CN105928766B - Biochip point sample instrument and its print table - Google Patents
Biochip point sample instrument and its print table Download PDFInfo
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- CN105928766B CN105928766B CN201610556454.6A CN201610556454A CN105928766B CN 105928766 B CN105928766 B CN 105928766B CN 201610556454 A CN201610556454 A CN 201610556454A CN 105928766 B CN105928766 B CN 105928766B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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Abstract
The present invention relates to biotechnology, discloses a kind of biochip point sample instrument and its print table, print table are set in biochip point sample instrument, including：The platform being correspondingly arranged with the spotting needle of biochip point sample instrument.Platform is equipped at least two resettlement areas for disposing biochip, the two resettlement areas are respectively the first resettlement area and the second resettlement area.Wherein, the first resettlement area is located in the operating area of spotting needle, and the second resettlement area is located at outside the operating area of spotting needle.Print table further includes the driving mechanism for driving platform to move, and driving mechanism band moving platform moves, and enables the first resettlement area and the second resettlement area successively alternately out of and into the operating area of spotting needle.The working efficiency for using the biochip point sample instrument of print table is greatly improved.
Description
Technical field
The present invention relates to biotechnology, more particularly to a kind of biochip point sample instrument and its print table.
Background technology
Biochip technology is also known as micro- display (microarray) technology, by biochemical analysis process integration in chip list
Face, to realize the high throughput quickly detection to biotic component.
So-called biochip refers generally to biological information molecule (such as gene piece that high density is fixed on mutual supporting dielectric
Section, DNA fragmentation or polypeptide, protein, glycan molecule, tissue etc.) microarray hybridization cake core (micro-arrays), in array
The sequence of each molecule and position are known, are pre-set sequence dot matrix, therefore contain a large amount of biological information.
Biochip technology originates from making nucleic acid molecular hybridization, in the biochip of narrow sense, according to special between biomolecule
The principle of interaction, generally can be (oligonucleotides, cDNA, genomic DNA, polypeptide, anti-by biomolecule by distinct methods
Body, antigen etc.) it is bonded in the solid phase mediators such as silicon chip, sheet glass (pearl), plastic sheet (pearl), gel, nylon membrane, form biology point
Sub- dot matrix.
In the production process of biochip, completes fixed action and need to use biochip point sample instrument.So-called biology core
Piece point sample instrument is quickly and accurately to put biological sample on the biochip for waiting for point sample with certain array way, forms life
Object sample is the instrument of array, is the requisite instrumentation for being engaged in biochip research and development and production.
In existing biochip point sample instrument, corresponding its implements the spotting needle of point sample This move, and a use can all be arranged
In the print table of placement biochip, such as in the Chinese utility model patent application No. is CN201220347614, just go out
Show such " sample application platform ".
It was found by the inventors of the present invention that in traditional biochip point sample instrument work, operating personnel usually require to load
The biochip of lot waits for biochip to complete point sample work, then unloads all biochips for completing point sample, finally fills
Carry new a collection of biochip, so cycle repeatedly.
However, since biochip point sample instrument can usually complete the point of more large batch of biochip in a batch
Sample works, therefore load and unload batch of biochip is more time-consuming.And since traditional biochip point sample instrument is loading and unloading
It needs to be in standby in the process, spotting needle will be in idle state at this time, reduce the production efficiency of biochip point sample instrument.
Invention content
The purpose of the present invention is to provide a kind of biochip point sample instrument and its print tables, use the biological core of print table
The working efficiency of piece point sample instrument is greatly improved.
In order to solve the above technical problem, the present invention provides a kind of print tables, are set in biochip point sample instrument, packet
It includes：The platform being correspondingly arranged with the spotting needle of biochip point sample instrument.
Platform is equipped at least two resettlement areas for disposing biochip, the two resettlement areas are respectively first
Resettlement area and the second resettlement area.Wherein, the first resettlement area is located in the operating area of spotting needle, the second resettlement area position
In outside the operating area of spotting needle.
Print table further includes the driving mechanism for driving platform to move, and driving mechanism band moving platform moves, and enables the first peace
Region and the second resettlement area are set successively alternately out of and into the operating area of spotting needle.
The present invention also provides a kind of biochip point sample instruments, are provided with above-mentioned print table.
