CN105920684A - Preparation method and detection method for disposable cervical dilating rod - Google Patents
Preparation method and detection method for disposable cervical dilating rod Download PDFInfo
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- CN105920684A CN105920684A CN201610482401.4A CN201610482401A CN105920684A CN 105920684 A CN105920684 A CN 105920684A CN 201610482401 A CN201610482401 A CN 201610482401A CN 105920684 A CN105920684 A CN 105920684A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/42—Gynaecological or obstetrical instruments or methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
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Abstract
The invention discloses a preparation method and a detection method for a disposable cervical dilating rod, and belongs to the field of medicinal apparatuses and instruments. The preparation method disclosed by the invention comprises the following steps: (1) preparing a mixed solution of one or more materials of polyvinylpyrrolidone, polyvinyl alcohol or sodium alginate; (2) adding a surfactant into the solution, stirring uniformly, and placing the solution in a water bath; (3) dipping the mixed solution by using an effective using part of the cervical dilating rod, and drying to obtain the dilating rod. The invention also discloses the detection method for the disposable cervical dilating rod. The dilating rod provided by the invention is high in water absorption rate and large in dilation dimension after absorbing water, and dilates flexibly and completely without falling off; enough pressure can be maintained within enough time after the dilating rod dilates, so that clinical using requirements are greatly met; the detection method for the dilating rod is simple and reliable and accurate in detection, does not pollute detection equipment, provides a new idea for the detection of the dilating rod, and ensures the quality of the dilating rod.
Description
Technical field
The present invention relates to a kind of cervical dilator bar, more particularly, it relates to a kind of one-off cervix dilator bar preparation method and detection
Method.
Background technology
Single use cervical dilator bar is the medical surgical instrument that a kind of department of obstetrics and gynecology are conventional.On the one hand, artificial abortion operation or be
Reduce complication that some high risk pregnancy causes and reduce perinatal mortality rate and the induced labor operation implemented, need cervix uteri connective group
Knit and can effectively soften and expand；On the other hand, as Wicresoft of a kind of gynecological Clinics and Practices technology, cervix dilating is to entering smoothly
The operation of row hysteroscope is extremely important.The different-diameter that the cervical dilator bar of tradition is made up of metal or rigid plastics clinically
Dilator bar, with the mode cervix dilating of the rigid expansion of physics, it is longer that this mode often leads to operating time, causes relatively to patient
Big pain, and easily cause vulneratio uteri, embryo damage and the untoward reaction such as hemorrhage.
At present, in order to realize slowly the expanding of cervix uteri, alleviate that patient is painful, reduce operating difficulty and the generation of complication, people
The water absorption behavior utilizing the medical macromolecular materials that biocompatibility is good is made for the slow intumescent with self-expanding performance
One-off cervix dilator bar.But there is expansion rate of water absorption in the dilator bar that currently used self-expanding material and processing technology are made
Low, expanded diameter is less, and will deform under less pressure come off, the problem such as intensity reduction, it is difficult to meet and face
Bed uses demand.
Additionally, the intumescent cervical dilator bar made by self-expanding material, when putting into cervical canal and using, can be from surrounding tissue
Absorption moisture expands, it is desirable to the dilator bar after expansion is the most indeformable, and keeps certain time, and therefore dilator bar exists
After completing, need to carry out product quality detection, to have enough expansion pressures after guaranteeing dilator bar imbibition.For
The forcing press of inspection dilator bar is that the sensing by pressure head processes data, and the precision of pressure head and dimensional requirement are very strict,
And if employing forcing press directly contacts dilator bar and detects, the pressure head of forcing press can be made to be polluted by dilator bar, cause detection
Accuracy declines.
Summary of the invention
1. invention to solve the technical problem that
It is an object of the invention to overcome existing intumescent cervical dilator bar and detection method above shortcomings thereof, it is provided that a kind of
One-off cervix dilator bar preparation method and detection method, use technical scheme, and dilator bar water absorption rate is high, after water suction
Dilation dimension is big, expand soft complete, without coming off, and enough pressure can be kept after expanding in time enough, greatly
Meet Clinical practice demand；The detection method of dilator bar is simple and reliable, pollution-free to Tension-pressure tester, and detection is accurate, for
The detection of dilator bar provides new approaches, it is ensured that the product quality of dilator bar.
