CN106725249A - Accurate medicine equipment - Google Patents

Abstract

The invention discloses a kind of accurate medicine equipment, including the operating side, rope pipe and the actuating station that are linked in sequence, doctor or assistant are controlled in vitro from operating side, performing has at least one hole on the wall of side, the end of multiple axostylus axostyles is set near hole, and at least one fix sacculus, needle-like member, imaging lens and an auxiliary balloon at the top of axostylus axostyle, and dividing plate is provided between sacculus and needle-like member, the dividing plate is welded on the inside of actuating station and with amount of deflection.The present invention can be carried out actuating station remotely located by location technology, it is to avoid situation about rotating occur, and raising is punctured, sampling precision.

Description

Accurate medicine equipment

Technical field

The present invention relates to be used to transmit Medical Devices or apparatus in body cavity and tissue and adjacent to body cavity and the spy of tissue Determine the method and system of cell position.

Background technology

When diagnosing and treating the disease of various body cavitys and organ, it is necessary to various medicine equipments are delivered into organ and organization department In the ad-hoc location of position.

Generally, in addition it is also necessary to the blood vessel and other human body devices that medicinal or treatment material is sent to distal end and is not easily accessible In the tube chamber of official such as lung.The cytotoxic therapy of limiting dose and diagnostic substances can be conveyed directly in target tissue It is critically important, because such material is often very expensive, or can be caused serious injury if transmission excess.Accordingly, it would be desirable to one Plant the device that therapeutic and diagnostic medicament can be conveyed directly to the target tissue in human body.

And it is desirable to for various medicine equipments and equipment to introduce target tissue to aid in carrying out drug therapy or related Treatment or diagnosis process, such as biopsy, radiation therapy, open the method for cutting, laser therapy etc..Such equipment must generally be inserted into To distal end and the body lumen that is not easily accessible, and guided by the tube chamber, be then accurately positioned that desired doctor can be carried out Treatment process.

Some equipment are planned to for internally body cavity orientation transmission medicine.For example, being used for the endarterial spy of patient Positioning puts the conduit of injection medicine.The conduit includes two respectively positioned at the medicine transmission pin at catheter shaft two ends, can also include Between pin for the balloon-expandable that outwards pushes pin in inflation.During use, conduit is inserted into patient In vivo, sacculus expansion, pin stretches out from the transfer port of sacculus side.

System for be by the ad-hoc location that medicine and related medical apparatus/equipment are sent in patient's body it is useful, these System still has many shortcomings and defect.Especially, the sharp parts of medicine transmission pin or other Medical Devices inserting in equipment Enter or revocation procedure is contact surrounding tissue, or surrounding tissue is contacted suddenly when protective case is removed.Which increase The possibility of surrounding body cavity and tissue noxious insult during equipment operation.Furthermore it is known that equipment does not provide prevention medicine Transmission pin or other sharp instruments surprisingly pierce through the security mechanism of balloon-expandable in the process.

Particularly, syringe needle position is susceptible to reversion so that precise decreasing, another defect of above-mentioned prior art systems It is equally optimal and be precisely located during to be them expect without the image of Buddha.

Just as the problem mentioned in the A of CN 104902953, the pointed end tip of pin there is a problem of puncturing sacculus, This problem must be controlled by other any suitable modes of such as acoustic control or robot, it is very difficult to be controlled.

Therefore, it is desirable to it is a kind of improved for sending various medicine equipments and equipment in patient's body ad-hoc location System and method are improved, the system and method can solve the shortcoming and defect of above-mentioned prior art systems.

The content of the invention

To realize at least the above purpose of the present invention, the present invention starts with from the precision for improving medicine equipment, using end Location technology, changed in the moment for puncturing, and pin easily produces the problem of deflection, while solution imaging lens are easily contaminated asking Topic.And a kind of gram of function being smoothly sampled to pathological tissues is provided.

Particular content

Accurate medicine equipment, including operating side, rope pipe and the actuating station being linked in sequence, doctor or assistant enter from operating side The external control of row, it is characterised in that

Flexible, the rigid or semirigid interior passage that there is appearance axostylus axostyle to pass through of rope pipe；

The end on the wall of the execution side with least one hole, multiple axostylus axostyles is set near hole, and at least one A sacculus is fixed at the top of individual axostylus axostyle, a needle-like member, the end of at least one axostylus axostyle are fixed in the end of at least one axostylus axostyle An imaging lens are fixed in portion, and an auxiliary balloon for inflated condition is fixed in the end of at least one axostylus axostyle, block hole, and Dividing plate is provided between sacculus and needle-like member, the dividing plate is welded on the inside of actuating station and with amount of deflection.

The end of the actuating station is provided with optical fiber image beam.

Positioner is provided near actuating station, the positioner includes auxiliary noose and struts air bag, wherein auxiliary Help noose circumferentially to form 2 to 3 holes, and it is described strut inner chamber in the state of air bag is strutted at least retain 50% it is unobstructed logical Road.

Positioner is provided near actuating station, the positioner includes being positioned close in the rope pipe of actuating station Chamber and in a chamber strut air bag.

Also include a sampler, three arc valvular structures in the sampler are fixed on an elastomer On, elastomer has one using memorial alloy or with elastomeric alloy components between arc valvular structure and elastomer Transition Zone of Deformation, the presence of the Transition Zone of Deformation so that three arc valvular structures have the trend opened, by pulling Cable wire so that arc valvular structure closes up and retracts into inside axostylus axostyle.

Beneficial effect：

By location technology, actuating station can be carried out remotely located, it is to avoid situation about rotating occur, improve and puncture, take Sample precision.

By sampling technique, it is possible to achieve remote control is sampled, in order to carry out the slice analysis of pathological tissues.

Dividing plate is set, overall security performance is improve, once success rate can be especially improved.

Brief description of the drawings

Fig. 1 is the schematic diagram for transmitting the system of guided by saccule medicine equipment of the invention.

Fig. 2 is the amplification stereogram of actuating station.

Fig. 3 is the stereogram of the another embodiment of actuating station.

Fig. 4 is Fig. 2 cross-sectional views.

Fig. 5 is another state of Fig. 4.

Fig. 6 is the execution state of Fig. 5.

Fig. 7 is the another embodiment of Fig. 6.

Fig. 8 is the another state of Fig. 7.

Fig. 9 is another embodiment.

Figure 10 is the another state of Fig. 9.

Figure 11 is the another embodiment of Figure 10.

Figure 12 is the another embodiment of Figure 10.

Figure 13 is the another embodiment of Figure 10.

Figure 14 is the stereogram of sampler.

By the following drawings and detailed description, other objects of the present invention and its specific features and advantage will become brighter It is aobvious.

Specific embodiment

Fig. 1 shows the basic module for transmitting an embodiment of sacculus guided medical apparatus of the invention, whole The basic condition of individual component belongs to prior art, is widely applied and in medical treatment, for example, the knot of operating side Structure.The term " top " that is used in description, " bottom ", " ... above ", " ... below ", " ... on ", " ... under ", " up ", " in lower section ", " above ", " below ", " on ", D score, " upper strata ", " lower floor ", With reference to being cited when " front ", " rear ", " below ", " onwards " and " backward " is in orientation shown in the drawings Object, the orientation is for realizing what target of the invention was not required.

It is of the invention to enter for transmitting the ad-hoc location that the system of sacculus guided medical apparatus can be used in patient's body The various diagnosis of row and/or therapeutic process.For example, the present invention can be used to transmit medicine, radiotherapy, chemotherapy, drug therapy, treatment Medicament, immunotherapy, biological products, biomarker, radiopaque contrast, diagnostic medicament and for such as tubular structure, tubulose What the specific cells of the interior and neighbouring body cavity of the body cavity in organ lumen, pleural cavity, air flue, blood vessel, organ, bone and joint etc. were positioned Correlation technique.

Fig. 1 shows the exemplary embodiment for transmitting the system of sacculus guided medical apparatus of the invention. Including operating side 100, rope pipe 200 and actuating station 300.

Operating side 100, mainly including pump, the operation of pin, the operation of optical fiber, doctor or assistant can control system from the pump System is controlled in vitro, and control gimmick can seek advice from the medical personnel first closed.The effect of pump is to by sacculus, auxiliary gas Capsule, airbag aeration is strutted, and realize that pressure etc. is controlled.Inflation provides the fluid of such as gas, liquid or its mixture.

Rope pipe 200 can have it is any depending on the concrete application in target body chamber and/or the suitable diameter of volume and length, And can be flexible, rigid or semirigid, according to medical science general knowledge, the material flexibility of rope pipe enables axostylus axostyle by body cavity enough It can be seen that opening safety is inserted, the axostylus axostyle will be turned to rather than puncture rope pipe along cavity wall.What deserves to be explained is, the distant place of rope pipe 200 Actuating station 300 is made flexible to insert in body cavity with ensureing axostylus axostyle energy safety and hurtless measure.

Multiple passages can be arranged as required in above-mentioned rope pipe, for the installation of multiple axostylus axostyles.

In certain embodiments, rope pipe 200 can include the coating being made up of suitable smooth material, to promote axostylus axostyle to lead to Cross the movement of body cavity.In some preferred embodiments, rope tube wall can be made up of any suitable material such as stainless steel Winding wire, and coating that such as polyethylene, polyurethane, polyetheramides etc. suitable material are made composition.Can also use Braiding jacket replaces winding wire.In some preferred embodiments, winding wire or braiding jacket can be closed with such as Nitinol The shape-memory material of gold is made.

In a further preferred embodiment, rope pipe 200 can include weaving the combination of jacket and winding wire material carrying For the optimum flexibility and operability of axostylus axostyle.Consider in the present invention, have supporting construction in actuating station 300, the rope pipe can be used More soft material, to improve the comfortableness of human body during poling, it is to avoid cause to damage to inner chamber.

As shown in Fig. 2 more details, actuating station 300, axostylus axostyle 201 can use all any suitable material systems described above Into, and any suitable diameter and length can be had according to the concrete application of targeting body cavity and/or volume.

Axostylus axostyle 201 has the balloon-expandable 202 at the top for being disposed proximate or at distal end.Balloon-expandable 202 can be by Latex, polyurethane, silica gel, polybutadiene, high modulus polyurethane or other suitable materials are made, and can be according to concrete application system Into various sizes and diameter.Flexible sacculus is used in some preferred embodiments.In a further preferred embodiment, inflatable ball Capsule 202 can include multiple balloon/vesicas, the mutual control of balloon/vesica, it is inflatable and deflatable be incoherent.

For further details, please refer to Fig. 1 to Figure 14.

As shown in fig. 6, axostylus axostyle 201 is multiple, wherein at least has one to be used to expand it to the offer fluid of sacculus 202 Interior lumen, and be connected with the pump class apparatus of operating side.

In certain embodiments, pump is capable of identify that the type of the system being attached thereto, and reads the such as maximum pressure of sacculus The characteristics such as power, volume, size, are then based on user input and correspondingly adjust its control.

Pump can also include the place that the fluid supply based at least one parameter preset to balloon-expandable 202 is controlled Reason device.In certain embodiments, the parameter preset can be manually entered by user.Pump can be selected by monitoring and considering patient The vital sign and pathological parameter of such as body temperature, heart rate, blood pressure and respiratory rate are controlled and adjust pressure.

Actuating station 300, as shown in Fig. 2 with the hole 301 in its side wall.Hole 301 is according to the balloon type for using Can have any suitable profile and size with the specific Medical Devices/apparatus for being transmitted.Preferably, hole is sufficiently large To accommodate the sacculus 202 in fully expanded state, when sacculus expands completely, its part extends outside output shaft lever, such as Fig. 7 institutes Show.

As shown in fig. 7, the opening of hole 301 extends the girth less than the half of axostylus axostyle 201.Though it should be noted that at some In embodiment, the opening of hole 301 can extend according to concrete application and the device type for being transmitted and significantly exceed or be significantly less than The girth of axostylus axostyle half.

As shown in figure 4, needle-like member 302 is movably disposed in rope pipe, and needle-like member can be reserved in rope pipe 200 The passage for passing through.Needle-like member 302 is included in elongated tubular of its top with least one opening, for injecting medicine.This is opened Mouth is fluidly connected to for the needle cavity to treatment and/or diagnostic medicament needed for tissue transmission.Needle-like member 302 using stainless steel or The material of any bio-compatible of plastics is made, and there is the material enough flexibilities to enable the top of needle-like member 302 in sacculus 202 bend certain angle when once expansion, as shown in Figure 4.

One dividing plate of alloy 304 is set in the rope pipe between needle-like member and air bag, it is preferential other using medical grade Stainless steel flexure strip, implements isolation, it is to avoid needle-like member causes maloperation to air bag, it is to avoid explosion to needle-like member and air bag Risk.

Dividing plate 304 has for needle-like member provides the effect being oriented to, and is welded on the inside of actuating station, can be carried out with amount of deflection Deformation, forms favourable natural torsion.Dividing plate 304 can also have the outer wall with the such as grain surface of woven mesh thing, Guide effect is provided, grain surface contributes to accurate guiding and placement doctor by ensureing that medicine equipment will not slide from baffle surface Apparatus is treated, and also assures that the expansion in expansion process evenly of sacculus 202.

Additionally, the interior lumen of needle-like member 302 can accommodate the medicine equipment or equipment for being used for certain operation. In certain embodiments, needle-like member 302 can obtain the tissue samples for biopsy by the opening in its top.

When sacculus 202 is adjusted, due to the presence of dividing plate 304, make medicine equipment/equipment relative to the orientation of sacculus Do not changed when sacculus expands, pin diametrically has certain rigidity, by the guide frame on dividing plate, for example, pin Irregular slip will not be carried out relative to sacculus.

Picture reproducer and/or lighting apparatus can also be used together with system of the invention.In certain embodiments, pass through The interface for being located at near-end is introduced through the optical fiber image beam at the center of axostylus axostyle 201 to form the image of peripheral region.Optical fiber image beam 203 can by the incoherent fibre bundle for illuminating, and core coherent image fibre bundle, and lens are made.Beam 203 can be wrapped Include the various types of object lens for being used for the different visuals field (such as 50 °, 130 ° etc.) and various pentrutions positioned at top tip.Can be with Using two different beams, one is used to illuminate, and another is used to image.On the top of fibre bundle 203, image coherent fiber with Illumination fiber is mutually independent and the imageing sensor of such as CMOS or CCD is linked into by suitable optical element.Similarly, illuminate Fiber is linked into light source.It should be noted however, that the light source of other such as light emitting diodes can also be used.Should also note Meaning is that imageing sensor may be located at the tip for imaging pipe guide, eliminates necessity of coherent image fibre bundle, therefore carry Picture quality high simultaneously reduces cost.

Image and/or lighting apparatus is for doctor or user provide the straight of illumination light, non-thermal energy illumination light and peripheral region Connect visual feedback.In some preferred embodiments, imaging/lighting apparatus is extended by hole 301, with during performing the operation illumination and The imaging of target tissue site, and the conveniently placement of the medicine equipment of such as pin are provided.The imaging on the top of picture reproducer such as beam Camera lens 204 is preferably the ability with rotation brake, therefore allows the visualization of 360 ° of area for treatment.

During actuating station is delivered into treatment position, actuating station is needed by long-term process, during this, Human internal organs and tissue can be polluted to the optical fiber at hole 301, imaging lens 204 etc., in the present invention after consideration Solved using auxiliary balloon 303, auxiliary balloon uses smooth appearance, in the case where auxiliary balloon 303 is softened, gas Capsule can fill redundant space.The initial position of pin should avoid the space.

After reaching precalculated position, needle-like member is released, and can be punctured auxiliary balloon 303, and such imaging lens 204 can Be to lean out, during leaning out clearly, it is free of contamination, then, carry out the corresponding adjustment of position.

With reference to Figure 11, at the front end position of actuating station 300, a positioner 400 for auxiliary, the positioner bag are set Include auxiliary noose 401, strut air bag 402, wherein auxiliary noose 401 carries out perforate, circumferentially form 2-3 hole 403, its support After opening airbag aeration, some can be leant out to the outside of hole, and is resisted against on the wall of human intracavity, formed a kind of three-jaw and determined Position, results in blockage in order to avoid strutting air bag to inner chamber, and the above-mentioned air bag 402 that struts should be using small size, in other words, hole 403 should use narrow gap, and so that inner chamber at least retains 50% clear path, it is to avoid human body produces sense of discomfort.

With reference to Figure 13, positioner is positioned close in the rope pipe 200 of actuating station, and space at is opened up in rope pipe 200, For accommodate it is above-mentioned strut air bag 402, strut under inflated condition for and internal chamber wall contacted, form support.

Improved as one kind, in the operations such as tissue sample, tissue measurement, cutting tissue are carried out, in the end of axostylus axostyle 201 One sampler 500 is set, and the device uses three valve structures, specifically, three arc valvular structures 501 are fixed on a bullet On gonosome 502, elastomer is had using memorial alloy or with elastomeric alloy components between arc valvular structure and elastomer Have a Transition Zone of Deformation 503, the presence of the Transition Zone of Deformation so that three arc valvular structures have one open become Gesture, by pulling cable wire 404 so that arc valvular structure 501 closes up and retracts into inside axostylus axostyle.Group is inserted into for convenience Inside is knitted, the tip of valvular structure is the piercing shape of point, and the sampling of tissue is realized by closing up.

Valvular structure has the rigidity more strengthened than elastomeric element so that the tissue of sampling is bound in inside it.

Above-mentioned axostylus axostyle is set to multiple as needed.

It is as follows using process：

First, actuating station is delivered to the position for needing to carry out accurate treatment, is then acted by pin and is punctured auxiliary balloon, Release probe or imaging lens, the regional location for treating accurate treatment is observed by imaging system, and actuating station is carried out as needed The fine setting of position, the mode of fine setting includes moving radially and circumferential rotation, carries out strutting the inflation of air bag afterwards in place, is held The positioning at row end, due to strutting the effect of air bag, support, and support tightly is formed in inner chamber, such as, gas in the end of actuating station Pipe, esophagus, pulmonary passages etc., then start the inflation of air bag, and the angle of angle and pin according to dividing plate controls filling for air bag Tolerance, appropriate start and stop, is observed during this by imaging lens, the pin institute energy such as is injected, punctured, be administered afterwards in place The work of completion.

Needle-like member 302 can be moved further into tissue 600 to reach predetermined penetration depth or such as be organized Sampling, tissue measurement, cutting tissue etc. necessary step.Using needle-like member illustrated embodiment in, by needle cavity to Tissue supply treats and/or diagnostic medicament.Sacculus can repeatedly deflate and inflate position to adjust needle-like member 302 or to group Knit cyclic transfer medicine.

Used as another structure, three arc flaps can be sampled by opening, and the mode then closed up is sampled.

After needing step to be all finished, sacculus 202 is deflated, and needle-like member 302 is distally moved to non-toggle The top tip of state, wherein pin is enclosed completely by axostylus axostyle 201.Then, air bag deflation, actuating station safety from patient's body are strutted Take out.

Embodiment described above is only that the preferred embodiment of the present invention is described, not to model of the invention Enclose and be defined, on the premise of design spirit of the present invention is not departed from, relevant technical staff in the field is to various changes of the invention Shape and improvement, all should expand in the protection domain as determined by claims of the present invention.

Claims (5)

1. accurate medicine equipment, including operating side (100), rope pipe (200) and the actuating station (300) being linked in sequence, doctor or helps Hand is controlled in vitro from from operating side (100), it is characterised in that

Flexible, the rigid or semirigid interior passage that there is appearance axostylus axostyle to pass through of rope pipe (200)；

The end on the wall of actuating station (300) side with least one hole (301), multiple axostylus axostyles is set near hole, and A sacculus (202) is fixed at the top of at least one axostylus axostyle (201), a needle-like member is fixed in the end of at least one axostylus axostyle, An imaging lens (204) is fixed in the end of at least one axostylus axostyle, and inflated condition is fixed in the end of at least one axostylus axostyle Auxiliary balloon (303), blocks hole, and dividing plate (304), the dividing plate are provided with and needle-like member between in sacculus (202) (304) it is welded on the inside of actuating station and with amount of deflection.

2. accurate medicine equipment according to claim 1, it is characterised in that the end of the actuating station is provided with light Fine image beams (203).

3. accurate medicine equipment according to claim 1, it is characterised in that be provided with positioning near actuating station (300) Device (400), the positioner includes auxiliary noose (401) and struts air bag (402), wherein auxiliary noose (401) is along week To forming 2 to 3 holes (403), and it is described strut inner chamber in the state of air bag (402) is strutted at least retain 50% it is unobstructed logical Road.

4. accurate medicine equipment according to claim 1, it is characterised in that be provided with positioning near actuating station (300) Device (400), the positioner includes being positioned close to chamber in the rope pipe (200) of actuating station and in a chamber Strut air bag (402).

5. accurate medicine equipment according to claim 1, it is characterised in that described also including a sampler (500) Three arc valvular structures (501) in sampler are fixed on an elastomer (502), elastomer using memorial alloy or Person has elastomeric alloy components, has a Transition Zone of Deformation (503) between arc valvular structure and elastomer, and this deformed Cross the presence in area so that three arc valvular structures have the trend opened, by pulling cable wire (404) so that arc Valvular structure (501) closes up and retracts into inside axostylus axostyle.