CN105920723A - Electronic capsule capable of releasing accommodated substances quantitatively - Google Patents
Electronic capsule capable of releasing accommodated substances quantitatively Download PDFInfo
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- CN105920723A CN105920723A CN201610339227.8A CN201610339227A CN105920723A CN 105920723 A CN105920723 A CN 105920723A CN 201610339227 A CN201610339227 A CN 201610339227A CN 105920723 A CN105920723 A CN 105920723A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1042—Alimentary tract
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- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Abstract
The invention discloses an electronic capsule capable of releasing accommodated substances quantitatively. The electronic capsule comprises a capsule shell with an opening at one end, a one-way valve is encapsulated at the opening, and an accommodating bin connected with the one-way valve is arranged in the capsule shell; the accommodating bin is divided into a liquid storage bin, an electrolysis bin and a control bin by a piston and a control panel arranged inside, the liquid storage bin, the electrolysis bin and the control bin are used for accommodating a bacterial liquid/medical liquid containing to-be-released substances, electrolyte and control modules respectively, and the liquid storage bin is close to the one-way valve; the release quantity of microorganisms can be controlled quantitatively by controlling electrolysis time. By means of the electronic capsule, enteric microorganisms are more conveniently transplanted, pain of a patient is reduced, the microorganism transplantation quantity is accurately controlled, and the electronic capsule has wide application prospect in the field of clinic application of enteric microorganism transplantation and research of enteric microorganisms.
Description
Technical field
The invention belongs to deglutible medicine releasing capsule technical field, relate to kind and can quantitatively discharge receiving material
Electronic capsule.
Background technology
The enteron aisle of people has hundreds of, the microbe survival of quantity nearly 100,000,000,000,000, constitutes huge and complexity
The ecosystem.In human body there is the relation of mutualism in multiple enteric microorganism and the mankind, to maintaining human body
The physiological function of enteron aisle, nervous function, immunoloregulation function etc. play an important role.And by transplanting
The intestinal microbiota of healthy individuals, transplant particular kind of microorganism, not only treatment pseudomembranous enteritis,
The diseases such as C. difficile infection have good effect, and are alleviating obesity symptom, treatment intestinal inflammatory
Bigger application potential is all had in field.
The method that enteric microorganism is transplanted at present mainly has two kinds.One is that microorganism is made preparation or glue
Capsule, such as bifidobacteria viable bacteria capsule etc., by oral entrance enteron aisle.Although the method is simple, but
Bifidobacterium is exposed to the alimentary canal such as stomach, small intestine just can arrive large intestine, and the most a large amount of bacteriums are being transplanted
Middle death, and it is difficult to the consumption controlling to transplant bacterium.Another kind is that faecal microbiota is transplanted, and one is passed through
Rebuild the method that gut flora treats disease.The method derives the thin of symbiosis from the fecal sample of Healthy People
Bacterium, the mode such as nasogastric tube or nose duodenal tube, gastroscope, rectal catheter bowel lavage is transplanted to patient's stomach and intestine
In road, rebuild the gut flora with normal function.But ight soil graft procedure is complicated, and nasal tube, stomach
Mirror can make patient produce sense of discomfort, affects normal Working Life.
Human body intestinal canal is very sensitive to microbial colonization amount, and transplanting amount is too low to affect the treatment, too high may send out
Raw autogenous infection.If a kind of Bacterial diversity can be realized and can discharge by controlled metered dose in alimentary canal
The electronic capsule of microorganism, can discharge enteric microorganism by controlled metered dose after swallowing in alimentary canal, will be for intestines
The research of road microbial colonization provides strong instrument with clinical practice.At present, it is applied to microorganism release
The digestive tract electronic capsule put not yet sees document and patent.And the current electronics being applied to insoluble drug release
Capsule technique, as disclosed a kind of alimentary tract drug release remote controlled system in Chinese patent CN200610095210.9
System, owing to using spring as driving element, promotes piston by insoluble drug release by disposable, exists
The problem of uncontrollable release amount of medicine, therefore prior art is dfficult to apply to the intestines that need accurately to control consumption
In road microbial colonization application and research.
