CN105963565A - Feed additive for preventing and treating colibacillosis in minks and preparation method thereof - Google Patents
Feed additive for preventing and treating colibacillosis in minks and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a feed additive for preventing and treating colibacillosis in minks. The prepared feed additive is made from the materials: Rubus corchorifolius leaf, tortoise meat, polished round-grained rice, figs, Cymbopogon citratus, Patrinia scabiosaefolia, Rhizoma Polygoni Cuspidati, Fructus Forsythiae, garlic, hawthorn fruit, Chinese cabbage, Herba Portulacae, Semen Plantaginis, Pleurotus ostreatus, fennel and Radix Glycyrrhizae Preparata. The feed additive is made from natural Chinese herbs and food materials, is safe and free of toxic and side effect and can treat colibacillosis in minks quickly and effectively, the feed additive is added directly into feed and easily consumed by minks, can treat colibacillosis according to its causes and can provide the minks with physically required vitamins, minerals and the other nutrients, enhancing physique of the minks, improving immunity, promoting their recovery, relieving the impact of colibacillosis upon growth and development of the minks, lowering mortality, and ensuring utilization for farmers.
Description
Technical field
The present invention relates to a kind of feed additive preventing and treating mink colibacillosis and preparation method thereof.
Background technology
Mink is a kind of half aquatic animals, is good at swimming, diving, prefers summer to play in the water.Mink leather and fur
Belonging to thin fur fur coat, dermatotome is excellent, the most solid, and lint is abundant, bright in luster, mainly originates in U.S.
Continent and European Region.The leather and fur clothing made with it, elegant and poised, it is preferable fur products, has " fur coat
In king " laudatory title, become the most again the symbol that people are rich and honour.Abroad, " soft gold " it is referred to as.
Fur has the San great Te of " wind fur Mao Gengnuan, the snow fur snow that falls is from disappearing, and the rain fur hair that falls is the wettest "
Point, has the highest economic worth.Mink colibacillosis is a kind of acute infectious disease, is by escherichia coli
Cause.The escherichia coli that primary disease mostly is in spontaneous infection, i.e. intestinal are when mink Abwehrkraft des Koepers declines
Can breed rapidly, produce virulence, cause and cause a disease.This disease at the initial stage of a disease more shows as loss of appetite, essence
God is the best, and body temperature raises, and asoscope is dried, and loose and watery stool is soft in yellow or Lycoperdon polymorphum Vitt, dysentery, water then occurs
Sample diarrhoea and hemafecia, myasthenia of limbs, have a delicate constitution, and the back of a bow of bending over, perianal fecal pollution is serious.
Mink especially children's ermine food intake undernutrition, health is not good enough, it is easy to suffer from this sick.Use traditional
Oral, the method for injection of antibiotics prevents and treats this disease, although can play certain effect, but easily cause
Stronger Drug resistance, and infringement mink autoimmunity, affect its normal growth and grow.
Summary of the invention
It is an object of the invention to provide a kind of feed additive preventing and treating mink colibacillosis and preparation thereof
Method.This feed additive uses natural Chinese medicinal herb and food materials to make, and safe without toxic side effect can be fast
Speed effectively treatment mink colibacillosis, product is added directly in feedstuff and facilitates mink to search for food, for
While this disease of cause of disease treatment for diseases, can the nutrition such as vitamin, mineral needed for supplementary children's ermine health
Material, strengthens its body constitution, improves autoimmunity, promotes mink rehabilitation, alleviates this disease normal to ermine
The impact of growth promoter, reduces mortality rate, ensures the utilization of raiser.
To achieve these goals, the technical scheme that the present invention provides is as follows:
A kind of feed additive preventing and treating mink colibacillosis, makes the raw material group of described feed additive
Become and parts by weight are: Fructus Hordei Vulgaris bubble leaf 3-5 part, Carnis Testudinis 10-15 part, Semen oryzae sativae 20-30 part, Fructus Fici
8-12 part, Herba Cymbopogonis Citrari 7-12 part, Patrinia scabiosaefolia Fisch grass 8-12 part, Rhizoma Polygoni Cuspidati 5-7 part, Fructus Forsythiae 9-13 part, greatly
Bulbus Allii 8-12 part, Fructus Crataegi 9-13 part, Chinese cabbage 15-20 part, Herba Portulacae 15-20 part, Semen Plantaginis 6-10 part,
Pleurotus ostreatus 7-10 part, Caulis et Folium Foeniculi 8-12 part, Radix Glycyrrhizae Preparata 3-5 part.
Further, make described feed additive raw material composition and parts by weight be: Fructus Hordei Vulgaris bubble leaf 3
Part, Carnis Testudinis 10 parts, Semen oryzae sativae 20 parts, Fructus Fici 8 parts, 7 parts of Herba Cymbopogonis Citrari, Patrinia scabiosaefolia Fisch grass 8 parts, tiger
Cane 5 parts, Fructus Forsythiae 9 parts, 8 parts of Bulbus Allii, Fructus Crataegi 9 parts, Chinese cabbage 15 parts, Herba Portulacae 15 parts, Herba Plantaginis
Son 6 parts, Pleurotus ostreatus 7 parts, Caulis et Folium Foeniculi 8 parts, Radix Glycyrrhizae Preparata 3 parts.
