CN106580303A - Method for correcting systolic pressure-related pulse wave propagation time - Google Patents

Method for correcting systolic pressure-related pulse wave propagation time Download PDF

Info

Publication number
CN106580303A
CN106580303A CN201611045054.5A CN201611045054A CN106580303A CN 106580303 A CN106580303 A CN 106580303A CN 201611045054 A CN201611045054 A CN 201611045054A CN 106580303 A CN106580303 A CN 106580303A
Authority
CN
China
Prior art keywords
toe
pulse wave
ear
propagation time
systolic pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201611045054.5A
Other languages
Chinese (zh)
Other versions
CN106580303B (en
Inventor
陈妍
陈瑜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang Pulse Union Medical Equipment Co Ltd
Original Assignee
Zhejiang Pulse Union Medical Equipment Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Pulse Union Medical Equipment Co Ltd filed Critical Zhejiang Pulse Union Medical Equipment Co Ltd
Priority to CN201611045054.5A priority Critical patent/CN106580303B/en
Publication of CN106580303A publication Critical patent/CN106580303A/en
Priority to PCT/CN2017/098155 priority patent/WO2018095083A1/en
Priority to JP2019541843A priority patent/JP6736110B2/en
Priority to EP17874481.9A priority patent/EP3545832B1/en
Priority to PCT/CN2017/111799 priority patent/WO2018095291A1/en
Application granted granted Critical
Publication of CN106580303B publication Critical patent/CN106580303B/en
Priority to US16/391,287 priority patent/US20190246919A1/en
Priority to US17/874,618 priority patent/US20220378307A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0285—Measuring or recording phase velocity of blood waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7217—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

The invention belongs to the technical field of arterial blood pressure measurement and provides a method for correcting systolic pressure-related pulse wave propagation time, and the method can provide adaptive correction for the change in systolic pressure-related pulse wave propagation time due to the factors such as blood and liquid transfusion, vasoactive drugs, and surgical intervention under clinical conditions. The change in the systolic pressure-related pulse wave propagation time is corrected herein by: detecting in real time, auricular pulse wave and toe pulse wave in a same cardiac cycle, calculating the systolic pressure-related pulse wave propagation time, and extracting correcting variables according to morphological characteristics of the pulse waves to obtain a correcting matrix; the corrected propagation time is applicable to existing mathematical models to continuously measure the systolic pressure in each cardiac cycle under clinical conditions, and measuring accuracy is high.