2. technical scheme
For reaching above-mentioned purpose, the technical scheme that the present invention provides is:
The one-off cervix dilator bar preparation method of the present invention, comprises the following steps:
(1) polyvinylpyrrolidonesolution solution is prepared；
(2) in the polyvinylpyrrolidonesolution solution of step (1), add surfactant, after stirring, be placed in water-bath；
(3) dip mixed solution by effective use part of cervical dilator bar barred body, obtain dilator bar after drying.
Preferably, the concentration of the polyvinylpyrrolidonesolution solution described in step (1) is 0.5%～10%, described in step (2)
Surfactant is (1～50) with the mass ratio of polyvinylpyrrolidone: 100；Step (2) is also optionally added swelling
Agent, this sweller is one or more in sodium alginate, polyvinyl alcohol and gelatin.
The one-off cervix dilator bar preparation method of the present invention, comprises the following steps:
(1) poly-vinyl alcohol solution is prepared；
(2) in the poly-vinyl alcohol solution of step (1), add surfactant, after stirring, be placed in water-bath；
(3) dip mixed solution by effective use part of cervical dilator bar barred body, obtain dilator bar after drying.
Preferably, the concentration of the poly-vinyl alcohol solution described in step (1) is 0.5%～10%, lives in the surface described in step (2)
Property agent and polyvinyl alcohol mass ratio be (1～50): 100；Step is also optionally added sweller in (2), this sweller
For one or more in sodium alginate, polyvinylpyrrolidone and gelatin.
The one-off cervix dilator bar preparation method of the present invention, comprises the following steps:
(1) sodium alginate soln is prepared；
(2) in the sodium alginate soln of step (1), add surfactant, after stirring, be placed in water-bath；
(3) dip mixed solution by effective use part of cervical dilator bar barred body, obtain dilator bar after drying.
Preferably, the concentration of the sodium alginate soln described in step (1) is 0.5%～40%, lives in the surface described in step (2)
Property agent and sodium alginate mass ratio be (1～50): 100；Step is also optionally added sweller in (2), this sweller
For one or more in polyvinyl alcohol, polyvinylpyrrolidone and gelatin.
Preferably, described cervical dilator bar barred body material uses any one in macromolecular material, silica gel or metal；Or,
Described cervical dilator bar barred body is to have silica gel at macromolecular material or metal barred body front end 5～7cm or PVA cotton material is made
The barred body of front cap.
The one-off cervix dilator bar detection method of the present invention, comprises the following steps:
(1) one-off cervix dilator bar is made according to above-mentioned preparation method；
(2) after dilator bar imbibition, dilator bar is wrapped with density and thin film in uniform thickness；
(3) dilator bar being wrapped with uniform thin film is put in Tension-pressure tester, when the pressure head of Tension-pressure tester makes dilator bar become
The force value of Tension-pressure tester is read during shape.
3. beneficial effect
The technical scheme using the present invention to provide, compared with existing known technology, has the advantages that
(1) the one-off cervix dilator bar preparation method of the present invention, method is simple, it is easy to implement, and without expensive making
Equipment, cost of manufacture is low, and the dilator bar produced expands uniformly, and respectively consistent to intensity, product quality is more stable；Dilator bar
Water absorption rate is high, and after water suction, dilation dimension is big, expand soft complete, without coming off, and can keep sufficient in time enough after expanding
Enough pressure, greatly meets Clinical practice demand；
(2) cervical adhesion is owing to cervical canal mucosa is mechanically damaged posterior synechiae, causes neck tube narrow or locking, uses the present invention
The dilator bar that makes of preparation method, soft after expansion, to cervical canal not damaged, the cervix uteri that can effectively prevent cervix uteri postoperative is the most viscous；
(3) the one-off cervix dilator bar preparation method of the present invention, the dilator bar produced, with common metal or plastic expansion rod
Compare, it is not necessary to the dilator bar converting different-diameter successively reaches to expand palace purpose；Compared with existing disposable self-expanding dilator bar,
Dilator bar has and does not rupture, expands rapidly uniform advantage；
(4) the one-off cervix dilator bar detection method of the present invention, the method is simple and reliable, pollution-free to Tension-pressure tester,
Accurately, the detection for dilator bar provides new approaches, it is ensured that the product quality of dilator bar in detection.
