CN106137170A - A kind of intelligent foot shock system based on biofeedback - Google Patents
A kind of intelligent foot shock system based on biofeedback Download PDFInfo
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- CN106137170A CN106137170A CN201610651789.6A CN201610651789A CN106137170A CN 106137170 A CN106137170 A CN 106137170A CN 201610651789 A CN201610651789 A CN 201610651789A CN 106137170 A CN106137170 A CN 106137170A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K29/00—Other apparatus for animal husbandry
- A01K29/005—Monitoring or measuring activity, e.g. detecting heat or mating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/1104—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb induced by stimuli or drugs
- A61B5/1105—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb induced by stimuli or drugs of laboratory animals, e.g. activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/1118—Determining activity level
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
- A61B5/165—Evaluating the state of mind, e.g. depression, anxiety
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6868—Brain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
Abstract
The present invention provides a kind of intelligent foot shock system based on biofeedback, device and animal behavior supervising device is controlled including intelligent controlling device, bio-feedback arrangement, electric shock, wherein, described bio-feedback arrangement, for gathering physiological activity information and the mental activity information of animal, described physiological activity information includes that heartbeat data, described mental activity information include activity data；Described animal behavior supervising device, for gathering the behavior signal of animal, analyzes and obtains behavioristics's data；Described intelligent controlling device, for according to described physiological activity information, mental activity information and behavioristics's data genaration electric shock instruction；Described electric shock controls device, for shocking by electricity animal according to described electric shock instruction.Present invention achieves the intelligent foot shock of specific region and time phase.
Description
Technical field
The present invention is about behavioristics's technical field, especially with regard to ethological research equipment, is concretely a kind of base
Intelligent foot shock system in biofeedback.
Background technology
The organism such as rat or mice itself is considered as a resistance, when giving certain voltage, it will produce electric current,
This electric current reach some strength discomfort can be caused even to detest, psychology and the physiological reaction such as frightened, such as in behavior due to
Detest can produce escape, freeze, dart, the reaction such as whipping, react physiologically there will be corticosterone risings, palpitating speed etc..
This pernicious stimulation typically is used for studying award and the neuromechanism of punishment and conditioned fear and memory at neuroscience field
Neural circuitry research.
The aversive response probing into big mice in behavioristics typically takes the mode of electric shock.Electric shock is for big mice
One strong pernicious stimulation.Real time position preference and conditioned fear behavioristics device etc. all make use of animal for pernicious stimulation
Avoidance response carry out scientific research.
Real time position preference is two or three that animal is placed in pernicious stimulation or positive sexual stimulus and neutral stimulus
Connection experimental box in, by see animal experimental box residence time under which kind of environment read animal detest or hobby
Mental activity, this is generally used for research award neuromechanism.
Another kind of similar device is conditioned fear behavioristics device, this device can using sound or environmental information as
Unconditioned stimulus combines upper foot shock and studies the animal conditioned fear acquistion for pernicious stimulation as conditional stimulus.But
Be above two kind experimental provision be the finest for the time of pernicious stimulation and the regulation and control in space.
Typically with the mental status of changes in heart rate reflection animal on the physiological reaction of big mice, at frightened, the shape of anxiety
Under state, the heart beating of animal there will be and dramatically increases.But this increase cannot indicate " psychological " reaction of animal completely, best
Scheme need for the activity combining neuron to assess the mental status of animal.
On the one hand real time position preference and foot shock case cannot realize the foot stimulating in special time and space, both
Device can only select the foot shock in space on a large scale, such foot shock to be only applicable to the interior electricity without selecting of behavioristics's device
Hit, be such as no problem when an only mice in a device, but when device having 2 or during above mice,
Cannot be carried out the stimulation of selective particular space and time.
On the other hand, both behavioristicss device cannot accomplish the intensity that intelligent control stimulates, and for animal, some is specific
Behavior and physiological status cannot be carried out sensitive feedback thus control electric shock.Typically can only be manually set a program according to spy
Fixed time interval and intensity implement electric shock, but toy is in a kind of kinestate continuously, the most such specific
Program can not be adjusted in real time according to the instant behavior reaction of animal and physiology, mental status, can only implement on sequencing ground
Electric shock.Active state specific for mice, as static or jump and still run, and specific mental status, be noting,
Judge, decision-making or frightened, happy or sad, it is impossible to carry out electric shock control real-time, accurate.
