CN105962887B - A kind of non-intrusion type detection of eyeball tension sensor based on micro-fluidic technologies - Google Patents
A kind of non-intrusion type detection of eyeball tension sensor based on micro-fluidic technologies Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
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Abstract
The invention discloses a kind of non-intrusion type detection of eyeball tension sensor based on micro-fluidic technologies, including contact lens, spiral inductance, edge capacitance and inner ring electric capacity, wherein, contact lens is internally provided with cavity and microfluidic channel；Cavity is connected with microfluidic channel, for depositing fluid, and the trandfer fluid into the microfluidic channel；The amount of the fluid of conveying is by Effect of Intraocular Pressure in the microfluidic channel, and the capacitance of inner ring electric capacity changes with the change of the amount of the fluid conveyed in the microfluidic channel；The CLC loops being made up of edge capacitance, spiral inductance and inner ring electric capacity, realize the detection to intraocular pressure.Detection of eyeball tension sensor in the present invention can effectively solve the problem that the problem of intraocular pressure sensor is not easy to night and monitored, and realize the fluctuations of high-precision, the whole measurement intraocular pressure of 24 hours, have the advantages that simple in construction, easily manufactured, sensitivity is high, dynamic range is big.
Description
Technical field
The invention belongs to technical field of medical instruments, more particularly, to a kind of non-intrusion type based on micro-fluidic technologies
Detection of eyeball tension sensor, the detection of eyeball tension sensor uses C-L-C structures, and being that kind the wireless and passive based on micro-fluidic technologies is non-invades
Enter formula detection of eyeball tension sensor.
Background technology
Glaucoma is first irreversibility diseases causing blindness in the world.Medical research shows that glaucoma is due to pathologic
Intraocular pressure rise causes a kind of disease of characteristic optic nerve lesion and visual field defects.And the rise of intraocular pressure is diagnosis and treatment green light
The important indicator of eye, and study and show, the intraocular pressure of glaucoma patient fluctuated in 24 hours it is larger, typically in sleep and early morning
When reach peak value, and now unless at outpatient service, will not typically carry out the measurement of intraocular pressure.It is achieved that 24 hours of intraocular pressure are complete
Its detection has great importance.The sensor that intraocular pressure can be measured in 24 hours at present is studied by countries in the world, is included
Intrusive mood intraocular pressure sensor and non-intrusion type intraocular pressure sensor.
Use the wireless sourceless sensor form of " L-C resonant tanks " principle more intrusive mood intraocular pressure sensor, will sense
Device is minimized by MEMS process technologies, and intraocular is invaded by surgical operation, with system complex, and heating is big, uncomfortable etc.
Eyes, while it uses intrusion inside ofeye, may be caused irreversible injury by feature.Non-intrusion type intraocular pressure sensor one
As by sensor integration into contact lens, cornea deformation measurement is realized by the way of wireless and passive, thus correspondence go out phase
The intraocular pressure answered.Tonometry in 24 hours of the prior art has utilization " L-C resonance circuits ", also has by foil gauge, two
Person is at present all in laboratory stage.Recently, the U.S. propose non-intrusion type intraocular pressure sensor using micro-fluidic technologies referring to
Paper is (referring to paper " An unpowered, wireless contact lens pressure sensor for point-
Of-care glaucoma diagnosis "), the characteristics of possessing high sensitivity, but it uses shooting style to carry out image procossing
The determination of miniflow body position in microchannel is carried out, it is complicated with equipment costliness, algorithm process, and can not enter during sleep at night
Row measurement the shortcomings of, it is impossible to night people sleep and intraocular pressure peak when intraocular pressure is measured.And Chinese patent literature
" wireless and passive non-intruding MEMS intraocular pressure sensors and preparation method thereof (number of patent application：201510065578.X) " use C-L-
The sensor of C-structure form, it is easily manufactured, but it realizes tonometry using the mode of the change of electric capacity spacing, sensitivity compared with
It is low.
