CN105560667A - Orally-taken preparation for treating urticaria and preparation method thereof - Google Patents
Orally-taken preparation for treating urticaria and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an orally-taken preparation for treating urticaria and a preparation method thereof. The orally-taken preparation for treating urticaria is prepared from, by weight, paeonol, lentinan, betulinic acid, tannin, volatile oil, beta-sitosterol, tea saponin, cyproheptadine, flavonoid glycosides, colocasia tonoimo extract, boehmeria siamensis craib extract, lycopodium phlegmaria L. extract, vitamin C and vitamin P. The orally-taken preparation combines western medicine and effective constituents of the traditional Chinese medicine extract, has the effects of dispelling wind, relieving itching, clearing away heat and toxic materials, tonifying the spleen, eliminating dampness and resisting to bacteria, infection and allergy, meanwhile can regulate immunocompetence of the human body and lower the side effects of medicine, can be used for treating urticaria which attacks repeatedly and is remarkable in treatment effect.
Description
Technical field
The present invention relates to urticaria practical technique field, specifically relate to a kind of oral preparations for the treatment of urticaria and preparation method thereof.
Background technology
Dermatosis is one of frequently-occurring disease of puzzlement people ' s health always, it is characterized in that morbidity is light, sickness rate is high, again and again be difficult to radical cure, and relevant with factors such as season, weather, living environment, diet, family histories, pathogenic factor therefore changeable complexity, the patient of 75% even can not find pathogenic factor, to such an extent as to be difficult to radical cure, common as dermatitis, eczema, urticaria, miliaria, tinea manus and pedis etc.Wherein urticaria is common multiple cutaneous disease, it is the allergic disease of a kind of skin allergy, it is a kind of localized edema reaction because skin, the expansion of mucosa thin vessels and permeability increase and occur, usually disappeared in 2 ~ 24 hours, but repeatedly there is new erythra, obstinate and be difficult to cure completely.Usual symptom be pruritus unbearably, and then on skin, there is smooth surface, than surrounding skin dimpling, rubescent or pale welt, when having angioedema symptom, edema scope is large, deeply can reach subcutaneous tissue, involve hands, foot, face or genitals official rank, also may cause other symptoms such as fever, stomachache, diarrhoea.
The treatment of urticaria is to find out the cause of disease thus to eliminate the cause of disease, be equipped with the auxiliary treatment of other symptoms again, but because Most patients is difficult to find out the cause of disease, can only avoid contacting in diet with daily life as far as possible and may produce irritated thing, thus reduce the number of times brought out, and once outbreak generally adopts routine medication, there are medicine for external use and innerlich anwenden, medicine for external use generally can rapid relief of symptoms, but osmotic absorption is slow, cures the symptoms, not the disease; Innerlich anwenden is generally key agents with antihistaminic, it can have contention effect to histamine, thus suppress rapidly the generation of welt, but all there is the large shortcoming of side effect in current antihistaminic, though can symptom management, but can not life-time service, especially chronic urticaria patients and some are had to the people of particular job character.So how to work out one effectively can treat urticaria on the basis of existing medical science, side effect can be dropped to minimum medicine again, be exactly the content that we will study.
Summary of the invention
The technical problem that the present invention solves is, a kind of oral preparations for the treatment of urticaria and preparation method thereof is provided, the oral preparations of this treatment urticaria has that dispelling wind is antipruritic, heat-clearing and toxic substances removing, spleen invigorating dehumidifying, antibacterial, infection, antianaphylactic effect, scalable human body immunity simultaneously, reduce side effect, can be used for the long-term treatment of urticaria.
Technical scheme of the present invention is, treating an oral preparations for urticaria, is be grouped into by the one-tenth of following weight portion: paeonol 10-30 part, lentinan 8-26 part, betulic acid 7.4-25 part, tannin 6-20 part, volatile oil 5.5-18.5 part, cupreol 4-16 part, camellianin 3-15 part, Cyproheptadine 3-14 part, flavonoid glycoside 2-10 part, purple taro extract 0.7-5.3 part, wild Ning nettle extract 0.6-4.2 part, thin fringe Lycopodium clavatum extract 0.4-3.6 part, vitamin C 0.03-0.16 part, Citrin 0.01-0.11 part.
Further, the ratio of described volatile oil to be lactiflorenol and spathulenol with mass ratio be 1.5:2 mixes.
