CN106237858A - A kind of high flux hemodialysis device - Google Patents
A kind of high flux hemodialysis device Download PDFInfo
- Publication number
- CN106237858A CN106237858A CN201610642597.9A CN201610642597A CN106237858A CN 106237858 A CN106237858 A CN 106237858A CN 201610642597 A CN201610642597 A CN 201610642597A CN 106237858 A CN106237858 A CN 106237858A
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- Prior art keywords
- dialysis
- dialysis tubing
- high flux
- liquid container
- hemodialysis device
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/28—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/243—Dialysis
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- Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The present invention relates to a kind of high flux hemodialysis device, including outer liquid container and inner support frame, described outer liquid container is built with dialysis solution, and described inner support frame is arranged on the inside of described outer liquid container；Described inner support frame includes dialyse tube sheet, Dialysis tubing and fixed plate, and described dialysis tube sheet and fixed plate are removably connected by connecting rod；Offering liquid filling hole on described dialysis tube sheet, described liquid filling hole extends outward liquid feeding mouth, and described fixed plate offers groove；One end of described Dialysis tubing is set on described liquid feeding mouth, and the other end of described Dialysis tubing is closed and be arranged in described groove, and the matching form of the shape of the other end of described Dialysis tubing and described groove closes.The invention provides a kind of high flux hemodialysis device, Dialysis tubing is put in outer liquid container, the dialyse tube wall area more than 90% and the contact of dialysis solution, compare existing dialysis machine, drastically increase efficiency and the flux of dialysis, decrease experiment operator labor intensity.
Description
Technical field
The invention belongs to biotechnological device field, be specifically related to a kind of high flux hemodialysis device.
Background technology
In the prior art, typically the biological macromolecule solns of constant level is dialysed with bag filter, changes liquid and concentration,
Bigger molecule can be restricted in bag by bag filter, allows less molecule pass freely through；Bag filter is largely used to biology, change
Etc. field.
There is following defect in existing bag filter: 1, a bag filter can only be dialysed a sample (content)；2, dialysis
Bag mostly needs loaded down with trivial details operating procedure before use, such as, cut out, soak and with clip sealing etc.；3, dialysis time is longer:
Some bag filter existing is little with dialysis solution contact area, and dialysis speed is slow；4, the sample size of dialysis is little: presently, there are some high
The bag filter of flux, but the sample size being suitable for is the least.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides a kind of high flux hemodialysis device, described height
Flux dialysis apparatus uses inner support frame to fix Dialysis tubing, and is fully immersed in dialysis solution by Dialysis tubing, greatly increases
Dialysis area, improves the flux of dialysis.
The technical solution adopted in the present invention is: a kind of high flux hemodialysis device, including outer liquid container and inner support frame, institute
Stating outer liquid container built with dialysis solution, described inner support frame is arranged on the inside of described outer liquid container；
Described inner support frame includes dialysing tube sheet, Dialysis tubing and fixed plate, described dialysis tube sheet and fixed plate by connecting
Bar removably connects；Offering liquid filling hole on described dialysis tube sheet, described liquid filling hole extends outward liquid feeding mouth, described fixed plate
On offer groove；One end of described Dialysis tubing is set on described liquid feeding mouth, and the other end of described Dialysis tubing is closed and arranged
In described groove, the matching form of the shape of the other end of described Dialysis tubing and described groove closes.
In use, by liquid filling hole and liquid feeding mouth, the sample needing dialysis is proceeded in Dialysis tubing, and Dialysis tubing is put
Enter in outer liquid container, the dialyse tube wall area more than 90% and the contact of dialysis solution, compare existing dialysis machine, greatly carry
The efficiency of high dialysis and flux, decrease experiment operator labor intensity.
Described Dialysis tubing uses dialyzer to make, and dialyzer is the most soft, easily deforms in dialysis solution, the present invention
Use dialysis tube sheet and fixed plate to fix the two ends of Dialysis tubing respectively, play fixing Dialysis tubing and by work fully deployed for Dialysis tubing
With；The most described dialysis tube sheet and fixed plate are removably connected by connecting rod, facilitate experiment operator to install fixing dialysis
Pipe.
Described Dialysis tubing uses dialyzer to make, and the enclosure method of the other end of described Dialysis tubing is: described Dialysis tubing
The other end uses glue encapsulating mouth.Glue encapsulating mouth can be processed in advance, simplifies the operating process of experiment operator.
As another kind of enclosure method, the other end of described Dialysis tubing uses adhesive tape to fix after folding, by described after fixing
The other end of Dialysis tubing puts into described groove.Said method has simple to operation, the advantage of good sealing effect.
