CN105727433A - Micropore medicine patch, precise transdermal medicine delivery system adopting laser impact and medicine delivery method - Google Patents
Micropore medicine patch, precise transdermal medicine delivery system adopting laser impact and medicine delivery method Download PDFInfo
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- CN105727433A CN105727433A CN201610059418.9A CN201610059418A CN105727433A CN 105727433 A CN105727433 A CN 105727433A CN 201610059418 A CN201610059418 A CN 201610059418A CN 105727433 A CN105727433 A CN 105727433A
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- micropore
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a precise transdermal medicine delivery system adopting laser impact. The precise transdermal medicine delivery system comprises a micropore patch and a pulse laser unit used for scanning pulse laser to the micropore patch. The micropore patch comprises an energy converting layer and a medicine storing layer making contact with skin. The medicine storing layer is provided with multiple medicine storing holes used for adsorbing liquid medicine. The energy converting layer absorbs laser pulse energy to generate plasma shock waves, the plasma shock waves act on the liquid medicine in the medicine storing holes to enable the liquid medicine to be injected into the skin. The transdermal medicine delivery system adopting laser impact is high in medicine delivery precision, high in medicine delivery efficiency and wide in medicine delivery range.
Description
Technical field
The present invention relates to armarium and consumptive material field, particularly a kind of micropore plaster and the employing accurate transdermal delivery system of laser-impact and medication.
Background technology
Transdermal administration be a kind of by medicine via special device, enter local organization or blood circulation through skin, it is achieved a class administering mode of disease prevention or treatment.Relative to surgical operation and subcutaneous injection, its process will not bring misery, it is easy to is accepted by patients.Relative to oral administration, the method will not be subject to the impact of the factors such as food in digestive system, pH value, digestive enzyme and the duration of runs.Due to many advantages, Transdermal delivery systems is increasingly subject to the concern of medical circle personage and the favor of patient.
Chinese patent ZL201110243879.9 discloses one " enclosed laser shock wave transdermal administration device "; specifically; it is made up of pulse laser, laser protective casing, condenser lens, restraint layer, absorbed layer, protective layer and liquid medicine box; laser protective casing one end is connected on the laser head of pulse laser; the other end connects liquid medicine box; it so that laser pulse and the scattering light thereof of effect all constrain in laser protective casing, can improve processing safety；Liquid medicine box has set gradually protective layer, absorbed layer and restraint layer; and the thickness sum of absorbed layer and protective layer is the thinnest up to 20 μm; significantly shorten the transmission path of laser blast wave, improve the coupling efficiency of shock wave, reduce the required laser energy in transdermal administration process.Although this device has certain advantage in protecting human body, but it there is also precision in drug administration is not high, administering effect is low problem.
Doukas.G.andN.Kollias (2004). " Transdermaldrugdeliverywitharessurewave. " AdvancedDrugDeliveryReviews56 (5): 559-579. discloses the design of a kind of transdermal delivery device based on laser blast wave principle, records according to the explanation of the 8th page of Fig. 6 and Fig. 6 of its text: rubber ring is bonded on skin by step A by oils and fats；Medicinal liquid is injected in rubber ring by step B；The polymeric material of black is placed on rubber ring and contacts with medicinal liquid by step C；Step D passes through Laser emission arm by Laser emission to the polymer of black；Step E removing polymer material and rubber ring cleaning effect skin position.The method has the advantage that and can effectively be advanced in skin by medicine, but there are some irrational places in this device, namely, the scope that the transdermal administration parts (rubber ring+black polymer) of this device can act on is only small, solution in these transdermal administration parts is thickness, the unbalanced problem of active force when being applied in skin, and then result in the problem that operational efficiency is low, administration range is little, be administered low precision that produces when it coordinates with pulse laser.
Summary of the invention
The accurate transdermal delivery system of employing laser-impact that the main purpose of the present invention is to provide and a kind of is administered precision height, operational efficiency is high, administration range is big.
Technical scheme provided by the invention is: a kind of employing accurate transdermal delivery system of laser-impact, including micropore plaster with for pulse laser scans the pulse laser unit of micropore plaster；Described micropore plaster includes transducing layer and the drug storage layer with contact skin, described drug storage layer is provided with multiple drug storage hole, described drug storage hole is used for adsorbing medicinal liquid, described transducing layer absorbs pulsed laser energy and produces plasma stock wave, described plasma stock wave acts on the medicinal liquid in described drug storage hole, makes medicinal liquid inject skin.
Preferably, described pulse laser unit includes infrared pulsed lasers, scanning galvanometer system, condenser lens and upper computer control system, the pulse laser focusing that described infrared pulsed lasers is launched by described condenser lens is focal beam spot, described upper computer control system presets administration profile, described scanning galvanometer system controls scanning pattern according to default administration profile so that the focal beam spot that described condenser lens focuses on is pointwise progressive scan on described micropore plaster.
Preferably, described upper computer control system also controls the pulsed laser energy of described infrared pulsed lasers.
Preferably, described upper computer control system also controls the scanning speed of described scanning galvanometer system.
Preferably, described micropore plaster also includes the transparent restraint layer for being fixed on skin by micropore plaster, described transducing layer is arranged between restraint layer and drug storage layer, described restraint layer is additionally operable to the plasma that the described transducing layer of constraint produces so that described plasma stock wave travel downward acts on the medicinal liquid in described drug storage hole.
Preferably, the drug storage hole 10 of described drug storage layer 6 is through hole, and drug storage hole 10 dense arrangement on drug storage layer 6 constitutes micro-medicine pond, and the aperture in drug storage hole 10 and the thickness of drug storage layer 6 are micron order.
In the present invention, it is preferred to, the overall structure of micropore plaster is flexible structure, and can be in close contact with skin.
Preferably, drug storage layer thickness is 50～500 μm, the aperture in drug storage hole is 50～300 μm, it should be noted that, drug storage layer and the drug storage hole of the present invention are not limited to above thickness and aperture, in the present invention, the aperture in drug storage hole can have, after reaching micron level, the advantage that medicinal liquid will not overflow when adjusting plaster angle and positive and negative because of capillary increase, what is more important, the suitable degree of depth and the selection in aperture, can speed up drug administration speed during pulsed laser action, make administration more quickly with accurate.
Preferably, transducing layer thickness is 10～300 μm.
In the present invention, restraint layer is not limited to lucite, high transmission rate organic material, high temperature resistant and possess the material of flexibility all can as the restraint layer of the present invention.
In the present invention, transducing layer is not limited to aluminium foil, to the high sheeting of infrared Absorption rate all can as transducing layer, such as the polyethylene sheets of black.
Beneficial effects of the present invention is as follows:
The transdermal delivery system of the present invention, the administration range overcoming traditional drug-supplying system is little, administration low precision, problem that operational efficiency is low.
Specifically, the structure in the many drug storages hole on micropore plaster is especially with after the drug storage pore structure of micron dimension, owing to micro-pore diameter and the degree of depth of microwell plate are micron dimension, therefore medicinal liquid is under capillary effect, it is adsorbed in micropore, form micro-medicine pond that arrangement is regular, micro-medicine pond covers whole administration target area, pulsed laser irradiation is on the transducing layer of micropore plaster, pulsed laser energy is converted to plasma by transducing layer moment, plasma stock wave promotes the medicinal liquid in micro-medicine pond to inject skin, thus realizing the purpose that purported skin is administered by large area.
Further, this transdermal delivery system have employed pulse laser unit and micropore plaster, accurately can be administered by design administration profile, upper computer control system presets administration profile, described scanning galvanometer system controls scanning pattern according to default administration profile, make focal beam spot pointwise progressive scan on described micropore plaster that described condenser lens focuses on, therefore micropore plaster can be carried out the laser scanning of preset range accurately, laser scanning scope can be fixed on affected part very accurately, and affected part is accurately administered.Further, upper computer control system also controls the pulsed laser energy of described infrared pulsed lasers, thus controlling the shock wave size of plasma in administered area, applicable administration thrust can be produced according to dosage demand, upper computer control system also controls the scanning speed of scanning galvanometer system, and then control hot spot application point density on transducing layer, thus controlling the density that in administered area, plasma produces, control administration density.
Accompanying drawing explanation
Fig. 1 is the structural representation of the transdermal delivery system of the embodiment of the present invention 1；
Fig. 2 is the structural representation of the micropore plaster of the embodiment of the present invention 1；
Fig. 3 is the microwell array figure of the drug storage layer of the micropore plaster of the embodiment of the present invention 1.
Each label particularly as follows: 1, infrared pulsed lasers, 2, scanning galvanometer system, 3, condenser lens, 4, micropore plaster, 5, skin, 6, drug storage layer, 7, transducing layer, 8, restraint layer, 9, administration profile, 10, drug storage hole.
Detailed description of the invention
Below in conjunction with detailed description of the invention, technical scheme is described in further detail, but does not constitute any limitation of the invention.
Embodiment 1
As it is shown in figure 1, the accurate transdermal delivery system of laser-impact that adopts of the present invention includes micropore plaster 4 and for pulse laser scans the pulse laser unit of micropore plaster 4；Wherein, pulse laser unit includes infrared pulsed lasers 1, scanning galvanometer system 2, condenser lens 3 and upper computer control system.Described infrared pulsed lasers 1 optical maser wavelength 1064nm, pulse width 100ns, single pulse energy 0.5mJ.The laser beam that infrared pulsed lasers 1 produces is through fiber optic conduction to scanning galvanometer system 2, the focal length of condenser lens 3 is 180mm, and condenser lens 3 is by the focal beam spot that laser beam focus is 50 μm, and scanning galvanometer system 2 controls hot spot and moves, pointwise progressively scans, and covers the administration profile 9 preset.Described administration profile 9 is preset by upper computer control system, specifically can be drawn by computer aided design software, accurate profile can be designed as required, scanning galvanometer system 2 controls scanning pattern according to default administration profile 9, make focal beam spot pointwise progressive scan on micropore plaster 4, cover the administration profile 9 preset, it is achieved large-area accurate administration.Upper computer control system can also control the scanning speed of scanning galvanometer system 2, and then control hot spot application point density on transducing layer, thus controlling the density that in administered area, plasma produces, controlling administration density, the scanning speed adopted in this example is that 100～2000m/s is adjustable.Upper computer control system can also control the pulsed laser energy of infrared pulsed lasers 1, thus controlling the shock wave size of plasma in administered area, it is possible to produce the administration thrust being suitable for according to dosage demand,
Such as Fig. 2, micropore plaster 4 includes transducing layer 7 and the drug storage layer 6 with contact skin, described drug storage layer 6 is provided with multiple drug storage hole 10, drug storage hole 10 is used for adsorbing medicinal liquid, transducing layer 7 absorbs pulsed laser energy and produces plasma, described action of plasma medicinal liquid in described drug storage hole 10, makes medicinal liquid inject skin.
Micropore plaster 4 also includes restraint layer 8, and transducing layer 7 is arranged between restraint layer 8 and drug storage layer 6, and restraint layer 8 retrains the plasma that transducing layer 7 produces so that plasma travel downward acts on the medicinal liquid in drug storage hole 10.
Transparent restraint layer 8 circumferential edges scribbles laminating glue, it is possible to be attached on skin.The transparent restraint layer 8 of the micropore plaster 4 of this example is made up of the lucite that 1mm is thick, diameter 70mm, the aluminum foil thickness that transducing layer 7 adopts be 100 μm, 150 μm and 200 μm of three types any one, diameter is 50mm.
As it is shown on figure 3, the drug storage layer 6 of micropore plaster 4 is made up of PDMS, thickness is 200 μm, and drug storage hole 10 diameter is 100 μm, centre-to-centre spacing 200 μm, arranges in honeycomb array.
Being coated in by liquid medicine on micropore plaster 4, medicinal liquid can be adsorbed in drug storage hole 10, and the restraint layer 8 then passing through micropore plaster 4 is attached on skin 5.CASE(Computer Aided Software Engineering) draws the preset range on administration profile 9 i.e. micropore plaster 4, condenser lens 3 regulates irradiation distance makes laser spot drop on the transducing layer 7 of micropore plaster 4, infrared pulsed lasers 1 starts to irradiate, scanning galvanometer system 2 controls scanning pattern according to default administration profile 9, make focal beam spot pointwise progressive scan on micropore plaster 4, focal beam spot acts on the transducing layer 7 of micropore plaster 4, transducing layer 7 absorbs pulsed laser energy and produces plasma, the mechanical pressure ripple that plasma stock wave produces acts on the medicinal liquid in drug storage hole 10, medicinal liquid is made to pass through the horny layer of skin 5, enter epithelium and skin corium.Transducing layer 7 absorbs laser energy and produces shock wave, improves the permeability of skin within the extremely short time, promotes that medicine enters skin 5, reaches the purpose of percutaneous dosing.And this method hurtless measure, without pain, it is suitable for large area administration, and can to the regional administration of any profile so that percutaneous dosing technology is more accurately efficiently.
Embodiment 2
Being substantially the same with embodiment 1, different places is in that: drug storage layer 6 thickness is 50 μm, and aperture, drug storage hole is 50 μm；The thickness of transducing layer is 10 μm.
Embodiment 3
Being substantially the same with embodiment 1, different places is in that: drug storage layer 6 thickness is 500 μm, and aperture, drug storage hole is 300 μm；The thickness of transducing layer is 300 μm.
The above-described presently preferred embodiments of the present invention that is only, all any amendment, equivalent replacement and improvement etc. made within the scope of the spirit and principles in the present invention, should be included within protection scope of the present invention.
Claims (10)
1. one kind adopts the accurate transdermal delivery system of laser-impact, it is characterised in that include micropore plaster (4) and for pulse laser scans the pulse laser unit of micropore plaster (4)；Described micropore plaster (4) includes transducing layer (7) and the drug storage layer (6) with contact skin, described drug storage layer (6) is provided with multiple drug storage hole (10), described drug storage hole (10) is used for adsorbing medicinal liquid, described transducing layer (7) absorbs pulsed laser energy and produces plasma stock wave, described plasma stock wave acts on the medicinal liquid in described drug storage hole (10), makes medicinal liquid inject skin.
2. the accurate transdermal delivery system of employing laser-impact according to claim 1, it is characterized in that, described pulse laser unit includes infrared pulsed lasers (1), scanning galvanometer system (2), condenser lens (3) and upper computer control system, the pulse laser focusing that described infrared pulsed lasers (1) is launched by described condenser lens (3) is focal beam spot, described upper computer control system presets administration profile, described scanning galvanometer system (2) controls scanning pattern according to default administration profile, make the focal beam spot that described condenser lens (3) focuses in the upper pointwise progressive scan of described micropore plaster (4).
3. the accurate transdermal delivery system of employing laser-impact according to claim 2, it is characterised in that described upper computer control system also controls the pulsed laser energy of described infrared pulsed lasers (1).
4. the accurate transdermal delivery system of employing laser-impact according to claim 3, it is characterised in that described upper computer control system also controls the scanning speed of described scanning galvanometer system (2).
5. according in Claims 1-4, any one adopts the accurate transdermal delivery system of laser-impact, it is characterized in that, described micropore plaster (4) also includes the transparent restraint layer (8) for being fixed on by micropore plaster (4) on skin (5), described transducing layer (7) is arranged between restraint layer (8) and drug storage layer (6), described restraint layer (8) is additionally operable to the plasma that the described transducing layer (7) of constraint produces so that described plasma stock wave travel downward acts on the medicinal liquid in described drug storage hole (10).
6. the accurate transdermal delivery system of employing laser-impact according to claim 5, it is characterized in that, the drug storage hole (10) of described drug storage layer (6) is through hole, drug storage hole (10) constitutes micro-medicine pond in the upper dense arrangement of drug storage layer (6), and the aperture of drug storage hole (10) and the thickness of drug storage layer (6) are micron order.
7. the accurate transdermal delivery system of employing laser-impact according to claim 6, it is characterized in that, described drug storage layer (6) thickness is 50～500 μm, the aperture in drug storage hole (10) is 50～300 μm, and described transducing layer (7) thickness is 10～300 μm.
8. the accurate transdermal delivery system of employing laser-impact according to claim 7, it is characterised in that described restraint layer (8) for high transmission rate and high temperature resistant, possess flexibility organic material.
9. the accurate transdermal delivery system of employing laser-impact according to claim 8, it is characterised in that described transducing layer (7) is the sheeting that infrared Absorption rate is high.
10. the accurate transdermal delivery system of employing laser-impact according to claim 9, it is characterised in that described restraint layer (8) is lucite, described transducing layer (7) is aluminium foil.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610059418.9A CN105727433A (en) | 2016-01-28 | 2016-01-28 | Micropore medicine patch, precise transdermal medicine delivery system adopting laser impact and medicine delivery method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610059418.9A CN105727433A (en) | 2016-01-28 | 2016-01-28 | Micropore medicine patch, precise transdermal medicine delivery system adopting laser impact and medicine delivery method |
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| CN105727433A true CN105727433A (en) | 2016-07-06 |
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| CN201610059418.9A Pending CN105727433A (en) | 2016-01-28 | 2016-01-28 | Micropore medicine patch, precise transdermal medicine delivery system adopting laser impact and medicine delivery method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773488A (en) * | 2020-07-13 | 2020-10-16 | 四川大学 | Laser-driven needle-free injection system |
| CN114832228A (en) * | 2022-07-04 | 2022-08-02 | 中国科学院长春光学精密机械与物理研究所 | Multi-wavelength laser promotes transdermal device of dosing |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006111201A1 (en) * | 2005-04-18 | 2006-10-26 | Pantec Biosolutions Ag | Laser microporator |
| JP2006325700A (en) * | 2005-05-24 | 2006-12-07 | Sparkling Photon Inc | Medicine introducing apparatus using shock wave induced by ultra-short pulse laser |
| CN102397621A (en) * | 2011-08-24 | 2012-04-04 | 南京理工大学 | Enclosed laser shock wave transdermal administration device |
| CN204017140U (en) * | 2014-07-24 | 2014-12-17 | 河南科技大学 | A kind of ultrasonic micropin compound transdermal delivery device |
| CN204913051U (en) * | 2015-09-18 | 2015-12-30 | 广东工业大学 | Implant device based on scanning galvanometer quick travel laser focus |
-
2016
- 2016-01-28 CN CN201610059418.9A patent/CN105727433A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006111201A1 (en) * | 2005-04-18 | 2006-10-26 | Pantec Biosolutions Ag | Laser microporator |
| JP2006325700A (en) * | 2005-05-24 | 2006-12-07 | Sparkling Photon Inc | Medicine introducing apparatus using shock wave induced by ultra-short pulse laser |
| CN102397621A (en) * | 2011-08-24 | 2012-04-04 | 南京理工大学 | Enclosed laser shock wave transdermal administration device |
| CN204017140U (en) * | 2014-07-24 | 2014-12-17 | 河南科技大学 | A kind of ultrasonic micropin compound transdermal delivery device |
| CN204913051U (en) * | 2015-09-18 | 2015-12-30 | 广东工业大学 | Implant device based on scanning galvanometer quick travel laser focus |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773488A (en) * | 2020-07-13 | 2020-10-16 | 四川大学 | Laser-driven needle-free injection system |
| CN114832228A (en) * | 2022-07-04 | 2022-08-02 | 中国科学院长春光学精密机械与物理研究所 | Multi-wavelength laser promotes transdermal device of dosing |
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Application publication date: 20160706 |