In terms of existing technologies, biochip point sample instrument provided by the present invention, print table pass through driving mechanism
Carry out band moving platform so that the first resettlement area and the second resettlement area can be within the operating areas of spotting needle in turn.Therefore,
When the first resettlement area is located in the operating area of spotting needle, operating personnel can be to the biological core in the second resettlement area
Piece carries out charge and discharge operations.And once after the completion of the point sample operation in the first resettlement area, it is only necessary to drive platform using driving mechanism
Movement, enables the first resettlement area vacate the working space of spotting needle, then operating personnel can be in biochip point sample instrument pair second
While resettlement area carries out point sample operation, charge and discharge operations are carried out to the biochip in the first resettlement area.In conclusion
Biochip point sample instrument provided by the present invention can preferably utilize standby time of the spotting needle when loading and unloading material, improve
Production efficiency.
Preferably, driving mechanism includes driving motor, the leading screw being connected with the motor shaft of driving motor and setting
In the movable block on leading screw.Platform is connected with movable block.Driving motor drives movable block translation, platform to follow shifting by leading screw
Motion block translates.In the present invention, since biochip is more fragile, it is therefore desirable to more stable driving mechanism.And compared to
For other type of drive, lead screw transmission has the advantages that steady reliable, therefore selects lead screw transmission that can preferably ensure a little
The progress of sample work.
Preferably, print table further includes the N number of fixture being set on platform and in resettlement area, N is natural number.Folder
Tool includes the barrier wall for being set to resettlement area one end, is set to the movable part of the resettlement area other end and is connect with movable part
Movable device.
When biochip is positioned in resettlement area, one end of biochip supports on barrier wall, and the other end is at least
Part is protruded from flat edge of table, forms jag.Movable device drive movable part towards close to barrier wall direction movement and
Movable part is set to support on jag, movable device can also drive movable part to be moved away from the direction of barrier wall.It compares
For existing fixture, in the present invention, since movable device is additionally operable to the direction for driving movable part away from barrier wall
Movement can drive movable part to automatically open fixture behind the working region that resettlement area is detached from spotting needle using movable device,
Therefore the efficiency of loading and unloading can be improved, and prevents the vibrations caused by manually opened fixture, and then prevented caused by vibrations are possible
Spotting needle deviates.
Further, preferably, the position that movable part is in contact with biochip is equipped with flexible pad.Pass through flexible mat
It may caused vibrations when can be formed and be buffered to contact of the movable part with biochip, and then prevent from being closed fixture.
Wherein, preferably, movable device may include Movable motor and rack and pinion assembly.Rack and pinion assembly is distinguished
Connect Movable motor motor shaft and movable part, Movable motor by rack and pinion assembly drive movable part towards closer or far from
The direction of barrier wall moves.Since rack and pinion assembly has better transmission efficiency, lower noise and stronger reliability,
Therefore in the present invention, motor and rack and pinion assembly may be used as driving power source to this movable device.
However, preferably, movable device can also include the fixed seat being oppositely arranged with the side wall of platform, both ends difference
The guide shaft that is connected with the side wall of fixed seat and platform, the spring being placed on guide shaft and at least part are connected with movable part
The magnetic force component connect.
Movable part is socketed on guide shaft, and can be moved along the length direction of guide shaft.Spring is used to that movable part to be pushed to move,
Magnetic force component is for pushing movable part to be moved in the opposite direction towards with the side that spring is pushed.
The movable device constituted using spring and magnetic force component, cost can be cheaper for electric machine structure,
Reliability is also more preferable.
Wherein, magnetic force component can be there are many combination, therefore further, preferably, the both ends of spring can be with
It is separately connected movable part and fixed seat.
Magnetic force component includes the electromagnet being set on the side wall of platform and the permanent magnet that is set on movable part, electromagnet
When power-off, spring pushes movable part and supports movable part on biochip.When electromagnet is powered, electromagnet and permanent magnet phase
Repel, and movable part is pushed to leave biochip.Repulsive force when being powered using electromagnet between permanent magnet, can be with maximum journey
Energy needed for the movement for practicing economy part movement of degree ground, and improve structural reliability.
In addition to this, preferably, platform is divided into an interconnecting piece and at least two loading parts, the two loading stations
It Wei not the first loading part and the second loading part.Wherein, the first resettlement area is located on the first loading part, and the second resettlement area is located at
On second loading part.
