CN105411845A - Preparation packaging method - Google Patents
Preparation packaging method Download PDFInfo
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- CN105411845A CN105411845A CN201511030815.5A CN201511030815A CN105411845A CN 105411845 A CN105411845 A CN 105411845A CN 201511030815 A CN201511030815 A CN 201511030815A CN 105411845 A CN105411845 A CN 105411845A
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- Prior art keywords
- soft film
- cavity
- preparation
- described soft
- layer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses a preparation packaging method. The preparation packaging method comprises steps as follows: two mutually attached soft films are softened; two corresponding sides of each soft film and the bottoms of the two soft films are connected in a sealing manner; mutually opposing acting force is applied to the middles of the two soft films, so that the middles of the two soft films are expanded outwards and deform, and a cavity with an opening in the top is formed; a preparation is filled into the cavity from the opening; the tops of the two soft films are connected in a sealing manner, and the opening is closed to seal the cavity. The soft films are expanded and formed by applying the acting force to the softened soft films, so that the volume, larger than that of a cavity formed in a natural state, of the cavity can be obtained, more medical solutions can be accommodated in the cavity, the volume of a film material in a unit area is increased to a certain extent, the utilization rate of the material is increased, and the production cost is reduced.
Description
Technical field
The present invention relates to preparation packaging field, particularly relate to a kind of preparation packing method.
Background technology
Present liquid drug formulation packaged form is varied, and soft packaging has the soft bag of PVC film and non-PVC film soft-bag etc., and the packaging of hard has plastic bottle, glass bottle, ampoule and plastic ampoule etc.Be not difficult to find out, the softening trend of the infusion solutions packing of product, do not cover low capacity formulation products field, the packaged forms such as existing glass ampule, plastic ampoule have its advantage but its drawback exists equally, frangible, easy pollution, should not the problem such as terminal sterilization can not be ignored, this just needs a kind of packaged form that can solve the problem.And flexible package exactly can solve the problem.In addition, existing packed in flexible pouchy is all thin film molding in its natural state, and in order to ensure that its bag of internal volume is greater than loading amount, need to make sack with more film, cost compare is high.
The molding mode of present liquid preparation packaging, hard packing generally completes under temperature higher material semi-molten state, and then after cooling, material cooled sclerosis is formed and is used for the cavity of receiving medical liquids; Soft package is then adopt high temperature that material local melting is soldered to form closed space together, and the naturalness then by soft package self produces cavity.
In the middle of above-mentioned packaged form, for hard packing, due to the material that needs a person with the qualifications of a general be heated to semi-molten state under just can realize molding, so need temperature higher, this is all a test for aspects such as service life of equipment or safety in utilization, and, if the constituent of material itself is not up to standard, easily separate out noxious substance under high temperature, will significant problem be produced.In addition, because material has been in semi-molten state, material cell is all free state, and when being subject to extraneous factor, have the risk come off, the fine particle split away off will become the impurity in medicinal liquid, has an impact to the safety of medicinal liquid.
For soft package, the film itself used due to soft bag does not have good ductility, so need cavity volume when making molding to be greater than medicinal liquid loading amount, and the normal usage space of guarantee.In addition, due to present main trend, non-PVC film just progressively replaces PVC film, approves widely with its nontoxic winning.And non-PVC film is as a kind of material of Component comparison complexity, and its cost is relatively high, need to make sack with more film, cost is higher.
Therefore, the cost of preparation soft package how is reduced and to improve safety be the current technical issues that need to address of those skilled in the art.
Summary of the invention
The object of this invention is to provide a kind of preparation packing method, can reduce costs and safety is provided.
For solving the problems of the technologies described above, the invention provides a kind of preparation packing method, comprising:
The soft film of softening two-layer mutual laminating;
Be tightly connected the both sides of two-layer described soft film and bottom;
The middle part of two-layer described soft film is applied to the active force mutually deviated from, make the outside dilatancy in middle part of two-layer described soft film, form the cavity that top has opening;
By described opening to fill preparation in described cavity;
Be tightly connected the top of two-layer described soft film, closes described opening and described cavity is sealed.