Summary of the invention
For the above-mentioned technical problem overcoming prior art to exist, the invention provides a kind of intelligence based on biofeedback
Foot shock system, controls device and animal behavior supervising device including intelligent controlling device, bio-feedback arrangement, electric shock,
The data of the physiology of animal, mental status and behavior state, intelligence control is obtained from bio-feedback arrangement and behavioristics's supervising device
These Data Integrations are converted into computer language and send electric shock instruction to electric shock control device by device processed, it is achieved for animal
Intelligent foot shock effect, changes by animal behavior and physical signs fed back through the signal of intelligent controlling device, becomes
Become attainable voltage with or without the control with amplitude, recycle selectable electric shock control device realize for animal in activity
Casing gives the foot shock in special time and space, it is achieved that specific region and the intelligent foot shock of time phase.
It is an object of the present invention to provide a kind of intelligent foot shock system based on biofeedback, described system includes
Intelligent controlling device, bio-feedback arrangement, electric shock control device and animal behavior supervising device,
Wherein, described bio-feedback arrangement, for gathering physiological activity information and the mental activity information of animal, described
Physiological activity information include that heartbeat data, described mental activity information include activity data；
Described animal behavior supervising device, for gathering the behavior signal of animal, analyzes and obtains behavioristics's data；
Described intelligent controlling device, for according to described physiological activity information, mental activity information and behavioristics
Data genaration electric shock instruction；
Described electric shock controls device, for shocking by electricity animal according to described electric shock instruction.
In a preferred embodiment of the invention, described bio-feedback arrangement includes heart rate survey meter, electrode and many
Channel signal analyzes module, wherein, described heart rate survey meter, for reading the heartbeat data of animal；It is implanted to the brain of animal
The electrode of interior target area, for recording the activity data of animal nerve unit；Described Multi-channel signal analysis module, for collecting also
Heartbeat data described in integration and activity data, and by intelligence the most described to described heartbeat data and active data transmission
Control device.
In a preferred embodiment of the invention, described animal behavior supervising device includes video camera, video frequency collection card
And behavior analysis module, wherein, described video camera, for shooting animal behavior signal in electric shock experimental box, described
Behavior signal include specific action, duration, action time of origin and spatial information, and by described behavior letter
Number by described video frequency collection card transmission to the most described behavior analysis module；Described behavior analysis module, is used for analyzing institute
The behavior signal stated obtains behavioristics's data, and by described behavioristics's data transmission to described intelligent controlling device.
In a preferred embodiment of the invention, described intelligent controlling device includes: the first acquisition module, is used for obtaining
The physiological activity information of animal and mental activity information；Second acquisition module, for obtaining behavioristics's data of animal；Coding
Module, for described behavioristics's data are encoded, the behavioristics's data after being encoded；Electric shock directive generation module,
Behavioristics's data after analyzing described physiological activity information, mental activity information and coding, generate electric shock instruction.
In a preferred embodiment of the invention, described electric shock controls device and includes and described intelligent controlling device phase
Wire that the power supply that is connected with described signal input line of signal input line connected is connected with described power supply and with institute
State the foot shock plate that wire is connected.
In a preferred embodiment of the invention, described foot shock plate includes circuit board and a plurality of conduction rustless steel
Bar, described conduction stainless steel strip is arranged side by side.
In a preferred embodiment of the invention, described wire is a plurality of.
In a preferred embodiment of the invention, described conduction stainless steel strip is identical with the number of described wire, and
Connect one to one.
In a preferred embodiment of the invention, it is spaced apart 2.5 millimeters between described conduction stainless steel strip.
In a preferred embodiment of the invention, described conduction stainless steel strip is 16.
In a preferred embodiment of the invention, a diameter of 6 millimeters of described conduction stainless steel strip, a length of 180 millis
Rice.
The beneficial effects of the present invention is, it is provided that a kind of intelligent foot shock system based on biofeedback, from biology
Feedback device and behavioristics's supervising device obtain the physiology of animal, mental status and the data of behavior state, intelligent controlling device
These Data Integrations are converted into computer language and send electric shock instruction to electric shock control device, it is achieved for the intellectuality of animal
Foot shock effect, changes by animal behavior and physical signs fed back through the signal of intelligent controlling device, and becoming can be real
Existing voltage with or without the control with amplitude, recycle selectable electric shock control device realize for animal in active box
Give the foot shock in special time and space, it is achieved that specific region and the intelligent foot shock of time phase.