Detailed description of the invention
For further appreciating that present disclosure, below the present invention is described in detail.
Scheme one:
The one-off cervix dilator bar preparation method of the present invention, with polyvinylpyrrolidone as substrate, comprises the following steps:
(1) polyvinylpyrrolidonesolution solution is prepared；The concentration of this polyvinylpyrrolidonesolution solution is 0.5%～10% optimal；Poly-second
Alkene pyrrolidone can use one or more mixing in PVP-K12～PVP-K90；
(2) in the polyvinylpyrrolidonesolution solution of step (1), add surfactant, after stirring, be placed in water-bath,
Bath temperature is that room temperature is optimal to 60 DEG C；Surfactant controls in (1～50) with the mass ratio of polyvinylpyrrolidone: 100
Most preferably；Above-mentioned surfactant can use Tween 80 and sucrose fatty acid ester etc.；It addition, in this step, also alternative
Ground adds sweller and plasticizer, and this sweller can use one or more in sodium alginate, polyvinyl alcohol and gelatin,
This plasticizer can use glycerol etc.；
(3) dip mixed solution by effective use part of cervical dilator bar barred body, obtain dilator bar after drying；Dipping mixing
During solution, preferably dip in the way of at the uniform velocity full leaching；Preferably with oven drying when being dried；Above-mentioned cervical dilator bar barred body material
Matter can use any one in macromolecular material, silica gel or metal；Or, cervical dilator bar barred body is macromolecular material or gold
Belong to and there is silica gel or the barred body of front cap that PVA cotton material is made at barred body front end 5～7cm；Can certainly use existing other
Dilator bar barred body material.
Scheme two:
The one-off cervix dilator bar preparation method of the present invention, with polyvinyl alcohol as substrate, comprises the following steps:
(1) poly-vinyl alcohol solution is prepared；The concentration of this poly-vinyl alcohol solution is 0.5%～10% optimal；Polyvinyl alcohol can use
One or more mixing in PVA-1778～PVA-1799；
(2) in the poly-vinyl alcohol solution of step (1), add surfactant, after stirring, be placed in water-bath, water-bath
Temperature is that room temperature is optimal to 60 DEG C；Surfactant controls in (1～50) with the mass ratio of polyvinyl alcohol: 100 is optimal；Above-mentioned
Surfactant can use Tween 80 and sucrose fatty acid ester etc.；It addition, in this step, it is also optionally added sweller
And plasticizer, this sweller can use one or more in sodium alginate, polyvinylpyrrolidone and gelatin, this increasing
Mould agent and can use glycerol etc.；
(3) dip mixed solution by effective use part of cervical dilator bar barred body, obtain dilator bar after drying；Dipping mixing
During solution, preferably dip in the way of at the uniform velocity full leaching；Preferably with oven drying when being dried；Above-mentioned cervical dilator bar barred body material
Matter can use any one in macromolecular material, silica gel or metal；Or, cervical dilator bar barred body is macromolecular material or gold
Belong to and there is silica gel or the barred body of front cap that PVA cotton material is made at barred body front end 5～7cm；Can certainly use existing other
Dilator bar barred body material.