Preferably, be tightly connected described in the both sides of two-layer described soft film and bottom comprises:
Separation seal connects two-layer described soft film;
The middle part of two-layer described soft film is applied to the active force mutually deviated from, the cavity that formation top has opening comprises:
The middle part of two-layer described soft film is applied to the active force mutually deviated from, two-layer described soft film forms multiple described cavity with opening.
Preferably, split the described soft film between multiple described cavity, form multiple independently described cavity.
Preferably, the described soft film in preset range around the described cavity of excision is also comprised.
Preferably, the described soft film being also included in both sides, described cavity top shears tearing notch.
Preferably, the described soft film being also included in described cavity bottom prints preparation information.
Preferably, the soft film of described softening two-layer laminating is specially the described soft film of the two-layer laminating of thermoplastic.
Preferably, the be tightly connected both sides of two-layer described soft film, bottom and top is specially the both sides of the two-layer described soft film of heat seal welding, bottom and top.
Preferably, the described active force that the middle part of two-layer described soft film is applied mutually to deviate from be specially to top there is described opening described cavity in blow.
Preferably, the active force applying mutually to deviate to the middle part of two-layer described soft film is specially the outside evacuation of two-layer described soft film.
Preparation packing method provided by the invention, can soften the soft film of two-layer mutual laminating; The both sides of the two soft that is tightly connected film and bottom; The middle part of two soft film is applied to the active force mutually deviated from, make the outside dilatancy in the middle part of two soft film, form the cavity that top has opening; To chamber perfusion in vivo preparation; Final closing openings makes cavity seal.
Soft film expansion molding is made by the mode soft film after softening being applied to active force, the die cavity volume larger than naturalness molding can be obtained, hold more medicinal liquid, improve the volume of film material unit are to a certain extent, improve the utilization rate of material, reduce production cost.When film material expands, deformation rate is identical everywhere, and after distortion, thickness is even everywhere, there is not local weak, does not deposit hard crisp situation of easily breaking after shaping.And, be convenient to terminal sterilization, not easily broken, be convenient to store and transport, and easier medicinal liquid is all extruded and the pollution of extraneous air can not be subject to when using.
Accompanying drawing explanation
Fig. 1 is the FB(flow block) of a kind of detailed description of the invention of preparation packing method provided by the present invention;
Fig. 2 is the front elevational schematic of the preparation packaging that a kind of detailed description of the invention of preparation packing method provided by the present invention is produced;
Fig. 3 is the schematic side view of the preparation packaging that a kind of detailed description of the invention of preparation packing method provided by the present invention is produced;
Fig. 4 is the front elevational schematic of multiple preparation packagings that a kind of detailed description of the invention of preparation packing method provided by the present invention is produced.
Detailed description of the invention
Core of the present invention is to provide a kind of preparation packing method, can reduce costs and provide safety.
In order to make those skilled in the art person understand the present invention program better, below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.
Please refer to Fig. 1 to Fig. 4, Fig. 1 is the FB(flow block) of a kind of detailed description of the invention of preparation packing method provided by the present invention; Fig. 2 is the front elevational schematic of the preparation packaging that a kind of detailed description of the invention of preparation packing method provided by the present invention is produced; Fig. 3 is the schematic side view of the preparation packaging that a kind of detailed description of the invention of preparation packing method provided by the present invention is produced; Fig. 4 is the front elevational schematic of multiple preparation packagings that a kind of detailed description of the invention of preparation packing method provided by the present invention is produced.
In the preparation packing method that the specific embodiment of the invention provides, comprise step:
S1: the soft film of softening two-layer mutual laminating.Two soft film is specially the first film 1 and the second film 2, and the common periphery forming cavity 5, wherein softening object is for the ease of making the outside dilatancy of two soft film in follow-up work.Soft film can be non-PVC film, also can adopt the film of other materials, as PVC film, all within protection scope of the present invention.
Particularly, the method for softening soft film is thermoplastic two soft film, controls softening degree be convenient to control by temperature; also other softening modes can be adopted; as used softening agent, as long as hardening again after soft film deliquescing can be made, all within protection scope of the present invention.
S2: the both sides of the two soft that is tightly connected film and bottom.The middle part of two soft film is made to keep released state, even if define between two soft film only by the space that top is in communication with the outside, for follow-up work.Wherein both sides and bottom are relative bearing, are as the criterion with the state of soft film during fill preparation.
