CN106483338A

CN106483338A - Image output device, picture transmitter device, image received device, image output method

Info

Publication number: CN106483338A
Application number: CN201610644318.2A
Authority: CN
Inventors: 佐藤太; 佐藤太一; 本村秀人; 泽田好秀
Original assignee: Panasonic Intellectual Property Management Co Ltd
Current assignee: Panasonic Intellectual Property Management Co Ltd
Priority date: 2015-08-28
Filing date: 2016-08-09
Publication date: 2017-03-08
Also published as: JP6719104B2; JP2017046340A

Abstract

The disclosure provides a kind of image output device, picture transmitter device, image received device, image output method.Image output device (1001) possesses：Obtain the image acquiring unit (1101) of first resolution image；Obtain the high-definition picture acquisition unit (1102) of the second resolution image as the high image of resolution ratio first resolution image；Accept the amplification receiving unit (1201) of amplification；Whether high than the predetermined value detection unit (1202) of the evaluation of estimate based on the amplification being accepted for the judgement；And sending part (1204), be judged to evaluation of estimate than predetermined value high in the case of, send second resolution image, be judged to evaluation of estimate unlike predetermined value height in the case of, do not send second resolution image.

Description

Image output device, picture transmitter device, image received device, image output method

Technical field

It relates to image output device, picture transmitter device and image received device etc..

Background technology

In the past, employed optical microscope for the micro-structure observed in bio-tissue etc..Optical microscope utilizes Through the light after the light after the object of observation or reflection.Observer observes the picture after amplifying using lens.It is known that to by showing The digit microscope shown in being shot and carry out over the display after the lens amplification of micro mirror.By using digital micrograph Mirror, be capable of many people observe simultaneously, long-range observation etc..

In recent years, using CIS (Contact Image Sensing；Contact type image senses) mode observes micro-structure Technology attracts attention.In the case of based on CIS mode, the object of observation is closely configured with the shooting face of imageing sensor.Make For imageing sensor, generally use a large amount of photoelectric conversion parts be arranged in rows in shooting face and column-shaped two dimensional image sensing Device.Photoelectric conversion part is typically formed at the photodiode of semiconductor layer or semiconductor substrate, accepts incident illumination and gives birth to Become electric charge.

The image being obtained by imageing sensor is specified by a large amount of pixels.Each pixel is by comprising 1 photoelectric conversion part Unit area is dividing.Therefore, the resolution capability (resolution) of two-dimensional image sensor often relies on the photoelectricity on shooting face The arrangement pitches (pitch) of converter section.In this manual, the resolution energy that sometimes will be determined by the arrangement pitches of photoelectric conversion part Power is referred to as " the intrinsic resolution ability " of imageing sensor.Because the arrangement pitches of each photoelectric conversion part are as short as the wavelength of visible ray Left and right, accordingly, it is difficult to improve intrinsic resolution ability further.

Have been presented for achieving over the skill of the resolution capability (that is, high-resolution) of the intrinsic resolution ability of imageing sensor Art.Patent document 1 discloses that following technology：Formed using the multiple images obtained by image space movement making subject The image (that is, high-resolution image) of this subject.

Prior art literature

Patent documentation 1：Japanese Unexamined Patent Application 62-137037 publication

Content of the invention

But, there are the following problems：The data volume of high-resolution image is big, the transmission reception of this image or preservation etc. Processing load weight.

Illustrate in non-limiting manner mode of the disclosure is：Can mitigate high-definition picture transmission receive or The image output device of the burden of process, picture transmitter device and the image received devices such as preservation.One mode of the disclosure The benefit of additivity and advantage point according to this specification and accompanying drawing Lai clearly.This benefit and/or advantage point can pass through Various modes disclosed in this specification and accompanying drawing and feature being provided separately, are not configured to obtain it more than one Benefit and/or advantage point and be all necessary.

The image output device involved by one mode of the disclosure, possesses：At least one processor；With holding order Non-transitory recording medium, described order makes at least one computing device described：Acquisition first resolution image, described first Resolution chart seems the image based on subject obtained from the shooting of digit microscope；Obtain second resolution image, Described second resolution image is that first resolution image described in resolution ratio is high, the shooting based on described digit microscope and The image of the described subject obtaining；Accept the amplification for the described first resolution image shown by display device Rate；Judge whether the evaluation of estimate based on the described amplification being accepted is higher than predetermined value；Being judged to, evaluation values are than described In the case of predetermined value height, send described second resolution image to external device (ED), evaluation values are unlike described being judged to In the case of predetermined value height, do not send described second resolution image to described external device (ED).

Additionally, these master or specific modes both can pass through system, method, integrated circuit, computer program Or computer-readable recording medium is realized it is also possible to pass through system, method, integrated circuit, computer program or record The arbitrary combination of medium is realizing.Computer-readable recording medium for example comprises CD-ROM (Compact Disc-Read Only Memory) etc. non-volatile recording medium.

According to the disclosure, can mitigate high-definition picture sends the burden process such as receiving or preserving.

Brief description

Fig. 1 is the pie graph of that illustrates to comprise the image processing system of the image output device in embodiment 1.

Fig. 2 is the figure of that illustrates the display picture being shown by display device in embodiment 1.

Fig. 3 is the flow chart of of the process work illustrating the image output device in embodiment 1.

Fig. 4 is the flow chart of the other examples of process work illustrating the image output device in embodiment 1.

Fig. 5 is the structure of that illustrates to comprise the image processing system of the image output device of the variation of embodiment 1 Cheng Tu.

Fig. 6 is the pie graph of that illustrates to comprise the image processing system of the image output device in embodiment 2.

Fig. 7 is the flow chart of the process work illustrating picture transmitter device and image received device in embodiment 2.

Fig. 8 is the structure of of the image processing system of the image output device of variation 1 illustrating to comprise embodiment 2 Cheng Tu.

Fig. 9 is to illustrate the picture transmitter device of variation 1 of embodiment 2 and the process work of image received device Flow chart.

Figure 10 is of the image processing system of the image output device of variation 2 illustrating to comprise embodiment 2 Pie graph.

Figure 11 is to illustrate to comprise the picture transmitter device of variation 2 of embodiment 2 and the process of image received device The flow chart of work.

Figure 12 is the pie graph of that illustrates to comprise the image processing system of the image output device in embodiment 3.

Figure 13 is illustrate to comprise the image processing system of the image output device of variation 1 in embodiment 3 one Pie graph.

Figure 14 is the other illustrating to comprise the image processing system of the image output device of variation 2 in embodiment 3 The pie graph of example.

Figure 15 A is the top view of the part schematically showing subject 2.

Figure 15 B is to extract and schematically illustrated the photodiode related to the shooting in the region shown in Figure 15 A Top view.

Figure 16 A is to schematically show through subject 2 to be incident to the direction of the light of photodiode 4p Sectional view.

Figure 16 B is to schematically show through subject 2 to be incident to the direction of the light of photodiode 4p Sectional view.

Figure 16 C is the figure schematically showing 6 pixels Pa being obtained by 6 photodiode 4p.

Figure 17 A is to schematically show to make light from the irradiation side different from the direction of illumination shown in Figure 16 A and Figure 16 B Sectional view to incident state.

Figure 17 B is to schematically show to make light from the irradiation side different from the direction of illumination shown in Figure 16 A and Figure 16 B Sectional view to incident state.

Figure 17 C is to be shown schematically in 6 pixels Pb obtain under the direction of illumination shown in Figure 17 A and Figure 17 B Figure.

Figure 18 A be schematically show make light from the direction of illumination shown in Figure 16 A and Figure 16 B and Figure 17 A with And the sectional view of the incident state of the different direction of illumination of the direction of illumination shown in Figure 17 B.

Figure 18 B be schematically show make light from the direction of illumination shown in Figure 16 A and Figure 16 B and Figure 17 A with And the sectional view of the incident state of the different direction of illumination of the direction of illumination shown in Figure 17 B.

Figure 18 C is to be shown schematically in 6 pixels Pc obtain under the direction of illumination shown in Figure 18 A and Figure 18 B Figure.

Figure 19 A be schematically show make light from the direction of illumination shown in Figure 16 A and Figure 16 B, Figure 17 A and figure Direction of illumination shown in 17B and the incident state of the different direction of illumination of the direction of illumination shown in Figure 18 A and Figure 18 B Sectional view.

Figure 19 B is the figure being shown schematically in 6 pixels Pd obtain under the direction of illumination shown in Figure 19 A.

Figure 20 is the figure illustrating the high resolution image HR by 4 subimage Sa, Sb, Sc and Sd synthesis.

Figure 21 is that the light in adjacent 2 region schematically showing and being adjusted to pass subject 2 enters respectively It is incident upon the sectional view of the direction of illumination of different photodiodes.

Figure 22 A is the figure of of the cross-sectional configuration schematically showing module.

Figure 22 B is the vertical view of that illustrates outward appearance when observing the module 10 shown in Figure 22 A from imageing sensor 4 side Figure.

Figure 23 is the figure of of the manufacture method for specification module.

Figure 24 A is the sectional view illustrating the example of irradiating angle when obtaining subimage.

Figure 24 B is the method illustrating to irradiate subject with the irradiating angle different from the irradiating angle shown in Figure 24 A Example sectional view.

Figure 25 is the skeleton diagram of of the composition of the image acquiring device illustrating embodiment of the present disclosure.

Figure 26 A is the axonometric chart of the exemplary outward appearance illustrating image acquiring device 100a.

Figure 26 B is the solid being shown in the state closing cap 120 in the image acquiring device 100a shown in Figure 26 A Figure.

Figure 26 C is the object stage 32 schematically showing socket (socket) 130 with respect to image acquiring device 100a The figure of of packing method.

Figure 27 A is the figure of that schematically shows the method changing direction of illumination.

Figure 27 B be schematically show make object stage 32 with respect to datum level tilt angle theta when, be incident to be taken right The figure of the change in the direction of the light of elephant.

Figure 28 is the distribution with subject relative absorbance Td for the cross-sectional configuration illustrating ccd image sensor The figure of example.

Figure 29 A is to illustrate the cross-sectional configuration of rear surface irradiation type cmos image sensor and subject relative transmission The figure of the example of the distribution of rate Td.

Figure 29 B is to illustrate the cross-sectional configuration of rear surface irradiation type cmos image sensor and subject relative transmission The figure of the example of the distribution of rate Td.

Figure 30 is to illustrate that the cross-sectional configuration of photoelectric conversion film cascade type imageing sensor is saturating with subject relative Penetrate the figure of the example of the distribution of rate Td.

Label declaration

100S, 100Sa, 200S, 200Sa, 200Sb image processing system；1001st, 1001a, 2001,2001a image output Device；1100th, 1100a, 1100b picture transmitter device；1101 image acquiring unit；1102 high-definition picture acquisition units；1103 Second output section；1200th, 1200a, 1200b image received device；1201 amplification receiving unit；1202 detection units；1203 displays are used Output section；1204th, 1204a sending part；1205 first output sections；1206 evaluation of estimate storage parts；1500 digit microscopes；1501 show Showing device；1502nd, 1503 recording medium

Specific embodiment

(becoming the opinion on the basis of the present invention)

The present inventor with regard to the high resolution described in " background technology " one hurdle technology it was found that there is following asking Topic.

In employing microscopical pathologic finding, according to each corpse or other object for laboratory examination and chemical testing (an also referred to as pathology corpse or other object for laboratory examination and chemical testing) becoming the object of observation Condition of illness, the multiplying power of the lens of use is also different.For example in the inspection of cancer, first, using 10 times, thing lens are seen Examine.Being the corpse or other object for laboratory examination and chemical testing in the high region of cancer for not there is a possibility that to suspect, only sight just being made by 10 times of the observation to thing lens Examine end, but be the high region of probability of cancer if there is suspecting, then object lens switch to 40 times of lens examined Look into.So, accordingly change power of a lens with a corpse or other object for laboratory examination and chemical testing.Due to high amplification cannot be determined the need for before being checked Rate, therefore, to carry out the shooting of a corpse or other object for laboratory examination and chemical testing from each amplification being determined in advance of high amplification to low amplification.

In the case of the image of a corpse or other object for laboratory examination and chemical testing being shot using digit microscope, the resolution of this image is higher, then clap Take the photograph the time and image size (size) is got over and increased.If big to the image of 10 times of thing by being equivalent to of obtaining of digit microscope Little for 100M byte, then the size being equivalent to the image to 40 times of thing is 1.6G byte.

Further it is necessary to the quantity of the pathology corpse or other object for laboratory examination and chemical testing being checked increases, and on the other hand, the increase of Pathology Doctors ' is but caught up with not The increase of the quantity of a upper pathology corpse or other object for laboratory examination and chemical testing.Therefore, from now on it is contemplated that being the long-range disease sending as the image being obtained by digit microscope Reason image, can be continuously increased by the situation that the Pathology Doctors ' being located at remotely carries out pathological diagnosis.In addition, overall with medical treatment Prosperityization it is difficult to be carried out the diagnosis of all of internal organs or symptom by a Pathology Doctors '.Therefore it may be desirable to remotely be examined Disconnected, the Pathology Doctors ' image of a corpse or other object for laboratory examination and chemical testing that is difficult to diagnose at scene will be sent to the pathology with Professional knowledge being located at remotely Doctor is being diagnosed.But, the transmission that there is high-resolution pathological image needs this problem of cost time.

In order to solve such problem, the image output device of a mode of the present invention possesses：Image acquiring unit, obtains First resolution image, described first resolution image is the figure based on subject obtained from the shooting of digit microscope Picture；High-definition picture acquisition unit, obtains second resolution image, described second resolution image is first described in resolution ratio The image of described subject obtained from resolution chart image height, the shooting based on described digit microscope；Amplification accepts Portion, accepts the amplification for the described first resolution image shown by display device；Detection unit, judges to be based on and is put by described Whether the evaluation of estimate of the described amplification that big receiving unit accepts is higher than predetermined value；And sending part, judged by described detection unit For institute's evaluation values higher than described predetermined value in the case of, to external device (ED) send described second resolution image, by described In the case that detection unit is judged to institute's evaluation values unlike described predetermined value height, do not send described second point to described external device (ED) Resolution image.

Thus, only in the case of evaluation of estimate height, send second resolution image.That is to say, can be sufficient only for having Diagnose a necessary corpse or other object for laboratory examination and chemical testing (subject), by the image of this corpse or other object for laboratory examination and chemical testing with high-resolution for example to remotely sending.Therefore, it is possible to Suppression is in order to send the high-definition picture of the low corpse or other object for laboratory examination and chemical testing of that importance degree that for example just can diagnose with the short time, and postpones Send and there is the sufficient high-definition picture diagnosing a necessary corpse or other object for laboratory examination and chemical testing.Further, since not carrying out the high score of the low corpse or other object for laboratory examination and chemical testing of evaluation of estimate The transmission of resolution image, therefore, it is possible to mitigate the burden of the process of high-definition picture.

In addition, by described detection unit, described sending part can also be judged to that institute's evaluation values are high unlike described predetermined value In the case of, send described first resolution image to described external device (ED).

Thus, the Pathology Doctors ' being for example located at remotely can be also the first resolution using the low-resolution image sending Rate image is carrying out the diagnosis of a corpse or other object for laboratory examination and chemical testing.

