CN106370715A - Blood component analysis method and blood component analysis apparatus - Google Patents

Blood component analysis method and blood component analysis apparatus Download PDF

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Publication number
CN106370715A
CN106370715A CN201510429981.6A CN201510429981A CN106370715A CN 106370715 A CN106370715 A CN 106370715A CN 201510429981 A CN201510429981 A CN 201510429981A CN 106370715 A CN106370715 A CN 106370715A
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China
Prior art keywords
blood sample
electrode
time period
preset time
current
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CN201510429981.6A
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Chinese (zh)
Inventor
张容祥
禹炳煜
蔡忠烈
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EMPECS MEDICAL DEVICE Co Ltd
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EMPECS MEDICAL DEVICE Co Ltd
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Priority to CN201510429981.6A priority Critical patent/CN106370715A/en
Publication of CN106370715A publication Critical patent/CN106370715A/en
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  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

The present invention provides a blood component analysis method and a blood component analysis apparatus. According to the method, the hematocrit value of a current blood sample is determined through the current change within a preset time period, wherein the current change is obtained by connecting an electrode pair placed in the current blood sample to a power supply; and the correcting value is generated by using the hematocrit value, and the original analysis result of the current blood sample components is corrected by using the correcting value, such that the interference of the hematocrit value on the analysis result of the component to be analyzed can be reduced so as to improve the precision of the analysis result. According to the present invention, with the method and the apparatus of the embodiment, the hematocrit value can be obtained by measuring the current change rate in the current blood sample within the preset time period, such that the method is easy to achieve compared with the method using the reduction of the interference of the hematocrit value on the analysis result in the prior art so as to reduce the complexity of the blood component analysis process.