Summary of the invention
In order to overcome the shortcoming of above-mentioned prior art, it is an object of the invention to provide one can quantitatively discharge
The electronic capsule of receiving material, it is possible to meet the quantitative release of microorganism or medicine, can also when accommodating bacterium solution
Enough make the microorganism in bacterium solution be cultivated or grow, a large amount of enteron aisle before making electronic capsule swallow, can be cultivated
Microorganism, can discharge enteric microorganism or medicine by controlled metered dose in alimentary canal after swallowing, have wide
Application prospect.
The present invention is to be achieved through the following technical solutions:
A kind of electronic capsule that can quantitatively discharge receiving material, including the capsule shell of one end open, opening part
It is packaged with check valve, in capsule shell, is provided with the receiving storehouse being connected with check valve；
Described receiving storehouse is divided into containing liquid chamber, electrolysis storehouse by the piston arranged in it and control panel and controls storehouse,
It is respectively intended to accommodate bacterium solution/liquid, electrolyte and the control module containing thing to be released, and wherein containing liquid chamber leans on
Nearly check valve；
Described control module includes remote control module and the battery providing voltage for it, and remote control module is also distinguished
With run through control panel and stretch into electrolysis storehouse positive and negative electrode be connected.
Can make to produce between positive and negative electrode electromotive force by output voltage when described remote control module is triggered by signal
Difference, the electrolyte in electrolysis storehouse is electrolysed and is produced gas, makes electrolysis storehouse internal gas pressure increase, and piston is therewith
Being pushed to check valve direction, the bacterium solution/liquid in containing liquid chamber is promoted and is released by check valve.
Whether described remote control module is triggered by cordless, exist according to trigger condition and make positive negative electricity
Pole energising or power-off, whether electrolyte produces gas to control it.
Described check valve is that liquid can only be entered by entrance with gas, export the unidirectional by valve of discharge,
Its entrance is positioned at containing liquid chamber, outlet is exposed to outside electronic capsule.
Described bacterium solution/liquid is the bacterium solution containing enteric microorganism or the liquid being dissolved with medicine to be released；
Described bacterium solution be that microbial inoculant is further cultured in the microbial culture medium being placed in containing liquid chamber and
Obtain；
Described liquid is and to be filtered in liquid by medicine dissolving, filtrate is noted and obtains in containing liquid chamber.
The time that described remote control module is triggered controls:
Before remote control module is not triggered, between connected positive and negative electrode, potential-free is poor；
After remote control module is triggered, remote control module output voltage makes to produce between positive and negative electrode electrical potential difference, electricity
The electrolyte of Xie Cangzhong is electrolysed and is produced gas, and piston is made bacterium solution/liquid be released by promotion；Described
Obtaining after testing or for concentration known containing bacteria concentration or containing concentration of bacterium solution/liquid；
According to the relation of electrolysis time-bacterium solution/liquid burst size, by the duration fixing quantity of electrolysis,
Thus the produced gas flow of fixing quantity electrolysis and the actuating length of piston, with the release by bacterium solution/liquid
Volume quantitative controls.
Being encapsulated as of electronic capsule: first placing control module and the control panel with positive and negative electrode, then
In electrolysis storehouse, irrigate electrolyte, after placing piston, irrigate bacterium solution/liquid to containing liquid chamber again, finally use
Check valve encapsulates.
Compared with prior art, the present invention has a following useful technique effect:
The electronic capsule that can quantitatively discharge receiving material that the present invention provides, produces gas based on to electrolyte electrolysis
The electrochemical quantitative control realization of the body fixing quantity to release bacterium solution/liquid: produce with electrolyte electrolysis
Gas increase pressure, as motive force, advances the plunger through check valve unidirectional release bacterium solution/liquid, and passes through
Remote signal to electrolysis the electrifying electrodes time be controlled, thus reach remote signal to electrolysis time-
The fixing quantity of bacterium solution/liquid burst size, such that it is able to realize external signal to control the electronic capsule after swallowing
Accurate quantification release in vitro, overcomes the defect that cannot accurately discharge in prior art.