Further, make described feed additive raw material composition and parts by weight be: Fructus Hordei Vulgaris bubble leaf 5
Part, Carnis Testudinis 15 parts, Semen oryzae sativae 30 parts, Fructus Fici 12 parts, 12 parts of Herba Cymbopogonis Citrari, Patrinia scabiosaefolia Fisch grass 12 parts,
Rhizoma Polygoni Cuspidati 7 parts, Fructus Forsythiae 13 parts, 12 parts of Bulbus Allii, Fructus Crataegi 13 parts, Chinese cabbage 20 parts, Herba Portulacae 20 parts,
Semen Plantaginis 10 parts, Pleurotus ostreatus 10 parts, Caulis et Folium Foeniculi 12 parts, Radix Glycyrrhizae Preparata 5 parts.
Further, make described feed additive raw material composition and parts by weight be: Fructus Hordei Vulgaris bubble leaf 4
Part, Carnis Testudinis 12 parts, Semen oryzae sativae 25 parts, Fructus Fici 10 parts, 10 parts of Herba Cymbopogonis Citrari, Patrinia scabiosaefolia Fisch grass 10 parts,
Rhizoma Polygoni Cuspidati 6 parts, Fructus Forsythiae 11 parts, 10 parts of Bulbus Allii, Fructus Crataegi 11 parts, Chinese cabbage 17 parts, Herba Portulacae 17 parts,
Semen Plantaginis 8 parts, Pleurotus ostreatus 8 parts, Caulis et Folium Foeniculi 10 parts, Radix Glycyrrhizae Preparata 4 parts.
Mink colibacillosis is a kind of acute infectious disease, escherichia coli cause.Primary disease mostly is certainly
Send out and infect, i.e. escherichia coli in intestinal can breed rapidly when mink Abwehrkraft des Koepers declines, and produces poison
Power, causes and causes a disease.If mink food intake undernutrition, then body constitution is more weak, and resistance is poor, holds very much
Being susceptible to suffer from colibacillosis, serious even can cause children ermine dead.Antibiotics is used to treat this disease,
Not only can cause Drug resistance, and infringement children's ermine autoimmunity, rear mink is more easy to sense various infection disease
Disease, is unfavorable for mink healthy growth and development, and inventor thinks that the emphasis preventing and treating this disease is the most simply limited to
Suit the remedy to the case according to disease and treat this disease, also reside in enhancing mink body constitution, improve himself immunity, with
Strengthen its resistance against diseases.Therefore, the raw material selected by the feed additive of the present invention has the feature that
Fructus Hordei Vulgaris bubble leaf: puckery, temperature, have help digestion long-pending, antidiarrheal dysentery, removing toxic substances, invigorate blood circulation, regulating menstruation, the merit such as hemostasis
Effect, cures mainly food stagnation glutted, and belly pain is suffered from diarrhoea, red-white dysentery, and under red metrorrhagia and leukorrhagia, traumatic injury is controlled in external, yellow
Chickenpox；
Carnis Testudinis: nutritive value is higher, containing protein, animal glue, fat, saccharide and calcium, phosphorus, ferrum and
The nutritional labelings such as multivitamin, and be readily absorbed by, nature and flavor are sweet, sour, warm, enter liver, lung, kidney channel,
Can be used for pulmonary tuberculosis, cough, spit blood, spit blood, dysentery, polyuria, the enuresis, hemorrhoidal hamorrhage, bones and muscles pain,
The disease such as uterine prolapse, diabetes；
Semen oryzae sativae: containing rich in protein, the aminoacid of contained needed by human is also the most comprehensive, possibly together with
The multiple nutritional components such as fat, calcium phosphorus, ferrum and vitamin B group, Semen oryzae sativae only has YIN nourishing and the production of body fluid promoting, relieving restlessness
Yearningly, strengthening the spleen and stomach, invigorating middle warmer gas, effect of intestine-stabling and anti-diarrheal；
Fructus Fici: nutritious and comprehensive, except containing several amino acids, quininic acid, lipase, albumen
The Multiple components such as enzyme, have good dietetic therapy effect, Fructus Fici contain malic acid, citric acid, lipase,
Protease, hydrolytic enzyme etc., can help the human body digestion to food, promotes appetite, contains multiple because of it again
Lipid, therefore there is the effect of loosening bowel to relieve constipation.Contained lipase, hydrolytic enzyme etc. have reduction blood fat and decomposition
The function of blood fat, can reduce fatty in endovascular deposition, and then play blood pressure lowering, prevent coronary heart disease
Effect.Fructus Fici has the merit of anti-inflammation detumescence, can relieving sore throat and diminishing swelling, the fruit juice of its mature fruit can extract one
Planting aromatic substance " benzaldehyde ", both of which has cancer-resisting, the effect of enhancing body resistance against diseases,
The generation of kinds cancer can be prevented, delay the development of transplantability adenocarcinoma, lymphosarcoma, promote it to degenerate,
And normal cell will not be produced murder by poisoning, Fructus Fici has invigorating the stomach and promoting bowel movement, the effect of subduing swelling and detoxicating, can control intestinal
Inflammation, dysentery, constipation, hemorrhoid, laryngalgia, ulcerative carbuncle scabies, throat, anthelmintic of whetting the appetite, for appetite not
Shake, abdominal distention, constipation due to hemorrhoids, dyspepsia, hemorrhoid, proctoptosis, diarrhoea, hypogalactia, throat
Swell and ache, hematodiarrhoea, the disease such as cough ant phlegm；
Herba Cymbopogonis Citrari: pungent, temperature, expelling wind and removing dampness, reducing swelling and alleviating pain, for rheumatalgia, headache, stomachache, abdomen
Bitterly, diarrhoea, menoxenia, puerperal edema, traumatic injury congestion swells and ache；
Patrinia scabiosaefolia Fisch grass: heat-clearing and toxic substances removing, removing heat from blood, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing, for acute appendicitis, lung abscess
High heat, coughs vomiting bloody pus, pyretic toxicity skin ulcer furuncle, and furuncle pain is swollen, chest and abdomen pain, appendicitis, enteritis, dysentery,
Puerperal abdonimal pain, dysmenorrhea, Herba Patriniae has antiviral, antitumor, function of gallbladder promoting, diuresis, stimulated hepatic cell regeneration etc.
