CN106469449B - Method and device for displaying focus in medical image - Google Patents
Method and device for displaying focus in medical image Download PDFInfo
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- CN106469449B CN106469449B CN201610791796.6A CN201610791796A CN106469449B CN 106469449 B CN106469449 B CN 106469449B CN 201610791796 A CN201610791796 A CN 201610791796A CN 106469449 B CN106469449 B CN 106469449B
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- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
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- G06T2207/00—Indexing scheme for image analysis or image enhancement
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- G06T2207/10088—Magnetic resonance imaging [MRI]
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- G06T2207/30—Subject of image; Context of image processing
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Abstract
The invention discloses a method and a device for displaying a focus in a medical image, wherein the display method comprises the following steps: acquiring a plurality of medical images of the same layer of a focus area; carrying out image registration on the reference image and the non-reference image; carrying out image subtraction on the reference image and the non-reference image after the image registration to obtain a subtracted image; displaying the subtraction image. The technical scheme of the invention discloses a method for highlighting a focus by subtracting a plurality of images of a patient, which can accurately display the position and the size of the focus, is convenient for a doctor to quickly check and carry out the diagnosis of the focus.
Description
Technical Field
The invention relates to the field of medical images, in particular to lesion display of medical images.
Background
In the field of medical images, lesion regions in the images are typically highlighted by advanced post-processing of the medical images, facilitating the physician to find the lesions hidden in the images for clinical diagnosis.
A method of image processing is proposed, for example in US patent application US20020090126, to detect an abnormal development area by image subtraction. In the image preprocessing, the focus is amplified by a morphological method, so that the highlighted shadow is automatically detected in the subtraction image.
An image processing apparatus is proposed in US patent application US20040101188, also relating to image subtraction processing. The specific image preprocessing mode is as follows: and performing affine global registration during the first registration, performing target segmentation on the image during the second registration, and performing nonlinear registration to obtain a subtraction image.
However, in the case of a liver, it is difficult to find a lesion in an image by a conventional method because of low contrast between tissues. Especially for some lesions, viewing only a single image or comparing two images does not facilitate the doctor to determine the exact size of the lesion area, and also increases the time for the doctor to view the lesion.
Disclosure of Invention
The invention provides a method and a device for displaying a focus in a medical image, which are used for solving at least one problem in the prior art.
In order to solve the above problems, the present invention provides a method for displaying a lesion in a medical image, comprising: acquiring a plurality of medical images of the same layer of a focus area; the plurality of medical images are acquired at different times; taking one medical image of the plurality of medical images as a reference image, taking the medical images except the reference image as non-reference images, and carrying out image registration on the reference image and the non-reference images to obtain non-reference images after image registration; carrying out image subtraction on the reference image and the non-reference image after the image registration to obtain a subtracted image; displaying the subtraction image.
Preferably, the focal region is the liver.
Preferably, the plurality of medical images are medical images of a plurality of phases obtained based on a dynamic enhanced scan.
Preferably, the plurality of medical images includes any two of: a sweep phase image, an arterial phase image, a venous phase image, and a delay phase image.
Preferably, the plurality of medical images includes a flat scan period image, an arterial period image, a venous period image, and a delayed period image. Preferably, the reference image is an arterial phase image.
Preferably, the displaying the subtraction image further includes: and displaying the non-reference image after the image registration. Preferably, the registered non-reference image is displayed by using a chessboard fusion display or pseudo-color fusion display method.
Preferably, the medical image is a magnetic resonance image or a computed tomography image.
In order to solve the above problems, the present invention also provides a display device of a lesion in a medical image, comprising: the acquiring unit is used for acquiring a plurality of medical images of the same layer of the focus area; the plurality of medical images are acquired at different times; a registration unit, configured to perform image registration on one of the plurality of medical images as a reference image and the medical images except the reference image as non-reference images, and obtain non-reference images after image registration; the subtraction unit is used for carrying out image subtraction on the reference image and the non-reference image after the image registration to obtain a subtracted image; a display unit for displaying the subtraction image.
Compared with the prior art, the technical scheme of the invention discloses a method for highlighting the focus by subtracting a plurality of images of a patient, which can accurately display the position and the size of the focus, is convenient for a doctor to quickly check and carries out the diagnosis of the focus.