Description

The bearing calibration of the pulse wave propagation time related to systolic pressure
Technical field
The present invention relates to arteriotony field of measuring technique, and in particular to the pulse wave transmission time related to systolic pressure Bearing calibration.
Background technology
Arteriotony is to reflect one of blood circulation state, leading indicator of assessment organ perfusion, is Perioperative Care Important vital sign parameter.At present the conventional monitoring of blood pressure method of perioperative can be divided into invasive measurement and non-invasive measurement.Have Wound measurement is referred to inserts pipe special in the blood circulation of body, and mechanical potential is converted into after electronic signal by transducer The technology of real-time display of blood pressure change on custodial care facility.Invasive measuring method can continuously, accurately measure pulse blood pressure, but The danger that it is likely to result in also can not be ignored with injury.The conventional method of non-invasive measurement is cuff oscillographic method, this technical operation It is simple and degree of accuracy has obtained clinical accreditation, it is widely used in health examination and Perioperative Nursing.But, cuff oscillographic method can only Blood pressure is discontinuously measured every 3-5 minutes, it is impossible to the change of real-time tracking arteriotony.
For this purpose, medical circle proposes continuous non-invasive impulse blood pressure measuring technology, wherein using pulse wave propagation time/speed (PTT/PWV) continuous non-invasive measurement often wins the method for blood pressure and is increasingly becoming the focus of research.The measuring method passes through one or many Individual photoelectric sensor and one group of electrocardioelectrode synchronization gain volume pulsation wave (PhotoPlethysmoGraphy PPG) and electrocardio Signal (ECG), using the time difference between the time difference between PPG and ECG or two PPG PTT/PWV is calculated；Explore PTT/ Functional relationship and founding mathematical models between PWV and blood pressure, using measurable PTT/PWV blood pressure is estimated.It is many academic Paper is reported and the principle for often winning blood pressure is measured using PTT/PWV continuous non-invasives, such as Yan Chen, Changyun Wen, Guocai Tao,Min Bi,and Guoqi Li《A Novel Modeling Methodology of the Relationship Between Blood Pressure and Pulse Wave Velocity》；Yan Chen, Changyun Wen,Guocai Tao and Min Bi《Continuous and Noninvasive Measurement of Systolic and Diastolic Blood Pressure by One Mathematical Model with the Same Model Parameters and Two Separate Pulse Wave Velocities》；Younhee Choi,Qiao Zhang,Seokbum Ko《Noninvasive cuffless blood pressure estimation using pulse transit time and Hilbert–Huang transform》；Zheng Y,Poon CC,Yan BP,Lau JY《Pulse Arrival Time Based Cuff-Less and 24-H Wearable Blood Pressure Monitoring and its Diagnostic Value in Hypertension》；Mukkamala R,Hahn JO,Inan OT,Mestha LK, Kim CS,H,Kyal S《Toward Ubiquitous Blood Pressure Monitoring via Pulse Transit Time:Theory and Practice》.Many patents disclose and often win blood using the measurement of PTT/PWV continuous non-invasives The specific implementation method or device of pressure, such as Chinese patent CN101229058A, CN102811659A, CN1127939C, the U.S. Patent 5865755,5857975,5649543,9364158 and European patent 0413267 etc..
The methods and techniques of existing utilization PTT/PWV measurements blood pressure are required for using traditional cuff oscillographic method measurement one To carry out, the reasons why initial calibration, calibration is PTT/PWV to individual or one group of pressure value and the dependency relation of blood pressure is object dependency, There is the relation of determination between each individual PTT/PWV and blood pressure, the purpose of calibration is to determine the number being adapted with object Learn model parameter.
However, existing method has certain limitation, blood circulation is can be only applied to not by the condition of external interference Under.Because only that under the conditions of glitch-free, PTT just has stronger regularity with the relation of blood pressure for individuality, just may be used Can be described by the function of determination and mathematical model.But in peri-operation period, the blood circulation of patient liquid undergoing treatment, medicine, Under the influence of the Confounding Factor such as operation technique, temperature, PTT can occur a series of ANOMALOUS VARIATIONS, using the PTT of mutation and intrinsic Mathematical model can produce larger error estimating blood pressure.Because the PTT of mutation no longer has the rule for determining with the relation of blood pressure Rule property, even if the mutation that PTT is adapted to by frequent calibration mathematical model parameter does not solve root problem yet, it is impossible to which satisfaction is faced Requirement of the bed measurement to accuracy and real-time.
The content of the invention
For the defect of prior art, the present invention provides a kind of bearing calibration of pulse wave propagation time PTT, can be directed to Passed by pulse wave related to systolic pressure caused by the reasons such as blood transfusion and infusion, vasoactive agent, operation intervention under clinical condition Mutation between sowing time carries out self adaptive correction, and accuracy is high.
The bearing calibration of the pulse wave propagation time related to systolic pressure, comprises the following steps：
S1) pulse wave and analysis obtains the data below of ear pulse wave at ear under each cardiac cycle of real-time detection： The height h of aortic valve closing point on ear pulse wavesd, the systole time t of ear pulse waves, unit is millisecond, ear arteries and veins Fight the relaxing period time t of rippled, unit is millisecond, maximum height h of ear pulse wavemax；
S2) pulse wave and analysis obtains the data below of toe pulse wave at toe under each cardiac cycle of real-time detection： The systole time t of toe pulse waves-toe, unit is millisecond, the relaxing period time t of toe pulse waved-toe, unit is millisecond, Maximum height h of toe pulse wavemax-toe, the time t of the starting point of toe pulse wave to crest midpointch-toe, unit is in the least Second, the time t of the starting point of toe pulse wave to crest peakmax-toe, unit is millisecond；The crest midpoint refers to crest The rising edge turning point at place and the midpoint of trailing edge turning point；