In addition, described image output device can also possess the first output section, this first output section is by described detection unit In the case of being judged to that institute's evaluation values are higher than described predetermined value, described second resolution image is exported and preserves to record Jie Matter, in the case of be judged to institute's evaluation values unlike described predetermined value height by described detection unit, not by described second resolution Image exports to described recording medium.

The image size of high-definition picture (second resolution image) is big, in pathologic finding, for the corpse or other object for laboratory examination and chemical testing checking Image preserved in units of 10 years.In addition, the technology obtaining a corpse or other object for laboratory examination and chemical testing from human body improves constantly now, a corpse or other object for laboratory examination and chemical testing for shooting Quantity should also can constantly rise from now on.Therefore, the image that photographed using digit microscope, particularly high resolution graphics The preservation of picture becomes important problem.

Then, in a mode of the present invention, only in the case of evaluation of estimate height, preserve second resolution image.Namely It is can to preserve the image of this corpse or other object for laboratory examination and chemical testing with high-resolution only to there being the necessary corpse or other object for laboratory examination and chemical testing of sufficient diagnosis (subject).Cause This, can be suppressed to preservation and for example can diagnose the high-definition picture of the low corpse or other object for laboratory examination and chemical testing of such importance degree with the short time, and understand Limit the idle capacity of recording medium.Further, since not carrying out the preservation of the high-definition picture of the low corpse or other object for laboratory examination and chemical testing of evaluation of estimate, because This, can mitigate the burden of the process of high-definition picture.

In addition, for example, described detection unit is by 1 accepted by described amplification receiving unit or multiple described amplification , maximum amplification to derive as institute's evaluation values.Or or the high amplification as the amplification higher than threshold value Rate by described amplify the number of times that accepts of receiving unit more or, the image of described subject is with described high amplification by institute State that the time that display device shows is longer, then described detection unit derives higher institute's evaluation values.Or or with than threshold The area of the described subject that the high described amplification of value is shown by described display device is bigger, then described detection unit calculates Higher institute's evaluation values.

Derive suitable evaluation of estimate thereby, it is possible to the purposes according to the image of subject, can only send and close most Suitable high-definition picture (second resolution image).

In addition, the image output device of the alternate manner of the present invention be with picture transmitter device and via communication line with The image output device of the image received device that described image dispensing device connects, described image dispensing device possesses：Image obtains Take portion, obtain first resolution image, described first resolution image is to be clapped based on obtained from the shooting of digit microscope Take the photograph the image of object；High-definition picture acquisition unit, obtains second resolution image, described second resolution image is resolution Higher than the described first resolution image, figure of described subject obtained from the shooting based on described digit microscope Picture；Whether detection unit, judge the evaluation of estimate representing by the evaluation of estimate related information being notified by described image reception device than pre- Definite value is high；And sending part, in the case of being judged to that by described detection unit institute's evaluation values are higher than described predetermined value, to described Image received device sends described second resolution image, is being judged to that institute's evaluation values are predetermined unlike described by described detection unit In the case of value height, send described first resolution image to described image reception device, described image reception device possesses：Put Big receiving unit, accepts the amplification for the described first resolution image shown by display device；With display output section, from Described image dispensing device obtains described first resolution image or described second resolution image, so that described display device is shown Show based on by the described described first resolution image or described second amplifying after the described amplification amplification that receiving unit accepts Image in different resolution, described display output section also sends to described image dispensing device amplifies what receiving unit accepted based on by described Institute's evaluation values related information of described amplification.

Or, the image output device of the alternate manner of the present invention be with picture transmitter device and via communication line with The image output device of the image received device that described image dispensing device connects, described image dispensing device possesses：Image obtains Take portion, obtain first resolution image, described first resolution image is to be clapped based on obtained from the shooting of digit microscope Take the photograph the image of object；High-definition picture acquisition unit, obtains second resolution image, described second resolution image is resolution Higher than the described first resolution image, figure of described subject obtained from the shooting based on described digit microscope Picture；And sending part, send described first resolution image or described second resolution image to described image reception device, Described image reception device possesses：Amplify receiving unit, accept for the described first resolution image shown by display device Amplification；Display output section, obtains described first resolution image or described second resolution from described image dispensing device Rate image, makes described display device show based on described first after being amplified by the described amplification that described amplification receiving unit accepts Image in different resolution or described second resolution image；And detection unit, judge to amplify, based on by described, the institute that receiving unit accepts Whether the evaluation of estimate stating amplification is higher than predetermined value, and result of determination is notified to described image dispensing device, described sending part In the case of the described result of determination higher than described predetermined value for representing institute's evaluation values, described second resolution image is sent out Deliver to described image reception device, in the situation for representing institute's evaluation values described result of determination high unlike described predetermined value Under, described first resolution image is sent to described image reception device.Additionally, evaluation of estimate related information is to comprise by amplifying Number of times, the display time of image of subject or the quilt of display that amplification that receiving unit accepts, amplification are accepted The information of the area of reference object etc..

Thus, even if for example there is no Pathology Doctors ' in placement as the place of a corpse or other object for laboratory examination and chemical testing for subject, positioned at remotely Pathology Doctors ' also can obtain, using image received device, the corpse or other object for laboratory examination and chemical testing sending from the picture transmitter device being arranged at this place Image, to carry out the diagnosis of the corpse or other object for laboratory examination and chemical testing based on this image.Now it is not necessary to high-definition picture do not send out to image received device Send, therefore, it is possible to mitigate the burden of the process of high-definition picture.

In addition, described image dispensing device can also possess the second output section, institute's commentary is being judged to by described detection unit In the case of being worth unlike described predetermined value height, described second resolution image is exported and preserves to note by described second output section Recording medium.

Thus, even if in the high-definition picture because evaluation of estimate is low (second resolution image) not to pathology remotely In the case that doctor sends, this high-definition picture is also saved.Therefore, think that high-definition picture is necessary in this Pathology Doctors ' In the case of, promptly this high-definition picture can be read from recording medium and send to Pathology Doctors '.

In addition, with regard to described image output device, described first resolution image is the first first resolution image, described Order makes at least one computing device described：Obtain the second first resolution image, described second first resolution image is The image of described subject obtained from shooting based on described digit microscope, described second resolution image is based on institute State the first first resolution image and described second first resolution image and generate, described digit microscope sends and described quilt Reference object be in the 1st angle the 1st light and with described subject be in the 2nd angle the 2nd light, send described 1st light it After send described 2nd light, described digit microscope is based on the 1st many pixel values and generates described first first resolution images, base Generate described second first resolution image, the quantity ratio of the pixel value of described second resolution image in the 2nd many pixel values The quantity of described 1st many pixel values is many, and, the quantity of the pixel value of described second resolution image is individual more than the described 2nd The quantity of pixel value is many, and described subject comprises part 1 and the part 2 adjacent with described part 1, Duo Geguang Electric converter section is based on described 1st light by the 1st conversion light obtained from described subject, and output comprises the 1st pixel value Described 1st many pixel values, based on described 2nd light by the 2nd conversion light obtained from described subject, output comprises the The described 2nd many pixel values of 2 pixel values, the plurality of photoelectric conversion part comprise the 1st photoelectric conversion part and with described 1st photoelectricity The 2nd adjacent photoelectric conversion part of converter section, described 1st photoelectric conversion part passes through the described 1st based on the part in described 1st light Obtained from part, a part for described 1st conversion light, export described 1st pixel value, described 2nd photoelectric conversion part be based on institute State a part in the 2nd light by obtained from described part 2, the part of described 2nd conversion light, export described 2nd picture Element value.

Additionally, the image output device of the present invention mode, picture transmitter device and image received device is each The individual non-transitory recording medium that can also be configured to possess at least one processor and keep order.In the case of being somebody's turn to do, above-mentioned is each Each element that device possesses is come real by using the order that this this recording medium of at least one computing device is kept Existing.

Hereinafter, referring to the drawings embodiment is specifically illustrated.

Additionally, the embodiment being described below is all embodiment that is master or representing specific example.With Under embodiment shown in numerical value, shape, material, element, the allocation position of element and connected mode, step Suddenly, order of step etc. simply one, is not intended to limit the present invention.In addition, in element in following embodiment , be not recorded in represent upper concept independent claims element, illustrated as arbitrary element.

(embodiment 1)

Fig. 1 is the pie graph of that illustrates to comprise the image processing system of the image output device of embodiment 1.

Image processing system 100S includes：Digit microscope 1500, image output device 1001 and display device 1501.

Digit microscope 1500 is following image acquiring devices, and a pathology corpse or other object for laboratory examination and chemical testing is clapped as subject Take the photograph.Here, in this manual, " digit microscope " is for examining at least a portion digital picture of slide glass specimen by pathological tissue The device changed.For example, digit microscope is to sense (CIS with contact type image：Contact Image Sensing) mode shoots Following image acquiring device of described specimen or virtual slide scanner (virtual slide scanner) etc..? This, be following device with the image acquiring device that CIS mode is shot：Directly configure subject on the image sensor To be shot, thus to be obtained the first resolution image of image and the second resolution image as subject.Tool For body, described image acquisition device from multiple different direction of illuminations to subject irradiation light to this subject Shot, thus generated multiple first resolution images.In addition, described image acquisition device is by these multiple first resolutions Each pixel of image is reconfigured at, and thus generates the high second resolution image of resolution ratio each first resolution image.Separately Outward, with regard to digit microscope 1500, following image acquiring devices can be replaced, and the enlarged drawing using the multiple resolution of generation The digit microscopes such as the virtual slide scanner of picture.Virtual slide scanner is the device to shoot a corpse or other object for laboratory examination and chemical testing through microscope.Weight Multiple carry out moving slide glass with respect to the operation of microscopical relative position with the operation that shot, the multiple images obtaining are spelled Close and generate the image of a large-scale corpse or other object for laboratory examination and chemical testing.In virtual slide scanner, microscopical object lens are installed on by conversion, to select Select the resolution of image to be obtained.When the object lens using low range, resolution step-down, but shoot the inspection in 1 image The scope of body becomes big, and therefore, shooting position is few, and shooting time shortens.With regard to image acquiring device, in embodiment 4 in detail Illustrate.

Display device 1501 is to show based on obtained from the shooting of digit microscope to operator's (such as Pathology Doctors ') The device of image, for example, is liquid crystal display or scialyscope etc..

Image output device 1001 obtains the image obtained from shooting by digit microscope 1500, and makes display device 1501 this image of display.In addition, image output device 1001 is via communication line, to for example operated by long-range Pathology Doctors ' Device sends this image.

This image output device 1001 possesses：Image acquiring unit 1101, high-definition picture acquisition unit 1102, amplification accept Portion 1201, detection unit 1202, display output section 1203, sending part 1204.

Image acquiring unit 1101 obtains first resolution image, and first resolution image is based on digit microscope 1500 The image of subject obtained from shooting.Additionally, the subject obtained from shooting based on digit microscope 1500 Image can be the image directly being obtained by this shooting or by processing to the image directly obtaining Obtained from image.Here, image acquiring unit 1101 is by by the such as contact image sensor in digit microscope 1500 Subimage obtained from shooting to obtain as first resolution image.Additionally, the resolution of first resolution image is referred to as First resolution.

High-definition picture acquisition unit 1102 obtains second resolution image, and second resolution image is and first resolution Image compares the image (high-definition picture) of high resolution, is to be taken obtained from the shooting based on digit microscope 1500 The image of object.High-definition picture acquisition unit 1102 can be obtained by generating second resolution image from multiple subimages This second resolution image is it is also possible to obtain second resolution image from digit microscope 1500.Additionally, by second resolution figure The resolution of picture is referred to as second resolution.Here, the pel spacing of first resolution is 0.9 μm, between the pixel of second resolution Away from for 0.3 μm.In addition, when by the pel spacing of first resolution with respect to the pel spacing of second resolution be used for differentiate During rate ratio, resolution ratio is 3.

Amplify receiving unit 1201 and accept the amplification for the first resolution image shown by display device 1501.Specifically For, amplify receiving unit 1201 to obtain amplification K as numerical value via the operation of such as keyboard.In addition, amplify accepting The rotation number of the mouse with roller for example can also be used by portion 1201 as the changing value of amplification, comes to amplification K It is updated.

Display output section 1203 exports to display device 1501 and puts based on by the amplification that amplification receiving unit 1201 accepts First resolution image after big or second resolution image.Thus, the first resolution image after amplification or second point Resolution image is shown in display device 1501.Additionally, the image output device 1001 in present embodiment possesses display with defeated Go out portion 1203 but it is also possible to not possess this display output section 1203.

Whether detection unit 1202 judges based on higher than predetermined value by the evaluation of estimate amplifying the amplification that receiving unit 1201 accepts. Here, predetermined value can be the value or predetermined value arbitrarily being set by such as Pathology Doctors ' or operator. Specifically, in evaluation of estimate as in 1 being accepted by amplification receiving unit 1201 or multiple amplification, maximum amplification And in the case of being exported, predetermined value can also be for example and resolution ratio (that is to say, be 3 in the case of above-mentioned example) phase Deng value.

Additionally, predetermined value is the value bigger than 1.But, if making predetermined value be low value, following output can continually be entered OK.In order to avoid such situation, predetermined value can also be to try to high value.Following output is executed by sending part 1204 The output sending or being executed by the first output section 1205.Then it is also possible to be configured to thickness according to communication line and/or The crowded state of circuit is switching predetermined value.For example, in the case of the circuit of the mobile phone thin using circuit, predetermined value is made to be high Value 10, in the case of the optical link thick using circuit, make predetermined value be low value 3.In addition, in the crowded situation of circuit Under, make predetermined value be high value 10, in the case of line idle, make predetermined value be low value 3.Alternatively, it is also possible to be configured to According to the used memorizer (for example, any one recording medium 1502 in following Fig. 8 and Figure 12～Figure 14) of preservation Size, to switch predetermined value.For example, it is possible to be high-capacity H DD (Hard Disk Drive in this memorizer：Hard drive Device) in the case of, make predetermined value be 3, be SSD (the Solid State Drive of low capacity in this memorizer：Solid state hard disc) In the case of, make predetermined value be 10.

Sending part 1204 be judged to by detection unit 1202 evaluation of estimate than predetermined value high in the case of, send second resolution Image.On the other hand, sending part 1204, in the case of be judged to evaluation of estimate unlike predetermined value height by detection unit 1202, does not send Second resolution image.Now, that is to say, in the case of being judged to that evaluation of estimate is not high by detection unit 1202, sending part 1204 Send first resolution image.First resolution image or second resolution image, via communication line, are sent to for example Device by long-range Pathology Doctors ' operation.

Fig. 2 is the figure of of the display picture illustrating to be shown by display device 1501.

Display device 1501 display comprises end key 602, eye view image display part 603, observed result input field 604, reads Take the display picture 601 of key 605 and enlarged drawing display part 606.

When selecting end key 602, display device 1501 sends to image output device 1001 and notifies to terminate image The signal of display.Show the entirety of first resolution image or second resolution image in eye view image display part 603.Seeing Examine the observed result that result input field 604 writes such as Pathology Doctors '.When selecting to read key 605, display device 1501 is to figure As output device 1001 send for example terminate first resolution image display, instruction second resolution image reading letter Number.In enlarged drawing display part 606, first resolution image or second resolution image show exaggeratedly.

Fig. 3 is the flow chart of of the process work illustrating image output device 1001.