Drawings
FIG. 1 is a block diagram of a medical imaging device according to an embodiment of the present invention;
FIG. 2 is a flow chart of a method for displaying a lesion in a medical image according to an embodiment of the present invention;
FIG. 3 is a graph showing the change in drug concentration over time;
FIG. 4 is a schematic representation of a quaternary image of a liver according to an embodiment of the present invention;
FIG. 5 is a schematic diagram of liver image registration fusion according to an embodiment of the present invention;
FIG. 6 is a schematic representation of a subtracted image of a quaternary image of a liver according to an embodiment of the present invention;
fig. 7 is a schematic structural diagram of a medical image lesion display apparatus according to an embodiment of the present invention.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, specific details are set forth in order to provide a thorough understanding of the present invention. The invention can be implemented in a number of ways different from those described herein and similar generalizations can be made by those skilled in the art without departing from the spirit of the invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.
Fig. 1 is a structural diagram of a medical Imaging apparatus, and a Magnetic Resonance scanning apparatus (MR) is taken as an example for illustration. Referring to fig. 1, a magnetic resonance scanning apparatus 100 generally includes three sections, a gantry 101, a couch 102, and a console 103 for operation by a physician. The console 103 may typically include a computer that controls the imaging side for scanning and a computer of an image advanced post-processing workstation. In scan imaging, a patient lies on the scanning bed 102, and the scanning bed 102 pushes the patient into the bore of the gantry 101. A radio frequency receiving coil in the gantry 101 receives a radio frequency signal emitted by a patient, and a subsequent link of the radio frequency receiving coil transmits acquired radio frequency signal data to the console 103 for preliminary data processing and image reconstruction to form an MR image. The MR image can be subjected to advanced post-processing of the image in an image advanced post-processing workstation, and the obtained image and related auxiliary information are convenient for diagnosis of doctors. The medical imaging device may also be a Computed Tomography (CT) device, and the CT device acquires data of a patient and reconstructs the acquired data to obtain a Computed tomography image.
The technical scheme of the display method of the focus in the medical image is shown in figure 2, and comprises the following steps:
step S201, a plurality of medical images of the same layer of the focus area are obtained. The plurality of medical images are acquired at different time instants, and may be medical images of a plurality of time phases obtained based on a dynamic enhanced scan, which is described in detail in the following section.
In magnetic resonance scanning, a focal region (e.g., brain, lung, liver) is scanned and imaged, and then a three-dimensional image of the focal region is reconstructed.
For some organs with low intrinsic contrast, for example, the liver belongs to a solid organ, the natural contrast is not good. In particular, in the case of chronic liver diseases, the liver is often subject to steatosis, so that the lipid content is high, and in addition, the liver has dual blood supply, which makes the analysis of blood supply of liver parenchyma and focus difficult. Therefore, for detecting liver lesions, especially liver tumors or tumor-like lesions, the conventional MRI flat scan is not effective, and dynamic enhanced scanning is usually performed. Dynamic enhanced scanning is the acquisition of medical images at multiple times in the time axis with contrast agents.
Liver enhancement scans can use ionic or non-ionic interstitial contrast agents (e.g., Marugenow, Magnetoglutamine, and Europe, etc.), as well as the dual phase contrast agent, Modisco. The standard dose is 0.1mmol (i.e. 0.2ml) per kg body weight, and the adult dose is usually about 15 ml.
For liver motion enhancement scans, the phases of the image typically used for observation are: a flat scan phase image (i.e., a normal scan image), an arterial phase image, a venous phase image, and a delayed phase image. In the normal case of circulation, as shown in fig. 3, fig. 3 is a graph showing the change of the concentration of the drug with time after the drug is injected into the human body, reflecting the change of the concentration of the drug in each time phase. The hepatic artery phase is a scan that in principle places the acquisition time of the K-space central data 10-20 seconds after the start of the injection of contrast agent. The arterial phase time is adjusted accordingly according to the scanning sequence. While the portal phase is typically scanned 30-45 seconds after the start of the contrast media injection, and the delay period is typically 1-2 minutes after the start of the contrast media injection. And as for the image signal, the data information of the arterial phase image is most abundant, followed by the venous phase, the delay phase. FIG. 4 is a schematic view of acquired flat scan, arterial, venous, and delay phase images.