Description

A kind of blood component analyzing method and device
Technical field
The application is related to detection and analysis field, more particularly, to a kind of blood component analyzing method and device.
Background technology
During the special component in analysis blood, the hematocrit of blood can reduce analysis result Precision.At present, in order to reduce hematocrit for the impact of testing result it is common practice to incite somebody to action Blood cell separates from blood, or uses chemical addition agent or physical removal ion.
And in practical operation, the complexity of aforesaid way is higher, and blood component analyzing is led to have relatively High complexity.
Content of the invention
This application provides a kind of blood component analyzing method and device are it is therefore intended that solve existing blood The high problem of component analyzing method complexity.
To achieve these goals, this application provides technical scheme below:
A kind of blood component analyzing method, comprising:
Obtain the original analysis result of blood constituent;
According to the rate of change of electric current in preset time period, determine the hematocrit in described current blood sample Value, described electric current is by acquisition that the electrode being placed in described current blood sample is switched on power;
Using described compensating value, described original analysis result is maked corrections, described compensating value is according to described Hematocrite value generates.
Alternatively, the variable quantity of described foundation electric current in preset time period, determines in described current blood sample Hematocrite value include:
Access predeterminated voltage for the first electrode that is placed in described current blood sample so that in the described first electricity Form concentration difference, described concentration difference is used in institute between pole and other electrodes of being placed in described current blood sample State generation electric current in current blood sample;
Detect in described preset time period, the variable quantity of the electric current in described blood sample;
Calculate rate of change in described preset time period for the described variable quantity;
According to the Changing Pattern of hematocrit curve, determine that the corresponding hematocrit of described rate of change is bent Line;
According to described hematocrit curve, determine the hematocrite value in described current blood sample.
Alternatively, the quantity at least one of described other electrode.
Alternatively, described preset time period includes:
From to the moment of described electrode input voltage to the first predetermined time;
Or, from the second predetermined time to the 3rd predetermined time.
Alternatively, described electrode includes:
Carbon-containing electrode, conductor electrode, semi-conducting electrode or insulator electrode.
A kind of blood component analyzing device, comprising:
Acquisition module, for obtaining the original analysis result of blood constituent;
Determining module, for the rate of change according to electric current in preset time period, determines described current blood sample In hematocrite value, described electric current obtains by switching on power to the electrode being placed in described current blood sample ?;
Compensation module, for utilizing compensating value, makes corrections to described original analysis result, described correction Value generates according to described hematocrite value.
Alternatively, described determining module is used for the rate of change according to electric current in preset time period, determines institute The hematocrite value stated in current blood sample includes:
Described determining module is specifically for the first electrode for being placed in described current blood sample accesses default Voltage so that form concentration and between other electrodes of being placed in described current blood sample in described first electrode Difference, described concentration difference is used for producing electric current in described current blood sample;Detect in described preset time period, The variable quantity of the electric current in described blood sample;Calculate rate of change in described preset time period for the described variable quantity; According to the Changing Pattern of hematocrit curve, determine described rate of change corresponding hematocrit curve; According to described hematocrit curve, determine the hematocrite value in described current blood sample.
Alternatively, the quantity at least one of described other electrode.
Alternatively, described determining module is used for electricity in described preset time period, in described blood sample for the detection The variable quantity of stream includes:
Described determining module is specifically for electric current in described preset time period, in described blood sample for the detection Variable quantity, described preset time period includes: from default to first to the moment of described electrode input voltage Between moment;Or, from the second predetermined time to the 3rd predetermined time.
Alternatively, described electrode includes:
Carbon-containing electrode, conductor electrode, semi-conducting electrode or insulator electrode.
Blood component analyzing method described herein and device, using to being placed in described current blood sample Electrode switch on power and obtain in preset time period electric current variable quantity, determine in current blood sample Hematocrite value, and generate compensating value using hematocrite value, recycle compensating value to current blood sample The original analysis result of composition is maked corrections, thus it is possible to reduce hematocrite value to treat analysis ingredient Analysis result interference, thus improving the precision of analysis result, and because method described in the present embodiment And device, can get hemocyte ratio by measuring the rate of change of electric current in current blood sample in preset time period Capacitance, so, compare compared to the existing mode reducing the interference to analysis result for the hematocrite value, It is easily achieved, therefore, it is possible to reduce the complexity of blood component analyzing process.
Brief description
In order to be illustrated more clearly that the embodiment of the present application or technical scheme of the prior art, below will be to reality The accompanying drawing applying required use in example or description of the prior art be briefly described it should be apparent that, below Accompanying drawing in description is only some embodiments of the present application, for those of ordinary skill in the art, On the premise of not paying creative work, can also obtain other accompanying drawings according to these accompanying drawings.
Fig. 1 is a kind of flow chart of blood component analyzing method disclosed in the embodiment of the present application;
Fig. 2 is the disclosed stream determining the method for hematocrite value in current blood sample of the embodiment of the present application Cheng Tu;
Fig. 3 is the principle schematic producing electrochemical reaction in blood;
Fig. 4 is the when m- curent change schematic diagram of different hematocrit curves;
Fig. 5 is a kind of structural representation of blood component analyzing device disclosed in the embodiment of the present application.
Specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present application, the technical scheme in the embodiment of the present application is carried out Clearly and completely describe it is clear that described embodiment is only some embodiments of the present application, and It is not all, of embodiment.Based on the embodiment in the application, those of ordinary skill in the art are not doing The every other embodiment being obtained under the premise of going out creative work, broadly falls into the scope of the application protection.
A kind of blood component analyzing method disclosed in the embodiment of the present application, as shown in figure 1, include following walking Rapid:
S101: obtain the original analysis result of blood constituent;
S102: according to the rate of change of electric current in preset time period, determine that the blood in described current blood sample is thin Born of the same parents' bulking value, described electric current is by acquisition that the electrode being placed in described current blood sample is switched on power;
S103: generate compensating value according to described hematocrite value;
S104: using described compensating value, described original analysis result is maked corrections, described correction result Assay value for described current blood sample composition.
From above-mentioned steps as can be seen that in order to improve precision of analysis, in the present embodiment, with according to Generate compensating value (for example compensating value can be directly using hematocrite value) according to hematocrite value, right Original analysis result is maked corrections, and because hematocrite value is obtained by way of electrifying electrodes, institute With, it is easy to accomplish, thus simplifying the process of blood component analyzing.
Specifically, in the present embodiment, as shown in Fig. 2 determining the hematocrite value in current blood sample The process of implementing comprises the following steps:
S201: place electrode in current blood sample;
Specifically, the electrode of placement can include first electrode and other electrode, wherein, other electrodes Quantity can be one or more.
S202: access predeterminated voltage for the first electrode that is placed in current blood sample so that in first electrode Form concentration difference and between other electrodes, concentration difference is used for producing electric current in current blood sample;
Specifically, as shown in figure 3, to first electrode connect voltage in the case of, first electrode conduct Reacting substance in reaction pole, with blood sample reacts, around reaction pole, the solubility of reacting substance by Gradually it is reduced to 0, and the solubility reacting the side-product of generation is gradually increased.In other surrounding them, do not occur Reaction, so, compared with reaction pole, the concentration of the reacting substance in the solution of other surrounding them is high, And the concentration of side-product is low, therefore, reacting substance spreads to reaction pole from other surrounding them, and by-product Product spread to other surrounding them from reaction pole, thus producing electric current in blood sample.
Electrode in the present embodiment, can be blood component analyzing electrode, that is, the process shown in Fig. 2 with Blood component analyzing common electrode is it is also possible to be used alone electrode.Electrode can be carbon-containing electrode, conductor Electrode, semi-conducting electrode or insulator electrode etc..
S203: detect in preset time period, the variable quantity of the electric current in blood sample;
S204: calculate rate of change in preset time period for the variable quantity;
S205: according to the Changing Pattern of hematocrit curve, determine the corresponding hematocrit of rate of change Curve;
S206: according to hematocrit curve, determine the hematocrite value in current blood sample.
As shown in figure 4, the different hematocrits of different hematocrit curve correspondences, different blood The rate of change in preset time period of specific volume of cell curve is different.The present embodiment utilizes this principle, really Make the hematocrite value in current blood sample.
In Fig. 4, preset time period is with to the moment of electrode input voltage to the first predetermined time As a example time period, in addition, preset time period can also be when the second predetermined time to the 3rd is preset Time period between quarter, the second predetermined time and the 3rd predetermined time can set according to actual demand, this In do not limit.
Compared with traditional hematocrit determination mode, method described in the present embodiment, more simple.
With said method embodiment accordingly, the embodiment of the present application also discloses a kind of blood component analyzing Device, as shown in Figure 5, comprising:
Acquisition module 501, for obtaining the original analysis result of blood constituent;
Determining module 502, for the rate of change according to electric current in preset time period, determines described current blood Hematocrite value in sample, described electric current is switched on power by the electrode being placed in described current blood sample Obtain;
Compensation module 503, for utilizing compensating value, makes corrections to described original analysis result, described benefit On the occasion of according to the generation of described hematocrite value.
Specifically, in the present embodiment, the rate of change of determining module foundation electric current in preset time period, really The specific implementation of the hematocrite value in fixed described current blood sample can be: for being placed on described working as First electrode in front blood sample access predeterminated voltage so that described first electrode be placed on described current Form concentration difference, described concentration difference is used for producing electricity in described current blood sample between the other electrodes in blood sample Stream;Detect in described preset time period, the variable quantity of the electric current in described blood sample;Calculate described change Rate of change in described preset time period for the amount;According to the Changing Pattern of hematocrit curve, determine institute State rate of change corresponding hematocrit curve;According to described hematocrit curve, determine described current Hematocrite value in blood sample.
Wherein, the quantity of other electrodes at least one;Preset time period includes: from defeated to described electrode The moment entering voltage between the first predetermined time, or, from the second predetermined time to the 3rd predetermined time Between;Electrode can be carbon-containing electrode, conductor electrode, semi-conducting electrode or insulator electrode etc..
Device described in the present embodiment, can reduce the complexity of blood component analyzing.
If the function described in the embodiment of the present application method is realized and as solely using in the form of SFU software functional unit When vertical production marketing or use, can be stored in a computing device read/write memory medium.It is based on Such understanding, part or the portion of this technical scheme that the embodiment of the present application contributes to prior art Divide and can be embodied in the form of software product, this software product is stored in a storage medium, bag Include some instructions with so that computing device (can be personal computer, server, mobile computing Equipment or the network equipment etc.) execution each embodiment methods described of the application all or part of step. And aforesaid storage medium includes: u disk, portable hard drive, read only memory (rom, read-only Memory), random access memory (ram, random access memory), magnetic disc or light Disk etc. is various can be with the medium of store program codes.
In this specification, each embodiment is described by the way of going forward one by one, and each embodiment stresses The difference with other embodiments, between each embodiment same or similar partly mutually referring to.
Described above to the disclosed embodiments, makes professional and technical personnel in the field be capable of or uses The application.Multiple modifications to these embodiments will be aobvious and easy for those skilled in the art See, generic principles defined herein can in the case of without departing from spirit herein or scope, Realize in other embodiments.Therefore, the application is not intended to be limited to the embodiments shown herein, And it is to fit to the wide scope consistent with principles disclosed herein and features of novelty.