The content of the invention
For the disadvantages described above or Improvement requirement of prior art, microfluid skill is based on it is an object of the invention to provide one kind
The non-intrusion type detection of eyeball tension sensor of art, wherein passing through the structure of each component crucial to it, material and each inter-module
Connected mode etc. is improved, and the problem of intraocular pressure sensor is not easy to night and monitored is can effectively solve the problem that compared with prior art,
Realize high-precision, 24 hours the whole fluctuations for measuring intraocular pressure.
To achieve the above object, according to the invention provides a kind of non-intrusion type detection of eyeball tension biography based on micro-fluidic technologies
Sensor, it is characterised in that including contact lens, spiral inductance, edge capacitance and inner ring electric capacity, wherein,
The contact lens is in spherical crown shape, and for matchingly being pasted with the eyeball shape of patient when wearing
Close；
The edge capacitance and the spiral inductance are respectively positioned on the contact lens；The spiral inductance twist divides
Cloth, the edge capacitance the contact lens circular edge projection in the plane be located at the spiral inductance described
The circular edge of contact lens helical projection in the plane outside；
The inner ring electric capacity is located on the contact lens, circular edge of the inner ring electric capacity in the contact lens
Projection in the plane be located at the spiral inductance the contact lens circular edge spiral shape in the plane
The inside of projection；
One end of the spiral inductance is connected with one end of the edge capacitance, the other end of the spiral inductance with it is described interior
The one end for enclosing electric capacity is connected；The other end of the edge capacitance is connected with the other end of the inner ring electric capacity；
The contact lens is internally provided with cavity and microfluidic channel；The cavity is connected with the microfluidic channel
It is logical, for depositing fluid, and convey into the microfluidic channel fluid；The fluid of conveying in the microfluidic channel
Amount is by Effect of Intraocular Pressure, and the capacitance of the inner ring electric capacity becomes with the change of the amount of the fluid conveyed in the microfluidic channel
Change；The CLC loops being made up of the edge capacitance, the spiral inductance and the inner ring electric capacity, are realized to the intraocular pressure
Detection.
As present invention further optimization, the non-intrusion type detection of eyeball tension sensor based on micro-fluidic technologies is also wrapped
Receiving coil is included, the receiving coil is used to detect what is be made up of the edge capacitance, the spiral inductance and the inner ring electric capacity
The resonant frequency in CLC loops, and judge according to the resonant frequency detected the size of intraocular pressure.
As present invention further optimization, the inner ring electric capacity is capacity plate antenna, and the microfluidic channel is flat positioned at this
Between two capacitor plates of plate electric capacity.
As present invention further optimization, the capacitance of the edge capacitance is at least the inner ring capacitance value
4 times；It is preferred that, the inductance value of the spiral inductance is 50nH~500nH, the capacitance of the edge capacitance for 46.9pF~
71.4pF, the capacitance of the inner ring electric capacity is 10.7pF~16.05pF.
As present invention further optimization, the cavity is multiple, and this multiple cavities is respectively positioned on the contact lens
Inside, the center of the cavity the contact lens circular edge projection in the plane along and the Corneal Contact
The circle distribution of the circle of the circular edge of mirror with one heart.
As present invention further optimization, the dimensions of the contact lens be set to diameter 13mm~
18mm。
As present invention further optimization, the height of the microfluidic channel is 10 μm~30 μm, width is 20 μm~
80 μm, total length is 40mm~100mm.
As present invention further optimization, the fluid is glycerine, water or ionic liquid at room temperature.
As present invention further optimization, the contact lens is formed by stacking by hard layer and soft layer；It is described soft
Matter layer is used to directly contact with the eyeball of patient when the contact lens is worn, it is preferred that the soft layer uses PDMS material；
The thickness of the hard layer is 60 μm~80 μm, and the integral thickness of the contact lens is no more than 300 μm；The microfluid
Passage, the spiral inductance, the edge capacitance and the inner ring electric capacity are respectively positioned in the hard layer, it is preferred that the hard layer
Using Parylene, PMMA, PC or PET material.
As present invention further optimization, the cavity is cylindrical, and the tubular height is 80 μm~150
μm, radius is 0.5mm~1mm.
