CN106214126B - A kind of detection device and detection method of bilirubin - Google Patents
A kind of detection device and detection method of bilirubin Download PDFInfo
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- CN106214126B CN106214126B CN201610587777.1A CN201610587777A CN106214126B CN 106214126 B CN106214126 B CN 106214126B CN 201610587777 A CN201610587777 A CN 201610587777A CN 106214126 B CN106214126 B CN 106214126B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0064—Body surface scanning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7221—Determining signal validity, reliability or quality
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/04—Babies, e.g. for SIDS detection
- A61B2503/045—Newborns, e.g. premature baby monitoring
Abstract
The present invention relates to a kind of detection device of bilirubin and detection method, which includes shell, and enclosure interior is equipped with bilirubin sensor, MCU, and bilirubin sensor is connect with MCU；Bilirubin sensor includes blue light collector and green light collector；Blue light collector includes the blue-light source that wavelength is 460nm and the photodiode for acquiring blue light, and the blue-light source that wavelength is 460nm and the photodiode for acquiring blue light are that encapsulation is integral；Green light collector includes the green light source that wavelength is 550nm and the photodiode for acquiring green light, and the green light source that wavelength is 550nm and the photodiode for acquiring green light are that encapsulation is integral；Blue light collector and green light collector position are parallel or point-blank.The detection device of bilirubin provided by the invention uses bilirubin sensor as the core component of the detection device of bilirubin, needs not rely on the Optical devices of profession, at low cost and easy for installation.
Description
Technical field
The present invention relates to bilirubin detection technique field, the detection device and detection method of especially a kind of bilirubin.
Background technique
Jaundice is serum mesobilirubin too high levels, the common clinical table for causing the tissues such as skin, sclera, mucous membrane to turn to be yellow
Existing, detecting jaundice at present is judged by detecting the concentration of serum mesobilirubin.Subcutaneous group of icterus neonatorum patient
The reflected value to the incident light that wavelength is 460nm is knitted, is consistently reduced with the increase of serum total bilirubin concentration, thus
The reflected value that the subcutaneous tissue at 460nm can be efficiently used percutaneously to measure Neonatal total bilirubin concentration.Due to blood
Lactoferrin also has strong absorption value at 460nm, thus in subcutaneous tissue hemoglobin also have to the reflectance spectrum of subcutaneous tissue it is aobvious
Person influences, and can interfere the percutaneous measurement of bilirubin.Because of absorption value of the hemoglobin at 550nm and the absorption at 460nm
It is worth interference that is identical, therefore eliminating hemoglobin with the method for subtracting the absorption value at 550nm in measuring instrument, to realize
Determination of bilirubin.
According to principles above, as long as measuring the light reflected value of 460nm and 550nm, the value of bilirubin can be calculated.
And the reflected value of light is measured, mainly realized by optical module.A kind of detection device of bilirubin currently on the market
Optical detecting module cardinal principle, be illustrated in fig. 1 shown below, the light source of use is blue-ray LED 11 and green light LED 12, and fiber optic bundle is
Two-way, fiber optic bundle other end using 500nm two to dividing mirror 13 to be divided, the light after light splitting is respectively radiated to blue light
On photodiode 14 and green light photodiode 15, to collect the data of needs, so that it may calculate the value of bilirubin.
The optical detecting module cost of this structure is very high, needs to rely on the Optical devices such as two of profession to dividing mirror, this
A little assembling parts degree of difficulty are also relatively high.
Summary of the invention
Therefore, the present invention provides a kind of detection devices of bilirubin, to solve the above problems.
The technical scheme is that a kind of detection device of bilirubin, including shell, the enclosure interior are equipped with gallbladder
Red pigment sensor, MCU, the bilirubin sensor are connect with the MCU；The bilirubin sensor includes blue light collector
With green light collector；The blue light collector includes the blue-light source that wavelength is 460nm and the photoelectricity two for acquiring blue light
Pole pipe, the blue-light source that the wavelength is 460nm and the photodiode for acquiring blue light are that encapsulation is integral；It is described green
Light collector includes the green light source that wavelength is 550nm and the photodiode for acquiring green light, and the wavelength is 550nm's
Green light source and photodiode for acquiring green light are that encapsulation is integral；The blue light collector and the green light acquire
Device position is parallel or point-blank.Above-mentioned MCU refers to CPU, RAM of computer, ROM, timer conter and more
On one chip, the computer of the chip-scale of formation is that details are not described herein again for existing matured product to kind I/O Interface integration.