S3) the pulse wave propagation time T related to systolic pressure is calculateds, the TsRefer to the aortic valve on ear pulse wave Point is closed to the time difference of the aortic valve closing point on toe pulse wave；H is ear pulse wave or toe pulse wave in the longitudinal axis Amplitude on direction；
S4) using the data obtained by step S1, S2 under same cardiac cycle, it is calculated school under the cardiac cycle Positive variable；
S5) according to the correcting variable under the cardiac cycle of step S4 acquisition, it is calculated under the cardiac cycle and corrects square Battle array；
S6 the correction matrix under multiple cardiac cycles) is continuously obtained, to the T obtained by step S3sIt is corrected；.
Preferably, the correction matrix in step S5aiFor the i-th correcting variable in correcting variable.
Preferably, step S6 is specially：Continuously acquire the correction matrix under 8 cardiac cycles.Bearing calibration is： Tsma=Tsm(1-Am)；Wherein,AiFor the correction matrix under i-th cardiac cycle, TsiFor the T under i-th cardiac cycles。
Preferably, one variable a of the correction1It is calculated by below equation：
If d1≤ksd-m-0≤d1-2, then a1=(d1-2-ksd-m-0)×0.50；
If ksd-m-0<d1, then a1=28 × 0.50；
If ksd-m-0>d1-2, then a1=0；
Wherein,d1=76～84, d1-2=104～112.
Preferably, second correcting variable a2It is calculated by below equation：
If ksd-m>(d2+ (age-14)/15/100), then a2=ksd-m-(d2+(age-14)/15/100)；
If ksd-m≤(d2+ (age-14)/15/100), then a2=0；
Wherein, if | ksd-m-0-ksd-m-ts| >=40 and (ksd-m-0+ksd-m-ts)/2≥ksd-m-2, then ksd-m=2 × ksd-m-2- (ksd-m-0+ksd-m-ts)/2, otherwise ksd-m=ksd-m-2；
Age is the age, d2=1.17 ～1.27.
Preferably, the 3rd correcting variable a3It is calculated by below equation：
If c4<kd-m-a<c5, then a3=0；
If ksd-m-0<d6Or ksd-m-2>d7, then a3=0；
If ksd-m-0≥d6+ 0.10 and ksd-m-2≤d8And kd-m-a≤c4, then a3=(c4-kd-m-a)×67/100；
IfOrThen a3=(c4-kd-m-a)×50/100；
If ksd-m-0≥d6+ 0.10 and ksd-m-2≤d8And kd-m-a≥c5, then a3=(c5-kd-m-a)×62/100；
IfOrThen a3=(c5-kd-m-a)×45/100；
Wherein, if | ksd-m-0-ksd-m-ts| >=40 and (ksd-m-0+ksd-m-ts)/2≥ksd-m-2And ksd-m-ts≥d3-2, then, otherwise
If ksd-m-ts≤d3-2, thenIfThenIfThen c4= (d4+ (age-14)/8)/100, d4=23～35, c5=(d5+ (age-14)/8)/100, d5=27～39, d6=0.97～ 1.03, d7=1.52～1.58, d8=1.42～1.48, d3-2=1.21～1.31, d3=0.02～0.14, age are the age.
Preferably, the 4th correcting variable a4It is calculated by below equation：If ks-t-toe>0.8, then a4= ks-t-toe-0.8；
If ks-t-toe≤ 0.8, then a4=0；
Wherein, if tmax-toe≥tch-toe, thenOtherwise
Preferably, the 5th correcting variable a5It is calculated by below equation：
If ks-m-toe<d9, then a5=0；
If ks-m-toe≥d9And ks-t-toe>=0.8 a5=ks-m-toe-d9；
If ks-m-toe≥d9And ks-t-toe<0.8, then a5=(ks-m-toe-d9)/2；
Wherein, d9=0.67～0.73,
Preferably, the 6th correcting variable a6It is calculated by below equation：
If ks-m-toe-ear<1.0, then a6=0；
Work as ks-m-toe-ear>1.08, then c6=1.08, now, if ts>220 and ksd-m-0>0.88, then a6=c6- 1.0, if ts <160 or ksd-m-0<0.80, then a6=(c6- 1.0) × 0.34, if 160<ts≤ 220 or 0.80<ksd-m-0≤ 0.88, then a6= (c6-1.0)×0.67；
As 1.0≤ks-m-toe-ear≤ 1.08, then c6=ks-m-toe-ear- 1.0, if now ts>220 and ksd-m-0>0.88, then a6=c6If, ts≤ 160 or ksd-m-0≤ 0.80, then a6=c6× 0.34, if 160<ts≤ 220 or 0.80<ksd-m-0≤ 0.88, then a6=c6×0.67；
Wherein,
Preferably, the 7th correcting variable a7It is calculated by below equation：
If kts-toe-ear<1.0, then a7=0；
Work as kts-toe-ear>1.08, then c7=1.08, now, if ts>220 and ksd-m-0>0.88, then a7=c7- 1.0, if ts< 160 or ksd-m-0<0.80, then a7=(c7- 1.0) × 0.34, if 160<ts≤ 220 or 0.80<ksd-m-0≤ 0.88, then a7=(c7- 1.0)×0.67；
As 1.0≤kts-toe-ear≤ 1.08, then c7=kts-toe-ear- 1.0, now, if ts>220 and ksd-m-0>0.88, Then a7=c7If, ts≤ 160 or ksd-m-0≤ 0.80, then a7=c7× 0.34, if 160<ts≤ 220 or 0.80<ksd-m-0≤ 0.88, Then a7=c7×0.67；
Wherein,
As shown from the above technical solution, the correction side of the pulse wave propagation time related to systolic pressure that the present invention is provided Method, by ear pulse wave and toe pulse wave under the same cardiac cycle of real-time detection, calculates the arteries and veins related to systolic pressure Fight wave propagation time, and the morphological feature extraction correcting variable according to pulse wave, obtain correction matrix, above-mentioned pulse wave is propagated The mutation of time carries out self adaptive correction, and the propagation time after correction can be used for existing mathematical model, connect in the clinical setting Continue, accurately measure the systolic pressure of each cardiac cycle.
Specific embodiment
The embodiment of technical solution of the present invention will be described in detail below.Following examples are only used for clearer Ground explanation technical scheme, therefore example is intended only as, and can not be limited the scope of the invention with this.
The change of peri-operation period PTT can be divided into two classes.One class changes：The PTT changes that blood pressure causes；Two classes change： PTT and the nonsynchronous change of blood pressure (both change directions or variable quantity be not accordant to the old routine function rule).For example, blood volume is light PTT can increase when degree is not enough, but the regulation due to body itself to Peripheral resistance, and blood pressure may change less；In chest and abdomen operation PTT may be had a strong impact on using drag hook, but the impact to blood pressure is less；Norepinephrine makes small artery strong contraction, blood pressure Significantly raised but average on whole body PTT affects less.
When PTT occurs a class to be changed, it remains able to be expressed with determination function with the relation of blood pressure, can be by number Learn model to estimate the change of blood pressure.And when PTT occur two classes change when, using be based on regular circulation system mathematical model come Estimation blood pressure can produce larger error.This kind of error is the original reason error that blood pressure is measured using PTT, it is impossible to by initial fixed Mark with periodic calibration mathematical model parameter to solve.The difference of PTT and same individual PTT mutations are property between Different Individual Two different class problems, need to be solved with different methods.For this purpose, the present invention extracts various according to the metamorphosis of pulse wave Variable carrys out the various two classes change of indirect identification and adaptively correcting PTT, overcomes above-mentioned original reason error；Can be with reference to existing number Learn model and formed and possess the method that the continuous non-invasive of adaptive calibration function measures blood pressure, it is not necessary to by conventional method such as cuff Oscillographic method calibrating repeatedly.