The electronic capsule that can quantitatively discharge receiving material that the present invention provides, additionally it is possible to realize the release of fixed point,
After electronic capsule is swallowed, owing to have employed check valve to open packages so the gas of outside and liquid
Cannot be introduced into and the gas of inside and liquid also will not be revealed in the case of not having thrust, thus ensure
Electronic capsule keeps relatively steady state during walking again, will not produce the omission of medicine；
By arranging or dress signal triggering device at privileged site after electronic capsule is swallowed, work as electronic capsule
After reaching this position, remote control module is triggered, thus starts to discharge the bacterium solution/liquid accommodated and reach fixed point
Release；Avoid the medicine of excess intake, especially particularly important, the most specifically for release flora
Flora is released at the position reaching to specify just can play corresponding effect, otherwise can produce harmful effect.
The electronic capsule that can quantitatively discharge receiving material that the present invention provides, carries out the micro-life of enteron aisle accommodating bacterium solution
When the transplanting of thing or release, owing to bacterium solution can be accommodated in containing liquid chamber, can be by expanding after inoculation
Mode realize the increase of micro organism quantity, so on the one hand greatly reduce both enteric microorganism
The workload transplanted, makes enteric microorganism transplant simpler convenient, on the other hand achieves microorganism and moves
The accurate control of the amount of planting.And the capsule shell of the present invention can use the polymer with high-biocompatibility
Material, after swallowing, side effect is little；Carried out the release of microorganism by electronic capsule, subtract as much as possible
Light enteric microorganism transplants misery and the sense of discomfort of patient in implementation process.The development of the present invention will be very
Clinical practice and the development of enteric microorganism correlative study of enteric microorganism transplanting is promoted in big degree.
Accompanying drawing explanation
Fig. 1 is the digestive tract electronic capsule schematic diagram that the present invention can cultivate with quantitative releasing microbe；
Fig. 2 is digestive tract electronic capsule controlled release microorganism schematic diagram of the present invention；
Fig. 3 is that aerobic-type microorganism schematic diagram cultivated by digestive tract electronic capsule of the present invention.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail, described in be to the present invention
Explanation rather than restriction.
Seeing Fig. 1, Fig. 2, a kind of electronic capsule that can quantitatively discharge receiving material, including the glue of one end open
Capsule shell 1, opening part is packaged with check valve 11, is provided with the appearance being connected with check valve 11 in capsule shell 1
Na Cang；
Described receiving storehouse is divided into containing liquid chamber 10, electrolysis storehouse 7 by the piston 8 arranged in it and control panel 4
With control storehouse, it is respectively intended to accommodate containing the bacterium solution/liquid 9 of thing to be released, electrolyte 6 and control module,
Wherein containing liquid chamber 10 is near check valve 11；
Described control module includes remote control module 3 and provides the battery 2 of voltage, remote control module 3 for it
The most respectively with run through control panel 4 and stretch into electrolysis storehouse 7 positive and negative electrode 5 be connected.
Further, positive and negative electrode 5 can be made by output voltage when described remote control module 3 is triggered by signal
Between produce electrical potential difference, electrolysis storehouse 7 in electrolyte 6 be electrolysed and produced gas, in making electrolysis storehouse 7
Air pressure increases, and piston 8 is pushed to check valve 11 direction therewith, bacterium solution/liquid 9 quilt in containing liquid chamber 10
Promote and pass through check valve 11 and be released.
Concrete, piston is between electrolysis storehouse 7 and containing liquid chamber 10, and piston can be in capsule shell inwall
Move freely, and ensure that electrolyte is the most compromised.Containing liquid chamber is by capsule shell inwall, piston 8, unidirectional
Cavity between valve 11 is constituted, and can store bacterium solution/liquid 9.The both positive and negative polarity of electrolysis electrode respectively with remote control
The positive and negative interface of module output is connected by wire.The both positive and negative polarity of battery 1 is defeated with remote control module 3 respectively
The positive and negative interface entering end is connected by wire.
Described remote control module 3 is triggered by cordless, whether exist according to trigger condition make positive and negative
Electrifying electrodes or power-off, whether electrolyte 6 produces gas to control it.
Concrete, described remote control module 3 includes magnetic switch, and its two ends connect and positive and negative electrode respectively
5 are connected；Magnetic switch closes according to the change of external magnetic field or disconnects, and makes positive and negative electrode energising or disconnected
Electricity.