Effect, Herba Patriniae has certain antibacterial action, and induced by endotoxin has obvious Attenuation, and Patrinia scabiosaefolia Fisch has
Significantly calm, syngignoscism, stronger than the tranquilizer Rhizoma et radix valerianae of western classical more than one times, it is calm, urge
The effective ingredient of dormancy effect is mainly volatile oil, patrinene, isopatrinene, patrinoside also have calmness,
Syngignoscism, Patrinia scabiosaefolia Fisch has significant leukocyte increasing and strengthens the phagocytosis of macrophage；
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, there is dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, cough-relieving
Effect of expectorant, for jaundice due to damp-heat, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, burn due to hot liquid or fire,
Amenorrhea, lump in the abdomen, instep plays damage, cough due to lung-heat, Rhizoma Polygoni Cuspidati decocting liquid to staphylococcus aureus, micrococcus catarrhalis,
A type or group B streptococcus, escherichia coli, bacillus pyocyaneus have inhibitory action；
Fructus Forsythiae: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens, modern medicine study confirms, Fructus Forsythiae concentrates
Decoct has antibacterial action in vitro, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bar
Bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.；
Bulbus Allii: temperature, stomach invigorating in acrid, sweet, warm, helps digestion and regulates the flow of vital energy, and detoxify parasite killing, reducing swelling and alleviating pain, antidiarrheal
Dysentery relieving, controls lung, anthelmintic, also warming the spleen warming the stomach, controls swollen ulcer drug, white bald tinea skin ulcer, and dysentery is had loose bowels,
Pulmonary tuberculosis pertussis, ascarid pinworm, eating accumulation, coldness and pain in the epigastrium, edema distension, sulfur-containing compound in Bulbus Allii
There is strong antibacterial and anti-inflammation functions, multiple coccus, bacillus, fungus and virus etc. are all had suppression and kills
The effect of going out, is the one that in the current natural plants found, antibacterial action is the strongest, the garlicin contained by Bulbus Allii
Combine with vitamin B1, the effect that can well play allaying tiredness, regain one's strength；
Fructus Crataegi: Fructus Crataegi containing abundant vitamin, Crataegolic acid, citric acid, flavonoid etc., can promoting the production of body fluid to quench thirst,
Also can be used as medicine, acid is sweet, tepor, promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, and meat stagnation controlled by expelling tenia, abdominal mass,
Phlegm retention, acid regurgitation, hemorrhoidal hamorrhage, lumbago, lochiorrhea, the food stagnation of children's's breast, stomach alkane distension, dysentery stomachache,
Blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipidemia, Fructus Crataegi to dysentery bacterium,
Escherichia coli, Bacillus proteus, Bacillus typhi, bacillus pyocyaneus etc. have antibacterial action；
Chinese cabbage: cold nature, has clearing heat and relieving fidgetness, diuresis of quenching one's thirst, tonneau the intestines and stomach, the effect of clearing away lung-heat, Chinese cabbage
Nutritious, except containing saccharide, fat, protein, crude fibre, calcium, phosphorus, ferrum, carotene, sulfur
Outside amine element, nicotinic acid, still containing abundant vitamin, such as vitamin C, vitamin A, vitamin B1, dimension
Raw element B2, vitamin E etc., wherein vitamin C, the body resistance to infecting can be increased；
Herba Portulacae: cold in nature, sweet in the mouth acid, enter the heart, liver, spleen, large intestine channel, have that removing dampness is antipruritic, heat clearing away
Detumescence, heat-clearing and toxic substances removing, diuretic dries, and dissipates blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, and stop blooding removing heat from blood
Effect, Herba Portulacae has stronger inhibitory action to dysentery bacterium, Bacillus typhi and escherichia coli, can be used for
The auxiliary treatment of various inflammation, have the title of " natural antibiotics ", and Herba Portulacae is also rich in vitamin C simultaneously,
Vitamin C has good antioxidation can be with whitening nourishes rough skin, and modern medicine finds, Herba Portulacae
There are higher nutritive value and medical value, except containing conventional proteins,vitamins,and minerals etc.