Scheme three:
The one-off cervix dilator bar preparation method of the present invention, with sodium alginate as substrate, comprises the following steps:
(1) sodium alginate soln is prepared；The concentration of this sodium alginate soln is 0.5%～40% optimal；
(2) in the sodium alginate soln of step (1), add surfactant, after stirring, be placed in water-bath, water-bath
Temperature is that room temperature is optimal to 60 DEG C；Surfactant controls in (1～50) with the mass ratio of sodium alginate: 100 is optimal；Above-mentioned
Surfactant can use Tween 80 and sucrose fatty acid ester etc.；It addition, in this step, it is also optionally added sweller
And plasticizer, this sweller can use one or more in polyvinyl alcohol, polyvinylpyrrolidone and gelatin, this increasing
Mould agent and can use glycerol etc.；
(3) dip mixed solution by effective use part of cervical dilator bar barred body, obtain dilator bar after drying；Dipping mixing
During solution, preferably dip in the way of at the uniform velocity full leaching；Preferably with oven drying when being dried；Above-mentioned cervical dilator bar barred body material
Matter can use any one in macromolecular material, silica gel or metal；Or, cervical dilator bar barred body is macromolecular material or gold
Belong to and there is silica gel or the barred body of front cap that PVA cotton material is made at barred body front end 5～7cm；Can certainly use existing other
Dilator bar barred body material.
In above-mentioned scheme one, scheme two and scheme three, polyvinylpyrrolidone (PVP) has good water suction self-expanding
Property, there is the effects such as colloid protection, film property, caking property, solubilising and cohesion simultaneously, also there is dissolving peptizaiton, make system
The dilator bar each several part made expands uniformly；Polyvinyl alcohol (PVA) has good biocompatibility and water suction self-expanding；
Sodium alginate Nantural non-toxic, has good film forming ability and water suction self-expanding performance；Surfactant, can improve and to produce
The hydrophilic on dilator bar surface, makes dilator bar be more prone to imbibition, and can improve the surface tension after dilator bar expands；Sweet
Oil uses as plasticizer, and each composition can be made fully to dissolve, dispersed；Gelatin can slowly soften in imbibition, makes mixing
Liquid is more sticky, has thickening power.
The one-off cervix dilator bar preparation method of the present invention, method is simple, it is easy to implement, and without expensive making apparatus,
Cost of manufacture is low, and the dilator bar produced expands uniformly, and respectively consistent to intensity, product quality is more stable；Dilator bar water absorption rate
Height, after water suction, dilation dimension is big, expand soft complete, without coming off, and enough pressures can be kept after expanding in time enough
Power, greatly meets Clinical practice demand.Further, the dilator bar produced, compared with common metal or plastic expansion rod,
Reach to expand palace purpose without converting the dilator bar of different-diameter successively；Compared with existing disposable self-expanding dilator bar, dilator bar
Have and do not rupture, expand rapidly uniform advantage；After expansion, softness, to cervical canal not damaged, can effectively prevent cervix uteri postoperative
Cervix uteri is the most viscous.
The one-off cervix dilator bar detection method of the present invention, comprises the following steps:
(1) one-off cervix dilator bar is made according to above-mentioned preparation method；
(2) after dilator bar imbibition, dilator bar is wrapped with density and thin film in uniform thickness；
(3) dilator bar being wrapped with uniform thin film is put in Tension-pressure tester, when the pressure head of Tension-pressure tester makes dilator bar become
The force value of Tension-pressure tester is read during shape.
Owing to thin film is uniform and thin, so not resulting in the error of test result；And, detect simple and reliable, pressure is tried
Testing machine pollution-free, accurately, the detection for dilator bar provides new approaches, it is ensured that the product quality of dilator bar in detection.
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1
Take 0.5g polyvinylpyrrolidone (PVP), be placed in stirring container, be slowly added into 99.3g purified water, and add 0.2g
Tween 80, stirs with the rotating speed of 525r/min；After stirring 1h, mixed solution is placed in 40 DEG C of water-baths, dips in dilator bar barred body
Glue is placed on the drying in oven of 40 DEG C, thus obtains cervical dilator bar.After testing, this cervical dilator bar barred body surface filming is complete
Whole, water absorption rate reaches 3 times of expanding material quality, diameter expansion 60%；After being detected by Tension-pressure tester, after imbibition
Dilator bar expand under 0.2N active force completely, without coming off.