Optionally, described for acquire the photodiode of blue light and the photodiode for acquiring green light to be to have
The photodiode of nano coating.
Optionally, bluetooth module is installed, the bluetooth module is connect with the MCU in the shell.
Optionally, power supply, the power supply and the bilirubin sensor, the MCU and institute are also equipped in the shell
State bluetooth module connection.
Optionally, the detection device of the bilirubin includes light hole, and rubber pad, the rubber are cased on the light hole
The area of pad is 20-30 times of the area of light hole；The rubber pad has reflective layer backwards to light hole on one side.
Optionally, the detection device of the bilirubin includes light hole, is equipped with plug on the light hole；The plug
Including cover, piston part and operation portion, what the cover, piston part and operation portion were integrated, there is interval between the cover and piston part,
There is protrusion on the piston part, the protrusion is located in the interval；The coupling part of the cover and the piston part, the protrusion
And the operation portion is free chamber respectively；There is the concave surface with the male cooperation in the light hole.
The present invention also provides a kind of detection methods of bilirubin, including, choose blue-light source, the wave that wavelength is 460nm
The green light source of a length of 550nm, the photodiode for acquiring blue light and the photodiode for acquiring green light；Make light
Electric collector: it by blue-light source that wavelength is 460nm and is used to acquire the photodiode of blue light and utilizes semiconductor packaging
Molding forms blue light collector；Wavelength for the green light source of 550nm and is used to acquire the photodiode of green light using partly
The molding of conductor encapsulation technology forms green light collector；By it is described see blue light collector it is parallel with green light collector or
It point-blank places, connection forms bilirubin sensor；Bilirubin sensor is connected into MCU, is placed in light hole
In shell, bilirubin detecting instrument is formed；Light hole is placed on skin, the bilirubin detecting instrument is started.
Preferably, choose wavelength be 460nm blue-light source, wavelength be 550nm green light source, for acquiring blue light
Photodiode and photodiode for acquiring green light include choosing blue led light source, wavelength that wavelength is 460nm to be
The green LED light source of 550nm, the photodiode with nano coating for acquiring blue light and for acquiring having for green light
The photodiode of nano coating.
Preferably, bilirubin sensor is connected into MCU, be placed in the shell with light hole, form bilirubin detector
Device further includes that MCU is connected bluetooth module；It is described that light hole is placed on skin, after starting the bilirubin detecting instrument
It further include connecting the bluetooth module with mobile phone.
Preferably, bilirubin sensor is connected into MCU, be placed in the shell with light hole, form bilirubin detector
It is described that light hole is placed on skin after device, it further include that selection area is light passing before starting the bilirubin detecting instrument
20-30 times of rubber pad of the area in hole；The rubber pad is coated into reflective layer on one side；One side with reflective layer is opposite
Light hole is placed on the light hole.