Interconnecting piece is sequentially connected with driving mechanism, and the first loading part and the second loading part all detachably connect with interconnecting piece respectively
It connects.Using dismountable first loading part and the second loading part, operating personnel can carry out point sample work in biochip point sample instrument
As when remove entire loading part, and then preferably complete the charge and discharge operations of material.
Further, preferably, interconnecting piece is equipped with connecting pole, loading part is equipped with connection corresponding with connecting pole
Hole.Connecting pole is inserted into connecting hole, forms connection.Since the dismounting of loading part acts frequent occurrence, to the removable of loading part
Its frequency of use and service efficiency should be considered by unloading structure design.For traditional detachable structure, using wearing
Both the connecting pole connections for entering connecting hole, have good reliability.
Description of the drawings
Fig. 1 is schematic diagram when first embodiment of the invention print table is set in biochip point sample instrument；
Fig. 2 is the schematic diagram of first embodiment of the invention print table；
Fig. 3 is schematic diagram of the second embodiment of the invention using motor and the fixture of rack and pinion assembly；
Fig. 4 is that third embodiment of the invention uses spring and magnetic force component, and the both ends of spring are separately connected movable part
With the schematic diagram of the fixture of fixed seat；
Fig. 5 is that third embodiment of the invention uses spring and magnetic force component, and the both ends of spring are separately connected movable part
Enlarged diagram with the fixtures of mesa sidewalls at magnetic force component position；
Fig. 6 is the schematic diagram of four embodiment of the invention print table.
Reference sign：
1- platforms；The first resettlement areas 11-；The second resettlement areas 12-；The first loading parts of 13-；The second loading parts of 14-；
15- interconnecting pieces；16- connecting poles；17- connecting holes；2- spotting needles；3- driving mechanisms；31- driving motors；32- leading screws；33- is moved
Block；4- fixtures；41- barrier walls；42- movable parts；43- movable devices；431- Movable motors；432- rack and pinion assemblies；433-
Fixed seat；434- guide shafts；435- springs；436- magnetic force components；4361- electromagnets；4362- permanent magnets；5- biochips；6- is soft
Property pad.
Specific implementation mode
Embodiment one
The first embodiment of the present invention provides a kind of print table, shown in Figure 1, is set to biochip point sample instrument
It is interior, including：The platform 1 being correspondingly arranged with the spotting needle 2 of biochip point sample instrument.Platform 1 is equipped at least two for disposing
The resettlement area of biochip 5, the two resettlement areas are respectively the first resettlement area 11 and the second resettlement area 12.Wherein,
First resettlement area 11 is located in the operating area of spotting needle 2, and the second resettlement area 12 is located at outside the operating area of spotting needle 2.
Print table further includes the driving mechanism 3 for driving platform 1 to move, and driving mechanism 3 is moved with moving platform 1, enables the
One resettlement area 11 and the second resettlement area 12 are successively alternately out of and into the operating area of spotting needle 2.
In the present embodiment, shown in Figure 2, driving mechanism 3 includes driving motor 31, the motor with driving motor 31
The leading screw 32 that axis is connected and the movable block 33 being set on leading screw 32.Platform 1 is connected with movable block 33.Driving motor
31 drive movable block 33 to translate by leading screw 32, and platform 1 follows movable block 33 to translate.In the present invention, due to biochip 5 compared with
It is frangible for fragility, it is therefore desirable to more stable driving mechanism 3.And for other type of drive, the transmission tool of leading screw 32
Have the advantages that steady reliable, therefore leading screw 32 is selected to be driven the progress that can preferably ensure point sample work.
Print table in actual work, operating process can be as follows：
1, operating personnel install biochip 5 in the first resettlement area 11, are then turned on driving mechanism 3.Driving electricity
Machine 31 is moved by leading screw 32 with moving platform 1 so that the first resettlement area 11 enters in the operating area of spotting needle 2；
2, spotting needle 2 carries out printing operation to the biochip 5 in operating area, meanwhile, it is not in operating area
The second interior resettlement area 12 will be in idle condition；
3, operating personnel install biochip 5 in the second resettlement area 12, and the printing operation of spotting needle 2 is waited for complete；
4, after the completion of point sample, driving mechanism 3 is opened, the second resettlement area 12 enters the operating area of spotting needle 2, and the
Leave operating area in one resettlement area 11；
5, spotting needle 2 can immediately begin to new point sample operation, meanwhile, operating personnel can unload the first resettlement area 11
In completed the biochip 5 of point sample, and load new blank biochip 5.
