CN106772165A - The determination method and device of amide proton transfer effect - Google Patents
The determination method and device of amide proton transfer effect Download PDFInfo
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- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
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- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
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Abstract
The present invention is applied to software field, there is provided a kind of determination method and device of amide proton transfer effect.Methods described includes：Image is read, and obtains the original Z spectrums of the pixel of described image；It is fitted the direct saturation effect of water and fitting magnetization transfer effect respectively using Lorentzian；Amide proton transfer effect is determined according to the original Z spectrums and the direct saturation effect of water of fitting and the magnetization transfer effect of fitting.By the above method so that amide proton transfer effect quantifies more reliable.
Description
Technical field
The embodiment of the present invention belongs to software field, more particularly to a kind of amide proton transfer effect determination method and dress
Put.
Background technology
Amide proton transfer imaging is a kind of novel magnetic resonance molecular image technology, and it utilizes radio frequency saturation pulse, saturation
Hydrogen Proton in amino, number of ways Chemical Exchange is carried out by with the Hydrogen Proton in hydrone so that the reduction of moisture subsignal,
By detecting the change of water signal, the situation of amino can be gone out with indirect detection.Amide proton transfer imaging was suggested from 2003,
Get the attention.As correlation technique is developed rapidly, current amide proton transfer imaging has been applied to numerous areas, than
Such as lesion detection, ishemic stroke detection, show the great potential in terms of clinical practice.
Amide proton transfer effect is obtained by analyzing Z spectrums, and Z spectrums are normalized water signals on saturation frequency
Spectrogram.Amide proton is+3.5ppm relative to the chemical shift of hydrone, due to amide proton and the hydrogen matter in hydrone of saturation
There is exchange in son, so at+3.5ppm, water signal has obvious reduction, and the size of water signal fall is then amino matter
The height of sub- transfer effect.Under normal circumstances, there are various disturbing factors, such as the direct saturation effect of water, magnetization transfer in Z spectrums
Effect and Overhauser effect etc..Amide proton transfer effect is isolated exactly, it would be desirable to be able to effectively eliminate the dry of other factors
Disturb.The conventional method for quantifying amide proton transfer effect now is non-symmetry analysis, and the method assumes the direct saturation effect of water
Should be symmetrical with magnetization transfer effect (0ppm) at the resonant frequency of water, using Z spectrums to lateral areas as reference value, subtract+
Value at 3.5ppm, then be amide proton transfer effect.
Because asymmetry analytic approach assumes that the direct saturation effect of water and magnetization transfer effect are symmetrical, and this is often
Not to.Particularly in the magnetic field of Clinical practice, the resonant frequency of amide proton closely hydrone, this may result in
The direct saturation effect of water has flooded amide proton transfer effect.In addition to the direct saturation effect of water, in imaging in vivo, magnetization transfer
Effect is also not symmetrical.In addition asymmetry analytic approach also have ignored Overhauser effect, its chemistry relative to hydrone
Displacement is near -3.5ppm, and the chemical shift is the offside of frequency (+3.5ppm) where amide proton.Therefore, in routine
In asymmetry analysis method, Overhauser effect will influence the quantization of amide proton transfer effect, so as to cause quantitative analysis ammonia
The accuracy of the sub- transfer effect of matrix is relatively low.
The content of the invention
The embodiment of the invention provides a kind of determination method and device of amide proton transfer effect, it is intended to solve existing
The relatively low problem of the accuracy of method quantitative analysis amide proton transfer effect.
The first aspect of the embodiment of the present invention, there is provided a kind of determination method of amide proton transfer effect, methods described
Including：
Image is read, and obtains the original Z spectrums of the pixel of described image；
It is fitted the direct saturation effect of water and fitting magnetization transfer effect respectively using Lorentzian；
Amino matter is determined according to the original Z spectrums and the direct saturation effect of water of fitting and the magnetization transfer effect of fitting
Sub- transfer effect.
The second aspect of the embodiment of the present invention, there is provided a kind of determining device of amide proton transfer effect, described device
Including：
Image fetching unit, for reading image, and obtains the original Z spectrums of the pixel of described image；
Interference fitting unit, for being fitted the direct saturation effect of water and fitting magnetization transfer respectively using Lorentzian
Effect；
Amide proton transfer effect determining unit, for the direct saturation effect of water according to the original Z spectrums and fitting
Magnetization transfer effect with fitting determines amide proton transfer effect.
