CN105380608A - Apparatus and method for measuring biologic parameters - Google Patents

Abstract

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.

Description

Measure the instruments and methods of biological parameter

No. 201310097177.3 denomination of invention in the application to be the applying date be on February 26th, 2004 is the divisional application of the Chinese patent application of " instruments and methods measuring biological parameter ".

Invention field

The present invention includes and be placed in support in physiology passage and sensing arrangement, for measuring human body function, and the abnormality indicated by control survey value.

Background of invention

Interference factor and variable can introduce important source of error, and this source of error makes measured biological parameter not have clinical value.In order to avoid described interference factor and obtain undisturbed signal, invasive and half invasive method is used.There is many shortcomings in a little kinds of methods, comprises and be difficult to carry out long-term continuous monitoring.The method of Noninvasive can not bring required clinical usefulness.Be placed on by sensor and there is interference factor with on the skin of the background signal considerably beyond the signal relevant to measured physiological parameter, this interference factor makes to obtain useful with accurate signal clinically.

The most accurate, the accurate and useful clinically approach of the Quantity of heat in appraiser and animal body measures brain temperature.Brain temperature measured value is the key of disease and health status and general indicant, be unique can not by emotional state people vital sign for a change.Other vital sign (heart rate, blood pressure and breathing rate) all can be subject to the impact of emotional state or arbitrarily effect and change artificially.

Body temperature is determined by blood heat, and blood is with far-infrared radiation release heat.Fatty tissue absorbs far infrared, and in fact, the fatty tissue that human body is attached on skin by one deck is completely protected.So, be placed on because previous technology uses the sensor existed on the skin of fatty tissue, utilize the measured temperature of skin not have accuracy and correctness.

Due to by prior art seemingly impossible non-invasively measuring brain temperature, attempt determining temperature in human body, be also called core temperature (coretemperature).At present, a kind of invasive, artificial, method that is troublesome and high cost is used to measure inner (core) temperature, and the method comprises and being inserted in urinary catheter, rectum or esophagus by the conduit with temperature sensor.But this method is not suitable for general measure, and the method is painful, there is potential, fatal complication.

The method of half intrusive mood was also attempted.Abreu is at United States Patent (USP) 6,120, the instruments and methods of measurement core temperature is continuously disclosed in 460, contact lens is used in eye pouch (eyelidpocket), but this contact lens is a kind of device of half intrusive mood, this device should be specified by doctor, and is sometimes not easy this contact lens to be placed in the eye of baby and even adult, and many people fear the eyes touching them.

In the prior art, for carrying out continuous temperature and/or core temperature measurement exists multiple shortcomings and limitations.

Nowadays, be discrete, non-core to the measurement of temperature, and depend on nursing staff.Clinical thermometer must be inserted in the oral cavity of patient, rectum or ear by nursing staff.In order to obtain core temperature, be inserted in human body by pipe, this can cause infecting and serious complication nursing staff's invasive.

Use conventional method measurement core temperature within the hospital and/or continuously, need a kind of invasive operation, being inserted into by pipe in body or by a kind of thermometer pill of picked-up, is very difficult and dangerous.Thermometer pill can cause diarrhoea, measurement be temperature instead of the body temperature of absorbed fluid/food, and if pill blocks the conduit of pancreas or liver, then can cause fatal complication.Owing to there is many interference factors, comprise fatty tissue, sensor is placed on skin and can not produces measured value useful clinically.

Can not obtain accurately and measured value useful clinically by simply sensor being placed on skin, being not only the measured value of brain temperature, and also having the measured value of metabolizing parameters, physical parameter, chemical parameters etc.A key factor there is fatty tissue.Everyone fat is different, along with aging, fat changes, in same person, fat content changed along with the time, and fat slackens the signal from blood vessel, fat absorption heat, fat stops the transmission of undisturbed far-infrared radiation, and fat increases the distance of crossing between measured element and the external sensor being placed on skin surface in human body.

Be necessary to determine a kind of method and instrument, with the sensor be placed on skin, in painless, simple, external and safe mode, Noninvasive, convenient and monitor brain temperature continuously.

Also need to determine a kind of method and instrument, can convenient, Noninvasive, safety and accurately monitor biological parameter, comprise metabolizing parameters, physical parameter, chemical parameters etc.

Need to determine a kind of instruments and methods can measuring biological parameter, by by sensor placement on physiology passage, obtain undisturbed and continuous print biological signals.

Summary of the invention

The invention provides the method for the demand effectively meeting prior art, instrument and system.

In general, the invention provides a set of can separately or the sensor-based system of conbined usage and annunciator, they are designed to close to physiology passage, with measure biological, physics with the parameter of chemistry.From anatomy and physiology, the passage that the present invention finds is a kind of path anatomically, and undisturbed physiological is sent to external by this path.This passage is by direct between function (signal) source in human body and the outside site on the channel end of skin and undisturbedly connect to form.Continuous and the complete data that physiology's channel transfer is relevant with human body physiology.Be presented to from the undisturbed signal in human body on the outside site on channel end.The sensor be placed on the skin of channel end can obtain optimum signal, there is not interference factor and source of error.

Included by the present invention is for by the supporting construction of sensor placement on the skin of channel end.Disclosed device of the present invention, this device is oriented to measures brain temperature, brain function, metabolic function, hydrodynamic function, hydration status, hematodinamics function, human body chemical functional etc.The present invention includes the apparatus and method for evaluating biological parameter, use and there are the paster of the sensor-based system be changed close to physiology's passage, clip, glasses (eyeglasses), the ornaments (gear) etc. worn, to produce the accurate and clinically useful information relevant with the physiological status of wearer, with the safety for improving described wearer and performance, and by providing enough annunciators and the alarm device relevant to monitored biological parameter, to help the life strengthening and preserve described wearer.Other compositions produce and directly or indirectly act on, and act on other devices, or regulate another device or product according to measured biological parameter.

Measuring biological parameter better for exploring, having carried out long-term and careful research, having comprised the discovery to the brain temperature passage (BrainTemperatureTunnel, BTT) in humans and animals body and other biological passage.The present invention identifies the physiology's passage in human body first.The present invention also identifies the channel end being positioned at skin surface first, can obtain optimum signal wherein, and can not exist interference factor and exceed measured signal background noise under measure.The present invention also identifies first and accurately draws the particular geometric and the position that comprise the passage of main entry site.The present invention also identifies the accurate location of sensor-based system on main entry site first, to obtain signal best.Carry out careful research, comprised and develop software to characterize infrared radiation, accurately to determine the different aspect of passage.This research is determined, be placed in physiology channel end skin localized area on sensor, can Noninvasive with continuous print mode, in humans and animals, realize the measurement to brain (core) temperature and other human body parameters.

Important function and the key factor of the function of life preservation and people are brain temperature.Cerebral tissue is the tissue of the heat injury being the most easily subject in human body being caused by high temperature and low temperature.Brain temperature determines the maximally related clinically parameter of human body Quantity of heat, and brain is responsible for the 18-20% producing human body heat, in view of brain only percentage of liveweight 2%, this is very special true.The a large amount of heat energy generated in brain are maintained in the space of restriction, and scalp, skull and CSF (cerebrospinal fluid) form a heat insulation layer.By identification BTT of the present invention, overcome adiabatic obstacle, and provide with the physiology of brain of inside and to be physically directly connected.

From anatomy and physiology, brain temperature passage is by the continuous print between the calorie source in brain and the external point of channel end, direct and undisturbedly to connect to form.Physics and the physiological event of the passage end in brain are reproduced the other end on skin.BTT makes it possible to and directly heat transfer complete by passage, and the interference of not received heat absorber element, absorber element can be absorbed in brain as the far-infrared radiation of heat by blood-transmitted.There are needs six features to define BTT.These are characterized as:

1) region of empty calory absorber element, namely fatty tissue must not be contained in this region.This defines the key of temperature channel and required feature,

2) this region must have the end branch of blood vessel, to transmit the heat of complete amount,

3) end branch must be the direct descendant of the blood vessel from brain,

4) end branch must locate on shallow table ground, to avoid heat by deep structure as muscle absorbs,

5) this region must have between sensor and heat energy source one thin with insignificant interface, to produce high heat stream, and

6) this region must not have the arteriovenous circuit of regulate body temperature.

All six features are all present on the skin in the endocanthion district (medialcanthalarea) being positioned at adjacent medial side canthus (medialcornerofeye), and endocanthion district is positioned at inner canthal ligament (medialcanthaltendon) top and is positioned at the inner side 1/3 in upper eyelid.In detail, from the skin that the canthus, inner side of inner canthal ligament is measured, the end diameter in BTT region is about 11mm, and upwards extends about 6mm, then gives prominence to angle sample and extend 22mm again on upper eyelid.

BTT region is fat-free region unique in human body, and it additionally supplies nutrition by end branch, has the shallow blood vessel from cerebrovascular system, and has thin interface and without the loop of regulate body temperature.Nutrition is supplied by the end branch of shallow superior ophthalmic vein in BTT region, superior ophthalmic vein is connected with the direct of cavernous sinus, described cavernous sinus is the endothelium liner system (endothelium-linedsystem) of the venous access in brain, and it is collected and heat energy storage.There is no the arteriovenous circuit of regulate body temperature to the blood vessel of BTT region supply nutrition, and terminate on the skin at adjacent medial side canthus, above endocanthion region, just in time in the beginning in upper eyelid.Undisturbed heat is delivered on the skin in endocanthion region and upper eyelid by this blood vessel, and this can see on the colour of the infrared view shown in Fig. 1 and 2 and black-and-white photograph.Undisturbed heat radiation from brain is passed on the skin surface of channel end.This heat is passed to and is positioned on the fat free skin area of channel end.The blood vessel of transferring heat is just in time positioned at the below of this skin, and therefore infrared radiation is not absorbed by deep structure.

If blood vessel location is very dark, its hetero-organization and chemical substance can absorb heat, and this can make measured value lose Clinical efficacy.Direct transfer of heat occurs, and in human body, the skin in BTT region is the thinnest, and does not have the arteriovenous circuit of regulate body temperature.One is not by the interference of fatty tissue and direct heat transfer concerning very important aspect the temperature survey of the best.