Step S202, regarding one of the plurality of medical images acquired in step S201 as a reference image, performing image registration on the medical image (i.e., a non-reference image) except the reference image and the reference image, and obtaining the non-reference image after the image registration. Here, the image registration may be rigid registration or non-rigid registration. The rigid body registration has the advantages that only parameters such as translation, rotation and the like are considered, so that the registration speed is high and the time is short. For non-rigid registration, more image deformation factors are considered on the basis of rigid registration, so that the image registration is more accurate.
The embodiment of the invention preferably adopts the artery phase image as the reference image. This is because the arterial phase image is at the time of highest drug concentration, and the data information of the blood vessel and surrounding tissues is the most abundant, so that the result is more accurate when the image is used for registration. Fig. 5 is a schematic diagram of registration of an arterial phase image as a reference image and a sweep phase, venous phase, and delay phase image as a non-reference image. The registration of the cross section and the coronal plane are respectively shown in the figure and displayed in the form of chessboard registration, and it can be seen that the registration result is more accurate when the arterial phase image is taken as a reference image.
In other embodiments of the invention, other phase (sweep, venous, delay) images may be used as reference images, except that the registration results are slightly worse than when arterial as reference images.
In other embodiments of the present invention, the display of the registered images may also be in the form of pseudo-color images.
And step S203, carrying out image subtraction on the reference image and the non-reference image after the image registration to obtain a subtracted image. Here, the reference image (e.g., arterial phase image) and the non-reference image (pan phase, venous phase, and delay phase image) are image-subtracted and displayed at the console 103.
Fig. 6 is a schematic diagram of a post-registration subtraction display performed with an arterial phase image as a reference image. Here, the case of the subtraction images of the cross-sectional and coronal images, respectively, is shown, with the tumor positions indicated by white arrows.
And step S204, displaying the subtraction image for the doctor to check, quickly positioning the position and size of the tumor and facilitating subsequent diagnosis. Here, the registration images, such as fig. 5, may also be displayed simultaneously, so as to facilitate the checking of the registration effect, and when the registration result is considered reliable, it may be inferred that the subtraction result is also more accurate.
In other embodiments of the invention, images of only two or three phases may be relied upon for registration and subtraction. For example, only the scan results in the image of the scout phase, the artery phase and the vein phase, wherein the image of the artery phase is taken as the reference image for the subtraction after the registration.
In other embodiments of the present invention, images of four phases need to be registered and subtracted simultaneously, providing richer diagnostic information. For example, for the diagnosis of liver tumor, liver cirrhosis, fatty liver, etc., in which the subtraction of the artery phase and the flat scan phase can make the tissue supplied by artery appear prominently for liver tumor lesion, and the subtraction of the vein phase data and the artery phase data (or flat scan phase) can make the vein supplied blood tissue appear prominently, the doctor can judge the lesion degree and the treatment effect of the tumor through the specific tumor supply relationship.
The invention mainly aims at a display method of focus at liver, because the liver has double blood supply, the liver blood supply is very rich, and the blood volume of the liver is equal to 14 percent of the total amount of a human body, wherein 1/4 of the liver blood supply is from a hepatic artery, 3/4 of the liver blood supply is from a portal vein, the hepatic artery is from arterial blood of a heart and mainly supplies oxygen, and the portal vein collects venous blood of a digestive tract and mainly supplies nutrition.
On the basis of the medical image focus display method of the present invention, a display device of a focus in a medical image is also disclosed, as shown in fig. 7, the medical image focus display device 700 includes:
an obtaining unit 701, configured to obtain multiple medical images of a same layer of a lesion area; the plurality of medical images are acquired at different times.
A registering unit 702, configured to perform image registration on one of the plurality of medical images as a reference image and the medical images except the reference image as non-reference images, so as to obtain non-reference images after image registration.
A subtraction unit 703, configured to perform image subtraction on the reference image and the non-reference image after the image registration to obtain a subtracted image.
A display unit 704 for displaying the subtracted image.
The specific implementation manners of the obtaining unit 701, the registering unit 702, the subtraction unit 703 and the displaying unit 704 may refer to the implementation manner of the medical image lesion displaying method, and are not described in detail herein.