By the contemplated above technical scheme of the present invention, compared with prior art, due to being to use to be based on microfluid skill
The C-L-C structures formation wireless and passive non-intrusion type detection of eyeball tension sensor of art, with simple in construction, easy to make, sensitivity
It is high, dynamic range is big, stability is good, the features such as detect simple.The present invention to intraocular pressure sensing mode by being adjusted, based on micro-
Fluid becomes the principle of dielectric capacitance, had both maintained original CLC structures and has prepared the characteristics of facilitating, it is to avoid the cross-layer of electric capacity and inductance is drawn
Line bonding is connected, and causes the sensor to have high detection sensitivity again.
The present invention is that edge capacitance, spiral inductance and inner ring electric capacity three connect to form CLC loops, edge capacitance, spiral shell
Rotation inductance and inner ring electric capacity three are respectively provided with two conductor wire ends, and one end of spiral inductance is connected with one end of edge capacitance, the spiral shell
The other end of rotation inductance is connected with one end of inner ring electric capacity, and the other end of edge capacitance is connected with the other end of inner ring electric capacity, by
This forms CLC loops.Inner ring electric capacity is preferably capacity plate antenna, and miniflow is distributed between two capacitor plates of the inner ring electric capacity
Body passage, liquid microfluid is distributed in microchannel and microcavity；Influenceed by real-time intraocular pressure, the liquid in microchannel
The amount of microfluid will change, and influence the capacitance of inner ring electric capacity, and eventually affect the resonant frequency in the CLC loops.When
During patient's varieties of intraocular pressure, cause contact lens to deform, cause the extruding adhesive of microcavity to deform, be achieved in liquid microfluid and exist
Movement in microchannel, and microchannel is distributed in the dielectric layer of inner ring electric capacity, due to the movement of liquid microfluid, is caused
Dielectric constant between the inner ring electric capacity of part changes, so as to realize the change of C-L-C loop resonance frequencies, outside is for example, by antenna
Inductance frequency sweep realizes that resonant frequency is detected using Network Analyzer etc., so as to realize that intraocular pressure is detected.Specifically, when patient's eye
During pressure rise, the microfluid in microcavity is pressed into microchannel；Form local true when patient's intraocular pressure is reduced, in microcavity
Sky, because microchannel end is connected with air, atmospheric pressure directly pushes back microfluid in microcavity；Due to liquid in microcavity and microchannel
The cumulative volume of body is constant, constitutes dynamic equilibrium, and equivalent to one pump of microcavity is the same.
In the present invention, the height of microfluidic channel is 10 μm~30 μm, and width is 20 μm~80 μm, total length be 40mm~
100mm；The height of tubular cavity is 80 μm~150 μm, and radius is 0.5mm~1mm；The edge capacitance of initial setting up
Capacitance is more than 4 times of the inner ring capacitance value, for example, the inductance value of spiral inductance is 50nH~500nH, edge electricity
The initial capacitance value of appearance is 46.9pF~71.4pF, and the initial capacitance value of inner ring electric capacity is 10.7pF~16.05pF, by with it is micro-
The cooperation of fluid passage (including microcavity etc.), can measure the intraocular pressure value in the range of 0-65mmHg, sensitive with higher detection
Degree.Spiral inductance contact lens circular edge in the plane be projected as spiral yarn shaped, edge capacitance connects in cornea
The projection of the circular edge institute of mirror in the plane is touched positioned at the spiral yarn shaped outside, circle of the inner ring electric capacity in contact lens
Edge in the plane projection be located at the spiral yarn shaped inside.
Hard layer (such as using Parylene-C materials) in intraocular pressure sensor in the present invention, is unlikely to deform, thus
It may be such that liquid extruding with more to microchannel.Microchannel, spiral inductance, edge capacitance and inner ring capacitance structure are distributed in
In hard layer, when not entering fluid in microchannel, the capacitance and inductance value of itself not malleable improve the essence of detection
Degree.Preferably glycerine of the present invention, water or ionic liquid are as liquid microfluid, and the dielectric constant of glycerine is high and harmless to human eye
Liquid, can the solution miscible with water into certain viscosity so as to being flowed in microchannel, there is detection of eyeball tension sensor good
Sensitivity.
