CN106110404A - The manufacture method of catheter - Google Patents
The manufacture method of catheter Download PDFInfo
- Publication number
- CN106110404A CN106110404A CN201610652367.0A CN201610652367A CN106110404A CN 106110404 A CN106110404 A CN 106110404A CN 201610652367 A CN201610652367 A CN 201610652367A CN 106110404 A CN106110404 A CN 106110404A
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- CN
- China
- Prior art keywords
- catheter
- manufacture method
- immersed
- dissolved
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses the manufacture method of a kind of catheter, belong to medical material tech field, including herein below: a. acetone and ethanol are pressed 1:1 and formed solvent, take PLGA and are dissolved in described solvent;B. adding nitrofural, mixing is dissolved, centrifugal after take supernatant to container, catheter is immersed in container in supernatant, uniformly pulls out, put in drying baker and be dried until solvent volatilizees completely under room temperature;It is immersed in 15min in the hydrogen peroxide liquid that concentration is 3% the most again.Prevention short-term indwelling catheter infects, with low cost, and manufacture method is simple, and Production Time is short.
Description
Technical field
The present invention relates to medical material tech field, in particular to the manufacture method of a kind of catheter.
Background technology
Catheter is mainly used in clinical apoplexy, fracture and critically ill patient and is detained urethral catheterization, is medical treatment most-often used in hospital
One of apparatus, the inpatient of about 25% uses catheter between demurrage.In use, due to various factors, often
The urinary tract infection caused along with conduit.Periodically carrying out urethral orifice cleaning and sterilization to stop antibacterial to invade is can to take at present
Prevention method, antibacterial, once enter urethral orifice, protects inefficacy.
Summary of the invention
It is an object of the invention to provide the manufacture method of simple, with low cost, the most antibacterial a kind of catheter, with
Solve the problems referred to above.
For realizing the object of the invention, the technical scheme of employing is: the manufacture method of catheter, including herein below:
A. 1:1 composition solvent pressed by acetone and ethanol, takes Poly(D,L-lactide-co-glycolide and is dissolved in described solvent;
B. adding nitrofural, mixing is dissolved, centrifugal after take supernatant to container, catheter is immersed in container in supernatant,
Uniformly pull-out, puts in drying baker and is dried until solvent volatilizees completely under room temperature;
It is immersed in 15min in the hydrogen peroxide liquid that concentration is 3% the most again.
Further, the dried catheter of step b is dipped to by ketopyrrolidine, dehydrated alcohol, polyurethanes again
In the coating solution of composition;Oven for drying it is taken out to after immersion.
Further, after step c, conduit takes out from hydrogen peroxide liquid, extracts sterile physiological with disposable syringe
Saline 20mL respectively rinses 10mL along inside and outside tube wall.
The invention has the beneficial effects as follows, with Poly(D,L-lactide-co-glycolide as carrier, nitrofural is antibiotic substance,
The novel urinary catheter using dip-coating czochralski method development achieves sustained drug release effect, is used for preventing short-term indwelling catheter to infect, cost
Cheap, manufacture method is simple, and Production Time is short.
Detailed description of the invention
Below by specific embodiment, the present invention is described in further detail.
The manufacture method of the catheter that the present invention provides, including herein below:
A. 1:1 composition solvent pressed by acetone and ethanol, takes Poly(D,L-lactide-co-glycolide and is dissolved in described solvent;
B. adding nitrofural, mixing is dissolved, centrifugal after take supernatant to container, catheter is immersed in container in supernatant,
Uniformly pull-out, puts in drying baker and is dried until solvent volatilizees completely under room temperature, centrifugal rotational speed 3000r/min;
It is immersed in 15min in the hydrogen peroxide liquid that concentration is 3% the most again.
Hydrogen peroxide has killing action to bacterial propagule, virus, fungus, reduces the clump count in conduit.After sterilization
Conduit takes out from hydrogen peroxide liquid, preferably respectively rinses along inside and outside tube wall with disposable syringe extraction physiological saline solution 20mL
10mL, to reduce the stimulation to skin mucosa.