Outside nutrient, Herba Portulacae is possibly together with unique bioactive ingredients, it is possible to strengthen Human Epithelial Cells
Activity, help lend some impetus to ulcer and healing；
Semen Plantaginis: sweet, cold, diuretic, heat clearing away, improving eyesight, eliminate the phlegm, control urinary obstruction, stranguria with turbid discharge, leukorrhagia,
Hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion hides from view, and Semen Plantaginis mucus Han volume, in mucus
Containing acidic mucopolysaccharide plantasan, vitamin A, B1；
Pleurotus ostreatus: warm in nature, sweet in the mouth, has effect of wind dispelling cold expelling, relaxing muscles and tendons and activating QI and blood in the collateral, be used for controlling lumbago and skelalgia,
The diseases such as numb hand and foot, grain are obstructed, cancerous cell is had the strongest suppression to make by the proteoglycan body in Pleurotus ostreatus
With, Pleurotus ostreatus also has substantial amounts of mushroom ribonic acid, it is possible to the effectively synthesis of suppression antibacterial and breeding, Pleurotus ostreatus simultaneously
In nutritional labeling can also enhance metabolism, health invigorating, enhancing immunity, Pleurotus ostreatus contain multiple protein
Matter, aminoacid, these aminoacid can stimulate taste organ to produce the sensation of delicate flavour, play food calling effect,
Pleurotus ostreatus is rich in vitamin B complex and vitamin C；
Caulis et Folium Foeniculi: acrid in the mouth, warm in nature, stimulating appetite, cold expelling of regulating the flow of vital energy, there is supporing yang road, containing abundant dimension
Raw element B1, B2, C, PP, carotene and cellulose, cause that it has the pungent abnormal smells from the patient of special perfume (or spice) is
Oleum Anisi Stellati, can have, with the neural blood vessel of stimulating intestine and stomach, effect that stomach invigorating is regulated the flow of vital energy, and methoxybenzene is in Fructus Foeniculi
Very active a kind of composition, escherichia coli, dysentery bacterium and Bacillus proteus etc. are had and well press down by it
Make use, can prevent, treat multi-infection diarrhoea；
Radix Glycyrrhizae Preparata: containing multiple chemical compositions such as glycyrrhizin, enoxolone, Angelica Polysaccharide, have anti-
Inflammation and anti-allergy action, scalable body's immunity, antitumor and analgesic effect, therefore process sweet
The primary efficacy of grass is and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.
This feed additive using natural Chinese medicinal herb and food materials as raw material, formula safe without toxic side effect, former
In material, Fructus Hordei Vulgaris bubble leaf, Fructus Fici, Patrinia scabiosaefolia Fisch grass, Rhizoma Polygoni Cuspidati, Fructus Forsythiae, Chinese cabbage, Herba Portulacae, Herba Plantaginis
Son share the effect of heat-clearing and toxic substances removing, and in purged body, hot and humid ecchymosis effectively regulates body；Patrinia scabiosaefolia Fisch is careless, brave
Cane, Fructus Forsythiae, Bulbus Allii, Fructus Crataegi, Herba Portulacae, Pleurotus ostreatus, Caulis et Folium Foeniculi share and can play the most antibacterial pressing down
Bacterium antiinflammation, can effectively kill pathogenic bacterium, prevent and treat this disease；Fructus Hordei Vulgaris bubble leaf, Carnis Testudinis, Semen oryzae sativae, nothing flower
Really, Herba Cymbopogonis Citrari, Patrinia scabiosaefolia Fisch grass, Bulbus Allii, Fructus Crataegi share and can effectively alleviate dysentery symptom, alleviate and suffer from ermine
Painful；Patrinia scabiosaefolia Fisch grass, Chinese cabbage, Herba Portulacae, Semen Plantaginis share the effect that can play toxin expelling diuresis,
Can effectively help renal metabolism, promote that toxin is discharged, alleviate kidney burden, harmful in promoting mink body
The discharge of material, accelerates mink rehabilitation；Radix Glycyrrhizae Preparata can not only play the effect of anti-inflammation, it is also possible to
Play coordinating the actions of various ingredients in a prescription, promote the effect of drug effect.Selected material combination is proper, safe without toxic side effect, no
Can develop immunity to drugs, each raw material synergism, there is heat-clearing and toxic substances removing, anti-inflammation, antidiarrheal dysentery, toxin expelling
Effect of diuresis, can effectively alleviate mink disease, prophylactic treatment colibacillosis.Meanwhile, selected former
Material nutrient enrich, raw material Carnis Testudinis, Semen oryzae sativae, Fructus Fici, Herba Cymbopogonis Citrari, Bulbus Allii, Fructus Crataegi, Chinese cabbage, Herba Portulacae,
Semen Plantaginis, Pleurotus ostreatus, Caulis et Folium Foeniculi are rich in multiple proteins, aminoacid, vitamin, mineral and trace unit
The nutrient substance such as element, can fully supplement and suffer from ermine health desired nutritional, strengthen and suffer from ermine body constitution, improve himself
Immunity, to strengthen its resistance against diseases.Can supplement what mink body lacked by this feed additive edible
Vitamin A can improve the immunity of breathing, digestion etc., and vitimin supplement E can improve the anti-sense of body simultaneously
The ability of dye, it is also possible to vitimin supplement C makes body tissue become tight such that it is able to resist exopathogen and increase
Resistance, the garlicin contained by Bulbus Allii and Semen Plantaginis, Caulis et Folium Foeniculi, Chinese cabbage, Pleurotus ostreatus rich in vitamin
B1 combines, the effect that can well play allaying tiredness, regain one's strength, to strengthen mink body constitution,
Strengthen its resistance, promote physical recovery.Meanwhile, raw material Fructus Crataegi and Fructus Fici have the work of appetite promoting and the spleen strengthening
With, the aminoacid contained by Pleurotus ostreatus can stimulate taste organ to produce the sensation of delicate flavour, can play food calling effect,
These raw material synergism can alleviate the anorexia suffering from ermine, appetite strengthening, accelerates supplementing of nutrition,
Promote its antisecosis, strengthen its immunity, promote to suffer from ermine rehabilitation.