Described connecting rod is expansion link: described connecting rod includes upper connecting rod and lower connecting rod, and described upper connecting rod is sheathed
On described lower connecting rod.Use expansion link, conveniently dismantle and regulate the distance between described dialysis tube sheet and fixed plate, with suitable
Answer the Dialysis tubing of different specification size.
For ensureing that described Dialysis tubing can be vertically placed in described outer liquid container, preferred technical scheme is, described interior
Support also includes that floating body, described floating body are arranged on described dialysis tube sheet, and the density of described floating body is less than dialysis solution
Density.Described floating body ensures that described liquid filling hole floats on the liquid level of dialysis solution simultaneously, it is to avoid sample is dialyzed liquid and pollutes.
According to one embodiment of present invention, described floating body uses foam plastics to make；Described liquid filling hole, liquid feeding mouth and
The number of Dialysis tubing is eight；Be covered with townhouse lid on described liquid filling hole, described floating body be embedded described liquid feeding mouth it
Between.In the lab, eight company lid and eight platoon pipes etc. are conventional equipment, described liquid filling hole, liquid feeding mouth and the number of Dialysis tubing
Mesh is eight, convenient with other equipment with the use of.Described townhouse lid is prevented from dialysis solution and enters in Dialysis tubing, it is to avoid
Sample is dialyzed liquid and pollutes.
Described outer liquid container is cuboid, and the one side of described outer liquid container is provided with the fastener of protrusion, and described outer liquid holds
The locating slot that the position that side is corresponding with described fastener is provided with indent of device, the shape phase of described fastener and locating slot
Coordinate.Described fastener and locating slot are arranged at the upper surface of described outer liquid container.
By fastener and locating slot with the use of, multiple outer liquid containers can repeat grafting arrangement, and then outside composition
Liquid container array, to adapt to the needs of different scales dialysis operation.
In described Dialysis tubing, the volume ratio of sample and described dialysis solution is 1:8-12；The volume of described outer liquid container is 16-
80ml.The described dialysis operation being sized to corresponding different sample size, such as 8 1ml, 8 0.5ml's and 8 0.2ml is saturating
Analysis pipe.
The invention have the benefit that
1, the invention provides a kind of high flux hemodialysis device, put into by Dialysis tubing in outer liquid container, dialysis tube wall exceedes
The area of 90% and the contact of dialysis solution, compare existing dialysis machine, drastically increases efficiency and the flux of dialysis, reduces
Experiment operator labor intensity.
2, described high flux hemodialysis device, it is possible to according to different samples and dialysis operation, select to change different dialysis
Film, it is possible to realize the dialysis operation of the macromole such as protein, RNA, DNA, antibody and antigen, and E.Coli or other antibacterials,
Plant and animal cell-free protein is expressed.
3, described outer liquid container is provided with fastener and locating slot, by fastener and locating slot with the use of, multiple
Outer liquid container can repeat grafting arrangement, and then forms outer liquid container array, to adapt to the needs of different scales dialysis operation.
Accompanying drawing explanation
Fig. 1 is the structural representation of inner support frame in the present invention；
Fig. 2 is the structural representation of present invention China and foreign countries liquid container.
In figure: 1, outer liquid container；2, inner support frame；21, dialysis tube sheet；22, Dialysis tubing；23, fixed plate；24, connecting rod；
25, floating body；211, liquid filling hole；212, liquid feeding mouth；213, townhouse lid；231, groove；241, upper connecting rod；242, lower connection
Bar；11, fastener；12, locating slot.
Detailed description of the invention
As depicted in figs. 1 and 2, the invention provides a kind of high flux hemodialysis device, including outer liquid container 1 and inner support frame
2, described outer liquid container 1 is arranged on the inside of described outer liquid container 1 built with dialysis solution, described inner support frame 2；
Described inner support frame 2 includes dialyse tube sheet 21, Dialysis tubing 22 and fixed plate 23, described dialysis tube sheet 21 and fixed plate
23 are removably connected by connecting rod 24；Offering liquid filling hole 211 on described dialysis tube sheet 21, described liquid filling hole 211 is to extension
Stretch out liquid feeding mouth 212, described fixed plate 23 offers groove 231；One end of described Dialysis tubing 22 is set in described liquid feeding mouth
On 212, the other end of described Dialysis tubing 22 is closed and is arranged in described groove 231, the shape of the other end of described Dialysis tubing 22
Shape closes with the matching form of described groove 231.
Described Dialysis tubing 22 uses dialyzer to make, it is possible to according to different samples and dialysis operation, select to change difference
Dialyzer, dialyzer is the most soft, easily in dialysis solution deform, described high flux hemodialysis device use dialysis tube sheet
21 and fixed plate 23 fix the two ends of Dialysis tubing 22 respectively, play fixing Dialysis tubing 22 and by work fully deployed for Dialysis tubing 22
With；The most described dialysis tube sheet 21 and fixed plate 23 are removably connected by connecting rod 24, facilitate experiment operator to install solid
Determine Dialysis tubing 22.
Described connecting rod 24 is expansion link: described connecting rod 24 includes upper connecting rod 241 and lower connecting rod 242, described on
Connecting rod 241 is set on described lower connecting rod 242.Described inner support frame 2 also includes that floating body 25, described floating body 25 are arranged
On described dialysis tube sheet 21, the density of described floating body 25 is less than the density of dialysis solution.Described floating body 25 ensures institute simultaneously
State liquid filling hole 211 and float on the liquid level of dialysis solution, it is to avoid sample is dialyzed liquid and pollutes.
The number of described liquid filling hole 211, liquid feeding mouth 212 and Dialysis tubing 22 is eight；It is covered with on described liquid filling hole 211
Townhouse lid 213, described floating body 25 is embedded between described liquid feeding mouth 212.In the lab, eight connect lid and eight platoon pipes
Etc. being conventional equipment, the number of described liquid filling hole 211, liquid feeding mouth 212 and Dialysis tubing 22 is eight, convenient with other equipment
With the use of.Described townhouse lid 213 is prevented from dialysis solution and enters in Dialysis tubing 22, it is to avoid sample is dialyzed liquid and pollutes.
In use, by liquid filling hole 211 and liquid feeding mouth 212, the sample needing dialysis is proceeded in Dialysis tubing 22, and will
Dialysis tubing 22 is put in outer liquid container 1, Dialysis tubing 22 wall area more than 90% and the contact of dialysis solution, compares existing dialysis
Equipment, drastically increases efficiency and the flux of dialysis, decreases experiment operator labor intensity.
Described floating body 25 uses foam plastics to make；As a kind of sealing means, the other end of described Dialysis tubing 22 makes
Mouth is encapsulated with glue；Or, the other end of described Dialysis tubing 22 uses adhesive tape to fix after folding, by described Dialysis tubing 22 after fixing
The other end puts into described groove 231.
Seeing Fig. 2, described outer liquid container 1 is cuboid, and the one side of described outer liquid container 1 is provided with the fastener of protrusion
11, the locating slot 12 that the position that side is corresponding with described fastener 11 is provided with indent of described outer liquid container 1, described fastening
The matching form of body 11 and locating slot 12 closes.By fastener 11 and locating slot 12 with the use of, multiple outer liquid containers 1 can
Repeat grafting arrangement, and then form outer liquid container 1 array, to adapt to the needs of different scales dialysis operation.
In described Dialysis tubing 22, the volume ratio of sample and described dialysis solution is 1:8-12；The volume of described outer liquid container 1 is
16-80ml.The described dialysis operation being sized to corresponding different sample size, such as 8 1ml, 8 0.5ml and 8 0.2ml
Dialysis tubing 22.
It should be noted last that, above example is only in order to illustrate technical scheme and unrestricted, although ginseng
According to preferred embodiment, the present invention is described in detail, it should be understood that and the foregoing is only being embodied as of the present invention
Mode, the protection domain being not intended to limit the present invention, all within the spirit and principles in the present invention, that is done any repaiies
Change, equivalent, improvement etc., should be included within the scope of the present invention.
Claims (10)
1. a high flux hemodialysis device, it is characterised in that include outer liquid container (1) and inner support frame (2), described outer liquid container
(1) built with dialysis solution, described inner support frame (2) is arranged on the inside of described outer liquid container (1)；
Described inner support frame (2) includes dialyse tube sheet (21), Dialysis tubing (22) and fixed plate (23), described dialysis tube sheet (21) and
Fixed plate (23) is removably connected by connecting rod (24)；Offer liquid filling hole (211) on described dialysis tube sheet (21), described in add
Fluid apertures (211) extends outward liquid feeding mouth (212), and described fixed plate (23) offers groove (231)；Described Dialysis tubing (22)
One end be set on described liquid feeding mouth (212), described groove (231) is closed and be arranged on to the other end of described Dialysis tubing (22)
In.
High flux hemodialysis device the most according to claim 1, it is characterised in that described Dialysis tubing (22) uses dialyzer system
Become.
High flux hemodialysis device the most according to claim 1, it is characterised in that the envelope of the other end of described Dialysis tubing (22)
The method of closing is: the other end of described Dialysis tubing (22) uses glue encapsulating mouth.
High flux hemodialysis device the most according to claim 1, it is characterised in that the envelope of the other end of described Dialysis tubing (22)
The method of closing is: the other end of described Dialysis tubing (22) uses adhesive tape to fix after folding, fixing after another by described Dialysis tubing (22)
Described groove (231) is put in one end.