First, the image acquiring unit 1101 of image output device 1001 obtains first resolution figure from digit microscope 1500 As (step S11).Then, amplify receiving unit 1201 and the amplification of image is accepted to the operation of such as keyboard etc. according to operator (step S12).Then, display output section 1203 so that the amplification being accepted is amplified to first resolution image to aobvious Showing device 1501 exports.By this output, display output section 1203 makes to be enlarged into the first resolution of accepted amplification Rate image is shown in (step S13) in display device 1501.

Then, display with output section 1203 be based on by end key 602 or read key 605 be chosen and from display device The signal of 1501 outputs, determines whether to terminate the display (step S14) of first resolution image.Here, work as to be judged to should Terminate (step S14 during display：No), amplify receiving unit 1201 and accept new amplification further.That is to say, observe display device The operator of the image shown by 1501 changes amplification according to a corpse or other object for laboratory examination and chemical testing and is observed.

On the other hand, (step S14 when being judged to terminate display：It is), detection unit 1202 is derived to be based on and is subject to by amplification The evaluation of estimate of the amplification that reason portion 1201 accepts, judges whether this evaluation of estimate is higher than predetermined value (step S15).

Amplification in e.g. accept in step s 12 1 of evaluation of estimate or multiple amplification, finally accepting The amplification (maximum amplification) of (last amplification) or maximum.That is to say, detection unit 1202 is by last amplification or Big amplification is derived as evaluation of estimate.Or, detection unit 1202 can also derive evaluation of estimate based on other important documents.For example, Other important documents be by step S12 accept the number of times (accepting number of times) of amplification, display device 1501 display image time (aobvious Show the time) and display device 1501 shown by the area (display area) of image at least one party.

In addition, detection unit 1202 can also to maximum amplification, accept number of times, the display time and display area each It is multiplied by coefficient, and they are added up, be derived there evaluation of estimate.

Here, when being judged to that evaluation of estimate is high unlike predetermined value (step S15：No), sending part 1204 is via communication line Send first resolution image, and do not send second resolution image (step S16).On the other hand, when being judged to evaluation of estimate ratio (step S15 when predetermined value is high：It is), high-definition picture acquisition unit 1102 obtains second resolution image (step S17).Enter And, sending part 1204 will be carried out via communication line by the second resolution image that this high-definition picture acquisition unit 1102 obtains Send (step S18).

In the flowchart of fig. 3, so that the amplification being accepted amplifies, shown image is only first resolution image, But as illustrated in the flow diagram of fig. 4, second resolution image can also be shown so that this amplification amplifies.

Fig. 4 is the flow chart of the other examples of process work illustrating image output device 1001.

First, the image acquiring unit 1101 of image output device 1001 obtains first resolution figure from digit microscope 1500 As (step S21).And, this first resolution image is exported by display output section 1203 to display device 1501, thus, makes Display device 1501 shows this first resolution image (step S22).

Then, amplify the amplification (step that receiving unit 1201 accepts image according to operator to the operation of such as keyboard etc. Rapid S23).Detection unit 1202 is derived based on by the evaluation of estimate amplifying the amplification that receiving unit 1201 accepts, and judges that this evaluation of estimate is No higher than predetermined value (step S24).

Here, when being judged to that evaluation of estimate is high unlike predetermined value (step S24：No), display is with output section 1203 by first Image in different resolution is enlarged into the amplification accepting in step S23 and exports to display device 1501.According to this output, display is used Output section 1203 makes display device 1501 show the first resolution image (step S25) after being exaggerated.Now, do not send second Image in different resolution.In addition, display with output section 1203 be based on by end key 602 or read key 605 be chosen and from display The signal of device 1501 output, determines whether to terminate the display (step S26) of first resolution image.Here, work as being judged to (step S26 during display should be terminated：It is), image output device 1001 end is processed.On the other hand, it is being judged to should not terminate to show (step S26 when showing：No), image output device 1001 executes the process starting from step S23 repeatedly.

In addition, in step s 24, (step S24 when being judged to that evaluation of estimate is higher than predetermined value：It is), detection unit 1202 is sentenced This does not determine whether the judgement first (step S27) to a corpse or other object for laboratory examination and chemical testing.Here, when be determined as be first when (step S27：It is), high Image in different resolution acquisition unit 1102 obtains second resolution image (step S28).And then, sending part 1204 is sent out via communication line Send this second resolution image (step S29) being obtained by high-definition picture acquisition unit 1102.

Or being determined as in step s 27 after sending second resolution image in step S29 is not (step when first S27：No), second resolution image is enlarged into the amplification accepting in step S23 and to display by display output section 1203 Device 1501 is exported.By this output, display device 1501 makes display device 1501 show the second resolution after being exaggerated Rate image (step S30).At this time it is also possible to be not amplified to second resolution image with the amplification accepting in step S23, And be amplified with removing value obtained from this amplification with resolution ratio.For example, the amplification being accepted be 3, resolution Than in the case of 3, second resolution image is enlarged into 1 times.

Then, display is chosen and the letter from display device 1501 output based on by end key 602 with output section 1203 Number, determine whether to terminate the display (step S31) of second resolution image.Here, when being judged to terminate display (step S31：It is), image output device 1001 end is processed.On the other hand, (step S31 when being judged to should not terminate display：No), Image output device 1001 executes the process starting from step S23 repeatedly.

(effect)

So, in the present embodiment, only in the case of evaluation of estimate height, send second resolution image.That is to say, energy Enough only to there being the necessary corpse or other object for laboratory examination and chemical testing of sufficient diagnosis (subject), with high-resolution by the image of this corpse or other object for laboratory examination and chemical testing for example to remotely It is transmitted.Thus it is for example possible to suppression just can carry out diagnosing the low corpse or other object for laboratory examination and chemical testing of such importance degree with the short time to send High-definition picture, and the transmission with the sufficient high-definition picture diagnosing a necessary corpse or other object for laboratory examination and chemical testing is postponed.In addition, by In the transmission of the high-definition picture not carrying out the low corpse or other object for laboratory examination and chemical testing of evaluation of estimate, therefore, it is possible to mitigate the process of high-definition picture Burden.

Specifically it is considered to image output device 1001 in present embodiment only lack of experience Pathology Doctors ' or Used in person's only civilian hospital of surgery.In this case, the inspection that will can be difficult to diagnose using sending part 1204 The second resolution image of body is remotely transmitted to the Pathology Doctors ' having experience to enrich.First, the first of low resolution Image in different resolution is sent to Pathology Doctors '.Then, can work as when having obtained high evaluation value, that is to say, only needing to a corpse or other object for laboratory examination and chemical testing When being diagnosed in more detail, send high-resolution second resolution image.Setting first resolution image as 100M byte (=800M bit), second resolution image be 1.6G byte, communication speed be 50Mbps in the case of, first resolution image Can be transmitted with 16 seconds, but the transmission of high-definition picture needs to expend 256 seconds.If sent all of with high-resolution Image, then quite expend the time.But, in the organism carrying out because of Gernral Check-up etc. checks, mostly with the figure of low resolution Without exception as just can determine that, therefore, by sending high-definition picture only for the corpse or other object for laboratory examination and chemical testing being necessary, diagnosis can be made efficient Change.In addition, image output device 1001 can be used in following situation：Only has the infirmary of a people in Pathology Doctors ', selecting will Important image sends transmission image when being checked to the Pathology Doctors ' being located at remotely.

(detailed content of evaluation of estimate)

Here, being described in detail to above-mentioned evaluation of estimate.

As described above, detection unit 1202 can be based at least one party accepting in number of times, display time and display area To derive evaluation of estimate.

Determining whether it is not must in diagnosis based on the evaluation of estimate that these accept number of times, display time or display area Must but to be to have so that whether high magnification carries out corpse or other object for laboratory examination and chemical testing observation, is necessary in diagnosis when will carry out that a corpse or other object for laboratory examination and chemical testing is observed with high magnification Effect.That is to say, common using microscopical diagnosis in, due to change lens waste time and energy, therefore, if carry out low Can learn in the stage of the observation of multiplying power that a corpse or other object for laboratory examination and chemical testing is normal, then not carry out powerful observation.Additionally, in a corpse or other object for laboratory examination and chemical testing whether just In normal judgement, no tumor or in the case of not remaining in diagnosis and being necessary inspection project in a corpse or other object for laboratory examination and chemical testing, it is judged as examining Body is normal.On the other hand, got using the such ultramicroscope of digit microscope 1500 of such as present embodiment The powerful amplification of image can only be carried out by the shirtsleeve operation of mouse or keyboard.Therefore, in digit microscope In 1500, for a corpse or other object for laboratory examination and chemical testing for the observation only having carried out based on common microscopical low range, carry out observation under high magnification Situation is extremely many.

This is to think, the diagnosis person such as Pathology Doctors ', doctor or laboratory technician observes the image after amplifying with high magnification, by Whether this is rightly carried out in order to the shooting confirming a corpse or other object for laboratory examination and chemical testing.Additionally, it is believed that being the following requirement due to diagnosis person：For normal A corpse or other object for laboratory examination and chemical testing also want to the picture as after amplify using the little region comprising in this corpse or other object for laboratory examination and chemical testing with high magnification to observe.

Accept number of times, display time or display surface with what the high magnification unnecessary for such diagnosis was observed The parameter such as long-pending is different according to hobby or the experience of diagnosis person.But, the numerical value of these parameters with high necessary to diagnosing The parameter of the observation under multiplying power is compared minimum.Therefore, in the present embodiment, by using based on accepting number of times, display time Or the evaluation of estimate of display area, can determine that seeing whether necessary to diagnosis under high magnification.In order to effectively flexible Apply limited communication bandwidth, it is also possible to not send high score when unnecessary high magnification is observed in such diagnosis Resolution image.

In addition, work as based at least one party's derivation evaluation of estimate accepting in number of times, display time and display area sending During high-definition picture, sending part 1204 can also be to this high-definition picture additional marking.That is to say, sending part 1204 is to height The additional parameter representing that this evaluation of estimate is used of image in different resolution (accepts in number of times, display time and display area at least One side) species and this evaluation of estimate labelling, and send the markd high-definition picture of this band.Thus, receive this high-resolution The image received device of rate image can extract and addition of the species being denoted as parameter and make from multiple high-definition pictures With for example accepting the high-definition picture of the labelling of number of times.In addition, if the high-definition picture being extracted is multiple, then scheme As reception device can based on the evaluation of estimate represented by these labellings, by these high-definition pictures press evaluation of estimate ascending order or Descending is arranged.Thus, diagnosis person can be readily selected the high-definition picture that should be observed.

(the detailed content of evaluation of estimate：Accept number of times)

Specifically, accept number of times be by amplify receiving unit 1201 accept the amplification higher than threshold value be high amplification time Number.This threshold value is, for example, above-mentioned resolution ratio (specifically 3).This accepts, and number of times is more, then detection unit 1202 is derived and got over High evaluation of estimate.For example, evaluation of estimate can also be to accept number of times itself.In this case, detection unit 1202 judges to comment as this Be worth whether accept number of times more than 1 time (predetermined value=1).That is to say, if accepting number of times is 1 time, is enlarged into height and puts The display of the first resolution image of big rate is not that the probability of the necessary display of diagnosis is high.In other words, by than high amplification The first resolution image of the low amplification of rate is judged as that a corpse or other object for laboratory examination and chemical testing is that normal probability is high.If on the contrary, accepting number of times is 2 More than secondary, then it is enlarged into the probability height being shown as diagnosing necessary display of the first resolution image of high amplification. That is to say, whether a corpse or other object for laboratory examination and chemical testing normally judges that suspectable probability is high.Therefore, so, judge to accept number of times whether ratio 1 time Many, when being judged to many, carry out the transmission of high-definition picture, thereby, it is possible to effectively flexibly use limited communication bandwidth.

Or, detection unit 1202 can also judge whether to accept number of times than 2 times (predetermined value=2) as this evaluation of estimate Many.Specifically, in the case of diagnosing malignant tumor, in order to confirm the pattern of tumor and size and mostly carry out 3 times with On diagnosis.For example, mostly carry out the respective diagnosis of center, left end and the right-hand member of tumor.Therefore, by as above-mentioned that Predetermined value is set to " 2 " by sample, can only send the high-definition picture suspecting the high corpse or other object for laboratory examination and chemical testing of probability being malignant tumor.

So, evaluation of estimate be based on accept number of times to derive in the case of, no matter the corpse or other object for laboratory examination and chemical testing under high magnification is observed is only to enter Row 1 time or only carry out less than 2 times, can suppress high-definition picture to be sent.That is, can suppress：Because carried out for The corpse or other object for laboratory examination and chemical testing diagnosing under unnecessary high magnification is observed, and have sent high-definition picture.

(the detailed content of evaluation of estimate：The display time)

Specifically, the display time be subject image with high amplification be shown device 1501 shown by when Between.This display time is more long then, and detection unit 1202 derives higher evaluation of estimate.For example, evaluation of estimate can also be subject Image with high amplification more than above-mentioned resolution ratio (specifically 3) be shown device 1501 display display when Between.Should in the case of, detection unit 1202 judges the display time whether ratio such as 10 seconds (predetermined value=10 second) as this evaluation of estimate Long.That is to say, if this display time is less than 10 seconds, the display being enlarged into the image of high amplification is that diagnosis is needed not The probability of the display wanted is high.Thereby, it is possible to suppress：Observed because diagnosing the corpse or other object for laboratory examination and chemical testing under unnecessary high magnification, and Have sent high-definition picture.

In addition, the time spending required for the diagnosis of malignant tumor exists according to the position difference of diagnosis person or observation Difference.Therefore, it can according to diagnosis person, observe position or a corpse or other object for laboratory examination and chemical testing acquisition creating method, to change this predetermined value ( It is 10 seconds in above-mentioned example).For example, for the corpse or other object for laboratory examination and chemical testing being made with usual way, this predetermined value is set to 10 seconds, for handss In art, this predetermined value can be set to 30 seconds by the corpse or other object for laboratory examination and chemical testing being made with the short time of rapid diagnosis.

In addition, in above-mentioned example, predetermined value is made to be 10 seconds or 30 seconds but it is also possible to observation by a normal corpse or other object for laboratory examination and chemical testing Average time of m times (m is the real number bigger than 1) of display time of required cost etc. is as predetermined value.

In addition, detection unit 1202 can also be directed to each amplification (that is to say, more than 3 high amplification) being accepted, It is multiplied by weight on the display time under this amplification, the summation of the display time of each Weight to be led as evaluation of estimate Go out.Amplification is higher, then its weight is bigger value.Specifically, amplification itself to be located by detection unit 1202 as weight Reason, Utilization assessment value=Σ [amplification (k) × display time (k)], derives evaluation of estimate.Additionally, amplification (k) is to be subject to for k-th The amplification of more than the 3 of reason, display time (k) is aobvious shown by the first resolution image after being amplified with k-th amplification Show the time.That is to say, in the case that the amplification more than resolution ratio has accepted n time, the amplification that evaluation of estimate is 1～n as k The summation of rate (k) × display time (k) and be exported.For example, the amplification Q being accepted and display time T (second) now is (Q, T)=(3,7), (4,6), (5,5) and (6,4).In this case, detection unit 1202 pass through evaluation of estimate=(3 × 7)+(4 × 6)+(5 × 5)+(6 × 4), and derive evaluation of estimate.Additionally, it is also possible to replace amplification in the calculating of evaluation of estimate (k), and use " amplification (k)-resolution ratio (specifically 3)+1 ".In this case, detection unit 1202 passes through evaluation of estimate =(1 × 7)+(2 × 6)+(3 × 5)+(4 × 4), and derive evaluation of estimate.If utilizing this evaluation of estimate, observing time is longer Or the amplification (multiplying power) when observing is higher, then derive higher evaluation of estimate.In addition, in this case, detection unit 1202 Can be determined that whether evaluation of estimate exceedes such as 30 (predetermined value=30).