Embodiment 2
Take 5g polyvinylpyrrolidone (PVP), be placed in stirring container, be slowly added into 93.95g purified water, and add 0.05gSucrose fatty acid esterWith 1g glycerol, stir with the rotating speed of 525r/min；After stirring 1h, mixed solution is placed in 40 DEG C of water-baths,
Dip in glue with dilator bar barred body and be placed on the drying in oven of 40 DEG C, thus obtain cervical dilator bar.After testing, this cervical dilator bar
Barred body surface filming is complete, and water absorption rate reaches 2.8 times of expanding material quality, diameter expansion 50%；Examined by Tension-pressure tester
After survey, the dilator bar after imbibition expands completely, without coming off under 0.3N active force.
Embodiment 3
Take 10g polyvinyl alcohol (PVA), be placed in stirring container, be slowly added into 89.9g purified water, and add 0.1g Tween 80,
Stir with the rotating speed of 600r/min；After stirring 1h, mixed solution is placed in 60 DEG C of water-baths, dips in glue with dilator bar barred body and be placed on
The drying in oven of 40 DEG C, thus obtain cervical dilator bar.After testing, this cervical dilator bar barred body surface filming is complete, water suction
Rate reaches 3.5 times of expanding material quality, diameter expansion 60%；Expansion after being detected by Tension-pressure tester, after imbibition
Rod expands complete, without coming off under 0.5N active force.
Embodiment 4
Take 10g sodium alginate, be placed in stirring container, be slowly added into 88.9g purified water, and add 1g gelatin and 0.1g tween
80, stir with the rotating speed of 375r/min；Then mixed solution is placed in 40 DEG C of water-baths, dips in glue with dilator bar barred body and be placed on
The drying in oven of 60 DEG C, thus obtain cervical dilator bar.After testing, this cervical dilator bar barred body surface filming is complete partially thick,
Water absorption rate reaches 10 times of expanding material quality, diameter expansion 100%；After being detected by Tension-pressure tester, after imbibition
Dilator bar expands completely, without coming off under 0.8N active force.
Embodiment 5
Take 1g sodium alginate, 5g polyvinylpyrrolidone (PVP), 5g sodium alginate and 5g Tween 80 to be placed in stirring container,
After being uniformly dispersed, it is slowly added into 84g purified water, stirs with the rotating speed of 375r/min；After 100 DEG C of water-baths are dissolved completely, fall
Enter to stir in container；Then mixed solution is placed in 40 DEG C of water-baths, dips in glue is placed on the baking oven of 60 DEG C with dilator bar barred body and dry
Dry, thus obtain cervical dilator bar.After testing, this cervical dilator bar barred body surface filming is complete partially thick, and water absorption rate reaches expansion material
15 times of material quality, diameter expansion 180%；After being detected by Tension-pressure tester, the dilator bar after imbibition is made at 1N
The most lower expansion is complete, without coming off.
Below being schematically described the present invention and embodiment thereof, this description is the most restricted.So, if ability
The those of ordinary skill in territory is enlightened by it, in the case of without departing from the invention objective, without creatively designing and being somebody's turn to do
Frame mode that technical scheme is similar and embodiment, all should belong to protection scope of the present invention.
Claims (8)
1. one-off cervix dilator bar preparation method, it is characterised in that comprise the following steps:
(1) polyvinylpyrrolidonesolution solution is prepared；
(2) in the polyvinylpyrrolidonesolution solution of step (1), add surfactant, after stirring, be placed in water-bath；
(3) dip mixed solution by effective use part of cervical dilator bar barred body, obtain dilator bar after drying.
One-off cervix dilator bar preparation method the most according to claim 1, it is characterised in that: described in step (1)
The concentration of polyvinylpyrrolidonesolution solution is 0.5%～10%, the surfactant described in step (2) and polyvinylpyrrolidone
Mass ratio is (1～50): 100；Step is also optionally added sweller in (2), and this sweller is sodium alginate, poly-second
One or more in enol and gelatin.