In embodiments of the present invention, due to by Lorentzian fit Z compose in account for governing effect water it is direct
Saturation effect and magnetization transfer effect, therefore, it can effectively to solve both factors to do amide proton transfer effect calculating
Disturb, so that the quantization of amide proton transfer effect is more reliable.
Brief description of the drawings
Fig. 1 is a kind of flow chart of the determination method of amide proton transfer effect that first embodiment of the invention is provided；
Fig. 2 is the B0 schematic diagram of correction of a kind of original Z spectrums that first embodiment of the invention is provided；
Fig. 3 is the magnetic of a kind of fitting Z spectrums, the direct saturation effect of water of fitting and fitting that first embodiment of the invention is provided
Change the schematic diagram of transfer effect；
Fig. 4 is that the original Z spectrums after a kind of normalization that first embodiment of the invention is provided and upset are composed with the fitting Z
The schematic diagram of the difference at+3.5ppm；
Fig. 5 is a kind of structured flowchart of the determining device of amide proton transfer effect that second embodiment of the invention is provided.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
In the embodiment of the present invention, image is read, and obtains the original Z of the pixel of described image and composed, using Lorentzian
The fitting direct saturation effect of water and fitting magnetization transfer effect, directly satisfy according to the original Z spectrums and the water being fitted respectively
Magnetization transfer effect with effect and fitting determines amide proton transfer effect.
In order to illustrate technical solutions according to the invention, illustrated below by specific embodiment.
Embodiment one：
Fig. 1 shows a kind of flow of the determination method of amide proton transfer effect that first embodiment of the invention is provided
Figure, the embodiment of the present invention can be programmed in the software environments such as MATLAB, and details are as follows：
Step S11, reads image, and obtain the original Z spectrums of the pixel of described image.
Because image has multiple pixels (pixel), therefore, the original Z spectrums of a certain pixel in image can be first obtained,
After step S11~step S13 is performed, recycling performs above-mentioned steps, the original Z spectrums of all pixels in obtaining image.
Wherein, the original Z spectrums of pixel are the Z spectrums of unprocessed mistake.
Alternatively, after the step S11, including：
The minimum point that the original Z of the pixel is composed is moved on at centre frequency 0ppm, to realize the main magnetic of magnetic resonance system
The correction of field.Wherein, the main field of magnetic resonance system is also referred to as B0.As shown in Fig. 2 using saturation signal obtain image in certain
The original Z spectrums of one pixel, after correction B0 so that the corresponding value of Z spectrums at the follow-up+3.5ppm places for determining is more accurate, so that
Improve the accuracy of the amide proton transfer effect for determining.
Step S12, the direct saturation effect of water and fitting magnetization transfer effect are fitted using Lorentzian respectively.
Lorentz curve can be very good to be fitted the saturated characteristic of relaxation time and the close tissue of water, it is possible to use Lip river
Human relations hereby curve come be fitted Z spectrum in each different chemical exchange process.The principal element of interference Z spectrums is imitated for the direct saturation of water
, by Lorentz fit method, both disturbing factors should be extracted from Z spectrums with magnetization transfer effect, be easy to follow-up energy
Enough more accurately determine amide proton transfer effect.
Step S13, the direct saturation effect of water according to the original Z spectrums and fitting is true with the magnetization transfer effect of fitting
Determine amide proton transfer effect.
Due to the disturbing factor that the direct saturation effect of water and magnetization transfer effect are original Z spectrums, therefore, from original Z spectrums
Filtering out the direct saturation effect of water and magnetization transfer effect can obtain accurate amide proton transfer effect.For example, directly filtering
Direct saturation effect component corresponding with magnetization transfer effect is removed water, certainly, speed is filtered in order to improve, can also filter part water
The direct corresponding component of saturation effect component corresponding with part magnetization transfer effect is filtered, but need to ensure that remaining water is directly satisfied
Component corresponding with effect component corresponding with magnetization transfer effect can not disturb original Z to compose.
Alternatively, when the direct saturation effect of water is directly filtered with the magnetization corresponding component of transfer effect, the step S13
Specifically include：
The sum of the magnetization transfer effect of A1, the direct saturation effect of water for determining fitting and fitting, as fitting Z spectrums；
A2, using the difference of the original Z spectrum and fitting Z spectrums as amide proton transfer effect.