For the above and other objects, features and advantages of the present invention can be become apparent, preferred embodiment cited below particularly,
And coordinate institute's accompanying drawings, it is described in detail below.
Accompanying drawing explanation
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
In having technology to describe, the required accompanying drawing used is briefly described, it should be apparent that, the accompanying drawing in describing below is only this
Some embodiments of invention, for those of ordinary skill in the art, on the premise of not paying creative work, it is also possible to
Other accompanying drawing is obtained according to these accompanying drawings.
The structured flowchart of a kind of based on biofeedback the intelligent foot shock system that Fig. 1 provides for the embodiment of the present invention；
Biofeedback dress in a kind of based on biofeedback the intelligent foot shock system that Fig. 2 provides for the embodiment of the present invention
The structured flowchart put；
Animal behavior prison in a kind of based on biofeedback the intelligent foot shock system that Fig. 3 provides for the embodiment of the present invention
The structured flowchart of control device；
Based Intelligent Control dress in a kind of based on biofeedback the intelligent foot shock system that Fig. 4 provides for the embodiment of the present invention
The structured flowchart put；
In a kind of based on biofeedback the intelligent foot shock system that Fig. 5 provides for the embodiment of the present invention, electric shock controls dress
The structured flowchart put；
The structural representation of intelligent foot shock system based on biofeedback in the specific embodiment that Fig. 6 provides for the present invention
Figure；
In the specific embodiment that Fig. 7 provides for the present invention, electric shock controls the connection diagram of device；
The circuit board of selectivity electric shock and the combination signal of conducting metal rod in the specific embodiment that Fig. 8 provides for the present invention
Figure.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Describe, it is clear that described embodiment is only a part of embodiment of the present invention rather than whole embodiments wholely.Based on
Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under not making creative work premise
Embodiment, broadly falls into the scope of protection of the invention.
The electric shock of specific region and time phase for probing into animal preference and memory has an important function, but up till now
Till there is no the electric shock device of exactly accurate room and time specific site.Therefore, the present invention, will based on bio-feedback arrangement
Animal behavior and physical signs fed back through intelligent controlling device signal conversion, become attainable voltage with or without with amplitude
Control, recycle selectable electric shock and control device and realize in active box, giving special time and space for animal
Foot shock.
The structured flowchart of a kind of based on biofeedback the intelligent foot shock system that Fig. 1 provides for the embodiment of the present invention,
As shown in Figure 1, described system includes that intelligent controlling device 10, bio-feedback arrangement 20, electric shock control device 30 and animal
Behavior monitoring device 40.
Wherein, described bio-feedback arrangement 20, for gathering physiological activity information and the mental activity information of animal, institute
The physiological activity information stated includes that heartbeat data, described mental activity information include activity data.In specific embodiment
In, animal can sized by Mus, be positioned at Behavior Test casing of the prior art.Fig. 2 is the structured flowchart of bio-feedback arrangement.
Described animal behavior supervising device 40, for gathering the behavior signal of animal, analyzes and obtains behavioristics's data.Figure
3 is the structured flowchart of animal behavior supervising device.
Described intelligent controlling device 10, for according to described physiological activity information, mental activity information and behavior
Learn data genaration electric shock instruction.Fig. 4 is the structured flowchart of intelligent controlling device.
Described electric shock controls device 30, for shocking by electricity animal according to described electric shock instruction.Fig. 5 is electric shock control
The structured flowchart of device processed.
As it appears from the above, the invention provides intelligent foot shock system based on biofeedback, it is a kind of big mice
The accurate electric shock device of room and time is carried out under specific state.This device, will be dynamic by adding a set of bio-feedback arrangement
Behavior and the physical signs of thing are converted into computer language, through signal analysis and the output of stimulation instructions of intelligent controlling device
By the intensity of electric shock, the time, spacing wave through electric shock control device realize voltage size, with or without and voltage selectivity
Output carries out the foot stimulating in accurate intensity, time, space to big mice, thus sensitiveer reflection neuron regulates and controls and god
Scientific exploration through loop active situation.
Biofeedback dress in a kind of based on biofeedback the intelligent foot shock system that Fig. 2 provides for the embodiment of the present invention
The structured flowchart put, as shown in Figure 2, bio-feedback arrangement 20 includes that heart rate survey meter 21, electrode 22 and multi channel signals divide
Analysis module 23.
