CN105586258B - Magnetic absorption transferring stick - Google Patents
Magnetic absorption transferring stick Download PDFInfo
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- CN105586258B CN105586258B CN201610142513.5A CN201610142513A CN105586258B CN 105586258 B CN105586258 B CN 105586258B CN 201610142513 A CN201610142513 A CN 201610142513A CN 105586258 B CN105586258 B CN 105586258B
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- magnet
- pull rod
- vessel
- adsorption tube
- box body
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
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Abstract
The present invention relates to a kind of magnetic absorption transferring sticks, it includes adsorption tube, the magnet being arranged in adsorption tube and the draw-out device that will be extracted out out of adsorption tube after magnet shield, absorption pipe outer wall are equipped with adsorption plane, vessel are equipped in adsorption tube, vessel is equipped with open end and blind end, and magnet is arranged in vessel；The magnet is formed by two pieces or more of neodymium iron boron array, and antifreeze plate is equipped between adjacent two pieces of neodymium iron borons.Such magnetic absorption large knitting needle is set to being attached with the cell of magnetic nano-particle, after being adsorbed with the cell of magnetic nano-particle, passes through the shielding transfer to magnet so that the cell on adsorption plane is adsorbed by the magnetic field of another addition, convenient for detection observation.
Description
Technical field
The present invention relates to a kind of utensil biologically applied, especially one kind be mainly used for medically shifting carrying magnetic it is thin
Born of the same parents, blood equal samples magnetic absorption transferring stick.
Background technology
Chinese Patent Application No. 201210389753.7 disclosed rare cell in a kind of blood on 2 6th, 2013
Separator, including microchip and its attached peripheral equipment, including memory and pump；Microchip includes having reeded thin slice and load
Slide, thin slice are placed on one microfluidic channel of formation on glass slide；The microfluidic channel be connected to the memory and the pump it
Between, allow the blood sample from memory stream to pump；Multiple magnet are located at by the glass slide, and ladder is formed along the length of glass slide
The Distribution of Magnetic Field of degree, glass slide are used for acquiring rare cell；Magnetic nano-particle, magnetic nano-particle are put into blood sample
Surface carries antibody, is adsorbed on target cell by immune response, then sets the blood sample that rare cell has been labeled
It is put into memory, after pump startup, when blood sample passes through microfluidic channel, magnetic nano-particle is attached in blood sample
Rare cell can be attracted by magnet.The structure medically still if necessary will be attached with the progress on definite meaning
The rare cell for the nano-particle that is magnetic is shifted, then is operated cumbersome.It is therefore desirable to design a absorption migration dress
It sets, in order to shift the cell for being attached with magnetic nano-particle, carries out subsequent operation.
Invention content
The purpose of the present invention is to provide a kind of reasonable for structure, easy to operate, safety and sanitation, reliable operation magnetic absorption
Transferring stick, with overcome the deficiencies in the prior art.
The object of the present invention is achieved like this：
A kind of magnetic absorption transferring stick, it is characterised in that：Including adsorption tube, the magnet being arranged in adsorption tube and by magnet
The draw-out device extracted out out of adsorption tube after shielding, absorption pipe outer wall are equipped with adsorption plane, are equipped with vessel in adsorption tube, vessel is equipped with
Open end and blind end, magnet are arranged in vessel；The magnet is formed by two pieces or more of neodymium iron boron array, adjacent two pieces of neodymiums
Antifreeze plate is equipped between iron boron.
The purpose of the present invention can also use following technical measures to solve：
As more specific scheme, in a rectangular parallelepiped shape, the magnetizing direction of neodymium iron boron is perpendicular to adsorption plane, phase for the neodymium iron boron
The NS magnetic directions of adjacent two pieces of neodymium iron borons are opposite.
The neodymium iron boron is equipped with two to ten pieces, each linear array arrangement of neodymium iron boron so that and entire magnet is in strip, and
And because magnet is made of polylith neodymium iron boron, magnet forms magnetic field along its array direction.
Adsorption tube is the tube body made of saturating material.When adsorption tube is put into another magnetic field parallel with adsorption plane, simultaneously
And when removing intracavitary magnet, the quantity of magnetic cell can be counted from the polishing of the adsorption tube back side.Certainly, the material of adsorption tube
Material is preferably the translucent material of pure color.
As further embodiment, the draw-out device includes shielding box and pull rod, and the appearance in adsorption tube is arranged in shielding box
Intracavitary, pull rod one end is stretched into from the open end of vessel in vessel to connect with shielding box；Shielding box is made of box body and box cover, box body
Respective magnet is equipped with groove, and for groove tool there are one open surface, the other faces of groove are ground plane, and magnet is arranged in groove；Box cover
It is connect with pull rod and it is controlled by pull rod and open and close the open surface of box body；When box cover closes open surface, pull rod is solid with box body
Fixed connection, and/or, box cover is fixedly connected with box body.When the lid is closed, pull rod can be by the magnet of shielding box and Qi Nei together
Pull away adsorption tube.
The adsorption plane is plane, the open surface of adsorption plane face box body.When magnet is shielded or detaches adsorption plane,
The substance adsorbed is fixed by other magnetic fields separately added.
The open surface of the box cover and box body is slidably matched along vessel axis direction, and box cover one end is detained with described pull rod one end
It connects.
The box body is equipped with button bit towards one end of pull rod, and described pull rod one end corresponds to button bit and is equipped with overhead kick, overhead kick and button
Position snapping.
As further scheme, the box body is equipped with pilot pin towards one end of pull rod, and positioning wire surface, which is equipped with, is in
The button bit of annular groove shape, described pull rod one end correspond to pilot pin and are equipped with positioning jack, and positioning jack is towards pilot pin
It is laid with more than two overhead kicks outside port, forms resilient slotted between overhead kick and overhead kick, overhead kick is externally provided with necking down position,
Box cover one end corresponds to necking down position and is equipped with buckle, buckle and necking down position snapping.
The other end of the pull rod is equipped with hand handle, and the vessel open end of adsorption tube is externally provided with fixed ear and muscle piece.Fixed ear
Fixed and reinforcement structure effect is each served as with muscle piece.
Beneficial effects of the present invention are as follows：
Such magnetic absorption large knitting needle is set to being attached with the cell of magnetic nano-particle, is adsorbed with magnetic nano-particle
Cell after, pass through and the shielding of magnet shifted so that the cell on adsorption plane is adsorbed by the magnetic field of another addition, convenient for detection
Observation.
Description of the drawings
Fig. 1 is one embodiment of the invention decomposition texture schematic diagram.
Fig. 2 is structural schematic diagram after Fig. 1 assembly.
Fig. 3 is enlarged structure schematic diagram at A in Fig. 1.
Fig. 4 is present invention looks up structural representation of the present invention.
Fig. 5 is the D of Fig. 4 to face structural schematic diagram.
Fig. 6 is the B-B section views of Fig. 5（Box cover opening state）Structural schematic diagram.
Fig. 7 is the box cover closed state structural schematic diagram of Fig. 6.
Fig. 8 is enlarged structure schematic diagram at C in Fig. 7.
Fig. 9 is that magnet extracts status architecture schematic diagram out in Fig. 7.
Specific implementation mode
The invention will be further described with reference to the accompanying drawings and embodiments.
Shown in Fig. 1 to Fig. 5 and Fig. 8, a kind of magnetic absorption transferring stick, including adsorption tube 1, setting are in adsorption tube 1
Interior magnet and the draw-out device 10 that will be extracted out out of adsorption tube 1 after magnet shield, 1 outer wall of adsorption tube are equipped with adsorption plane 11, inhale
Vessel 13 is equipped in attached pipe 1, vessel 13 is equipped with open end and blind end, and magnet is arranged in vessel 13；The magnet is by two pieces
Above 5 array of neodymium iron boron forms, and antifreeze plate 6 is equipped between adjacent two pieces of neodymium iron borons 5.
The adsorption tube 1 is the tube body made of saturating material.
The neodymium iron boron 5 in a rectangular parallelepiped shape, the magnetizing direction of neodymium iron boron 5 perpendicular to adsorption plane, adjacent two pieces of neodymium iron borons
NS magnetic directions are opposite.
The neodymium iron boron 5 is equipped with two to ten pieces（It is seven pieces in the present embodiment）, 5 linear array of each neodymium iron boron arrangement.
The draw-out device 10 includes shielding box and pull rod 2, and shielding box is arranged in the vessel 13 of adsorption tube 1, pull rod 2 one
End is stretched into from the open end of vessel 13 in vessel 13 to connect with shielding box；Shielding box is made of box body 4 and box cover 3, and box body 4 corresponds to
Magnet is equipped with groove 43, and for the tool of groove 43 there are one open surface, 43 other faces of groove are ground plane, and magnet is arranged in groove 43；
Box cover 3, which connect with pull rod 2 and controls it by pull rod 2, opens and closes the open surface of box body 4, when box cover 3 closes open surface, draws
Bar 2 is fixedly connected with box body 4.
The adsorption plane 11 is plane, the open surface of 11 face box body 4 of adsorption plane.
The box cover 3 and the open surface of box body 4 are slidably matched along 13 axis direction of vessel, 3 one end of box cover and the pull rod 2
One end snapping.
The box body 4 is equipped with button bit 42 towards one end of pull rod 2, and 2 one end of the pull rod corresponds to button bit 42 and is equipped with overhead kick 23,
Overhead kick 23 and 42 snapping of button bit.
The box body 4 is equipped with pilot pin 41 towards one end of pull rod 2, and 41 surface of pilot pin is equipped with the institute of groove-like in a ring
State button bit 42,2 one end of the pull rod corresponds to pilot pin 41 and is equipped with positioning jack 22, and positioning jack 22 is towards the port of pilot pin 41
Three overhead kicks 23 are laid with outside, form resilient slotted 24 between overhead kick 23 and overhead kick 23, overhead kick 23 is externally provided with necking down position
231,3 one end of box cover corresponds to necking down position 231 and is equipped with buckle 31, buckle 31 and 231 snapping of necking down position.
The other end of the pull rod 2 is equipped with hand handle 21, and 13 open end of vessel of adsorption tube 1 is externally provided with fixed ear 14 and muscle piece
12。
Above-mentioned antifreeze plate 6, box cover 3 and box body 4 are not necessarily absolute every magnetic, can be with the characteristic of weak magnetic conduction.
Its operation principle is：When magnetic absorption transferring stick is used as absorption material（It refers mainly to be adsorbed with magnetic nano-particle
Cell）When, box cover 3 is opened, moreover, box body 4 pushes in 1 inner cavity 13 of adsorption tube at face adsorption plane 11, due to magnetic in box body 4
Body is not shielded towards the side of adsorption plane 11, so relatively other faces have compared with high-intensity magnetic field, magnetic field can be penetrated to absorption
On face 11, as shown in Figure 6；By adsorption plane 11 on the substance for needing to adsorb, that is, complete absorption.State shown in Fig. 6 is kept again,
Magnetic absorption transferring stick is put into another magnetic field parallel with adsorption plane 11, adsorption tube 1 is fixed, then toward the inner cavity
Pushing drawing rod 2 in 13, pull rod 2 drive box cover 3 to cover box body 4, and magnet is shielded, meanwhile, overhead kick 23 and the box body 4 of pull rod 2
42 snapping of button bit fix, as shown in Figure 7；When user, which needs to pull out magnet from adsorption tube 1, to come, directly in Fig. 7 institutes
Show and continue to pull out pull rod 2 outward under state, as shown in Figure 9.Since adsorption tube 1 is light-transmission tube, from 1 back side polishing of adsorption tube
The quantity of magnetic cell can be counted by coming up.In addition, under normal circumstances, the adsorption tube 1 be it is disposable, magnet and
Draw-out device 10 can then match after leaving adsorption tube 1 with other adsorption tubes.
Claims (6)
1. a kind of magnetic absorption transferring stick, it is characterised in that：Including adsorption tube（1）, be arranged in adsorption tube（1）Interior magnet and general
From adsorption tube after magnet shield（1）The draw-out device of interior extraction（10）, adsorption tube（1）Outer wall is equipped with adsorption plane（11）, adsorption tube
（1）It is interior to be equipped with vessel（13）, vessel（13）Equipped with open end and blind end, magnet is arranged in vessel（13）It is interior；The magnet by
Two pieces or more of neodymium iron boron（5）Array forms, adjacent two pieces of neodymium iron borons（5）Between be equipped with antifreeze plate（6）；
The draw-out device（10）Including shielding box and pull rod（2）, shielding box setting is in adsorption tube（1）Vessel（13）It is interior, it draws
Bar（2）One end is from vessel（13）Open end stretch into vessel（13）It is interior to connect with shielding box；Shielding box is by box body（4）And box cover
（3）It constitutes, box body（4）Respective magnet is equipped with groove（43）, groove（43）There are one open surface, grooves for tool（43）Other faces are screen
Lee-side, magnet are arranged in groove（43）It is interior；Box cover（3）With pull rod（2）It connects and by pull rod（2）It controls it and opens and closes box
Body（4）Open surface；Box cover（3）When closing open surface, pull rod（2）With box body（4）It is fixedly connected, and/or, box cover（3）With box
Body（4）It is fixedly connected；
The adsorption plane（11）For plane, adsorption plane（11）Face box body（4）Open surface；
The adsorption tube（1）For the tube body made of translucent material；
The box cover（3）With box body（4）Open surface along vessel（13）Axis direction is slidably matched, box cover（3）One end with it is described
Pull rod（2）One end snapping.
2. magnetic absorption transferring stick according to claim 1, which is characterized in that the neodymium iron boron（5）In a rectangular parallelepiped shape, neodymium iron
Boron（5）Magnetizing direction perpendicular to adsorption plane（11）, adjacent two pieces of neodymium iron borons（5）NS magnetic directions it is opposite.
3. magnetic absorption transferring stick according to claim 1 or claim 2, which is characterized in that the neodymium iron boron（5）Equipped with two to ten
Block, each neodymium iron boron（5）Linear array arrangement.
4. magnetic absorption transferring stick according to claim 1, which is characterized in that the box body（4）Towards pull rod（2）One end
Equipped with button bit（42）, the pull rod（2）One end corresponds to button bit（42）Equipped with overhead kick（23）, overhead kick（23）With button bit（42）Snapping.
5. magnetic absorption transferring stick according to claim 4, which is characterized in that the box body（4）Towards pull rod（2）One end
Equipped with pilot pin（41）, pilot pin（41）Surface is equipped with the button bit of groove-like in a ring（42）, the pull rod（2）One end pair
Answer pilot pin（41）Equipped with positioning jack（22）, positioning jack（22）Towards pilot pin（41）Port outside be laid with two with
On the overhead kick（23）, overhead kick（23）With overhead kick（23）Between form resilient slotted（24）, overhead kick（23）It is externally provided with necking down position
（231）, box cover（3）One end corresponds to necking down position（231）Equipped with buckle（31）, buckle（31）With necking down position（231）Snapping.
6. magnetic absorption transferring stick according to claim 5, which is characterized in that the pull rod（2）The other end be equipped with hand handle
（21）, adsorption tube（1）Vessel（13）Open end is externally provided with fixed ear（14）With muscle piece（12）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610142513.5A CN105586258B (en) | 2016-03-14 | 2016-03-14 | Magnetic absorption transferring stick |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610142513.5A CN105586258B (en) | 2016-03-14 | 2016-03-14 | Magnetic absorption transferring stick |
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| Publication Number | Publication Date |
|---|---|
| CN105586258A CN105586258A (en) | 2016-05-18 |
| CN105586258B true CN105586258B (en) | 2018-08-17 |
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| CN201610142513.5A Active CN105586258B (en) | 2016-03-14 | 2016-03-14 | Magnetic absorption transferring stick |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106771307A (en) * | 2017-03-14 | 2017-05-31 | 骏实生物科技(上海)有限公司 | Magnetic analytes collect transfer system and its method |
| SG11202102841WA (en) * | 2018-09-28 | 2021-04-29 | Octane Biotech Inc | Magnetic separation |
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| CN1735806A (en) * | 2002-11-07 | 2006-02-15 | 株式会社三菱化学药得论 | Magnetic material for collecting magnetic particles and utilization thereof |
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| JP2008209330A (en) * | 2007-02-28 | 2008-09-11 | Hitachi High-Technologies Corp | Magnetic separator and analyzing apparatus using the same |
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| CN105586258A (en) | 2016-05-18 |
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Effective date of registration: 20180705 Address after: 528300 three of new hurdle Road, Chen Cun town, Shunde District, Foshan, Guangdong, three Applicant after: Foshan Hui Guang Health Medical Technology Co., Ltd. Address before: 528300 No. 15 North District, Jinlong garden, Chencun Town, Shunde District, Foshan, Guangdong Applicant before: Guo Liangfu |
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Effective date of registration: 20200806 Address after: Plot 2 of xc07-03-02, Xincheng Industrial Park, Xinxing County, Yunfu City, Guangdong Province Patentee after: Baoradar motor (Xinxing) Co., Ltd Address before: 528300 three of new hurdle Road, Chen Cun town, Shunde District, Foshan, Guangdong, three Patentee before: FOSHAN HUIGUANGJIAN MEDICAL TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20211126 Address after: 519000 shop 29, building 1, No. 288, Renmin West Road, Zhuhai, Guangdong Patentee after: ZHUHAI CHENGXING TECHNOLOGY Co.,Ltd. Address before: Plot xc07-03-02, Xincheng Industrial Park, Xincheng Town, Xinxing County, Yunfu City, Guangdong Province Patentee before: Baoradar motor (Xinxing) Co., Ltd |
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