Specifically, the direct saturation effect of water being fitted is added with the magnetization transfer effect of fitting, is shown below：
L (A, Lw, Δ ω)=A/ [1+4 (Δ ω/Lw)2]；
APT (Δ ω)=[1- (LWater+LMT)]-Z；
Wherein, A is amplitude, and Lw is that frequency spectrum is wide, and Δ ω is the relative displacement of the resonant frequency relative to water, and Z represents original Z
Spectrum, APT (Δ ω) represents amide proton transfer effect.LWaterAnd LMTIt is respectively that directly satisfying for water is fitted with Lorentzian
The formula obtained with effect and magnetization transfer effect.
Alternatively, the A2 is specifically included：
A21, the original Z spectrum is normalized and 180 ° of upsets are carried out.
A22, using normalization and upset after original Z spectrums and fitting Z spectrums difference as amide proton transfer effect.
After original Z spectrums are normalized and overturn, APT (Δ ω)=[1- (LWater+LMT)]-Z be changed into APT (Δ ω)=(1-Z)-
(LWater+LMT) it is, specific as shown in figure 3, in figure 3, circle represents the original Z spectrums for normalizing and carrying out 180 ° of upsets, other
Respectively represent fitting Z spectrum, fitting the direct saturation effect of water and fitting magnetization transfer effect.From the figure 3, it may be seen that water is directly satisfied
It is asymmetrical with effect and magnetization transfer effect.
Alternatively, the A22 is specifically included：
The difference that original Z spectrums after using normalization and upset are composed at+3.5ppm with the fitting Z turns as amide proton
Move effect.Fig. 4 shows that the original Z spectrums after normalization and upset compose the signal of the difference at+3.5ppm with the fitting Z
Figure.The difference of original Z spectrums and fitting Z spectrums is taken at+3.5ppm, it is possible to prevente effectively from offside -3.5ppm places Overhauser effect is dry
Disturb.
Alternatively, after the step S13, including：
Amide proton transfer effect in image is compared with standard amide proton transfer effect, is assessed according to comparative result
The health status of user.For example, it is assumed that standard amide proton transfer effect is the amide proton transfer effect for being not suffering from tumour, then when
When amide proton transfer effect in image is more or less the same with standard amide proton transfer effect, show the health of user preferably,
There is no tumour.
In first embodiment of the invention, image is read, and obtains the original Z of the pixel of described image and composed, using Lorentz
Function is fitted the direct saturation effect of water and fitting magnetization transfer effect respectively, and the water according to the original Z spectrums and fitting is straight
The magnetization transfer effect for connecing saturation effect and fitting determines amide proton transfer effect.Due to being fitted by Lorentzian
The direct saturation effect and magnetization transfer effect of the water of governing effect are accounted in Z spectrums, therefore, it can effectively solve both factors pair
The interference that amide proton transfer effect is calculated, so that the quantization of amide proton transfer effect is more reliable.
It should be understood that in embodiments of the present invention, the size of the sequence number of above-mentioned each process is not meant to the elder generation of execution sequence
Afterwards, the execution sequence of each process should be with its function and internal logic determination, the implementation process structure without tackling the embodiment of the present invention
Into any restriction.
Embodiment two：
Fig. 5 shows a kind of structure of the determining device of amide proton transfer effect that second embodiment of the invention is provided
Figure, the determining device of the amide proton transfer effect can be applied in mobile terminal, and the mobile terminal can be included through wirelessly connect
The user equipment that networking RAN is communicated with one or more core nets, the user equipment can be that mobile phone (or is
" honeycomb " phone), the computer with mobile device etc., for example, user equipment can also be portable, pocket, hand-held,
Built-in computer or vehicle-mounted mobile device, they exchange voice and/or data with wireless access network.Again for example, the shifting
Dynamic equipment can be including smart mobile phone, panel computer, personal digital assistant PDA, point-of-sale terminal POS or vehicle-mounted computer etc..In order to
It is easy to explanation, illustrate only the part related to the embodiment of the present invention.
The determining device of the amide proton transfer effect includes：Image fetching unit 51, interference fitting unit 52, amino matter
Sub- transfer effect determining unit 53.Wherein：
Image fetching unit 51, for reading image, and obtains the original Z spectrums of the pixel of described image.