Wherein, described heart rate survey meter 21, for reading the heartbeat data of animal；
It is implanted to the electrode 22 of target area in the brain of animal, for recording the activity data of animal nerve unit；
Described Multi-channel signal analysis module 23, for the heartbeat data described in collection integration and activity data,
And by intelligent controlling device the most described to described heartbeat data and active data transmission.
Heart rate survey meter reflects the heart rate of mice by beating of mice strength tremulous pulse, as the one of big mice physiological activity
Item index.It is implanted to the electrode of target area in the brain of animal from mouse brain, then obtain the neuron signal of telecommunication carry out reflection nerve
Unit's irritability information.Heartbeat data and the neuron activity data of mice are collected and integrate and export by bio-feedback arrangement
To intelligent controlling device, intelligent controlling device passes judgment on physiology and the mental activity state of mice according to these two indexs, in conjunction with
Behavioral reaction, gives the electric shock under the mice specific physiology of specific site special time, behavioristics's state.
Animal behavior prison in a kind of based on biofeedback the intelligent foot shock system that Fig. 3 provides for the embodiment of the present invention
The structured flowchart of control device, from the figure 3, it may be seen that described animal behavior supervising device 40 includes video camera 41, video frequency collection card 42
And behavior analysis module 43.Animal behavior supervising device real-time recording and the behavior reaction of analyzing animal, and signal is transmitted
To intelligent controlling device.
Wherein, described video camera 41, for shooting animal behavior signal in electric shock experimental box, described behavior letter
Number include specific action, duration, action time of origin and spatial information, and described behavior signal is passed through institute
Video frequency collection card 42 transmission stated is to described behavior analysis module；
Described behavior analysis module 43, obtains behavioristics's data for analyzing described behavior signal, and by described
Behavioristics's data transmission is to described intelligent controlling device.
Based Intelligent Control dress in a kind of based on biofeedback the intelligent foot shock system that Fig. 4 provides for the embodiment of the present invention
The structured flowchart put, as shown in Figure 4, described intelligent controlling device 10 includes:
First acquisition module 11, for obtaining physiological activity information and the mental activity information of animal；
Second acquisition module 12, for obtaining behavioristics's data of animal；
Coding module 13, for described behavioristics's data are encoded, the behavioristics's data after being encoded；
Electric shock directive generation module 14, after analyzing described physiological activity information, mental activity information and coding
Behavioristics's data, generate electric shock instruction.
In a particular embodiment, intelligent controlling device passes through signal and the animal of a computer generalization biofeedback
Behavior signal, carries out signal analysis, and the signal analyzed is changed into stimulation instructions transmission to control of shocking by electricity by algorithm
Device.Signal can be processed from the following aspects, in the first subordinate act, receives the row from animal behavior supervising device
For signal, encoding for every kind of behavior with computer language, such as 01 represents and freezes reaction, and 00 represents and runs behavior, and 10
Represent jump behavior etc.；Second from physical signs, receives the signal from bio-feedback arrangement and inputs, such as increased heart rate
Degree, the degree etc. of neuronal excitation.Stimulation instructions can control output voltage from the following aspects, and one is to stimulate
Intensity, voltage available size controls；Second is to stimulate site, can combine upper motor control by controlling 16 output lines
The independent current source of device realizes；3rd is the time point stimulated, and this can be tested by controlling independent current source opening and closing.
In a kind of based on biofeedback the intelligent foot shock system that Fig. 5 provides for the embodiment of the present invention, electric shock controls dress
The structured flowchart put, as shown in Figure 5, described electric shock controls what device 30 included being connected with described intelligent controlling device 10
Wire 33 that the power supply 32 that signal input line 31 is connected with described signal input line is connected with described power supply and with institute
State the foot shock plate 34 that wire is connected.
In a particular embodiment, foot shock plate includes circuit board and a plurality of conduction stainless steel strip, conducts electricity stainless
Steel bar is arranged side by side.Wire is a plurality of, and conduction stainless steel strip is identical with the number of described wire, and connects one to one.Tool
Body, it is spaced apart 2.5 millimeters between described conduction stainless steel strip.Described conduction stainless steel strip is 16.Described leads
Electricity a diameter of 6 millimeters of stainless steel strip, a length of 180 millimeters.