In terms of existing technologies, print table provided by the present invention by driving mechanism 3 come band moving platform 1 so that
First resettlement area 11 and the second resettlement area 12 can be within the operating areas of spotting needle 2 in turn.Therefore, when the first placement
When region 11 is located in the operating area of spotting needle 2, operating personnel can to the biochip 5 in the second resettlement area 12 into
Row charge and discharge operations.And once after the completion of the point sample operation in the first resettlement area 11, it is only necessary to drive platform 1 using driving mechanism 3
Movement, enables the first resettlement area 11 vacate the working space of spotting needle 2, then operating personnel can be in biochip point sample instrument pair the
While two resettlement areas 12 carry out point sample operation, charge and discharge operations are carried out to the biochip 5 in the first resettlement area 11.It is comprehensive
It is upper described, biochip point sample instrument provided by the present invention, when can preferably utilize idle when loading and unloading material of spotting needle 2
Between, improve production efficiency.
Embodiment two
Second embodiment of the present invention provides a kind of print table, and second embodiment is first embodiment into one
Step is improved, and is mainly theed improvement is that, in second embodiment of the present invention, print table further includes on platform 1 and position
In N number of fixture 4 in resettlement area, N is natural number.The fixture 4 can open and close as needed.
Specifically, shown in Figure 3, by taking the fixture 4 positioned at the first resettlement area 11 as an example, which includes setting
Barrier wall 41, the work that is set to the movable part 42 of the resettlement area other end and is connect with movable part 42 in resettlement area one end
Motivation structure 43.When biochip 5 is positioned in resettlement area, one end of biochip 5 supports on barrier wall 41, and the other end is extremely
Rare part is protruded from the edge of platform 1, forms jag.Movable device 43 drives movable part 42 towards close to barrier wall 41
Direction moves and movable part 42 is made to support on jag, and movable device 43 can also drive movable part 42 away from barrier wall
41 direction movement.Obviously, 4 set-up mode of fixture in the second resettlement area 12 can be identical as the first resettlement area 11,
Can be different, this does not constitute protection scope of the present invention and limits.
It is in the prior art by taking the fixture 4 in the Chinese utility model patent application No. is CN201220347614 as an example
Fixture 4 is typically only capable to support movable part 42 on jag, is formed and is clamped to biochip 5.Since fixture 4 always tends to
It is closed the state of clamping biochip 5, therefore the inconvenience of the handling of biochip 5 will be caused.And in the present embodiment, due to
Movable device 43 can also drive movable part 42 to be moved away from the direction of barrier wall 41, therefore fixture 4 can be as needed
It is opened and closed by control.It is apparent that the fixture 4 for being held in opening state can significantly reduce the difficulty of charge and discharge operations, and then improve life
Produce efficiency.
Since rack and pinion assembly 432 has better transmission efficiency, lower noise and stronger reliability,
Shown in Figure 3 in present embodiment, motor and rack and pinion assembly 432 may be used as driving in this movable device 43
Power source.At this point, movable device 43 includes Movable motor 431 and rack and pinion assembly 432.Rack and pinion assembly 432 connects respectively
Connect the motor shaft and movable part 42 of Movable motor 431, Movable motor 431 by rack and pinion assembly 432 drive movable part 42 to
The direction movement closer or far from barrier wall 41.
Obviously, movable device 43 can also have more kinds of structure type, as long as can drive movable part 42 towards
The movable device 43 of direction movement far from barrier wall 41, can be applied in the present invention.Compared to existing fixture 4
For, it in the present invention, can since movable device 43 is additionally operable to that movable part 42 is driven to move away from the direction of barrier wall 41
Behind the working region that resettlement area is detached from spotting needle 2, to drive movable part 42 to automatically open fixture 4 using movable device 43,
Therefore the efficiency of loading and unloading can be improved, and prevents the vibrations caused by manually opened fixture 4, and then prevented caused by vibrations are possible
Spotting needle 2 deviates.
In addition, in order to cost-effective, by the driven Design for rack and pinion assembly 432, single-unit activity can be enabled electric
Machine 431 drives an entire row even multiple rows of movable part 42 simultaneously.Its specific driven Design scheme can refer to axis in the prior art
Transmission scheme is connected, therefore is no longer repeated in present specification.
In the present embodiment, the position that movable part 42 is in contact with biochip 5 is equipped with flexible pad 6.Pass through flexible pad 6
Son can form the contact with biochip 5 of movable part 42 and buffer, and then prevent from being closed possible caused vibrations when fixture 4.