Preferably, the bilirubin sensor includes isolation current bar, is provided in the isolation current bar and successively sets
It is equipped with blue light collector and green light collector, the bilirubin covers disposed on sensor has signal transmission module, and current bar is isolated
It is equipped with insulating course between interior blue light collector and green light collector, the insulating course is equipped with partition panel；The isolation
The surface of current bar is also coated with OSP layers；The bottom of the isolation current bar is additionally provided with pedestal, and the pedestal is equipped with for inciting somebody to action
On the light hole for the detection device that isolation current bar is hingedly connected at the bilirubin；The signal transmission module includes circular
Multilayer board, with six elongated strip antennas of its midpoint circumferential array, each elongated strip in each multilayer board
Antenna includes the frame of rectangle, and each edge of the frame is towards the first arc sub-antenna for being provided centrally with arc and the
Two arc sub-antennas；The radius of the second arc sub-antenna is greater than the first arc sub-antenna；Each elongated strip antenna also wraps
The round sub-antenna being provided from each edge towards center is included, the radius of the circle sub-antenna is greater than the second arc day
The width of line, the circle sub-antenna is gradually reduced from both ends to center；The circle sub-antenna is made of carbofrax material；Institute
The end for stating frame is equipped with partition band, and the partition band is the material of non-conducting electric current, and the end of frame is disconnected；Justify two-by-two
A third sub-antenna is equipped between shape sub-antenna, one end of the third sub-antenna is equipped with the annular sub-antenna of circular ring shape,
The annular sub-antenna is set to the top of frame；The other end of the third sub-antenna is equipped with the 4th arc sub-antenna of arc,
The radius of three the 4th arc sub-antennas in each frame is identical；The center of the frame is equipped with a data transmission terminal
Mouthful, the data transmission port is electrically connected with three the 4th arc sub-antennas respectively；The bottom surface of the multilayer board also is provided with
The first connector corresponding with data transmission port；The third sub-antenna is equipped with multiple the second connectors being placed equidistant with；
The outer end of the multilayer board is equipped with a circle transmission line, and the transmission line is electrically connected with each sub-antenna；Multilayer board top
A support plate is equipped in face, multilayered printed back is equipped with shaft, and the shaft is electrically connected with support plate, the shaft
Lower end is equipped with outside antenna, and the outside antenna includes that there are three outer sub-antennas triangular in shape；The partition panel is a copper billet, described
With its midpoint, circumferential array has connector corresponding with six elongated strip antennas on partition panel；The connector and frame it is big
It is small identical；The quantity of second connector is N, and the length of the third sub-antenna is Lmm, the radius of the annular sub-antenna
For Kmm, then K=L/N.
Preferably, described for acquiring the photodiode of blue light and the photodiode for acquiring green light includes:
Time quantum for establishing connection at least one MCU, and carries out acquisition time record；Photochromic detection unit, for acquiring light
During source data, first light source data are acquired, and receive the second light source data of acquisition；Integral unit, being used for will be described
First light source data and second light source data carry out more session integration, obtain multiple light courcess data, wherein the integral unit is specific
Include: to make the difference unit, for by first light source data beginning acquisition time and second light source data beginning acquisition time, wave
Length makes the difference to obtain absolute value of the difference, the absolute value of the difference of wavelength of time；Capture unit, for according to the exhausted of the difference of the time
The wavelength information of corresponding light source data in the first light source data and second light source data is captured to value；Processing unit is used
In light source data corresponding in the first light source data and second light source data is carried out more session processing, the mostly light is obtained
Source data；The processing unit includes: processing subelement, for that will correspond in the first light source data and second light source data
Light source data handled according to the arrayed feature of more sessions, obtain the pulse code modulation data of more sessions；Coding is single
Member obtains the multiple light courcess data for encoding according to scheduled file format to the pulse code modulation data；Its
In, processing unit is compared according to the wavelength information of first light source data and second light source data, if the difference of wavelength is absolute
Value is greater than 10nm, then controls photochromic detection unit and detect first light source data and second light source data again.
The detection device of bilirubin provided by the invention uses bilirubin sensor as the core of the detection device of bilirubin
Center portion part needs not rely on the Optical devices of profession, at low cost and easy for installation.
Bilirubin is detected using the detection method of bilirubin provided by the invention, at low cost, accuracy is high.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of the detection device of existing bilirubin；
Fig. 2 is a kind of structural schematic diagram of the detection device of bilirubin provided by the invention；
Fig. 3 is a kind of concrete structure schematic diagram of the detection device of bilirubin provided by the invention；
Fig. 4 is a kind of structure of the detecting device schematic diagram of bilirubin with rubber pad provided by the invention；
Fig. 5 is a kind of structure of the detecting device schematic diagram of bilirubin with plug provided by the invention；
Fig. 6 is a kind of structure of the detecting device schematic diagram of the bilirubin with light hole provided by the invention.
