstanding bactericidal effect and low-down skin irritation, can be widely applied to the antibacterial of skin and body surface in daily life, antibacterial, sterilization.

Description

Washing-free antibacterial is washed one's hands gel and preparation method thereof
Technical field
The invention belongs to sterile products technical field, and in particular to a kind of washing-free antibacterial is washed one's hands gel, and preparation method thereof.
Background technology
Antibacterial includes antibacterial, sterilizing, sterilized, mould proof, anti-corrosion.Bacterium is killed using chemically or physically method or is prevented thin The process of bacteria growing breeding is the general name of antibacterial.Antiseptic is can to make certain micro-organisms within a certain period of time(Bacterium, fungi, Saccharomycete, algae and virus etc.)Growth or breeding be maintained at necessary chemical substance below horizontal.
Antiseptic is broadly divided into organic antibacterial agent, inorganic antiseptic and natural antibacterial agent.Organic antibacterial agent anti-microbial property is high, Sterilization speed is fast, but to environment and human body is harmful and working life is short, poor heat resistance;Natural antibacterial agent antimicrobial efficiency is high, peace Atoxic, but processing difficulties, poor heat resistance.Inorganic antiseptic is because its effective antibacterial phase is long, the good, has a broad antifungal spectrum of heat resistance etc. Feature turns into the class antiseptic being most widely used.
In inorganic antiseptic, at most, purposes is most for the inorganic salts of metal ion or the inorganic antiseptic kind of complex compound Extensively, at most, wherein antibiotic property size is ordered as yield:Hg>Ag>Cd>Cu>Zn>Fe>Ni etc., but be with antibiotic property only Inadequate, also requiring that it can not be damaged to human body, the metal such as Hg, Cd, Pb also has antibacterial ability, but harmful. The security of metal ion is ordered as:Ag>Co>Ni>Al>Zn>Cu=Fe>Mn>Sn>Ba>Mg>Ca, so with regard to security and antibacterial Property the common result for considering, next to that Cu systems and Zn systems, therefore these three with inorganic compound as carrier with Ag ions preferably Inorganic antiseptic is obtained a wide range of applications.But, Cu ions carry color because of itself, can influence the expressive force of product;Silver Because its easy oxidation discoloration, it is expensive, easily reunite the problems such as, be restricted using scope.
Metallic zinc is the 1/1000 of argent due to the antibacterial ability of itself, causes most of research institutions and manufacturer All energy is concentrated in the modified research and development of Ag and Nano Silver to improve it as the performance of antiseptic, so as to have ignored zinc conduct The plurality of advantages of antiseptic, studies seldom it.In fact, Nano-Zinc antiseptic can overcome nano silver antimicrobials actually should Many defects in, such as easily oxidation, blackening, expensive, difficult dispersion, and possess significant antibacterial effect, significantly Extend antibacterial ageing, especially can relatively easily be scattered in corresponding product, such as plastics, textile fabric, slurry, Waterborne liquid, oil soluble liquid, greatly extend range of application.Therefore, research and development Nano-Zinc antiseptic can be greatly Meet social desirability.
Within past a very long time, sanitary washing is used as commonly using soap, perfumed soap in people's daily life Articles for use.Though soap, perfumed soap easily slide when in use with good dirt-removing power, meeting water and high temperature can soften and nature Consumption, soap, perfumed soap can make dry skin in alkalescence after cleaning, lack gloss, and soap, perfumed soap are sterilized in cleaning process Effect is limited, and is bound to be infected with dirt on hand and bacterium after use, produces secondary pollution, and washing-free antibacterial wash one's hands it is solidifying Glue have antibacterial, skin care, using and effect easy to clean etc..Recently as growth in the living standard, people's consumption idea Also change therewith, demand higher is it is also proposed to hygiene, gel substitutes conventional soap, perfume (or spice) so that washing-free antibacterial is washed one's hands Soap, as widely used hand-washing article, is applied to work, family and public arena.
At present on the market antibacterial wash one's hands gel major antibacterial composition with parachlorometaxylenol, gluconic acid chlorhexidine, Based on iodine class, alcohols, quaternary ammonium salt and its complex antimicrobials, these antiseptics be all easily caused to varying degrees the resistance to the action of a drug and Anaphylactoid generation, and there is the defects such as action time is short, bactericidal range is narrow.