Additionally, after detection unit 1202 calculates the display time under each amplification, derive evaluation of estimate but it is also possible at any time more Evaluation of estimate during New Observer.That is to say, detection unit 1202 can just obtain amplification when observing often through certain time, will In the evaluation of estimate that the result of product of this amplification getting and certain time derives before being added in just, thus to this evaluation of estimate It is updated.Thus, often through certain time, just derive new evaluation of estimate.

In addition, detection unit 1202 replacement is multiplied by amplification to the display time it is also possible to be multiplied by with respect to putting to the display time The value of big rate monotone increasing.It is the value being obtained by function with respect to the value of amplification monotone increasing, for example, be the right of amplification Number.That is to say, detection unit 1202 passes through evaluation of estimate=Σ [log amplification (k) × display time (k)], derive evaluation of estimate.

In addition, detection unit 1202 replacement derives evaluation of estimate by summation as described above it is also possible to will be with the display time It is worth to derive as evaluation of estimate obtained by the logarithm of amplification or amplification is integrated.

(the detailed content of evaluation of estimate：Display area)

Specifically, display area is the area of the subject being shown in display device 1501 with this high amplification. For example, detection unit 1202 determines the region of subject of appearing before one's eyes out in a frame using rim detection, calculates this and determines Region area be used as subject image area.In addition, being detected in a frame using rim detection In the case of multiple regions, detection unit 1202 can also by the plurality of region, for example comprise user mouse instruction The area in the region of position (coordinate) is as the area of the image of subject.If here, the image of this display is removed, The area of the image of the new display of display area exhibitions width.That is to say, in the position (that is, coordinate) comprising the instruction of user mouse Region continuous in the case of (that is, in the case of unskirted), when user removes image, the continuously new area with this region Domain occurs.Then, detection unit 1202 by this emerging region and can be and the position comprising the instruction of user mouse The continuous region in region area be added in subject the area of image on.Additionally, being taken as display area The area of object is to be obtained by the area of the image with the actual amplification above-mentioned subject calculating of removal Value (business).This display area is bigger, then detection unit 1202 derives higher evaluation of estimate.

For example, evaluation of estimate be with resolution ratio (specifically 3) more than the subject that shows of high amplification Display area.In this case, detection unit 1202 judges the display area whether ratio 10 as this evaluation of estimate, 000 μm²Greatly.When Resolution ratio be 3 when, if set with the position of adjacent 2 corresponding corpse or other object for laboratory examination and chemical testing of pixel be spaced apart 1/3 μm (=0.333 μm), The area of the corpse or other object for laboratory examination and chemical testing then being photographed by 1 pixel becomes 1/9 μm², and 10,000 μm²The size of a corresponding corpse or other object for laboratory examination and chemical testing becomes 10,000 μ m²/(1/9μm²)=9 × 10⁴Pixel.Namely it is decided that portion 1202 determines whether ratio 9 × 10⁴Pixel (predetermined value=9 × 10⁴Pixel) Greatly.That is to say, if this display area is 9 × 10⁴Below pixel, then it is enlarged into the first resolution image of high amplification Display is not that the probability of the display required for diagnosis is high.Thereby, it is possible to suppress because being carried out with diagnosing unnecessary high magnification A corpse or other object for laboratory examination and chemical testing is observed and can be sent high-definition picture.

In addition, in above-mentioned example, if predetermined value is 10,000 μm²(that is, 9 × 10⁴Pixel) but it is also possible to will be normal Area of m times (m is the real number bigger than 1) of average display area required for the observing an of corpse or other object for laboratory examination and chemical testing etc. as predetermined value.

In addition, detection unit 1202 can also by the amplification (that is to say, more than 3 high amplification) that each is accepted, Display area under this amplification superior with weight, the summation each being carried the display area of weight is led as evaluation of estimate Go out.Amplification is higher, and this weight is bigger value.Specifically, detection unit 1202 using amplification square as weight process, Detection unit 1202 derives evaluation of estimate by evaluation of estimate=Σ [amplification (k) ^2 × display area (k)].Additionally, amplification (k) As described above, be accept for k-th more than 3 amplification, display area (k) is being clapped after being amplified with k-th amplification Take the photograph the display area of object.Additionally, A^B represents the calculating of the B power of A.That is to say, the amplification more than resolution ratio accepts In the case of n time, the summation of amplification (k) ^2 × display area (k) that evaluation of estimate is 1～n as k derives.For example, if Amplification Q and display area S (1 × 10 now⁴Pixel) it is (Q, S)=(3,2), (4,0.5), (5,1.5), (6,1).At this In the case of sample, detection unit 1202 passes through evaluation of estimate=[(3^2) × 2 × 10⁴]+[(4^2)×0.5×10⁴]+[(5^2)×1.5 ×10⁴]+[(6^2)×1×10⁴], derive evaluation of estimate.Additionally, in the calculating of evaluation of estimate, replace amplification (k) square, Can be used " amplification (k)-resolution ratio (specifically 3)+1 " square as weight.In this case, detection unit 1202 By evaluation of estimate=[(1^2) × 2 × 10⁴]+[(2^2)×0.5×10⁴]+[(3^2)×1.5×10⁴]+[(4^2)×1× 10⁴] and derive evaluation of estimate.If using such evaluation of estimate, when the area of the subject observed is bigger or observes Amplification (multiplying power) is higher, then derive higher evaluation of estimate.In addition, in this case, detection unit 1202 can also judge to evaluate Whether value exceedes such as 8.1 × 10⁵(predetermined value=8.1 × 10⁵).

Additionally, weight to be amplification more high is then bigger value, as long as the function of value as can calculating, just not Be limited to amplification square, it is possible to use arbitrary function.For example, detection unit 1202 [can be amplified by evaluation of estimate=Σ Rate (k) ^3 × display area (k)] deriving evaluation of estimate.

In addition, detection unit 1202 can replace as described above evaluation of estimate is derived by summation, and will be to show area The power of amplification is taken advantage of and is worth to derive as evaluation of estimate obtained by being integrated.

(variation)

Here, illustrating to the variation of the image output device in embodiment 1.The image output dress of this variation Put in the case of evaluation of estimate height, send and preserve second resolution image.

Fig. 5 is the pie graph of of the image processing system of the image output device illustrating to comprise this variation.

The image processing system 100Sa of this variation includes：Digit microscope 1500, image output device 1001a, display Device 1501 and recording medium 1502.

Recording medium 1502 keeps the image from image output device 1001a output.This recording medium 1502 is by for example hard Disk, BD (Blu-ray (registered trade mark) Disc), DVD, SD card (registered trade mark), RAM (Random Access Memory：At random Access memorizer) or the storage device such as cache realizing.

Each structure that image output device 1001a possesses except the image output device 1001 possessing above-mentioned embodiment 1 Become outside key element, be also equipped with the first output section 1205.

First output section 1205 be judged to by detection unit 1202 evaluation of estimate than predetermined value high in the case of, by second differentiate Rate image exports and preserves to recording medium 1502.On the other hand, the first output section 1205 is being judged to comment by detection unit 1202 In the case of being worth unlike predetermined value height, do not export second resolution image to recording medium 1502.

In other words, the image sending from sending part 1204 is exported by the first output section 1205 to recording medium 1502, thus, This image is stored in recording medium 1502.That is to say, the first output section 1205 is by step S16, S18 of Fig. 3 or Fig. 4 In step S29, the first resolution image sending or second resolution image are stored in recording medium 1502.

(effect)

In the image output device 1001a of such variation, can be diagnosed with high-resolution for needs A corpse or other object for laboratory examination and chemical testing, automatically preserve high-definition picture (second resolution image).It is also contemplated that setting chooses whether to preserve high score The button of resolution image, but it is contemplated that Pathology Doctors ' carried out the diagnosis of more than 60 corpse or other object for laboratory examination and chemical testing sometimes in one hour, can forget Note button operation.But, if using the image output device 1001a of this variation, it is prevented from forgetting to operate, Neng Gouke Preserve important high-definition picture by ground.

In addition, if using the image output device 1001a of this variation, then can examine to high-definition picture A disconnected corpse or other object for laboratory examination and chemical testing preserves and sends this high-definition picture, can examine to low-resolution image (first resolution image) A disconnected corpse or other object for laboratory examination and chemical testing preserves and sends this low-resolution image.Thus, be saved by making and the size of image that sends be with The corresponding size of a corpse or other object for laboratory examination and chemical testing, the size that preserved image can be cut down, the size of image being sent (transfer) and transfer Time.

(embodiment 2)

Image output device in present embodiment is by the picture transmitter device mutually connecting via communication line and image Reception device is constituted.Additionally, in the device in present embodiment and its element and embodiment 1 identical dress Put and its element, mark and embodiment 1 identical label, and omit their detailed description.

Image processing system 200S includes：Digit microscope 1500, image output device 2001, display device 1501, note Recording medium 1502 and recording medium 1503.

Recording medium 1502 keeps the image of image received device 1200 output from image output device 2001.

Recording medium 1503 keeps the image of picture transmitter device 1100 output from image output device 2001.This record Medium 1503 is same with recording medium 1502, by such as hard disk, BD (Blu-ray (registered trade mark) Disc), DVD, SD card (registration Trade mark), the storage device such as RAM or cache realizes.

Image output device 2001 possesses and connects via the interconnective picture transmitter device of communication line 1100 and image Receiving apparatus 1200.Additionally, image output device 2001 is as entirety, have same with the image output device 1001 of embodiment 1 The function of sample.In addition, for example, comprise assembling of digit microscope 1500, picture transmitter device 1100 and recording medium 1503 It is placed in the no facility such as hospital of Pathology Doctors '.Comprise image received device 1200, display device 1501 and recording medium 1502 Group be for example configured at away from this hospital, the facility that has Pathology Doctors '.

Picture transmitter device 1100 possesses：Image acquiring unit 1101, high-definition picture acquisition unit 1102, sending part 1204 And second output section 1103.

Second output section 1103 exports the second resolution image being obtained by high-definition picture acquisition unit 1102 to note This second resolution image is thus stored in recording medium 1503 by recording medium 1503.That is to say, this second output section 1103 exists In the case of being judged to evaluation of estimate unlike predetermined value height by detection unit 1202, second resolution image is exported and preserves to record Medium 1503.

Image received device 1200 possesses：Amplify receiving unit 1201, detection unit 1202, display with output section 1203 and the One output section 1205.

Display with output section 1203 from picture transmitter device 1100 via communication line obtain first resolution image or Second resolution image.Then, in the same manner as embodiment 1, display output section 1203 is based on to display device 1501 output First resolution image after being amplified by the amplification that amplification receiving unit 1201 accepts or second resolution image.Thus, Display output section 1203 makes display device 1501 show first resolution image or second resolution image after being exaggerated.

Detection unit 1202, in the same manner as embodiment 1, judges whether evaluation of estimate is higher than predetermined value.And, detection unit 1202 Via communication line, this result of determination is notified picture transmitter device 1100.

The sending part 1204 of picture transmitter device 1100 in the case of for representing the high result of determination of evaluation of estimate, via logical Second resolution image is sent by letter circuit to image received device 1200.On the other hand, sending part 1204 is being evaluated for representing In the case of being worth not high result of determination, send first resolution image to replace sending second resolution figure via communication line Picture.

Fig. 7 is the flow chart of the process work illustrating picture transmitter device 1100 and image received device 1200.

The image acquiring unit 1101 of picture transmitter device 1100 obtains first resolution image (step from digit microscope 1500 Rapid S41).First resolution image is sent (step S42) to image received device 1200 via communication line by sending part 1204.

The display output section 1203 of image received device 1200 receives via communication line from picture transmitter device 1100 The first resolution image (step S51) sending.Then, the amplification receiving unit 1201 of image received device 1200 is according to operation Person to accept the amplification of image (step S52) to the operation of such as keyboard etc..Then, display output section 1203 is to be accepted Amplification by first resolution image amplify and export to display device 1501.Display passes through this output with output section 1203, Display device 1501 is made to show the first resolution image (step S53) being enlarged into accepted amplification.

Then, the display of image received device 1200 is based on by end key 602 with output section 1203 or reads key 605 It is chosen and the signal from display device 1501 output, determine whether to terminate the display (step S54) of first resolution image. Here, when being judged to should not to terminate display (step S54：No), amplify receiving unit 1201 and accept new amplification further.? It is that the operator's (Pathology Doctors ') observing the image shown by display device 1501 changes amplification according to a corpse or other object for laboratory examination and chemical testing and carries out Observe.

On the other hand, (step S54 when being judged to terminate display：It is), detection unit 1202 is derived to be based on and is subject to by amplification The evaluation of estimate of the amplification that reason portion 1201 accepts, judges whether this evaluation of estimate is higher than predetermined value (step S55).

Here, when being judged to that evaluation of estimate is high unlike predetermined value (step S55：No), the first of image received device 1200 First resolution image is exported and preserves to recording medium 1502 (step S59) by output section 1205.On the other hand, when being judged to (step S55 when evaluation of estimate is higher than predetermined value：It is), the first output section 1205 please to picture transmitter device 1100 via communication line Seek second resolution image (step S56).

The sending part 1204 of picture transmitter device 1100 determines whether to request the second resolution by image received device 1200 Rate image (step S43).Here, when being judged to not ask (step S43：No), high-definition picture acquisition unit 1102 obtains Second resolution image (step S44).In addition, the second output section 1103 should by obtained by high-definition picture acquisition unit 1102 Second resolution image exports and preserves to recording medium 1503 (step S45).Therefore, this second output section 1103 is by judging In the case that portion 1202 is judged to that evaluation of estimate is not high, second resolution image is exported and preserves to recording medium 1503.

On the other hand, (step S43 when being judged to request second resolution image：It is), high-definition picture obtains Portion 1102 obtains second resolution image (step S46).In addition, sending part 1204 will be obtained by high-definition picture acquisition unit 1102 This second resolution image taking sends to image received device 1200 (step S47) via communication line.Therefore, sending part 1204 is same with embodiment 1, in the case of be judged to evaluation of estimate height by detection unit 1202, sends second resolution image, In the case of being judged to that evaluation of estimate is not high by detection unit 1202, do not send second resolution image.

Additionally, in above-mentioned example, after the judgement of step S43, the process of execution step S44 and step S46, But can also execute before the judgement of step S43.

When sending second resolution image in step S47, the first output section 1205 of image received device 1200 connects Receive this second resolution image (step S57).Then, the first output section 1205 this second resolution image is exported and preserve to Recording medium 1502 (step S58).

(effect)

In the image output device 2001 of such present embodiment, even if obtaining the facility of the image of subject Separate it is also possible to realize the effect same with embodiment 1 with the facility observing this image.