That is, electric shock controls device is responsible for implementing intelligent controlling device about voltage strength, the output of voltage selectivity
To foot shock plate.Foot shock plate (is applicable to mice, as rat the most in proportion by 16 diameter 6mm, interval 2.5mm
Suitably increase), the conduction stainless steel strip of a length of 180mm forms side by side.Use circuit board equally with similar diameter and
Away from getting out 16 holes, make each Kong Nengyu metal bar corresponding, and connect power supply by the upper conductor wire of welding.Each wire is all
It is individually power supply, so can realize the multiple energising combination of 16 wires, electric shock site can be confined to before and after's pawl, lift
One example, when needs carry out Mus rear solid end electric shock, then two metal bars only needing mice rear solid end to ride over give certain voltage, that
The electric current produced can stimulate to mice rear solid end, can give mice electricity in various degree by adjusting voltage amplitude difference simultaneously
Hit impression.
As above being based on biofeedback the intelligent foot shock system that the present invention provides, this device is by adding a set of life
Thing feedback device, is converted into computer language by behavior and the physical signs of animal, through the signal analysis of intelligent controlling device
The intensity of electric shock, time, spacing wave are controlled device through electric shock and realize the size of voltage, have by the output with stimulation instructions
Nothing and the output of voltage selectivity carry out the foot stimulating in accurate intensity, time, space to big mice, thus sensitiveer
Reflection neuron regulation and control and the scientific exploration of neural circuitry active situation.
Below in conjunction with specific embodiment, technical scheme is discussed in detail.The concrete reality that Fig. 6 provides for the present invention
Execute the structural representation of intelligent foot shock system based on biofeedback in example, it will be appreciated from fig. 6 that in this specific embodiment
In, this system includes that intelligent controlling device 101, bio-feedback arrangement 102, animal behavior supervising device 103, electric shock control device
104, mice is positioned in Behaviors survey casing 105.
Intelligent controlling device obtains mice physiological status and behavior state from bio-feedback arrangement and behavioristics's supervising device
Data, and these Data Integrations are converted into computer language to electric shock control device send electric shock instruction, this instruction includes
The information such as electric shock intensity, site, time, it is achieved for the intelligent foot shock effect of animal.
Bio-feedback arrangement 102 is for gathering the information of animal physiological and mental activity, and physiological activity is made with animal heart rate
For index, the Neural spike train state that mental activity is then rolled into a ball using the brain district of specific site or core is as index.This device includes the heart
Rate survey meter 106, electrode 107, multi-channel signal acquiring analyze software 108.Heart rate survey meter 106 can be by carotid jumping
Move and read animal heart rate data, be used for reflecting the emotional states such as mice fear, anxiety.Electrode 107 is implanted to laboratory animal
Target area in brain, be recorded the change of neuron by multiple electrode array, analyzes software 108 with multi-channel signal acquiring and is analyzed,
The corresponding animal behavior reaction when accepting the foot shock of special time and space, as freezed, darting, the reaction such as jump permissible
Probe into the movable dependency with certain specific behavior of target nerve unit, on the other hand again can be by the activity of this neuron through intelligence
Control device be processed as shock parameters, in turn from the time and spatially control shock by electricity precision.
Animal behavior supervising device 103 includes video camera 109, video frequency collection card 110, behavior analysis software 111, by taking the photograph
Camera 109 shoots animal active situation in electric shock experimental box, is connected to divide equipped with behavior by video with video frequency collection card 110
In the computer of analysis software 111, it is achieved for monitoring and the behavior analysis in real time of animal behavior, behavior analysis software 111 is permissible
By the specific action of animal, the information such as duration and action time of origin, space obtains the number of Animal Behavior Science
According to, analysis the data obtained is transferred to intelligent controlling device by output lead by supervising device.
Electric shock controls device 104 and is made up of power supply 112, foot shock plate 113, signal input line 114, wire 115.Signal
Input line 114 receives the signal from intelligent controlling device, and this signal can switch with code power, voltage amplitude.Foot shock
Plate 113 is combined by circuit board and conducting metal rod.Power supply 112 is formed by a series of battery combination, and each set of cells can
Individually to supply electricity to corresponding wire 115, and wire is by the corresponding each conducting metal rod of foot shock plate, it is achieved accurate
Particular space gives electricity.Electric potential difference is formed, then have only to conductor and just can form electric current between specific two metal bars.Therefore
When mice is movable in behavior experimental box body 105, just can form path conduction when extremity are stepped on conducting metal rod, thus connect
Receive the electric shock of specific site.
