CN105640870B - A kind of skin care compositions and methods and skin nursing products containing yeast extract - Google Patents
A kind of skin care compositions and methods and skin nursing products containing yeast extract Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses skin care compositions and methods and skin nursing products containing yeast extract.The skin care compositions and methods include: 5-20 parts of yeast extract；0.1-5 parts of minerals；Peptide (lx10‑5The aqueous solution of % concentration) 5-25 parts；5-10 parts of dendrobium candidum extract；0.1-5 parts of niacinamide；45-85 parts of water.The skin nursing products include 0.01% to about 10% skin care compositions and methods, also include: 0.1% to about 40% oily phase；The aqueous phase of 60% to about 98%；The pH adjusting agent of 0.01% to about 2%；The emulsifier of 3%-10%；The osamine of 0.001% to about 20%；The supplementary element of 0.1% to about 20%.The present invention contains yeast extract, polypeptide, dendrobium candidum extract and several mineral materials simultaneously, can not only keep the skin health colour of skin, but also has desalination wrinkle, repairs skin barrier function, makes skin health, calls forth one's youthful vigor.
Description
Technical field
The present invention relates to the personal care articles of external preparation for skin, it is specifically a kind of containing yeast extract have skin moisture-keeping,
Crease-resistant, reparation, the skin care compositions and methods of whitening function and the skin nursing products containing the skin care compositions and methods.
Background technique
With the promotion of living standard, demand of the consumer to skin care product gradually changes from the appearance modification on basis
For crease-resistant, reparation, whitening, the needs for keeping the multi-functional aspect such as skin health, thus it requires skin care product has functionality
By force, the multiple effects such as safely, effectively.
From the ancient times, yeast is just applied to many aspects of life by the mankind.Before more than 8000 years, medieval people
Begin to plantation cereal when, be known that using yeast and made wine.Archaeologist reports that Babylonian uses yeast
Wound healing is helped, Greek also commonly use the foam that brewing fermentation generates and cleans face and body, keeps skin with this
Health and beauty.
Yeast extract (yeast extract) is that yeast will wherein protein, nucleic acid, vitamin etc. be taken out after broken wall
It mentions, then the substance of the active skull cap components such as the amino acid rich in small molecule, peptide, nucleotide, vitamin through biological enzymolysis.Wherein
30% or more amino acid content, 50% or more total protein, 10% or more nucleotide are mainly used in food, flavouring, cosmetics
Equal fields.Internationally renowned brand adds yeast extract in cosmetics mostly, to desalinate wrinkle and repair skin.
Minerals are substances necessary to growth and development in tissue, are to maintain the essential substance of skin health.Mine
Application of the object in skin care product is also with a long history, can enhance the spongy layer of collagen and elastin laminin, help full flesh
Skin delays wrinkle.Zinc is that wound healing and cell grow required anti-oxidant nutrients.In many enzyme reaction processes, such as protein
DNA and RNA polymerase reaction in synthesis process, and carbonic acid in carbonic anhydrase are converted to the process of carbon dioxide and water
In, zinc works as transport factor, and participates in the biochemical reaction of extracellular matrix.In corium renewal process, especially hurt
Mouth healing plays a key effect.Zinc is able to maintain the intracorporal soda balance of people, maintains ordinary cells normal function.
In recent years, it is received significant attention because of the natural anti-oxidation defence capability with Skin Cell, gradually starts to answer
For cosmetics.Zinc is played the part of emphatically in a kind of forming process of superoxide dismutase (distinctive cellular antioxidants) structure
The role wanted is a part of skin natural defending system.
Copper is the co-factor of many oxidizing ferment, and the absorption and utilization for iron play a key role.It can help to prevent
Only vitamin C aoxidizes, and promotes the synthesis of dermal elastin.Copper can generate disulphide cross-linking agent in cuticula, promote
Natural on-off cycles of hair growth, copper play an important role in the forming process of tyrosinase, and tyrosinase is generated by activation melanocyte
Melanin makes the blackening of skin nature and maintains the black colour of skin, facilitates skin-tightening and elasticity.
Peptide is primarily present in the portions such as human skin, bone, eyes, tooth, tendon, internal organ (including the heart, stomach, intestines, blood vessel)
Position, function are to maintain the form and structure of skin and histoorgan, and repair the important source material substance of each injury tissue.?
In human skin ingredient, it is made of by 70% collagen.It plays the role of supporting skin, referred to as " bone in bone,
Skin in skin ", it is the strong backing of dermal layer of the skin, skin water is tender smooth flexible, mainly the contribution of collagen,
The content of collagen is sufficient in the skin of baby.It may be said that the problem of all skins, such as wrinkle, aging, slack and undisciplined, color spot
Situation is all as caused by the loss of collagen.
Dendrobium candidum is the perennial herbaceous plant that grows nonparasitically upon another plant of orchid family.Effect for oral administration of dendrobium candidum mainly has: Yin-nourishing and body fluid promoting shield
It supports the five internal organs, build up health, improve immunity, strengthening the muscles and bones, resist rheumatism, strengthen the spleen and stomach, cholagogue, control disease in the liver and gallbladder, prevention and treatment sugar
Urine disease inhibits tumour, reduces Radiotherapy chemotherapy side effect, item eyeshield and moisturizing moisturizing, promotes longevity.And dendrobium candidum with
The performance of these upper effects is realized in method for oral administration.Southern Dynasties's Tao Hongjing " book on Chinese herbal medicine is through infusing " is recorded: the long flesh of dendrobium candidum
Meat, by skin heat symptoms caused by an exopathgen miliaria gas.To after the Tang and Song Dynasty, there is the record for much maintaining skin with dendrobium candidum about imperial palace lady,
Famous just has Wu Tse-tien and the Empress Dowager.Active polysaccharide energy human activin rest cell contained by dendrobium candidum, makes cell weight
It newly functions, moreover it is possible to enhance cell viability, if cell is vibrant, the epidermal tissue being made of cell is also just expressively more
It is full glossy.Colloid contained by dendrobium candidum can supplement collagen in human skin；Performance has antibacterial to disappear on the skin
The skin care effects such as scorching, moist moisturizing, injury repair, anti-oxidant.
Niacin and niacinamide are all water soluble vitamins, i.e. vitamin B3.Niacinamide (also referred to as niacinamide) is coenzyme
Nicotinamide adenine dinucleotide (NAD) and the phosphatic constituent of NAD.Nicotinamide deficiency will lead to pellagra, and take orally
Niacinamide is effective to bullous pemphigoid.Topical application niacinamide can reduce transepidermal water loss, improve cuticula moisture
Content.In addition, niacinamide can also promote the synthesis of keratin and ceramide, it was reported that local use niacinamide can reduce
Aging skin of face sallow degree reduces wrinkle, erythema and pigmentation spot.
Summary of the invention
The purpose of the present invention is to provide a kind of skin care compositions and methods containing yeast extract, mention simultaneously containing yeast
Object, polypeptide, dendrobium candidum extract and several mineral materials are taken, the skin health colour of skin can be not only kept, but also there is desalination wrinkle, are repaired
Skin barrier function makes skin health, calls forth one's youthful vigor.
Summary of the invention
" skin nursing products " described herein refer to for handle or nurse or in some way moisturizing, improve skin production
Product, the product covered include but is not limited to moisturizing aqua, Essence, skin nursing cream/frost etc..
Except special instruction, all percentages, number and ratio used herein are in terms of the weight of total composition.
Unless otherwise stated, " environmental condition " used herein refers to about atmospheric pressure, about 50% relative humidity and about 25
DEG C environmental condition.
The present composition may include, by or substantially by component of the invention and as described herein other at grouping
At.Predicate "consisting essentially of ..." used herein refers to composition or component may include supplementary element, as long as described add into
Divide the basic and new characteristic that will not substantially change claimed composition or method.
Herein, " adjust skin " refers to the appearance and/or feeling for improving skin, such as more smooth appearance and/or
Feel.It " adjusts skin " herein and refers to visually and/or obtain in tactile skin appearance and feel that aspect is perceptible
Actively change.The beneficial effect can be chronic beneficial effect and may include one or more of: reduce wrinkle and
Coarse depth line, microgroove, crackle, lump and enlarged pores appearance and increase skin shine, brightness.
The present composition can be used for skin nursing products, and non-limiting purposes includes moisturizer, conditioner, anti-aging
Compound, skin lightening compound and their combination.
Skin nursing products of the invention may also include various other ingredients, will be described below.
Detailed description of the invention
The invention solves first technical problem be to provide with crease-resistant, moisturizing, repair skin containing yeast extract
The skin care compositions and methods of object, non-limiting purposes include moisturizer, conditioner, anti-senescence compounds, skin lightening compound, with
And their combination.
The invention solves second technical problem be to provide containing the skin care compositions and methods containing yeast extract
Skin nursing products.
The invention solves third technical problem be to provide the skin of the skin care compositions and methods containing yeast extract
The preparation method of care product.
In order to solve the first technical problem mentioned above, skin care compositions and methods of the present invention containing yeast extract, comprising as follows
The raw material of parts by weight:
The process of preparing of the above-mentioned skin care compositions and methods containing yeast extract is:
1) preparation of dendrobium candidum aqueous solution:
Dendrobium candidum Dendrobium candidum 100g is taken, 9 times of amount deionized waters are added, after crushing crusher machine, filter
It crosses, extract obtained manufactured solution obtains the dendrobium candidum extracting solution of content 10%.
2) yeast extract, minerals, peptide, dendrobium candidum extract, niacinamide are sequentially added in agitated kettle, addition is gone
Ionized water, mending to weight ratio is 100%, opens stirring 30 minutes to 1 hour, until all materials are sufficiently mixed uniformly, stops stirring
It mixes, it is spare.
The yeast extract is commercial product Biodynes series, Phytohyaluronate (derived from Austria Qi public affairs
Department), yeast essence extract E100, yeast essence G3, yeast essence E300, yeast essence M60 (derive from Angel ferment
It is female), overlay film yeast ferment filtrate, SKHPitera, derived from one of Kashiwayama or a variety of combinations；Preferably, institute
State 30% or more amino acid content in yeast extract, 50% or more total protein content, 10% or more nucleotide content；It is preferred that
Ground, 5-10 parts of yeast extract.
The minerals be commercial product Biomin Marine Acqua-Biomins serial (being all from Qi company difficult to understand) or
One of SEPITONIC M3 (deriving from Seppic) or a variety of combinations；Preferably, minerals 1-3 parts.
The peptide includes but is not limited to dipeptides, tripeptides, tetrapeptide, pentapeptide and hexapeptide and their derivative.It is used herein
" peptide " not only referred to naturally occurring peptide but also refer to synthesis peptide.It can also be used to of the invention be naturally occurring and commercially available group containing peptide
Close object.When being comprised in the present composition, the preferred content of peptide is about lx10 by weight of the composition-6% is extremely
About 10%, even more preferably about lx10-6% is to about 0.5%, even more preferably about lx10-5% to about 0.05%.
The dendrobium candidum extract is the aqueous solution for making 2% by oneself, it is preferable that 5-8 parts of dendrobium candidum extract；
Preferably, niacinamide 2-3 parts；Preferential commercial product, niacinamide PC derive from DSM；Niacinamide derives from Lonza.
To solve above-mentioned second technical problem, a kind of skin nursing production of the skin care compositions and methods containing yeast extract
Product, skin nursing products of the present invention may also include various other ingredients, and specific details are as follows:
Oily phase
Skin nursing products of the invention, the described oil be mutually considered not with it is aqueous miscible, and may include oiliness
Object is closed, such as natural and synthetic oil and other lyophobic dusts that limited solubility is shown in aqueous phase, including but it is unlimited
In oil-soluble ingredients, oil-soluble sun screens and other oil-soluble skin care active substances；Lipoid and oil may be from animal, plant or
Petroleum, and can be natural or synthetic.
Suitable oiliness compound includes ethereal oil and nonvolatile oil, including but not limited to hydrocarbon ils and wax, silicone oil, rouge
The pure and mild derivative of fatty acid of fat, cholesterol, cholesterol derivative, vegetable oil, vegetable oil derivatives, acetin, Arrcostab,
Alkenyl ester, lanolin, wax ester, their salt, isomers and derivative and their combination.
The non-limiting example of non-volatile hydrocarbon ils and wax suitable for this paper include vaseline, mineral oil, microwax,
Polyolefin, paraffin, hydrosqualene, polyalphaolefin, the polyisobutene of hydrogenation and their combination.
The non-limiting example of non-volatile silicone oil suitable for this paper include: dimethicone copolyol,
Dimethicone Crosspolymer, dimethyl polysiloxane, diethyl based polysiloxane, the C1-30 alkyl polysiloxane of mixing, phenyl are poly-
Dimethyl siloxane, dimethiconol and their combination.Dimethicone Crosspolymer suitable for this paper it is non-
Limitative examples include: acrylate/bis-hydroxypropyl Dimethicone Crosspolymer, C30-45 alkyl 16/18
Alkyl dimethicone cross-linked polymer, acrylic ester/bis-hydroxypropyl Dimethicone Crosspolymer, C30-45 alkane
16/octadecyl of base Dimethicone Crosspolymer, 16/octadecyl dimethyl silicone polymer/vinyl are poly-
Dimethicone crosspolymers, Dimethicone Crosspolymer -3, gather Dimethicone Crosspolymer
Dimethyl siloxane/phenyl vinyl Dimethicone Crosspolymer, dimethyl silicone polymer/vinylpolydimethyl
Dimethicone Crosspolymer, diphenyl dimethicone cross-linked polymer, divinyl polydimethylsiloxane/poly- diformazan
Radical siloxane cross-linked polymer, GRANSIL GCM-5 and their mixture.
Ethereal oil for use in the present invention can be selected from component consisting of the following: volatile silicone oils, volatile hydrocarbon and
Their mixture, ethereal oil for use in the present invention can be saturated or unsaturated, can have aliphatic property, and
It and is linear chain or branched chain or comprising alicyclic ring hydrocarbon ring or aromatic ring.
The implementation of preferred volatile hydrocarbon includes the isoparaffin of Permethyl 99A and C12-C15.
The example of preferred volatile silicone oils includes: the cyclo-methicone of various viscosity
(cyclomethicone), such as Dow Corning200, Dow Corning244, Dow Corning245, Dow
Corning344 and DowCorning345 (deriving from Dow Corning Corp.)；SF-1204 and SF-1202 organosilicon liquid
(deriving from MOMENTIVE) and KF-995 (deriving from Shin-Etsu Chemical).The preferred example packet of Linear volatile silicone
Include KF-96A-1cs, KF-96L-1.5cs, KF-96L-2cs, KF-96A-5cs (deriving from Shin-Etsu Chemical).Branch
The preferred example of the volatile silicone oils of chain includes TMF-1.5 (deriving from Shin-Etsu Chemical).
Aqueous phase
Skin nursing products of the present invention include continuous aqueous phase, and the aqueous phase includes aqueous carrier and thickener.It is described
Aqueous phase can further include other hydroaropic substances that limited solubility is shown in oily phase, it is including but not limited to water-soluble at
Point, water-soluble sunscreens and other water-soluble skin care active materials.
The composition includes about 60% to about 98%, the aqueous phase of preferably from about 65% to about 95%.
Aqueous carrier
Aqueous phase of the invention includes aqueous carrier to provide continuous phase.According to compatibility and the product institute with other components
The other characteristics needed select the content and type of the carrier.
It include the aqueous solution of water and lower alkyl alcohol for carrier of the invention.It is tool for lower alkyl alcohol of the invention
There are the monohydric alcohol of 1 to 6 carbon atom, more preferable ethyl alcohol.Preferably, aqueous carrier is substantially water.It is preferable to use deionized waters.
The water from natural source comprising mineral cation also can be used, characteristic needed for this depends on product.
The pH of the present composition is preferably from about 4 to about 8.It, can be by pH tune when in aqueous phase including skin benefit agent
Section is that can provide the value of active skin benefit agents optimal efficacy.It may include buffer and other pH tune to obtain required pH
Save agent.Suitable pH adjusting agent includes acetate, phosphate, citrate, sodium hydroxide, triethanolamine, amino methyl herein
Propyl alcohol and carbonate.
Thickener
Aqueous phase of the invention includes about 0.1% to about 3%, the thickener of preferably from about 0.1% to about 2%, the thickening
Agent includes thickener, gelling agent and structuring agents.Other characteristics according to needed for the compatibility and product with other components
To select the content and classification of thickener.
The non-limiting classification of thickener includes the polypropylene of cross-linked polyacrylate polymer and copolymer, hydrophobically modified
Acid ester polymer and copolymer, polyacrylamide polymers and copolymer, polypropylene acyl group dimethyltaurate, amino methyl
Propyl alcohol (AMP)-base polymer and copolymer, polysaccharide and natural gum.For use in the present invention is carboxylic acid/carboxylate copolymer.It can
Carboxylic acid/carboxylate copolymer non-limiting example for this paper includes: trade name Pemulen TR-1, Pemulen TR-
2、Carbopol Ultrez 10、Carbopol Ultrez 20、Carbopol Ultrez 21、Carbopol 1342、
The CTFA title acrylate of Carbopol 1382 and Carbopol ETD2020/acrylic acid C10-30 alkyi acrylate cross polymerization
Object (derives from Noveon).The commercially available additional water-soluble polymer for being highly available for this paper includes trade name
The xanthan gum of KELTROL series derives from CP Kelco；Trade name Carbopol 934, Carbopol 940, Carbopol
950, the carbomer (deriving from Noveon) of Carbopol 980 and Carbopol 981；The propylene of trade name ACRYSOL 22
- 20 methacrylate copolymer of acid esters/steareth (derives from (Rohm&Hass)；With trade name SEPIGEL
Series polyacrylamide or polyacrylate/salt, trade name SEPIGEL 305, SEPIGEL EG, SEPIGEL NS,
SEPIGEL FL, SEPIGEL INS100, SEPIPLUS 400, SEPINOV EMT10 (deriving from SEPPIC)；Trade name
The polyglycerolmethacrylate and trade name LUBRAGEL OIL of LUBRAGEL NP, polyglycerolmethacrylate,
The mixture (deriving from ASHLAND) of propylene glycol and Gantrez AN-119；Trade name CARBOWAX PEGs, POLYOX WSRs
With UCON FLUIDS based on ethylene oxide and/or epoxypropane polymer (deriving from DOW CHEMICAL).
Another kind of thickener includes structuring agents.The non-limiting example of structuring agents includes the C12-C30 of saturation
Fatty alcohol, the C12-C30 fatty alcohol of the saturation comprising about 1 to about 5 moles of ethylene oxide, the C12-C30 glycerol monoethers of saturation are satisfied
The C12-C30 monoglyceride and their mixture of sum, at least about 40 DEG C of the fusing point having.Currently preferred structure
Change reagent selected from consisting of the following group: stearyl alcohol, cetanol, docosanol, glyceryl monostearate.
Emulsifier
Skin nursing products of the invention may include emulsifier, for mutually dispersing oil and being suspended in the aqueous phase
In.When skin nursing products of the invention include emulsifier, it includes be no more than 10%, preferably more than 5%, and more excellent
Choosing is no more than 3% emulsifier.
Numerous emulsifiers can be used for herein.In one embodiment, the non-limiting example of emulsifier includes nonionic
With anion emulsifier such as sugar ester and polyester, alkoxylated sugar esters and polyester, C1-C30 fatty alcohol C1-C30 aliphatic ester,
The alkoxy derivative of C1-C30 aliphatic ester, the alkoxylated ether of C1-C30 fatty alcohol, the C1-C30 of C1-C30 fatty alcohol
The polyglycereol base ester of fatty acid, the C1-C30 ester of polyol, the C1-C30 ether of polyol, alkyl phosphate,
Polyoxyalkylene fatty ether phosphate, fatty acid amide, acyl lactylates soap and their mixture.
The non-limiting embodiment that can be used for other emulsifiers of this paper includes: polyethylene glycol 20, the sorbitan-moon
Cinnamic acid ester (polysorbate 20), steareth -20, cetearyl polyoxyethylene ether -20, PPG- methyl glucose
Sugar ether distearate, cetyl polyoxyethylene ether -10, polysorbate 80, cetyl phosphate, cetyl phosphate potassium,
Cetyl phosphate diethanol amine, polysorbate 60, tristerin, PEG-100 stearate, polyoxyethylene 20 are dehydrated mountain
Pears sugar alcohol trioleate (polysorbate 85), sorbitan-laurate, 4 lauryl ether odium stearate of polyoxyethylene,
- 4 isostearate of polyglyceryl, lauric acid hexyl ester, PPG- methyl glucose ether distearate, cetyl polyoxyethylene
Ether -10, cetyl phosphate diethanol amine, Cremophor RH40, PEG-60 rilanit special, glycerin polyether -25PCA are different hard
Resin acid ester and their mixture.
In another embodiment, the emulsifier is silicone emulsifiers, including organically-modified organic poly- silicon oxygen
Alkane (silicone surfactant), such as dimethicone copolyol.
Osamine
Skin nursing products of the invention may include the osamine of safe and effective amount, be also known as amino sugar.As used herein,
" osamine " refers to the amine derivative of hexose.The composition preferably comprises by weight of the composition about 0.001% to about
20%, preferably from about 1% to about 10%, the osamine of even more preferably about 2% to about 5%.The example of osamine for use in the present invention
Including aminoglucose, N- acetyl glucosamine, mannosamine, N- acetyl mannosamine, galactosamine, N- acetyl galactose
Amine.May be preferably used for this paper is aminoglucose.In addition, it is possible to use the combination of two or more osamines.
Sun-screening agent
Skin nursing products of the invention may include one or more sunscreen actives (or " sun-screening agent ") and/or ultraviolet
Light absorbers." sunscreen actives " include sun-screening agent and physical sunscreen frost herein.Sunscreen actives substance and ultraviolet radiation absorption
It can be organic or inorganic.
Supplementary element
Suitable wetting agent includes but is not limited to polyalcohol, such as polyalkylene glycol and their derivative.Illustratively
Be propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbierite, hexylene glycol, 1,3 butylene glycol, ethoxylation it is sweet
Oily, propenoxylated glycerol and their mixture.
Suitable emollient includes but is not limited to hydrocarbon, fatty acid, fatty alcohol and ester.
Suitable non-vitamin antioxidant and free radical scavenger include but is not limited to BHT (butylated hydroxyl first
Benzene), L- erythrothioneine (using TH work OTANETM as trade name), tetrahydro curcumin, Aden's perfume base malonic acid ethylhexyl (with
OXYNETM is trade name), (octadecene diacid, ARLATONETM DioicDCA, derive from 18 carbon -8- alkene -1,16- dicarboxylic acids
CROAD), ubiquinone (Co-Q10), tea extract including green-tea extract and their combination.
Suitable phytosterol and/or plant hormone example includes but is not limited to sitosterol, stigmasterol, campesterol, rue
Tongue fur sterol.
Suitable anti-inflammatory agent includes but is not limited to glycyrrhizic acid (being also known as glycyrrhizin, glycyrrhizic acid and glycyrrhizic acid), Radix Glycyrrhizae
Pavilion acid, other licorices and their combination.
Other available skin care actives include moisturizing and/or conditioner, such as hydrolyze heartsease extract, with
Aquaphyline derives from Silab；Rhamnose is releived agent, derives from sethic with RHAMNOSOFT；Glycine betaine, with Tego
Natural Betaine derives from EVONIK；Sarcosine, skin lightening agent such as kojic acid, mulberry extract, arbutin, seaweed glue, aloe mention
Take object, aloe powder and their mixture.
When using, the skin care compositions and methods containing yeast extract are preferably comprised based on the weight of composition about
0.01% to about 10%, more preferably from about 2% to 5%.
The composition can further include at least one compound, and the compound is selected from consisting of the following group: shield
Skin active material, sun-screening agent, wetting agent and emollient.
Skin nursing products preparation
The skin nursing products of local use of the invention can be configured to skin of face cosmetics, eye cosmetic, skin
Facial mask, skin creams, skin gel, eye gel, eye cream, lip gel, lip frost, cosmetics, foundation cream or any other commonly known
Skin nursing products.
The present invention has following advantageous effects:
1, a kind of skin care compositions and methods containing yeast extract of the present invention, contain yeast extract, polypeptide, iron simultaneously
Skin Herba Dendrobii extract and several mineral materials can not only keep the skin health colour of skin, but also have desalination wrinkle, repair skin barrier function
Can, make skin health, call forth one's youthful vigor.
2, additional beneficial effect can also be provided in composition of the invention, and the additional beneficial effect includes stability, without aobvious
Write (consumer is unacceptable) skin irritation and good aesthetic.
Detailed description of the invention
Fig. 1 is wrinkle number reduction amount before and after volunteer's use.
Specific embodiment
Below by way of specific preferred embodiment combination compliance test result test example content, the present invention is made further specifically
It is bright, but the present invention is not limited in embodiment below.
Embodiment 1 to 8 represents the non-limiting example of skin care compositions and methods as described herein, according to described herein
Method is suitble to be coated on collenchyme.The composition is suitable for following preparation:
Embodiment 1-4
Skin shield product (essence/gelled composition) constitutive material and weight percent content of embodiment 1-4 is as follows
Shown in table 1.
The raw material of the skin nursing products (essence/gelled composition) of 1 embodiment 1-4 of table forms
* 1, acrylate copolymer Carbopol 940: Noveon is derived from；
* 2, acrylate copolymer UltreZ21: Noveon is derived from；
* 3, KELTROL CG-T: CP Kelco is derived from；
* 4 Pemulen TR-2: Noveon is derived from；
* 5 LUBRAGEL OIL: ISP is derived from；
* 6 hyaluronic acids: Shandong Fu Ruida is derived from；
* 7 dipotassium glycyrrhizinates: general plant medicine company is derived from；
* 8 OKINACEA: GELYMA is derived from；
* 9 glycine betaines: EVONIK is derived from；
* 10 PE9010: Shu Mei company of Germany is derived from；
C phase constituent-skin care compositions and methods therein, raw material components formula and parts by weight content are as shown in table 2 below.
The raw material components formula of 2 skin care compositions and methods of table
| Ingredient names | Content (parts by weight) |
| Yeast extract | 5 parts |
| Minerals | 2 parts |
| Peptide (lx10-5The aqueous solution of % concentration) | 2 parts |
| Dendrobium candidum extract (10% aqueous solution) | 1 part |
| Niacinamide | 2 parts |
| Water | 88 parts |
Wherein, the process for making of skin care compositions and methods is as follows:
1) preparation of dendrobium candidum aqueous solution:
Dendrobium candidum Dendrobium candidum 100g is taken, 9 times of amount deionized waters are added, after crushing crusher machine, filter
It crosses, extract obtained manufactured solution obtains the dendrobium candidum extracting solution of content 10%.
2) yeast extract, minerals, peptide, dendrobium candidum extract, niacinamide are sequentially added in agitated kettle, addition is gone
Ionized water, mending to weight ratio is 100%, opens stirring 30 minutes to 1 hour, until all materials are sufficiently mixed uniformly, stops stirring
It mixes, it is spare.
Embodiment 1 to 4 provides essence/gelled composition, and is suitable for that following processing step is prepared:
1) A phase: use suitable blender (such as anchor formula agitating paddle, propeller or work KAT25) by all ingredients
It mixes in a reservoir, is heated to 80 ± 2 DEG C, insulated and stirred is until the phase uniforms；
2) B phase component is successively added to A phase, is kept for 80 ± 2 DEG C of temperature, insulated and stirred is until the phase uniforms；
3) cooling water is opened, C phase materials are added to 45 DEG C in cooling material, and mix until homogenization；
4) cooling material samples inspection to 40 DEG C.After the assay was approved, stop stirring, discharging.
Skin shield product (lotion/gel cream composition) constitutive material and weight percent content of embodiment 5-8 is as follows
Shown in table 3.
The raw material of the skin nursing products (lotion/gel cream composition) of 3 embodiment 5-8 of table forms
* 1 ALGISIUM C derives from EXSYMOL
* 2 Lecinol S-10 derive from NIKKOL
* 3 Brij 721 derive from CRODA
* 4 SIMULSOL 165 derive from SEPPIC
* 5 ABIL Care 85 derive from EVONIK
* 6 MONTANOV L derive from SEPPIC
* 7 TEGOSOFT CT derive from EVONIK
* 8 Plandool-G derive from Nippon Seika K.K.
* 9 LANOL 99 derive from SEPPIC
* 10 DC200 100cst derive from Dow Corning Corp
* 11 SILSOFT 034 derive from MOMENTIVE
* 12 DC 9040 derive from Dow Corning Corp
* 13 De Minshu derive from Symrise
* 14 rhamnoses are releived agent, Sethic is derived from
D phase supplementary element therein: skin care compositions and methods, raw material components formula and content are as shown in table 4 below.
The raw material components formula of 4 skin care compositions and methods of table
| Ingredient names | Content (parts by weight) |
| Yeast extract | 5 parts |
| Minerals | 2 parts |
| Peptide (lx10-5The aqueous solution of % concentration) | 5 parts |
| Dendrobium candidum extract (10% aqueous solution) | 10 parts |
| Niacinamide | 3 parts |
| Water | 75 parts |
Wherein, the process for making of skin care compositions and methods is as follows:
1) preparation of dendrobium candidum aqueous solution:
Dendrobium candidum Dendrobium candidum 100g is taken, 9 times of amount deionized waters are added, after crushing crusher machine, filter
It crosses, extract obtained manufactured solution obtains the dendrobium candidum extracting solution of content 10%.
2) yeast extract, minerals, peptide, dendrobium candidum extract, niacinamide are sequentially added in agitated kettle, addition is gone
Ionized water opens stirring 30 minutes to 1 hour, until all materials are sufficiently mixed uniformly, stops stirring, spare.
Embodiment 5 to 8 provides lotion/gel cream composition, and is suitable for that following processing step is prepared:
1) A phase: suitable blender (such as anchor formula agitating paddle is used！Propeller or work KAT25) by all ingredients
It mixes in a reservoir, is heated to 80 ± 2 DEG C, insulated and stirred is until the phase uniforms.
2) B phase: suitable blender (such as anchor formula agitating paddle is used！Propeller or work KAT25) by all ingredients
It mixes in a reservoir, is heated to 80 ± 2 DEG C, insulated and stirred is until the phase uniforms.
3) slowly B is added in A phase, mixing is until batch of material uniforms, and emulsifying 8 minutes, insulated and stirred 10 was divided
Zhong Hou opens cooling water, side stirring cooling；
4) C phase materials are added to 60 DEG C in cooling material, and mix until homogenization；
5) continue cooling material to 45 DEG C, sequentially add D phase materials and mix, until material homogenization；
6) cooling material samples inspection to 40 DEG C.After the assay was approved, stop stirring, discharging.
Effect application test example
1, improve facial skin performance evaluation:
Test method:
Volunteer's selection: men and women has, and 25~45 years old, health, no skin disease and allergies, non-sensitive skin, state
Degree is conscientious, can be by Normalization rule cosmetics, and cooperating personnel complete appraisal as required, has certain statement energy
Power, the impression after energy actual response use.
Volunteer's number: 20 people
Evaluation index: facial skin elasticity, skin shine, eye circumference wrinkle quantity
Test zone: face, including canthus, now, cheek region
Test period: 8 weeks
(1), skin elasticity is tested: skin elasticity is also the one of the important signs that for judging skin aging, carries out skin elasticity survey
It surely is that skin aging detects essential project.
Principle: using MPA580 elasticity tester, is investigated by the size of the reply deformation of test skin and uses cosmetics
The senile-resistant efficacy of cosmetics is evaluated in the variation of skin elasticity afterwards.
By using embodiment 1 to 8 and placebo respectively to above 20 people, skin elasticity is tested, it will be real
Data analysis summary is tested to be as follows:
5 skin elasticity of table improves situation table
Analysis of conclusion: it can be seen that using the embodiment of skin care compositions and methods by the above experimental data to skin elasticity
It improving significantly, dosage is bigger, and effect is more significant, it is more obvious using time longer effect, after 8 weeks, maximum skin bullet
Property degree of improvement be 32.5%.
(2), wrinkle is tested
Wrinkle formation is the most important feature of skin aging, the shadow changed by many endogenous factors such as heredity, endocrine
It rings, while extrinsic factor such as ultraviolet light, smoking etc. can formation that is significantly accelerated, aggravating wrinkle.Wrinkle be skin aging most
First sign.Wrinkle further develops, and will form pleat, i.e. pleat deeper on skin.The sequence of appearance be usually forehead, up and down
Eyelid, paropia, mouth week.In general, after 25 years old, the ageing process of skin starts, and wrinkle occurs gradually.Human body frons
May occur in which wrinkle, 30~40 years old when, is increasing and by deepening to aggravate, while crow's feet occurs in tail of the eye portion, to 50 years old with
Afterwards, deep wrinkles occur, and form more typical aging appearance.The measurement for carrying out wrinkle of skin, for judging skin aging ten
Divide important.
Experimental method: choosing 10 individuals for having an obvious wrinkle, using the product containing skin care compositions and methods, and to using
It is preceding and observe skin nursing group using the variation of carry out taking pictures the after a certain period of time number and the wrinkle depth that compare wrinkle quantity
Close the anti-crape effect of object.
Can be seen that skin care compositions and methods by several groups of pictures has obviously the number and the wrinkle depth of wrinkle quantity
Improvement result.It is as shown in table 6 below before and after specific wrinkle number situation use.
Unit the case where trier's wrinkle number before and after table 6 is on probation: item
Illustrated by Fig. 1 and table 6, skin care compositions and methods can be widely used for facial skin to wrinkle of skin significant effect is improved
In skin skin care products.
2, human skin stimulation test:
Following experiments have been carried out to the skin care compositions and methods；
Acute skin irritation test: nonirritant
Acute ocular irritation test: nonirritant
Oral toxicity test: LD50 takes orally (50) and is no less than 15ml/kg
Accumulation uses test: erythema and oedema is not observed within continuous 14 days
Cutaneous sensibility test: erythema and oedema is not observed
Skin phototoxicity test: erythema and oedema is not observed
Photosensitivity test: erythema and oedema is not observed
Human body patch test: after application after 48 hours, the no negative reaction of all 20 aspirations
The above experimental data explanation, skin care compositions and methods are safe.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
Without departing from the technical solutions of the present invention, to the above embodiments according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (11)
1. a kind of skin care compositions and methods containing yeast extract, it is characterised in that: each raw material group comprising following parts by weight
Point:
5-20 parts of yeast extract；The yeast extract is that yeast will wherein protein, nucleic acid, dimension life after broken wall
Element extracting, then the substance of the amino acid rich in small molecule through biological enzymolysis, peptide, nucleotide, vitamin active skull cap components；
0.1-5 parts of minerals；The minerals are commercial product Biomin Marine Acqua-Biomins system
One of column or SEPITONIC M3 or a variety of combinations；
lx10-55-25 parts of the peptide of the aqueous solution of % concentration；The peptide include dipeptides, tripeptides, tetrapeptide, pentapeptide and hexapeptide and they
Derivative；
5-10 parts of dendrobium candidum extract；The dendrobium candidum extract is the aqueous solution for the Dendrobium officinale polysaccharide that self-control contains 2%；
0.1-5 parts of niacinamide；
45-85 parts of water.
2. the skin care compositions and methods according to claim 1 containing yeast extract, it is characterised in that:
30% or more amino acid content in the yeast extract, 50% or more total protein, 10% or more nucleotide, yeast extract
5-10 parts of object；
Described minerals 1-3 parts；
5-8 parts of dendrobium candidum extract；
2-3 parts of niacinamide.
3. the skin care compositions and methods according to claim 1 containing yeast extract, it is characterised in that: be by the following method
Step preparation:
1) dendrobium candidum aqueous solution is prepared, includes following technique:
Dendrobium candidum 100g is taken, 9 times of amount deionized waters are added, after crushing crusher machine, filtration, extract obtained manufactured solution,
Obtain the dendrobium candidum extracting solution A of content 10%；
2) yeast extract, minerals, peptide, dendrobium candidum extract, niacinamide are sequentially added in agitated kettle, deionization is added
Water opens stirring 30 minutes to 1 hour, until all materials are sufficiently mixed uniformly, stops stirring, spare.
4. a kind of skin nursing products, it is characterised in that: it contains skin nursing group as claimed in any one of claims 1-3
Object is closed, which accounts for the 0.01% to 10% of skin nursing products total amount；The skin nursing products also include such as
The each raw material component of lower weight percent:
0.1% to 40% oily phase；
60% to 98% aqueous phase；
0.01% to 2% pH adjusting agent；
The emulsifier of 3%-10%；
0.001% to 20% osamine；
0.1% to 20% other compositions.
5. skin nursing products according to claim 4, it is characterised in that: the skin care compositions and methods account for skin nursing production
The 2% to 5% of product total amount.
6. skin nursing products according to claim 4, it is characterised in that:
The oil be mutually considered not with it is aqueous miscible, and selected from one of natural and synthetic oil, oil-soluble sun screens or more
Kind；
The aqueous phase accounts for the 65% to 95% of total composition；The aqueous phase includes aqueous carrier and thickener.
7. skin nursing products according to claim 6, it is characterised in that: the aqueous carrier includes water and low alkyl group
The aqueous solution of alcohol；The lower alkyl alcohol is the monohydric alcohol with 1 to 6 carbon atom.
8. skin nursing products according to claim 6, it is characterised in that: the aqueous phase is selected from 0.1% to 3% increasing
Thick dose.
9. skin nursing products according to claim 4, it is characterised in that: the composition includes based on the weight of composition
2% to 5% osamine.
10. skin nursing products according to claim 4, it is characterised in that: the other compositions are selected from moisturizer, moisturizing
Agent, non-vitamin antioxidant, suitable phytosterol and/or plant hormone, anti-inflammatory agent and their combination.
11. skin nursing products according to claim 4, it is characterised in that: be prepared by following processing step:
1) the water-soluble component of A phase: all ingredients are mixed in a reservoir using suitable blender, are heated to 80 ± 2 DEG C, are protected
Temperature stirring is until the phase uniforms；The blender is anchor formula agitating paddle or propeller；
2) B phase oil-soluble component is successively added to the water-soluble component of A phase, is kept for 80 ± 2 DEG C of temperature, insulated and stirred is until described
Mutually uniform；
3) cooling water is opened, remaining component material of C phase is added to 45 DEG C in cooling material, and mixes until homogenization；
4) cooling material samples inspection to 40 DEG C；After the assay was approved, stop stirring, discharging.
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| CN106265479A (en) * | 2016-10-27 | 2017-01-04 | 广州仙施生物科技有限公司 | A kind of skin repair compositions and preparation method thereof |
| CN107693779B (en) * | 2017-05-10 | 2021-04-27 | 广州润虹医药科技股份有限公司 | Scar-removing composition and preparation method thereof |
| EP3641725A1 (en) | 2017-06-23 | 2020-04-29 | The Procter and Gamble Company | Composition and method for improving the appearance of skin |
| CN111278326A (en) * | 2017-07-28 | 2020-06-12 | 轨迹Ip有限责任公司 | Yeast-based mask for improving skin, hair and scalp health |
| KR102126469B1 (en) * | 2017-09-04 | 2020-06-24 | 주식회사 엘지생활건강 | Cosmetic Compositions comprising extract of Dendrobium candidum flower extract |
| CN107822945A (en) * | 2017-09-28 | 2018-03-23 | 杭州惠博士健康产业有限公司 | One kind is matched unartificial yeast composition, preparation method and applied in cosmetics |
| CN107898754A (en) * | 2017-12-13 | 2018-04-13 | 上海拉丽丝商贸有限公司 | The composition of one primary yeast extractive from fermentative and its application in cosmetics |
| WO2020010036A1 (en) | 2018-07-03 | 2020-01-09 | The Procter & Gamble Company | Method of treating a skin condition |
| CN110812317A (en) * | 2019-12-20 | 2020-02-21 | 北京美丽年华文化有限公司 | Skin care product with effects of moisturizing epidermis and resisting wrinkles of skin and preparation method thereof |
| CN111214418A (en) * | 2020-03-13 | 2020-06-02 | 佛山市奥姿美生物科技有限公司 | Efficient barrier repair composition and application thereof |
| CN115843238A (en) | 2020-06-01 | 2023-03-24 | 宝洁公司 | Method for improving penetration of vitamin b3 compounds into the skin |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| CN116445306B (en) * | 2023-06-15 | 2023-09-01 | 山东锦鲤生物工程有限公司 | Schizosaccharomyces pombe and its application in improving skin condition |
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Effective date of registration: 20221024 Address after: 515834 Liannan Industrial Zone, Chenghai District, Shantou City, Guangdong Province Patentee after: Guangdong Mingchen Daily Chemical Co.,Ltd. Address before: 515834 Liannan Industrial Zone, Lianxia Town, Chenghai District, Shantou City, Guangdong Province Patentee before: MINGCHEN HEALTH Co.,Ltd. |