In human body, on this specific and unique region of end of passage, there is not fatty tissue, signal can be obtained uninterruptedly.The combination of those six factors makes it possible on BTT regional location, and launch infrared radiation in the mode of direct heat transfer without interruption and intactly from brain, this can see (Fig. 1-8) in infrared view photo.In this manual, BTT and physiology passage are also called " target area " (TargetArea).

From physical angle, BTT is the equivalent of the brain fever energy passage with high integrated radiant emittance and high heat stream.The temperature of brain is that the heat energy by producing due to metabolic rate adds that the balance deducting the heat taken away by cerebral blood flow in the heat energy passing brain by artery supply is determined.The heat transmitted between tissue and blood capillary is very high, and the temperature of cerebral veins, venae cerebri blood and cerebral tissue keep balancing.Therefore, true temperature and the heat energy of brain can be estimated by the temperature and heat energy measuring cerebral veins, venae cerebri blood.Superior ophthalmic vein and cavernous sinus have one direct and to be interference-freely connected, with 3.6J.ml ^-1. (DEG C) ^-1heat energy capacity, 45% hematocrit delivery cerebral veins, venae cerebri blood.By placing sensor, catching the heat energy transported by cerebral veins, venae cerebri blood at BTT end, evaluating brain thermodynamical reaction, heat energy and brain temperature.

The research relating to BTT and physiology passage comprises various activity and research, comprising: 1) the vitro tissue analysis in mucosa and shallow-layer human body region; 2) perimeter of humans and animals is carried out to the in vivo test of temperature evaluation; 3) functional Angiography Evaluation in the body of calorie source; 4) Senile Mouse of the tectology feature in BTT region; 5) adopt: thermocouple, critesistor and far infrared, the temperature in interior evaluating BTT region; 6) by BTT measured value and ophthalmic anatomical structure be most commonly used to thermometric Current standards (oral cavity) and compare; 7) temperature stability of BTT is determined in cold and hot attack; With 8) infrared imaging and determine isothermal line.Also be developed for evaluating the geometric software of passage and use.With the critesistor similarly calibrated in advance, the temperature in witness mark temperature and BTT region simultaneously.The particular electrical circuit that design has multiple path is tested, and collects data.

Have almost identical temperature signal between the inside conjunctiva anatomical structure that the temperature survey in BTT region is presented at BTT region and eyes, ophthalmic conjunctiva anatomical structure is the extension of central nervous system.Adopt in test the measured temperature of ophthalmic conjunctiva anatomical structure, this by Abreu at United States Patent (USP) 6,120,460 and 6,312, describe in 393.The MTD of BTT and ophthalmic is within 0.1 DEG C (0.18 ℉), and the average regular temperature value of BTT is 37.1 DEG C (98.8 ℉), and the average regular temperature value of ophthalmic is 37 DEG C (98.6 ℉).Preferably compare with the most frequently used standard oral cavity temperature.The temperature voltage signal display in BTT region, when comparing with oral temperature, the horizontal mean height of BTT regional temperature 0.3 DEG C (0.5 ℉).

By motion and greenhouse, cold and hot attack is carried out to experimenter.In BTT region, the reduction of temperature reduces with rising proportional with rising and the temperature in oral cavity.But the rate temperature change in BTT region was than in oral cavity fast about 1.2 minutes, and in some cases, the temperature at BTT position is high 0.5 DEG C (0.9 ℉).Different race, sex and the experimenter at age are evaluated, in different groups, determines the accurate location of BTT, and determine any change anatomically.In all experimenters, BTT is present on identical position, and without significant change anatomically, this can find out from the infrared imaging sample of different experimenter.

This passage is arranged in a crowded anatomical area, and therefore, placement sensor needs specific geometry, to aim at channel end best.Only relative to anatomic marker and supporting construction specifically placement sensor, the clinical usefulness of passage could be realized.This passage be positioned at have unique anatomical mark ad-hoc location on, this mark contributes to defining outside geometry and placed channel end.The Primary Entry Point of passage is the optimum position of placement sensor, requires sensor to be preferably placed on the outward flange of supporting construction.Comprised by the preferred embodiment measuring biological parameter close to physiology passage and the particular geometric degree of sensor placement in supporting construction is set up.

Supporting construction comprises the paster containing sensor.For the object described, any structure containing the means that described structure is fixed on the skin of channel end by a kind of binding agent is called paster, comprises the band with tacky surfaces, such as " BAND-AID " adhesive bandage.Should be appreciated that and can use multiple attachment means, comprise binding agent, in conjunction with the design of spring pressure attachment, based on the design of other adherence methods, the rubber cushion etc. of such as elastic, rubber.

The transformation of the way paster with by sensor placement at channel end, to obtain signal best.Although binding agent can be adopted to be combined with other means, such as, tighten or pressurize, with stably by sensor placement on passage, preferred paster has a viscosity backing and contact skin, is fixed to by paster on this region.

Supporting construction also comprises clip or is placed in having or the structure of adhesive-free of channel end, is fixed on this region by pressure means.The structure that described structure is fixed on the skin of channel end is called clip by any employing pressure means.

The structure worn is worn on head or cervical region by the structure of sensor placement at channel end, comprises the headband with adnexa close to passage, face helmet, the helmet, earphone, around the structure etc. of ear.For describing object, TempAlert, referred to herein as the system of temperature for measuring BTT region, has the device of reporting measurements, and can group alarm device, and when temperature reaches certain level, this alarm device is activated.Supporting construction also comprises any article with sensing device, and wherein said sensing device is positioned in the end of passage.

Supporting construction also comprises the endocanthion sheet of glasses.Herein, endocanthion sheet is also called endocanthion pad, comprises the pad on skin sensing device being placed in the endocanthion district above passage or sheet, described endocanthion sheet is for good and all adhered to or is assembled in glasses.Herein, to be anyly incorporated in glasses (fixing or moveable) and to be called EyEXT, for feeling the parameter of physics and chemistry close to the sensing device of passage.Any have visual performance, eye protection or face guard, and there is the product with the part of channel contact, referred to herein as being glasses, comprise the protective eye lens, mask (comprising the eyeshield etc. of canister respirator, outer branch mask, cloth mask, diving mask, sleep) safety glasses etc. of traditional eyewear, optometry mirror (prescriptioneyeglasses), reading spectacles (readingglasses), sunglasses, any type.

For brain temperature evaluation, passage area is made up of the top at endocanthion district and canthus, inner side.For brain function evaluation, passage area forms primarily of upper eyelid district.For metabolic function evaluation, passage area is made up of the region at adjacent medial side canthus and upper palpebra inferior.

Comprise various supporting construction to the measurement of metabolic function, brain function, immunologic function, physical parameter, physical and chemical parameter etc., this supporting construction has the sensor close to physiology passage.Place sensor, with the skin juxtaposition very close to canthus, inner side, preferably above endocanthion district.This sensor is also positioned in interior 1/3 of upper eyelid.Most preferably, sensor is positioned on the Primary Entry Point of passage, and this inlet point is positioned on the skin of 3mm above 2.5mm and canthus, inner side inside canthus.The diameter of Primary Entry Point is about 6-7mm.By the Primary Entry Point of sensor placement at passage, provide the best site of the physics and chemistry parameter measuring human body.

Except except the sensor of target area and contact skin, should be appreciated that can adopt equally not with the sensor of contact skin.Such as, infrared temperature measuring system can be used.This measurement is according to physical Stefan-Boltzman rule, and wherein 1/4 of global radiation and absolute temperature is proportional, and in WienDisplacement rule, the generation of peak wavelength and temperature are constant.The visual field of non-contacting infrared gear of the present invention is changed, to mate with the size and geometry in skin Shang BTT district.

The visual field needed for application is obtained with various lens known in the art.Such as, but whether limit, thermoelectric pile is changed a social system, and is positioned on skin in the mode in the visual field with the main entry site aiming at BTT region.Then, signal is exaggerated and converts voltage output value to, carries out digitized processing by MCU (microprocessor).

This infrared system is integrated in the supporting construction contacted with human body, such as any one of supporting construction of the present invention.In addition, should be appreciated that infrared system of the present invention can be integrated into the portable or hand-held unit be separated with human body completely.Instrument of the present invention can also be held by operator, this instrument is aimed at BTT region and measures.This instrument also comprises an extension, and it is processed to cosily be placed in BTT position to measure the shape of biological parameter, and does not make experimenter uncomfortable.Be shaped according to the geometry at anatomic marker and BTT position and size in the extension of BTT place and contact skin.Infrared radiation sensor is positioned in extension, with contact skin, to accept the radiation emitted from BTT position.

The invention provides the method for measuring biological parameter, comprising and sensing device is placed on the skin of channel end, produce the numerical value of signal and the measured parameter of report corresponding to measured biological parameter.

The present invention also comprises the method being measured biological parameter by non-contacting infrared temperature algoscopy, comprises and being placed on BTT position by Infrared Detectors, have the visual field comprising BTT position, produces the signal corresponding to measured infra-red radiation.Biological parameter comprises temperature, hematochemistry, metabolic function etc.

Temperature and chemico-analytic ability is carried out to blood constituent and hemoperfusion proportional.Present invention illustrates, be also called the passage area of target area herein, there is the most shallow hemoperfusion of head, directly exchange with brain, and this blood vessel is the direct descendant of cerebrovascular system, and does not regulate the arteriovenous circuit of temperature.It is generally acknowledged, target area has the highest temperature of body surface, and this can find out from the photo of the test of the infrared emission measured from human body and eyes.

The target area found not only has the thinnest and the most uniform skin in whole human body, and is the skin area of unique fat-free layer.Due to the radiation that fat absorption is a large amount of, signal significantly declines.And because the great variety of interpersonal fatty tissue and fatty tissue are due to aging and huge change occurs, other skin areas can only provide inaccuracy and inaccurate signal.In target area, this interference produced by fat deposit can not be there is.In addition, contrary with the skin of other parts of human body, the assemblage characteristic of target area makes it possible to obtain signal and the high signal noise ratio considerably beyond background signal accurately.In addition, the temperature that body temperature such as exists at the skin surface of other parts of human body changes along with environment.