Or, described remote control module 3 includes wireless receiving module and signal processing module, signal transacting
Module, according to wireless receiving module received signal, controls remote control module 3 and exports or stop output voltage,
Make positive and negative electrode energising or power-off.
Described wireless receiving module is also associated with reception antenna, in capsule shell 1 inserted by reception antenna or
It is wound between receiving storehouse inwall, outer wall.
Further, the described button cell that battery 2 is a joint or multi-section serial, total voltage be 1.6V～
5V；
Described positive and negative electrode 5 uses the solid-state conductive material including graphite, elemental metals or alloy；
Described electrolyte 6 uses one or more solution in the strong electrolyte solion of electrolysis aerogenesis
Mixing, electrolyte ion concentration is 0.2mol/L～1mol/L；
Described capsule shell 1 uses the polymeric material with high-biocompatibility.
Further, the kind of electrolytes of described electrolyte 6 includes strong base solution, strong acid solution, strong
Alkali strong acid salt solution, strong base weak acid salting liquid and weak acid strong alkali salt solution；When using the mixing of multiple solution,
Without chemical reaction.
Concrete, electrolyte 6 can use NaOH solution, H2SO4Solution, Na2CO3Solution, HCl
The mixing of one or more in solution or NaCl solution.
Described check valve 11 can only enter by entrance for liquid and gas, export the unidirectional of discharge passes through valve
Door, its entrance is positioned at containing liquid chamber 10, outlet is exposed to outside electronic capsule.
Described bacterium solution/liquid 9 is the bacterium solution containing enteric microorganism or the medicine being dissolved with medicine to be released
Liquid；
Described bacterium solution is to be trained in the microbial culture medium being placed in containing liquid chamber 10 by microbial inoculant again
Support and obtain；
Described liquid is and to be filtered in liquid by medicine dissolving, filtrate is noted and obtains in containing liquid chamber 10
?.
In described bacterium solution, microbial culture medium adopts water as solvent, and is dissolved with growth of microorganism and is musted
The a great number of elements of palpus and trace element；Microbe species be can enteron aisle existence anaerobic type microorganism or
Aerobic-type microorganism, microbe species is single culture or the microorganism species of several microorganism composition.
Concrete, described microbial culture medium adopts water as solvent, in carbohydrate, protein, inorganic salts
One or more mixture of substances are solute, and the bacterium of bacterium solution can be made to breed in this liquid.Microorganism bag
Include the mixing of microorganism present in one or more human body alimentary canals.
Further, the encapsulation of described bacterium solution with cultivation is:
Microbial culture medium is flow in containing liquid chamber 10 and close to fill, then by micro-for anaerobic type enteron aisle life
Thing bacterial classification is inoculated in microbial culture medium, encapsulates to completely cut off outside air with check valve 11；Again by electronics
Capsule stands or is placed on shaking table and cultivates 1～3 day under normal temperature, and the breeding of period anaerobic type enteric microorganism is expanded
Increase.
The encapsulation of described bacterium solution with cultivation is:
Microbial culture medium is flow in containing liquid chamber 10 and close to fill, then by micro-for aerobic-type enteron aisle life
Thing bacterial classification is inoculated in microbial culture medium, containing liquid chamber outlet open wide in the case of again by electronic capsule stand or
It is placed on shaking table and cultivates 1～3 day under normal temperature, keep the circulation of bacterium solution and ambient atmos, period aerobic-type intestines
Road microbial reproduction amplification, encapsulates containing liquid chamber 10 with check valve 11 after having cultivated.
For fixing quantity, the time control that described remote control module 3 is triggered is:
Before remote control module 3 is not triggered, between connected positive and negative electrode 5, potential-free is poor；
After remote control module 3 is triggered, remote control module 3 output voltage makes to produce between positive and negative electrode 5 electromotive force
Difference, the electrolyte 6 in electrolysis storehouse 7 is electrolysed and is produced gas, and piston 8 is made bacterium solution/liquid 9 by promotion
It is released；Obtaining after testing or for known dense containing bacteria concentration or containing concentration of described bacterium solution/liquid 9
Degree；
According to the relation of electrolysis time-bacterium solution/liquid burst size, by the duration fixing quantity of electrolysis,
Thus the produced gas flow of fixing quantity electrolysis and the actuating length of piston 8, with by bacterium solution/liquid 9
Release volume fixing quantity.
