CN106236085B - For detecting the generating device and detection method of NEG cerebration instrument synchronism - Google Patents
For detecting the generating device and detection method of NEG cerebration instrument synchronism Download PDFInfo
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- 238000001514 detection method Methods 0.000 title claims abstract description 24
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- 239000004973 liquid crystal related substance Substances 0.000 claims abstract description 19
- 230000005611 electricity Effects 0.000 claims abstract description 17
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 claims abstract description 16
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- 239000000523 sample Substances 0.000 claims description 18
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- 238000009499 grossing Methods 0.000 claims description 7
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- 238000005259 measurement Methods 0.000 claims description 6
- 230000006870 function Effects 0.000 description 24
- 238000000034 method Methods 0.000 description 5
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- 230000003925 brain function Effects 0.000 description 1
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- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
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Abstract
For detecting the generating device and detection method of NEG cerebration instrument synchronism, including the fNIRS signal generation module being connected with NEG cerebration instrument and the electrode tip holder being connected with NEG cerebration instrument, and the oscillograph being connected with the signal output end of NEG cerebration instrument, the 24V power supply is separately connected fNIRS signal generation module and electrode tip holder by switch, for provide power supply to fNIRS signal generation module and electrode tip holder.The generating device for detecting NEG cerebration instrument synchronism is connected first；The signal received from apparatus of the present invention is acquired, by controlling the switch on and off of power supply in apparatus of the present invention, changes the light transmission capacity of liquid crystal darkening piece, and when closing the switch, provides synchronous electric signal to electrode tip holder；The time difference of shown function near-infrared step signal and brain electricity step signal on measuring oscilloscope, to assess the photoelectric synchronous performance of NEG cerebration instrument.Operation of the present invention is simple, can accurately provide Microsecond grade synchronous photosignal.
Description
Technical field
The present invention relates to a kind of generating devices.More particularly to a kind of for detecting the generation of NEG cerebration instrument synchronism
Device and detection method.
Background technique
Brain function activity detector is intended to effective combination by function near-infrared spectrum technique and brain wave acquisition technology,
Near infrared spectrometer, three function integration skill of electroencephalograph and near infrared spectrum and brain electro' asion instrument are realized on same instrument
Art, to realize the multiple functions such as brain area nerve electrical activity is synchronous with blood sample information provision or acquires respectively.
Although having there is many equipment or system for being used to detect brain activity in the market, they are typically based on list
The measuring technique of mode, such as: EEG (electroencephalogram) only acquires the electrical activity of brain neuron, fNIRS (functional near infrared spectrum
Technology) only acquire active region blood oxygen metabolism variation, on the one hand, these manufacturers are only absorbed in production single mode
Measuring system is not proficient in the measurement of another mode；On the other hand, the Collect jointly system of bimodal, it is hard due to existing
Part integration cost and data synchronous fusion are related to difficult point, so far, both at home and abroad still without photoelectric synchronous detection device or
System does not also retrieve related patents.
With some about NEG systematic research and the appearance of MNEG-5000 instrument recently, in order to realize its bimodal
The critical function of synchronous acquisition seems increasingly important for the evaluation of the net synchronization capability of its blood oxygen signal and EEG signals, therefore,
One simple synchronizable optical electrical signal generating circuit of design has certain necessity.
Summary of the invention
The technical problem to be solved by the invention is to provide one kind can be implemented as detection NEG system photoelectric synchronous performance
Generating device and the detection side for being used to detect NEG cerebration instrument synchronism of the synchronous fNIRS of Microsecond grade and EEG signal are provided
Method.
The technical scheme adopted by the invention is that: it is a kind of for detecting the generating device of NEG cerebration instrument synchronism, including
24V power supply is additionally provided with the fNIRS signal being connected with NEG cerebration instrument for detecting NEG cerebration instrument function near infrared signal
Generation module and the electrode tip holder for detecting NEG cerebration instrument EEG signals that is connected with NEG cerebration instrument, and it is living with NEG brain
The signal output end of dynamic instrument is connected the oscillograph of function near infrared signal and EEG signals for showing NEG cerebration instrument, institute
The 24V power supply stated is separately connected fNIRS signal generation module and electrode tip holder by switch, for generate mould to fNIRS signal
Block and electrode tip holder provide power supply.