To sum up, the non-intrusion type detection of eyeball tension sensor based on micro-fluidic technologies in the present invention, using C-L-C structures, be
Wireless and passive, non-intrusion type detection of eyeball tension sensor, can realize the daytime measurement of borehole pressure, while the electricity such as glycerine is situated between
Matter constant is high, and sensor has high sensitivity, the characteristics of dynamic range is wide.
Brief description of the drawings
Fig. 1 (a) is the overlooking the structure diagram of the non-intrusion type detection of eyeball tension sensor of the invention based on micro-fluidic technologies；
Fig. 1 (b) is the plan structure of the microcavity of the non-intrusion type detection of eyeball tension sensor of the invention based on micro-fluidic technologies
Schematic diagram；
Fig. 2 is the sectional view of the intraocular pressure sensor, and the sectional view is launched into plane and shown；
Fig. 3 is the intraocular pressure sensor Layered manufacturing principle schematic, and each layer is expanded as plane and shown；
Fig. 4 is the overall schematic of the non-intrusion type detection of eyeball tension sensor based on micro-fluidic technologies of the invention, including ball
Coronal contact lens and the intraocular pressure sensor other assemblies being integrated in the contact lens.
The implication of each reference is as follows in figure：1 is contact lens, and 2 be hard layer, and 3 be soft layer, and 4 is logical for miniflow
Road (i.e. microfluidic channel, microchannel), 5 be liquid microfluid (i.e. fluid), and 6 be microcavity (i.e. cavity), and 7 be spiral inductance, and 8 are
Edge capacitance, 9 be inner ring electric capacity.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.As long as in addition, technical characteristic involved in each embodiment of invention described below
Not constituting conflict each other can just be mutually combined.
Embodiment 1
As shown in Fig. 1 (a), Fig. 2, the non-intrusion type detection of eyeball tension sensor based on micro-fluidic technologies, the eye in the present invention
Pressure detection sensor is kind of the passive non-intrusion type detection of eyeball tension sensor of C-L-C structure wireless based on micro-fluidic technologies, including
Soft contact lens, hard layer, soft layer, microchannel (i.e. microchannel), liquid microfluid, microcavity, spiral inductance, side
Edge electric capacity, inner ring electric capacity, wherein：
Contact lens is in integrally spherical crown shape, and for being pasted when wearing with the progress that matches of eyeball shape of patient
Close；The contact lens is superimposed by hard layer with soft layer to be constituted, and wherein soft layer is directly bonded to each other with patient's cornea；Angle
The dimensions of film contact lense is set to diameter 13mm~18mm；The thickness of hard layer be 60-80 μm, main body by
Parylene-c (i.e. c-type Parylene) material makes, and is unlikely to deform；Soft layer uses PDMS material, with high oxygen permeability, its
Surface can carry out ion modification and make it have biocompatibility, be suitable for cornea and wear；The integral thickness of contact lens is less than
300μm。
Microchannel, spiral inductance, edge capacitance and inner ring capacitance structure are distributed in hard layer；Microcavity can be by being distributed
Small cavity in hard layer and soft layer is collectively constituted (for example, microcavity, microcavity walls can be collectively constituted by hard layer and soft layer
A part is made up of hard layer, and a part is made up of soft layer)；
Microchannel is distributed in the dielectric layer of inner ring electric capacity；The height of microchannel can be 10 μm~30 μm, and width is 20 μ
M~80 μm, overall length can be 40mm~100mm.
Liquid microfluid is distributed in microchannel and microcavity；Liquid microfluid can be high and right for dielectric constants such as glycerine
The harmless liquid of human eye, its can the solution miscible with water into certain viscosity so as in microchannel flow.