The technical scheme of the invention discloses a method for highlighting a focus by subtracting a plurality of images of a patient, which can accurately display the position and the size of the focus, is convenient for a doctor to quickly check and carry out the diagnosis of the focus.
Although the present invention has been described with reference to the preferred embodiments, it is not intended to limit the present invention, and those skilled in the art can make variations and modifications of the present invention without departing from the spirit and scope of the present invention by using the methods and technical contents disclosed above.
Claims (9)
1. A method for displaying a lesion in a medical image, comprising:
acquiring a plurality of medical images of the same layer of a focus area; the plurality of medical images are acquired at different times;
taking one medical image of the plurality of medical images as a reference image, taking the medical images except the reference image as non-reference images, and carrying out image registration on the reference image and the non-reference images to obtain non-reference images after image registration;
carrying out image subtraction on the reference image and the non-reference image after the image registration to obtain a subtracted image;
displaying the subtraction image;
the plurality of medical images are medical images of a plurality of time phases obtained based on a dynamic enhanced scan.
2. The method of claim 1, wherein the focal region is the liver.
3. The method of claim 1, wherein the plurality of medical images include any two of: a sweep phase image, an arterial phase image, a venous phase image, and a delay phase image.
4. The method of claim 1, wherein the plurality of medical images comprises a sweep phase image, an arterial phase image, a venous phase image, and a delay phase image.
5. The method of claim 3, wherein the reference image is an arterial phase image.
6. The method of claim 1, wherein said displaying said subtracted image further comprises: and displaying the non-reference image after the image registration.
7. The method of claim 6, wherein the registered non-reference images are displayed using a checkerboard fusion display or a pseudo-color fusion display.
8. The method of claim 1, wherein the medical image is a magnetic resonance image or a computed tomography image.
9. A device for displaying a lesion in a medical image, comprising:
the acquiring unit is used for acquiring a plurality of medical images of the same layer of the focus area; the plurality of medical images are acquired at different times;
a registration unit, configured to perform image registration on one of the plurality of medical images as a reference image and the medical images except the reference image as non-reference images, and obtain non-reference images after image registration;
the subtraction unit is used for carrying out image subtraction on the reference image and the non-reference image after the image registration to obtain a subtracted image;
a display unit for displaying the subtraction image;
the plurality of medical images are medical images of a plurality of time phases obtained based on a dynamic enhanced scan.
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| CN107067420A (en) * | 2017-04-28 | 2017-08-18 | 上海联影医疗科技有限公司 | Image processing method, device and equipment |
| CN107451983A (en) * | 2017-07-18 | 2017-12-08 | 中山大学附属第六医院 | The three-dimensional fusion method and system of CT images |
| CN107767444A (en) * | 2017-11-06 | 2018-03-06 | 上海联影医疗科技有限公司 | A kind of method and device of image procossing |
| CN109840898A (en) * | 2017-11-24 | 2019-06-04 | 通用电气公司 | A kind of the imaging display methods and imaging device of medical image |
| CN108433755A (en) * | 2018-04-13 | 2018-08-24 | 河南科技大学第附属医院 | A kind of tumor sampling device |
| CN109859679A (en) * | 2018-12-14 | 2019-06-07 | 青岛海信医疗设备股份有限公司 | Medical display device and medical image display method |
| CN110211089A (en) * | 2019-04-23 | 2019-09-06 | 中国科学院深圳先进技术研究院 | Extracting method, device and the storage medium of clear cell carcinoma of kidney transfer judging characteristic |
| CN112767370B (en) * | 2020-05-28 | 2024-02-20 | 福州宜星大数据产业投资有限公司 | Target region labeling method based on image registration |
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| CN101652100A (en) * | 2007-03-29 | 2010-02-17 | 皇家飞利浦电子股份有限公司 | Be used to obtain the method and apparatus of fusion x-ray images |
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Address after: 201807 No. 2258 Chengbei Road, Jiading Industrial Zone, Jiading District, Shanghai. Patentee after: Shanghai Lianying Medical Technology Co., Ltd Address before: 201807 No. 2258 Chengbei Road, Jiading Industrial Zone, Jiading District, Shanghai. Patentee before: SHANGHAI UNITED IMAGING HEALTHCARE Co.,Ltd. |
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