3. one-off cervix dilator bar preparation method, it is characterised in that comprise the following steps:
(1) poly-vinyl alcohol solution is prepared；
(2) in the poly-vinyl alcohol solution of step (1), add surfactant, after stirring, be placed in water-bath；
(3) dip mixed solution by effective use part of cervical dilator bar barred body, obtain dilator bar after drying.
One-off cervix dilator bar preparation method the most according to claim 3, it is characterised in that: described in step (1)
The concentration of poly-vinyl alcohol solution is 0.5%～10%, and the surfactant described in step (2) is (1～50) with the mass ratio of polyvinyl alcohol:
100；Step is also optionally added sweller in (2), and this sweller is sodium alginate, polyvinylpyrrolidone and gelatin
In one or more.
5. one-off cervix dilator bar preparation method, it is characterised in that comprise the following steps:
(1) sodium alginate soln is prepared；
(2) in the sodium alginate soln of step (1), add surfactant, after stirring, be placed in water-bath；
(3) dip mixed solution by effective use part of cervical dilator bar barred body, obtain dilator bar after drying.
One-off cervix dilator bar preparation method the most according to claim 5, it is characterised in that: described in step (1)
The concentration of sodium alginate soln is 0.5%～40%, and the surfactant described in step (2) is (1～50) with the mass ratio of sodium alginate:
100；Step is also optionally added sweller in (2), and this sweller is polyvinyl alcohol, polyvinylpyrrolidone and gelatin
In one or more.
7. according to the one-off cervix dilator bar preparation method described in claim 1 or 3 or 5, it is characterised in that: described palace
Neck dilator bar barred body material uses any one in macromolecular material, silica gel or metal；Or, described cervical dilatation stick
Body is to have silica gel at macromolecular material or metal barred body front end 5～7cm or the barred body of front cap that PVA cotton material is made.
8. one-off cervix dilator bar detection method, it is characterised in that comprise the following steps:
(1) one-off cervix dilator bar is made according to the preparation method described in claim 1 to 7 any one；
(2) after dilator bar imbibition, dilator bar is wrapped with density and thin film in uniform thickness；
(3) dilator bar being wrapped with uniform thin film is put in Tension-pressure tester, when the pressure head of Tension-pressure tester makes dilator bar become
The force value of Tension-pressure tester is read during shape.
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| CN201610482401.4A CN105920684B (en) | 2016-06-27 | 2016-06-27 | One-off cervix dilator bar preparation method and detection method |
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| CN201610482401.4A CN105920684B (en) | 2016-06-27 | 2016-06-27 | One-off cervix dilator bar preparation method and detection method |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4237888A (en) * | 1979-03-23 | 1980-12-09 | The Upjohn Company | Two-membrane medicated device for rate-controlled administration of prostaglandins |
| CN1053366A (en) * | 1990-01-20 | 1991-07-31 | 董炳麟 | Hydrophilic polyurethane sponge dilator |
| CN1091041A (en) * | 1993-12-04 | 1994-08-24 | 中国人民解放军优生优育研究中心 | Analgesic dilator for cervix and production technology thereof |
| CN204864503U (en) * | 2015-08-06 | 2015-12-16 | 章由生 | Plasticity expands palace stick |
-
2016
- 2016-06-27 CN CN201610482401.4A patent/CN105920684B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4237888A (en) * | 1979-03-23 | 1980-12-09 | The Upjohn Company | Two-membrane medicated device for rate-controlled administration of prostaglandins |
| CN1053366A (en) * | 1990-01-20 | 1991-07-31 | 董炳麟 | Hydrophilic polyurethane sponge dilator |
| CN1091041A (en) * | 1993-12-04 | 1994-08-24 | 中国人民解放军优生优育研究中心 | Analgesic dilator for cervix and production technology thereof |
| CN204864503U (en) * | 2015-08-06 | 2015-12-16 | 章由生 | Plasticity expands palace stick |
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|---|---|
| CN105920684B (en) | 2019-05-31 |
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