Alternatively, the determining device of the amide proton transfer effect includes：
Main field corrects unit, for the minimum point that the original Z of the pixel is composed to be moved on at centre frequency 0ppm, with reality
The correction of the main field of existing magnetic resonance system.
Interference fitting unit 52, is turned for being fitted the direct saturation effect of water and fitting magnetization respectively using Lorentzian
Move effect.
Amide proton transfer effect determining unit 53, for the direct saturation effect of water according to the original Z spectrums and fitting
Amide proton transfer effect should be determined with the magnetization transfer effect of fitting.
Specifically, the direct saturation effect of water component corresponding with magnetization transfer effect can be directly filtered, or, in order to improve
Speed is filtered, the corresponding component of the direct saturation effect of part water can be also filtered and be filtered corresponding point of transfer effect of part magnetization
Amount, but need to ensure that the corresponding component of the direct saturation effect of remaining water component corresponding with magnetization transfer effect can not disturb original
Z is composed.
Alternatively, the amide proton transfer effect determining unit 53 is specifically included：
Fitting Z spectrum determining modules, the sum for determining the direct saturation effect of water of fitting and the magnetization transfer effect of fitting,
As fitting Z spectrums.
Difference calculating module, for the original Z to be composed into the difference composed with the fitting Z as amide proton transfer effect.
Specifically, the direct saturation effect of water being fitted is added with the magnetization transfer effect of fitting, is shown below：
L (A, Lw, Δ ω)=A/ [1+4 (Δ ω/Lw)2]；
APT (Δ ω)=[1- (LWater+LMT)]-Z；
Wherein, A is amplitude, and Lw is that frequency spectrum is wide, and Δ ω is the relative displacement of the resonant frequency relative to water, and Z represents original Z
Spectrum, APT (Δ ω) represents amide proton transfer effect.LWaterAnd LMTIt is respectively that directly satisfying for water is fitted with Lorentzian
The formula obtained with effect and magnetization transfer effect.
Alternatively, the difference calculating module is specifically included：
Frequency spectrum normalized module, overturns for being normalized and carrying out 180 ° to the original Z spectrums.
Amide proton transfer effect computing module, composes for the original Z spectrums after by normalization and upset with the fitting Z
Difference as amide proton transfer effect.
Specifically, original Z is composed after normalizing and overturning, APT (Δ ω)=[1- (LWater+LMT)]-Z is changed into APT
(Δ ω)=(1-Z)-(LWater+LMT).
Alternatively, the amide proton transfer effect computing module is specifically for the original Z after by normalization and upset
The difference with fitting Z spectrums at+3.5ppm is composed as amide proton transfer effect.
Alternatively, the determining device of the amide proton transfer effect includes：
Comparing unit, for the amide proton transfer effect in image to be compared with standard amide proton transfer effect, root
The health status of user is assessed according to comparative result.
In second embodiment of the invention, due to by Lorentzian fit Z compose in account for governing effect water it is straight
Saturation effect and magnetization transfer effect are connect, therefore, it can effectively solve what both factors calculated amide proton transfer effect
Interference, so that the quantization of amide proton transfer effect is more reliable.
Those of ordinary skill in the art are it is to be appreciated that the list of each example described with reference to the embodiments described herein
Unit and algorithm steps, can be realized with the combination of electronic hardware or computer software and electronic hardware.These functions are actually
Performed with hardware or software mode, depending on the application-specific and design constraint of technical scheme.Professional and technical personnel
Described function, but this realization can be realized it is not considered that exceeding using distinct methods to each specific application
The scope of the present invention.
It is apparent to those skilled in the art that, for convenience and simplicity of description, the system of foregoing description,
The specific work process of device and unit, may be referred to the corresponding process in preceding method embodiment, will not be repeated here.
In several embodiments provided herein, it should be understood that disclosed system, apparatus and method, can be with
Realize by another way.For example, device embodiment described above is only schematical, for example, the unit
Divide, only a kind of division of logic function there can be other dividing mode when actually realizing, for example multiple units or component
Can combine or be desirably integrated into another system, or some features can be ignored, or do not perform.It is another, it is shown or
The coupling each other for discussing or direct-coupling or communication connection can be the indirect couplings of device or unit by some interfaces
Close or communicate to connect, can be electrical, mechanical or other forms.