High flux hemodialysis device the most according to claim 1, it is characterised in that described connecting rod (24) is expansion link: institute
Stating connecting rod (24) and include upper connecting rod (241) and lower connecting rod (242), described upper connecting rod (241) is set in described lower company
On extension bar (242).
High flux hemodialysis device the most according to claim 1, it is characterised in that described inner support frame (2) also includes floating
Body (25), described floating body (25) is arranged on described dialysis tube sheet (21), and the density of described floating body (25) is less than dialysis solution
Density.
High flux hemodialysis device the most according to claim 6, it is characterised in that described floating body (25) uses foam plastics
Make.
High flux hemodialysis device the most according to claim 6, it is characterised in that described liquid filling hole (211), liquid feeding mouth
And the number of Dialysis tubing (22) is eight (212)；Townhouse lid (213) it is covered with on described liquid filling hole (211), described floating
Body (25) is embedded between described liquid feeding mouth (212).
9. according to the arbitrary described high flux hemodialysis device of claim 1-8, it is characterised in that described outer liquid container (1) is for long
Cube, the one side of described outer liquid container (1) is provided with the fastener (11) of protrusion, described outer liquid container (1) to side and institute
State the corresponding position of fastener (11) and be provided with the locating slot (12) of indent, described fastener (11) and the shape of locating slot (12)
Match.
High flux hemodialysis device the most according to claim 9, it is characterised in that described Dialysis tubing (22) interior sample and institute
The volume ratio stating dialysis solution is 1:8-12；The volume of described outer liquid container (1) is 16-80ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610642597.9A CN106237858B (en) | 2016-08-04 | 2016-08-04 | A kind of high flux hemodialysis device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610642597.9A CN106237858B (en) | 2016-08-04 | 2016-08-04 | A kind of high flux hemodialysis device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106237858A true CN106237858A (en) | 2016-12-21 |
| CN106237858B CN106237858B (en) | 2019-02-15 |
Family
ID=58078349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610642597.9A Active CN106237858B (en) | 2016-08-04 | 2016-08-04 | A kind of high flux hemodialysis device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106237858B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245721A (en) * | 2018-01-17 | 2018-07-06 | 杭州谨澳生物科技有限公司 | A kind of dialysis apparatus, dialysis apparatus group and dialysis system |
| CN108753594A (en) * | 2018-08-15 | 2018-11-06 | 湖北省农业科学院粮食作物研究所 | A kind of high throughput biological sample grinding device and its grinding method |
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| EP1088589A2 (en) * | 1999-09-30 | 2001-04-04 | Pfizer Products Inc. | Micro-equilibrium dialysis vertically loaded apparatus |
| CN102596373A (en) * | 2009-10-29 | 2012-07-18 | 查尔斯斯塔克德雷珀实验室公司 | Microfluidic device for blood dialysis |
| CN202569964U (en) * | 2012-03-23 | 2012-12-05 | 上海蓝怡科技有限公司 | Dialysis device |
| CN102816202A (en) * | 2012-08-14 | 2012-12-12 | 上海交通大学 | Monolithic column electroelution apparatus and method thereof |
| CN203043852U (en) * | 2012-12-29 | 2013-07-10 | 山东天维膜技术有限公司 | Flat plate type dialyzer |
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2016
- 2016-08-04 CN CN201610642597.9A patent/CN106237858B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1088589A2 (en) * | 1999-09-30 | 2001-04-04 | Pfizer Products Inc. | Micro-equilibrium dialysis vertically loaded apparatus |
| CN102596373A (en) * | 2009-10-29 | 2012-07-18 | 查尔斯斯塔克德雷珀实验室公司 | Microfluidic device for blood dialysis |
| CN202569964U (en) * | 2012-03-23 | 2012-12-05 | 上海蓝怡科技有限公司 | Dialysis device |
| CN102816202A (en) * | 2012-08-14 | 2012-12-12 | 上海交通大学 | Monolithic column electroelution apparatus and method thereof |
| CN203043852U (en) * | 2012-12-29 | 2013-07-10 | 山东天维膜技术有限公司 | Flat plate type dialyzer |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245721A (en) * | 2018-01-17 | 2018-07-06 | 杭州谨澳生物科技有限公司 | A kind of dialysis apparatus, dialysis apparatus group and dialysis system |
| CN108245721B (en) * | 2018-01-17 | 2021-09-10 | 杭州迅耀生物科技有限公司 | Dialysis device, dialysis device set and dialysis system |
| CN108753594A (en) * | 2018-08-15 | 2018-11-06 | 湖北省农业科学院粮食作物研究所 | A kind of high throughput biological sample grinding device and its grinding method |
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| Publication number | Publication date |
|---|---|
| CN106237858B (en) | 2019-02-15 |
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