Wherein, 11, blue-ray LED；12, green light LED；13, two to dividing mirror；14, blue photodiode；15, green light photoelectricity
Diode；16, shell；17, bilirubin sensor；18,MCU；19, blue light collector；20, green light collector；21, wavelength
For the blue-light source of 460nm；22, for acquiring the photodiode of blue light；23, wavelength is the green light source of 550nm；24, it uses
In the photodiode of acquisition green light；25, bluetooth module；26, power supply；27, light hole；28, rubber pad；29, reflective layer；30,
Cover；31, piston part；32, operation portion；33, raised；34, cavity；35, concave surface.
Specific embodiment
Technical solution of the present invention is described in detail with reference to the accompanying drawing.
The present invention provides a kind of detection devices of bilirubin, referring to fig. 2, including shell 16, the enclosure interior installation
There are bilirubin sensor 17, MCU18, the bilirubin sensor is connect with the MCU；The bilirubin sensor includes blue
Light collector 19 and green light collector 20；The blue light collector includes wavelength for the blue-light source 21 of 460nm and for adopting
Collect the photodiode 22 of blue light, the wavelength is the blue-light source 23 of 460nm and two pole of photoelectricity for acquiring the blue light
Pipe 24 is that encapsulation is integral；The green light collector includes the green light source that wavelength is 550nm and the light for acquiring green light
Electric diode, the green light source that the wavelength is 550nm and the photodiode for acquiring the green light are that encapsulation is integral
's；The blue light collector and green light collector position be it is parallel or point-blank, specifically can will be blue
Light collector and the green light collector are set to formation bilirubin sensor on one piece of circuit board.It is above-mentioned to be used to acquire blue light
Photodiode and photodiode for acquiring green light are preferably the photodiode for having nano coating, and selection can mistake
The photodiode with nano coating for filtering out the light of 550nm or 460nm can reduce the interference of the veiling glare in light source, increase
Add the accuracy of the detection device of bilirubin, veiling glare described herein refers to that light source contains due to there is error during fabrication
Light in addition to 550nm or 460nm, above-mentioned light source can choose LED light.Bluetooth module 25 is also equipped in shell,
Referring to Fig. 3, bluetooth module is connect with the MCU, can be transmitted the data in MCU in the form of a signal by bluetooth module
To mobile phone, more convenient people check and analyze, and the detection device of bilirubin can also not have to display screen, reduce bilirubin
The volume of detection device；Of course for convenient for observation, upper display screen can also be set according to design requirement.In order to facilitate power supply,
Power supply 26, the power supply and the bilirubin sensor, the MCU and the bluetooth module are preferably also equipped in the shell
Connection is easy to use further, it is also possible to which power switch, Operation switch etc. is arranged.
The detection device of bilirubin provided by the invention uses bilirubin sensor as the core of the detection device of bilirubin
Center portion part needs not rely on the Optical devices of profession, and at low cost and easy for installation, accuracy is high.
The detection device of bilirubin will avoid as far as possible ambient light from interfering to guarantee its accuracy, in order to prevent outside when in use
The interference of boundary's light, applicant have also done following design: as shown in figure 4, the detection device of bilirubin includes light hole 27, the light passing
Rubber pad 28 is cased on hole, the area of the rubber pad is 20-30 times of the area of light hole；The light passing backwards of the rubber pad
There is reflective layer 29 in hole on one side, due to the characteristic of rubber pad, contacts relative tight with human skin, is easy shading, and connect
It is relatively comfortable after touch, rubber pad backwards to light hole coat reflective layer on one side after, the light of light hole circumfusion can be reflected away,
To have ambient light interference when preventing detection, the accuracy of the detection device detection of bilirubin is influenced, is studied through test of many times, rubber
The area of rubber mat can meet using effect when being 20-30 times of the area of light hole.