The preferred ear of position of human body and toe of detection pulse wave, the pulse wave at the two positions can obtain large artery trunks and The physiology of peripheral arterial, pathological information, possess representativeness in route of transmission.The preferred infrared light of sensor of detection pulse signal Power Capacity recording instrument (PPG).The relative change of form between ear and the metamorphosis and two kinds of pulse waves of toe pulse wave itself Change, the change of the difference of the change of two classes and human body different parts blood pressure to recognizing PTT provides abundant information.The present invention goes through When a large amount of operation cases of several years collection the pulse wave and PTT of invasive arteriotony, ear and toe be analyzed, according to Two pulse waves itself and relative metamorphosis extract various variables, work out different variables two classes different from PTT and become Relation between change, and define the scope of application of various variables.
During clinical practice, using PPT continuous blood pressure measurings during, in real time analysis pulse wave simultaneously extracts variable, root Judge whether PTT occurs the change of two classes according to whether variable falls into the scope of application, and the classes of PTT bis- are determined according to the property for being suitable for variable The nature and extent of change, if certain variable does not occur corresponding two classes change, the change beyond scope of application explanation PTT Amount is inapplicable；Applicable several variables are merged, correcting value is calculated and PTT is corrected, the PTT/PWV after correction is fitted Blood pressure is accurately calculated for existing mathematical model.
The present invention expresses main, the most basic Changing Pattern of pulse wave form using limited variable, and works out Relation between these rules and PTT.Described below pulse wave vertical coordinate on plane coordinates is amplitude h, and abscissa is the time T, pulse wave starting point is zero.
Embodiment：
The bearing calibration of the pulse wave propagation time related to systolic pressure, comprises the following steps：
S1) pulse wave and analysis obtains the data below of ear pulse wave at ear under each cardiac cycle of real-time detection： The height h of aortic valve closing point on ear pulse wavesd, i.e., the intersection that systole is presented with relaxing period on ear pulse wave Highly, the systole time t of ear pulse waves, unit is millisecond, the relaxing period time t of ear pulse waved, unit is millisecond, Maximum height h of ear pulse wavemax；
S2) pulse wave and analysis obtains the data below of toe pulse wave at toe under each cardiac cycle of real-time detection： The systole time t of toe pulse waves-toe, unit is millisecond, the relaxing period time t of toe pulse waved-toe, unit is millisecond, Maximum height h of toe pulse wavemax-toe, the time t of the starting point of toe pulse wave to crest midpointch-toe, unit is in the least Second, time t of the starting point to crest peak in toe pulse wavemax-toe, unit is millisecond；The crest midpoint refers to crest The rising edge turning point at place and the midpoint of trailing edge turning point；The definition at crest midpoint refers to document YAN CHEN, CHANGYUN WEN,GUOCAI TAO,and MIN BI《Continuous and Noninvasive Measurement of Systolic and Diastolic Blood Pressure by One Mathematical Model with the Same Model Parameters and Two Separate Pulse Wave Velocities》Understand.
S3) the pulse wave propagation time T related to systolic pressure is calculateds, its definition refers to document YAN CHEN, CHANGYUN WEN,GUOCAI TAO,and MIN BI《Continuous and Noninvasive Measurement of Systolic and Diastolic Blood Pressure by One Mathematical Model with the Same Model Parameters and Two Separate Pulse Wave Velocities》Understand；H be ear pulse wave or Amplitude of the toe pulse wave on y direction；
S4) using the data obtained by step S1, S2 under same cardiac cycle, it is calculated school under the cardiac cycle Positive variable；
S5) according to the correcting variable under the cardiac cycle of step S4 acquisition, it is calculated under the cardiac cycle and corrects square Battle array；
S6 the correction matrix under multiple cardiac cycles) is continuously obtained, to the T obtained by step S3sIt is corrected.
The method can be under the same cardiac cycle of real-time detection ear pulse wave and toe pulse wave, calculate and shrink The related pulse wave propagation time of pressure, and the morphological feature extraction correcting variable according to pulse wave, acquisition correction matrix, to above-mentioned The mutation of pulse wave propagation time is corrected, and the propagation time after correction can be used for existing mathematical model, in clinical condition The systolic pressure of each cardiac cycle is continuously measured down.
First correcting variable a1：
The correcting variable obtained in step S4 includes the first correcting variable a1, a1For hypotension state correction and receipts The related propagation time T of contractive pressuresTwo classes change, a1The scope of application be a1>0, a1It is more big then to indicate that blood pressure is lower.
ksd-m-0Represent hsdWith the ratio of ear pulse wave systole average height.A part of case exists During hypotension state, pulse wave crest is presented the triangle for turning forward.hsdReduce a lot, ksd-m-0Diminish, illustrate that aorta shrinks End of term section waveform reduces a lot, and the continuous driving force for promoting pulse wave to propagate is not enough, and the propagation time extends.In the diastole of this state Phase information is unstable, should not use.d1=76～84, preferably 80；d1-2=104～112, preferably 108.
When the continuous driving force for promoting pulse wave to propagate is not enough, propagation time TsExtend, need a1Correction.Even d1≤ ksd-m-0≤d1-2, then a1=(d1-2-ksd-m-0)×0.50；
When the continuous driving force wretched insufficiency for promoting pulse wave to propagate, propagation time TsExtend a lot, a1Capping value comes school Just.Even ksd-m-0<d1, then a1=28 × 0.50；
When the continuous driving force for promoting pulse wave to propagate is sufficient, it is not necessary to correct Ts, a1It is inapplicable.Even ksd-m-0>d1-2, Then a1=0.