In this specific embodiment, multi-channel signal acquiring is utilized to analyze software 108 (the most special animal physiological index
Inspection software) and behavior analysis software 111 (the most special Animal Behavior Science analyzes software) read out the physical signs of animal, the heart
Reason activity and behavior state, intelligent controlling device carries out scoring accordingly and obtains corresponding data message, adding of these data messages
Weight average obtains a new scoring, and this scoring is electrically shocked control device and extracts, by electricity in various degree in these information correspondences
(scoring such as freezing reaction is 5 points to hit intensity, and in physical signs, the scoring of epinephrine haemoconcentration is 5 points, after carrying out weight
The final scoring obtained is 6 points, and the size of current that correspond to 0.6mA shocks by electricity), and the behavior state of animal is divided by behavior
Analysis software 111 can obtain the positional information of animal, and this positional information can control the site of electric shock (in the middle of such as with electric-shocking plate
As initial point, the positional information of mice can be expressed as (x, y), this positional information be electrically shocked control device extract thus
(x, y) place shocks by electricity), therefore can carry out real-time implementation specific site certain strength by the behavior of animal and physical signs
Electric shock.
In the specific embodiment that Fig. 7 provides for the present invention, electric shock controls the connection diagram of device, as shown in Figure 7, its with
How mice carries out precise time and space foot shock as object description.Such as Fig. 7, many animals are at behavioristics's experimental box
Freely activity in body, is obtained physiology and the behavior state of mice, then physiology and behavior signal is inputted by bio-feedback arrangement
To intelligent controlling device, intelligent controlling device judges that the forelimb of this mice needs to receive foot shock, then will need electric shock
Signal passes through, with or without input to power supply, power supply, two metal bars that circuit board is stepped on for mice forelimb with voltage amplitude, voltage
Apply voltage, then produce electric current at mice forelimb and reach the effect of electric shock.
The circuit board of selectivity electric shock and the combination signal of conducting metal rod in the specific embodiment that Fig. 8 provides for the present invention
Figure, as shown in Figure 8, welds the brill button of conducting metal rod and circuit board, and this circuit board is so that any two is adjacent
Between conducting metal rod produce electric potential difference thus any two adjacent conducting metal rods and can be carried out electric shock.And mice
The size of the sole of extremity just can cover adjacent two metal bar, and the range shorter of the electric shock that therefore can produce is to little
The size of sole before and after Mus.
The key point of the present invention with being intended to protect is a little:
1, several contents that intelligent foot shock device based on biofeedback includes: intelligent controlling device, behavior school superintendent
Control device, bio-feedback arrangement and electric shock control device
2, intelligent controlling device is for passing through machine word from the signal of behavioristics's supervising device and bio-feedback arrangement
Speech carries out the process that encodes, and the Signal coding mistake controlled when the signal of device inputs for shock parameters that shock by electricity for downstream
Journey.
3, electric shock controls device, including the combination of design, power supply and the signal input line of independent current source so that ad-hoc location
Electric shock be possibly realized.
4, the preparation of foot shock plate, including circuit board and the combination of conducting metal rod, and and shocks by electricity in control device
The connection of miscellaneous part.
5, the circuit design of circuit board, makes adjacent two metal bars can obtain electric potential difference, thus gives laboratory animal essence
True little scope foot shock.
6, bio-feedback arrangement and behavioristics's supervising device are for animal physiological information and the acquisition of behavioristics's information, and
Both hierarchical informations are carried out the analytical equipment integrated.
The beneficial effects of the present invention is:
First is by adding a set of bio-feedback arrangement, behavior and the physical signs of animal being converted into machine word
Speech, through the signal analysis of intelligent controlling device, can give animal for specific behavior reaction and physiological status real-time
Foot shock.Second is to export stimulation instructions by intellectual analysis device, and this instruction can be by the intensity of electric shock, time, space
Signal through electric shock control device realize voltage size, with or without and voltage selectivity output big mice is carried out accurately
Intensity, time, the foot stimulating in space；3rd is that the design of circuit board makes the local electric shock of little scope be possibly realized, thus
The scope of more precise control electric shock.More than based on, this device can enter for the different behavior reactions of animal and physiological reaction
Real-time and the intelligent foot shock of row, thus probe into animal more delicately for the avoidance of this malignant event that shocks by electricity and memory machine
System.