The invention also discloses the preparation method of the feed additive of described preventing and treating mink colibacillosis, bag
Include following steps:
(1) Fructus Hordei Vulgaris bubble leaf, Herba Cymbopogonis Citrari, Patrinia scabiosaefolia Fisch grass, Rhizoma Polygoni Cuspidati, Fructus Forsythiae, Semen Plantaginis, Radix Glycyrrhizae Preparata add
The water soaking of its gross mass multiple 5 times 1 hour, slow fire boiling 1 hour, cross 100 mesh after decoction and filter
Net takes filtrate, again adds the water soaking 1 hour of its gross mass 4 times, and slow fire boiling crossed 100 after 1 hour
Mesh drainage screen takes filtrate, merges twice filtrate, is cooled to room temperature, gained filtrate cryoconcentration (30 DEG C with
Under) to the thick paste that relative density is 1.33 ± 0.02 (30 DEG C)；
(2) after Fructus Fici, Fructus Crataegi, Chinese cabbage, Herba Portulacae, Caulis et Folium Foeniculi are cleaned, vacuum lyophilization gained
200 mesh mixed-powder A pulverized to obtain by solid；
(3) Carnis Testudinis, Semen oryzae sativae, Bulbus Allii, Pleurotus ostreatus clean after cook, Carnis Testudinis, Semen oryzae sativae, Bulbus Allii, Pleurotus ostreatus with
Step (1) gained thick paste mixing after be cooled to room temperature, vacuum lyophilization gained solid pulverize 200
Mesh mixed powder B；
(4) by mixed-powder A and the mixed powder B mixing of step (1) gained of step (2) gained
Uniformly, feed additive is obtained.
The using method of this feed additive: add the feed additive of the present invention in the daily feedstuff of mink
Feeding mink, described feed additive addition in mink feed is 2～3wt%.
The invention have the benefit that provide a kind of feed additive preventing and treating mink colibacillosis and
Its preparation method.This feed additive uses natural Chinese medicinal herb and food materials to make, safe without toxic side effect,
Can be with rapid, effective treatment mink colibacillosis, product is added directly in feedstuff and facilitates mink to search for food,
While for this disease of cause of disease treatment for diseases, can supplementary children ermine health needed for vitamin, mineral
Deng nutrient substance, strengthen its body constitution, improve autoimmunity, promote mink rehabilitation, alleviate this disease right
The impact that ermine normal growth is grown, reduces mortality rate, ensures the utilization of raiser.Specifically:
(1) this feed additive is made using natural Chinese medicinal herb and food materials as raw material, formula safety non-toxic pair
With, in raw material, Fructus Hordei Vulgaris bubble leaf, Fructus Fici, Patrinia scabiosaefolia Fisch grass, Rhizoma Polygoni Cuspidati, Fructus Forsythiae, Chinese cabbage, Herba Portulacae,
Semen Plantaginis share the effect of heat-clearing and toxic substances removing, and in purged body, hot and humid ecchymosis effectively regulates body；Patrinia scabiosaefolia Fisch grass,
Rhizoma Polygoni Cuspidati, Fructus Forsythiae, Bulbus Allii, Fructus Crataegi, Herba Portulacae, Pleurotus ostreatus, Caulis et Folium Foeniculi share can play the most antibacterial
Inhibiting bacteria and diminishing inflammation effect, can effectively kill pathogenic bacterium, prevent and treat this disease；Fructus Hordei Vulgaris bubble leaf, Carnis Testudinis, Semen oryzae sativae, nothing
Flowers and fruits, Herba Cymbopogonis Citrari, Patrinia scabiosaefolia Fisch grass, Bulbus Allii, Fructus Crataegi are share and can effectively alleviate dysentery symptom, alleviate trouble
Ermine is painful；Patrinia scabiosaefolia Fisch grass, Chinese cabbage, Herba Portulacae, Semen Plantaginis share the effect that can play toxin expelling diuresis,
Can effectively help renal metabolism, promote that toxin is discharged, alleviate kidney burden, harmful in promoting mink body
The discharge of material, accelerates mink rehabilitation；Radix Glycyrrhizae Preparata can not only play the effect of anti-inflammation, it is also possible to
Play coordinating the actions of various ingredients in a prescription, promote the effect of drug effect.Selected material combination is proper, safe without toxic side effect, no
Can develop immunity to drugs, each raw material synergism, there is heat-clearing and toxic substances removing, anti-inflammation, antidiarrheal dysentery, toxin expelling
Effect of diuresis, can effectively alleviate mink disease, prophylactic treatment colibacillosis.
(2) selected by, raw material is nutritious, raw material Carnis Testudinis, Semen oryzae sativae, Fructus Fici, Herba Cymbopogonis Citrari, Bulbus Allii, Fructus Crataegi,
Chinese cabbage, Herba Portulacae, Semen Plantaginis, Pleurotus ostreatus, Caulis et Folium Foeniculi rich in multiple proteins, aminoacid, vitamin,
The nutrient substance such as mineral and trace element, can fully supplement and suffer from ermine health desired nutritional, strengthens and suffers from ermine body
Matter, improves himself immunity, to strengthen its resistance against diseases.Can be supplemented by this feed additive edible
The vitamin A that mink body lacks can improve the immunity of breathing, digestion etc., vitimin supplement E simultaneously
Body anti-infective ability can be improved, it is also possible to vitimin supplement C make body tissue become tight thus can
To resist what exopathogen was built up one's resistance to disease, the garlicin contained by Bulbus Allii and Semen Plantaginis, Caulis et Folium Foeniculi, Chinese cabbage, flat
Mushroom rich in vitamin B1 combine, the effect that can well play allaying tiredness, regain one's strength,
To strengthen mink body constitution, strengthen its resistance, promote physical recovery.