Claims (10)

1. a kind of blood component analyzing method is it is characterised in that include:
Obtain the original analysis result of blood constituent;
According to the rate of change of electric current in preset time period, determine the hematocrit in described current blood sample Value, described electric current is by acquisition that the electrode being placed in described current blood sample is switched on power;
Using described compensating value, described original analysis result is maked corrections, described compensating value is according to described Hematocrite value generates.
2. method according to claim 1 is it is characterised in that described foundation is in preset time period The variable quantity of electric current, determines that the hematocrite value in described current blood sample includes:
Access predeterminated voltage for the first electrode that is placed in described current blood sample so that in the described first electricity Form concentration difference, described concentration difference is used in institute between pole and other electrodes of being placed in described current blood sample State generation electric current in current blood sample;
Detect in described preset time period, the variable quantity of the electric current in described blood sample;
Calculate rate of change in described preset time period for the described variable quantity;
According to the Changing Pattern of hematocrit curve, determine that the corresponding hematocrit of described rate of change is bent Line;
According to described hematocrit curve, determine the hematocrite value in described current blood sample.
3. method according to claim 2 it is characterised in that described other electrode quantity at least For one.
4. method according to claim 1 and 2 is it is characterised in that described preset time period includes:
From to the moment of described electrode input voltage to the first predetermined time;
Or, from the second predetermined time to the 3rd predetermined time.
5. method according to claim 1 is it is characterised in that described electrode includes:
Carbon-containing electrode, conductor electrode, semi-conducting electrode or insulator electrode.
6. a kind of blood component analyzing device is it is characterised in that include:
Acquisition module, for obtaining the original analysis result of blood constituent;
Determining module, for the rate of change according to electric current in preset time period, determines described current blood sample In hematocrite value, described electric current obtains by switching on power to the electrode being placed in described current blood sample ?;
Compensation module, for utilizing compensating value, makes corrections to described original analysis result, described correction Value generates according to described hematocrite value.
7. device according to claim 6 is it is characterised in that described determining module exists for foundation The rate of change of electric current in preset time period, determines that the hematocrite value in described current blood sample includes:
Described determining module is specifically for the first electrode for being placed in described current blood sample accesses default Voltage so that form concentration and between other electrodes of being placed in described current blood sample in described first electrode Difference, described concentration difference is used for producing electric current in described current blood sample;Detect in described preset time period, The variable quantity of the electric current in described blood sample;Calculate rate of change in described preset time period for the described variable quantity; According to the Changing Pattern of hematocrit curve, determine described rate of change corresponding hematocrit curve; According to described hematocrit curve, determine the hematocrite value in described current blood sample.
8. device according to claim 7 it is characterised in that described other electrode quantity at least For one.
9. the device according to claim 7 or 8 is it is characterised in that described determining module is used for examining Survey in described preset time period, the variable quantity of the electric current in described blood sample includes:
Described determining module is specifically for electric current in described preset time period, in described blood sample for the detection Variable quantity, described preset time period includes: from default to first to the moment of described electrode input voltage Between moment;Or, from the second predetermined time to the 3rd predetermined time.
10. device according to claim 7 is it is characterised in that described electrode includes:
Carbon-containing electrode, conductor electrode, semi-conducting electrode or insulator electrode.
CN201510429981.6A 2015-07-21 2015-07-21 Blood component analysis method and blood component analysis apparatus Pending CN106370715A (en)

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