Being encapsulated as of electronic capsule: first placing control module and the control panel 4 with positive and negative electrode 5,
Then in electrolysis storehouse 7, irrigate electrolyte 6, after placing piston 8, irrigate bacterium solution to containing liquid chamber 10 again
/ liquid 9, finally encapsulates with check valve 11.
Specific embodiment is given below.
Embodiment 1
As shown in Figure 1, 2, the present embodiment is using anaerobic type microorganism as cultivating and releasing object, magnetic control work
For being described as a example by remote control thereof.
Described remote control module 3 is magnetic switch, such as tongue tube.Its two ends are connected to battery 2 positive pole
With electrolysis electrode 5 positive pole.Magnetic switch can close according to the change of external magnetic field or disconnect.
The release being encapsulated into bacterium solution of electronic capsule includes:
1. configuring certain density solute is NaOH, Na2CO3Or Na2SO4Deng strong electrolyte, concentration
For the electrolyte 6 of 0.2mol/L～1mol/L, it is injected in electrolysis storehouse 7 and almost fills.
2. the microorganism that configuration anaerobic type Institute of Micro-biology needs is (such as bifidobacterium adolescentis, lactic acid bacteria or excrement intestines
Coccus) nutrient solution, flow into rapidly in containing liquid chamber 10 after sterilizing, deoxygenation, and almost fill.By institute
The anaerobic type microorganism fungus kind cultivated is inoculated in the nutrient solution in containing liquid chamber 10, installs rapidly after inoculation
Check valve 11, makes containing liquid chamber completely cut off with ambient atmos, maintains anaerobic environment.
3. make electronic capsule stand or be placed in normal temperature on shaking table to cultivate 1-3 days, this section of time containing liquid chamber 10
In enteric microorganism breed until saturated in a large number.This period also can be by magnetite near making capsule surroundings
Magnetic field strengthen, trigger remote control module 3 magnetic switch, make capsule discharge a little bacterium solution, to check bacterium solution
The density of middle microorganism also verifies that it has reached degree of saturation, in case using.
4. capsule is swallowed, after a few hours, by magnetite in vitro near a certain position of alimentary canal (as caecum,
The colon ascendens, transverse colon etc.), capsule is through this position, and magnetic switch 3 is because of the enhancing of magnetic field intensity
Guan Bi, makes to produce between the positive and negative electrode 5 being connected with output electrical potential difference.Electrolyte in electrolysis storehouse 7
6 occur electrochemical reaction, electrolysis to produce a large amount of gases 12, make electrolysis storehouse internal gas pressure increase, and piston 8 exists
Move to the check valve direction of electronic capsule under the promotion of air pressure.Bacterium solution 9 in containing liquid chamber is due to piston
Impetus, is released to enteron aisle by the bacterium solution 13 of check valve.
5. after electrolysis starts special time (10-15 minute), by magnetite away from health, remote control
The magnetic switch of module disconnects, and the electrical potential difference of positive and negative electrode disappears, and electrolysis stops, thus bacterium solution release stops
Only.
6. the relation of m-burst size when starting according to the electrolysis of capsule, is started by fixing quantity electrolysis
Time, can fixing quantity bacterium solution burst size in the range of certain error.
7. the electronic capsule in alimentary canal passes through defecation from internal discharge.
Embodiment 2
As shown in Figure 2,3, the present embodiment is using aerobic-type microorganism as cultivating and releasing object, channel radio
Letter is described as a example by remote control thereof.
Described remote control module 3 includes reception antenna, insert with capsule in or be wound in inside capsule wall, outer
Between wall.Described remote control module also includes wireless receiving module, signal processing module.Signal processing module
According to wireless receiving module received signal, control output end output or stopping output decomposition voltage.
1. configuring certain density solute is NaOH, Na2CO3Or Na2SO4Strong electrolyte, concentration are
The electrolyte 6 of 0.2mol/L～1mol/L, is injected in electrolysis storehouse 7 and almost fills.