The height of microcavity is 80 μm~150 μm, and microcavity can have multiple, is connected between multiple microcavitys.Microcavity is by hard layer
Collectively formed with soft layer, it is multiple to arrange and be interconnected in a ring, when can experience contact lens with this and increasing with intraocular pressure
Maximum distortion, have inlet at initial microcavity, can thus place by the microfluidic liquids such as glycerine inject, after injection, by microcavity " seam
Close ".The microfluidic channel being connected with microcavity, its distal opening, and on the outer surface of keratoscope, be directly connected with air
It is logical；When patient's varieties of intraocular pressure, cause contact lens to deform, cause the extruding adhesive of microcavity to deform, be achieved in liquid micro-
Movement of the fluid in microchannel, and microchannel is distributed in the dielectric layer of inner ring electric capacity, due to the shifting of liquid microfluid
It is dynamic, cause the dielectric constant between the inner ring electric capacity of part to change, so as to realize the change of C-L-C loop resonance frequencies, outside passes through
Detection resonant frequency realizes that intraocular pressure is detected.Specifically, when patient's intraocular pressure is raised, the microfluid in microcavity is pressed into
Into microchannel；When patient's intraocular pressure is reduced, parital vacuum is formed in microcavity, because microchannel end is connected with air, air
Pressure directly pushes back microfluid in microcavity；Because the cumulative volume of microcavity and liquid in microchannel is constant, dynamic equilibrium, microcavity are constituted
Equivalent to one pump is the same.
As shown in Fig. 1 (b), and hard layer microchannel connected interface, i.e., between the electrode pad of capacity plate antenna two
The interface that microfluidic channel is joined directly together；The center of multiple microcavitys contact lens circular edge throwing in the plane
(concentric circles can be multiple to circle distribution of the shadow along the circle concentric with the circular edge of the contact lens, such as Fig. 1 (b) institutes
Show), the projection of microfluidic channel on this plane between the electrode pad of capacity plate antenna two both can be in the concentric circles
Inside, can also need to only adjust corresponding and hard layer microchannel connected interface position in the outside of the concentric circles.
Above-mentioned spiral inductance, edge capacitance and inner ring electric capacity, which are cascaded, constitutes C-L-C resonant tanks, edge capacitance
It is sized so as to much larger than inner ring electric capacity that (generally the capacitance of the edge capacitance of initial setting up is in 46.9pF~71.4pF
In the range of, the capacitance of inner ring electric capacity is in the range of 10.7pF~16.05pF, and the capacitance of edge capacitance is at least inner ring electric capacity
4 times of capacitance；The inductance value of spiral inductance is set to 50nH~500nH), the form connected by using inside and outside electric capacity can make
Sensor construction is simple, rationally distributed, easily manufactured.
As shown in figure 3, the sensor can be divided into 4 layers and process respectively, each layer film passes through photoetching using hierarchical process processing
After being processed etc. technique, it is modified using oxygen ion body/UV treatment, alignment bonding is carried out afterwards and realizes plane formula
Sensor each component and the attachment structure between them.For example, the 2nd layer, the 4th layer includes metal electrode, magnetic can be used
Control sputtering+photoetching+electroplating technique to make, the material used is Cu, and the thickness of this two metal layers is 5 μm~10 μm；
Include microchannel in 2nd layer, the 3rd layer, the 4th layer and draw liquid mouthful, can be using technique systems such as plasma etching, laser ablations
Make；The sensor of plane formula is finally moulding into the curved face type (arc matched with the contact lens of spherical crown shape using pressure sintering
Shape shape) contact lenses intraocular pressure sensor.
The intraocular pressure sensor of wireless and passive in the present invention, is deformed with intraocular pressure by contact lens and realizes liquid in microcavity
Be discharged into microchannel, cause the change of the dielectric constant of inner ring electric capacity.Electric capacity constitutes C-L-C resonant tanks with inductance,
On glasses or frequency scan antenna coil of eye socket etc. can be attached to realize the detection of resonant frequency by external harmoniousness, so as to realize pair
The detection of intraocular pressure.By means of the invention it is possible to realize the intraocular pressure accurate measurement of 24 hours according to the change of resonant frequency, have
Sensitivity is high, and dynamic range is big, and stability is good, the features such as detecting simple.Microcavity in the present invention is except as shown in Fig. 1 (b)
Outside cylindrical, other shapes are can also be, as long as plane where circular edge of the center of multiple microcavitys in contact lens
On even circumferential of the projection along the circle concentric with the circular edge of the contact lens be distributed, such as shown in Fig. 1 (a).