The fNIRS signal generation module includes shielding box, be arranged in shielding box in same optical path be located at into
Penetrate the optical filter of light side and the liquid crystal darkening piece positioned at optical filter emergent light side, wherein shielding box incident light side
The light source probe of the NEG cerebration instrument is set on face by light inlet, by going out light on the shielding box emergent light one side
The detection probe of the NEG cerebration instrument mouthful is set, the power input of the liquid crystal darkening piece by with first resistor and
The output end of connection connection 24V power supply.
The electrode tip holder is the power supply electrode seat with 8 channels, and the power input of the electrode tip holder is separately connected second
One end of resistance and 3rd resistor, the other end of the second resistance and one end of first resistor connect the defeated of 24V power supply jointly
Outlet, the other end of the 3rd resistor and the other end of first resistor connect the ground terminal of 24V power supply jointly, the electrode tip holder
The electrode for encephalograms of output connection NEG cerebration instrument.
It is a kind of for detecting the detection method of the generating device of NEG cerebration instrument synchronism, include the following steps:
1) generating device for detecting NEG cerebration instrument synchronism is connected, that is, the function of NEG cerebration instrument is closely red
The light source probe and detection probe of outer detection module are respectively connected in the generating device for detecting NEG cerebration instrument synchronism
On the shielding box corresponding position of fNIRS signal generation module, the electrode for encephalograms line of NEG cerebration instrument is connected to and is used to detect
On the electrode tip holder of the generating device of NEG cerebration instrument synchronism, and by the function near-infrared output end signal of NEG cerebration instrument and
Brain electricity output end signal is connected respectively on two channels of oscillograph；
2) NEG cerebration instrument is opened, the letter received from the generating device for detecting NEG cerebration instrument synchronism is acquired
Number, by controlling the switch on and off of power supply in the generating device for detecting NEG cerebration instrument synchronism, change liquid crystal darkening piece
Light transmission capacity give electrode tip holder to provide synchronous electric signal and when closing the switch；
3) by the respective keys on operation oscillograph, on measuring oscilloscope shown function near-infrared step signal and
The time difference of brain electricity step signal, to assess the photoelectric synchronous performance of NEG cerebration instrument.
Step 2) further include: adjust the translucent effect of liquid crystal darkening piece front filter and the photosensitive ginseng of NEG cerebration instrument
Number, so that the light intensity signal that NEG cerebration instrument detects when 24V power switch disconnects is in the specified range of NEG cerebration instrument
Middle part.
NEG cerebration instrument starts after acquiring photosignal in step 2), and the oscillograph being connected with NEG cerebration instrument starts to draw
Then real-time function near infrared signal curve and EEG signals curve processed are closed the switch of 24V power supply, break again after 5 seconds
It opens, to make that oscilloscope display goes out function near-infrared live signal and a Spline smoothing all occurs in brain electricity live signal curve.
By there is step change on measurement function near infrared signal and EEG signals this two live signals curves in step 3)
The time difference of change assesses the net synchronization capability of NEG cerebration instrument, occurs when function near-infrared step signal and brain electricity step signal
When time difference is less than 0.01s, it is believed that the photoelectric synchronous of NEG cerebration instrument reaches Microsecond grade, otherwise it is assumed that NEG cerebration instrument
Synchronism requirement in use cannot be reached.
The generating device and detection method for being used to detect NEG cerebration instrument synchronism of the invention, design is simple, is easy to real
Existing, device volume is smaller, easy to operate, easy to carry and use.It can accurately provide Microsecond grade synchronous photosignal, and equipment
Circuit parameter and photosignal output interface expansion it is stronger, have stronger suitability to the NEG equipment on current market
And compatibility.
Detailed description of the invention
Fig. 1 is the whole knot block diagram of generating device of the present invention for detecting NEG cerebration instrument synchronism；
Fig. 2 is the use state diagram of generating device of the present invention for detecting NEG cerebration instrument synchronism；
Fig. 3 is the electrical connection schematic diagram of generating device of the present invention for detecting NEG cerebration instrument synchronism.
In figure
1:24V power supply 2:fNIRS signal generation module
21: optical filter 22: liquid crystal darkening piece
23: shielding box 3: electrode tip holder
4:NEG cerebration instrument 41: light source probe
42: detection probe 43: electrode for encephalograms
5: oscillograph
Specific embodiment
Below with reference to embodiment and attached drawing to of the invention for detecting generating device and the inspection of NEG cerebration instrument synchronism
Survey method is described in detail.