2. the cultivation of the microorganism (such as saccharomycete, gemma liver bacterium etc.) that configuration aerobic-type Institute of Micro-biology needs
Liquid, flows into after sterilizing in containing liquid chamber 10, and almost fills.Check valve 11 is unloaded, will not inoculate
Microbial culture medium flow in containing liquid chamber 10.The nutrient solution of containing liquid chamber 10 will be inoculated a small amount of institute again
The aerobic-type enteric microorganism cultivated, opens wide containing liquid chamber outlet after inoculation.
3. electronic capsule is stood or be placed in normal temperature on shaking table and cultivate 1-3 days, keep bacterium solution 9 with extraneous
The circulation of gas, the aerobe amount reproduction in period electronic capsule containing liquid chamber 10, quantity significantly increases
Add.Period can monitor the density of microorganism in bacterium solution 9 and verify that it has reached degree of saturation.By electronic pastes
Check valve 11 installed by capsule, in case using.
4. capsule is swallowed, after a few hours, send enabled instruction, signal transacting mould to wireless receiving module
Block according to the instruction received, control output end output voltage, make the positive and negative electrode 5 that is connected with output it
Between produce electrical potential difference.Electrolyte 6 in electrolysis storehouse 7 occurs electrochemical reaction, electrolysis to produce a large amount of gases
12, make electrolysis storehouse internal gas pressure increase, piston 8 under the promotion of air pressure to the check valve direction of electronic capsule
Motion.Bacterium solution 9 in containing liquid chamber, due to the impetus of piston, passes through check valve.By check valve
Bacterium solution 13 is released to enteron aisle.
5., after electrolysis starts special time (10-15 minute), send disconnected to wireless receiving module
Opening instruction, signal processing module stops output voltage, positive negative electricity according to the instruction received, control output end
The electrical potential difference of pole 5 disappears, and electrolysis stops, thus insoluble drug release stops.
6. the relation of m-burst size when starting according to the electrolysis of capsule, is started by fixing quantity electrolysis
Time, can fixing quantity bacterium solution burst size in the range of certain error.
7. the electronic capsule in alimentary canal passes through defecation from internal discharge.
For embodiment 1～2, electrolysis storehouse 7 is in air-tight state, during use, and electrolyte 6
The gas produced with electrolysis can not flow out and be released in enteron aisle.Capsule shell 1 uses high-biocompatibility
Material, including photosensitive resin, polytetrafluoroethylene (PTFE), PLA, to avoid body rejection.
For embodiment 1～2, battery 2 voltage and the kind of electrolyte 6, concentration are to Microbiological release speed
Degree has a significant impact.2 joint silver oxide button cell total voltage about 3V generally selected by battery, if battery is electric
Pressing through little meeting makes electrolysis speed the slowest, reduces the ability of electronic capsule Microbiological release；If voltage is excessive
Electrolytic speed can be made too fast, be difficult to accurately control Microbiological release amount.Electrolyte generally uses 0.5mol/L
Sodium hydroxide solution, if concentration of electrolyte is too high, electrolysis speed can be made to slow down, reduce electronic capsule
The ability of Microbiological release；If excessive concentration makes electrolytic speed too fast, it is difficult to accurately control microorganism and releases
High-volume.
For embodiment 1～2, in containing liquid chamber 10, microorganism type also can affect micro-with the type of nutrient solution
Biological rate of release.Before implementing, need detection saturated in specified microorganisms nutrient solution, density
Under conditions of specified microorganisms, the Microbiological release amount of electronic capsule and the relation of time, to instruct electronics
Capsule discharges the duration of the type microorganism, it is achieved the quantitative release of microorganism.
Finally need to illustrate, cultivation based on microorganism set forth above and quantitatively release
The embodiment of digestive tract electronic capsule is merely to illustrate the scheme that this technology can use, and is not limited only to this
Several cases.The present invention uses digestive tract electronic capsule carry out microorganism cultivate and the technology of liquid release
Scheme is modified or replaces on an equal basis, all without departing from the scope of the technical program, all should contain
In the middle of scope of the presently claimed invention.