The content of the invention
Washed one's hands the problems of gel to solve above-mentioned washing-free antibacterial in the prior art, the present invention proposes one kind to be included The washing-free antibacterial of Nano-Zinc antiseptic is washed one's hands gel and preparation method thereof, washing-free antibacterial of the invention wash one's hands gel have it is outstanding Bactericidal effect and low-down skin irritation, can be widely applied to skin and body surface in daily life antibacterial, it is antibacterial, Sterilization.
In an aspect, washed one's hands gel the present invention relates to a kind of washing-free antibacterial, be grouped by each group of following mass fraction Into:The mass parts of Nano-Zinc antiseptic 0.5 ~ 3, the mass parts of ethanol 20 ~ 65, the mass parts of thickener 0.1 ~ 5, the mass of emollient 0.1 ~ 5 Part, the mass parts of deionized water 10 ~ 90, the mass parts of essence 0 ~ 0.5.
In a preferred embodiment, the content of the essence is not zero.
Described thickener be preferably selected from hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, card ripple, One or more in xanthans, guar gum, Arabic gum and pectin.The Main Function of thickener is to make solution be in gel Shape, antiseptic is uniformly dispersed wherein, can be in skin surface stabilization quick release after use.
Described emollient is preferably selected from glycerine, dimethicone, aloe, vitamin E, propane diols, Sodium Hyaluronate With one or more in olive oil.Moisturizing and Main Function be in cleaning and sterilization process, keep skin it is smooth With it is moist.
In a preferred embodiment, described washing-free antibacterial gel of washing one's hands is grouped into by each group of following mass fraction: The mass parts of Nano-Zinc antiseptic 1, the mass parts of ethanol 55, the mass parts of hydroxyethyl cellulose 1, the mass parts of glycerine 0.5, deionized water 42 Mass parts, the mass parts of essence 0.03.
In another aspect, washed one's hands the present invention relates to the washing-free antibacterial preparation method of gel, comprised the following steps:
(1)The Nano-Zinc antiseptic of formula rate amount is added in reactor, the deionized water for being subsequently added 2/3 formula ratio is stirred Mix 3-10min;Preferably 4-6min;More preferably 5min;
(2)Speed of agitator is controlled for 180 ~ 200rpm, thickener is divided 1 ~ 3 time be slowly added into above-mentioned solution while stirring, The A liquid of clear homogeneous is obtained after being sufficiently stirred for;
(3)The water of surplus is added in another reactor, the emollient of formula ratio is then added under stirring, stirring is extremely It is well mixed;
(4)Under agitation toward by step(3)The ethanol of formula ratio is added in the mixed liquor of acquisition, stirring forms B to well mixed Liquid;
(5)B liquid is slowly added into A liquid under agitation, is continued stirring until well mixed;
(6)The essence of formula ratio is added dropwise under agitation, and continues stirring to well mixed, washing-free antibacterial is obtained after standing and is washed one's hands Gel.
Wherein, step(2)The bubble that produces is less when involved mixing speed is less than 180rpm, but mixing cycle compared with It is long;When mixing speed is more than 200rpm, mixing cycle is short, but can produce more bubble, mixes uneven.
Nano-Zinc antiseptic of the invention and preparation method thereof for example may refer to Chinese patent application CN 201510532442.5, entire contents are incorporated herein here by reference.
Specific embodiment
Embodiments of the invention will hereafter be conducted further description, wherein, each embodiment is only the exemplary present invention Implementation method, it is not intended to constitute limiting the scope of the invention.Those skilled in the art can according to explanation above with And following description of the embodiments makes various different improvement and deformation, it is without departing from spirit and substance of the present invention. Accordingly, the scope of the present invention is intended merely to be defined by every claim scope required for protection.
Embodiment 1
Washing-free antibacterial of the invention gel preparation course of washing one's hands is as follows:(1)1g Nano-Zinc antiseptics are added in reactor, with 60g deionized waters stirring 5min is added afterwards;(2)Speed of agitator is controlled for 180rpm, while stirring by 0.8g hydroxyethyl celluloses Divide 3 times and be slowly added into above-mentioned solution, the A liquid of clear homogeneous is obtained after being sufficiently stirred for;(3)30g water is added to another anti- In answering kettle, 2g glycerine is then added under stirring, stirring is to well mixed;(4)Under agitation toward by step(3)Obtain 50g ethanol is added in mixed liquor, stirring forms B liquid to well mixed;(5)B liquid is slowly added into A liquid under agitation, Continue stirring until well mixed;(6)0.01g essence is added dropwise under agitation, and continues stirring to well mixed, obtained after standing Washing-free antibacterial is washed one's hands gel.