The unit that is illustrated as separating component can be or may not be it is physically separate, it is aobvious as unit
The part for showing can be or may not be physical location, you can with positioned at a place, or can also be distributed to multiple
On NE.Some or all of unit therein can be according to the actual needs selected to realize the mesh of this embodiment scheme
's.
In addition, during each functional unit in each embodiment of the invention can be integrated in a processing unit, it is also possible to
It is that unit is individually physically present, it is also possible to which two or more units are integrated in a unit.
If the function is to realize in the form of SFU software functional unit and as independent production marketing or when using, can be with
Storage is in a computer read/write memory medium.Based on such understanding, technical scheme is substantially in other words
The part contributed to prior art or the part of the technical scheme can be embodied in the form of software product, the meter
Calculation machine software product is stored in a storage medium, including some instructions are used to so that a computer equipment (can be individual
People's computer, server, or network equipment etc.) perform all or part of step of each embodiment methods described of the invention.
And foregoing storage medium includes：USB flash disk, mobile hard disk, read-only storage (ROM, Read-Only Memory), arbitrary access are deposited
Reservoir (RAM, Random Access Memory), magnetic disc or CD etc. are various can be with the medium of store program codes.
The above, specific embodiment only of the invention, but protection scope of the present invention is not limited thereto, and it is any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all contain
Cover within protection scope of the present invention.Therefore, protection scope of the present invention described should be defined by scope of the claims.
Claims (10)
1. a kind of determination method of amide proton transfer effect, it is characterised in that methods described includes：
Image is read, and obtains the original Z spectrums of the pixel of described image；
It is fitted the direct saturation effect of water and fitting magnetization transfer effect respectively using Lorentzian；
Determine that amide proton turns according to the original Z spectrums and the direct saturation effect of water of fitting and the magnetization transfer effect of fitting
Move effect.
2. method according to claim 1, it is characterised in that in the reading image, and obtain the pixel of described image
Original Z spectrum after, including：
The minimum point that the original Z of the pixel is composed moved on at centre frequency 0ppm, to realize the main field of magnetic resonance system
Correction.
3. method according to claim 1, it is characterised in that the water according to the original Z spectrums and fitting is direct
Saturation effect and the magnetization transfer effect of fitting determine amide proton transfer effect, specifically include：
It is determined that the sum of the direct saturation effect of water of fitting and the magnetization transfer effect of fitting, as fitting Z spectrums；
Using the difference of the original Z spectrum and fitting Z spectrums as amide proton transfer effect.
4. method according to claim 3, it is characterised in that the difference work that the original Z spectrums are composed with the fitting Z
It is amide proton transfer effect, specifically includes：
The original Z spectrums are normalized and 180 ° of upsets are carried out；
The difference of original Z spectrums after using normalization and upset and fitting Z spectrums is used as amide proton transfer effect.
5. method according to claim 4, it is characterised in that it is described by normalization and upset after original Z spectrums and institute
The difference of fitting Z spectrums is stated as amide proton transfer effect, is specifically included：
The difference that original Z spectrums after using normalization and upset are composed at+3.5ppm with the fitting Z is shifted as amide proton imitates
Should.
6. a kind of determining device of amide proton transfer effect, it is characterised in that described device includes：
Image fetching unit, for reading image, and obtains the original Z spectrums of the pixel of described image；
Interference fitting unit, for being fitted the direct saturation effect of water and fitting magnetization transfer effect respectively using Lorentzian
Should；
Amide proton transfer effect determining unit, for the direct saturation effect of water and plan according to the original Z spectrums and fitting
The magnetization transfer effect of conjunction determines amide proton transfer effect.
7. device according to claim 6, it is characterised in that described device includes：
Main field corrects unit, for the minimum point that the original Z of the pixel is composed to be moved on at centre frequency 0ppm, to realize magnetic
The correction of the main field of resonator system.
8. device according to claim 6, it is characterised in that the amide proton transfer effect determining unit is specifically wrapped
Include：
Fitting Z spectrum determining modules, the sum for determining the direct saturation effect of water of fitting and the magnetization transfer effect of fitting, to make
It is fitting Z spectrums；
Difference calculating module, for the original Z to be composed into the difference composed with the fitting Z as amide proton transfer effect.