Further, the extracting method of described purple taro extract is: the tuber getting new light violet taro, the soak by water 3-5h of 10-12 times amount is added after smashing to pieces, filter decoction liquor, then the water adding 5-6 times amount in filtering residue continues to decoct 1-2h, filters decoction liquor, merge twice decoction liquor and be condensed into clear paste, carry out spraying dry again, cross 100 mesh sieves, be purple taro extract.Purple taro has mass dissipating and swelling eliminating, the effect of removing toxic substances of dispeling the wind, and its water boiling and extraction thing treatment to urticaria has good effect.
Further, the extracting method of described Ye Ning nettle extract is the dry herbs of: Qu Ye Ning fiber crops, 5min is dried at being placed in dehydrator 50-60 DEG C, pulverize with pulverizer after taking-up, cross 30-50 mesh sieve, the mass concentration adding 7 times amount is the alcoholic solution of 70-82%, supersonic extracting method is used to carry out supersound extraction, arranging ultrasonic power is 310-450W, Extracting temperature is 30-48 DEG C, extraction time is 1.5-2.3h, gained extracting solution is added flocculating agent flocculate with chitosan to filter, vacuum drying is carried out after gained filtrate is concentrated, spraying dry obtains fine powder again, cross 120 mesh sieves, obtain Ye Ning nettle extract.Wild Ning fiber crops have heat-clearing and toxic substances removing, effect that calmness is dispeled the wind, and contained by its ethanol ultrasonic extraction thing, effective ingredient is more, and effect is better.
Further, the extracting method of described thin fringe Lycopodium clavatum extract is: get the thin fringe Lycopodium clavatum herb dried, be placed in dehydrator to dry, arranging bake out temperature is 55-65 DEG C, drying time is 6-8min, coarse powder is ground into disintegrating machine, cross 20-40 mesh sieve, coarse powder is added in Chinese medicine flash extracter, adding 12 times amount mass concentrations is the alcoholic solution of 77-85%, extract four times, each 90 seconds, merge extractive liquid, with the ultrafiltration through membranes that aperture is 0.015-0.021 μm, gained filtrate is concentrated until crystal is separated out, the drying of gained crystal is pulverized with crystal pulverizer afterwards, cross 150 mesh sieves, obtain thin fringe Lycopodium clavatum extract.Thin fringe Lycopodium clavatum extract has the effect of dispelling wind and relieving, removing toxic substances and promoting subsidence of swelling, and the Drug therapy for urticaria has good curative effect.
A kind of preparation method for the treatment of the oral preparations of urticaria is: the paeonol of described composition by weight, lentinan, betulic acid, tannin, cupreol, camellianin, Cyproheptadine, flavonoid glycoside, purple taro extract, Ye Ning nettle extract, thin fringe Lycopodium clavatum extract, vitamin C and Citrin blender are stirred 15min with the rotating speed of 300r/min, gained mixture super micron mill is ground into fine powder, cross 200 mesh sieves, again volatile oil is sprayed directly on fine powder, seal cold preservation after sterilizing, namely obtain the oral preparations of described treatment urticaria.
Further, in described oral preparations, add microcrystalline Cellulose 6-12 part, pregelatinized Starch 5-10 part, carboxymethyl starch sodium 5-9 part, micropowder silica gel 4-9 part, make granule by operations such as mixing, granulation, drying, granulate, subpackages.Microcrystalline Cellulose is filler, has stronger adhesion, is convenient to granulate; Pregelatinized Starch is binding agent, is modified starch, can increase mobility and the compressibility of medicine; Carboxymethyl starch sodium is disintegrating agent, very easily expands after water suction, thus accelerates the dissolving of medicine, is convenient to absorption of human body; Micropowder silica gel is lubricant, has good mobility and tack, is convenient to grain forming.
The invention has the beneficial effects as follows: Western medicine and Chinese medicine extract effective ingredient combine by the present invention, have that dispelling wind is antipruritic, heat-clearing and toxic substances removing, spleen invigorating dehumidifying, antibacterial, infection, antianaphylactic effect, scalable human body immunity simultaneously, reduces side effect, can be used for the long-term treatment of urticaria; Cyproheptadine is antiallergic agent, to the effect of blood vessel, bronchial smooth muscle, thus can eliminate allergic symptom by histamine in antagonist; Paeonol and tannin have the effect of antiallergic action; Lactiflorenol, spathulenol, camellianin and betulic acid have impervious, antibacterial, anti-infective effect; It is antipruritic that purple taro extract, Ye Ning nettle extract and thin fringe Lycopodium clavatum extract have dispelling wind, heat-clearing and toxic substances removing, the effect of mass dissipating and swelling eliminating; Lentinan, cupreol, flavonoid glycoside, vitamin C and Citrin can improve body immunity, enhancing body rehabilitation ability, reduce drug side effect.