(variation 1)

Here, illustrating to the 1st variation of the image output device in embodiment 2.In this variation, in pin In the case that multiple corpse or other object for laboratory examination and chemical testing are judged to evaluation of estimate height, send out successively from second resolution image corresponding with a corpse or other object for laboratory examination and chemical testing for high evaluation value Send multiple second resolution images.

Fig. 8 is the pie graph of of the image processing system of the image output device illustrating to comprise this variation.

The image processing system 200Sa of this variation includes：Digit microscope 1500, image output device 2001a, display Device 1501, recording medium 1502 and recording medium 1503.

Image output device 2001a possesses via communication line interconnective picture transmitter device 1100a and image Reception device 1200a.

Image received device 1200a will except each composition that the image received device 1200 possessing embodiment 2 possesses Outside element, it is also equipped with evaluation of estimate storage part 1206.Being stored with this evaluation of estimate storage part 1206, (it is right to be taken for each corpse or other object for laboratory examination and chemical testing As) evaluation of estimate that derives.In addition, the first output section 1205 is to picture transmitter device 1100a request and evaluation of estimate storage part 1206 The each evaluation of estimate corresponding second resolution image being stored.

Picture transmitter device 1100a replaces the sending part 1204 in embodiment 2, and possesses sending part 1204a.This transmission Portion 1204a not only has the function same with the sending part 1204 in embodiment 2, is also receiving from the first output section In the case of 1205 request, send multiple second points from second resolution image corresponding with a corpse or other object for laboratory examination and chemical testing for high evaluation value successively Resolution image.

Fig. 9 is the flow chart of the process work illustrating picture transmitter device 1100a and image received device 1200a.

The image acquiring unit 1101 of picture transmitter device 1100a and high-definition picture acquisition unit 1102 obtain and are taken The first resolution image of object and second resolution image (step S71).Sending part 1204a is via communication line by first Image in different resolution sends (step S72) to image received device 1200a.And, image acquiring unit 1101 and high resolution graphics As acquisition unit 1102 determines whether there is next subject (step S73).Right when being determined that the next one is taken As when (step S73：It is), picture transmitter device 1100a executes the process starting from step S71 repeatedly.

The display output section 1203 of image received device 1200a receives via communication line from picture transmitter device The first resolution image (step S81) that 1100a sends.Then, the amplification receiving unit of image received device 1200a 1201 According to operator, the operation of such as keyboard etc. is accepted with the amplification (step S82) of image.Then, display with output section 1203 with institute First resolution image is amplified and exports to display device 1501 by the amplification accepting.It is defeated that display passes through this with output section 1203 Go out, make display device 1501 show the first resolution image (step S83) being enlarged into accepted amplification.

Then, the display of image received device 1200a is based on by end key 602 with output section 1203 or reads key 605 are chosen and the signal from display device 1501 output, determine whether to terminate the display (step of first resolution image S84).Here, when being judged to should not to terminate display (step S84：No), amplify receiving unit 1201 and accept new amplification further Rate.That is to say, the operator's (Pathology Doctors ') observing the image shown by display device 1501 changes amplification according to a corpse or other object for laboratory examination and chemical testing And observed.

On the other hand, (step S84 when being judged to terminate display：It is), detection unit 1202 is derived to be based on and is subject to by amplification The evaluation of estimate of the amplification that reason portion 1201 accepts, judges whether this evaluation of estimate is higher than predetermined value (step S85).

Here, when being judged to that evaluation of estimate is high unlike predetermined value (step S85：No), the first of image received device 1200a First resolution image is exported and preserves to recording medium 1502 (step S87) by output section 1205.On the other hand, when being judged to (step S85 when evaluation of estimate is higher than predetermined value：It is), this evaluation of estimate higher than predetermined value is built by detection unit 1202 with subject Stand association and be stored in evaluation of estimate storage part 1206 (step S86).

Then, the display output section 1203 of image received device 1200a determines whether there is next subject (step S88).Here, when being determined that next subject (step S88：It is), image received device 1200a is anti- Execute the process starting from step S81 again.On the other hand, (step S88 during a subject in the absence of being judged to： No), the evaluation of estimate that first output section 1205 of image received device 1200a is preserved with reference to evaluation of estimate storage part 1206.In addition, First output section 1205 is sent in order from high evaluation of estimate via communication line request picture transmitter device 1100 and is commented with this It is worth the second resolution image (step S89) of the subject setting up association.

The sending part 1204a of picture transmitter device 1100a determines whether to request second point by image received device 1200a Resolution image (step S74).Here, when being judged to not ask (step S74：No), the second output section 1103 will be in step S71 The second resolution image of each subject of middle acquisition exports and preserves to recording medium 1503 (step S75).The opposing party Face, sending part 1204a (step S74 when being judged to request second resolution image：It is), by obtain in step S71 In the second resolution image of each subject, send with the evaluation of estimate corresponding second resolution image higher than predetermined value To image received device 1200a.Now, sending part 1204a from the second resolution image of high evaluation of estimate in order by this A little second resolution images send (step S76) via communication line to image received device 1200a.

First output section 1205 of image received device 1200a connects from the high second resolution image of evaluation of estimate in order Receive each second resolution image corresponding with the evaluation of estimate higher than predetermined value and export to recording medium 1502 (step S90).By This, than predetermined value, each second resolution image of high evaluation of estimate is stored in recording medium 1502.

(effect)

So, in this variation, when collecting the second resolution being judged as the high multiple subjects of evaluation of estimate When image is to be transmitted, it is transmitted successively from the high second resolution image of evaluation of estimate.Therefore, it is possible to promptly send weight Spend high second resolution image.As a result, Pathology Doctors ' can use from the high second resolution image of importance degree successively This second resolution image is carrying out the diagnosis of a corpse or other object for laboratory examination and chemical testing.

That is to say it is believed that the place of the Pathology Doctors ' in only lack of experience for the picture transmitter device 1100a or only surgery Hospital is used.In this case it is difficult to the second resolution image of a corpse or other object for laboratory examination and chemical testing for diagnosis has been sent to by sending part 1204a The large hospital of veteran Pathology Doctors '.Although communication line exists limiting, if using the image in this variation Output device 2001a, then preferentially can send out the second resolution image of the corpse or other object for laboratory examination and chemical testing being difficult to diagnose to large hospital from civilian hospital Send.In addition, picture transmitter device 1100a can select to send out important image in the Pathology Doctors ' only infirmary of a people Deliver to and be located at Pathology Doctors ' remotely and be utilized during transmission image when being checked.

Additionally, in pathologic finding, there is the situation from the multiple corpse or other object for laboratory examination and chemical testing of same patient.For example, in the inspection of cancer, Obtain a part for internal organs sometimes, observe the section in the different section of this part.That is, by shooting on above-below direction not With position (for the sake of convenient, referred to as different height) corpse or other object for laboratory examination and chemical testing section, obtain the images of multiple two dimensions, using these images, To confirm the scope of the cancer of three-dimensional.Here, suspect in the image arbitrarily highly gone up be cancer in the case of it is desirable to by this image And the other image highly gone up also is transmitted with high-resolution or keeps.

Then, high-definition picture acquisition unit 1102 can also be to multiple second obtaining from the same internal organs of same patient Image in different resolution adds same image set identifier.In this case, sending part 1204a when send second resolution image when, Also send setting up, with the image set identifier being attached to this second resolution image, the other second resolution images associating To image received device 1200a.Thus, the Pathology Doctors ' of operation image received device 1200a need not select for same respectively Multiple second resolution images that the same internal organs of patient obtain, and can unify to obtain, can in the way of three-dimensional simply Confirm scope of cancer etc..

(variation 2)

In above-mentioned embodiment 2 and its variation 1, detection unit 1202 located at image received device but it is also possible to located at Picture transmitter device.The picture transmitter device of the 2nd variation possesses detection unit 1202.

Figure 10 is the pie graph of of the image processing system of the image output device illustrating to comprise this variation.

The image processing system 200Sb of this variation possesses：Digit microscope 1500, image output device 2001b, display Device 1501, recording medium 1502 and recording medium 1503.

Image output device 2001b possesses via communication line interconnective picture transmitter device 1100b and image Reception device 1200b.

Picture transmitter device 1100b is had except the picture transmitter device 1100a possessing embodiment 2 and its variation 1 Outside standby each element, it is also equipped with detection unit 1202.

Image received device 1200b does not possess detection unit 1202, possesses amplification receiving unit 1201, display output section 1203 And first output section 1205.

Figure 11 is the flow chart of the process work illustrating picture transmitter device 1100b and image received device 1200b.

The image acquiring unit 1101 of picture transmitter device 1100b obtains first resolution image from digit microscope 1500 (step S101).Sending part 1204 sends first resolution image to image received device 1200 (step via communication line S102).

The display output section 1203 of image received device 1200b receives via communication line from picture transmitter device The first resolution image (step S121) that 1100b sends.Then, the amplification receiving unit 1201 of image received device 1200b The amplification (step S122) of image is accepted to the operation of such as keyboard etc. according to operator.Then, display output section 1203 export to display device 1501 so that first resolution image is amplified by the amplification being accepted.Output section 1203 is used in display By this output, display device 1501 is made to show the first resolution image (step being enlarged into accepted amplification S123).

Then, the display of image received device 1200b is based on by selecting end key 602 or reading with output section 1203 Key 605 and from display device 1501 output signal, determine whether to terminate the display (step S124) of first resolution image. Here, (step S124 at the end of ought being judged to make display：No), amplify receiving unit 1201 and accept new amplification further Rate.That is to say, observe display device 1501 shown by image operator's (Pathology Doctors ') according to a corpse or other object for laboratory examination and chemical testing change amplification Observed.On the other hand, (step S124 at the end of being judged to make display：It is), display output section 1203 will be evaluated The evaluation of estimate related information necessary to derivation of value sends (step S126) via communication line to picture transmitter device 1100b. This evaluation of estimate related information is, for example, above-mentioned last amplification, maximum amplification, display number of times, display time and display surface At least one party in long-pending.

The detection unit 1202 of picture transmitter device 1100b receives this evaluation of estimate related information (step S104).Then, it is determined that Portion 1202 is based on this evaluation of estimate related information and derives evaluation of estimate.And then, whether detection unit 1202 judges derived evaluation of estimate Higher than predetermined value, via communication line, its result of determination is notified image received device 1200b (step S105).

First output section 120 of image received device 1200b is worked as via communication line from picture transmitter device 1100b reception During notified result of determination (step S127), confirm that whether this result of determination is the (YES) (step S128) of affirmative.Here, working as Confirm that result of determination is negative, that is to say, (step S128 when evaluation of estimate is high unlike predetermined value：No), image received device First resolution image is exported and preserves to recording medium 1502 (step S132) by first output section 1205 of 1200b.Another Aspect, when confirming that result of determination is affirmative, that is to say, (step S128 when evaluation of estimate is higher than predetermined value：It is), image-receptive fills The first output section 1205 putting 1200b asks second resolution image (step via communication line to picture transmitter device 1100 S129).

The sending part 1204 of picture transmitter device 1100b determines whether to request second point by image received device 1200b Resolution image (step S106).Here, when being judged to not ask (step S106：No), high-definition picture acquisition unit 1102 Obtain second resolution image (step S107).And then, the second output section 1103 will be obtained by high-definition picture acquisition unit 1102 This second resolution image taking exports and preserves to recording medium 1503 (step S108).

On the other hand, (step S106 when being judged to request second resolution image：It is), high-definition picture obtains Portion 1102 obtains second resolution image (step S109).And, sending part 1204 will be by high-definition picture acquisition unit 1102 This second resolution image obtaining sends (step S110) via communication line to image received device 1200b.

Additionally, in above-mentioned example, after the judgement of step S106, carrying out the place of step S107 and step S109 Reason is it is also possible to carry out the process of step S107 and step S109 before the judgement of step S106.

When sending second resolution image in step s 110, first output section 1205 of image received device 1200b Receive this second resolution image (step S130).Then, this second resolution image is exported and protects by the first output section 1205 Deposit to recording medium 1502 (step S131).

(effect)

So, in this variation, even if detection unit 1202 located at picture transmitter device 1100b it is also possible to realize with upper State the same effect of embodiment 1 and 2.

In addition, in this variation, also with variation 1 it is also possible to associate setting up with the evaluation of estimate higher than predetermined value Each second resolution images of multiple subjects carry out in order from the high second resolution image of this evaluation of estimate Send and receive.

(embodiment 3)

It is in above-mentioned embodiment 1, embodiment 2 and their variation, whether high than predetermined value according to evaluation of estimate, To switch transmission second resolution image or not send second resolution image.In the present embodiment, do not carry out above-mentioned sending out Send the switching with non-sent, but whether high than predetermined value according to evaluation of estimate, switching preserves second resolution image or does not preserve Second resolution image.Additionally, in the device in present embodiment and its element with embodiment 1 or 2 phases Same device and its element, mark and embodiment 1 or 2 identical labels, and omit their detailed description.

Figure 12 is the pie graph of that illustrates to comprise the image processing system of the image output device of embodiment 3.

Image processing system 300S include digit microscope 1500, image output device 3001, display device 1501 and Recording medium 1502.

Image output device 3001 possesses：Image acquiring unit 1101, high-definition picture acquisition unit 1102, amplification receiving unit 1201st, output section 1203, the first output section 1205 are used in detection unit 1202, display.That is to say, the image output in present embodiment Sending part 1204 in each element that the image output device 1001 of device 3001 replacement embodiment 1 possesses and possess First output section 1205.Additionally, the image output device 3001 in present embodiment possesses display output section 1203, but with reality Apply mode 1 equally it is also possible to not possess this display output section 1203.

First output section 1205 is same with the variation of embodiment 1, is being judged to evaluation of estimate than pre- by detection unit 1202 In the case of definite value height, second resolution image is exported and preserves to recording medium 1502.On the other hand, the first output section 1205, in the case of be judged to evaluation of estimate unlike predetermined value height by detection unit 1202, second resolution image are not situated between to record Matter 1502 exports.

(effect)

Thus, in the present embodiment, same with the variation of embodiment 1, for the diagnosis needing under high-resolution A corpse or other object for laboratory examination and chemical testing, can automatically preserve high-definition picture (second resolution image).In addition, be directed to not needing under high-resolution A corpse or other object for laboratory examination and chemical testing for diagnosis, does not preserve high-definition picture, the idle capacity therefore, it is possible to suppress recording medium 1502 is restricted.

(variation 1)

Image output device 3001 in above-mentioned embodiment 3 constitutes but it is also possible to as embodiment as 1 device 2 like that, are made up of 2 devices.Image output device in this variation is sent by the image mutually connecting via communication line Device and image received device are constituted.

Figure 13 is the image procossing system representing the image output device involved by the 1st variation comprising in embodiment 3 The pie graph of of system.

Image processing system 300Sa be configured to including：Digit microscope 1500, image output device 3001a, display device 1501 and recording medium 1502.

Image output device 3001a possesses interconnective picture transmitter device 3100a and figure via communication line As reception device 3200a.Additionally, image output device 3001a is as the overall image output device having with embodiment 3 3001 same functions.In addition, for example, comprise digit microscope 1500 and the group of picture transmitter device 3100a is configured in The no facility such as hospital of Pathology Doctors '.Comprise the group of image received device 3200a, display device 1501 and recording medium 1502 For example it is configured at away from this hospital, the facility that has Pathology Doctors '.

Picture transmitter device 3100a possesses image acquiring unit 1101.Image acquiring unit 1101 obtains from digit microscope 1500 Take first resolution image, via communication line, this first resolution image is sent to image received device 3200a.

Image received device 3200a possesses：High-definition picture acquisition unit 1102, amplification receiving unit 1201, detection unit 1202nd, output section 1203 and the first output section 1205 are used in display.High-definition picture acquisition unit 1102 basis of this variation From the request of the first output section 1205, obtain multiple first resolution figures via communication line from picture transmitter device 3100a Picture.And, high-definition picture acquisition unit 1102 is based on these first resolution images and generates second resolution image, thus obtains Take this second resolution image.

First output section 1205 be judged to by detection unit 1202 evaluation of estimate than predetermined value high in the case of, to high-resolution Image acquiring unit 1102 asks second resolution image, obtains second resolution image from high-definition picture acquisition unit 1102. In addition, this second resolution image is exported and preserves to recording medium 1502 by the first output section 1205.On the other hand, first is defeated Go out portion 1205 in the case of being judged to by detection unit 1202 evaluation of estimate unlike predetermined value height, second resolution image is not exported To recording medium 1502.

(effect)

In the image output device 3001a in such variation, even if obtaining setting of the image of subject The facility applying and observing this image is detached it is also possible to realize the effect same with embodiment 3.

(variation 2)

In the 1st variation in above-mentioned embodiment 3, detection unit 1202 is located at image received device but it is also possible to set In picture transmitter device.Picture transmitter device in 2nd variation possesses detection unit 1202.

Figure 14 is the other of the image processing system of image output device of the 2nd variation illustrating to comprise embodiment 3 The pie graph of example.

Image processing system 300Sb includes：Digit microscope 1500, image output device 3001b, display device 1501 with And recording medium 1502.

Image output device 3001b possesses via communication line interconnective picture transmitter device 3100b and image Reception device 3200b.Additionally, image output device 3001b, as entirety, has the image output device with embodiment 3 3001 same functions.In addition, for example, comprise digit microscope 1500 and the group of picture transmitter device 3100b is configured in The no facility such as hospital of Pathology Doctors '.Comprise the group of image received device 3200b, display device 1501 and recording medium 1502 For example it is configured in away from this hospital, the facility that has Pathology Doctors '.

Picture transmitter device 3100b possesses image acquiring unit 1101 and detection unit 1202.Image acquiring unit 1101 is from number Code microscope 1500 obtains first resolution image, via communication line, by this first resolution image to image received device 3200b sends.Detection unit 1202 obtains the above-mentioned evaluation of estimate association sending from image received device 3200b via communication line Information, derives evaluation of estimate based on this evaluation of estimate related information.In addition, whether detection unit 1202 judges this evaluation of estimate than predetermined value Height, and this result of determination is notified via communication line to image received device 3200b.

Image received device 3200b possesses：High-definition picture acquisition unit 1102, receiving unit 1201 of amplifying, display are with defeated Go out portion 1203 and the first output section 1205.

High-definition picture acquisition unit 1102 according to the request from the first output section 1205, via communication line from image Dispensing device 3100b obtains multiple first resolution images.In addition, high-definition picture acquisition unit 1102 is based on these first point Resolution image and generate second resolution image, thus, obtain this second resolution image.

Evaluation of estimate related information is sent to picture transmitter device 3100b via communication line by display with output section 1203. Thus, carry out the judgement being completed by the detection unit 1202 of picture transmitter device 3100b.

First output section 1205 is certainly in the result of determination confirming to be notified by picture transmitter device 3100b, that is to say, In the case of confirming that evaluation of estimate is higher than predetermined value, ask second resolution image to high-definition picture acquisition unit 1102.In addition, First output section 1205 obtains second resolution image from high-definition picture acquisition unit 1102, will be defeated for this second resolution image Go out and preserve to recording medium 1502.On the other hand, the first output section 1205 is confirming from picture transmitter device 3100b notice Result of determination is negative, that is to say, in the case of confirming evaluation of estimate unlike predetermined value height, not by second resolution image to note Recording medium 1502 exports.

(effect)

So, in this variation, even if detection unit 1202 located at picture transmitter device 3100b it is also possible to realize with upper State embodiment 3 and its same effect of variation 1.

(embodiment 4)

Here, with regard to the digit microscope 1500 of the respective embodiments described above and its variation, below, being said in detail Bright.Additionally, following be referred to as image acquiring device (digital converter (digitizer)) by digit microscope 1500.

In the disclosure, execute and repeatedly shoot the multiple images obtaining using by changing the direction of illumination of illumination light, Form resolution (resolution capability) image higher than each image of these multiple images (hereinafter referred to as " high-definition picture " Or " high resolution image ").Additionally, high-definition picture is suitable with above-mentioned second resolution image, for this high score The multiple images (subimage) of the formation of resolution image are suitable with above-mentioned first resolution image respectively.First, reference picture 15A ～Figure 20, the principle that high-definition picture is formed illustrates.Here, illustrating CCD (Charge Coupled Device：Electricity Lotus coupling element) imageing sensor to be illustrating.Additionally, in the following description, there is substantially the same function sometimes Element represented with common label, and omit the description.

Reference picture 15A and Figure 15 B.Figure 15 A is the top view of the part schematically showing subject.Figure Subject 2 shown in 15A is, for example, the thin slice (typically, having less than tens μm of thickness) of biological tissue.Obtain quilt During the image of reference object 2, subject 2 is closely configured with the shooting face of imageing sensor.Bat from imageing sensor Take the photograph distance to subject 2 for the face and be typically below 1mm, for example, it can be set to being 1 μm about.

Figure 15 B is the light related to the shooting in the region shown in Figure 15 A in the photodiode extract imageing sensor Electric diode and the top view that is schematically indicated.In example described herein, illustrate to be formed at the light of imageing sensor 4 6 photodiodes in electric diode 4p.Additionally, for reference, it is illustrated that representing mutually orthogonal x side in Figure 15 B Arrow to, y direction and z direction.Z direction represents the normal direction in shooting face.In Figure 15 B, also illustrate expression in xy Have rotated, from x-axis, the arrow that the direction after 45 ° is u direction towards y-axis in face.In other accompanying drawings, sometimes illustrate expression x Direction, the arrow in y direction, z direction or u direction.

The element beyond photodiode 4p in imageing sensor 4 is blocked layer and covers.In Figure 15 B, draw shade The region representation of line is blocked the region of layer covering.The sensitive surface of 1 photodiode on the shooting face of ccd image sensor Area (S2) less than the area (S1) of the unit area that comprises this photodiode.Light-receiving area S2 is with respect to the area of pixel The ratio (S2/S1) of S1 is referred to as " aperture opening ratio ".Here, being illustrated with aperture opening ratio for 25%.

Figure 16 A and Figure 16 B schematically shows through subject 2 and is incident to the light of photodiode 4p Direction.Figure 16 A and Figure 16 B represents makes the incident state of light from the direction vertical with shooting face.As Figure 16 A and Figure 16 B In schematically show as, here, be not configured between subject 2 and imageing sensor 4 be imaged lens, The image of subject 2 is obtained using the substantial parallel light through subject 2.

Figure 16 C is shown schematically in image Sa (the 1st subgraph obtain under the direction of illumination shown in Figure 16 A and Figure 16 B As Sa).As shown in figure 16 c, the 1st subimage Sa is constituted by by 6 pixels Pa that 6 photodiode 4p obtain.Each picture Plain Pa has the value (pixel value) representing the light quantity being incident to each photodiode 4p.

As shown in Figure 16 A and Figure 16 B, when irradiating subject 2 from the direction vertical with the face of shooting, pass through quilt The light in the region just gone up in the entirety of reference object 2, being located at photodiode 4p is incident to photodiode 4p.In this example In son, the 1st subimage Sa has in the entirety of subject 2, region A1, A2, A3, A4, A5 and A6 (reference picture 15A) Information.Additionally, the light having passed through the region just gone up not being located at photodiode 4p is not incident to photodiode 4p.Cause This, in the 1st subimage Sa, region beyond in the entirety of subject 2, region A1, A2, A3, A4, A5 and A6 Loss of learning.

Figure 17 A and Figure 17 B illustrates to make light from the irradiation side different from the direction of illumination shown in Figure 16 A and Figure 16 B To incident state.Ray relative shown in Figure 17 A and Figure 17 B tilts to x direction in z direction.Now, passed through and clapped The light taking the photograph the region different from the region just gone up being located at photodiode 4p in the entirety of object 2 is incident to photoelectricity two pole Pipe 4p.

Figure 17 C is shown schematically in acquired image Sb (the 2nd son under the direction of illumination shown in Figure 17 A and Figure 17 B Image Sb).As shown in Figure 17 C, the 2nd subimage Sb is also constituted by by 6 pixels that 6 photodiode 4p obtain.But, Constitute the 2nd subimage Sb pixel Pb have with the entirety of subject 2 in, different from region A1, A2, A3, A4, A5 with And the pixel value of region B1, B2, B3, B4, B5 and B6 (reference picture 15A) correlation of A6.In other words, the 2nd subimage Sb does not have Have in the entirety of subject 2, region A1, A2, A3, A4, A5 and A6 information, instead, have region B1, The information of B2, B3, B4, B5 and B6.Here, such as region B1 is adjacent with the right side of region A1 area in subject 2 Domain (reference picture 15A).

As being appreciated that by comparison diagram 16A and Figure 16 B and Figure 17 A and Figure 17 B, by suitably changing Become direction of illumination, the light in the different region through subject 2 can be made to be incident to photodiode 4p.As a result, the 1st Subimage Sa and the 2nd subimage Sb can comprise the position corresponding Pixel Information different from subject 2.

Figure 18 A and Figure 18 B illustrate to make light from the direction of illumination shown in Figure 16 A and Figure 16 B and Figure 17 A and The incident state of the different direction of illumination of direction of illumination shown in Figure 17 B.Ray relative shown in Figure 18 A and Figure 18 B is in z side To and to y direction tilt.

Figure 18 C is shown schematically in acquired image Sc (the 3rd son under the direction of illumination shown in Figure 18 A and Figure 18 B Image Sc).As shown in figure 18 c, the 3rd subimage Sc is constituted by by 6 pixels Pc that 6 photodiode 4p obtain.As figure Shown, the 3rd subimage Sc has region C1, C2, C3, C4, C5 and the C6 shown in the entirety of subject 2, Figure 15 A Information.Here, such as region C1 is adjacent with the upside of region A1 region (reference picture 15A) in subject 2.

Figure 19 A illustrate to make light from shown in the direction of illumination shown in Figure 16 A and Figure 16 B, Figure 17 A and Figure 17 B The incident state of the different direction of illumination of direction of illumination shown in direction of illumination and Figure 18 A and Figure 18 B.Shown in Figure 19 A Ray relative, in z direction, tilts to the direction with x-axis being in 45° angle in xy face.

Figure 19 B is shown schematically in the image Sd (the 4th subimage Sd) obtain under the direction of illumination shown in Figure 19 A.As Shown in Figure 19 B, the 4th subimage Sd is constituted by by 6 pixels Pd that 6 photodiode 4p obtain.4th subimage Sd has The information of region D1, D2, D3, D4, D5 and the D6 shown in the entirety of subject 2, Figure 15 A.Here, such as region D1 is the region (reference picture 15A) adjacent with the right side of region C1.So, each subimage Sa, Sb, Sc and Sd comprises by quilt The picture that the different part of reference object 2 is constituted.

Figure 20 illustrates by the high-definition picture HR of 4 subimage Sa, Sb, Sc and Sd synthesis.As shown in figure 20, high score The pixel count of resolution image HR or picture element density are the pixel count of each or the pictures of 4 subimages Sa, Sb, Sc and Sd 4 times of plain density.

For example, in concern subject 2, the block of region A1, B1, C1 and the D1 shown in Figure 15 A.From so far it is Explanation only understands, pixel Pa1 of the subimage Sa shown in Figure 20 does not have the overall information of above-mentioned block, and only has area The information of domain A1.Therefore, subimage Sa can be known as the image of the loss of learning of region B1, C1 and D1.

But, by using having subimage Sb, Sc of the position corresponding Pixel Information different from subject 2 And Sd, as shown in figure 20, the information that can be lacked in completion subimage Sa, form the high score with the overall information of block Resolution image HR.The resolution of each subimage is equal with the intrinsic resolution of imageing sensor 4, in contrast, in this embodiment, 4 times of intrinsic resolution of imageing sensor 4 of resolution can be obtained.The degree of high resolution (super image dissection) depends on figure Aperture opening ratio as sensor.In this embodiment, because the aperture opening ratio of imageing sensor 4 is 25%, therefore, by from different 4 The light irradiation in direction, is capable of maximum 4 times of high resolution.When making integer that N is more than 2, if imageing sensor 4 Aperture opening ratio approx equal with 1/N, then maximum is capable of N times of high resolution.

So, irradiate directional light successively from multiple different direction of illuminations on the basis of subject to be taken The shooting of object, the Pixel Information thereby, it is possible to make to sample from subject " spatially " increases.By will be obtained many Individual subimage synthesis, can form the high-definition picture of the high resolution of each than multiple subimages.Certainly, irradiation side To the direction of illumination being not limited to reference picture 16A～Figure 19 B and illustrating.

Additionally, in above-mentioned example, subimage Sa, Sb, Sc and Sd shown in Figure 20 have in subject 2 The Pixel Information in mutually different region, does not have overlap.But it is also possible to there is overlap between different subimages.In addition, In above-mentioned example, same photodiode is all incident to by the light in adjacent 2 regions in subject 2.But It is that the setting of direction of illumination is not limited to this example.For example, clapped it is also possible to be adjusted to pass direction of illumination as shown in figure 21 The light taking the photograph adjacent 2 region of object 2 is incident to different photodiodes respectively.

In the formation of the high-definition picture of the principle based on reference picture 15A～Figure 20 explanation, the acquisition of subimage exists The shooting face of subject 2 and imageing sensor 4 executes in the state of closely configuring.In embodiment of the present disclosure, Using there is subject 2 and the acquisition to carry out subimage for the module of construction that imageing sensor 4 is integrated.With Under, referring to the drawings, one of one of the composition of specification module and the manufacture method of module.

Figure 22 A schematically shows of the cross-sectional configuration of module.In module 10 shown in Figure 22 A, by mounting medium 6 The subject 2 covering configures on the shooting face 4A of imageing sensor 4.In the example in the figures, lamella lucida is (typically Glass plate) 8 configuration on subject 2.That is, in the composition illustrated in Figure 22 A, subject 2 is sandwiched in image and passes Between sensor 4 and lamella lucida 8.If module 10 has lamella lucida 8, operability improves, and is therefore beneficial.As lamella lucida 8, it is, for example possible to use general slide glass.Additionally, in figure, schematically illustrating each key element, the size of the reality of each key element And shape size not necessarily to that indicated in the drawings and shape consistent.Following with reference to other accompanying drawings in be also same 's.

In composition illustrated in Figure 22 A, imageing sensor 4 is fixed on packaging part 5.Figure 22 B illustrates from imageing sensor 4 One of the outward appearance during module 10 shown in Figure 22 A is observed in side.As shown in Figure 22 A and Figure 22 B, packaging part 5 with lamella lucida 8 The face of opposition side has backplate 5B.This backplate 5B is through being formed from wiring pattern (not shown) and the figure of packaging part 5 As sensor 4 electrically connects.That is, the output of imageing sensor 4 can be taken out via backplate 5B.In this manual, will The packaging part structure integrated with imageing sensor is referred to as " capturing element ".