The detection device of bilirubin due to there is a light hole for detection, dust and air be easy by light hole into
Enter inside the detection device of bilirubin, dust is easy accumulation over time, especially in the environment of there was dampness in the air, is attached to gallbladder
On the inner wall or sensor component of the detection device shell of red pigment, the accuracy of the detection device detection of bilirubin is influenced, is
This, applicant has done following design: referring to figs. 5 and 6, the detection device of the bilirubin includes light hole 27, the light passing
Plug is installed on hole；The plug includes cover 30, piston part 31 and operation portion 32, the cover 30, piston part 31 and operation portion
32 are integrated, and have interval between the cover and piston part, there is protrusion 33 on the piston part, and the protrusion is located at the interval
It is interior；The coupling part of the cover and the piston part, the protrusion, the piston part and the operation portion are free chamber 34 respectively；Institute
The concave surface 35 having in light hole with the male cooperation is stated, cooperation described herein, which refers to cooperating with convex shape, makes raised card
In concave surface.Dust can be blocked in outside light-transmitting opening by using plug, and the moisture in air be also not easily accessed it is logical
Unthreaded hole, so that the effective protection detection device of bilirubin uses accuracy, specifically, the cover of plug can shelter from it is logical
Unthreaded hole is further ensured that sealing in piston part insertion light hole, what operation portion made to remove and install in order to facilitate plug；On piston part
Concave surface cooperation in protrusion and light hole, can prevent only a few moisture from directly entering along light hole and piston part contact surface,
To be further ensured that the leakproofness of plug；In addition, the protrusion on piston part and the concave surface cooperation in light hole can prevent from carrying
Plug caused by vibrating in the process, which loosens, even to fall off, its leakproofness of image；Since the mobile performance of air is preferable, cover
The cavity of cavity and piston part between piston part is conducive to deformation when the insertion light-transmitting opening of piston part, to be easier to be inserted into；Protrusion
Cavity be conducive to stress bulging deformation, it is convenient to cooperate with concave surface；The cavity of operation portion is conducive to operation portion deformation, is preferably provided
In intermediate position, people are facilitated to press and by holding；In addition, the coupling part of the cover and the piston part, the protrusion, described
The cavity of piston part also helps damping in carrying process.
Preferably, the bilirubin sensor includes isolation current bar, is provided in the isolation current bar and successively sets
It is equipped with blue light collector and green light collector, the bilirubin covers disposed on sensor has signal transmission module, and current bar is isolated
It is equipped with insulating course between interior blue light collector and green light collector, the insulating course is equipped with partition panel；The isolation
The surface of current bar is also coated with OSP layers；The bottom of the isolation current bar is additionally provided with pedestal, and the pedestal is equipped with for inciting somebody to action
On the light hole for the detection device that isolation current bar is hingedly connected at the bilirubin；
The signal transmission module includes circular multilayer board, with its midpoint circumferential array in each multilayer board
Six elongated strip antennas, each elongated strip antenna include the frame of rectangle, the equal direction of each edge of the frame
It is provided centrally with the first arc sub-antenna and the second arc sub-antenna of arc；The radius of the second arc sub-antenna is greater than the
One arc sub-antenna；
Each elongated strip antenna further includes having the round sub-antenna being provided from each edge towards center, the round son
The radius of antenna is greater than the second arc sub-antenna, and the width of the circle sub-antenna is gradually reduced from both ends to center；The circle
Shape sub-antenna is made of carbofrax material；The end of the frame is equipped with partition band, and the partition band is the material of non-conducting electric current
Material disconnects the end of frame；It is equipped with a third sub-antenna between round sub-antenna two-by-two, the third sub-antenna
One end is equipped with the annular sub-antenna of circular ring shape, and the annular sub-antenna is set to the top of frame；The third sub-antenna it is another
End is equipped with the 4th arc sub-antenna of arc, and the radius of three the 4th arc sub-antennas in each frame is identical；It is described
The center of frame is equipped with a data transmission port, and the data transmission port is electrically connected with three the 4th arc sub-antennas respectively
It connects；The bottom surface of the multilayer board also is provided with the first connector corresponding with data transmission port；On the third sub-antenna
Equipped with multiple the second connectors being placed equidistant with；The outer end of the multilayer board be equipped with one circle transmission line, the transmission line with
Each sub-antenna electrical connection；A support plate is equipped in multilayered printed plate top surface, multilayered printed back is equipped with shaft, described
Shaft is electrically connected with support plate, and the lower end of the shaft is equipped with outside antenna, and the outside antenna includes that there are three triangular in shape outer
Sub-antenna；
The partition panel is a copper billet, is had and six elongated strip antennas pair on the partition panel with its midpoint circumferential array
The connector answered；The connector is identical as the size of frame；The quantity of second connector is N, the third sub-antenna
Length be Lmm, the radius of the annular sub-antenna is Kmm, then K=L/N.