Conduit needs before immersing supernatant to clean.The dried catheter of step b is dipped to by ketopyrrolidine, anhydrous second again
In the coating solution of alcohol, polyurethanes composition;It is taken out to oven for drying after immersion, enough makes the catheter produced possess super
The effect of lubrication, so easy and convenient when inserting catheter, to alleviate patient painful.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for the skill of this area
For art personnel, can there be various modifications and variations in the spirit and principles in the present invention, the modification of these equivalents or replacement etc.,
Within being all contained in protection scope of the present invention.
Claims (3)
1. the manufacture method of catheter, it is characterised in that include herein below:
A. 1:1 composition solvent pressed by acetone and ethanol, takes Poly(D,L-lactide-co-glycolide and is dissolved in described solvent;
B. adding nitrofural, mixing is dissolved, centrifugal after take supernatant to container, catheter is immersed in container in supernatant,
Uniformly pull-out, puts in drying baker and is dried until solvent volatilizees completely under room temperature;
It is immersed in 15min in the hydrogen peroxide liquid that concentration is 3% the most again.
The manufacture method of catheter the most according to claim 1, it is characterised in that the dried catheter of step b soaks again
In the coating solution that bubble is extremely made up of ketopyrrolidine, dehydrated alcohol, polyurethanes;Oven for drying it is taken out to after immersion.
The manufacture method of catheter the most according to claim 2, it is characterised in that after step c, conduit is from hydrogen peroxide
Liquid takes out, respectively rinses 10mL with disposable syringe extraction physiological saline solution 20mL along inside and outside tube wall.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610652367.0A CN106110404A (en) | 2016-08-11 | 2016-08-11 | The manufacture method of catheter |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610652367.0A CN106110404A (en) | 2016-08-11 | 2016-08-11 | The manufacture method of catheter |
Publications (1)
Publication Number | Publication Date |
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CN106110404A true CN106110404A (en) | 2016-11-16 |
Family
ID=57257659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610652367.0A Pending CN106110404A (en) | 2016-08-11 | 2016-08-11 | The manufacture method of catheter |
Country Status (1)
Country | Link |
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CN (1) | CN106110404A (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101199872A (en) * | 2006-12-14 | 2008-06-18 | 天津市凯迪亚医疗器械有限公司 | Double medicament controlled-release coating micropore ACS bracket |
CN201431691Y (en) * | 2009-07-08 | 2010-03-31 | 大连理工大学 | Catheter with antimicrobial and hydrophilic coatings |
CN104771789A (en) * | 2014-08-26 | 2015-07-15 | 江苏坤宇集团有限公司 | Antibacterial medical conduit and preparation method thereof |
CN105597217A (en) * | 2016-02-29 | 2016-05-25 | 浙江曙光科技有限公司 | PVC ultra-smooth hydrophilic catheter and preparation method thereof |
-
2016
- 2016-08-11 CN CN201610652367.0A patent/CN106110404A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101199872A (en) * | 2006-12-14 | 2008-06-18 | 天津市凯迪亚医疗器械有限公司 | Double medicament controlled-release coating micropore ACS bracket |
CN201431691Y (en) * | 2009-07-08 | 2010-03-31 | 大连理工大学 | Catheter with antimicrobial and hydrophilic coatings |
CN104771789A (en) * | 2014-08-26 | 2015-07-15 | 江苏坤宇集团有限公司 | Antibacterial medical conduit and preparation method thereof |
CN105597217A (en) * | 2016-02-29 | 2016-05-25 | 浙江曙光科技有限公司 | PVC ultra-smooth hydrophilic catheter and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
朱元元: "呋喃西林涂层尿管的制作方法及药物缓释效果研究", 《中华医院感染学杂志》 * |
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C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161116 |
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RJ01 | Rejection of invention patent application after publication |