9. device according to claim 8, it is characterised in that the difference calculating module is specifically included：
Frequency spectrum normalized module, overturns for being normalized and carrying out 180 ° to the original Z spectrums；
Amide proton transfer effect computing module, for the difference that the original Z spectrums after by normalization and upset are composed with the fitting Z
As amide proton transfer effect.
10. device according to claim 9, it is characterised in that the amide proton transfer effect computing module is specifically used
The difference that original Z spectrums after using normalization and upset are composed at+3.5ppm with the fitting Z is shifted as amide proton imitates
Should.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108195867A (en) * | 2017-12-18 | 2018-06-22 | 深圳先进技术研究院 | PH assay methods |
| CN110706199A (en) * | 2019-08-29 | 2020-01-17 | 西北大学 | Z spectrum fitting method based on pseudo-Poincke decoupling type and CEST MRI quantification method |
| CN113674248A (en) * | 2021-08-23 | 2021-11-19 | 广州市番禺区中心医院(广州市番禺区人民医院、广州市番禺区心血管疾病研究所) | Magnetic resonance amide proton transfer imaging magnetic susceptibility detection method and related equipment |
| WO2023108314A1 (en) * | 2021-12-13 | 2023-06-22 | 中国科学院深圳先进技术研究院 | Main magnetic field three-dimensional non-uniformity correction method, apparatus and device, and storage medium thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103472419A (en) * | 2013-08-30 | 2013-12-25 | 深圳先进技术研究院 | Magnetic-resonance fast imaging method and system thereof |
| US8686727B2 (en) * | 2010-07-20 | 2014-04-01 | The Trustees Of The University Of Pennsylvania | CEST MRI methods for imaging of metabolites and the use of same as biomarkers |
| CN104997511A (en) * | 2015-06-01 | 2015-10-28 | 中国科学院深圳先进技术研究院 | CESTR measuring method and system for magnetic resonance chemical exchange saturation transfer imaging |
| CN204925368U (en) * | 2015-08-12 | 2015-12-30 | 上海联影医疗科技有限公司 | A radio frequency emission coil and magnetic resonance imaging equipment for magnetic resonance imaging equipment |
-
2016
- 2016-12-30 CN CN201611270858.5A patent/CN106772165B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8686727B2 (en) * | 2010-07-20 | 2014-04-01 | The Trustees Of The University Of Pennsylvania | CEST MRI methods for imaging of metabolites and the use of same as biomarkers |
| CN103472419A (en) * | 2013-08-30 | 2013-12-25 | 深圳先进技术研究院 | Magnetic-resonance fast imaging method and system thereof |
| CN104997511A (en) * | 2015-06-01 | 2015-10-28 | 中国科学院深圳先进技术研究院 | CESTR measuring method and system for magnetic resonance chemical exchange saturation transfer imaging |
| CN204925368U (en) * | 2015-08-12 | 2015-12-30 | 上海联影医疗科技有限公司 | A radio frequency emission coil and magnetic resonance imaging equipment for magnetic resonance imaging equipment |
Non-Patent Citations (2)
| Title |
|---|
| 梁立: "基于CEST理论模型的优化采样方案研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
| 郭文莎等: "基于快速梯度回波序列的氨基质子转移成像", 《集成技术》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108195867A (en) * | 2017-12-18 | 2018-06-22 | 深圳先进技术研究院 | PH assay methods |
| CN108195867B (en) * | 2017-12-18 | 2019-10-18 | 深圳先进技术研究院 | PH measuring method |
| CN110706199A (en) * | 2019-08-29 | 2020-01-17 | 西北大学 | Z spectrum fitting method based on pseudo-Poincke decoupling type and CEST MRI quantification method |
| CN110706199B (en) * | 2019-08-29 | 2022-12-27 | 西北大学 | Z spectrum fitting method based on pseudo-Poinck elimination line type and CEST MRI quantification method |
| CN113674248A (en) * | 2021-08-23 | 2021-11-19 | 广州市番禺区中心医院(广州市番禺区人民医院、广州市番禺区心血管疾病研究所) | Magnetic resonance amide proton transfer imaging magnetic susceptibility detection method and related equipment |
| WO2023108314A1 (en) * | 2021-12-13 | 2023-06-22 | 中国科学院深圳先进技术研究院 | Main magnetic field three-dimensional non-uniformity correction method, apparatus and device, and storage medium thereof |
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