Particularly, the both sides of the two soft that is tightly connected film and the method for bottom are heat seal welding, ensureing sealing effectiveness and convenient operation, also can adopting other connected modes, as used bonding mode, all within protection scope of the present invention.
S3: the middle part of two soft film is applied to the active force mutually deviated from, make the outside dilatancy in the middle part of two soft film, forms the cavity 5 that top has opening.Due to be just tightly connected before both sides and bottom, middle part and top are in released state, simultaneously due to through sofening treatment before, after applying the active force mutually deviated from, the middle part of two soft film can be out of shape by outside even inflation, defines the cavity 5 with opening, for holding preparation.
Particularly, the method active force mutually deviated from applying to the middle part of two soft film be there is cavity 5 from opening to top in blow.Being blown to cavity 5 inside by opening, by controlling air-blowing quantity and blowing speeds, the control to cavity 5 state can be realized.
Also can adopt additive method, by the outside evacuation of two soft film, active force can be applied to two soft film equally in this way.Adopt the mode of evacuation foreign gas can be prevented the impact of soft film, all within protection scope of the present invention simultaneously.
S4: by opening to fill preparation in cavity 5.By above-mentioned steps, define the cavity 5 with opening, inside fill preparation, preset liquid level 3 until arrive, control the amount of formulation in each cavity 5.Wherein preparation can be liquid, also can be semifluid or colloid etc., all within protection scope of the present invention.
S5: the top of the two soft that is tightly connected film, closing openings makes cavity 5 seal.After fill completes, needing top seal to form sealing 6, having formed hermetic cavity 5, for preserving preparation.Meanwhile, additional interface can also be set at sealing 6 place, be convenient to fill and the discharge of preparation.
Particularly, the method at the top of the two soft that is tightly connected film is heat seal welding, ensureing sealing effectiveness and convenient operation, also can adopting other connected modes, as used bonding mode, all within protection scope of the present invention.
In the preparation packing method that above-mentioned detailed description of the invention provides, each step can be carried out successively according to order, and wherein softening and expansion molding can carry out, all within protection scope of the present invention simultaneously.
Soft film expansion molding is made by the mode soft film after softening being applied to active force, the die cavity volume larger than naturalness molding can be obtained, hold more medicinal liquid, improve the volume of film material unit are to a certain extent, improve the utilization rate of material, reduce production cost.When film material expands, deformation rate is identical everywhere, and after distortion, thickness is even everywhere, there is not local weak, does not deposit hard crisp situation of easily breaking after shaping.And, be convenient to terminal sterilization, not easily broken, be convenient to store and transport, and easier medicinal liquid is all extruded and the pollution of extraneous air can not be subject to when using.
In the preparation packing method that the specific embodiment of the invention provides, multiple cavity 5 can be produced simultaneously, when both sides and the bottom of the two soft film that is tightly connected, separation seal connects two soft film, can think that multiple soft film connects as one, namely separation seal is equivalent to the both sides sealing soft film.When applying active force, multiple cavity 5 with opening can be formed, when blowing in opening, can blow simultaneously, also can blow successively.The multiple cavitys 5 formed are set up in parallel, and are on same straight line.
When forming multiple cavity 5, needing to split the soft film between multiple cavity 5, forming multiple independently cavity 5, the soft film in cavity 5 surrounding preset range can also be excised simultaneously.Can increase work efficiency and save material, reducing costs further.
Cavity 5 is opened during for the ease of using; tearing notch 4 can be sheared on the soft film of both sides, cavity 5 top; simultaneously in order to provide preparation information 7; soft film bottom cavity 5 can print preparation information 7; the position of above-mentioned measure can be adjusted, all within protection scope of the present invention according to practical situation.
Above preparation packing method provided by the present invention is described in detail.Apply specific case herein to set forth principle of the present invention and embodiment, the explanation of above embodiment just understands method of the present invention and core concept thereof for helping.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improve and modify and also fall in the protection domain of the claims in the present invention.