Obviously, it is further possible to which flexible pad 6 is arranged in the contact site of movable part 42 or remaining drive mechanism and 1 side wall of platform,
And obtain better buffering effect.
Embodiment three
Third embodiment of the present invention provides a kind of print table, and third embodiment and second embodiment are not
Together, it is in place of main difference, in second embodiment of the present invention, movable device 43 uses motor and rack and pinion assembly
432 as driving power source.And in third embodiment of the present invention, movable device 43 uses spring 435 --- magnetic force group
Part 436 is as driving power source.
It more specifically gets on very well, in the present embodiment, shown in Figure 4, movable device 43 includes the side wall with platform 1
Guide shaft 434 that the fixed seat 433 that is oppositely arranged, both ends are connected with the side wall of fixed seat 433 and platform 1 respectively is placed on guide shaft
The magnetic force component 436 that spring 435 and at least part on 434 are connected with movable part 42.
Movable part 42 is socketed on guide shaft 434, and can be moved along the length direction of guide shaft 434.Spring 435 is for pushing
Movable part 42 moves, and magnetic force component 436 is for pushing movable part 42 to be transported in the opposite direction towards with the side that spring 435 is pushed
It is dynamic.
The movable device 43 constituted using spring 435 and the combination of magnetic force component 436, cost can for electric machine structure
With cheaper, reliability is also more preferable.
It specifically gets on very well, shown in Figure 4, the both ends of spring 435 are separately connected movable part 42 and fixed seat 433.Magnetic force
Component 436 includes then the electromagnet 4361 being set on the side wall of platform 1 and the permanent magnet 4362 being set on movable part 42, electricity
When magnet 4361 powers off, spring 435 pushes movable part 42 and supports movable part 42 on biochip 5.Electromagnet 4361 is logical
When electric, electromagnet 4361 repels with 4362 phase of permanent magnet, and movable part 42 is pushed to leave biochip 5.
That is, when electromagnet 4361 is powered, movable part 42 can be with pressuring spring 435, and spring 435 is in
Compressive state, to enable fixture 4 be maintained at open position.Operating personnel can take this opportunity to load and unload biochip 5.It can recognize
For using spring 435 --- movable device 43 of the magnetic force component 436 as driving power source, compared to motor --- gear teeth
It is more energy saving for the structure of bar assembly 432, and due to being not necessarily to calibrate motor, have preferably long
Phase reliability.
Obviously, Fig. 4 displayings is only the preferred drive scheme of one of which, and in Fig. 4, the both ends of spring 435 connect respectively
It takes over a job moving part 42 and fixed seat 433.However, the pushing direction of magnetic force component 436 and spring 435 can be interchanged.For example, ginseng
As shown in Figure 5, the both ends of spring 435 are separately connected the side wall of movable part 42 and platform 1, and spring 435 is for pushing movable part 42
Leave biochip 5.
At this point, if electromagnet 4361 does not change position, when electromagnet 4361 can be enabled to be powered mutually with permanent magnet 4362
Attract, to support movable part 42 on biochip 5.And if electromagnet 4361 change position, can also as shown in figure 5,
Electromagnet 4361 is arranged in fixed seat 433, permanent magnet 4362 is set on movable part 42 close to the one side of fixed seat 433,
And it is mutually exclusive with permanent magnet 4362 when electromagnet 4361 being enabled to be powered, and then movable part 42 is supported on biochip 5.
It is of course also possible to repulsive force when being powered using electromagnet 4361 between permanent magnet 4362, it can be utmostly
Ground movement for practicing economy part 42 moves required energy, and improves structural reliability.The magnetic force component 436 being arranged in this way,
For the scheme of opposite Fig. 4 can more power consumption in use, but the advantage is that can be to avoid flexible pad 6 to magnetic force component
436 barrier influences.
It is worth mentioning that in above two set-up mode, permanent magnet 4362 is all disposed on movable part 42.Obviously,
It can also be by the location swap of electromagnet 4361 and permanent magnet 4362.But, it is contemplated that the kinetic characteristic of movable part 42, in activity
When electromagnet 4361 being arranged on part 42, power cord is sought connections on movable part 42, and reliability is poor, therefore is not appropriate for conduct
Preferred embodiment.However, it will be understood by those of ordinary skill in the art that, it is based only on the simple position that the basis of this programme is made
Set exchange, it should also be included within the protection domain of this patent.
Embodiment four
The 4th embodiment of the present invention provides a kind of print table, and the 4th embodiment is above-mentioned first, second, third
Being further improved for embodiment, mainly thes improvement is that, shown in Figure 6 in the 4th embodiment of the present invention, puts down
Platform 1 is divided into an interconnecting piece 15 and at least two loading parts.
Specifically, the two loading parts are respectively the first loading part 13 and the second loading part 14.Wherein, the first settlement
Domain 11 is located on the first loading part 13, and the second resettlement area 12 is located on the second loading part 14.
Interconnecting piece 15 and driving mechanism 3 are sequentially connected, the first loading part 13 and the second loading part 14 all respectively with interconnecting piece
15 are detachably connected.
Using 13 and second loading part 14 of dismountable first loading part, operating personnel can biochip point sample instrument into
Row point sample removes entire loading part when working.Since operating personnel are when loading and unloading biochip 5 on the loading part removed, not
The point sample work of biochip point sample instrument can be impacted, therefore the loading part of design for disassembly can help operating personnel more
The charge and discharge operations of material are completed well.
Obviously, the detachable scheme of the first loading part 13 and the second loading part 14 can there are many.Present embodiment provides
A kind of preferred detachable scheme, specifically, interconnecting piece 15 is equipped with connecting pole 16, and loading part is equipped with and connecting pole 16
Corresponding connecting hole 17.Connecting pole 16 is inserted into connecting hole 17, forms connection.
Since the dismounting of loading part acts frequent occurrence, the detachable structure design of loading part should be considered
Its frequency of use and service efficiency.For traditional detachable structure, connected using the connecting pole 16 for penetrating connecting hole 17
Both connect, there is good reliability.
Obviously, in the present embodiment, shown in Figure 6, connecting pole 16 is penetrated from the bottom of loading part in connecting hole 17.
However in actual use, connecting pole 16 is not necessarily to penetrate from bottom, particularly, it is contemplated that the thickness of loading part is usual
Relatively thin, the length of connecting pole 16 is limited when being penetrated from bottom.Therefore connecting hole 17 can also be arranged in the side of loading part
Wall, and connecting pole 16 is enabled to penetrate loading part from the side wall of loading part.Thus, can further increase be detachably connected it is steady
Qualitative and reliability.
And further, connecting hole 17 could be provided as blind hole, and most by the end of connecting pole 16 and connecting hole 17
By magnetic connection between depths, and then prevent loading part from being slid along the length direction of connecting pole 16.
Embodiment five
The 5th embodiment of the present invention provides a kind of biochip point sample instrument, is provided on the biochip point sample instrument
The print table that above-mentioned each embodiment is provided.
It in the present embodiment, can be by each automation component of print table, such as driving mechanism 3, movable device 43
It is connected Deng the control system with biochip point sample instrument, to realize the electric automatization control of these components.
Comprehensive foregoing teachings, in terms of existing technologies, biochip point sample instrument provided by the present invention, print table
By driving mechanism 3 come band moving platform 1 so that the first resettlement area 11 and the second resettlement area 12 can be in the works of spotting needle 2
Within industry region in turn.Therefore, when the first resettlement area 11 is located in the operating area of spotting needle 2, operating personnel can be right
Biochip 5 in the second resettlement area 12 carries out charge and discharge operations.And the point sample operation once in the first resettlement area 11 is complete
Cheng Hou, it is only necessary to drive platform 1 to move using driving mechanism 3, enable the first resettlement area 11 vacate the working space of spotting needle 2, then
Operating personnel can be while the second resettlement area of biochip point sample instrument pair 12 carries out point sample operation, to being in the first placement
The biochip 5 in region 11 carries out charge and discharge operations.In conclusion biochip point sample instrument provided by the present invention, it can be more preferable
Ground utilizes standby time of the spotting needle 2 when loading and unloading material, improves production efficiency.
It will be understood by those skilled in the art that in above-mentioned each embodiment, in order to keep reader more preferably geographical
It solves the application and proposes many technical details.But even if without these technical details and based on the respective embodiments described above
Various changes and modifications can also realize each claim of the application technical solution claimed substantially.Therefore, in reality
In, can to the above embodiment, various changes can be made in the form and details, without departing from the spirit and scope of invention.
Claims (6)
1. a kind of print table, is set in biochip point sample instrument, including：With the spotting needle (2) of the biochip point sample instrument
The platform (1) being correspondingly arranged；
It is characterized in that：The platform (1) is equipped at least two resettlement areas for disposing biochip (5), the two
Resettlement area is respectively the first resettlement area (11) and the second resettlement area (12)；Wherein, the first resettlement area (11) position
In in the operating area of the spotting needle (2), second resettlement area (12) is located at the operating area of the spotting needle (2)
Outside；
The print table further includes the driving mechanism (3) for driving the platform (1) to move, and the driving mechanism (3) drives
The platform (1) movement, enable first resettlement area (11) and second resettlement area (12) alternately leave successively with
Into the operating area of the spotting needle (2)；
The print table further includes the N number of fixture (4) being set on the platform (1) and in the resettlement area, and the N is
Natural number；
The fixture (4) includes the barrier wall (41) for being set to described resettlement area one end, it is another to be set to the resettlement area
The movable part (42) at end and the movable device (43) being connect with the movable part (42)；
When the biochip (5) is positioned in the resettlement area, one end of the biochip (5) is supported in the blocking
On wall (41), the other end at least part is protruded from the edge of the platform (1), forms jag；
The movable device (43) drives the movable part (42) to make institute towards close to the movement of the direction of the barrier wall (41)
It states movable part (42) to support on the jag, the movable device (43) can also drive the movable part (42) towards remote
Direction movement from the barrier wall (41)；
The movable device (43) include the fixed seat (433) being oppositely arranged with the side wall of the platform (1), both ends respectively with institute
State the guide shaft (434) that fixed seat (433) is connected with the side wall of the platform (1), the spring being placed on the guide shaft (434)
(435) and at least partially the magnetic force component (436) being connected with the movable part (42)；
The movable part (42) is socketed on the guide shaft (434), and can be moved along the length direction of the guide shaft (434)；
The spring (435) is for pushing the movable part (42) to move, and the magnetic force component (436) is for pushing the movable part
(42) it is moved in the opposite direction towards with the side that the spring (435) is pushed；
The both ends of the spring (435) are separately connected the side wall of the movable part (42) and the platform (1).
2. print table according to claim 1, it is characterised in that：The driving mechanism (3) include driving motor (31), with
The leading screw (32) that the motor shaft of the driving motor (31) is connected and the movable block being set on the leading screw (32)
(33)；The platform (1) is connected with the movable block (33)；
The driving motor (31) drives the movable block (33) to translate by the leading screw (32), and the platform (1) follows institute
State movable block (33) translation.
3. print table according to claim 1, it is characterised in that：The movable part (42) and the biochip (5) phase
The position of contact is equipped with flexible pad (6).
4. print table according to claim 1, it is characterised in that：The platform (1) be divided into an interconnecting piece (15) and
At least two loading parts, the two loading parts are respectively the first loading part (13) and the second loading part (14)；Wherein, described first
Resettlement area (11) is located on first loading part (13), and second resettlement area (12) is located at second loading part
(14) on；
The interconnecting piece (15) is sequentially connected with the driving mechanism (3), and first loading part (13) and described second loads
Portion (14) is all detachably connected with the interconnecting piece (15) respectively.
5. print table according to claim 4, it is characterised in that：The interconnecting piece (15) is equipped with connecting pole (16), institute
It states loading part and is equipped with connecting hole (17) corresponding with the connecting pole (16)；
The connecting pole (16) is inserted into the connecting hole (17), forms connection.
6. a kind of biochip point sample instrument, it is characterised in that：Including the print table described in any one of claim 1 to 5.
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| CN201610556454.6A CN105928766B (en) | 2016-07-15 | 2016-07-15 | Biochip point sample instrument and its print table |
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| CN201610556454.6A CN105928766B (en) | 2016-07-15 | 2016-07-15 | Biochip point sample instrument and its print table |
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| CN105928766B true CN105928766B (en) | 2018-10-26 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107478476A (en) * | 2017-07-31 | 2017-12-15 | 成都博奥晶芯生物科技有限公司 | A kind of dish-style chip point sample instrument and its application method |
| CN108642159B (en) * | 2018-06-27 | 2022-07-01 | 上海宏滩生物科技有限公司 | Biochip detection system |
| CN111665111A (en) * | 2020-07-03 | 2020-09-15 | 上海百傲科技股份有限公司 | Sample applicator |
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