(3) this product is added directly in feedstuff and searches for food for mink, compared to general medicine, uses more
Conveniently, and raw material Fructus Crataegi and Fructus Fici have the effect of appetite promoting and the spleen strengthening, and the aminoacid contained by Pleurotus ostreatus can stimulate
Taste organ produces the sensation of delicate flavour, can play food calling effect, and these raw material synergism can alleviate trouble
The anorexia of ermine, appetite strengthening, accelerate supplementing of nutrition, promote its antisecosis, strengthen its immunity
Power, promotes to suffer from ermine rehabilitation.
Detailed description of the invention
According to following embodiment, the present invention be may be better understood.But, those skilled in the art holds
Readily understood, concrete material proportion, process conditions and result thereof described by embodiment are merely to illustrate this
Invention and should be without limitation on the present invention described in detail in claims yet.
Embodiment 1
A kind of feed additive preventing and treating mink colibacillosis, makes the raw material group of described feed additive
Become and parts by weight are: Fructus Hordei Vulgaris 3 parts of leaf of bubble, Carnis Testudinis 10 parts, Semen oryzae sativae 20 parts, Fructus Fici 8 parts is fragrant
7 parts of thatch, Patrinia scabiosaefolia Fisch grass 8 parts, Rhizoma Polygoni Cuspidati 5 parts, Fructus Forsythiae 9 parts, 8 parts of Bulbus Allii, Fructus Crataegi 9 parts, in vain
Dish 15 parts, Herba Portulacae 15 parts, Semen Plantaginis 6 parts, Pleurotus ostreatus 7 parts, Caulis et Folium Foeniculi 8 parts, Radix Glycyrrhizae Preparata 3 parts.
The preparation method of this feed additive, comprises the following steps:
(1) Fructus Hordei Vulgaris bubble leaf, Herba Cymbopogonis Citrari, Patrinia scabiosaefolia Fisch grass, Rhizoma Polygoni Cuspidati, Fructus Forsythiae, Semen Plantaginis, Radix Glycyrrhizae Preparata add
The water soaking of its gross mass multiple 5 times 1 hour, slow fire boiling 1 hour, cross 100 mesh after decoction and filter
Net takes filtrate, again adds the water soaking 1 hour of its gross mass 4 times, and slow fire boiling crossed 100 after 1 hour
Mesh drainage screen takes filtrate, merges twice filtrate, is cooled to room temperature, gained filtrate cryoconcentration (30 DEG C with
Under) to the thick paste that relative density is 1.33 ± 0.02 (30 DEG C)；
(2) after Fructus Fici, Fructus Crataegi, Chinese cabbage, Herba Portulacae, Caulis et Folium Foeniculi are cleaned, vacuum lyophilization gained
200 mesh mixed-powder A pulverized to obtain by solid；
(3) Carnis Testudinis, Semen oryzae sativae, Bulbus Allii, Pleurotus ostreatus clean after cook, Carnis Testudinis, Semen oryzae sativae, Bulbus Allii, Pleurotus ostreatus with
Step (1) gained thick paste mixing after be cooled to room temperature, vacuum lyophilization gained solid pulverize 200
Mesh mixed powder B；
(4) by mixed-powder A and the mixed powder B mixing of step (1) gained of step (2) gained
Uniformly, feed additive is obtained.
Using method: the feed additive adding the present invention in the daily feedstuff of mink feeds mink, described
Feed additive addition in mink feed is 2～3wt%.
Embodiment 2
A kind of feed additive preventing and treating mink colibacillosis, makes the raw material group of described feed additive
Become and parts by weight are: Fructus Hordei Vulgaris 5 parts of leaf of bubble, Carnis Testudinis 15 parts, Semen oryzae sativae 30 parts, Fructus Fici 12 parts is fragrant
12 parts of thatch, Patrinia scabiosaefolia Fisch grass 12 parts, Rhizoma Polygoni Cuspidati 7 parts, Fructus Forsythiae 13 parts, 12 parts of Bulbus Allii, Fructus Crataegi 13 parts,
Chinese cabbage 20 parts, Herba Portulacae 20 parts, Semen Plantaginis 10 parts, Pleurotus ostreatus 10 parts, Caulis et Folium Foeniculi 12 parts, Radix Glycyrrhizae Preparata
5 parts.
The preparation method of the feed additive of embodiment 2 is identical with embodiment 1 with using method.
Embodiment 3
A kind of feed additive preventing and treating mink colibacillosis, makes the raw material group of described feed additive
Become and parts by weight are: Fructus Hordei Vulgaris 4 parts of leaf of bubble, Carnis Testudinis 12 parts, Semen oryzae sativae 25 parts, Fructus Fici 10 parts is fragrant
10 parts of thatch, Patrinia scabiosaefolia Fisch grass 10 parts, Rhizoma Polygoni Cuspidati 6 parts, Fructus Forsythiae 11 parts, 10 parts of Bulbus Allii, Fructus Crataegi 11 parts,
Chinese cabbage 17 parts, Herba Portulacae 17 parts, Semen Plantaginis 8 parts, Pleurotus ostreatus 8 parts, Caulis et Folium Foeniculi 10 parts, Radix Glycyrrhizae Preparata 4
Part.