Second correcting variable a2：
The correcting variable obtained in step S4 also includes the second correcting variable a2, a2For hypertensive state and from Normal arterial pressure state corrects the pulse wave propagation time T related to systolic pressure to the change procedure of hypertensive statesTwo classes become Change, a2The scope of application be a2>0, a2It is more big, show that systolic pressure is higher.
ksd-m-tsRepresent hsdWith ear pulse wave relaxing period ts-2tsThe ratio of section average height, uses In the variation for judging pulse wave relaxing period.For example, upper drag hook causes aorta stress to change in chest and abdomen operation, makes ear pulse wave The waveform of relaxing period is reduced, ksd-m-tsBecome big.
ksd-m-2Represent hsdWith ear pulse wave 0-2tsThe ratio of section average height, contains contraction Phase and the shape information of part relaxing period, are mainly used in hypertensive state and the change from normal arterial pressure state to hypertensive state Change process, such as tracheal intubation cause heart rate and blood pressure to raise.In change procedure from normal arterial pressure state to hypertensive state, ear The crest of piece pulse wave is gradually presented the triangle of equilateral triangle or hypsokinesis, hsdGradually rise, ksd-m-2Become larger；In high blood Under pressure condition, whole ear pulse wave is all presented the triangle of equilateral triangle or hypsokinesis, hsdRise much higher, ksd-m-2Become very big； Apex (i.e. maximal blood pressure) persistent period of above two waveform is all very short, and corresponding with maximal blood pressure persistently moves Power is not enough, propagation time TsIt is relative to extend.
If | ksd-m-0-ksd-m-ts| >=40 and (ksd-m-0+ksd-m-ts)/2≥ksd-m-2,
Then ksd-m=2 × ksd-m-2-(ksd-m-0+ksd-m-ts)/2,
Otherwise ksd-m=ksd-m-2；
If the waveform variations of ear pulse wave relaxing period, for example, the upper drag hook of chest and abdomen operation causes aorta stress to change, arteries and veins There are significant changes in the form of ripple relaxing period of fighting, then to ksd-mIt is corrected, otherwise ksd-m=ksd-m-2。d2=1.17～1.27, Preferably 1.22.
If ksd-m>(d2+ (age-14)/15/100), wherein age is the age, and age >=14 year old indicate whole ear pulse wave Or its crest is changed into the triangle of equilateral triangle or hypsokinesis, the continuous driving force corresponding with maximal blood pressure is not enough, propagation time Ts It is relative to extend, need a2To correct, then a2=ksd-m-(d2+(age-14)/15/100)。
If ksd-m≤(d2+ (age-14)/15/100), pulse wave wave crest portions are gentle, and corresponding with maximal blood pressure continues Power is sufficient, it is not necessary to a2To correct, then a is made2=0.
3rd correcting variable a3：
The correcting variable obtained in step S4 also includes the 3rd correcting variable a3, a3For changing or passing in blood volume To T in the state of sensor installation site Temperature changingsIt is corrected.
For ear pulse wave relaxing period average height and maximum height hmaxRatio. Patient's fasting and blood volume is reduced when drinking water less before surgery,Reduce, pulse wave propagation time extends, when defeated in operation When blood transfusion causes blood volume to increase,Increase, the propagation time shortens.
If ksd-m-ts≤d3-2, indicate the waveform rising of ear pulse wave diastole early stage and surmount normal range, it is right to needIt is modified, correction result is designated as
IfCan determine whether out ear pulse Ripple is interfered, thend3=0.02～0.14, preferably 0.08；d3-2=1.21～1.31, preferably 1.26。
For toe pulse wave relaxing period average height and maximum height hmax-toeRatio, ts-toeRepresent the paradoxical expansion time recognized on toe pulse wave, td-toeRepresent and recognized on toe pulse wave The relaxing period time.IfThenWithEffect it is identical with property.
Two variables of ear and toe pulse wave property identical are closed And, its meansigma methods is taken as calibration TsVariable；If the waveform of pulse wave relaxing period morphs, to kd-m-aIt is corrected.
If | ksd-m-0-ksd-m-ts| >=40 and (ksd-m-0+ksd-m-ts)/2≥ksd-m-2And ksd-m-ts≥d3-2,
Then
Blood volume is normal and sensor installation site body temperature also normal state, a3It is inapplicable.Even c4<kd-m-a< c5, then a is made3=0.c4=(d4+ (age-14)/8)/100, d4=23～35, preferably 29；c5=(d5+(age-14)/8)/ 100, d5=27～39, preferably 33.
In the very low or very high state of blood pressure, relaxing period information is unstable, a3It is inapplicable.Even ksd-m-0<d6Or ksd-m-2> d7, then a is made3=0.d6=0.97～1.03, preferably 1.00；d7=1.52～1.58, preferably 1.55.
In normal arterial pressure state, blood volume reduction or sensor installation site hypothermia, a3Take on the occasion of 67%.I.e. If ksd-m-0≥d6+ 0.10 and ksd-m-2≤d8And kd-m-a≤c4, then a3=(c4-kd-m-a)×67/100。d8=1.42～ 1.48, preferably 1.45.
In the relatively low or higher state of blood pressure, blood volume reduction or sensor installation site hypothermia, a3Take normal The 50% of blood pressure status values.EvenOrThen a3=(c4- kd-m-a)×50/100；
In normal arterial pressure state, when blood volume increases or sensor installation site body temperature is raised, a3Take the 62% of negative value.I.e. If ksd-m-0≥d6+ 0.10 and ksd-m-2≤d8And kd-m-a≥c5, then a3=(c5-kd-m-a)×62/100；
In the relatively low or higher state of blood pressure, when blood volume increases or sensor installation site body temperature is raised, a3Take normal The 45% of blood pressure state negative value.EvenOrThen a3=(c5- kd-m-a)×45/100。
4th correcting variable a4：
The correcting variable obtained in step S4 also includes the 4th correcting variable a4, a4In the case where periphery vasodilation causes In the case that limb blood pressure (relative to radial artery blood pressure) is reduced, to TsIt is corrected, a4The scope of application be a4>0, a4Bigger table Bright blood pressure of lower extremities relative to radial artery blood pressure drop is low must be more.
Peripheral vascular contraction and expansion can cause the crest of toe pulse wave position on a timeline to move forward and backward.If tmax-toe≥tch-toe, thenOtherwiseks-t-toeFor toe To the time of crest and the ratio of Syst time, 200 is adjustment factor to pulse wave starting point.Move after the peak of crest super Cross midpoint, i.e. tmax-toe≥tch-toeWhen, to ks-t-toeIt is corrected；ks-t-toeValue it is larger when, point out toe vasodilation, under Limb blood pressure is reduced.Even ks-t-toe>0.8, then a4=ks-t-toe-0.8.If ks-t-toe≤ 0.8, a4It is inapplicable, then make a4=0.
