CN106214130A - A kind of hand-held optical imaging and ultra sonic imaging multi-modal fusion imaging system and method - Google Patents
A kind of hand-held optical imaging and ultra sonic imaging multi-modal fusion imaging system and method Download PDFInfo
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- CN106214130A CN106214130A CN201610797078.XA CN201610797078A CN106214130A CN 106214130 A CN106214130 A CN 106214130A CN 201610797078 A CN201610797078 A CN 201610797078A CN 106214130 A CN106214130 A CN 106214130A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4416—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B8/46—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient
- A61B8/461—Displaying means of special interest
- A61B8/466—Displaying means of special interest adapted to display 3D data
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- A—HUMAN NECESSITIES
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- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
- A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
- A61B8/5261—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image combining images from different diagnostic modalities, e.g. ultrasound and X-ray
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- G06T2207/10064—Fluorescence image
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Abstract
The invention discloses a kind of hand-held optical imaging and ultra sonic imaging multi-modal fusion imaging system and method, this system includes: hand-held optical image-forming module, ultrasound imaging module, mechanical close module, data processing module, wherein: mechanical close module is used for encapsulating whole imaging system and data processing module；Hand-held optical image-forming module is for carrying out optical imagery to biological tissue to be measured, and ultrasound imaging module for carrying out 3 D ultra sonic imaging to biological tissue to be measured；Hand-held optical image-forming module and ultrasound imaging module share a high-performance data processing module, are used for controlling to coordinate imaging device, signals collecting, image reconstruction and registration and merge；The present invention can reflect more fully structure and physiological function information in conjunction with Optical imaging modalities and the advantage of 3 D ultrasound imaging modality.
Description
Technical field
The present invention relates to multi-modal biomedical imaging technical field, particularly relate to a kind of ultrasonic hand-held imaging and optics
Imaging multi-modal fusion imaging system and method.
Background technology
Having benefited from the continuous progress of optical molecular probe and imaging means, optical molecular image technology was in more than ten years in past
Obtain development at full speed, and because of its high sensitivity, high specific, receive more to come without ionizing radiation, the feature such as with low cost
The most concerns.Optical molecular probe technique makes the differentiation normal structure of high specific and tissue of interest (such as tumor, blood vessel
Deng) be possibly realized.The most highly sensitive detection molecules probe distribution situation in biology and then reaction organism physiology, disease
Reason information is a major issue of iconography research.Owing to biological tissue has the strongest absorption and scattering process to photon,
The degree of depth causing optical imagery is limited, and the spatial resolution ratio that optical 3-dimensional is rebuild is relatively low.Improve optical imagery the most further
Imaging depth and the precision of three-dimensional reconstruction, be optical molecular image problem demanding prompt solution.To this end, contemplate imaging depth ratio
Relatively deep, ripe image mode-ultra sonic imaging.Ultrasonic in human body propagate time, at the interface of two kinds of different tissues
Place produces reflection and refraction, propagates, owing to the uniformity of not allowing of tissue scatters in same tissue.Ultrasonic pass through
Different Organs and tissue produce reflection and Scattering Rules, and instrument utilizes these reflection and scattered signals, demonstrates the interface of internal organs
With the fine result of organization internal, as diagnosis foundation.Light decay in biological tissue than ultrasound wave in-house
Decaying serious many, therefore ultra sonic imaging can be with the deeper degree of depth of imaging.
Imaging-PAM occupies an important position in the development of molecular image.Fluorescent molecules imaging
(fluorescence molecular imaging, FMT), it is possible to achieve the three-dimensional reconstruction of fluorescence signal.Due to fluorescent photon
High scattering properties in vivo, the spatial resolution ratio causing fluorescence imaging is relatively low, and three-dimensional reconstruction also has the strongest disease
State property.To this end, a lot of research worker introduce other image modes to make up the deficiency of Imaging-PAM.By X-ray CT imaging with
FMT imaging technique merges, it is possible to use the high-resolution organism anatomical structure that CT imaging technique provides carries as prior information
The three-dimensional reconstruction quality of high fluorescence signal.Although but CT imaging can provide high-resolution structural information, during CT imaging not
Evitable there is ionizing radiation, and the resolution of soft tissue is compared relatively low by CT imaging.Except CT imaging, magnetic resonance becomes
Anatomical information is provided into optical 3-dimensional imaging as (Magnetic Resonance Imaging, MRI) can also be used for.MRI
Imaging is possible not only to provide the soft tissue resolution of high-contrast, may be provided for the functional metabolism information of organism simultaneously.But
Being optical image technology and MRI imaging to be combined, need to produce the magnetic field of superelevation field intensity, this causes the volume ratio of imaging device
Relatively big, equipment cost is higher, thus limits the development of this multi-modal fusion mode.
Different from fluorescence imaging, in ultra sonic imaging, imaging system detection is reflection echo and scatter echo.Human body is tied
Structure is a complicated medium for ultrasonic, and various organs and tissue include that pathologic group is woven with its specific acoustic impedance and decay
Characteristic, thus constitute the difference on acoustic impedance and the difference in decay, this is also the basis of ultrasonoscopy.Ripple due to ultrasound wave
Long smaller, therefore can obtain the mechanics of biological tissue information of high spatial resolution.Ultra sonic imaging is combined with fluorescence imaging,
Ultra sonic imaging can be utilized to provide the mechanics of biological tissue physiologic information of profound level for fluorescent three-dimensional imaging, thus overcome light to study
As the shortcoming that the degree of depth is inadequate.
Summary of the invention
(1) to solve the technical problem that
The purpose of the present invention is to propose to a kind of hand-held optical imaging and ultra sonic imaging multi-modal fusion imaging system and side
Method, in conjunction with Optical imaging modalities and the advantage of 3-D ultrasound imaging modality, reflects more fully structure and physiological function information.
(2) technical scheme
For reaching above-mentioned purpose, the technical scheme is that
A kind of hand-held optical imaging and ultra sonic imaging multi-modal fusion imaging system, including optical imagery module, ultrasonic
Image-forming module and data processing module, described optical imagery module is for carrying out optical imagery to biological tissue to be measured；Ultrasonic one-tenth
As module is for carrying out ultra sonic imaging to biological tissue to be measured；Data processing module and described optical imagery module and ultra sonic imaging
Module connects respectively, processes with the data message sending described optical imagery module and ultrasound imaging module.
In such scheme, described optical imagery module includes continuous wave laser, coupling device and hand-held optical probe.
Described continuous wave laser excites the continuous light of fixed wave length；The laser coupled that described coupling device sends continuous wave laser is in one's hands
Hold in formula optic probe；Described hand-held optical probe carries out laser irradiation to biological tissue to be measured.Described hand-held optical is visited
Head includes optical lens, and described optical lens is used for optical signalling collection.
In such scheme, described ultrasound imaging module includes 2-D supersonic imaging apparatus, ultrasonic hand-held probe and location dress
Put.Described 2-D supersonic imaging apparatus is used for data sampling and processing and the reconstruction of 2-D ultrasonoscopy；Described ultrasonic hand-held is popped one's head in
For launching the ultrasound wave of characteristic frequency and receiving the ultrasonic signal that biological tissue to be measured passes back；Described positioner is used for tying
Close 2-D supersonic imaging apparatus and carry out the ultrasonic realtime imaging of 3-D.
In such scheme, described data processing module processes to become with reconstruction, ultrasonic module 3-D for the data of optical signalling
As reconstruction, optical imagery and 3-D ultra sonic imaging result registration.
In such scheme, system also includes that mechanical close module, described mechanical close module are used for encapsulating whole imaging system
System and data processing module.Described mechanical close module includes movable pulley, place position and draw-in groove, and described movable pulley is used for whole system
System is mobile, and place position is used for placing optical imagery module, ultrasound imaging module and data processing module, and draw-in groove is used for placing hand-held
Formula optic probe and ultrasonic hand-held probe.
Utilize the hand-held optical imaging in any of the above-described scheme and ultra sonic imaging multi-modal fusion imaging system, carry out many
The method of modality fusion imaging, comprises the following steps: when imaging, carries out optical imagery first with described optical imagery module,
Laser instrument excites the continuous light of fixed wave length, is coupled in hand-held optical probe by coupling device, and hand-held optical is popped one's head in
Biological tissue to be measured is carried out laser irradiation, the optical signalling of reception is transmitted back to data processing module and carries out at follow-up signal
Reason and image reconstruction；Then switching over, utilize described ultrasound imaging module to carry out ultra sonic imaging, ultrasonic hand-held probe is launched
The ultrasound wave of characteristic frequency also receives the ultrasonic signal that biological tissue to be measured passes back, 2-D supersonic imaging apparatus figure ultrasonic to 2-D
As carrying out data acquisition process and reconstruction；Data processing module combine 2-D ultrasonoscopy and positioner to carry out 3-D ultrasonic in real time
Imaging, and optical imagery and 3-D ultra sonic imaging are carried out result registration, display shows optical imagery, 3-D ultrasonoscopy respectively
Result after merging with the registration of optical imagery with ultrasonoscopy.
(3) beneficial effect
The present invention compared with prior art has the advantage that
1, the present invention provides a kind of hand-held optical imaging and ultra sonic imaging multi-modal fusion imaging system and method, can
To combine Optical imaging modalities and the advantage of 3-D ultrasound imaging modality, reflect more fully structure and physiological function information.
2, the imaging system that the present invention provides can be reached to circulate the effect of lifting mutually by modeling, obtained more accurately
Registration fusion image.
3, the imaging system that the present invention provides can carry out toy three-dimensional imaging.
Accompanying drawing explanation
Fig. 1 is the optical imagery according to one embodiment of the invention and ultra sonic imaging multi-modal fusion imaging system population structure
Schematic diagram.
Fig. 2 is the optical imagery according to one embodiment of the invention and ultra sonic imaging fusion process schematic diagram.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with specific embodiment, and reference
Accompanying drawing, the present invention is described in further detail.
Fig. 1 is that the structure of the optical imagery according to one embodiment of the invention and ultra sonic imaging multi-modal fusion imaging system is shown
Being intended to, as it is shown in figure 1, described hand-held optical imaging and ultra sonic imaging multi-modal fusion imaging system, this system includes: optics
Image-forming module, ultrasound imaging module, data processing module and mechanical close module, wherein:
Optical imagery module includes continuous wave laser, coupling device and hand-held optical probe, after continuous wave laser is
Level coupling device provides continuous laser source, and the present embodiment selects wavelength to be 785nm, and coupling device is that rear class hand-held optical is visited
Head provides the laser meeting biological tissue's irradiation safety, and hand-held optical probe carries out laser irradiation to biological tissue to be measured, right
Its internal fluorescent material excites, and utilizes its interior high sensitivity optical lens to carry out faint optics signals collecting simultaneously,
And the optical signalling received is transmitted back to data processing module carry out follow-up signal processing and image reconstruction registration.
Ultrasound imaging module includes 2-D supersonic imaging apparatus, ultrasonic hand-held probe and positioner, 2-D ultra sonic imaging
Equipment is used for data acquisition process and the reconstruction of 2-D ultrasonoscopy, and ultrasonic hand-held probe launches the ultrasound wave of characteristic frequency also
Receiving the ultrasonic signal that biological tissue to be measured passes back, ultrasound imaging module utilizes 2-D ultrasonoscopy and positioner to carry out 3-D
The reconstruction of ultrasonoscopy obtains the abundantest organizational information.
The apparatus assembly of whole imaging system is controlled by data processing module, receives what hand-held optical module gathered
Optical signalling also carries out data process and reconstruction, hand-held ultrasonic module is carried out 3-D imaging reconstruction, to optical imagery and 3-D
The result of ultra sonic imaging registrates.
Mechanical close module be used for whole imaging system and the placement of data processing module, the placement of plug-in display, for
Whole multi-modal fusion imaging device provides an airtight darkroom, and including movable pulley, place position and draw-in groove, movable pulley is for whole
Individual system moves, and place position is used for placing optical imagery module, ultrasound imaging module and data processing module, and draw-in groove is used for placing
Hand-held optical probe and ultrasonic hand-held are popped one's head in.
When imaging, carry out optical imagery first with hand-held optical probe, then switch over, utilize ultrasonic hand-held
Probe carries out the ultra sonic imaging of the degree of depth, and display shows optical imagery, 3-D ultrasonoscopy and optical imagery and ultrasonoscopy respectively
Registration merge after result.Optical imagery and ultra sonic imaging registration process such as Fig. 2, data processing module is respectively to receiving
Optical module and ultrasonic module information carry out image reconstruction, and the position that optically-based module obtains with ultrasonic module is believed with data
Breath carries out the deformable registration of image, extends finite element method by tissue specificity optical delivery model and self adaptation, obtains
Obtain optics and ultrasonic fusion image.
Particular embodiments described above, to the purpose of the present invention, technical scheme with there is vegetables effect to carry out further in detail
Describe in detail bright it should be understood that the foregoing is only the specific embodiment of the present invention, be not limited to the present invention, all
Within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. done, should be included in the protection of the present invention
Within the scope of.
Claims (10)
1. hand-held optical imaging and a ultra sonic imaging multi-modal fusion imaging system, including optical imagery module, ultrasonic one-tenth
As module and data processing module, described optical imagery module is for carrying out optical imagery to biological tissue to be measured；Described ultrasonic
Image-forming module is for carrying out ultra sonic imaging to biological tissue to be measured；Described data processing module and described optical imagery module and surpass
Acoustic imaging module connects respectively, processes with the data message sending described optical imagery module and ultrasound imaging module.
2. hand-held optical imaging as claimed in claim 1 and ultra sonic imaging multi-modal fusion imaging system, it is characterised in that
Described optical imagery module includes continuous wave laser, coupling device and hand-held optical probe.
3. hand-held optical imaging as claimed in claim 2 and ultra sonic imaging multi-modal fusion imaging system, it is characterised in that
Described continuous wave laser excites the continuous light of fixed wave length；The laser coupled that described coupling device sends continuous wave laser is in one's hands
Hold in formula optic probe；Described hand-held optical probe carries out laser irradiation to biological tissue to be measured.
4. hand-held optical imaging as claimed in claim 2 and ultra sonic imaging multi-modal fusion imaging system, it is characterised in that
Described hand-held optical probe includes optical lens, and described optical lens is used for optical signalling collection.
5. hand-held optical imaging as claimed in claim 1 and ultra sonic imaging multi-modal fusion imaging system, it is characterised in that
Described ultrasound imaging module includes 2-D supersonic imaging apparatus, ultrasonic hand-held probe and positioner.
6. hand-held optical imaging as claimed in claim 5 and ultra sonic imaging multi-modal fusion imaging system, it is characterised in that
Described 2-D supersonic imaging apparatus is used for data sampling and processing and the reconstruction of 2-D ultrasonoscopy；Described ultrasonic hand-held probe is used
In launching the ultrasound wave of characteristic frequency and receiving the ultrasonic signal that biological tissue to be measured passes back；Described positioner is used for combining
2-D supersonic imaging apparatus carries out the ultrasonic realtime imaging of 3-D.
7. hand-held optical imaging as claimed in claim 1 and ultra sonic imaging multi-modal fusion imaging system, it is characterised in that
Described data processing module processes and reconstruction, ultrasonic module 3-D imaging reconstruction, optical imagery and 3-for the data of optical signalling
D ultra sonic imaging result registrates.
8. hand-held optical imaging as claimed in claim 1 and ultra sonic imaging multi-modal fusion imaging system, it is characterised in that
System also includes that mechanical close module, described mechanical close module are used for encapsulating whole imaging system and data processing module.
9. hand-held optical imaging as claimed in claim 8 and ultra sonic imaging multi-modal fusion imaging system, it is characterised in that
Described mechanical close module includes movable pulley, place position and draw-in groove, and described movable pulley moves for whole system, and place position is used for
Placing optical imagery module, ultrasound imaging module and data processing module, draw-in groove is used for placing hand-held optical probe with hand-held
Formula ultrasonic probe.
10. utilize the hand-held optical imaging described in any one of claim 1-9 and ultra sonic imaging multi-modal fusion imaging system,
The method carrying out multi-modal fusion imaging, it is characterised in that when imaging, carries out optics first with described hand-held optical probe
Data are reached data processing module and carry out signal processing and image reconstruction by imaging；Then switch over, utilize described hand-held
Ultrasonic probe carries out ultra sonic imaging, data reaches data processing module and carries out 3-D imaging reconstruction；Data processing module is to optics
The result of imaging and 3-D ultra sonic imaging registrates, and display shows optical imagery, 3-D ultrasonoscopy and optical imagery respectively
Result after merging with the registration of ultrasonoscopy.
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Cited By (13)
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| CN107115098A (en) * | 2017-03-27 | 2017-09-01 | 北京大学 | Based on one-dimensional non-focusing and the double array scanning imaging devices of focusing ultrasound and method |
| CN108056821A (en) * | 2018-02-08 | 2018-05-22 | 北京数字精准医疗科技有限公司 | A kind of open fluorescence ultrasound fusion radiography navigation system |
| CN108185974A (en) * | 2018-02-08 | 2018-06-22 | 北京数字精准医疗科技有限公司 | A kind of endoscopic fluorescence ultrasound merges radiography navigation system |
| CN108186115A (en) * | 2018-02-08 | 2018-06-22 | 北京数字精准医疗科技有限公司 | Hand-held fluorescence ultrasound merges radiography navigation system |
| CN108403082A (en) * | 2018-01-24 | 2018-08-17 | 苏州中科先进技术研究院有限公司 | A kind of imaging in biological tissues system and imaging method |
| CN108992084A (en) * | 2018-09-07 | 2018-12-14 | 广东工业大学 | Use the method and CT- supersonic inspection device of CT system and ultrasonic system combined imaging |
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| WO2020043115A1 (en) * | 2018-08-28 | 2020-03-05 | 南京星顿医疗科技有限公司 | Detection device and detection method for combining tactile sensing and optical tomography imaging |
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