Invention it is a kind of for detecting the generating device of NEG cerebration instrument synchronism, main body is a synchronous photosignal
Generating device is applied separately to photoelectric synchronous NEG brain for generating the light absorption step signal and step electric signal of stringent synchronization
In function near-infrared (fNIRS) module and brain electricity module of movable appearance, then the oscillography being connected by observation with cerebration detector
The signal graph that device obtains whether stringent synchronization, to detect the photoelectric synchronous of the cerebration detector.
As shown in Figure 1 and Figure 2, invention is a kind of for detecting the generating device of NEG cerebration instrument synchronism, including 24V electricity
The output end in source 1, the 24V power supply 1 is provided with switch K.It is additionally provided with to be connected with NEG cerebration instrument 4 and live for detecting NEG brain
It moves the fNIRS signal generation module 2 of 4 function near infrared signal of instrument and is connected with NEG cerebration instrument 4 for detecting NEG cerebration
The electrode tip holder 3 of 4 EEG signals of instrument, and be connected with the signal output end of NEG cerebration instrument 4 for showing NEG cerebration instrument 4
The oscillograph 5 of function near infrared signal and EEG signals, the 24V power supply 1 are separately connected the life of fNIRS signal by switch K
At module 2 and electrode tip holder 3, for provide power supply to fNIRS signal generation module 2 and electrode tip holder 3.
As shown in figure 3, the fNIRS signal generation module 2 includes shielding box 23, it is arranged same in shielding box 23
The liquid crystal darkening piece 22 positioned at the optical filter 21 of incident light side and positioned at 21 emergent light side of optical filter in optical path, wherein
The light source probe 41 of the NEG cerebration instrument 4, the shielding are set on the 23 incident light one side of shielding box by light inlet
The detection probe 42 of the NEG cerebration instrument 4, the liquid crystal darkening piece 22 are set on 23 emergent light one side of box by light-emitting window
Power input pass through the output end for being connected in parallel 24V power supply 1 with first resistor R1.
The electrode tip holder 3 is the power supply electrode seat with 8 channels, and the power input of the electrode tip holder 3 is separately connected the
One end of one resistance R2 and second resistance R3, the other end of the first resistor R2 and one end of protective resistance R1 connect jointly
The output end of 24V power supply 1, the other end of the second resistance R3 and the other end of protective resistance R1 connect 24V power supply 1 jointly
The voltage of 2.4mV is added in the both ends of the electrode tip holder 3 of output electric signal, the electricity to realize the partial pressure of 10000:1 by ground terminal
The electrode for encephalograms 43 of the output connection NEG cerebration instrument 4 of electrode seat 3.
It is of the invention a kind of for detecting the generating device of NEG cerebration instrument synchronism, it is powered using 24V DC power supply,
The current switching of liquid crystal darkening piece 22 is controlled by switch K, so that control is put in the liquid crystal darkening piece 22 between light source and probe
Absorptance, the shielding box of liquid crystal darkening piece 22, the maskable ambient after connection light source probe 41 and detection probe 42.By
2.4mV power voltage supply of the 24V power supply after first resistor R2 and second resistance R3 partial pressure is to electrode tip holder 3.
In the net synchronization capability of actual measurement NEG cerebration instrument 4, NEG cerebration instrument 4 is connected according to shown in Fig. 3 first
To of the invention for detecting the generating device of NEG cerebration instrument synchronism, the saturating of liquid crystal darkening piece front filter is then adjusted
The photosensitive parameter of light effect and equipment, so that electricity in the generating device for detecting NEG cerebration instrument synchronism of the invention
The light intensity signal that NEG cerebration instrument detects when source switch disconnects is in the middle part of the specified range of equipment.Then NEG cerebration instrument
Start to acquire photosignal, oscillograph starts to draw real-time light intensity signal curve and EEG signals curve, later closure signal
The switch of generator disconnects again after 5 seconds, and at this moment fNIRS and EEG live signal curve shown by oscillograph can all occur
One Spline smoothing can assess NEG system by there is the time difference of Spline smoothing on both measurements live signal curve
Net synchronization capability.