Reference Figure 23, one of the manufacture method of specification module 10.Here, as subject 2, exemplifying biological group The thin slice (tissue slice) knitted.Have biological tissue thin slice be used as the module 10 of subject 2 can be using in pathology In diagnosis.

First, as shown in figure 23, tissue slice A02 is placed in lamella lucida 8.Lamella lucida 8 could be for being shown by optics The slide glass (slide glass) of the observation of the sample that micro mirror is carried out.Hereinafter, as lamella lucida 8, exemplified with slide glass. Then, tissue slice A02 be impregnated in dyeing liquor Ss by each lamella lucida 8, thus, tissue slice A02 is dyeed.Then, to saturating Mounting medium 6 is supplied on isotropic disk 8, accordingly, it is right by being taken obtained from dyeing tissue slice A02 to cover using mounting medium 6 As 2.Mounting medium 6 has the function of protection subject 2.Then, capturing element 7 is configured on subject 2：Figure As the shooting face of sensor 4 is opposed with subject 2.So, obtain module 10.

Module 10 is produced by the object of each shooting.For example under the scene of pathological diagnosis, prepare multiple from 1 corpse or other object for laboratory examination and chemical testing (such as 5～20) tissue slice.Therefore, possesses the mould that the tissue slice obtaining from a same corpse or other object for laboratory examination and chemical testing is used as subject 2 Block 10 can be produced multiple.If the acquisition of multiple subimages is carried out to each of these multiple modules 10, can be with shape Become each the corresponding high-definition picture with multiple modules 10.

As shown in fig. 22, module 10 is different for inspection slide glass from for the observation based on optical microscope, possesses acquisition quilt The imageing sensor 4 of the image of reference object 2.Such module can also be referred to as " electronics is for inspection slide glass ".As Figure 22 A institute Showing, by using there is subject 2 and the module 10 of construction that capturing element 7 is integrated, can obtain consolidating Determine this advantage of configuration between subject 2 and imageing sensor 4.

When executing the acquisition of image of subject 2 using module 10, via lamella lucida 8 to subject 2 Irradiate illumination light.The illumination light having passed through subject 2 is incident to imageing sensor 4.Thus, obtain subject 2 Image.While changing light source and subject relative configuration, execute shooting successively, thereby, it is possible to when irradiating Obtain multiple different images by changing angle.For example, as shown in fig. 24 a, imageing sensor 4 just on configure light source 310.In addition, if the normal direction of the shooting face 4A from imageing sensor 4 for the light CL after collimation is exposed to be taken right As being shot in the state of 2, then can obtain the subimage same with the subimage Sa shown in Figure 16 C.In addition, as Figure 24 B Shown, if the light CL after making collimation in the state of making module 10 tilt exposes to subject 2 and is shot, can To obtain the subimage same with the subimage Sb (or the subimage Sc shown in Figure 18 C) shown in Figure 17 C.So, by one While making module 10 execute shooting successively with respect to the attitudes vibration of light source, one side, reference picture 15A～Figure 20 explanation can be applied Principle is obtaining high-definition picture.

Figure 25 illustrates the outline of of the composition of the image acquiring device of embodiment of the present disclosure.Figure shown in Figure 25 As acquisition device 100a has illuminator 30.In composition illustrated in Figure 25, illuminator 30 comprises：Generate illumination light Light source 31, it is configured to object stage 32 that module 10 can detachably load and is configured to change the appearance of object stage 32 The object stage drive mechanism 33 of state.Figure 25 is shown schematically in the state being filled with module 10 on object stage 32.But, omit Mounting medium 6 in module 10 and the diagram of lamella lucida 8.Module 10 is not that the necessary composition of image acquiring device 100a will Element.

Module 10 has in the state of being connected to object stage 32, is incident to bat through the illumination light after subject 2 Take the photograph the such configuration of element 7.Illuminator 30 for example by making the attitudes vibration of object stage 32, and make with subject 2 be The direction of illumination change of benchmark.The change of " attitude " in this specification widely comprises the change of the inclination with respect to datum level Change, with respect to the change of the anglec of rotation of reference bearing and change of position with respect to datum mark etc..From right to be taken As the multiple different direction of illumination on the basis of 2 irradiates subject 2 successively using the illumination light being generated by light source 31.According to The detailed content of composition of bright system 30 and the example of work are described below.Irradiated by change direction of illumination and be taken Object 2, accordingly obtains different multiple images (subimage) using capturing element 7 and multiple different direction of illuminations.Make With obtained multiple images, high-definition picture can be formed.

Image acquiring device 100a shown in Figure 25 has direction of illumination determination section 40a.This direction of illumination determination section 40a determines Determine the multiple different direction of illumination when obtaining multiple subimage for the capturing element 7.In embodiment of the present disclosure, subimage Obtain under the multiple different direction of illumination being determined by direction of illumination determination section execute.In other words, the enforcement of the disclosure Subimage in mode is and the multiple different corresponding multiple different figures of direction of illumination being determined by direction of illumination determination section Picture.The concrete example of the composition of direction of illumination determination section 40a and work is described below.

Then, reference picture 26A～Figure 27 B, illustrates the direction of illumination of change illumination light on the basis of subject One of method.

Figure 26 A and Figure 26 B illustrates the outward appearance of the illustration of image acquiring device 100a.In composition illustrated in Figure 26 A, Image acquiring device 100a has：The main body 110 that comprises light source 31 and object stage 32, can be opened and closed and main body 110 links Cap 120.By closing cap 120, darkroom (reference picture 26B) can be internally formed in image acquiring device 100a.

In the example in the figures, object stage 32 is connected with the socket 130 for keeping module 10.Socket 130 can be consolidated Due to object stage 32 it is also possible to be configured to load and unload with respect to object stage 32.Here, exemplify socket 130 being configured to Composition with respect to object stage 32 handling.Socket 130 for example comprises：It is configured to the lower substrate 132 that module 10 can be loaded and unloaded；Shape Become to have the upper substrate 134 of peristome Ap.In composition illustrated in Figure 26 A, socket 130 pass through lower substrate 132 with Clip module 10 between portion's base material 134, to keep module 10.

Lower substrate 132 can have electrical connection section, and this electrical connection section has and is electrically connected for the capturing element 7 with module 10 The electric contact connecing.When obtaining the image of subject, module 10 is placed in lower substrate 132, so that capturing element 7 Shooting face is opposed with light source 31.Now, the electric contact of electrical connection section and capturing element 7 backplate 5B (reference picture 22A and Figure 22 B) contact, thus, the capturing element 7 of module 10 and the electrical connection section of lower substrate 132 are electrically connected.

Figure 26 C illustrates of the packing method of object stage 32 that socket 130 is with respect to image acquiring device 100a.In figure In composition illustrated in 26C, socket 130 has the electrode 136 projecting from bottom surface.This electrode 136 can be lower substrate 132 A part for electrical connection section.In addition, in the example shown in Figure 26 C, the object stage 32 of image acquiring device 100a has setting There is the installation portion 34 of jack 36.As shown in Figure 26 C, the socket 130 of state for example maintaining module 10 is with the electrode of socket 130 The mode of 136 insertion jacks 36 fills in object stage 32.Thus, the capturing element 7 in the module 10 being kept by socket 130 and figure As the electrical connection between acquisition device 100a is established.Object stage 32 can have in the socket 130 loading holding module 10 In the state of accept imageing sensor 4 output circuit.In embodiment of the present disclosure, image acquiring device 100a will insert The electrical connection section that seat 130 has to obtain information (picture signal or the figure of the image representing subject 2 as medium As data).

Additionally, it is also possible to prepare and mould in the case of the shooting carrying out multiple subjects using multiple modules 10 The socket 130 of block 10 equal number, changes the right of shooting by changing the socket 130 installing the state maintaining module 10 As.Or it is also possible to be maintained at be installed with object stage 32 1 socket 130 state constant, by change install module 10 Change the object shooting.

As shown in Figure 26 C, by socket 130 is filled in object stage 32, so that the bottom surface of socket 130 and installation portion It is close to above 34.Thus, socket 130 is fixed with respect to the configuration of object stage 32.Therefore, it is possible to the attitude in object stage 32 Change before and after so that object stage 32 and the configuration of the module 10 being held in socket 130 is remained necessarily.Typically, in object stage 32 On be filled with socket 130 in the state of, the interarea of lamella lucida 8 of module 10 is almost parallel with object stage 32.

Figure 27 A illustrates to change one of the method for direction of illumination.As illustrated, shining to the module 10 being held in socket 130 Penetrate illumination light CL projecting from light source 31.Illumination light CL is via the peristome Ap being arranged at socket 130, and is incident to module 10 Subject.It is incident to the shooting face of the capturing element 7 of module 10 through the light after subject.

The light projecting from light source 31, the light after typically collimating.But, can be considered the light being incident to subject In the case of being essentially directional light, the light projecting from light source 31 may not be the light after collimation.

Light source 31 for example comprises LED chip.Light source 31 can also comprise the different wave-length coverage of each leisure and have peak value Multiple LED chips.For example, light source 31 can also comprise to project the blue LED chip of light, project the red LED chip of light, And project the LED chip of the light of green.Make multiple light-emitting components close to (such as 100 μm about) configure in the case of, Point source can be treated them as.

Using multiple light-emitting components of the light projecting mutually different color, for example, will be different by each direction of illumination The light of color is irradiated in a time-sequential manner, thereby, it is possible to obtain the multiple subimages with regard to each color.For example, it is possible to obtain Take the group of the group of blue sub-image, the group of red sub-images and green sub-image.Using the group of acquired subimage, just The high-definition picture of colour can be formed.For example under the scene of pathological diagnosis, by using colored high-definition picture, The more beneficial information with regard to having or not pathological changes etc. can be obtained.As light source 31, using white LED chip, and, in light Light filter is configured, thereby, it is possible to obtain the illumination light of mutually different color in a time-sequential manner on road.In addition, passing as image Sensor 4, it is possible to use the imageing sensor of color camera.But, it is incident to the opto-electronic conversion of imageing sensor 4 from suppression From the viewpoint of the reduction of the light quantity in portion, the composition not configuring light filter is favourable.

Light source 31 is not limited to LED or electric filament lamp, laser component, optical fiber laser, discharge tube etc..From light The light that source 31 is projected is not limited to visible ray or ultraviolet, infrared ray etc..The number of the light-emitting component that light source 31 has Amount and configuration can also arbitrarily set.

As shown in Figure 25 and Figure 27 A, image acquiring device 100a has object stage drive mechanism 33.Object stage driving machine Structure 33 comprises angle measurement (gonio) mechanism, rotating mechanism etc., make object stage 32 with respect to the inclination of main body 110 and/or with regard to By the anglec of rotation change of the axle at the center of object stage 32.Object stage drive mechanism 33 can also comprise to make object stage 32 exist The slide mechanism moving in parallel in datum level (typically horizontal plane).

Worked by making object stage drive mechanism 33, the attitudes vibration of object stage 32 can be made.Here, maintaining module 10 The socket 130 of state be installed on object stage 32, the appearance of module 10 therefore, by making the attitudes vibration of object stage 32, can be made State changes.For example, if the incident direction of illumination light when object stage 32 tilts not with respect to datum level is the bat of imageing sensor Take the photograph the normal direction in face.Here, object stage 32 (also may be used with respect to the inclination of datum level with respect to the inclination of datum level and module 10 To be referred to as the inclination of lamella lucida 8) between the change of attitude in object stage 32 for the relation (for example, parallel) before and after remain one Fixed.Therefore, as shown in figure 27b, when making object stage 32 with respect to datum level tilt angle theta, it is incident to the light of subject The direction of line also tilt angle theta.Additionally, in Figure 27 B, dotted line N illustrates the normal in the shooting face of imageing sensor.

So, the attitude by making module 10 changes together with object stage 32 1, can on the basis of subject 2 from Multiple different direction of illuminations irradiate illumination light to subject successively.Obtain therefore, it is possible to the capturing element 7 using module 10 Take the multiple images corresponding from the multiple different direction of illumination on the basis of subject 2.With subject 2 as base Accurate direction of illumination for example can be by the normal N in the shooting face of imageing sensor and the incident ray institute towards subject 2 The angle (zenith angle θ shown in Figure 27 B) becoming and the reference bearing being set on shooting face shoot face with incident ray direction The group at angle formed by projection (azimuth) is representing.

Additionally, by making light source 31 move in image acquiring device 100a or making configuration at mutually different position Multiple light sources light successively it is also possible to irradiate subjects 2 from multiple different direction of illuminations.For example, by making light source 31 move it is also possible to change direction of illumination along linking the direction that light source 31 is with subject 2.By making the appearance of object stage 32 The change of state is combined with the movement of light source 31 can also to make direction of illumination change.

Additionally, in embodiment of the present disclosure, imageing sensor 4 be not limited to ccd image sensor or CMOS(Complementary Metal-Oxide Semiconductor：Complementary metal oxide semiconductors (CMOS)) imageing sensor Or other imageing sensor (as, following photoelectric conversion film cascade type imageing sensor).Ccd image sensor And cmos image sensor can be any one of surface irradiation type or rear surface irradiation type.Hereinafter, image sensing is described Device element construction and be incident to imageing sensor the light of photodiode relation.

Figure 28 illustrates the example of the cross-sectional configuration of ccd image sensor and the distribution of absorbance Td of the relative of subject Son.As shown in figure 28, ccd image sensor substantially possesses：Insulating barrier 82 on substrate 80, substrate 80, configuration are in insulating barrier 82 Interior wiring 84.It is formed with multiple photodiodes 88 in substrate 80.In wiring 84, it is formed with light shield layer and (does not scheme in Figure 28 Show).Here, eliminating the diagram of transistor etc..Eliminate the diagram of transistor etc. in figures in the following.Additionally, roughly, The cross-sectional configuration near photodiode in the irradiation type cmos image sensor of surface and the photoelectricity two in ccd image sensor Cross-sectional configuration near pole pipe is about same.Therefore, here, eliminating the section of surface irradiation type cmos image sensor The diagram of construction and explanation.

As shown in figure 28, illumination light from shoot face normal direction incidence in the case of, through in subject, Irradiation light after the region R1 just going up of photodiode 88 is incident to photodiode 88.On the other hand, pass through and clapped Take the photograph the shading that the irradiation light after the region R2 just going up of light shield layer in object, being located in wiring 84 is incident to imageing sensor Region (is formed with the region of photomask).Therefore, in the case that the normal direction from the face of shooting is irradiated, obtain representing quilt The image of the region R1 just going up in reference object, being located at photodiode 88.

In order to obtain the image representing the region just gone up being located at photomask, tilt from the normal direction with respect to the face of shooting Direction be irradiated, so that the light having passed through region R2 is incident to photodiode 88.Now, according to direction of illumination Difference, has passed through the part in the light of region R2 and has been blocked by wiring 84 sometimes.In the example in the figures, by with shade The light of the part that line represents does not reach photodiode 88.Therefore, in oblique incidence, pixel value can reduce sometimes. But, it is not being all blocked through light, therefore, it is possible to use the subimage now obtaining is forming high resolution graphics Picture.