Claims (10)
1. a preparation packing method, is characterized in that, comprising:
The soft film of softening two-layer mutual laminating;
Be tightly connected the both sides of two-layer described soft film and bottom;
The middle part of two-layer described soft film is applied to the active force mutually deviated from, make the outside dilatancy in middle part of two-layer described soft film, form the cavity that top has opening;
By described opening to fill preparation in described cavity;
Be tightly connected the top of two-layer described soft film, closes described opening and described cavity is sealed.
2. preparation packing method according to claim 1, is characterized in that, described in the be tightly connected both sides of two-layer described soft film and bottom comprise:
Separation seal connects two-layer described soft film;
The middle part of two-layer described soft film is applied to the active force mutually deviated from, the cavity that formation top has opening comprises:
The middle part of two-layer described soft film is applied to the active force mutually deviated from, two-layer described soft film forms multiple described cavity with opening.
3. preparation packing method according to claim 2, is characterized in that, splits the described soft film between multiple described cavity, forms multiple independently described cavity.
4. preparation packing method according to claim 3, is characterized in that, also comprises the described soft film in preset range around the described cavity of excision.
5. preparation packing method according to claim 4, is characterized in that, the described soft film being also included in both sides, described cavity top shears tearing notch.
6. preparation packing method according to claim 5, is characterized in that, the described soft film being also included in described cavity bottom prints preparation information.
7. preparation packing method according to claim 1, is characterized in that, the soft film of described softening two-layer laminating is specially the described soft film of the two-layer laminating of thermoplastic.
8. preparation packing method according to claim 1, is characterized in that, the both sides of the two-layer described soft film that is tightly connected, bottom and top are specially the both sides of the two-layer described soft film of heat seal welding, bottom and top.
9. the preparation packing method according to claim 1 to 8 any one, is characterized in that, the described active force that the middle part of two-layer described soft film is applied mutually to deviate from be specially to top there is described opening described cavity in blow.
10. the preparation packing method according to claim 1 to 8 any one, is characterized in that, is specially the outside evacuation of two-layer described soft film the active force that the middle part of two-layer described soft film applies mutually to deviate from.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511030815.5A CN105411845A (en) | 2015-12-31 | 2015-12-31 | Preparation packaging method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511030815.5A CN105411845A (en) | 2015-12-31 | 2015-12-31 | Preparation packaging method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105411845A true CN105411845A (en) | 2016-03-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201511030815.5A Pending CN105411845A (en) | 2015-12-31 | 2015-12-31 | Preparation packaging method |
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| CN (1) | CN105411845A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2267818Y (en) * | 1996-07-29 | 1997-11-19 | 谭允熙 | Disposable transfusion bag |
| CN1283089A (en) * | 1997-11-12 | 2001-02-07 | B.布朗医学公司 | Flexible medical container with selectively enlargeable compartments and method for making same |
| US20080033390A1 (en) * | 2004-07-09 | 2008-02-07 | Ajinomoto Co., Inc. | Sealed medical storage |
| CN201085784Y (en) * | 2007-10-18 | 2008-07-16 | 山东新华医疗器械股份有限公司 | Single-group oral siphon liquid double-cavity transfusion soft bag |
| CN101411672A (en) * | 2007-10-19 | 2009-04-22 | 安徽双鹤药用包装有限公司 | Medical infusion soft bag and method for producing the same, and shaping method |
-
2015
- 2015-12-31 CN CN201511030815.5A patent/CN105411845A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2267818Y (en) * | 1996-07-29 | 1997-11-19 | 谭允熙 | Disposable transfusion bag |
| CN1283089A (en) * | 1997-11-12 | 2001-02-07 | B.布朗医学公司 | Flexible medical container with selectively enlargeable compartments and method for making same |
| US20080033390A1 (en) * | 2004-07-09 | 2008-02-07 | Ajinomoto Co., Inc. | Sealed medical storage |
| CN201085784Y (en) * | 2007-10-18 | 2008-07-16 | 山东新华医疗器械股份有限公司 | Single-group oral siphon liquid double-cavity transfusion soft bag |
| CN101411672A (en) * | 2007-10-19 | 2009-04-22 | 安徽双鹤药用包装有限公司 | Medical infusion soft bag and method for producing the same, and shaping method |
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Application publication date: 20160323 |