One of ordinary skill in the art will appreciate that all or part of flow process realizing in above-described embodiment method, Ke Yitong
Crossing computer program and complete to instruct relevant hardware, described program can be stored in general computer read/write memory medium
In, this program is upon execution, it may include such as the flow process of the embodiment of above-mentioned each method.Wherein, described storage medium can be magnetic
Dish, CD, read-only store-memory body (Read-Only Memory, ROM) or random store-memory body (Random Access
Memory, RAM) etc..
Those skilled in the art are it will also be appreciated that various functions that the embodiment of the present invention is listed are by hardware or soft
Part realizes depending on specifically applying the design requirement with whole system.Those skilled in the art can be specific for every kind
Application, it is possible to use the function described in the realization of various methods, but this realization is understood not to protect beyond the embodiment of the present invention
The scope protected.
The present invention applies specific embodiment principle and the embodiment of the present invention are set forth, above example
Explanation be only intended to help to understand method and the core concept thereof of the present invention；Simultaneously for one of ordinary skill in the art,
According to the thought of the present invention, the most all will change, in sum, in this specification
Hold and should not be construed as limitation of the present invention.
Claims (11)
1. an intelligent foot shock system based on biofeedback, is characterized in that, described system include intelligent controlling device,
Bio-feedback arrangement, electric shock control device and animal behavior supervising device,
Wherein, described bio-feedback arrangement, for gathering physiological activity information and the mental activity information of animal, described life
Reason action message includes that heartbeat data, described mental activity information include activity data；
Described animal behavior supervising device, for gathering the behavior signal of animal, analyzes and obtains behavioristics's data；
Described intelligent controlling device, for according to described physiological activity information, mental activity information and behavioristics's data
Generate electric shock instruction；
Described electric shock controls device, for shocking by electricity animal according to described electric shock instruction.
System the most according to claim 1, is characterized in that, described bio-feedback arrangement includes heart rate survey meter, electrode
And Multi-channel signal analysis module,
Wherein, described heart rate survey meter, for reading the heartbeat data of animal；
It is implanted to the electrode of target area in the brain of animal, for recording the activity data of animal nerve unit；
Described Multi-channel signal analysis module, for the heartbeat data described in collection integration and activity data, and by institute
The heartbeat data stated and active data transmission are to described intelligent controlling device.
System the most according to claim 2, is characterized in that, described animal behavior supervising device includes video camera, video
Capture card and behavior analysis module,
Wherein, described video camera, for shooting animal behavior signal in electric shock experimental box, described behavior signal includes
Specific action, duration, action time of origin and spatial information, and by described behavior signal by described regarding
Frequently capture card transmission is to described behavior analysis module；
Described behavior analysis module, obtains behavioristics's data for analyzing described behavior signal, and by described behavioristics
Data transmission is to described intelligent controlling device.
System the most according to claim 3, is characterized in that, described intelligent controlling device includes:
First acquisition module, for obtaining physiological activity information and the mental activity information of animal；
Second acquisition module, for obtaining behavioristics's data of animal；
Coding module, for described behavioristics's data are encoded, the behavioristics's data after being encoded；
Electric shock directive generation module, the behavior after analyzing described physiological activity information, mental activity information and coding
Learn data, generate electric shock instruction.
System the most according to claim 4, is characterized in that, described electric shock controls device and includes and described Based Intelligent Control
The wire that the power supply that the signal input line that device is connected is connected with described signal input line is connected with described power supply with
And the foot shock plate being connected with described wire.
System the most according to claim 5, is characterized in that, described foot shock plate includes circuit board and a plurality of conduction
Stainless steel strip, described conduction stainless steel strip is arranged side by side.
System the most according to claim 6, is characterized in that, described wire is a plurality of.
System the most according to claim 7, is characterized in that, the number phase of described conduction stainless steel strip and described wire
With, and connect one to one.
System the most according to claim 6, is characterized in that, is spaced apart 2.5 millimeters between described conduction stainless steel strip.
System the most according to claim 6, is characterized in that, described conduction stainless steel strip is 16.
11. systems according to claim 10, is characterized in that, described conduction a diameter of 6 millimeters of stainless steel strip, length
It it is 180 millimeters.
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