The present invention can avoid between blue light collector and green light collector in isolation current bar by above structure
Light collection interfere with each other, to improve the accuracy of detection.
Preferably, described for acquiring the photodiode of blue light and the photodiode for acquiring green light includes:
Time quantum for establishing connection at least one MCU, and carries out acquisition time record；
Photochromic detection unit acquires first light source data during acquiring light source data, and receives the of acquisition
Two light source datas；
Integral unit obtains mostly light for the first light source data and second light source data to be carried out more session integration
Source data, wherein the integral unit specifically includes:
Unit is made the difference, for by the beginning acquisition time of first light source data and second light source data when starting acquisition
Between, wavelength makes the difference to obtain the absolute value of the difference of time, the absolute value of the difference of wavelength；
Capture unit, for capturing the first light source data and second light source number according to the absolute value of the difference of the time
The wavelength information of corresponding light source data in；
Processing unit, for light source data corresponding in the first light source data and second light source data to be carried out mostly light
Road processing, obtains the multiple light courcess data；
The processing unit includes: processing subelement, and being used for will be right in the first light source data and second light source data
The light source data answered is handled according to the arrayed feature of more sessions, obtains the pulse code modulation data of more sessions；
Coded sub-units are obtained for encoding according to scheduled file format to the pulse code modulation data
The multiple light courcess data；
Wherein, processing unit is compared according to the wavelength information of first light source data and second light source data, if wavelength
Absolute value of the difference be greater than 10nm, then control photochromic detection unit and detect first light source data and second light source data again.
The present invention can detect and identify wavelength for the light source of multi-frequency, light environment complexity by above-mentioned apparatus,
To identify blue light in light source and green light so that it is determined that bilirubin, and by first light source data and second light source data
A multiple light courcess data are integrated into, so that two light source informations be exported with being combined into one, transinformation is saved, is
Data transmission is optimized.
The present invention also provides a kind of detection methods of bilirubin, including, choose blue-light source, the wave that wavelength is 460nm
The green light source of a length of 550nm, the photodiode for acquiring blue light and the photodiode for acquiring green light, above-mentioned member
Device is that existing component, people can select purchase as needed in the market；Production photoelectric gathering apparatus: it is by wavelength
The blue-light source of 460nm and photodiode for acquiring blue light utilize semiconductor packaging molding, form blue gloss
Storage；By green light source that wavelength is 550nm and it is used to acquire the photodiode of green light using semiconductor packaging molding,
Form green light collector；Encapsulation technology is so that mature technology, and details are not described herein again, sees blue light collector and green for described
Light collector is parallel or point-blank places, connection forms bilirubin sensor；By it is described see blue light collector and
Green light collector is parallel or point-blank places, the ratio for the light that blue light collector and green light collector can be made to acquire
Example is almost consistent, makes to measure more acurrate；Bilirubin sensor is connected into MCU, is placed in the shell with light hole, it is red to form gallbladder
Plain detecting instrument；Light hole is placed on skin, starts the bilirubin detecting instrument, bilirubin detecting instrument is by the number of acquisition
According to by handling storage or reaching on computer or mobile phone so that people check.
In order to further increase bilirubin detection accuracy, choose wavelength be 460nm blue-light source, wavelength be
The green light source of 550nm, the photodiode for acquiring blue light and the photodiode for acquiring green light include choosing wave
The blue led light source of a length of 460nm, green LED light source that wavelength is 550nm, for acquire blue light with nano coating
Photodiode and the photodiode with nano coating for acquiring green light, LED light source luminous efficiency is high, is conducive to photoelectricity
Diode receives, and selection can filter out the photodiode with nano coating of the light of 550nm or 460nm, can reduce
The interference of veiling glare in light source increases the accuracy of the detection method of bilirubin.