Intraocular pressure sensor in the present invention is flexibility, is the detection of eyeball tension sensor of kind of non-intrusion type.In above-described embodiment,
The hard layer material of contact lens is Parylene Parylene-c, in addition to Parylene, can also be using PC (i.e.,
Polycarbonate, makrolon), PMMA (that is, polymethyl methacrylate, lucite) or PET (that is, poly- terephthaldehydes
Sour glycol ester)；Parylene material can be prepared by chemical vapor deposition method, and the material such as PMMA, PC, PET can use corresponding
It is prepared by film making process.
Liquid microfluid in the present invention can be with higher liquid of dielectric constant such as water, glycerine (from microfluidic liquid viscosity
Angle is set out, it would however also be possible to employ the mixed solution of glycerine and water), ionic liquid at room temperature is can also be, aqueous chemical can be formed
Interface capacitance, electrode/ionic liquid interface capacitance, with high sensitivity.
As it will be easily appreciated by one skilled in the art that the foregoing is merely illustrative of the preferred embodiments of the present invention, it is not used to
The limitation present invention, any modifications, equivalent substitutions and improvements made within the spirit and principles of the invention etc., it all should include
Within protection scope of the present invention.
Claims (8)
1. a kind of non-intrusion type detection of eyeball tension sensor based on micro-fluidic technologies, it is characterised in that including contact lens, spiral shell
Inductance, edge capacitance and inner ring electric capacity are revolved, wherein,
The contact lens is in spherical crown shape, and for matchingly being fitted with the eyeball shape of patient when wearing；
The edge capacitance and the spiral inductance are respectively positioned on the contact lens；The spiral inductance is twist distributed,
The edge capacitance the contact lens circular edge projection in the plane be located at the spiral inductance at the angle
The circular edge of film contact lense helical projection in the plane outside；
The inner ring electric capacity is located on the contact lens, and the inner ring electric capacity is where the circular edge of the contact lens
Projection in plane be located at the spiral inductance the contact lens circular edge helical projection in the plane
Inside；
One end of the spiral inductance is connected with one end of the edge capacitance, the other end of the spiral inductance and inner ring electricity
One end of appearance is connected；The other end of the edge capacitance is connected with the other end of the inner ring electric capacity；
The contact lens is internally provided with cavity and microfluidic channel；The cavity is connected with the microfluidic channel,
For depositing fluid, and convey into the microfluidic channel fluid；The amount of the fluid of conveying in the microfluidic channel
By Effect of Intraocular Pressure, the capacitance of the inner ring electric capacity becomes with the change of the amount of the fluid conveyed in the microfluidic channel
Change；The CLC loops being made up of the edge capacitance, the spiral inductance and the inner ring electric capacity, are realized to the intraocular pressure
Detection；
The inner ring electric capacity is capacity plate antenna, and the microfluidic channel is located between two capacitor plates of the capacity plate antenna；
In addition, being somebody's turn to do the non-intrusion type detection of eyeball tension sensor based on micro-fluidic technologies also includes receiving coil, the receiving coil is used
The resonant frequency in the CLC loops being made up of in detection the edge capacitance, the spiral inductance and the inner ring electric capacity, and according to
The resonant frequency detected judges the size of intraocular pressure.
2. the non-intrusion type detection of eyeball tension sensor as claimed in claim 1 based on micro-fluidic technologies, it is characterised in that the side
The capacitance of edge electric capacity is at least 4 times of the inner ring capacitance value；The inductance value of the spiral inductance be 50nH~
500nH, the capacitance of the edge capacitance is 46.9pF~71.4pF, the capacitance of the inner ring electric capacity for 10.7pF~
16.05pF。
3. the non-intrusion type detection of eyeball tension sensor as claimed in claim 1 based on micro-fluidic technologies, it is characterised in that the chamber
Body is multiple, and this multiple cavities is respectively positioned on the inside of the contact lens, and the center of the cavity is in the contact lens
Circular edge in the plane projection along the circle concentric with the circular edge of the contact lens circle distribution.