Embodiment 2
Washing-free antibacterial of the invention gel preparation course of washing one's hands is as follows:(1)1g Nano-Zinc antiseptics are added in reactor, with 28g deionized waters stirring 5min is added afterwards;(2)Speed of agitator is controlled for 200rpm, while stirring by 1g hydroxyethyl celluloses point 2 It is secondary to be slowly added into above-mentioned solution, the A liquid of clear homogeneous is obtained after being sufficiently stirred for;(3)14g water is added to another reactor In, then adding 0.5g glycerine under stirring, stirring is to well mixed;(4)Under agitation toward by step(3)What is obtained is mixed Addition 55g ethanol in liquid is closed, stirring forms B liquid to well mixed;(5)B liquid is slowly added into A liquid under agitation, is held Continuous stirring is to well mixed;(6)0.03g essence is added dropwise under agitation, and continues stirring to well mixed, exempted from after standing Antibacterial is washed to wash one's hands gel.
Embodiment 3
Washing-free antibacterial of the invention gel preparation course of washing one's hands is as follows:(1)1g Nano-Zinc antiseptics are added in reactor, with 50g deionized waters stirring 5min is added afterwards;(2)Speed of agitator is controlled for 190rpm, while stirring by 0.5g hydroxyethyl celluloses It is slowly added into above-mentioned solution, the A liquid of clear homogeneous is obtained after being sufficiently stirred for;(3)25g water is added to another reactor In, then adding 1g glycerine under stirring, stirring is to well mixed;(4)Under agitation toward by step(3)The mixing of acquisition 60g ethanol is added in liquid, stirring forms B liquid to well mixed;(5)B liquid is slowly added into A liquid under agitation, is continued Stirring is to well mixed;(6)0.01g essence is added dropwise under agitation, and continues stirring to well mixed, obtained after standing disposable Antibacterial is washed one's hands gel.
Embodiment 4
Washing-free antibacterial of the invention gel preparation course of washing one's hands is as follows:(1)0.5g Nano-Zinc antiseptics are added in reactor, It is subsequently added 8g deionized waters stirring 3min;(2)Speed of agitator is controlled for 180rpm, while stirring by 0.1g hydroxyethyl celluloses It is slowly added into above-mentioned solution, the A liquid of clear homogeneous is obtained after being sufficiently stirred for;(3)4g water is added in another reactor, Then add 0.5g glycerine under stirring, stirring is to well mixed;(4)Under agitation toward by step(3)The mixing of acquisition 64g ethanol is added in liquid, stirring forms B liquid to well mixed;(5)B liquid is slowly added into A liquid under agitation, is continued Stirring is to well mixed;(6)0.01g essence is added dropwise under agitation, and continues stirring to well mixed, obtained after standing disposable Antibacterial is washed one's hands gel.
Embodiment 5
Washing-free antibacterial of the invention gel preparation course of washing one's hands is as follows:(1)3g Nano-Zinc antiseptics are added in reactor, with 60g deionized waters stirring 5min is added afterwards;(2)Control speed of agitator for 200rpm, while stirring delay 5g hydroxyethyl celluloses Slowly it is added in above-mentioned solution, the A liquid of clear homogeneous is obtained after being sufficiently stirred for;(3)30g water is added in another reactor, Then add 4.7g glycerine under stirring, stirring is to well mixed;(4)Under agitation toward by step(3)The mixing of acquisition 20g ethanol is added in liquid, stirring forms B liquid to well mixed;(5)B liquid is slowly added into A liquid under agitation, is continued Stirring is to well mixed;(6)0.5g essence is added dropwise under agitation, and continues stirring to well mixed, obtained after standing disposable Antibacterial is washed one's hands gel.

Claims (7)

1. a kind of washing-free antibacterial is washed one's hands gel, it is characterised in that be grouped into by each group of following mass fraction:Nano-Zinc antiseptic 0.5 ~ 3 mass parts, the mass parts of ethanol 20 ~ 65, the mass parts of thickener 0.1 ~ 5, the mass parts of emollient 0.1 ~ 5, deionized water 10 ~ 90 Mass parts, the mass parts of essence 0 ~ 0.5.
2. washing-free antibacterial according to claim 1 is washed one's hands gel, it is characterised in that:The content of essence is not zero.
3. washing-free antibacterial according to claim 1 and 2 is washed one's hands gel, it is characterised in that:Thickener is selected from hydroxy ethyl fiber One kind in element, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, card ripple, xanthans, guar gum, Arabic gum and pectin Or it is several.