5th correcting variable a5；
The correcting variable obtained in step S4 also includes the 5th correcting variable a5, a5Effect and property and a4With phase Together, in the case where blood pressure of lower extremities is low relative to radial artery blood pressure drop to TsIt is corrected.
ks-m-toeFor toe pulse wave systole average height and maximum height hmax-toeIt Than；ks-m-toeRepresent that toe pulse wave crest is broad and gentle when very big, toe vasodilation is pointed out, relative to radial artery Speech blood pressure of lower extremities is being reduced, a5Effect and property and a4With identical.
When toe blood vessel is not expanded, a5It is inapplicable.Even ks-m-toe<d9, then a is made5=0.d9=0.67～0.73, preferably For 0.7.
When moving more than midpoint after the peak of toe vasodilation and pulse wave crest, a5Take on the occasion of.Even ks-m-toe≥d9 And ks-t-toe>=0.8, then a5=ks-m-toe-d9。
When toe vasodilation and the peak position of pulse wave crest are not above midpoint, a5Take on the occasion of halving.Even ks-m-toe≥d9And ks-t-toe<0.8, then a5=(ks-m-toe-d9)/2。
6th correcting variable a6；
The correcting variable obtained in step S4 also includes the 6th correcting variable a6, a6Represent two pulse wave areas Relative change, for toe vasodilation, blood pressure of lower extremities relative to radial artery blood pressure drop it is low when to TsIt is corrected.a6Be suitable for Scope is a6>0。
ks-m-toe-earFor the Syst face of toe pulse wave Product and the Syst area ratio of ear pulse wave, 100 is adjustment factor；ks-m-toe-earWith kts-toe-earEffect and property phase Together.
When toe corrugated product is less than ear corrugated product, toe blood vessel does not have relative distension, a6It is inapplicable.Even ks-m-toe-ear <1.0, then make a6=0.
Under the first prerequisite, toe area is many more than ear area, and toe vasodilation is more, c6Take constant 1.08 is standby as maximum.Even ks-m-toe-ear>1.08, then make c6=1.08.
If ear pulse wave form is normal, a6Take maximum correction.Even ts>220 and ksd-m-0>0.88, then a6=c6- 1.0。
If ear pulse wave occur it is very sharp lean forward triangle or waveform it is very narrow, represent ear pulse wave form Serious mutation, the now relative change between two pulse waves is exaggerated, needs to use calibration value reduction, a6Take most senior colonel The 1/3 of quasi- value.Even ts<160 or ksd-m-0<0.80, then a6=(c6-1.0)×0.34。
When ear pulse wave form mutation is less serious, a6Take the 2/3 of maximum correction.Even 160<ts≤ 220 or 0.80 <ksd-m-0≤ 0.88, then a6=(c6-1.0)×0.67。
Under second prerequisite, toe area is more than ear area, and the relative distension of toe blood vessel is less serious, c6Take Positive variable is standby.Even 1.0≤ks-m-toe-ear≤ 1.08, then c6=ks-m-toe-ear-1.0。
If ear pulse wave form is normal, a6Take positive variable and make corrected value.Even ts>220 and ksd-m-0>0.88, then a6 =c6。
If during the serious mutation of ear pulse wave form, the relative change between pulse wave is exaggerated, and needs to subtract calibration value It is little using, a6Take the 1/3 of positive variable.Even ts≤ 160 or ksd-m-0≤ 0.80, then a6=c6×0.34。
If during the less serious mutation of ear pulse wave, a6Take the 2/3 of positive variable, even 160<ts≤ 220 or 0.80< ksd-m-0≤ 0.88, then a6=c6×0.67。
7th correcting variable a7；
The correcting variable obtained in step S4 also includes the 7th correcting variable a7, a7Effect and property and a6With phase Together, a7Represent the relative change of two pulse wave systole width (systole time).
kts-toe-earFor the time of the paradoxical expansion of identification and ear on toe pulse wave The ratio of the Syst time recognized on pulse wave, 825 is adjustment factor；kts-toe-earIncrease prompting toe vasodilation, under Limb blood pressure is pressed in reduction relative to radial artery blood.
When toe blood vessel does not have relative distension, a7It is inapplicable.Even kts-toe-ear<1.0, then make a7=0.
Under the first prerequisite, when toe blood vessel relative distension is more, c7Take constant 1.08 standby as maximum. Even kts-toe-ear>1.08, then make c7=1.08.
If ear pulse wave form is normal, a7Take maximum correction.Even ts>220 and ksd-m-0>0.88, then a7=c7- 1.0。
If ear pulse wave form seriously becomes the different time, the relative change between pulse wave is exaggerated, and needs to subtract calibration value It is little using, a7Take the 1/3 of maximum correction.Even ts<160 or ksd-m-0<0.80, then a7=(c7-1.0)×0.34。
If ear pulse wave morphological variation is less serious, a7Take the 2/3 of maximum correction.Even 160<ts≤ 220 or 0.80<ksd-m-0≤ 0.88, then a7=(c7-1.0)×0.67。
Under second prerequisite, when toe width is more than ear widths, the relative distension of toe blood vessel is less serious, c7 Take positive variable standby.Even 1.0≤kts-toe-ear≤ 1.08, then c7=kts-toe-ear-1.0。
If ear pulse wave form is normal, a7Take positive variable and make corrected value.Even ts>220 and ksd-m-0>0.88, then a7 =c7。
If ear pulse wave form seriously makes a variation, a7Take the 1/3 of positive variable.Even ts≤ 160 or ksd-m-0≤ 0.80, then a7 =c7×0.34。
If the variation of ear pulse wave form is less serious, a7Take the 2/3 of positive variable.Even 160<ts≤ 220 or 0.80< ksd-m-0≤ 0.88, then a7=c7×0.67。
Correction matrix in step S5If wherein there is ai=0 represents aiIt is inapplicable.Step S6 Specially：The correction matrix under 8 cardiac cycles is continuously acquired, with the meansigma methodss of the variable of 8 cardiac cycles breathing is overcome The interference of fluctuation, 8 variables are chosen using recursion mode, often calculate a newest variable and just eliminate an oldest variable.School Correction method is：Tsma=Tsm(1-Am)；Wherein,AiFor under i-th cardiac cycle Correction matrix, TsiFor the T under i-th cardiac cycles。
Finally it should be noted that：Various embodiments above only to illustrate technical scheme, rather than a limitation；To the greatest extent Pipe has been described in detail with reference to foregoing embodiments to the present invention, it will be understood by those within the art that：Its according to So the technical scheme described in foregoing embodiments can be modified, either which part or all technical characteristic are entered Row equivalent；And these modifications or replacement, do not make the essence disengaging various embodiments of the present invention technology of appropriate technical solution The scope of scheme, it all should cover in the middle of the claim of the present invention and the scope of description.