In order to facilitate use, bilirubin sensor is connected into MCU, is placed in the shell with light hole, bilirubin is formed
Detecting instrument further includes that MCU is connected bluetooth module；It is described that light hole is placed on skin, start the bilirubin detector
It further include connecting the bluetooth module with mobile phone, the data that bronze drum bluetooth module will test reach mobile phone, can facilitate after device
Observation, furthermore can also be downloaded in advance on mobile phone bilirubin data analysis APP, in time to jaundice disease forecasting, issue suggest.
Preferably, bilirubin sensor is connected into MCU, be placed in the shell with light hole, form bilirubin detector
It is described that light hole is placed on skin after device, it further include that selection area is light passing before starting the bilirubin detecting instrument
20-30 times of rubber pad of the area in hole；The rubber pad is coated into reflective layer on one side；One side with reflective layer is opposite
Light hole is placed on the light hole, is in this way reflected the light of light hole circumfusion by that can have the rubber pad of reflective layer
Fall, to prevent having ambient light interference when detection, influences the accuracy of the detection device detection of bilirubin.
Above-described embodiment is the illustration invented, and it is special should not to describe limitation with the exemplary embodiments of specification and attached drawing
The protection scope of economic rights.
The preferred embodiments of the disclosure and embodiment are explained in detail above in conjunction with attached drawing, but it is of the invention
It is not limited to the above embodiment and embodiment can also not take off within the knowledge of those skilled in the art
Various changes can be made under the premise of from present inventive concept.
Claims (6)
1. a kind of detection device of bilirubin, which is characterized in that including shell, the enclosure interior is equipped with bilirubin sensing
Device, MCU, the bilirubin sensor are connect with the MCU；
The bilirubin sensor includes blue light collector and green light collector；
The blue light collector includes wavelength for the blue-light source of 460nm and the photodiode for acquiring blue light, described
The blue-light source that wavelength is 460nm and the photodiode for acquiring blue light are that encapsulation is integral；
The green light collector includes wavelength for the green light source of 550nm and the photodiode for acquiring green light, described
The green light source that wavelength is 550nm and the photodiode for acquiring green light are that encapsulation is integral；
The blue light collector and the green light collector position are parallel or point-blank；
The detection device of the bilirubin includes light hole, is equipped with plug on the light hole；
The plug includes cover, piston part and operation portion, what the cover, piston part and operation portion were integrated, the cover and plug
There is interval between portion, there is protrusion on the piston part, the protrusion is located in the interval；
The coupling part of the cover and the piston part, the protrusion and the operation portion are free chamber respectively；
There is the concave surface with the male cooperation in the light hole.
2. the detection device of bilirubin according to claim 1, which is characterized in that described for acquiring the photoelectricity two of blue light
Pole pipe and photodiode for acquiring green light are the photodiode with nano coating.
3. the detection device of bilirubin according to claim 1, which is characterized in that be equipped with bluetooth mould in the shell
Block, the bluetooth module are connect with the MCU.
4. the detection device of bilirubin according to claim 3, which is characterized in that it is also equipped with power supply in the shell,
The power supply is connect with the bilirubin sensor, the MCU and the bluetooth module.
5. the detection device of bilirubin according to claim 1-4, which is characterized in that be cased on the light hole
Rubber pad, the area of the rubber pad are 20-30 times of the area of light hole；
The rubber pad has reflective layer backwards to light hole on one side.