Of the present invention other mainly find, demonstrate target area not by the impact (comprising the test of cold and hot attack) of environmental change.Target area is provided for thermometric optimum position, and it has stable temperature and is not subject to the impact of surrounding.The target area found directly contacts with brain, not by the impact of environment, and provides a kind of natural, that complete heat is closed and stable core temperature.Temperature sensor is non-invasively placed on skin by instruments and methods of the present invention, directly contacts with the thermal source from brain, and not by the interference of heat absorbing element, the accuracy needed for acquisition and clinical usefulness.

This target area very vascular, and be unique cuticle region, wherein the shallow table ground of the direct descendant of cerebrovascular system is located and is covered by the thin skin of the fat-free layer of one deck.End branch's trunk (maintrunk) of vena ophthalmica is just in time positioned at BTT district, and just above inner canthal ligament, this inner canthal ligament supplies nutrition by tremulous pulse in eyelid and socket of the eye angular vein.BTT region on skin is by end and shallow vascularity nutrition, this end and shallow blood vessel terminate in specific fat-free region, without the arteriovenous shunt of regulate body temperature, provide the shallow-layer source of a undisturbed biological signals, these biological signals comprise brain temperature, metabolic function, physical signalling and human body chemistry as glucose content etc.

Infrared spectroscopy is a kind of method based on material absorbing infra-red radiation, identifies described material according to the molecular vibrational mode of its uniqueness, and this vibration mode is depicted as the specific resonance absorbing peak in the infra-red range of electromagnetic spectrum.Various chemical substance absorbs infra-red radiation in the mode of its uniqueness, has the absorption spectrum of itself uniqueness, this depend on its atom with the arrangement of molecule and the pattern of vibration and whirling vibration.The absorption spectrum of this uniqueness makes various chemical substance can have the infrared spectrum of himself fundamentally, is also called fingerprint or feature, can be used to identify each in these materials.Towards the radiation of being launched by measured material containing various Infrared wavelength, according to Beer-Lambert rule, the absorbtivity of radiation depends on the concentration of described measured chemical substance.

Interference factor and variable such as fat, skeleton, muscle, ligament and cartilage introduce important source of error, and because background noise greatly exceeds the signal of interested material, these errors are crucial especially.Because the skin in BTT region does not exist these interference factors, sensor-based system is placed in described BTT region, the optimum signal that noise is minimum can be obtained, comprise spectra measurement.

Because target area does not exist main variation and source of error, such as fatty tissue, disclosed in the present invention be incorporated into spectral device in supporting construction can accurately, non-invasively measuring blood constituent.In addition, there are not other key factors that interference electromagnetic energy is launched in target area, such as muscle, soft bone and bones yet.The blood vessel location of transmitting infra-red radiation is very shallow, and infra-red radiation is passed to the end of passage, does not interact with other structures.The exclusive architecture that infra-red radiation will be crossed over is very thin skin, and this skin does not absorb Infrared wavelength.The present invention includes infrared ray spectral apparatus, obtain measured value useful clinically, accurately and exactly determine the concentration of blood constituent at channel end.

Except electromagnetic energy is delivered to except the spectroscopy of target area, invention further discloses and launch by far infrared heat the instruments and methods measuring interested material from target area.But, except near infrared light spectroscopy and heat are launched, further disclose other devices measuring interested material in target area, comprise electro-osmosis, as carried out melting reinforcement by ionotherapy, or the electric power increases the percutaneous Reverse iontophoresis therapy of liquid.Further, the Optical devices of percutaneous are also integrated in supporting construction, comprise endocanthion sheet (medialcanthalpieces), the nose pad (nosepad) of improvement, and the framework of glasses, settle described device to come close to passage.

Should be appreciated that electric current, the chemical intensifier of hyperacoustic application and flowing, electroporation and other devices, can be used to improve permeability in access sites, such as, improve the flowing of glucose with basic salt.In addition, produce micropore in the target area with other devices of laser or transdermal, be then placed in by sensing device on BTT position, described sensing device can measure chemical substance.

In addition, be assemblied in or be arranged in the pond (reservoir) in the framework of supporting construction such as glasses and pad, can pass through various tactful transdermal delivery substance on BTT position, these strategies comprise iontophoresis, sonar electric osmose, voltage contracting, electroporation, chemistry or physical penetration reinforcing agent, hydrostatic pressure etc.

Except measuring the actual oxygen content in blood, invention further discloses measure oxygen degree of satisfying and the device of oxyhaemoglobin content.In this embodiment, the nose pad of the endocanthion sheet of supporting construction or the glasses of improvement contains LED, and LED launches two kinds of wavelength of about 940nm and 660nm.When blood oxygen changes, the ratio between the light launched with two kinds of frequencies changes, and represents oxygen saturation.Because the end at physiological brain tunnel place measures blood content, measure the content of the oxyhaemoglobin in cerebral arteries blood, this measured value is the most worthy of movement effects (athleticpurposes) and health status monitoring and the parameter of most critical.

The present invention is also provided for measuring the method for biological parameter, and described method comprises BTT region electromagnetic radiation aimed on skin, produces the step of the signal corresponding to the radiation generated and the numerical value converting the signal into measured biological parameter.

Except using by except the passive and wireless electric transmission of cable and communication; The active transmitter containing the minicell be arranged in supporting construction can also be used to carry out active radio propagation.Passive transmitter is supplied to its energy to work by external source.Sensor adopts the different frequency of eucoen mathematic(al) parameter level to transfer signals at a distance.Also ultrasound wave microcircuit can be assemblied in supporting construction, and be modulated by sensor, this sensor can detect the chemistry of target area and the change of physics.Can with the transmission of sound signals signal modulated, particularly under water, because compared with radio wave, the decay of water to sound is less.

A preferred embodiment comprises a kind of supporting construction, this supporting construction comprise be changed to be applicable to wear or by adhesive attachment to the paster on passage, comprise structural supports, for measuring the sensor of biological parameter, power supply, microcontroller and emitter.These parts can be integrated in a system or conduct independently cell operation.Sensor is preferably positioned in the 7mm of genesis outside paster.Instrument of the present invention comprises the temperature sensor be positioned in the outward flange of paster, for sensing temperature.As long as transducing part principle according to the present invention is positioned in the edge of paster, emitter, power supply and other compositions can have any size, can be placed in any part of paster, or be connected on paster.Sensor in paster is positioned on the skin at contiguous endocanthion region (canthus, inner side), is positioned at and is about 2mm place from inner canthal ligament.This sensor preferably includes electric transducer, but also can use the sensor of non-electrical, such as, to the chemical drugs of temperature change response, comprises mylar.

Except paster, another comprises endocanthion pad for the preferred embodiment measuring biological parameter on physiology passage.Endocanthion sheet is a kind of specialised structure, contain for the sensor close to passage, be changed to be applicable to wearing or being attached to passage on juxtaposed glasses, comprise structural supports, for measuring the sensor of biological parameter, power supply, microprocessor and emitter.These parts can be integrated in a system or conduct independently cell operation.By sensor placement in BTT region.Emitter, power supply and other compositions can be placed in other parts of endocanthion pad or glasses.The extension of the nose pad of endocanthion sheet or glasses can to make with BTT juxtaposed sensing device close to physiology passage.

Instrument of the present invention comprises the temperature sensor be positioned in endocanthion pad.Carry out temperature survey, this sensor-based system is positioned at and comprises on the endocanthion angle of eyes and the skin area in upper eyelid.Sensor in endocanthion pad is preferably placed on the skin at contiguous endocanthion region (canthus, inner side).Although; measure one of preferred embodiment of brain temperature to be made up of endocanthion pad; be to be understood that; in protection scope of the present invention; also comprise the nose pad with certain geometry and size; can passage be arrived, preferably be assembled with temperature sensor at the outward flange of described nose pad, for measuring brain temperature and other functions.The present invention also comprises the nose pad containing sensor strengthening and improve, and it adopts specific geometry to be placed in sufficiently on BTT region.

According to of the present invention open, and by utilizing according to anatomic marker of the present invention, sensor accurately can be placed on the skin of channel end.But, owing to there is not the visible instruction in the outside relevant to channel sized and geometry on skin, can attachment device be adopted, visual on skin, draw or Measurement channel end.These attachment devices are useful especially for the nose pad of the glasses assembling endocanthion pad or improvement.

Therefore, adopt the Infrared Detectors of thermocouple or thermoelectric pile can be used as the attachment device determining maximum heat launch point, and draw this region.In this case, the optics shop of selling glasses has thermal imaging system.Optician, technical staff etc. take infrared image or record this region, and the passage of the specific user of real-time positioning.Then, according to thermal infrared images, the nose pad of adjustment endocanthion pad or improvement is to be applicable to specific user.Heat picture according to generating prepares glasses.This can carry out customization preparation according to the individual need of user.The system of any record temperature can be used to three-dimensional colour thermal wave imaging, comprises those systems with maximum visual effect and resolution.

Of the present invention also have a feature to be provided for the method such as carrying out placed channel at spectacles shop, comprises measuring thermal infrared and launching, and according to this infrared emission synthetic image, and detects the step in the region with most high IR emission measure.Another step also comprised is the sensor in adjustment supporting construction, with the Region Matching with maximum infrared emission.

One of described supporting construction comprises the nose pad of endocanthion sheet or glasses.Paster can be prepared with thermal imaging method, but, by paster contains outer indicant, described paster can be placed on passage, this indicant be arranged in permanent anatomic marker as on canthus, inner side.Although the endocanthion sheet of glasses has the outer indicant for accurate placement, because optician is according to the anatomy of user to prepare glasses, thermal imaging method is more suitable for glasses than the outer indicant on the nose pad of the glasses of endocanthion sheet or improvement.

Signal source is crucial for the clinical usefulness of measured value.Brain is the key of human body health status and general indicant.Signal from brain or brain region provides data the most useful clinically.According to another embodiment, will the measurement of descriptive biology parameter.For safety and the function of athlete and soldier, and health status monitoring, in perspiration, the content of sodium and other elements is key factors.