Figure 29 A and Figure 29 B represents the cross-sectional configuration of rear surface irradiation type cmos image sensor and the phase of subject To absorbance Td distribution example.As shown in figure 29 a, overleaf in irradiation type cmos image sensor, even if tilting In the case of incidence, also will not be blocked by wiring 84 through light.But, through in subject and want to be shot The light (in Figure 29 A and following Figure 29 B, schematically shown with block arrow BA light) in the different other regions in region It is incident to substrate 80, thus can produce noise, the quality of subimage is possible to deteriorate.As shown in fig. 29b, this deterioration can be led to Cross and light shield layer 90 is formed on the region being formed with beyond the region of photodiode on substrate to reduce.

(below, Figure 30 illustrates to possess the imageing sensor of the photoelectric conversion film being formed by organic material or inorganic material The distribution of cross-sectional configuration referred to as " photoelectric conversion film cascade type imageing sensor ") and subject relative absorbance Td Example.

As shown in figure 30, photoelectric conversion film cascade type imageing sensor substantially has：Substrate 80, it is provided with multiple pixels electricity Transparency electrode 96 in photoelectric conversion film 94 on the insulating barrier 82 of pole, insulating barrier 82, photoelectric conversion film 94.As illustrated, In photoelectric conversion film cascade type imageing sensor, replace being formed at the photodiode of semiconductor substrate, and in substrate 80 (for example Semiconductor substrate) above form the photoelectric conversion film 94 carrying out opto-electronic conversion.Photoelectric conversion film 94 and transparency electrode 96 are typically Formed throughout shooting the entirety in face.Here, eliminating the diagram of the protecting film of protection photoelectric conversion film 94.

In photoelectric conversion film cascade type imageing sensor, incident illumination in photoelectric conversion film 94 by opto-electronic conversion The electric charge (electronics or hole) producing concentrates on pixel electrode 92.Thus, obtain representing the light being incident to photoelectric conversion film 94 The value of amount.Therefore, in photoelectric conversion film cascade type imageing sensor it may be said that in shooting face, comprise 1 pixel electrode 92 unit area is suitable with 1 pixel.In photoelectric conversion film cascade type imageing sensor, even if with rear surface irradiation type Cmos image sensor, similarly in the case of oblique incidence, also will not be blocked by wiring through light.

As illustrated by reference picture 15A～Figure 20, in the formation of high-definition picture, using representing by being taken Multiple subimages of the picture that the different part of object is constituted.However, in typical photoelectric conversion film cascade type imageing sensor In, throughout shoot face photoelectric conversion film 94 is integrally formed, even if thus, for example in the case of vertical incidence it is also possible to by Light through the region beyond the desired region of subject produces opto-electronic conversion in photoelectric conversion film 94.If now producing Unnecessary electronics or hole be introduced into pixel electrode 92 it is likely that cannot suitable subimage.Therefore, will be in picture The electric charge producing in plain electrode 92 region overlapping with transparency electrode 96 (region with oblique line in Figure 30) is selectively introduced Pixel electrode 92 is beneficial.

In composition illustrated in Figure 30, with pixel electrode 92 each accordingly, be provided with dummy electrode in pixel 98.When obtaining the picture of subject, between pixel electrode 92 and dummy electrode 98, provide suitable potential difference.Thus, The electric charge producing in region beyond the region overlapping with transparency electrode 96 in pixel electrode 92 can be introduced to dummy electrode 98, the electric charge producing in the region overlapping with transparency electrode 96 in pixel electrode 92 can be selectively introduced pixel electrode 92.Additionally, by the patterning of transparency electrode 96 or photoelectric conversion film 94 it is also possible to obtain same effect.Such It may be said that the ratio (S3/S1) with respect to the area S1 of pixel for the area S3 of pixel electrode 92 and " aperture opening ratio " phase in composition When.

As already described, when setting the integer as more than 2 for the N, if the aperture opening ratio of imageing sensor 4 approx with 1/N is equal, then can realize maximum N times of high resolution.In other words, aperture opening ratio is little is favourable to high resolution.? In photoelectric conversion film cascade type imageing sensor, by adjusting the area S3 of pixel electrode 92, can adjust suitable with aperture opening ratio Ratio (S3/S1).This ratio (S3/S1) is for example set to 10%～50% scope.Ratio (S3/S1) is in above-mentioned model Photoelectric conversion film cascade type imageing sensor in enclosing can be used for super image dissection.

Additionally, knowable to Figure 28 and Figure 29 B, in ccd image sensor and surface irradiation type cmos image sensor In, the surface opposed with subject is not flat.For example, in ccd image sensor, there is height in its surface Difference.In addition, overleaf in irradiation type cmos image sensor, for obtaining the subimage for forming high-definition picture, needing The light shield layer of patterning is arranged on shooting face, the surface opposed with subject is not flat.

On the other hand, as can be seen from Figure 30, the shooting face of photoelectric conversion film cascade type imageing sensor is almost flat face. Therefore, even if in the case of being configured with subject on shooting face, also it is nearly free from the shape in the shooting face of resulting from The deformation of subject.In other words, subimage, Neng Gouguan are obtained by using photoelectric conversion film cascade type imageing sensor Examine the more detailed construction of subject.

More than, based on several embodiments, the image output device involved by one or more mode is said Bright, but the present invention is not limited to these embodiments.Without departing from the purport of the present invention, this area is implemented to present embodiment Technical staff mode obtained by the thinkable various modifications and/or element in different embodiments is combined And the mode constructed can also be contained in the disclosure.

Additionally, in the respective embodiments described above, each element can be constituted using special hardware, or by execution It is suitable to the software program of each element to realize.Each element can also pass through the program execution department such as CPU or processor Read the software program recorded in the recording medium such as hard disk or semiconductor memory (ordering) and execute to be realized. Here, the software realizing the image output device of the respective embodiments described above etc. be make computer execute Fig. 3, Fig. 4, Fig. 7, Fig. 9 or The program of each step in the flow chart of person Figure 11.Additionally, program execution department can be made up of it is also possible to by many 1 processor Individual processor is constituted.

In addition, in the disclosure, unit, all or part of device or Fig. 1, Fig. 5, Fig. 6, Fig. 8, Figure 10, with And all or part of the functional device of the block diagram shown in Figure 12～Figure 14 can be integrated by comprising semiconductor device, quasiconductor Circuit (IC) or LSI (large scale integration：Large scale integrated circuit) one or more than one Electronic circuit is executing.LSI or IC can be integrated in a chip it is also possible to constitute multiple chip portfolios.For example, deposit Functional device beyond storage element can be integrated in a chip.Here, being referred to as LSI or IC, but, according to integrated degree Difference, title method can change, and may be referred to as system LSI, VLSI (very large scale integration；Ultra-large Integrated circuit) or ULSI (ultra large scale integration；ULSI).Also can be with phase Same purpose is using the Field Programmable Gate Array (FPGA of programming after the manufacture of LSI：Field-programmable Gate array) or the reconfigurable logic device that the engagement relationship within LSI or the circuit within setting LSI divide can be reconstructed.

Additionally, the function of a part for unit, device or device, all or part or operation can be passed through Software processes are executing.In this case, software is recorded in one or more than one ROM, CD, hard disk drive etc. The recording medium of non-transitory, in the case that software is by processing meanss (processor) execution, software makes processing meanss (processor) the specific function and in the device execution software of periphery.System or device can also possess record have soft The recording medium of one of part or more than one non-transitory, processing meanss (processor) and necessitate hard Part device such as interface.

The disclosure has this effect of burden of the process that can mitigate high-definition picture, for instance, it is possible to be applied to locate Image output device of high-definition picture of a reason pathology corpse or other object for laboratory examination and chemical testing etc..

Claims

1. a kind of image output device, possesses：

At least one processor；With

Keep the non-transitory recording medium of order,

Described order makes at least one computing device described：

Obtain first resolution image, described first resolution image is to be taken based on obtained from the shooting of digit microscope The image of object；

Obtain second resolution image, described second resolution image is that first resolution image described in resolution ratio is high, base Image in subject described obtained from the shooting of described digit microscope；

Accept the amplification for the described first resolution image shown by display device；

Judge whether the evaluation of estimate based on the described amplification being accepted is higher than predetermined value；

In the case that evaluation values are higher than described predetermined value being judged to, send described second resolution figure to external device (ED) Picture, in the case that evaluation values are unlike described predetermined value height being judged to, does not send described second point to described external device (ED) Resolution image.

2. image output device according to claim 1,

Described order also makes at least one computing device described：

In the case that evaluation values are unlike described predetermined value height being judged to, send described first resolution to described external device (ED) Rate image.

3. image output device according to claim 1 and 2,

Described order also makes at least one computing device described：

In the case that being judged to, evaluation values are higher than described predetermined value, described second resolution image is exported and preserves to Recording medium, in the case that being judged to, evaluation values are unlike described predetermined value height, not described to the output of described recording medium Second resolution image.

4. image output device according to claim 1 and 2,

Described order also makes at least one computing device described：

The amplification deriving the maximum in one or more the described amplification being accepted is used as institute's evaluation values.

5. image output device according to claim 1 and 2,

Described order also makes at least one computing device described：

The number of times accepting high amplification as the amplification higher than threshold value in the accepting of described amplification is more or described The time that the image of subject is shown in described display device with described high amplification is longer, then derive higher institute's commentary It is worth.

6. image output device according to claim 1 and 2,

Described order also makes at least one computing device described：

The area being shown in the described subject of described display device with the described amplification higher than threshold value is bigger, then calculate Higher institute's evaluation values.

7. image output device according to claim 1,

Described first resolution image is the first first resolution image,

Described order makes at least one computing device described：Obtain the second first resolution image, described the two the first differentiate Rate image is the image of the described subject obtained from shooting based on described digit microscope,

Described second resolution image is based on described first first resolution image and described second first resolution image and gives birth to Become,

Described digit microscope send with described subject be in the 1st angle the 1st light and with described subject be in the 2nd 2nd light of angle, sends described 2nd light after sending described 1st light, and described digit microscope is based on the 1st many pixel values Generate described first first resolution image, generate described second first resolution image based on the 2nd many pixel values,

The quantity of the quantity of the pixel value of described second resolution image pixel value more than the described 1st is many, and, described second The quantity of the quantity of the pixel value of image in different resolution pixel value more than the described 2nd is many,

Described subject comprises part 1 and the part 2 adjacent with described part 1,

Multiple photoelectric conversion parts are based on described 1st light and pass through the 1st conversion light obtained from described subject, export and comprise the The described 1st many pixel values of 1 pixel value, based on described 2nd light by the 2nd conversion light obtained from described subject, Output comprises the described 2nd many pixel values of the 2nd pixel value,

The plurality of photoelectric conversion part comprises the 1st photoelectric conversion part and 2nd opto-electronic conversion adjacent with described 1st photoelectric conversion part Portion,

Described 1st photoelectric conversion part based on the part in described 1st light by obtained from described part 1, described 1st turn Change a part for light, export described 1st pixel value,

Described 2nd photoelectric conversion part based on the part in described 2nd light by obtained from described part 2, described 2nd turn Change a part for light, export described 2nd pixel value.

8. a kind of image output device, is had picture transmitter device and is connected with described image dispensing device via communication line Image received device,

Described image dispensing device possesses：

At least one transmission processor；With

Keep the non-transitory transmission recording medium of transmission order,

Described transmission order makes at least one transmission computing device described：

Obtain first resolution image and send to described image reception device, described first resolution image is based on digital aobvious The image of subject obtained from the shooting of micro mirror；

Judge whether the evaluation of estimate representing by the evaluation of estimate related information being notified by described image reception device is higher than predetermined value；

In the case that evaluation values are higher than described predetermined value being judged to, send described second point to described image reception device Resolution image,

Described image reception device possesses：

At least one reception processor；With

Keep the non-transitory reception recording medium of reception order,

Described reception order makes at least one reception computing device described：

Obtain described first resolution image from described image dispensing device and make it be shown in display device；

Accept the amplification for the described first resolution image shown by described display device；

Based on the described amplification being accepted, the described first resolution image shown by described display device is amplified；

Send the institute's evaluation values related information based on the described amplification being accepted to described image dispensing device.

9. a kind of image output device, is had picture transmitter device and is connected with described image dispensing device via communication line Image received device,

Described image dispensing device possesses：

At least one transmission processor；With

Keep the non-transitory transmission recording medium of transmission order,

Obtain second resolution image, described second resolution image is that first resolution image described in resolution ratio is high, base In the image of subject described obtained from the shooting of described digit microscope, described image reception device possesses：

At least one reception processor；With

Keep the non-transitory reception recording medium of reception order,

Judge whether the evaluation of estimate based on the described amplification being accepted is higher than predetermined value, and result of determination is notified to described figure As dispensing device,

The described transmission order of described image dispensing device also makes at least one transmission computing device described：

Represent institute's evaluation values situation higher than described predetermined value in the described result of determination being notified by described image reception device Under, send described second resolution image to described image reception device.

10. image output device according to claim 8 or claim 9,

Described transmission order also makes at least one transmission computing device described：

In the judgement of institute's evaluation values, in the case that being judged to, evaluation values are unlike described predetermined value height, by described the Two image in different resolution export and preserve to recording medium.

A kind of 11. image output methods, including：

A kind of 12. image received devices, are connected with picture transmitter device via communication line,

Described image dispensing device possesses：

At least one transmission processor；With

Keep the non-transitory transmission recording medium of transmission order,

Judge whether the evaluation of estimate representing by the evaluation of estimate related information being notified by image received device is higher than predetermined value；

Described image reception device possesses：

At least one reception processor；With

Keep the non-transitory reception recording medium of reception order,

A kind of 13. image received devices, are connected with picture transmitter device via communication line,

Described image dispensing device possesses：

At least one transmission processor；With

Keep the non-transitory transmission recording medium of transmission order,

Obtain second resolution image, described second resolution image is that first resolution image described in resolution ratio is high, base In the image of subject described obtained from the shooting of described digit microscope,

Described image reception device possesses：

At least one reception processor；With

Keep the non-transitory reception recording medium of reception order,

Represent institute's evaluation values situation higher than described predetermined value in the described result of determination being notified by described image reception device Under, described second resolution image is sent to described image reception device.

A kind of 14. picture transmitter devices, are connected with image received device via communication line,

Described image reception device possesses：

At least one reception processor；With

Keep the non-transitory reception recording medium of reception order,

Obtain first resolution image from described image dispensing device and make it be shown in display device, described first resolution figure It seem the image based on subject obtained from the shooting of digit microscope；

To be sent to described image dispensing device based on the evaluation of estimate related information of the described amplification being accepted,

Described image dispensing device possesses：

At least one transmission processor；With

Keep the non-transitory transmission recording medium of transmission order,

Obtain described first resolution image and send to described image reception device；

Judge the evaluation of estimate representing by the institute's evaluation values related information being notified by described image reception device whether than predetermined Value is high；

In the case that being judged to, evaluation values are higher than described predetermined value, described second resolution image is sent to described figure As reception device.

A kind of 15. picture transmitter devices, are connected with image received device via communication line,

Described image reception device possesses：

At least one reception processor；With

Keep the non-transitory reception recording medium of reception order,

Described image dispensing device possesses：

At least one transmission processor；With

Keep the non-transitory transmission recording medium of transmission order,