6. the detection device of bilirubin according to claim 1-4, which is characterized in that the bilirubin sensor
Include isolation current bar, be provided in the isolation current bar and be disposed with blue light collector and green light collector,
The bilirubin covers disposed on sensor has a signal transmission module, be isolated the blue light collector in current bar and green light collector it
Between be equipped with insulating course, the insulating course be equipped with partition panel；The surface of the isolation current bar is also coated with OSP layers；It is described every
Bottom from current bar is additionally provided with pedestal, and the pedestal, which is equipped with, is hingedly connected at the bilirubin for current bar will to be isolated
On the light hole of detection device；
The signal transmission module includes circular multilayer board, with its midpoint circumferential array six in each multilayer board
Elongated strip antenna, each elongated strip antenna include the frame of rectangle, and each edge of the frame is towards center
It is provided with the first arc sub-antenna and the second arc sub-antenna of arc；The radius of the second arc sub-antenna is greater than the first arc
Shape sub-antenna；
Each elongated strip antenna further includes having the round sub-antenna being provided from each edge towards center, the circle sub-antenna
Radius be greater than the second arc sub-antenna, it is described circle sub-antenna width be gradually reduced from both ends to center；The round son
Antenna is made of carbofrax material；The end of the frame is equipped with partition band, and the partition band is the material of non-conducting electric current,
The end of frame is disconnected；A third sub-antenna, one end of the third sub-antenna are equipped between round sub-antenna two-by-two
Annular sub-antenna equipped with circular ring shape, the annular sub-antenna are set to the top of frame；The other end of the third sub-antenna is set
There is the 4th arc sub-antenna of arc, the radius of three the 4th arc sub-antennas in each frame is identical；The frame
Center be equipped with a data transmission port, the data transmission port is electrically connected with three the 4th arc sub-antennas respectively；Institute
The bottom surface for stating multilayer board also is provided with the first connector corresponding with data transmission port；The third sub-antenna is equipped with more
A the second connector being placed equidistant with；The outer end of the multilayer board is equipped with a circle transmission line, the transmission line and every height
Antenna electrical connection；In multilayered printed plate top surface be equipped with a support plate, multilayered printed back be equipped with shaft, the shaft with
Support plate electrical connection, the lower end of the shaft are equipped with outside antenna, and the outside antenna includes that there are three outer sub-antennas triangular in shape；
The partition panel is a copper billet, is had on the partition panel with its midpoint circumferential array corresponding with six elongated strip antennas
Connector；The connector is identical as the size of frame；The quantity of second connector is N, the length of the third sub-antenna
Degree is Lmm, and the radius of the annular sub-antenna is Kmm, then K=L/N.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610587777.1A CN106214126B (en) | 2016-07-22 | 2016-07-22 | A kind of detection device and detection method of bilirubin |
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| CN201610587777.1A CN106214126B (en) | 2016-07-22 | 2016-07-22 | A kind of detection device and detection method of bilirubin |
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| CN106214126B true CN106214126B (en) | 2019-03-29 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018208233A1 (en) * | 2017-05-12 | 2018-11-15 | National University Of Singapore | Noninvasive optical sensor for analyzing a level of a substance in a subject by illuminating the sclera |
| CN107966410A (en) * | 2017-12-20 | 2018-04-27 | 深圳乐普智能医疗器械有限公司 | Bilirubin measuring device |
| CN110368602B (en) * | 2019-09-04 | 2021-01-15 | 河南科技大学第一附属医院 | Infant jaundice phototherapy equipment with multiple light sources |
| CN112971708B (en) * | 2019-12-12 | 2022-07-15 | 上海交通大学 | Bilirubin noninvasive detection device based on skin fluorescence spectrum analysis |
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|---|---|---|---|---|
| BR9606008A (en) * | 1996-12-06 | 1998-09-08 | Cunha Jose Carlos Da | Non-invasive neonatal jaundice analyzer |
| US6847835B1 (en) * | 1999-03-31 | 2005-01-25 | Minolta Co., Ltd. | Transcutaneous bilirubin concentration measuring apparatus and a measurement data checking plate for use with the same |
| CN102906559A (en) * | 2010-05-27 | 2013-01-30 | 皇家飞利浦电子股份有限公司 | Apparatus and method for measuring analyte such as bilirubin, using light |
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2016
- 2016-07-22 CN CN201610587777.1A patent/CN106214126B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9606008A (en) * | 1996-12-06 | 1998-09-08 | Cunha Jose Carlos Da | Non-invasive neonatal jaundice analyzer |
| US6847835B1 (en) * | 1999-03-31 | 2005-01-25 | Minolta Co., Ltd. | Transcutaneous bilirubin concentration measuring apparatus and a measurement data checking plate for use with the same |
| CN102906559A (en) * | 2010-05-27 | 2013-01-30 | 皇家飞利浦电子股份有限公司 | Apparatus and method for measuring analyte such as bilirubin, using light |
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