Claims (10)

1. the bearing calibration of the pulse wave propagation time related to systolic pressure, it is characterised in that comprise the following steps：
S1) pulse wave and analysis obtains the data below of ear pulse wave at ear under each cardiac cycle of real-time detection：Ear The height h of aortic valve closing point on pulse wavesd, the systole time t of ear pulse waves, unit is millisecond, ear pulse wave Relaxing period time td, unit is millisecond, maximum height h of ear pulse wavemax；
S2) pulse wave and analysis obtains the data below of toe pulse wave at toe under each cardiac cycle of real-time detection：Toe The systole time t of pulse waves-toe, unit is millisecond, the relaxing period time t of toe pulse waved-toe, unit is millisecond, toe Maximum height h of pulse wavemax-toe, the time t of the starting point of toe pulse wave to crest midpointch-toe, unit is millisecond, foot Time t of the starting point of toe pulse wave to crest peakmax-toe, unit is millisecond；The crest midpoint is referred at crest The midpoint of rising edge turning point and trailing edge turning point；
S3) the pulse wave propagation time T related to systolic pressure is calculateds, the TsRefer to the aortic valve closing on ear pulse wave Time difference of the point to the aortic valve closing point on toe pulse wave；H is ear pulse wave or toe pulse wave in y direction On amplitude；
S4) using the data obtained by step S1, S2 under same cardiac cycle, it is calculated correction under the cardiac cycle and becomes Amount；
S5) according to the correcting variable under the cardiac cycle of step S4 acquisition, it is calculated correction matrix under the cardiac cycle；
S6 the correction matrix under multiple cardiac cycles) is continuously obtained, to the T obtained by step S3sIt is corrected；.
2. the bearing calibration of the pulse wave propagation time related to systolic pressure according to claim 1, it is characterised in that institute State the correction matrix in step S5aiFor the i-th correcting variable in correcting variable.
3. the bearing calibration of the pulse wave propagation time related to systolic pressure according to claim 1, it is characterised in that institute State step S6 to be specially：Continuously acquire the correction matrix under 8 cardiac cycles；Bearing calibration is：Tsma=Tsm(1-Am)；Wherein,AiFor the correction matrix under i-th cardiac cycle, TsiFor i-th cardiac cycle Under Ts。
4. the bearing calibration of the pulse wave propagation time related to systolic pressure according to claim 1, it is characterised in that institute State the first correcting variable a1It is calculated by below equation：
If d1≤ksd-m-0≤d1-2, then a1=(d1-2-ksd-m-0)×0.50；
If ksd-m-0<d1, then a1=28 × 0.50；
If ksd-m-0>d1-2, then a1=0；
Wherein,d1=76～84, d1-2=104～112.
5. the bearing calibration of the pulse wave propagation time related to systolic pressure according to claim 1, it is characterised in that institute State the second correcting variable a2It is calculated by below equation：
If ksd-m>(d2+ (age-14)/15/100), then a2=ksd-m-(d2+(age-14)/15/100)；
If ksd-m≤(d2+ (age-14)/15/100), then a2=0；
Wherein, if | ksd-m-0-ksd-m-ts| >=40 and (ksd-m-0+ksd-m-ts)/2≥ksd-m-2, then ksd-m=2 × ksd-m-2-(ksd-m-0 +ksd-m-ts)/2, otherwise ksd-m=ksd-m-2；
Age is the age, d2=1.17～1.27.
6. the bearing calibration of the pulse wave propagation time related to systolic pressure according to claim 1, it is characterised in that institute State the 3rd correcting variable a3It is calculated by below equation：
If c4<kd-m-a<c5, then a3=0；
If ksd-m-0<d6Or ksd-m-2>d7, then a3=0；
If ksd-m-0≥d6+ 0.10 and ksd-m-2≤d8And kd-m-a≤c4, then a3=(c4-kd-m-a)×67/100；
IfOrThen a3=(c4-kd-m-a)×50/100；
If ksd-m-0≥d6+ 0.10 and ksd-m-2≤d8And kd-m-a≥c5, then a3=(c5-kd-m-a)×62/100；
IfOrThen a3=(c5-kd-m-a)×45/100；
Wherein, if | ksd-m-0-ksd-m-ts| >=40 and (ksd-m-0+ksd-m-ts)/2≥ksd-m-2And ksd-m-ts≥d3-2, thenOtherwise
If ksd-m-ts≤d3-2, thenIf ThenIfThen c4=(d4+ (age-14)/8)/100, d4=23～35, c5=(d5+ (age-14)/8)/100, d5=27～39, d6=0.97～1.03, d7 =1.52～1.58, d8=1.42～1.48, d3-2=1.21～1.31, d3=0.02～0.14, age are the age.
7. the bearing calibration of the pulse wave propagation time related to systolic pressure according to claim 1, it is characterised in that institute State the 4th correcting variable a4It is calculated by below equation：If ks-t-toe>0.8, then a4=ks-t-toe-0.8；
If ks-t-toe≤ 0.8, then a4=0；
Wherein, if tmax-toe≥tch-toe, thenOtherwise
8. the bearing calibration of the pulse wave propagation time related to systolic pressure according to claim 1, it is characterised in that institute State the 5th correcting variable a5It is calculated by below equation：
If ks-m-toe<d9, then a5=0；
If ks-m-toe≥d9And ks-t-toe>=0.8 a5=ks-m-toe-d9；
If ks-m-toe≥d9And ks-t-toe<0.8, then a5=(ks-m-toe-d9)/2；
Wherein, d9=0.67～0.73,
9. the bearing calibration of the pulse wave propagation time related to systolic pressure according to claim 1, it is characterised in that institute State the 6th correcting variable a6It is calculated by below equation：
If ks-m-toe-ear<1.0, then a6=0；
Work as ks-m-toe-ear>1.08, then c6=1.08, now, if ts>220 and ksd-m-0>0.88, then a6=c6- 1.0, if ts<160 Or ksd-m-0<0.80, then a6=(c6- 1.0) × 0.34, if 160<ts≤ 220 or 0.80<ksd-m-0≤ 0.88, then a6=(c6- 1.0)×0.67；
As 1.0≤ks-m-toe-ear≤ 1.08, then c6=ks-m-toe-ear- 1.0, if now ts>220 and ksd-m-0>0.88, then a6= c6If, ts≤ 160 or ksd-m-0≤ 0.80, then a6=c6× 0.34, if 160<ts≤ 220 or 0.80<ksd-m-0≤ 0.88, then a6= c6×0.67；
Wherein,
10. the bearing calibration of the pulse wave propagation time related to systolic pressure according to claim 1, it is characterised in that 7th correcting variable a7It is calculated by below equation：
If kts-toe-ear<1.0, then a7=0；
Work as kts-toe-ear>1.08, then c7=1.08, now, if ts>220 and ksd-m-0>0.88, then a7=c7- 1.0, if ts<160 Or ksd-m-0<0.80, then a7=(c7- 1.0) × 0.34, if 160<ts≤ 220 or 0.80<ksd-m-0≤ 0.88, then a7=(c7- 1.0)×0.67；
As 1.0≤kts-toe-ear≤ 1.08, then c7=kts-toe-ear- 1.0, now, if ts>220 and ksd-m-0>0.88, then a7= c7If, ts≤ 160 or ksd-m-0≤ 0.80, then a7=c7× 0.34, if 160<ts≤ 220 or 0.80<ksd-m-0≤ 0.88, then a7= c7×0.67；
Wherein,
CN201611045054.5A 2016-11-22 2016-11-22 The bearing calibration of the pulse wave propagation time related to systolic pressure Active CN106580303B (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN201611045054.5A CN106580303B (en) 2016-11-22 2016-11-22 The bearing calibration of the pulse wave propagation time related to systolic pressure
PCT/CN2017/098155 WO2018095083A1 (en) 2016-11-22 2017-08-18 Pulse wave propagation time correction method
JP2019541843A JP6736110B2 (en) 2016-11-22 2017-11-20 Method of correcting pulse wave transit time for arterial blood pressure
EP17874481.9A EP3545832B1 (en) 2016-11-22 2017-11-20 Correction method for pulse wave propagation time related to diastolic blood pressure and systolic blood pressure
PCT/CN2017/111799 WO2018095291A1 (en) 2016-11-22 2017-11-20 Correction method for pulse wave propagation time related to diastolic blood pressure and systolic blood pressure
US16/391,287 US20190246919A1 (en) 2016-11-22 2019-04-22 Method and system for correcting pulse transit time associated with arterial blood pressure or blood pressure value calculated by pulse transit time
US17/874,618 US20220378307A1 (en) 2016-11-22 2022-07-27 Method for correcting pulse wavetransit time associated with diastolic blood pressure or systolic blood pressure