Such as, hyponatremia (sodium content reduction) can cause function to decline, even dead.Due to excessive water intake, can hyponatremia be there is, usually occur in violent sports and military training.Perspiration can be regarded as the ultrafiltrate of blood.The blood vessel of supply skin of head is the branch of central nervous system's vascular system.Content instruction from the chemical substance existed in the perspiration of these blood vessels is present in the content of the chemical substance in cerebrovascular system.Such as, change relative to the speed of sweating from the sodium content in the perspiration of the blood vessel of head.When the sodium level in perspiration reaches specific threshold, instruments and methods of the present invention provides alerting signal can to this specific wearer, thus prevents the death because water intoxication causes or injury.Can determine the existence of various chemical element, gas, electrolyte and the pH of perspiration and skin surface with suitable electrode and sensor, these electrodes and sensor are integrated in glasses and other are worn on head or are fixed in the supporting construction in head or face.These electrodes are preferably microelectrode, and the multiple reactant chemicals that can be present in perspiration or skin surface activates, and different chemical substances and material can diffuse through suitable penetrating film, the sensor that sensitization is suitable.

Such as, but be not limited to, electrochemically sensor is for measuring various analysis things such as glucose, uses glucose oxidase sensor, separately or in conjunction with micro-fluidic system, measures the electrolyte in perspiration with pilocarpine iontophoresis methods.Be to be understood that, except supporting construction of the present invention, other article also can be modified to the concentration of applicable measurement of species as wrist-watch, clothes, footwear etc., such as, be present in the electrolyte in perspiration, but, reduce for the clinical degree of association evaluating the metabolism state of the individuality outside central nervous system.

Human body can cause the change of the pH of the perspiration from brain and Cervical Vessels, permeability and temperature extremely, and the change of material concentration, as lactic acid, and glucose, lipid; hormone, gas, label, infectious agent, antigen; antibody, enzyme, electrolyte as sodium, potassium and chloride, etc.Glasses and any head ornaments can be changed with the material concentration in applicable measurement perspiration.Leg of spectacles end after micro-type glass electrode is assemblied in and is arranged in ear, or be alternately assemblied on the lens edge of forehead, for detecting bivalent cation, as calcium ion, and sodium ion and potassium ion and pH.Chloride-ion detector is for detecting the salinity with skin surface in perspiration.

Much reagent comprises biological warfare agents and HIV virus is present in perspiration, can detect by head and glasses on the face or supporting construction, adopt the sensor of the antibody covering this reagent of opposing, produce photochemical reaction, show as chrominance response and/or gesture skew, then change on voltage or temperature, be detected and be transferred to monitoring station, or reported in this locality by audio or video device.When there is antigen-antibody reaction, electrocatalytic reaction antibody also can produce the signal of telecommunication.It should also be understood that, according to the present invention, the article of other article such as wrist-watch, clothes, footwear etc. or any absorbing sweat can be changed with applicable qualification antigen, antibody, infectious agent, label (cancer, heart, heredity, metabolic, medicine etc.).But to the qualification that these elements away from central nervous system carry out, its clinical degree of association reduces.

Be easy to the fluid of the different content quantized in perspiration, and the concentration of material according to the fluid content calibration in perspiration.In blood chemical substance described in the concentration of chemical substance and molecule and perspiration concentration between relation can be described with mathematics in a computer, and to be programmed.

The present invention also comprises glasses and supporting construction, and the radio frequency sensors wherein can measuring the negative resistance (negativeresistance) of nerve fiber is assembled in glasses or supporting construction.By measuring resistance, the effect of microorganism, medicine and poison can be detected.This system also comprises glasses, and wherein miniature radiosensitive sensor is assembled in described glasses or supporting construction.

Brain has abundant vascular system, and accepts the resting cardiac output of about 15%, and owing to not having fat, this passage provides a best signal that obtains with the dynamic (dynamical) region of evaluating blood.Therefore, the change of blood viscosity can be evaluated from the change of the damping of the vibration microcrystalline quartz be assemblied in glasses or supporting construction, the present invention can be changed with applicable Measure blood pressure, by the intact vascular wall from brain, instantaneous and continuous print monitoring is carried out, with evaluating blood kinetics and hydrodynamics to blood pressure.In addition, provide one to contact microphone, measure arterial pressure with acoustic wave device.

By being assemblied in the micro-hoop (microcuff) in endocanthion pad, or alternately using leg of spectacles, applying pressure to blood vessel.Pressure can also being applied by rigid structure, when producing the sound relevant to haematological disorders, reaching preferred terminal.The characteristic sound of heart contraction (contraction of heart) and diastole (diastole of heart) is caught with microphone.The microphone be integrated in endocanthion pad is modified to be applicable to qualification heart sounds.Pressure converter can be combined in same silicon chip structure for the integrated electronics of signal processing and micropkonic capacitive pressure converter bank as having, and be assembled in endocanthion pad.Motion sensor and/or pressure transducer are assemblied in endocanthion pad and measure pulse.

Reversible mechanical expansion method, photometering or electrochemical method and electrode are arranged in glasses of the present invention or supporting construction, for detecting the concentration etc. of acidity, gas, analysis thing.Oxygen can also be evaluated according to its magnetic properties, or is analyzed by the miniature Polarographic sensor be arranged in glasses or other supporting constructions.The mini-loud hailer be arranged in glasses or other supporting constructions is changed, with the sound of applicable detection from heart, breathing, fluid, voice (vocal) and environment, this sound is by sensing and be transferred to long-range receptor, or reports with local audio and video-unit.Repacking is sensor installation also, at channel end monitoring biological parameter.

Glasses or other supporting constructions also have the element producing and launch discernible signal, and this process is used for location and follows the tracks of individual, especially in military operation.Can also permanent magnetic bead be assemblied in glasses, for above-mentioned tracking.Be assemblied in glasses by the emitter of fixed frequency, as tracking means, this tracking means utilizes minitrack, the frequency accepted from fixed frequency emitter is sent to through satellite, or by global positioning system.Will speed up device be assemblied in glasses detect motion and slow down.Due to the article that glasses are normally not under a cloud, be useful as tracking means for the rescue attempt of locating in the individuality that is kidnaped or military affairs with glasses.

In the use of integrated circuit and transducer, power supply and signal processing technology, development makes various element extremely miniaturization, can be implemented in like this in a unit and assembles several sensor.

The invention provides continuous print automatic monitoring brain temperature, and do not need nursing staff.The present invention can identify a peak value in temperature.Thus carry out correct diagnosis and start treatment in time.Time is for qualification temperature peak and to cause the organism of infection be important.Postpone to identify that peak value and the initial treatment to infecting can cause death.The present invention identifies temperature peak in time and automatically, prevents the generation of complication.

The present invention also reminds user to note hyperpyrexia or hypothermia, makes:

1. suitably hydration;

2. improve performance;

3. improve safety; With

4. in treadmill and other motions, carry out feedback control, to keep suitable hydration and performance.

Every year, many athletes, builder, university students and the general public die from heatstroke without rhyme or reason.Reach certain temperature levels as 40 DEG C once brain, almost irreversible process then occurs.Owing to not having special symptom, after sometime, brain temperature raises rapidly, and heatstroke has one of most high mortality.If this situation is more serious and by the delay longer time, expected result by worse, particularly when carrying out cooling by delay.When ambient temperature is reduced to below level of security, and unmeasured core temperature and when lacking early warning system, hyperthermia and heatstroke can not be prevented.The invention provides a kind of device for continuous monitoring temperature, there is the early warning system and operable cooling provision when needing that prevent from reaching danger level.Instrument is changed a social system, in an unobtrusive manner for athlete, soldier, workman and the general public.

In human body, all chemical reactions depend on temperature.High temperature can cause enzymatic to change and protein denaturation, and low temperature can slow down important chemical reaction.Hydration depends on brain temperature, and body fluid loss can cause brain temperature to raise.The minimal ripple of human body temperature can react on human body performance, increases ill and danger that is threat to life event.Therefore, athlete, motion participant, soldier, police, fireman, forest ranger, millworker, peasant, builder and other professionals have the accurate device of its brain temperature of exact knowledge is important.

When core temperature raises, other are lowered the temperature by breathing and perspire by the blood that muscle utilizes.When temperature is beyond preferred close limit, human body automatically will carry out these activities.Just this blood change finally slackened physical function, and heat induction normal cognitive function is disturbed to the infringement of cerebral tissue.Strenuous exercise can make the heat in muscle produce increase by 20 times.In order to the death preventing hyperpyrexia and caused by heatstroke, athlete will drink water.Owing to being optionally absorb water, generation can cause dead water intoxication in many cases, and this occurs in many healthy personnel, comprises marathon runner and soldier.Except reducing function, water excessive (excessive hydration) or olighydria (dehydration) also can cause death incident.Therefore, individuality has exact knowledge and when to drink water and the accurate device of drinking how much water is important.Monitor brain temperature with the present invention, can realize suitably hydration, athlete and soldier accurately will know when drinking water and drink how much water.

Absorb liquid in time according to core temperature, make it possible to optimize cardiovascular function, avoid hot injury.Owing to having delays from picked-up liquid to this liquid is absorbed by human body, method of the present invention be included in lower core temperature such as 38.5 DEG C time send the signal needing picked-up liquid, to make up this delay, thus avoid exhaustion to show effect.Temperature threshold can be regulated according to each individuality, sports and environment temperature.

In addition, Software for producing can be carried out according to the data obtained from BTT position, make body building (fitness), motion function and safety optimization.Can determine that special exercise person keeps the temperature upper limit of best function, these data are used to Software for producing in contest, instruct this athlete.Such as, athlete is prompted to need to drink cold liquid to prevent from reaching the particular temperature levels by determining to reduce this athletic function.The brain temperature level of determined best function is used to instruct athletic effort (effort) in contest and training.Hyperpyrexia also affects intelligence performance, makes the software based on the data from BTT, with the intelligence of individual method optimizing fireman and physique function.People have different threshold values to Hyperthermic damaging effect, therefore, arrange to all user the ability that a kind of level can cause underusing a people, and in make other people be in danger that function reduces.Equally, temperature decline also can significantly reduce exercise tolerance and mental capabilities, and identical setting is applied to low temperature situation.Determine brain temperature, oxygen and lactic acid content, for athletic endurance training, fitness training, with for monitoring the effect of training.System of the present invention, method and instrument are provided for providing the mechanism improving safety and optimize body building to athlete and entertaining motion participant.

A feature of the present invention is to provide the method for accurately and in time absorbing liquid, comprises measurement brain temperature, reports the signal measured and the step absorbing certain quantity of fluid according to measured signal.Other steps can be comprised, such as, use the annunciator of audio reproduction or visual device to indicate to drink which kind of beverage, and should drink how much reduce core temperature.Should be appreciated that method of the present invention is according to principle of the present invention, temperature survey is combined with the sodium ion measurement in perspiration or blood.

The temperature capability of child is different from adult, and compared with adult, child's human body produces the heat higher relative to its Individual Size.Child regulates with the speed changing body temperature not as adult.In addition, child has the larger skin surface relative to its Individual Size to amass, and this means that they pass through, from skin evaporation, to lose more juicy.Should be appreciated that different size, the endocanthion pad of shape and design can be used for the present invention, comprise child-sized.The Kids eyeglasses being equipped with sensor has the transmitting set of a strengthening, makes it possible to transfer signals to receptor at a distance, reminds father and mother when the temperature levels of danger.Glasses are combined with a kind of detection system, when glasses be removed or when temperature sensor not in the correct way lock-on signal time, this system can send a kind of signal.As explanation, instead of restriction, whether pressure sensor device is combined to the end of leg of spectacles, detect sunglasses and worn, the unexpected decline of pressure signal shows that these glasses are removed, or mistake placement sensor also can produce certifiable signal.Binding agent, double faced adhesive tape or other be used in endocanthion pad for strengthening stationary device, to guarantee more stably to settle.Should be appreciated that glasses can be equipped sensor and carry out testing environment temperature and humidity, make it possible to accurately remind wearer to note affecting heat-regulatory any aspect.

Current industry, nuclear industry and military affairs environment in, individuality is required to wear protective garment.Although protective garment prevents the infringement caused by danger, these clothing improve heat filling rate.Should be appreciated that the present invention can be combined with the clothing with scalable permeability, automatically core temperature is remained in safety margins.

In addition, in by the sea or out of doors movable process, the present invention reminds the danger of the individual hot injury of attention (producing the danger of wrinkle and cancer).When by the sea, when come to matches in stadium in the open, under camping or being exposed to the sun, the emittance of the sun is absorbed and is converted into heat energy.Transfer of heat can cause body temperature to raise to the combination of the different modes of human body, is reflected in brain temperature.When not having sunlight, by transfer of heat, convection current and conduction also can cause body temperature to raise.From environment, absorb heat causes the mean kinetic energy of molecule to increase, and core temperature raises subsequently.

Core temperature level is relevant to the hot injury of skin.After reaching the heat of certain level, the danger that in skin, protein denaturation and collagen are destroyed increases.This can compared with the change occurred in fried egg.After a certain amount of heat radiation of transmission, albumen becomes hard and white structure by liquid and transparent.When albumen reaches uniform temperature level, the change of this structure becomes permanent.Be exposed in the process under the sun, being elevated to a certain degree at core temperature, there is hot injury in such as, the time static level of 37.7-37.9 DEG C of (such as sun tan) immediately, and because protein and collagen are destroyed, increase the danger that wrinkle is formed.Brain temperature raises relevant to the heat radiation amount that human body absorbs, and exposure persistent period of uniform temperature level is multiplied by the indicant that temperature levels is hot injury, wrinkle formation and skin carcinoma.

The invention provides a kind of early warning system, can be established and carry out real-time reminding with the danger preventing further absorptive thermal radiation and reduce skin change should avoid being exposed under sunlight, these dangerous can out of doors active procedure or by the sea time occur.In addition, stop skin to cool fully to the hot injury of skin, the danger increasing dehydration can be caused, thus temperature is raised further.The present invention contributes to being exposed to people under sunlight and keeps beautiful and healthy in motor process out of doors, and enjoys the benefit of the sun and sunlight fully.

By the present invention, for comprising take temperature to exposing the method for carrying out timing in sunlight, reporting measurements and the level according to measurement are avoided under the sun, expose the step exceeding the regular period.

At US and European, hypothermia is the number one killer of outdoor activities.Hypothermia also can reduce athletic function, and can cause injured.Detect hypothermia very difficult, because its complication is very unclear, such as disorientation and trick are clumsy, and they are difficult to make a distinction with common behavior.Unmeasured core temperature and when not having early warning system, when body temperature is reduced to below level of security, because symptom is unclear, can not prevent hypothermia.When skating, diving, climb the mountain and going on a hike, the present invention can remind individuality to note hypothermia.The invention provides for when reaching uniform temperature threshold value, temperature is too high or too low, the device of accurately informing.

The present invention monitors brain temperature continuously, once there is temperature peak or adstante febre, can activate diagnostic system to detect whether there is infectious agent, this can be confined to BTT position is carried out, or infectious agent can be identified in other parts of human body, such as, in blood flow or eye pouch.The present invention can be incorporated in medicine dispensing device, and the signal produced according to BTT position, automatically in drug delivery, comprises transcutaneous device, ionotherapy or by penetrating by infusion.

The present invention also comprises the instrument for family planning.Peak value in this systems axiol-ogy datum temperature and change, determine the stage of ovulation period and menstrual cycle.Women is enable to plan pregnancy or avoid pregnancy.This makes the intrusion apparatus of the time of the monitoring artificial fertilization no longer needed for humans and animals.The present invention can also detect the initial of uterine contraction (childbirth), and animal can be produced safely, and equally, supporting construction also can use on the BTT of animal.

The automatic climate that the present invention also comprises the numerical value measured according to BTT place controls.The temperature of user controls the temperature in car.When human body starts to warm up, the signal from instrument of the present invention automatically opens air-conditioning, alternately, when human body cold then starts heating according to the setting of user.This automatic operation makes human pilot be primarily focused on road, thus reduces the danger of colliding.Be appreciated that other article that can affect body temperature can be controlled by the present invention, comprise the seat of the vehicles.

The atmosphere control system of the current vehicles excessively strong (overpower), because they are designed to the air mass in the cabin of the warm up/down vehicles over a period to come, from an extreme initial temperature to standard temperature.Because people have different heat demand to reach comfort level, always the manual temperature that changes sets, and described manual operations increases energy expenditure further.Such as, the temperature in the vehicles is set and remains on 73 ℉.And after 15 minutes, some feel too cold, and some feel too hot.Then, setting changing is 77 ℉ by passenger, then, after 10 minutes, feels again too hot, needs again to change set point by hand, and this process lasts occurs.Except the Man's Demands of all ages and classes is different, suffer from the people of diabetes and other diseases, and the demand of men and women is also different.

The manual climate controlling regulated continually in compartment, can increase by the fuel consumption of 20%, increase the discharge of pollutant, such as carbon monoxide and nitrogen oxide.

The invention provides a kind of automatic climate to control, wherein brain temperature controls the seat of air-conditioning and the vehicles, makes degree of comfort maximization and fuel consumption is minimized.Invention increases saving of fuel, give off the less pollutant affecting ozone layer, protect environment; By reducing the discharge of toxic fumes, improving public health, reducing the regulation and control diverting one's attention to come weather in hand control car, improve comfort level and the safety of human pilot.

The thermal environment in transport vehicle cabin can be regulated according to the temperature at BTT position, comprise and being measured and non-contact sensor measurement by touch sensor, such as infrared sensor or heat imaging.Any article in the temperature adjustment car of BTT or device, change the temperature in compartment, comprises the carpet etc. on air-conditioning and heater, the seat of the vehicles, door, window, steering wheel, floor.Exemplarily, the temperature of BTT adjusts the thermal exposure through the window of the vehicles, if BTT sends signal, show to feel heat, then the vehicles window can dimmed immediately to prevent more heat into the car, vice versa, if feel cold, the window of the vehicles can change its light penetrability, and more frequent fever ripple is penetrated in car.Any contact human body or the article near human body are conditioned and change its temperature, make vehicle ownership obtain warm comfort level.

Except being described supporting construction for monitoring and adjust the temperature in transport vehicle cabin and thermal imaging system in the present invention, should be appreciated that the contact lens had in the loading eye pouch of temperature sensor also can be modified the temperature regulated in compartment.Exemplary transport vehicle comprises car, truck, train, aircraft, steamer, motorboat etc.

It is also understood that sensor-based system can be included in the sensor at other positions of human body, with temperature and/or the thermal-radiating temperature sensor associated working at measurement BTT position.Heat energy, can be occurred by any one of radiation, convection current etc. to vehicle ownership by item transfer, according to the temperature signal measured at BTT, can adjust the mechanism that heat energy was presented or removed in any transfer.

With the sensor of the sensor of independent any type at BTT position or other parts of associating human body, the invention provides more effective energy system, in the existing of any type or the transport vehicle that is just being developed, make passenger obtain warm comfort level.

Equally, according to according to the temperature of the present invention measured by BTT, by directly or by bluetooth (BlueTooth) technology activating self-operated thermostatic controller, can be implemented in family, office or any localized area and carrying out automatic climate regulation and control.Except convenient and comfortable, this automatization can save energy, because the rough craft change carried out in self-operated thermostatic controller can cause great energy expenditure.

Should be appreciated that any measurement of bldy temperature system can provide automatic climate to control or regulate the temperature of article according to principle of the present invention.

The present invention also comprises for slimming method.The method is included in and reduces monitoring temperature in the process that loses weight of described body weight based on increase human body heat.This system alert athlete notes the program of losing weight, and prevents by the overheated damage that causes or death.This system can monitor body temperature in sauna bath, vaporium and hot spring etc., as a part for the program of losing weight, in case stop loss wound, and improves effect.

Further, the method, except keeping fit, also based on the brain temperature that the present invention measures, by the temperature providing auto-mechanism to control environment around temperature and human body, realizes memory reinforcing and improves function.The mankind spend 1/3 time of its life nearly for sleep.Many body temperature changes occur in sleeping process.Metabolism all in human body and enzymatic reaction all depend on sufficiently high temperature levels.The temperature that suitably controls environment, to meet the demand of the human body temperature such as in sleeping process, has important function to metabolism.Suitable ambient temperature and environment temperature and human body temperature match, not only make people sleep better, and the efficiency improving enzymatic reaction can be reached, mental capacity and immunoreation ability are improved.Various device, the article of such as blanket, clothes, medicated cap, mattress, medicated pillow or any contact human body or contiguous human body are changed, according to automatically raising from temperature signal of the present invention or reducing the temperature of described article.

Human body becomes colder naturally at night, and due to temperature impact, many people have a rest insufficient and constantly toss about in bed.Because this occurs with unconscious motion again and again, and people does not wake up, and can not change the temperature that stimulation such as raises indoor temperature or raising electric blanket.The present invention automatically changes the temperature of environment temperature or article, to meet the temperature requirements of people.This is useful especially for baby, old man, diabetics, neurological disorders, heart disease and other patient with sympotoms various, because the nerve reagency of this colony to the change of human body temperature is low, this colony can be subject to more infringement at night, except causing production capacity due to forfeiture sleep and reducing, also add the danger suffering from complication.Therefore, the temperature of electrical blanket or environment temperature are automatically regulated according to BTT temperature.When the low temperature of BTT being detected by instrument of the present invention, wireless or wired signal is transferred to article to raise its temperature, when for electrical blanket or heating system, automatically regulates self-operated thermostatic controller to present more frequent fever amount.

The present invention also provides the apparatus and method used together with biofeedback activity.Brain temperature signal from the sensor at BTT position produces a feedback signal, as shown tone or the visual display of temperature, if brain temperature raise (frequency is higher and red) or reduce (frequency is lower and blue), a series of tone or color identified.This display device can be wired in the supporting construction that BTT position keeps sensor.

Cooling head can not change brain temperature.Although athlete, soldier, fireman, builder etc. throw cold water on toward head or use fan, be still in the danger of heatstroke.From medically, this is a kind of situation of danger, because feel that cooling is considered to internal cooling at head, and when brain is in fact still in infringement that heat causes and heatstroke dangerous, is still carrying out sports.Other medical science relevant to thermal perturbation is attacked and is related to the response time.The recovery reaction of brain to temperature change is slower than core temperature (temperature measured in rectum, bladder, esophagus and other Ti Nei mechanisms).Therefore, the measured value in body may show stable temperature, and brain temperature is still beyond level of security, there is the danger of the damage to cerebral tissue caused due to temperature decline or body temperature rising.The uniquely medically acceptable approach of the damage to cerebral tissue preventing temperature from causing is by the continuous monitoring to brain temperature provided by the invention.

The present invention utilizes the active or passive sensor be combined in a large number in supporting construction to come close to physiology passage, to measure biological parameter.The present invention preferably includes as all functions part (functions) in the micro semiconductor chip of an integrated circuit, is combined with sensor, process and transmission unit and control circuit.

Other embodiment comprises carries out temperature survey to heating and body temperature disturbance (hyperpyrexia and hypothermia) and scans screening (massscreening) in a large number, comprise human body radiation detector, referred to herein as being BTTThermoScan, comprise the thermal imaging system of the heat picture obtaining BTT end.BTTThermoScan of the present invention has sufficiently high temperature and the isothermal line discriminative power of at any time monitoring temperature, and measurement can not be made to handle by man's activity.

BTTThermoScan detects brain temperature, and provide corresponding to BTT region image or comprise the image in BTT region.

BTTThermoScan comprises that converted to by heat radiation can the photographing unit of video image on a display screen, such as at the image that figure lA, 1B, 3A, 4A, 5A, 5C, 7A, 7B, 8A, 8B, 9A and 9B (for animal) sees, the image most preferably seen in fig. ib.In visible scope, can detect and photograph from human body and BTT field emission radiant energy out.

In infra-red range, the skin at people BTT position has very high emissivity (e in Stefan-Boltzman formula), no better than black matrix.Capture through with the video image seen to BTTThermoScan camera lens, customized software is changed the isothermal line figure of display color, and software is used to obtain the image of Figure 1B, and wherein the point of any 99 ℉ be yellow.For detecting SARS, this software is changed and is presented at any point more than 100 ℉ in BTT region with yellow.When yellow occurs on a display screen, this software is changed to provide a kind of automatic early-warning system.Therefore, when brain temperature passage area occurs on a display screen with yellow, this precaution device is activated.Should be appreciated that and can adopt any Color scheme.Such as, threshold temperature is with red display.

As shown in Figure 7A and 7B, carry out cold challenge trial, and demonstrate the heat emission stability in BTT region.Cold attack, by when experimenter is exposed to cold, comprises in the face of cold air generator (such as air-conditioning and fan), drinks ice-cold beverage, health is immersed in cold water, and is injected on skin by ethanol, catches thermal infrared imagery composition continuously.Although change human body temperature artificially by artificial method, the radiation from BTT region remains complete, and occurs with bright white point on BTT region.In contrast, be exposed in cold process, face is dimmed gradually, represents that facial temperature reduces.Fig. 7 B shows the face darker than Fig. 7 A, and from the heat radiation in BTT region without any change.

Except cold attack, carry out heat attack improve body temperature artificially, comprise sports, get sun, in the face of heater, drink, smoke and health soak in the hot water.In all these tests, BTT region keeps stable, and the temperature of other parts of face changes, its reflection temperature of skin instead of brain temperature of inside.As illustrated in FIGURES 2 A-2 C, except BTT end, brain completely and environment.Prior art can produce too many false positive, and in airport and customs, some, owing to having drunk some wine or having smoked one not by checking, make device of the prior art become invalid.Therefore, the invention provides a kind of system and method, when using thermal imaging detection system, can eliminate and reduce false negative and false positive.

Many useful application can be realized, comprise and in a large number screening is scanned to heating, the person that screens hyperpyrexia after sport events (such as marathon) in athlete, the person that screens hypothermia in soldier and hyperpyrexia person are to select the individuality of the most applicable fight on physiology, and any other the thermal perturbation person under the condition of any installation BTTThermoScan.

A kind of specific application comprises and prevents the attack of terrorism, and terrorist infects certain disease (such as, SARS-SARS (Severe Acute Respiratory Syndrome)), and outsmarts clinical thermometer when entering and carrying out the attack of terrorism national and carry out heating inspection to hide.

SARS, owing to not eliminated, may become the serious threat of terrorism.By natural propagation, SARS becomes mass destruction weapon, no matter make by force all cannot be eliminated with diplomacy.In order to propagate the object of infection in target country, terrorist can accept infection.Adopt prior art, any device all can be outsmarted, and when there is real adstante febre, existing device can be measured as normal temperature.Terrorist adopts simple means, such as, wash one's face with cold water or ice or be immersed in cold water, to deal with any device for measuring heating in prior art, comprises existing infrared imaging system and clinical thermometer.When the thermal physiology of human body is measured by prior art and evaluated, can be managed, the measurement carried out can produce the false negative of heating.

The terrorist suffering from SARS spreads disease easily via any means, comprise and shaking hands with office worker on a large scale, individually every day, time spent in the environment such as cinema, arenas, department store, government building and other places that limit, or contaminant water and drinking water source.The infected people of all that does not also know oneself to catch an illness, and start SARS to propagate to kinsfolk, colleague, friend and other people, these people can infect other people again subsequently, cause disease popularity.

From medically, spreading intentionally SARS has immeasurable destruction.Do not know that the people oneself caught an illness can arrive hospital and carry out routine examination, or the Ren Huiqu hospital done not feel like oneself carries out routine examination.The patient coming hospital can infect this disease with other people.Very weak by the patient made a definite diagnosis, be easy to infect SARS.It is have destructive that SARS propagates within the hospital, needs to close this hospital.Therefore, a people suffering from SARS can cause whole hospital to be closed.In view of the people infecting this disease may go to different hospitals, several hospital may be contaminated, has to partially or fully be closed.This can make regional healthcare system paralyse, and patient must be transferred to other hospitals.These patients may infect SARS, and this propagation circulation can be constant.If by an organized way carrying out this attack of terrorism in multiple area, national multiple healthcare system can be paralysed, and in addition, countless doctor and nurse can infect SARS, and this can slacken healthcare system owing to shortage of staff and further.

The key of the catastrophic effect preventing the attack of terrorism from causing is prevented.Instruments and methods of the present invention can detect SARS, can not be dealt with by artificial means.BTTThermoScan of the present invention is placed in a national border, harbour and airport, can prevents control temperature artificially from measuring and the possible attack of terrorism.System of the present invention can at any time with identify the disease that the existence of SARS is relevant with other and heating in any environment.

In addition, screening can be scanned with the BTTThermoScan be arranged on finishing line in a large number to athlete.For any with the athlete of the high fever of top level through finishing line, siren will be activated.Therefore, because any delay when identifying hyperpyrexia can cause heatstroke, and even dead, can carry out immediately nursing to obtain best clinical effectiveness.BTTThermoScan is modified to check at least part of BTT region.BTTThermoScan detects brain temperature, provides the image corresponding to or comprise BTT region.Although athlete waters on head, BTTThermoScan, by detecting the temperature at BTT place, accurately detects the heat energy situation of human body.

Body temperature disturbance such as hyperpyrexia or hypothermia, can slacken intelligence and the physical function of any workman.When affecting by thermal perturbation, especially easily there is function and decline in driver and pilot, and has the danger had an accident.The baffle plate that BTTThermoScan can be assemblied in the vehicles or aircraft monitors body temperature, catches the heat picture of the BTT of driver or pilot with the photographing unit of BTTThermoScan, once disturbance be detected, just provide a prompting.Should be appreciated that and can any thermal imaging system is assemblied on the vehicles or aircraft, monitoring body temperature, and remind driver and pilot.

BTTThermoScan is also included in Influenza flu season monitoring to the child in danger and the scanning screening carried out of being grown up.Due to the shortage of nursing staff, automatic screening greatly can add the people that good general's health care is supplied to needs.When the student passed by before infrared camera be accredited as there occurs body temperature disturbance (such as generate heat) time, conventional digital camera will be activated, take pictures to this student.This photo sends to the nursing staff of school by Email, and this nursing staff determines that this student needs nursing, also can automatically use the digital photograph stored.

Hospital, factory, family or any meeting, from automatically scanning screening or individually screening the place benefited body temperature disturbance person, can adopt according to thermal imaging instrument of the present invention.

Should be appreciated that to use and be included in the instrument that the radiation source of about 556nm wavelength is launched at BTT position, determine the concentration of hematochrome.The hematochrome be present in the erythrocyte of BTT end absorbs the wavelength of 556nm in a large number, the content being determined hematochrome by the radiation of reflecting received by photodetector.Evaluate blood flow by known thermal-radiating content, according to a kind of mathematical model, higher thermal exposure represents larger blood flow.

Pass through the visible anatomical shape in presented outside, touch sensor, non-contact sensor and Thermal Imaging Camera can be settled easily.Under the skin in the endocanthion district at adjacent medial side canthus, cerebral veins, venae cerebri blood can be seen.Therefore, the method for measuring tempeature comprises and visually detects the blueness in BTT region or bluish skin, and by sensor placement or be adjacent to blue or bluish region.For the experimenter that skin color is darker, be adjacent to the characteristic feature of the different skin structure in the BTT district at canthus, inner side as the benchmark measured.

The present invention includes for collecting thermal-radiating device from BTT position, for settling temperature-sensitive device to accept from the thermal-radiating device at BTT position and the device for described heat radiation being converted to brain temperature.The present invention is also provided for the method determining brain temperature, and described method comprises the heat emission of collecting from BTT position, produces the signal corresponding to collected heat emission, processes this signal and report temperature level.The present invention also comprises the apparatus and method on settling position temperature sensor being correctly placed in BTT position.

Another object of the present invention is, provide be modified by sensor placement on the skin of channel end to measure the supporting construction of biological parameter.

An object of the present invention is, the instruments and methods measuring brain temperature is provided, comprises the paster containing the sensor be placed on physiology passage, adhesive tape, elastic device, clip etc.

An object of the present invention is, the instruments and methods measuring brain temperature is provided, comprises containing the thermal imaging system of sensing from the infrared sensor of the infra-red radiation of BTT.

An object of the present invention is, provide the Multifunctional spectacle being equipped with endocanthion pad, this endocanthion pad contains the sensor being positioned in and physiology passage being measured biological parameter.

Another object of the present invention is, is provided for new method and the instrument of at least one measured in brain temperature, chemical functional and physical function.

Of the present invention also have an object to be provide and be worn on adult and child's instrument with it.

Another object of the present invention is to provide a kind of instrument, its by being wiredly connected to annunciator, be wirelessly transmitted to annunciator and by audio frequency, video or at least one in the mode reported in this locality of the device of sense of touch can be reported in the signal that passage place produces, such as, by being assembled in the vibrator in supporting construction.

Of the present invention also have another object to be provide the instrument making wearer avoid dehydration or excessive hydration's (water intoxication).

Of the present invention also have an object to be, provides and improve athlete and the motion function of participant and the method for safety and instrument.

Of the present invention also have an object to be provide the supporting construction of sensor placement on passage, its can by the athlete in training and contest, training and militant soldier, work in workman and at least one in the public in normal activity wear.

Another object of the present invention is, according to the core temperature of vehicle ownership, carries out weather and automatically controls the control with the seat of the vehicles, improves the safety in the vehicles and comfort level.

An object of the present invention is, provide according to the horizontal force of measured biological parameter in the method for the second device and instrument.

Another object of the present invention is, supplying method and instrument, the sunlight caused by preventing heat radiation damage and the prompting wearer when temperature reaches specific threshold, keeps skin health, reduces the danger of the wrinkling danger of skin and reduction skin carcinoma.

Another object of the present invention is, the method providing the method for losing weight based on heat to realize controlling to lose weight and instrument.

Another object of the present invention is, is provided in based in raising body temperature slimming project, reminds athlete to prevent method due to the overheated damage that causes or death and instrument.

Of the present invention also have an object to be provide the method and instrument that can monitor heating and temperature peak.

Of the present invention also have an object to be provided for the device carrying out family planning by detecting ovulation period.

Another object of the present invention is, the signal being provided for producing according to passage is method and the instrument of drug delivery.

Of the present invention also have an object to be provide the method and the instrument that improve occupational safety by monitoring biological parameter continuously.

Of the present invention also have an object to be provide to have and be positioned in monitor the product of the sensor apparatus of biological parameter on passage, its can be fixed or be assemblied in spectacle frame, glasses nose pad, wear in the structure of ornaments and clothes at least one.

Feature of the present invention is also the signal transmitting self supporting structure, to act at least one in exercise equipment, bicycle, telecontrol equipment, protective garment, footwear and medical treatment device.

Of the present invention also have an object to be provide the Signal transmissions produced by passage to treadmill and other training machinery, to keep suitable hydration, prevent the disturbance of user generation body temperature.

The present invention also has another object to be provide by monitoring the instruments and methods of biological parameter with active or passive device close to physiology passage.

Feature of the present invention is also that the Signal transmissions of self supporting structure is in the future to wrist-watch, pager, mobile phone, computer etc.

When with reference to following description, and by reference to the accompanying drawings, these and other object of the present invention, and many advantages be specified will become more apparent.

Accompanying drawing explanation

Figure 1A is the thermal infrared images of face, display brain temperature passage.

Figure 1B is the thermal infrared coloured image of the face of Practical computer teaching, display brain temperature passage.

Fig. 2 A shows the schematic diagram of physiology passage.

Fig. 2 B is the cross sectional representation of head part, display channel.

Fig. 2 C is coronalplane (coronalsection) schematic diagram of the cavernous sinus of display Fig. 2 B.

The thermal infrared imagery of Fig. 3 A face, display channel.

Fig. 3 B is the geometry of the schematic diagram of the image in Fig. 3 A, display channel end.

Fig. 4 A is the thermal infrared images of face side, the full view of the main entry site of display brain temperature passage.

Fig. 4 B is the schematic diagram of the image in Fig. 4 A.

Fig. 5 A is the thermal infrared images in face front, the main entry site of display brain temperature passage.

Fig. 5 B is the schematic diagram of the image in Fig. 5 A.

Fig. 5 C is the thermal infrared images of the face side in Fig. 5 A, the main entry site of display brain temperature passage.

Fig. 5 D is the schematic diagram of the image in attached view 5C.

Fig. 6 is face schematic diagram, the main entry site of display channel and the gross area of marginal portion.

Fig. 6 A is the schematic diagram of display brain temperature passage and metabolism passage.

Fig. 7 A and 7B is the thermal infrared images of the face before and after cold attack.

Fig. 8 A and 8B is face's thermal infrared images of different subject, display channel.

Fig. 9 A and 9B is the thermal infrared images of animal, display channel.

Figure 10 is the preferred embodiment of supporting construction is worn in display perspective view according to a people of the present invention, and this supporting construction is made up of the paster with the active sensor be positioned on the skin of channel end.

Figure 11 is another preferred embodiment of supporting construction is worn in display perspective view according to people of the present invention, and this supporting construction is made up of the paster with the active sensor be positioned on the skin of channel end.

Figure 12 A is a preferred embodiment of supporting construction is worn in display front view according to people of the present invention, and this supporting construction is made up of the paster with the passive sensor be positioned on the skin of channel end.

Figure 12 B is the flexible side view of supporting construction be shown in Figure 12 A.

Figure 13 is the schematic diagram of a preferred embodiment.

Figure 14 is the schematic diagram of the preferred embodiments of the invention relevant to processing unit (plant) and product.

Figure 15 A-15E is the schematic diagram that display the present invention uses the preferred embodiment of indicant.

Figure 16 A-16C is the perspective view of preferred embodiment, and display people wears the supporting construction assembled as paster.

Figure 17 is the perspective view that display people wears another optimal case of the supporting construction assembled as clip, and a sensor is positioned on the skin according to channel end of the present invention.

Figure 18 is the perspective view of another preferred embodiment, and display people wears supporting construction, and sensor is positioned on the skin of channel end, and is connected by wire.

Figure 19 A1,19A2,19B, 19C and 19D are the preferred geometry of supporting construction and sensing device and the schematic diagram of size.

Figure 20 A-20C is the schematic diagram of preferred supporting construction physical dimension the outer rim relative to sensing device.

Figure 21 A and 21B is the schematic diagram of the optimum position of sensing device.

Figure 22 A-22C is the perspective view of a preferred embodiment, and display people wears supporting construction, and this supporting construction is assembled into endocanthion pad, and sensor is positioned on the skin according to channel end of the present invention.

Figure 23 A and 23B is the perspective view according to alternative embodiment of the present invention, and show the supporting construction be made up of improvement nose pad, sensor is positioned on the skin of channel end.

Figure 24 is the perspective view of another preferred embodiment according to supporting construction of the present invention.

Figure 25 is the perspective view of a preferred embodiment of supporting construction, and display comprises other structures of sensor.

Figure 26 A is the rearview of the preferred embodiment of the supporting construction with display device.

Figure 26 B is the front view of the preferred embodiment of the supporting construction with display device.

Figure 27 is the decomposition view of another preferred embodiment, display three-piece supporting construction.

Figure 28 A is the decomposition view of a kind of preferred embodiment of supporting construction, and display can dismountable endocanthion sheet.

Figure 28 B is the rearview of the detachable endocanthion sheet of Figure 28 A.

Figure 28 C is the front view of the detachable endocanthion sheet of Figure 28 A.

Figure 29 is the rearview of the preferred embodiment of the supporting construction being assembled into clip, and this clip is used on glasses.