Detailed description of the invention
Embodiment 1:
Treating an oral preparations for urticaria, is be grouped into by the one-tenth of following weight portion: paeonol 10 parts, lentinan 8 parts, betulic acid 7.4 parts, tannin 6 parts, volatile oil 5.5 parts, cupreol 4 parts, camellianin 3 parts, Cyproheptadine 3 parts, flavonoid glycoside 2 parts, purple taro extract 0.7 part, wild Ning nettle extract 0.6 part, thin fringe Lycopodium clavatum extract 0.4 part, vitamin C 0.03 part, Citrin 0.01 part.
The preparation method for the treatment of the oral preparations of this urticaria is: by the paeonol of described composition by weight, lentinan, betulic acid, tannin, cupreol, camellianin, Cyproheptadine, flavonoid glycoside, purple taro extract, Ye Ning nettle extract, thin fringe Lycopodium clavatum extract, vitamin C, Citrin is put and is stirred 15min with blender with the rotating speed of 300r/min, gained mixture super micron mill is ground into fine powder, cross 200 mesh sieves, again volatile oil is sprayed directly on fine powder, then microcrystalline Cellulose 6 parts is added, pregelatinized Starch 5 parts, carboxymethyl starch sodium 5 parts, micropowder silica gel 4 parts, by mixing, granulate, dry, granulate, the operations such as subpackage make granule.
Wherein, the ratio of described volatile oil to be lactiflorenol and spathulenol with mass ratio be 1.5:2 mixes, the extracting method of described purple taro extract is: the tuber getting new light violet taro, the soak by water 3h of 10 times amount is added after smashing to pieces, filter decoction liquor, then the water adding 5 times amount in filtering residue continues to decoct 1h, filters decoction liquor, merge twice decoction liquor and be condensed into clear paste, carry out spraying dry again, cross 100 mesh sieves, be purple taro extract, purple taro has mass dissipating and swelling eliminating, the effect of removing toxic substances of dispeling the wind, and its water boiling and extraction thing treatment to urticaria has good effect, the extracting method of described Ye Ning nettle extract is the dry herbs of: Qu Ye Ning fiber crops, 5min is dried at being placed in dehydrator 50 DEG C, pulverize with pulverizer after taking-up, cross 30 mesh sieves, the mass concentration adding 7 times amount is the alcoholic solution of 70%, supersonic extracting method is used to carry out supersound extraction, arranging ultrasonic power is 310W, Extracting temperature is 30 DEG C, extraction time is 1.5h, gained extracting solution is added flocculating agent flocculate with chitosan to filter, vacuum drying is carried out after gained filtrate is concentrated, spraying dry obtains fine powder again, cross 120 mesh sieves, obtain Ye Ning nettle extract, Ye Ning fiber crops have heat-clearing and toxic substances removing, effect that calmness is dispeled the wind, contained by its ethanol ultrasonic extraction thing, effective ingredient is more, effect is better, the extracting method of described thin fringe Lycopodium clavatum extract is: get the thin fringe Lycopodium clavatum herb dried, be placed in dehydrator to dry, arranging bake out temperature is 55 DEG C, drying time is 6min, coarse powder is ground into disintegrating machine, cross 20 mesh sieves, coarse powder is added in Chinese medicine flash extracter, adding 12 times amount mass concentrations is the alcoholic solution of 77%, extract four times, each 90 seconds, merge extractive liquid, with the ultrafiltration through membranes that aperture is 0.015 μm, gained filtrate is concentrated until crystal is separated out, the drying of gained crystal is pulverized with crystal pulverizer afterwards, cross 150 mesh sieves, obtain thin fringe Lycopodium clavatum extract, thin fringe Lycopodium clavatum extract has dispelling wind and relieving, the effect of removing toxic substances and promoting subsidence of swelling, Drug therapy for urticaria has good curative effect, described microcrystalline Cellulose is filler, has stronger adhesion, is convenient to granulate, described pregelatinized Starch is binding agent, is modified starch, can increase mobility and the compressibility of medicine, described carboxymethyl starch sodium is disintegrating agent, very easily expands after water suction, thus accelerates the dissolving of medicine, is convenient to absorption of human body, described micropowder silica gel is lubricant, has good mobility and tack, is convenient to grain forming.
Embodiment 2:
Treating an oral preparations for urticaria, is be grouped into by the one-tenth of following weight portion: paeonol 20 parts, lentinan 17 parts, betulic acid 16.2 parts, tannin 13 parts, volatile oil 12 parts, cupreol 10 parts, camellianin 9 parts, Cyproheptadine 8.5 parts, flavonoid glycoside 6 parts, purple taro extract 3 parts, wild Ning nettle extract 2.4 parts, thin fringe Lycopodium clavatum extract 2.0 parts, vitamin C 0.095 part, Citrin 0.06 part.
The preparation method for the treatment of the oral preparations of this urticaria is: by the paeonol of described composition by weight, lentinan, betulic acid, tannin, cupreol, camellianin, Cyproheptadine, flavonoid glycoside, purple taro extract, Ye Ning nettle extract, thin fringe Lycopodium clavatum extract, vitamin C and Citrin blender stir 15min with the rotating speed of 300r/min, gained mixture super micron mill is ground into fine powder, cross 200 mesh sieves, again volatile oil is sprayed directly on fine powder, then microcrystalline Cellulose 9 parts is added, pregelatinized Starch 7.5 parts, carboxymethyl starch sodium 7 parts, micropowder silica gel 6.5 parts, by mixing, granulate, dry, granulate, the operations such as subpackage make granule.
Wherein, the ratio of described volatile oil to be lactiflorenol and spathulenol with mass ratio be 1.5:2 mixes, the extracting method of described purple taro extract is: the tuber getting new light violet taro, the soak by water 4h of 11 times amount is added after smashing to pieces, filter decoction liquor, then the water adding 5 times amount in filtering residue continues to decoct 1.5h, filters decoction liquor, merge twice decoction liquor and be condensed into clear paste, carry out spraying dry again, cross 100 mesh sieves, be purple taro extract, purple taro has mass dissipating and swelling eliminating, the effect of removing toxic substances of dispeling the wind, and its water boiling and extraction thing treatment to urticaria has good effect, the extracting method of described Ye Ning nettle extract is the dry herbs of: Qu Ye Ning fiber crops, 5min is dried at being placed in dehydrator 55 DEG C, pulverize with pulverizer after taking-up, cross 40 mesh sieves, the mass concentration adding 7 times amount is the alcoholic solution of 76%, supersonic extracting method is used to carry out supersound extraction, arranging ultrasonic power is 380W, Extracting temperature is 39 DEG C, extraction time is 1.9h, gained extracting solution is added flocculating agent flocculate with chitosan to filter, vacuum drying is carried out after gained filtrate is concentrated, spraying dry obtains fine powder again, cross 120 mesh sieves, obtain Ye Ning nettle extract, Ye Ning fiber crops have heat-clearing and toxic substances removing, effect that calmness is dispeled the wind, contained by its ethanol ultrasonic extraction thing, effective ingredient is more, effect is better, the extracting method of described thin fringe Lycopodium clavatum extract is: get the thin fringe Lycopodium clavatum herb dried, be placed in dehydrator to dry, arranging bake out temperature is 60 DEG C, drying time is 7min, coarse powder is ground into disintegrating machine, cross 30 mesh sieves, coarse powder is added in Chinese medicine flash extracter, adding 12 times amount mass concentrations is the alcoholic solution of 81%, extract four times, each 90 seconds, merge extractive liquid, with the ultrafiltration through membranes that aperture is 0.018 μm, gained filtrate is concentrated until crystal is separated out, the drying of gained crystal is pulverized with crystal pulverizer afterwards, cross 150 mesh sieves, obtain thin fringe Lycopodium clavatum extract, thin fringe Lycopodium clavatum extract has dispelling wind and relieving, the effect of removing toxic substances and promoting subsidence of swelling, Drug therapy for urticaria has good curative effect, described microcrystalline Cellulose is filler, has stronger adhesion, is convenient to granulate, described pregelatinized Starch is binding agent, is modified starch, can increase mobility and the compressibility of medicine, described carboxymethyl starch sodium is disintegrating agent, very easily expands after water suction, thus accelerates the dissolving of medicine, is convenient to absorption of human body, described micropowder silica gel is lubricant, has good mobility and tack, is convenient to grain forming.
Embodiment 3:
Treating an oral preparations for urticaria, is be grouped into by the one-tenth of following weight portion: paeonol 30 parts, lentinan 26 parts, betulic acid 25 parts, tannin 20 parts, volatile oil 18.5 parts, cupreol 16 parts, camellianin 15 parts, Cyproheptadine 14 parts, flavonoid glycoside 10 parts, purple taro extract 5.3 parts, wild Ning nettle extract 4.2 parts, thin fringe Lycopodium clavatum extract 3.6 parts, vitamin C 0.16 part, Citrin 0.11 part.
The preparation method for the treatment of the oral preparations of this urticaria is: by the paeonol of described composition by weight, lentinan, betulic acid, tannin, cupreol, camellianin, Cyproheptadine, flavonoid glycoside, purple taro extract, Ye Ning nettle extract, thin fringe Lycopodium clavatum extract, vitamin C and Citrin blender stir 15min with the rotating speed of 300r/min, gained mixture super micron mill is ground into fine powder, cross 200 mesh sieves, again volatile oil is sprayed directly on fine powder, then microcrystalline Cellulose 12 parts is added, pregelatinized Starch 10 parts, carboxymethyl starch sodium 9 parts, micropowder silica gel 9 parts, by mixing, granulate, dry, granulate, the operations such as subpackage make granule.
Wherein, the ratio of described volatile oil to be lactiflorenol and spathulenol with mass ratio be 1.5:2 mixes, the extracting method of described purple taro extract is: the tuber getting new light violet taro, the soak by water 5h of 12 times amount is added after smashing to pieces, filter decoction liquor, then the water adding 6 times amount in filtering residue continues to decoct 2h, filters decoction liquor, merge twice decoction liquor and be condensed into clear paste, carry out spraying dry again, cross 100 mesh sieves, be purple taro extract, purple taro has mass dissipating and swelling eliminating, the effect of removing toxic substances of dispeling the wind, and its water boiling and extraction thing treatment to urticaria has good effect, the extracting method of described Ye Ning nettle extract is the dry herbs of: Qu Ye Ning fiber crops, 5min is dried at being placed in dehydrator 60 DEG C, pulverize with pulverizer after taking-up, cross 50 mesh sieves, the mass concentration adding 7 times amount is the alcoholic solution of 82%, supersonic extracting method is used to carry out supersound extraction, arranging ultrasonic power is 450W, Extracting temperature is 48 DEG C, extraction time is 2.3h, gained extracting solution is added flocculating agent flocculate with chitosan to filter, vacuum drying is carried out after gained filtrate is concentrated, spraying dry obtains fine powder again, cross 120 mesh sieves, obtain Ye Ning nettle extract, Ye Ning fiber crops have heat-clearing and toxic substances removing, effect that calmness is dispeled the wind, contained by its ethanol ultrasonic extraction thing, effective ingredient is more, effect is better, the extracting method of described thin fringe Lycopodium clavatum extract is: get the thin fringe Lycopodium clavatum herb dried, be placed in dehydrator to dry, arranging bake out temperature is 65 DEG C, drying time is 8min, coarse powder is ground into disintegrating machine, cross 40 mesh sieves, coarse powder is added in Chinese medicine flash extracter, adding 12 times amount mass concentrations is the alcoholic solution of 85%, extract four times, each 90 seconds, merge extractive liquid, with the ultrafiltration through membranes that aperture is 0.021 μm, gained filtrate is concentrated until crystal is separated out, the drying of gained crystal is pulverized with crystal pulverizer afterwards, cross 150 mesh sieves, obtain thin fringe Lycopodium clavatum extract, thin fringe Lycopodium clavatum extract has dispelling wind and relieving, the effect of removing toxic substances and promoting subsidence of swelling, Drug therapy for urticaria has good curative effect, described microcrystalline Cellulose is filler, has stronger adhesion, is convenient to granulate, described pregelatinized Starch is binding agent, is modified starch, can increase mobility and the compressibility of medicine, described carboxymethyl starch sodium is disintegrating agent, very easily expands after water suction, thus accelerates the dissolving of medicine, is convenient to absorption of human body, described micropowder silica gel is lubricant, has good mobility and tack, is convenient to grain forming.
The application of oral preparations of the present invention in treatment urticaria:
One, animal toxicity test:
1, animal is selected and administration: choose 150 white mice, body weight is between 30-40 gram, be divided into 1 group, 2 groups, 3 groups, 4 groups, 5 groups at random, often organize 30,1 group is matched group, all the other are experimental group, 1 group of every day gives normal saline, and 2 groups, 3 groups, the 4 groups granules gavaging the embodiment of the present invention 1 to 3 respectively, take the granule of the embodiment 2 of 5 times amount to 5 groups of white mice, observe about 10 days, the reaction of record white mice every day.
2, test data statistics and result: any specific response does not appear in matched group 1 group within the observation period, 2 groups, 3 groups, 4 groups white mice show do not have any symptom jeopardizing vital sign to occur through the relative recording data of body weight, defecation, blood test etc., the internal organs damage that solution plane 5 groups of white mice do not occur over administration and cause, visible oral preparations safety of the present invention, toxic and side effects is little.
Two, clinical data:
1, inventor chooses the clinical patient of 280 routine urticaria, and patient does not have notable difference in state of an illness feature, is convenient to contrast.Its symptom is shown in skin pruritus, has Tuanfeng County's shape to occur, and in the scarlet or pale asphyxia colour of skin, edema, with having a headache in various degree, feel sick, the diseases such as stomachache, it is divided into four groups at random, often organize 70 people, wherein one group is matched group, takes the medicine of current therapies urticaria, take the granule of the embodiment of the present invention 1, embodiment 2 and embodiment 3 preparation to its excess-three group patient respectively, consolidate again after transference cure and take 2 days.
2, criterion of therapeutical effect:
(1) fully recover: clinical symptom disappearance, avoid anaphylactogen as far as possible, recur no longer easily;
(2) effective: symptom takes a turn for the better, and physical function makes moderate progress;
(3) invalid: symptom is without improvement, unchanged before and after treatment.
3, statistical result is treated:
Table 1-tetra-group comparitive study
| Group | Case number | Recovery from illness | Effective | Invalid | Untoward reaction | Total effective rate % |
| Embodiment 1 | 70 | 54 | 14 | 2 | 0 | 97.1 |
| Embodiment 2 | 70 | 56 | 13 | 1 | 0 | 98.6 |
| Embodiment 3 | 70 | 53 | 14 | 3 | 0 | 95.7 |
| Matched group | 70 | 38 | 19 | 13 | 5 | 81.4 |
4, conclusion: as seen from Table 1, the oral preparations for the treatment of urticaria of the present invention has good clinical effectiveness, total effective rate reaches more than 95.7%, have that dispelling wind is antipruritic, heat-clearing and toxic substances removing, spleen invigorating dehumidifying, antibacterial, infection, antianaphylactic effect, scalable human body immunity simultaneously, reduces side effect, can be used for the treatment of the urticaria of recurrent exerbation, side effect is little, evident in efficacy.
Although describe with reference to its specific embodiments and illustrate the present invention, those of skill in the art will recognize that and can make various change, amendment and replacement when not deviating from the spirit and scope of the present invention to it.Such as, owing to being treated the change of the responding ability of the people of particular condition, the effective dose beyond the preferred dose as above set forth may be suitable for.Similarly, the pharmacology observed responds may basis and rely on selected particular active compounds or whether there is pharmaceutical carrier and preparation type and mode of administration used and become, and changes or difference according to this kind of expection that object of the present invention and practice are contemplated in result.Therefore, the invention is intended to only by following patent requirement scope restriction and these claim should explain as broadly as possible in rational degree.
Claims (7)
1. treat the oral preparations of urticaria for one kind, it is characterized in that, be grouped into by the one-tenth of following weight portion: paeonol 10-30 part, lentinan 8-26 part, betulic acid 7.4-25 part, tannin 6-20 part, volatile oil 5.5-18.5 part, cupreol 4-16 part, camellianin 3-15 part, Cyproheptadine 3-14 part, flavonoid glycoside 2-10 part, purple taro extract 0.7-5.3 part, wild Ning nettle extract 0.6-4.2 part, thin fringe Lycopodium clavatum extract 0.4-3.6 part, vitamin C 0.03-0.16 part, Citrin 0.01-0.11 part.
2. a kind of oral preparations for the treatment of urticaria as claimed in claim 1, it is characterized in that, described volatile oil is lactiflorenol and spathulenol.
3. a kind of oral preparations for the treatment of urticaria as claimed in claim 1, it is characterized in that, the extracting method of described purple taro extract is: the tuber getting new light violet taro, adds the soak by water 3-5h of 10-12 times amount after smashing to pieces, filters decoction liquor, the water adding 5-6 times amount again in filtering residue continues to decoct 1-2h, filter decoction liquor, merge twice decoction liquor and be condensed into clear paste, then carrying out spraying dry, cross 100 mesh sieves, be purple taro extract.
4. a kind of oral preparations for the treatment of urticaria as claimed in claim 1, it is characterized in that, the extracting method of described Ye Ning nettle extract is the dry herbs of: Qu Ye Ning fiber crops, 5min is dried at being placed in dehydrator 50-60 DEG C, pulverize with pulverizer after taking-up, cross 30-50 mesh sieve, the mass concentration adding 7 times amount is the alcoholic solution of 70-82%, supersonic extracting method is used to carry out supersound extraction, arranging ultrasonic power is 310-450W, Extracting temperature is 30-48 DEG C, extraction time is 1.5-2.3h, by the remove impurity of gained extracting liquid filtering, vacuum drying is carried out after concentrated, spraying dry obtains fine powder again, cross 120 mesh sieves, obtain Ye Ning nettle extract.
5. a kind of oral preparations for the treatment of urticaria as claimed in claim 1, it is characterized in that, the extracting method of described thin fringe Lycopodium clavatum extract is: get the thin fringe Lycopodium clavatum herb dried, be placed in dehydrator to dry, arranging bake out temperature is 55-65 DEG C, drying time is 6-8min, coarse powder is ground into disintegrating machine, cross 20-40 mesh sieve, coarse powder is added in Chinese medicine flash extracter, adding 12 times amount mass concentrations is the alcoholic solution of 77-85%, extract four times, each 90 seconds, merge extractive liquid, with the ultrafiltration through membranes that aperture is 0.015-0.021 μm, gained filtrate is concentrated until crystal is separated out, the drying of gained crystal is pulverized with crystal pulverizer afterwards, cross 150 mesh sieves, obtain thin fringe Lycopodium clavatum extract.
6. a kind of oral preparations for the treatment of urticaria as described in claim 1 to 5 any one, it is characterized in that, its preparation method is: by the paeonol of described composition by weight, lentinan, betulic acid, tannin, cupreol, camellianin, Cyproheptadine, flavonoid glycoside, purple taro extract, Ye Ning nettle extract, thin fringe Lycopodium clavatum extract, vitamin C and Citrin blender stir 15min with the rotating speed of 300r/min, gained mixture super micron mill is ground into fine powder, cross 200 mesh sieves, again volatile oil is sprayed directly on fine powder, cold preservation is sealed after sterilizing, namely the oral preparations of described treatment urticaria is obtained.
7. a kind of preparation method for the treatment of the oral preparations of urticaria as described in claim 1 to 6 any one, it is characterized in that, in described oral preparations, add microcrystalline Cellulose 6-12 part, pregelatinized Starch 5-10 part, carboxymethyl starch sodium 5-9 part, micropowder silica gel 4-9 part makes granule by operations such as mixing, granulation, drying, granulate, subpackages.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107875331A (en) * | 2017-12-05 | 2018-04-06 | 程庸堂 | A kind of compound medicine for treating nettle rash |
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| CN1033240A (en) * | 1988-11-24 | 1989-06-07 | 张善义 | A kind of urticaria granule compound method |
| CN103446201A (en) * | 2012-05-29 | 2013-12-18 | 江中药业股份有限公司 | Composition for prevention and treatment of allergic diseases and preparation method thereof |
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| CN1033240A (en) * | 1988-11-24 | 1989-06-07 | 张善义 | A kind of urticaria granule compound method |
| CN103446201A (en) * | 2012-05-29 | 2013-12-18 | 江中药业股份有限公司 | Composition for prevention and treatment of allergic diseases and preparation method thereof |
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| CN107875331A (en) * | 2017-12-05 | 2018-04-06 | 程庸堂 | A kind of compound medicine for treating nettle rash |
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Application publication date: 20160511 |