Claims (15)
1. the electronic capsule that can quantitatively discharge receiving material, it is characterised in that include the glue of one end open
Capsule shell (1), opening part is packaged with check valve (11), is provided with and check valve (11) in capsule shell (1)
The receiving storehouse being connected；
Described receiving storehouse by it arrange piston (8) and control panel (4) be divided into containing liquid chamber (10),
Electrolysis storehouse (7) and control storehouse, it is respectively intended to accommodate and contains the bacterium solution/liquid (9) of thing to be released, electrolysis
Liquid (6) and control module, wherein containing liquid chamber (10) is near check valve (11)；
Described control module includes remote control module (3) and provides the battery (2) of voltage, remote control mould for it
Block (3) the most respectively with run through control panel (4) and stretch into electrolysis storehouse (7) positive and negative electrode (5) be connected
Connect.
Can quantitatively discharge the electronic capsule of receiving material the most as claimed in claim 1, it is characterised in that institute
Can make to produce between positive and negative electrode (5) electricity by output voltage when the remote control module (3) stated is triggered by signal
Potential difference, the electrolyte (6) in electrolysis storehouse (7) is electrolysed and is produced gas, makes electrolysis storehouse (7) interior gas
Pressure increases, and piston (8) is pushed to check valve (11) direction therewith, and the bacterium solution in containing liquid chamber (10)/
Liquid (9) is promoted and is passed through check valve (11) and is released.
Can quantitatively discharge the electronic capsule of receiving material the most as claimed in claim 1 or 2, it is characterised in that
Whether described remote control module (3) is triggered by cordless, exist according to trigger condition and make positive negative electricity
Pole energising or power-off, whether electrolyte (6) produces gas to control it.
Can quantitatively discharge the electronic capsule of receiving material the most as claimed in claim 3, it is characterised in that institute
The remote control module (3) stated includes magnetic switch, and its two ends connect respectively and are connected with positive and negative electrode (5)；
Magnetic switch closes according to the change of external magnetic field or disconnects, and makes positive and negative electrode energising or power-off.
Can quantitatively discharge the electronic capsule of receiving material the most as claimed in claim 3, it is characterised in that institute
The remote control module (3) stated includes wireless receiving module and signal processing module, and signal processing module is according to nothing
Line receiver module received signal, controls remote control module (3) and exports or stop output voltage, make positive and negative
Electrifying electrodes or power-off.
Can quantitatively discharge the electronic capsule of receiving material the most as claimed in claim 5, it is characterised in that institute
The wireless receiving module stated is also associated with reception antenna, and reception antenna is inserted in capsule shell (1) or is wound around
In accommodating between storehouse inwall, outer wall.
Can quantitatively discharge the electronic capsule of receiving material the most as claimed in claim 1 or 2, it is characterised in that
The described button cell that battery (2) is a joint or multi-section serial, total voltage is 1.6V～5V；
Described positive and negative electrode (5) uses the solid-state conductive material including graphite, elemental metals or alloy
Material；
Described electrolyte (6) uses one or more in the strong electrolyte solion of electrolysis aerogenesis molten
The mixing of liquid, electrolyte ion concentration is 0.2mol/L～1mol/L；
Described capsule shell (1) uses the polymeric material with high-biocompatibility, including photosensitive tree
Fat, polytetrafluoroethylene (PTFE), PLA.
Can quantitatively discharge the electronic capsule of receiving material the most as claimed in claim 7, it is characterised in that institute
The kind of electrolytes of the electrolyte (6) stated include strong base solution, strong acid solution, highly basic strong acid salt solution,
Strong base weak acid salting liquid and weak acid strong alkali salt solution；When using the mixing of multiple solution, without chemical reaction.
Can quantitatively discharge the electronic capsule of receiving material the most as claimed in claim 1, it is characterised in that institute
The check valve (11) stated is that liquid can only be entered by entrance with gas, export the unidirectional by valve of discharge,
Its entrance is positioned at containing liquid chamber (10), outlet is exposed to outside electronic capsule.
Can quantitatively discharge the electronic capsule of receiving material the most as claimed in claim 1, it is characterised in that
Described bacterium solution/liquid (9) is the bacterium solution containing enteric microorganism or the liquid being dissolved with medicine to be released；
Described bacterium solution is by microbial inoculant in the microbial culture medium being placed in containing liquid chamber (10) again
Cultivate and obtain；
Described liquid is and to be filtered in liquid by medicine dissolving, filtrate is noted in containing liquid chamber (10)
And obtain.
11. electronic capsules that can quantitatively discharge receiving material as claimed in claim 10, it is characterised in that
In described bacterium solution, microbial culture medium adopts water as solvent, and is dissolved with necessary to growth of microorganism
A great number of elements and trace element；Microbe species is can be in the anaerobic type microorganism or aerobic of enteron aisle existence
Type microorganism, microbe species is single culture or the microorganism species of several microorganism composition.
12. electronic capsules that can quantitatively discharge receiving material as described in claim 10 or 11, its feature
Being, the encapsulation of described bacterium solution with cultivation is:
Microbial culture medium is flow in containing liquid chamber (10) and close to fill, then by anaerobic type enteron aisle
Microorganism fungus kind is inoculated in microbial culture medium, encapsulates with check valve (11) to completely cut off outside air；
Again electronic capsule is stood or be placed on shaking table and cultivate 1～3 day under normal temperature, period anaerobic type enteric microorganism
Breeding amplification.
13. electronic capsules that can quantitatively discharge receiving material as described in claim 10 or 11, its feature
Being, the encapsulation of described bacterium solution with cultivation is:
Microbial culture medium is flow in containing liquid chamber (10) and close to fill, then by aerobic-type enteron aisle
Microorganism fungus kind is inoculated in microbial culture medium, and containing liquid chamber outlet is quiet by electronic capsule again in the case of opening wide
Putting or be placed in and cultivate 1～3 day under normal temperature on shaking table, keep the circulation of bacterium solution and ambient atmos, period is aerobic
The breeding amplification of type enteric microorganism, with check valve (11) encapsulation containing liquid chamber (10) after having cultivated.
14. electronic capsules that can quantitatively discharge receiving material as claimed in claim 1 or 2, its feature exists
In, the time control that described remote control module (3) is triggered is:
Before remote control module (3) is not triggered, between connected positive and negative electrode (5), potential-free is poor；
After remote control module (3) is triggered, remote control module (3) output voltage makes between positive and negative electrode (5)
Producing electrical potential difference, the electrolyte (6) in electrolysis storehouse (7) is electrolysed and is produced gas, piston (8) quilt
Promotion makes bacterium solution/liquid (9) be released；Described bacterium solution/liquid (9) dense containing bacteria concentration or pastille
Degree obtains after testing or is concentration known；
According to the relation of electrolysis time-bacterium solution/liquid burst size, by the duration fixing quantity of electrolysis,
Thus the produced gas flow of fixing quantity electrolysis and the actuating length of piston (8), with by bacterium solution/liquid
(9) release volume fixing quantity.
15. electronic capsules that can quantitatively discharge receiving material as claimed in claim 14, it is characterised in that
Being encapsulated as of electronic capsule: first placing control module and the control panel (4) with positive and negative electrode (5),
Then in electrolysis storehouse (7), electrolyte (6) is irrigated, again to containing liquid chamber (10) after placing piston (8)
Perfusion bacterium solution/liquid (9), finally encapsulates with check valve (11).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610339227.8A CN105920723A (en) | 2016-05-19 | 2016-05-19 | Electronic capsule capable of releasing accommodated substances quantitatively |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610339227.8A CN105920723A (en) | 2016-05-19 | 2016-05-19 | Electronic capsule capable of releasing accommodated substances quantitatively |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105920723A true CN105920723A (en) | 2016-09-07 |
Family
ID=56841908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610339227.8A Pending CN105920723A (en) | 2016-05-19 | 2016-05-19 | Electronic capsule capable of releasing accommodated substances quantitatively |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105920723A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106725634A (en) * | 2017-01-23 | 2017-05-31 | 天津医科大学总医院 | Enteric microorganism gathers capsule |
| CN113769250A (en) * | 2021-09-10 | 2021-12-10 | 安翰科技(武汉)股份有限公司 | Drug delivery capsule |
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| CN113769250B (en) * | 2021-09-10 | 2023-08-04 | 安翰科技(武汉)股份有限公司 | Drug delivery capsule |
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Application publication date: 20160907 |