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201611045054.5A CN106580303B (en) 2016-11-22 2016-11-22 The bearing calibration of the pulse wave propagation time related to systolic pressure

Publications (2)

Publication Number Publication Date
CN106580303A true CN106580303A (en) 2017-04-26
CN106580303B CN106580303B (en) 2018-03-06

Family

ID=58592985

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201611045054.5A Active CN106580303B (en) 2016-11-22 2016-11-22 The bearing calibration of the pulse wave propagation time related to systolic pressure

Country Status (1)

Country Link
CN (1) CN106580303B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018095291A1 (en) * 2016-11-22 2018-05-31 浙江脉联医疗设备有限公司 Correction method for pulse wave propagation time related to diastolic blood pressure and systolic blood pressure
CN108784676A (en) * 2018-06-20 2018-11-13 博动医学影像科技（上海）有限公司 The method and device of pressure difference is obtained based on age information
CN108523867B (en) * 2018-03-28 2020-12-29 武汉麦咚健康科技有限公司 Self-calibration PPG non-invasive blood pressure measurement method and system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0443267A1 (en) * 1990-02-23 1991-08-28 Sentinel Monitoring, Inc. Method and apparatus for continuous non-invasive blood pressure monitoring
CN102008296A (en) * 2010-12-24 2011-04-13 吉林大学 Device and method for measuring arterial blood pressures based on pulse wave signals and electrocardiosignals
CN102258364A (en) * 2010-05-31 2011-11-30 深圳市盛力康实业发展有限公司 Pulse wave identification method, system and artery function detection instrument
CN103385702A (en) * 2013-07-26 2013-11-13 中国科学院深圳先进技术研究院 Non-invasive blood pressure continuous detection device and method
CN104382571A (en) * 2014-10-28 2015-03-04 李久朝 Method and device for measuring blood pressure upon radial artery pulse wave conduction time

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0443267A1 (en) * 1990-02-23 1991-08-28 Sentinel Monitoring, Inc. Method and apparatus for continuous non-invasive blood pressure monitoring
CN102258364A (en) * 2010-05-31 2011-11-30 深圳市盛力康实业发展有限公司 Pulse wave identification method, system and artery function detection instrument
CN102008296A (en) * 2010-12-24 2011-04-13 吉林大学 Device and method for measuring arterial blood pressures based on pulse wave signals and electrocardiosignals
CN103385702A (en) * 2013-07-26 2013-11-13 中国科学院深圳先进技术研究院 Non-invasive blood pressure continuous detection device and method
CN104382571A (en) * 2014-10-28 2015-03-04 李久朝 Method and device for measuring blood pressure upon radial artery pulse wave conduction time

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018095291A1 (en) * 2016-11-22 2018-05-31 浙江脉联医疗设备有限公司 Correction method for pulse wave propagation time related to diastolic blood pressure and systolic blood pressure
WO2018095083A1 (en) * 2016-11-22 2018-05-31 浙江脉联医疗设备有限公司 Pulse wave propagation time correction method
CN108523867B (en) * 2018-03-28 2020-12-29 武汉麦咚健康科技有限公司 Self-calibration PPG non-invasive blood pressure measurement method and system
CN108784676A (en) * 2018-06-20 2018-11-13 博动医学影像科技（上海）有限公司 The method and device of pressure difference is obtained based on age information

Also Published As

Publication number Publication date
CN106580303B (en) 2018-03-06

Similar Documents

Publication Publication Date Title
US9204857B2 (en) System and method for monitoring hemodynamic state
EP3545832B1 (en) Correction method for pulse wave propagation time related to diastolic blood pressure and systolic blood pressure
US20210022624A1 (en) Multifunctional measuring device capable of determining carotid blood pressure
EP2759257B1 (en) Method, logic unit and system for determining a parameter representative for the patient&#39;s volume responsiveness
DK2437654T3 (en) Hemodynamic data evaluation
US20080183232A1 (en) Method and system for determining cardiac function
EP3220812A2 (en) Pulse wave velocity, arterial compliance, and blood pressure
US20120157791A1 (en) Adaptive time domain filtering for improved blood pressure estimation
JP2020028726A (en) Apparatus and methods for computing cardiac output of living subject via applanation tonometry
CN106618504A (en) High-accuracy continuous non-invasive blood pressure measuring device with self-adaptation calibration function
WO2012021765A2 (en) Methods and apparatus for determining arterial pulse wave velocity
KR20190048878A (en) Method and apparatus for measuring blood pressure using optical sensor
CA3122115C (en) Method of predicting fluid responsiveness in patients
CN106580303A (en) Method for correcting systolic pressure-related pulse wave propagation time
US20230210492A1 (en) Hemodynamii parameter estimation
WO2017199174A1 (en) Non-invasive system and method for measuring blood pressure variability
Agham et al. Prevalent approach of learning based cuffless blood pressure measurement system for continuous health-care monitoring
CN106377238A (en) Correcting method for pulse wave propagation time related to diastolic pressure
Park et al. Cuffless and noninvasive tonometry mean arterial pressure measurement by physiological characteristics and applied pressure
US20230293035A1 (en) Cardiac Cycle Analysis Method and System
US20220361761A1 (en) Method, a device, and a system for estimating a measure of cardiovascular health of a subject
Halvorsen et al. Ali Wajdan1, 2, Magnus Reinsfelt Krogh1, 2, Manuel Villegas‑Martinez1, 3
Langewouters Blog# 7:“Why to Choose the Volume Clamp Method for cNIBP over Other Methods”
Langewouters Volume clamp method
Gupta Blood Pressure Monitoring

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant