CN106860029B

CN106860029B - Physical antibacterial wet tissue

Info

Publication number: CN106860029B
Application number: CN201710085887.2A
Authority: CN
Inventors: 葛宏伟
Original assignee: SUZHOU BORAGE DAILY CHEMICAL CO Ltd
Current assignee: SUZHOU BORAGE DAILY CHEMICAL CO Ltd
Priority date: 2017-02-17
Filing date: 2017-02-17
Publication date: 2020-07-28
Anticipated expiration: 2037-02-17
Also published as: CN106860029A

Abstract

A physical antibacterial wet tissue comprises a wet tissue body and wet tissue liquid, wherein the wet tissue body is made of non-woven fabrics with an antimicrobial film or nano-particles with positive charges, the antimicrobial film or the nano-particles are formed by chemical bond combination, the wet tissue liquid is made of RO purified water, a surfactant, an emollient, a humectant, a skin conditioner and other additives, then ozone concentration of 0.1-1.0 mg/L is introduced into the wet tissue liquid, finally, the wet tissue liquid is added into the wet tissue body according to a certain weight ratio, and sealed packaging is carried out, so that the physical antibacterial wet tissue is formed.

Description

Physical antibacterial wet tissue

Technical Field

The invention relates to a physical antibacterial wet tissue, in particular to an infant hip-protecting wet tissue.

Background

In recent years, the application of wet tissues brings convenience to the life of people and gradually becomes a necessity in the life of people, so the annual output and consumption of the wet tissues are rapidly increased, and the application field of the wet tissues is continuously expanded, and the development requirements of corresponding products are higher and higher. At present, the variety of wet tissues is various, such as hand and mouth wet tissues, sanitary wet tissues, makeup removing wet tissues, skin cleaning wet tissues and the like, and with the continuous expansion of market scale, the national industrial policy encourages the development of the wet tissue industry to products with high technology and high added value, and improves the product competitiveness and market share, so the development of the wet tissue formula technology plays an important role.

The antiseptic for wet tissue is the topic of particular attention of consumers, most of the antiseptic reacts with certain components of cell walls after contacting with cell membranes, mainly with protein, destroys the protective structure of microbial cells or interferes with the metabolism of cells, and influences the normal growth order of cells, thereby achieving the purpose of antisepsis, and cations mainly influence the osmotic pressure to break, shrink and lose water of the cell membranes, thereby sterilizing. There are mainly 3 ways: 1) the protein of the microorganism is denatured or coagulated, a large amount of protein exists in the microorganism, and the protein can be denatured or coagulated by all factors which can destroy the three-dimensional configuration of the protein. 2) The enzyme system of the microorganism is interfered, the action of the intracellular enzyme of the microorganism is related to the active group of the enzyme, and all the substances which can change or destroy the function of the active group of the intracellular enzyme can inhibit the activity of the enzyme of the microorganism. 3) The permeability of cell membranes is changed, and after the cationic surfactant and phenols act on microorganisms, the structure of the cell membranes can be changed, the normal functions of the cells are interfered, and the cells die.

At present, the antiseptic used in the wet tissue industry in China is various, most of the antiseptic is chemical antiseptic, and the chemical antiseptic is popular with wet tissue manufacturers due to simple structure, clear action mechanism, stable property, wide antimicrobial spectrum and low price. In fact, some of the users of antiseptics have found an unexpected phenomenon that the same antiseptic is added in an amount several times as much as several years ago, and the spoilage of the product still occurs, and most of them are caused by the decrease in the sensitivity of the flora to the antiseptic due to the long-term continuous use of a certain kind of antiseptic(s), which is called the resistance of the microorganism to the antiseptic, and in such a case, the skin of the consumer is easily allergic and irritated. However, with the development of science, the continuous improvement of safety awareness of consumers and the growing concern on health, people gradually find that chemical preservatives in wet tissues can generate adverse effects on human bodies, so that the requirements for using the wet tissue preservatives are higher and higher, and the wet tissue industry is prompted to find an alternative way for the chemical preservatives to reduce the damage to the skin of the consumers. The traditional chemical preservative can not meet the concept of 'green' and 'health' pursued by people, and the appearance of natural preservatives and no preservatives just make up for the gap, so that the research and the use of chemical preservative substitutes without stimulation and with high safety become a trend in the daily chemical industry at present.

CN103566371A discloses an antimicrobial method of using a silicone diquaternary ammonium salt of the following formula (I) (R1R2R3N + X-) -R5- (R1R2R3N + X-) (I) wherein each R1 is independently C8-18 alkyl, C8-18 alkenyl or C8-18 alkynyl, each R2 and R3 are independently methyl or ethyl, R5 is C3-10 alkylene substituted at β -or more distal by tri (C1-3 alkoxy) siloxy or tri (C1-3 alkoxy) silyl-C1-6 alkoxy, and each X-is independently a pharmaceutically acceptable counter anion, applied on the surface of an object requiring antimicrobial to form an antimicrobial film.

CN101716359A discloses a sterilization and disinfection material, which is characterized in that a compound with functional groups for capturing bacteria and viruses is fixed on the surface of a non-woven fabric by a chemical bond through a grafting process, and the compound comprises one or more of quaternary ammonium salt, a sulfur-containing compound and a sulfonic acid-containing compound. The sterilization and disinfection material can be widely applied to sterilization and disinfection products, such as wet towels, cotton balls, disinfection wrapping cloth and the like.

In order to solve the problems that in the prior art, a wet tissue is easy to precipitate a preservative and has irritation, the invention provides a physical antibacterial wet tissue which has the antiseptic and antibacterial capabilities because the antibacterial film or particles with positive charges and the microbial cell membrane with negative charges generate electrostatic force to break the microbial cell membrane or change the form of the microbial cell membrane, so that microorganisms die.

Disclosure of Invention

The invention provides a physical antibacterial wet tissue which comprises a wet tissue body and wet tissue liquid, wherein the wet tissue body is made of non-woven fabrics with an antimicrobial film or nano particles with positive charges, the antimicrobial film or nano particles are formed by chemical bond combination, the wet tissue liquid is made of RO purified water, a surfactant, an emollient, a humectant, a skin conditioner and other additives, then ozone concentration of 0.1-1.0 mg/L is introduced into the wet tissue liquid, and finally the wet tissue liquid is added into the wet tissue body according to a certain weight ratio and sealed and packaged to form the physical antibacterial wet tissue.

The physical antibacterial wet tissue consists of a wet tissue body and a wet tissue liquid, wherein the wet tissue body is a non-woven fabric bonded with a high-molecular quaternary ammonium salt; the wet tissue liquid consists of the following components in percentage by weight:

RO purified water 50-92%

0.1 to 10 percent of surfactant

0.1-10% of emollient

Humectant 5-20%

Skin conditioner 0.1-5%

0.01 to 8 percent of other additives,

the sum of the contents of all the components is 100 percent.

The preparation method of the wet tissue body comprises the following steps:

(1) bamboo pulp fiber with the length of 35-50mm and the diameter of 0.05-0.1mm is used as a raw material, and a fiber net is formed through the procedures of weighing, cotton mixing, opening, mechanical carding and disordered lapping;

(2) respectively puncturing the front and back surfaces of the fiber net by 4-10 water needles formed by high-pressure micro water flow to completely wet the fiber net so as to tangle and reinforce the fiber net; the micro water flow is an aqueous solution of organosilicon biquaternary ammonium salt A or organosilicon biquaternary ammonium salt B with the mass fraction of 0.5-0.7%;

(3) the fiber net is placed at the temperature of 120-128 ℃ for crosslinking and drying for 5-8 min;

(4) cutting and sterilizing at high temperature to obtain a non-woven fabric wet tissue body with the thickness of 3-5 mm;

wherein the organosilicon biquaternary ammonium salt A is 2-triethoxysilylpropanyloxy-1-N, N-dimethyloleoyl-3-octadecyl dimethyl ammonium propane dichloride:

the organosilicon biquaternary ammonium salt B is 2-triethoxysilylpropanyloxy-1-N, N-dimethyl oleoyl-3-dodecyl dimethyl ammonium propane dichloride:

the surfactant is nonionic surfactant, and is selected from one or more of polyglycerol-2 oleate, sorbitan stearate, sorbitol laurate, dimethicone copolyol, cetyl-octadecyl glucose ester, polysorbate, and sorbitan fatty acid ester;

the emollient is a component with skin moistening effect, and is selected from one or more of lecithin, hydrogenated lecithin, shea butter, dioctyl carbonate, jojoba oil, dimethyl silicone oil, caprylic/capric triglyceride, cetyl isooctanoate, white mineral oil, glyceryl monostearate, and α -bisabolol;

the humectant is a component with moisturizing effect and is selected from polyalcohol, betaine, panthenol and allantoin, wherein the polyalcohol is one or more of glycerol, propylene glycol, 1, 3-butanediol, dipropylene glycol, caprylyl glycol and 1, 2-pentanediol;

the skin conditioner is one or more of ceramide, coenzyme Q10, tocopherol acetate, resveratrol and astaxanthin;

the other additive is one or more of antioxidant, chelating agent, and pH regulator, and is selected from one or more of butylated hydroxytoluene, EDTA-2Na, EDTA-4Na, arginine, citric acid, and sodium citrate.

The invention also provides a preparation method of the wet tissue liquid, which is characterized in that the wet tissue liquid is transparent and stable skin care emulsion, and the method comprises the following steps:

(1) mixing 0.1-10% of surfactant and 0.1-10% of emollient, heating to 50-80 deg.C, and rapidly stirring at the temperature for 5-20min to obtain transparent solution A.

(2) Mixing RO purified water 50-92%, humectant 5-20% and other additives 0.01-8%, heating to 60-90 deg.C, and stirring to obtain transparent solution B.

(3) Slowly adding the solution B into the solution A under high-speed stirring until a transparent solution C is obtained,

(4) cooling the solution C to below 45 deg.C, adding skin conditioner 0.1-5%, stirring, and making into transparent solution D.

(5) And (3) introducing ozone into the solution D, wherein the concentration of the ozone is kept within the range of 0.1-1.0 mg/L, and preferably the concentration of the ozone is kept within the range of 0.1-0.5 mg/L, so as to obtain the wet tissue liquid E.

The invention further provides a preparation method of the physical antibacterial wet tissue, which is characterized in that the wet tissue liquid E and the wet tissue body cut into proper size are added according to the weight ratio of 1.5: 1-4: 1, and then the physical antibacterial wet tissue is obtained after sealing and packaging.

The physical antibacterial wet tissue has the function of killing or inhibiting microorganisms, is safe to human bodies, and can avoid drug resistance caused by chemical antibacterial preservatives. The organosilicon quaternary ammonium salt forms an antimicrobial surface film with excellent durability by combining covalent bond and electrostatic adsorption.

One is the positive center [ N ] in the molecule⁺]The fiber is attracted by the fiber surface with negative charge, which is electrostatic bonding, and intermolecular dehydration condensation is carried out at the same time, so that a covering film is formed on the fiber surface, and the bonding strength is weak and the lasting coverage is weak.

Secondly, under the condition of more than 120 ℃, alcohol groups generated by the hydrolysis of the molecules are combined with-OH on the surface of the fiber, and intermolecular dehydration condensation is carried out simultaneously, so that the molecules are firmly combined on the surface of the fiber by covalent bonds.

Compared with the traditional wet tissue, the wet tissue has the following advantages:

1. the traditional wet tissue adopts adhesive to fix the antibacterial agent in the non-woven fabric, and the wet tissue is combined in the non-woven fabric through stable chemical bonds;

2. the traditional wet tissue has a certain amount of separated preservatives, and the wet tissue is a product with no separated preservatives;

3. the traditional wet tissue has the anticorrosion function that the normal growth order of cells is influenced by destroying the protection structure of microbial cells or interfering the metabolism of the cells, so that the purpose of anticorrosion is achieved. The antiseptic function of the wet tissue is that the antimicrobial film or the nano particles with positive charges and the antimicrobial film with negative charges break and die the microbial cell membrane under the action of electrostatic force, thereby achieving the antiseptic and antibacterial functions.

4. The chemical antiseptic antibacterial wet tissue is applied to the surface of a human body for a long time, and symptoms such as human body allergy and the like can be caused, such as dermatitis, speckles and even DNA damage can be caused by excessive use. In addition, during production, mutation bacteria or tolerant bacteria are easy to breed, unpredictable safety risk problems are increased for companies, and the application of the wet tissue completely avoids the adverse factors.

5. The antibacterial effect of the wet tissue exceeds that of a common chemical antiseptic antibacterial agent, the excellent antibacterial effect can be achieved only by using a small amount, the wet tissue is extremely mild and non-irritant to use, and can not generate drug resistance, and the wet tissue can be used for infant hip-protecting wet tissues, infant hand and mouth wet tissues, skin-cleaning wet tissues, sanitary wet tissues and the like.

Detailed Description

Preparation example 1:

1) reacting octadecyl dimethyl tertiary amine with epoxy chloropropane and hydrochloric acid:

dry hydrogen chloride gas was introduced into an anhydrous ether solution of octadecyl dimethyl tertiary amine to produce a white precipitate. Then using water as a solvent, placing a certain amount of epichlorohydrin in a dropping funnel, starting slow dropwise adding, completing dropwise adding within 35min, uniformly stirring at room temperature, reacting at 80 ℃ for 12h, determining a reaction end point by titrating the content of the quaternary ammonium salt of the epichlorohydrin, after the reaction is completed, rotationally evaporating at room temperature to remove the solvent to obtain a light yellow pasty residue, recrystallizing the pasty residue with acetone, performing vacuum filtration after crystals are separated out, repeating the steps for a plurality of times, and finally obtaining a white powder single-season ammonium salt product, namely an intermediate product N- (3-chloro-2-hydroxypropyl) -N, N-dimethyl octadecyl ammonium chloride.

2) The reaction process is as follows: heating methyl oleate to 100 ℃ under the protection of nitrogen, adding a catalyst, gradually adding dimethylamine for reacting for 6.5h, then carrying out reduced pressure distillation and vacuum drying to obtain the dimethyl oleoyl tertiary amine intermediate. Wherein the catalyst is 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (EDC) and (dimethylamino) carbenium Hexafluorophosphate (HATU) in a molar ratio of 1: 1.

3) Reaction: microwave-assisted synthesis is adopted, continuous reflux reaction is carried out for 7.5h at 110 ℃, low-temperature standing is carried out for 48h after the reaction is finished, and finally acetone is used for recrystallization.

4) III reaction with gamma-chloropropyltriethoxysilane:

heating to 50 ℃ under the condition of stirring reflux, reacting for 12h, removing residues by reduced pressure distillation, and then drying for 10h at 50 ℃ in vacuum to obtain the organosilicon biquaternary ammonium salt: 2-triethoxysilylpropanyloxy-1-N, N-dimethyloleoyl-3-octadecyldimethylammonium propane dichloride (short for organosilicon biquaternary ammonium salt A), the yield was 96.5%.

Preparation example 2:

same as in preparation example 1, except that: in the step 1), the anhydrous ether solution of dodecyl dimethyl tertiary amine is used, and finally 2-triethoxysilylpropanyloxy-1-N, N-dimethyloleoyl-3-dodecyl dimethyl ammonium propane dichloride (abbreviation: organosilicon diquaternary ammonium salt B) in a yield of 98.5%.

Example 1

The preparation method of the wet tissue body comprises the following steps:

(1) bamboo pulp fiber with the length of 40mm and the diameter of 0.08mm is used as a raw material, and is subjected to the procedures of weighing, cotton mixing, opening, mechanical carding and disordered lapping to form a fiber net;

(2) the front and back sides of the fiber net are respectively punctured by 10 water needles formed by high-pressure micro water flow, so that the fiber net is completely wetted through, and the fiber net is tangled and reinforced; the micro water flow is an aqueous solution of organosilicon biquaternary ammonium salt A with the mass fraction of 0.5%;

(3) then crosslinking and drying for 8min at the temperature of 120 ℃;

(4) cutting and sterilizing at high temperature to obtain a non-woven fabric wet tissue body with the thickness of 5 mm;

in the preparation process of the wet tissue liquid E, the solution A is selected from polysorbate-600.35 g, polyglycerol-2 oleate 0.1g, glycerol monostearate 0.1g and white mineral oil 0.1 g. The solution B is prepared from 9.7g of glycerol, 8g of propylene glycol, 0.05g of caprylyl glycol, 0.5g of sodium citrate, 0.5g of arginine, 0.5g of allantoin and 80g of RO purified water. The skin conditioner is water soluble ceramide 0.1 g.

The method specifically comprises the following steps:

1) polysorbate-600.35 g, polyglycerol-2 oleate 0.1g, glycerol monostearate 0.1g, and white mineral oil 0.1g were mixed and heated to 60 ℃ and rapidly stirred at that temperature for 15min to obtain a transparent solution A.

2) Mixing 9.7g of glycerol, 8g of propylene glycol, 0.05g of caprylyl glycol, 0.5g of sodium citrate, 0.5g of arginine, 0.5g of allantoin and 80g of RO purified water, heating to 70 ℃, and uniformly stirring until a transparent solution B is obtained.

3) The solution B was slowly added to the solution A with high speed stirring until a clear solution C was obtained.

4) And cooling the solution C to 40 ℃, adding 0.1g of water-soluble ceramide, uniformly stirring, and preparing a transparent solution D.

5) And (4) introducing ozone into the solution D, wherein the concentration of the ozone is kept at 0.3 mg/L, thus obtaining the wet tissue liquid E.

And adding the wet tissue liquid E and the wet tissue body according to the weight ratio of 4: 1, and then sealing and packaging to obtain the physical antibacterial wet tissue.

Example 2

The wet wipe body, the wet wipe liquid E, and the physical antibiotic wet wipe were prepared in the same manner as in example 1, except that the silicone diquaternary ammonium salt a was replaced with the silicone diquaternary ammonium salt B prepared in preparation example 2.

Example 3

The wet wipe body, the wet wipe liquid E and the physical antibacterial wet wipe were prepared in the same manner as in example 1, except that the mass fraction of the silicone diquaternary ammonium salt a was replaced with 0.7%.

Example 4

The wet wipe body, the wet wipe liquid E and the physical antibacterial wet wipe were prepared in the same manner as in example 1, except that the mass fraction of the silicone diquaternary ammonium salt a was replaced with 0.6%.

Example 5

The preparation methods of the wet tissue body, the wet tissue liquid E and the physical antibacterial wet tissue are the same as those in the embodiment 2, except that the solution A is composed of 5g of sorbitan monostearate, 5g of dimethicone copolyol, 5g of cetyl isooctanoate and 5g of lecithin; the solution B is prepared from 3g of dipropylene glycol, 0.5g of caprylyl glycol, 1.5g of glycerol, 5g of EDTA-2Na, 3g of citric acid and 62g of deionized water; the skin conditioner is astaxanthin 5 g.

Example 6

The wet wipe body, wet wipe liquid E, and physical antimicrobial wet wipes were prepared in the same manner as in example 2, except that the ozone concentration was maintained at 1.0 mg/L.

Example 7

The wet wipe body, the wet wipe liquid E, and the physical antibiotic wet wipe were prepared in the same manner as in example 1, except that the wet wipe liquid E and the wet wipe body were added in a ratio of 1.5: 1 by weight.

Comparative example 1

The wet wipe body, the wet wipe liquid E and the physical antibacterial wet wipe were prepared in the same manner as in example 1, except that the mass fraction of the silicone diquaternary ammonium salt a was replaced with 0.3%.

Comparative example 2

The wet wipe body, wet wipe liquid E, and physical antimicrobial wet wipe were prepared in the same manner as in example 1, except that the silicone bis-quaternary ammonium salt a was replaced with dimethyl diallyl ammonium salt.

Comparative example 3

The wet wipe body, wet wipe liquid E, and physical antimicrobial wet wipe were prepared in the same manner as in example 1, except that the silicone bis-quaternary ammonium salt a was replaced with N-methacryloyloxyethyl-N, N-dimethylammonium- α -N-methylcarboxylbetaine.

Comparative example 4

The wet wipe body, wet wipe liquid E, and physical antimicrobial wet wipe were prepared in the same manner as in example 1, except that the silicone bis-quaternary ammonium salt a was replaced with oleamide ethyl dimethyl aminopropyl methyl dimethoxy silane quaternary ammonium salt.

Comparative example 5

The wet wipe body, wet wipe liquid E, and physical antimicrobial wet wipe were prepared in the same manner as in example 1, except that the silicone diquaternary ammonium salt a was replaced with 2-triethoxysilylpropanyloxy-1-octadecenyl-3-octadecyldimethylammonium propane dichloride.

Comparative example 6

The wet wipe body, wet wipe liquid E, and physical antimicrobial wet wipe were prepared in the same manner as in example 1, except that the silicone diquaternary ammonium salt a was replaced with 2-triethoxysilylpropanyloxy-1-octenyl-3-octadecyldimethylammonium propane dichloride.

Comparative example 7

The wet wipe body, wet wipe liquid E, and physical antimicrobial wet wipe were prepared in the same manner as in example 1, except that the silicone bis-quaternary ammonium salt a was replaced with 2-triethoxysilylpropanyloxy-1-dodecenyl-3-octadecyldimethylammonium propane dichloride.

The technical effects are as follows:

1. bacteriostatic effect

The bacteriostatic rates of the wet tissues in the examples and the comparative examples were tested according to the evaluation standards in appendix C of GB15979-2002 of hygienic standards for disposable sanitary articles, and the test results are shown in Table 1:

TABLE 1 bacteriostatic effect of Wet wipes

As can be seen from the data in table 1, the wet towel product of the present invention has more excellent antibacterial properties than the wet towel of the comparative example.

2. Softness and smoothness

The wet wipes of the examples and comparative examples were evaluated for soft and smooth performance at 10 points using a 5-person evaluation group and the results are shown in Table 2:

TABLE 2 Soft and smooth Wet wipes

As can be seen from the data in table 2, the wet wipe product of the present invention has more excellent softness and slip properties than the wet wipes of the comparative examples.

3. Irritation property

The skin irritation test was performed on wet wipes according to the one-time complete skin irritation test in "disinfection specifications", and the test results are shown in table 3:

TABLE 3 irritation of Wet wipes

Grading standard:

erythema formation: 0 is absent, 1 is barely visible, 2 is obvious, 3 is severe, 4 is purplish red erythema with eschar;

edema formation: 0 is absent, 1 is barely visible, 2 is a skin bulge, well defined, 3 is an edema bulge of about 1mm, and 4 is an edema bulge exceeding 1 mm.

As can be seen from the data in Table 3, the wet wipe products of the present invention are less irritating than the wet wipes of the comparative examples.

4. Comfort level

The wet wipes of the above examples and comparative examples were administered to infants with red buttocks for 10 days, and the effects after use are shown in table 4:

TABLE 4 Wet wipes for infants at the red buttocks

Examples	Patient mild reduction (%)
		Example 1	90
Example 2	85
		Example 3	86
Example 4	90
		Example 5	88
Example 6	91
		Example 7	89
Comparative example 1	40
		Comparative example 2	36
Comparative example 3	42
		Comparative example 4	50
Comparative example 5	58
		Comparative example 6	52
Comparative example 7	54

As can be seen from the data in Table 4, the physical antibiotic disinfectant wet wipes for buttocks of red buttocks of the infant according to the present invention are significantly improved in patients and suitable for popularization and application, compared with the wet wipes in the comparative examples.