4. the non-intrusion type detection of eyeball tension sensor as claimed in claim 1 based on micro-fluidic technologies, it is characterised in that the angle
The dimensions of film contact lense is set to diameter 13mm~18mm.
5. the non-intrusion type detection of eyeball tension sensor as claimed in claim 1 based on micro-fluidic technologies, it is characterised in that state miniflow
The height of body passage is 10 μm~30 μm, and width is 20 μm~80 μm, and total length is 40mm~100mm.
6. the non-intrusion type detection of eyeball tension sensor as claimed in claim 1 based on micro-fluidic technologies, it is characterised in that the stream
Body is glycerine, water or ionic liquid at room temperature.
7. the non-intrusion type detection of eyeball tension sensor as claimed in claim 1 based on micro-fluidic technologies, it is characterised in that the angle
Film contact lense is formed by stacking by hard layer and soft layer；The soft layer be used for when the contact lens is worn and patient eye
Ball is directly contacted, and the soft layer uses PDMS material；The thickness of the hard layer is 60 μm~80 μm, the contact lens
Integral thickness is no more than 300 μm；The microfluidic channel, the spiral inductance, the edge capacitance and the inner ring electric capacity are equal
In the hard layer, the hard layer is using Parylene, PMMA, PC or PET material.
8. the non-intrusion type detection of eyeball tension sensor as claimed in claim 1 based on micro-fluidic technologies, it is characterised in that the chamber
Body is cylindrical, and the tubular height is 80 μm~150 μm, and radius is 0.5mm~1mm.
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| US10898074B2 (en) | 2017-09-09 | 2021-01-26 | Smartlens, Inc. | Closed microfluidic network for strain sensing embedded in a contact lens to monitor intraocular pressure |
| JP2022511932A (en) * | 2018-12-14 | 2022-02-01 | スマートレンズ， インコーポレイテッド | Methods and Devices for Wearable Contact Lenses for Monitoring Intraocular Pressure |
| EP3975824A4 (en) * | 2019-05-31 | 2023-06-14 | Queen's University At Kingston | Intraocular pressure monitoring contact lens |
| CN110292354A (en) * | 2019-07-12 | 2019-10-01 | 华中科技大学 | Based on the contact lenses vision intraocular pressure sensor of strain sensing mechanism and its preparation |
| WO2021079093A1 (en) * | 2019-10-25 | 2021-04-29 | Coopervision International Limited | Tuneable ophthalmic lens |
| CN112022088A (en) * | 2020-09-09 | 2020-12-04 | 中国科学院半导体研究所 | Variable capacitance intraocular pressure sensor based on microfluidics technology and system thereof |
| TWI758937B (en) * | 2020-11-06 | 2022-03-21 | 明基材料股份有限公司 | Contact lenses for intraocular pressure monitoring and manufacturing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6939299B1 (en) * | 1999-12-13 | 2005-09-06 | Kurt Petersen | Implantable continuous intraocular pressure sensor |
| WO2012167597A1 (en) * | 2011-06-06 | 2012-12-13 | The Hong Kong University Of Science And Technology | Surface deformation sensor |
| CN102423258B (en) * | 2011-09-20 | 2013-12-25 | 上海交通大学 | MEMS (Micro Electro Mechanical System) technology-based wireless transmission implantable symmetrical structure pressure sensor |
| CN104545794B (en) * | 2015-02-09 | 2017-04-12 | 中国科学院电子学研究所 | Wireless passive non-invasive MEMS intraocular pressure sensor and manufacturing method thereof |
| CN104545795B (en) * | 2015-02-09 | 2016-09-21 | 中国科学院电子学研究所 | Planar inductor and the wireless connections intraocular pressure sensor of capacitances in series |
-
2016
- 2016-04-13 CN CN201610227328.6A patent/CN105962887B/en not_active Expired - Fee Related
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| CN105962887A (en) | 2016-09-28 |
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