The detection method of generating device for detecting NEG cerebration instrument synchronism of the invention, includes the following steps:
1) generating device for detecting NEG cerebration instrument synchronism is connected, that is, the function of NEG cerebration instrument is closely red
The light source probe and detection probe of outer detection module are respectively connected in the generating device for detecting NEG cerebration instrument synchronism
On the shielding box corresponding position of fNIRS signal generation module, the electrode for encephalograms line of NEG cerebration instrument is connected to and is used to detect
On the electrode tip holder of the generating device of NEG cerebration instrument synchronism, and by the function near-infrared output end signal of NEG cerebration instrument and
Brain electricity output end signal is connected respectively on two channels of oscillograph, with two echo signal to be seen；
2) NEG cerebration instrument is opened, the sense of the translucent effect and NEG cerebration instrument of liquid crystal darkening piece front filter is adjusted
Optical parameter, so that the light intensity signal that NEG cerebration instrument detects when 24V power switch disconnects is in NEG cerebration instrument rated capacity
The middle part of journey.The signal received from the generating device for detecting NEG cerebration instrument synchronism is acquired, by controlling for examining
The switch on and off of power supply in the generating device of NEG cerebration instrument synchronism is surveyed, the light transmission capacity of liquid crystal darkening piece is changed, and is being switched
When closure, synchronous electric signal is provided to electrode tip holder；NEG cerebration instrument starts after acquiring photosignal, is connected with NEG cerebration instrument
Oscillograph start to draw real-time function near infrared signal curve and EEG signals curve, be then closed the switch of 24V power supply,
It is disconnected after 5 seconds again, to make that oscilloscope display goes out function near-infrared live signal and brain electricity live signal curve all occurs
One Spline smoothing.
3) by the respective keys on operation oscillograph, on measuring oscilloscope shown function near-infrared step signal and
The time difference of brain electricity step signal, to assess the photoelectric synchronous performance of NEG cerebration instrument.Since liquid crystal darkening piece is by power on/off
The response time of influence is delicate grade, it is believed that the step electric signal in function near-infrared step signal and electrode tip holder is Microsecond grade
Synchronous.
By there is the time of Spline smoothing on measurement function near infrared signal and EEG signals this two live signals curves
Difference assesses the net synchronization capability of NEG cerebration instrument, small when the time difference that function near-infrared step signal and brain electricity step signal occur
When 0.01s, it is believed that the photoelectric synchronous of NEG cerebration instrument reaches Microsecond grade, otherwise it is assumed that NEG cerebration instrument cannot reach
Synchronism requirement in use.
Claims (6)
1. a kind of for detecting the generating device of NEG cerebration instrument synchronism, including 24V power supply (1), which is characterized in that also set
It is equipped with to be connected with NEG cerebration instrument (4) and generates mould for detecting the fNIRS signal of NEG cerebration instrument (4) function near infrared signal
Block (2) and the electrode tip holder (3) being connected with NEG cerebration instrument (4) for detecting NEG cerebration instrument (4) EEG signals, Yi Jiyu
The signal output end of NEG cerebration instrument (4) is connected function near infrared signal and brain telecommunications for showing NEG cerebration instrument (4)
Number oscillograph (5), the 24V power supply (1) by switch (K) be separately connected fNIRS signal generation module (2) and electrode tip holder
(3), for provide power supply to fNIRS signal generation module (2) and electrode tip holder (3)；The fNIRS signal generation module
(2) include shielding box (23), the optical filter (21) positioned at incident light side in shielding box (23) in same optical path is set
With the liquid crystal darkening piece (22) for being located at optical filter (21) emergent light side, wherein on shielding box (23) the incident light one side
The light source probe (41) of the NEG cerebration instrument (4) is set by light inlet, is led on shielding box (23) the emergent light one side
The detection probe (42) that the NEG cerebration instrument (4) is arranged in light-emitting window is crossed, the power input of the liquid crystal darkening piece (22) is logical
Cross the output end for being connected in parallel 24V power supply (1) with first resistor (R1).
2. according to claim 1 for detecting the generating device of NEG cerebration instrument synchronism, which is characterized in that described
Electrode tip holder (3) be the power supply electrode seat with 8 channels, the power supply positive input and 3rd resistor (R3) of the electrode tip holder (3)
One end be all connected with the one end of second resistance (R2) far from 24V power supply (1) anode, the power cathode of the electrode tip holder (3) inputs
The other end of end and 3rd resistor (R3) are all connected with the ground terminal of 24V power supply (1), and the output connection NEG brain of the electrode tip holder (3) is living
The electrode for encephalograms (43) of dynamic instrument (4), the power output end of the 24V power supply (1) are parallel with first resistor (R1).
3. a kind of described in claim 1 for detecting the detection method of the generating device of NEG cerebration instrument synchronism, feature
It is, includes the following steps:
1) generating device for detecting NEG cerebration instrument synchronism is connected, that is, examine the function near-infrared of NEG cerebration instrument
The light source probe and detection probe for surveying module are respectively connected in the generating device for detecting NEG cerebration instrument synchronism
On the shielding box corresponding position of fNIRS signal generation module, the electrode for encephalograms line of NEG cerebration instrument is connected to and is used to detect
On the electrode tip holder of the generating device of NEG cerebration instrument synchronism, and by the function near-infrared output end signal of NEG cerebration instrument and
Brain electricity output end signal is connected respectively on two channels of oscillograph；
2) NEG cerebration instrument is opened, the signal received from the generating device for detecting NEG cerebration instrument synchronism is acquired,
By controlling the switch on and off of power supply in the generating device for detecting NEG cerebration instrument synchronism, change liquid crystal darkening piece
Light transmission capacity, and when closing the switch, synchronous electric signal is provided to electrode tip holder；
3) by the respective keys on operation oscillograph, shown function near-infrared step signal and brain electricity on measuring oscilloscope
The time difference of step signal, to assess the photoelectric synchronous performance of NEG cerebration instrument.
4. according to claim 3 for detecting the detection method of the generating device of NEG cerebration instrument synchronism, feature
It is, step 2) further include: the translucent effect of liquid crystal darkening piece front filter and the photosensitive parameter of NEG cerebration instrument are adjusted,
So that the light intensity signal that NEG cerebration instrument detects when 24V power switch disconnects is in the specified range of NEG cerebration instrument
Portion.
5. according to claim 3 for detecting the detection method of the generating device of NEG cerebration instrument synchronism, feature
It is, NEG cerebration instrument starts after acquiring photosignal in step 2), and the oscillograph being connected with NEG cerebration instrument starts to draw
Then real-time function near infrared signal curve and EEG signals curve are closed the switch of 24V power supply, disconnect again after 5 seconds,
To make, oscilloscope display goes out function near-infrared live signal and a Spline smoothing all occurs in brain electricity live signal curve.
6. according to claim 3 for detecting the detection method of the generating device of NEG cerebration instrument synchronism, feature
It is, by there is Spline smoothing on measurement function near infrared signal and EEG signals this two live signals curves in step 3)
Time difference assesses the net synchronization capability of NEG cerebration instrument, when the time that function near-infrared step signal and brain electricity step signal occur
When difference is less than 0.01s, it is believed that the photoelectric synchronous of NEG cerebration instrument reaches Microsecond grade, otherwise it is assumed that NEG cerebration instrument cannot
Reach synchronism requirement in use.
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| CN100546391C (en) * | 2007-03-09 | 2009-09-30 | 北京牡丹视源电子有限责任公司 | Digital TV video and audio synchronous method of measurement |
| JP2010000283A (en) * | 2008-06-23 | 2010-01-07 | Shimadzu Corp | Real-time simultaneous measuring system, real-time simultaneous measuring instrument, real-time simultaneous measuring method and program |
| CN101449968B (en) * | 2008-12-31 | 2011-05-25 | 华中科技大学 | Method and device for in-phase measurement of near infrared brain function detector |
| CN102445327B (en) * | 2011-09-22 | 2014-05-07 | 青岛海信电器股份有限公司 | Method and system for measuring synchronism of 3D (three-dimensional) eyeglasses |
| CN203688674U (en) * | 2014-01-02 | 2014-07-02 | 国家电网公司 | PMU detection device synchronism detector |
| US10595741B2 (en) * | 2014-08-06 | 2020-03-24 | Institute Of Automation Chinese Academy Of Sciences | Method and system for brain activity detection |
| CN104287726B (en) * | 2014-08-27 | 2016-08-24 | 中国科学院自动化研究所 | A kind of cerebration event synchronization record system and method |
| CN104207770B (en) * | 2014-08-27 | 2017-02-15 | 中国科学院自动化研究所 | Wearable photoelectric synchronous brain activity wireless monitoring equipment |
| CN204181624U (en) * | 2014-09-18 | 2015-03-04 | 中国科学院自动化研究所 | The helmet of photoelectric synchronous cerebral function imaging instrument and use thereof |
| WO2016041187A1 (en) * | 2014-09-19 | 2016-03-24 | 中国科学院自动化研究所 | Method for photoelectrically synchronizing data storage of brain activity recording |
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