Claims

1. A physical antibacterial wet tissue comprises a wet tissue body and a wet tissue liquid, wherein the wet tissue body is a non-woven fabric bonded with a high-molecular quaternary ammonium salt; the wet tissue liquid consists of the following components in percentage by weight:

RO purified water 50-92%

0.1 to 10 percent of surfactant

0.1-10% of emollient

Humectant 5-20%

Skin conditioner 0.1-5%

0.01 to 8 percent of other additives,

the sum of the contents of all the components is 100 percent;

the preparation method of the wet tissue body comprises the following steps:

(3) then crosslinking and drying at the temperature of 120-128 ℃ for 5-8 min;

wherein the organosilicon biquaternary ammonium salt A is 2-triethoxysilylpropanyloxy-1-N, N-dimethyloleoyl-3-octadecyl dimethylammonium propane dichloride shown in formula 1:

the organosilicon biquaternary ammonium salt B is 2-triethoxysilylpropanyloxy-1-N, N-dimethyloleoyl-3-dodecyl dimethyl ammonium propane dichloride shown in a formula 2:

2. the physical antiseptic wet wipe as set forth in claim 1, wherein the surfactant is a nonionic surfactant selected from one or more of polyglycerol-2 oleate, sorbitan laurate, dimethicone copolyol, cetearyl glucose ester, polysorbate, and sorbitan fatty acid ester.

3. The physical antibacterial wet wipe as set forth in claim 1, wherein the emollient is an ingredient having skin moisturizing effect and is selected from one or a mixture of more than one of lecithin, hydrogenated lecithin, shea butter, dioctyl carbonate, jojoba oil, dimethicone, caprylic/capric triglyceride, cetyl isooctanoate, white mineral oil, glyceryl monostearate, and α -bisabolol.

4. The physical antibacterial wet towel of claim 1, wherein the humectant is a component with moisturizing effect and is selected from polyhydric alcohol, betaine, panthenol and allantoin, and the polyhydric alcohol is one or more of glycerol, propylene glycol, 1, 3-butanediol, dipropylene glycol, caprylyl glycol and 1, 2-pentanediol.

5. The physical antiseptic wet wipe of claim 1, wherein the skin conditioning agent is one or more of ceramide, coenzyme Q10, tocopherol acetate, resveratrol, astaxanthin.

6. The physical antiseptic wet wipe as set forth in claim 1, wherein the other additive is one or a mixture of more than one of an antioxidant, a chelating agent, and a pH adjusting agent.

7. The physical antiseptic wet wipe as set forth in claim 1 or 6, wherein the other additive is one or a mixture of more than one selected from butylated hydroxytoluene, EDTA-2Na, EDTA-4Na, arginine, citric acid, and sodium citrate.

8. The physical antiseptic wet wipe of claim 2, wherein the sorbitan fatty acid ester is sorbitan stearate.

9. The method of making a physical antiseptic wet wipe as set forth in any one of claims 1-8 wherein: the preparation method of the wet tissue body comprises the following steps:

(3) then crosslinking and drying at the temperature of 120-128 ℃ for 5-8 min;

the wet tissue liquid is transparent and stable skin care emulsion, and the preparation method comprises the following steps:

(1) mixing 0.1-10% of surfactant and 0.1-10% of emollient, heating to 50-80 deg.C, and rapidly stirring at the temperature for 5-20min to obtain transparent solution A;

(2) mixing RO purified water 50-92%, humectant 5-20% and other additives 0.01-8%, heating to 60-90 deg.C, and stirring to obtain transparent solution B;

(3) slowly adding the solution B into the solution A under high-speed stirring until a transparent solution C is obtained;

(4) cooling the solution C to below 45 deg.C, adding skin conditioner 0.1-5%, stirring well and making into transparent solution D;

(5) introducing ozone into the solution D, wherein the concentration of the ozone is kept within the range of 0.1-1.0 mg/L, and thus obtaining wet tissue liquid E;

finally, adding the wet tissue liquid E and the wet tissue body cut into a proper size according to the weight ratio of 1.5: 1-4: 1, and then sealing and packaging to obtain the physical antibacterial wet tissue.

10. The method of claim 9, wherein the ozone concentration is in the range of 0.1-0.5 mg/L.

11. The method of claim 9, wherein the wet towel liquid E is added to the wet towel body cut to a suitable size in a ratio of 2: 1 to 3: 1 by weight.