4. the washing-free antibacterial according to any one of claims 1 to 3 is washed one's hands gel, it is characterised in that:Emollient be selected from glycerine, One or more in dimethicone, aloe, vitamin E, propane diols, Sodium Hyaluronate and olive oil.
5. washing-free antibacterial according to claim 1 is washed one's hands gel, it is characterised in that described washing-free antibacterial wash one's hands gel by The each group of following mass fraction is grouped into:The mass parts of Nano-Zinc antiseptic 1, the mass parts of ethanol 55, the mass of hydroxyethyl cellulose 1 Part, the mass parts of glycerine 0.5, the mass parts of deionized water 42, the mass parts of essence 0.03.
6. the washing-free antibacterial according to any one of claim 1 to 5 is washed one's hands the preparation method of gel, it is characterised in that including with Lower step:
(1)The Nano-Zinc antiseptic of formula rate amount is added in reactor, the deionized water for being subsequently added 2/3 formula ratio is stirred Mix 3-10min;
(2)Speed of agitator is controlled for 180 ~ 200rpm, thickener is divided 1 ~ 3 time be slowly added into above-mentioned solution while stirring, The A liquid of clear homogeneous is obtained after being sufficiently stirred for;
(3)The water of surplus is added in another reactor, the emollient of formula ratio is then added under stirring, stirring is extremely It is well mixed;
(4)Under agitation toward by step(3)The ethanol of formula ratio is added in the mixed liquor of acquisition, stirring forms B to well mixed Liquid;
(5)B liquid is slowly added into A liquid under agitation, is continued stirring until well mixed;
(6)The essence of formula ratio is added dropwise under agitation, and continues stirring to well mixed, washing-free antibacterial is obtained after standing and is washed one's hands Gel.
7. preparation method according to claim 6, it is characterised in that:Step(1)Mixing time be 4-6min, preferably 5min。
CN201710087653.1A 2017-02-17 2017-02-17 Washing-free antibacterial is washed one's hands gel and preparation method thereof Pending CN106860033A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108271807A (en) * 2018-02-05 2018-07-13 南京凯创协同纳米技术有限公司 Travelling antimicrobial spray
CN108888631A (en) * 2018-08-01 2018-11-27 西安惠普生物科技有限公司 A kind of preparation method of the antibacterial gel containing zinc
CN111617000A (en) * 2020-06-17 2020-09-04 广州欧盛化妆品有限公司 Lightyellow sophora root nano-silver washing-free disinfectant and preparation method thereof
CN112206178A (en) * 2020-10-26 2021-01-12 江苏华铭工贸有限公司 Alcohol gel and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104873432A (en) * 2015-05-28 2015-09-02 南阳市汇博生物技术有限公司 Hand-care disposable disinfection gel and preparation method thereof
CN105708718A (en) * 2016-04-13 2016-06-29 广州丹奇日用化工厂有限公司 Acne-removal cosmetic composition containing nano-zinc
CN105748309A (en) * 2016-05-04 2016-07-13 浙江焜之琳生物医药科技股份有限公司 No-clean antibacterial hand-washing solution and preparation method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104873432A (en) * 2015-05-28 2015-09-02 南阳市汇博生物技术有限公司 Hand-care disposable disinfection gel and preparation method thereof
CN105708718A (en) * 2016-04-13 2016-06-29 广州丹奇日用化工厂有限公司 Acne-removal cosmetic composition containing nano-zinc
CN105748309A (en) * 2016-05-04 2016-07-13 浙江焜之琳生物医药科技股份有限公司 No-clean antibacterial hand-washing solution and preparation method

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108271807A (en) * 2018-02-05 2018-07-13 南京凯创协同纳米技术有限公司 Travelling antimicrobial spray
CN108888631A (en) * 2018-08-01 2018-11-27 西安惠普生物科技有限公司 A kind of preparation method of the antibacterial gel containing zinc
CN108888631B (en) * 2018-08-01 2021-09-14 西安惠普生物科技有限公司 Preparation method of zinc-containing antibacterial gel
CN111617000A (en) * 2020-06-17 2020-09-04 广州欧盛化妆品有限公司 Lightyellow sophora root nano-silver washing-free disinfectant and preparation method thereof
CN112206178A (en) * 2020-10-26 2021-01-12 江苏华铭工贸有限公司 Alcohol gel and preparation method thereof

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