The preparation method of the feed additive of embodiment 3 is identical with embodiment 1 with using method.
Embodiment 4 bacteriostatic test
1, experimental strain: colon bacillus (ATCC25922)
2, bacterium culture medium: nutrient agar and nutrient broth medium.
3, bacteriostatic experiment divides three experimental grouies and a matched group, and experimental group uses embodiment 1 to 3 respectively
Feed additive leachate, wherein, experimental group A is the leachate of embodiment 1, and experimental group B is real
Executing the leachate of example 2, experimental group C is the leachate of embodiment 3, and matched group uses normal saline.
4, specific experiment step:
(1) preparation of feed additive leachate: each for the feed additive of embodiment 1 to 3 10g is divided
Do not put into and after 50ml distilled water soaks 2 hours, cross 500 mesh screen, respectively obtain 3 kinds of feedstuffs and add
The leachate of agent；
(2) prepared by susceptibility sense sheet: the round scraps of paper of diameter 6mm made by double-round board qualitative filter paper card punch
Putting in the penicillin empty bottle that cleaning is dried, bottleneck is wrapped up with monolayer kraft paper, 121 DEG C of autoclavings 30
Min, then through 100 DEG C of drying, airtight saves backup.The most respectively the scraps of paper are soaked in enforcement
In the feed additive leachate of example 1 to 3 and normal saline after 2h, take out filter paper, dry in the air under room temperature
Drying one-tenth susceptibility sheet is standby, and 5 susceptibility sense sheets prepared by every kind of medicine；
(3) bacterium solution is prepared: colon bacillus is placed in 10ml nutrient broth medium, 37 DEG C of cultivations
18h；Take 0.9% aseptic sodium chloride solution that culture fluid 1ml adds 9ml, use 10 times of incremental dilution methods,
Bacterium solution is diluted to respectively 105～106cfu/ml, standby；
(4) bacterium solution that above-mentioned steps (3) prepares uniformly is inoculated on mannitol sodium chloride agar plate,
The 20 susceptibility sense sheets prepared in step (2) are laid in colon bacillus and connect by left at room temperature 5min
Kind agar plate on, flat board is inverted in incubator 37 DEG C cultivate 24h after, measure each susceptibility sheet
Antibacterial circle diameter (mm), calculate the antibacterial circle diameter meansigma methods of each group, above operation is sterile working.
5, experimental observation is measured:
Observe: represent with "-" without inhibition zone；
Antibacterial circle diameter ＜ 10mm is the most antibacterial, with "+" represent；
Antibacterial circle diameter 10～14mm is that moderate is antibacterial, represents with " ++ "；
Antibacterial circle diameter ＞ 14mm is that height is antibacterial, represents with " +++ "；
| Matched group | Experimental group A | Experimental group B | Experimental group C | |
| Escherichia coli | - | ++ | +++ | +++ |
Test result indicate that, the pathogenic bacterium of mink colibacillosis are had relatively by the feed additive of the present invention
Strong inhibitory action, can play preferable bactericidal, can play the effect preventing and treating this disease.
Embodiment 4 Application Example
Have selected 40 minks suffering from colibacillosis to test, suffer from ermine and show as inappetence, essence
God is the best, and body temperature raises, and asoscope is dried, and loose and watery stool is soft in yellow or Lycoperdon polymorphum Vitt, dysentery, water how much occurs
Sample diarrhoea and hemafecia, perianal excrement.3 experimental grouies and 1 matched group it is divided at random by suffering from ermine,
Experimental group 1 to 3 uses the feed additive of embodiment 1 to 3 respectively, adds in the daily feedstuff of mink
The feed additive of the present invention feeds mink, and described feed additive addition in mink feed is 2.
5wt%, matched group mink feeds chow diet, after feeding 5 days, statistics children's ermine mortality rate, and observation should
The curative effect of feed additive, the standard of curative effect evaluation is as follows:
Recovery from illness: clinical symptom disappearance, searches for food and mental restoration is normal；
Take a turn for the better: clinical symptom relief, appetite and spirit have been recovered；
Invalid: disease is unchanged, or increase the weight of, or children ermine is dead.
Experimental result statistics is as follows:
| Matched group | Test 1 group | Test 2 groups | Test 3 groups | |
| Cure (only) | 0 | 4 | 6 | 7 |
| Take a turn for the better (only) | 0 | 4 | 4 | 3 |
| Invalid (only) | 10 | 2 | 0 | 0 |
| Effective percentage (%) | 0 | 80 | 100 | 100 |
| Mortality rate (%) | 80 | 0 | 0 | 0 |
By above experimental result it can be seen that the feed additive of the present invention can effectively treat mink large intestine
Bacillosis, all suffer from ermine and the most all has no adverse reaction, i.e. this feed addictive prescription is safe and effective.
Embodiment of above only for technology design and the feature of the present invention are described, its object is to allow and is familiar with this
The people of item technology understands present invention and is carried out, and can not limit the scope of the invention with this,
All equivalence changes done according to spirit of the invention or modification, all should contain the protection model in the present invention
In enclosing.
Claims (5)
1. the feed additive preventing and treating mink colibacillosis, it is characterised in that: make described feedstuff and add
Add agent raw material composition and parts by weight be: Fructus Hordei Vulgaris bubble leaf 3-5 part, Carnis Testudinis 10-15 part, Semen oryzae sativae 20-30
Part, Fructus Fici 8-12 part, Herba Cymbopogonis Citrari 7-12 part, Patrinia scabiosaefolia Fisch grass 8-12 part, Rhizoma Polygoni Cuspidati 5-7 part, Fructus Forsythiae 9-13
Part, Bulbus Allii 8-12 part, Fructus Crataegi 9-13 part, Chinese cabbage 15-20 part, Herba Portulacae 15-20 part, Semen Plantaginis 6-10
Part, Pleurotus ostreatus 7-10 part, Caulis et Folium Foeniculi 8-12 part, Radix Glycyrrhizae Preparata 3-5 part.
A kind of feed additive preventing and treating mink colibacillosis the most as claimed in claim 1, its feature exists
In: make described feed additive raw material composition and parts by weight be: Fructus Hordei Vulgaris bubble 3 parts of leaf, Carnis Testudinis 10 parts,
Semen oryzae sativae 20 parts, Fructus Fici 8 parts, 7 parts of Herba Cymbopogonis Citrari, Patrinia scabiosaefolia Fisch grass 8 parts, Rhizoma Polygoni Cuspidati 5 parts, Fructus Forsythiae 9 parts,
8 parts of Bulbus Allii, Fructus Crataegi 9 parts, Chinese cabbage 15 parts, Herba Portulacae 15 parts, Semen Plantaginis 6 parts, Pleurotus ostreatus 7 parts, fennel
8 parts of Herba Coriandri, Radix Glycyrrhizae Preparata 3 parts.
A kind of feed additive preventing and treating mink colibacillosis the most as claimed in claim 1, its feature exists
In: make described feed additive raw material composition and parts by weight be: Fructus Hordei Vulgaris bubble 5 parts of leaf, Carnis Testudinis 15 parts,
Semen oryzae sativae 30 parts, Fructus Fici 12 parts, 12 parts of Herba Cymbopogonis Citrari, Patrinia scabiosaefolia Fisch grass 12 parts, Rhizoma Polygoni Cuspidati 7 parts, Fructus Forsythiae 13
Part, 12 parts of Bulbus Allii, Fructus Crataegi 13 parts, Chinese cabbage 20 parts, Herba Portulacae 20 parts, Semen Plantaginis 10 parts, Pleurotus ostreatus 10
Part, Caulis et Folium Foeniculi 12 parts, Radix Glycyrrhizae Preparata 5 parts.
A kind of feed additive preventing and treating mink colibacillosis the most as claimed in claim 1, its feature exists
In: make described feed additive raw material composition and parts by weight be: Fructus Hordei Vulgaris bubble 4 parts of leaf, Carnis Testudinis 12 parts,
Semen oryzae sativae 25 parts, Fructus Fici 10 parts, 10 parts of Herba Cymbopogonis Citrari, Patrinia scabiosaefolia Fisch grass 10 parts, Rhizoma Polygoni Cuspidati 6 parts, Fructus Forsythiae 11
Part, 10 parts of Bulbus Allii, Fructus Crataegi 11 parts, Chinese cabbage 17 parts, Herba Portulacae 17 parts, Semen Plantaginis 8 parts, Pleurotus ostreatus 8
Part, Caulis et Folium Foeniculi 10 parts, Radix Glycyrrhizae Preparata 4 parts.
5. the preparation of a kind of feed additive preventing and treating mink colibacillosis as described in Claims 1-4
Method, it is characterised in that: comprise the following steps:
(1) Fructus Hordei Vulgaris bubble leaf, Herba Cymbopogonis Citrari, Patrinia scabiosaefolia Fisch grass, Rhizoma Polygoni Cuspidati, Fructus Forsythiae, Semen Plantaginis, Radix Glycyrrhizae Preparata add it
The water soaking that gross mass multiple is 5 times 1 hour, slow fire boiling 1 hour, cross 100 mesh drainage screens after decoction and take
Filtrate, adds the water soaking 1 hour of its gross mass 4 times again, and slow fire boiling crossed 100 mesh mistakes after 1 hour
Filter screen takes filtrate, merges twice filtrate, is cooled to room temperature, and gained filtrate cryoconcentration (less than 30 DEG C) is extremely
Relative density is the thick paste of 1.33 ± 0.02 (30 DEG C)；
(2), after Fructus Fici, Fructus Crataegi, Chinese cabbage, Herba Portulacae, Caulis et Folium Foeniculi are cleaned, vacuum lyophilization gained is solid
Body pulverizes to obtain 200 mesh mixed-powder A；
(3) Carnis Testudinis, Semen oryzae sativae, Bulbus Allii, Pleurotus ostreatus cook after cleaning, Carnis Testudinis, Semen oryzae sativae, Bulbus Allii, Pleurotus ostreatus and step
Suddenly (1) gained thick paste mixing after be cooled to room temperature, vacuum lyophilization gained solid pulverize 200 mesh mix
Close powder B；
(4) by equal to the mixed-powder A of step (2) gained and the mixed powder B mixing of step (1) gained
Even, obtain feed additive.
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Cited By (1)
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| CN106819622A (en) * | 2016-12-15 | 2017-06-13 | 新昌县柏克动物饲料技术开发有限公司 | Prevent and treat the feed addictive of mink colibacillosis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106819622A (en) * | 2016-12-15 | 2017-06-13 | 新昌县柏克动物饲料技术开发有限公司 | Prevent and treat the feed addictive of mink colibacillosis |
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