Figure 30 is the perspective view of the alternative embodiment of the supporting construction with endocanthion pad, and this endocanthion pad uses viscosity backing to be fixed in another structure.

Figure 31 A is the top view of a kind of alternative embodiment of supporting construction, and this supporting construction has the hole for fixing endocanthion pad.

Figure 31 B is the enlarged perspective of the ingredient of the supporting construction of Figure 31 A.

Figure 31 C is the side view of the ingredient of the supporting construction of Figure 31 B.

Figure 31 D is the side view of fixing endocanthion sheet on the support structure.

Figure 32 A is the perspective view of the people wearing the supporting construction be made up of cap in the corner of the eyes, and in this corner of the eyes, cap is fixed on above the nose pad of the glasses of rule.

Figure 32 B be Figure 32 A the corner of the eyes in the perspective view of cap.

Figure 33 A is the decomposition view being fixed on cap in the corner of the eyes on nose pad.

Figure 33 B is the perspective view that in the corner of the eyes, cap is fixed to the final result on nose pad.

Figure 34 is the perspective view of the rotatable nose pad be modified, by sensor placement on the skin according to channel end of the present invention.

Figure 35 is the schematic diagram of another preferred embodiment of the present invention, adopts spectral reflectance.

Figure 36 is the schematic diagram of display according to the people of another preferred embodiment of the present invention, adopts spectral transmissions.

Figure 37 is the cross-sectional view of another preferred embodiment of the present invention, adopts heat emission.

Figure 38 adopts head-mount ornaments as the side view of the alternative embodiment of supporting construction.

Figure 39 produces thermoelectric power to supply the schematic diagram of the preferred embodiment of sensor-based system.

The perspective view of the preferred embodiment that Figure 40 animal uses.

Figure 41 A and 41B is the perspective view of the alternative embodiment of Portable supporting structure, and sensor is positioned on passage.

Figure 42 A and 42B is the schematic diagram of display according to noncontacting proximity sensor of the present invention.

Figure 43 A-43C is the figure of the preferred embodiment of outstanding (coneextension) diameter of display taper.

Figure 44 A and 44B shows geometry and the shape of alternative epitaxial tip.

Figure 45 A and 45B shows geometry and the profile of exemplary supporting construction, containing touch sensor.

Figure 46 A-46D shows geometry and the shape of the nose pad of exemplary endocanthion pad or improvement.

Figure 47 is exemplary block diagram, shows the preferred embodiment of infrared imaging system of the present invention.

Figure 48-51 be display infrared imaging system of the present invention be assembled in supporting construction diverse location on show the schematic diagram of the Temperature changing of people.

Figure 52 A is the schematic diagram that display infrared imaging system of the present invention is assembled on a vehicle.

Figure 52 B is the representative of the instructional images using the infrared imaging system of Figure 52 A to generate.

Figure 53 shows the flow chart of illustrating for the method in the present invention.

Figure 54 A and 54B is the perspective view of the preferred embodiment be incorporated on head ornaments.

The perspective view of the preferred embodiment that Figure 55 is made up of mask and airbag (airpack).

Figure 56 A and 56B shows the schematic diagram according to BTT inlet point detection system of the present invention.

Figure 57 is the schematic diagram of display BTT inlet point automatic checkout system.

Figure 58 A-58C is the schematic diagram of display according to alternative supporting construction of the present invention.

Figure 59 shows the schematic diagram of the two-way heat energy stream in BTT.

Figure 60 A-60C shows the sketch map of preferred BTT heat bag (thermalpack).

Figure 61 is the schematic elevational view of display according to preferred BTT heat bag of the present invention.

Figure 62 is the schematic cross-sectional view of BTT heat bag.

Figure 63 A is the schematic cross-sectional view of BTT heat bag in a relaxed state.

Figure 63 B is that the BTT heat of Figure 63 A wraps under impaction state with the schematic cross-sectional view consistent with BTT region.

Figure 64 A has the transversal schematic diagram in side of the head of the people of BTT heat bag.

Figure 64 B is the front schematic view of the ocular of the BTT heat bag with Figure 64 A.

The perspective view of the BTT heat bag of Figure 65 display containing rod 866.

Figure 66 shows the schematic diagram of another embodiment of two bag BTT heat bag.

Figure 67 A shows the front schematic view of BTT heat mask.

Figure 67 B shows the side section schematic diagram of the BTT heat mask of Figure 67 A.

Figure 67 C shows the BTT heat mask of Figure 67 A at face and the front view on BTT.

Figure 68 A shows the front view that the supporting construction be made up of eye adornment (eyewear) fixes BTT heat bag.

Figure 68 B shows the front view being fixed BTT heat bag by the molecular supporting construction of folder.

Figure 69 A shows the perspective view of preferred BTT heat bag.

Figure 69 D display is placed in the perspective view of the BTT heat bag of Figure 69 A on BTT.

Figure 70 shows the schematic diagram of hand-held non-contacting BTT measuring device.

Figure 71 A-71C shows the schematic diagram of the sense measuring device of hand-held contact.

Figure 72 is the schematic images showing hand-held touch sensor measuring device.

Figure 73 display is attached to the schematic diagram of the heat quantity transfer device on BTT measuring device.

Figure 74 shows the perspective view of the preferred measuring device of animal.

Figure 75 A-75E shows the figure of heat signal.

Figure 76 A and 76B shows the schematic diagram of antenna alignment.

Figure 77 A-77C shows the schematic diagram of the supporting construction be made up of loop fasteners.

Figure 78 display fills the schematic diagram of the lensed supporting construction be made up of loop fasteners.

Figure 79 A and 79B is the perspective view of alternative supporting construction.

Figure 80 shows the schematic diagram of the supporting construction of Figure 79 A.

Figure 81 A and 81D is the schematic diagram of preferred support structure.

Figure 81 C and 81D shows the perspective view of the supporting construction of Figure 81 A.

Figure 82 shows the electricity distribution of the supporting construction be made up of eye adornment.

Figure 83 shows the perspective view of automatic Climate Control System.

Figure 84 is the front view of display as the nose Airway dilation device of the extension of paster of the present invention.

Figure 85 A-85C is the schematic diagram of display according to test kit of the present invention.

Detailed description of the preferred embodiments

Describe the preferred embodiments of the invention will be considered to for purposes of clarity with accompanying drawing, particular term elaboration.But the present invention is not limited in selected particular term, should be appreciated that each specific term comprises all technically equivalent ones, these equivalents work to reach similar purpose in a similar fashion.

Figure 1A gives the thermal infrared images of the face of display physiology passage.The image shows the image of brain temperature passage (BTT) end, represent with the bright white point in half inside endocanthion district and upper eyelid.BTT end on skin has specific geometry, border and interior zone, and Primary Entry Point is positioned at the upper inboard portion in endocanthion region, is located immediately at the lower part in upper eyelid, and 4mm inside endocanthion angle.In endocanthion district thus along canthus, inner side directly down, the 5mm down from canthus, inner side, then advances to upper eyelid on this border, sideline is from the middle part in upper eyelid, as the region that limits, with fan-shaped horizontal expansion, top edge is from upper eyelid, half portion is divided.

The instruction of this colour code is present in the temperature range of people face.Hottest point bright white point instruction, and the coldest region black indicates.Temperature between the hottest and most cool region is with the different tones displays in grey scale.Because nose forms primarily of soft bone and bones, thus having less blood content, is cold (being shown as black).This is the reason that cold injury is most commonly in nose.

Upper palpebra inferior around region (appearing dimmed) very vascular near the eyes, and fatty tissue content is few, hotter.Skin under eyelid is very thin, and does not have fatty tissue.But, in this region, not there are other conditions needed for definition brain temperature passage.

The requirement of BTT also comprises and there is end branch to present total amount of heat, and end branch is the direct descendant from brain, and location, end branch shallow table ground, avoids far infrared radiation to be absorbed by other structures, and there is not the arteriovenous circuit of regulate body temperature.Therefore, BTT is exactly the skin area in canthus, inner side and upper eyelid, is can close to the unique location of brain temperature passage.The skin of surrounding eyelids presents undisturbed signal, to carry out chemical measurement with spectrum, is considered to metabolic pathway, can obtain the signal of Chemical Evaluation best, and this signal is not used in the integrated radiant emittance evaluating brain.

Figure 1B is the colored schematic images of thermal infrared of the people face of Practical computer teaching, shows geometry and the zones of different of brain temperature passage and peripheral region in detail.Only minority biology such as some beetles and Serpentis can see such radiation, but people cannot see.Infrared image makes sightlessly to become visible.Therefore, geometry and the size of passage can be quantized preferably.The center of the channels peripheral district that isothermal colored schematic diagram display is red and yellow-white, the Primary Entry Point of BTT end is positioned at the upper inboard portion in the endocanthion district above corner of the eyes internal ligament.

Primary Entry Point is the best region obtaining signal.It is uniform that this image also shows heat energy on two BTT positions.Because other regions comprising forehead do not have six features needed for aforesaid definition BTT, described region has lower integrated radiant emittance, is shown as light green color and bottle green.Therefore, forehead is not suitable for measuring integrated radiant emittance.Whole nose has low-down radiant energy, be shown as blueness and violet region, and nose is shown as brown, has the minimum temperature of face.Therefore, nasal area is not suitable for measuring biological parameter.

Fig. 2 A is physiology access diagram, particularly brain temperature passage.From physiology, BTT is brain fever energy passage, and it shows as high integrated radiant emittance and high heat stream, can be characterized as being brain fever energy passage.This passage stores heat energy, provides a kind of interference-free path, heat energy is transported to the other end on skin from the passage end the cavernous sinus of brain inside, transfers heat energy on the skin surface of channel end with the form of far infrared radiation.There is high heat stream at channel end, the feature of channel end is to have a thin interface, and the thickness at heat stream and interface is inversely proportional to.

The integrated radiant emittance (P) of channel end is defined as P=σ * e*A*T ⁴, wherein σ is Stefan-Boltzman constant, σ value=5.67x10 ^-8w.m ^-2.K ^-4, e is the emissivity in this region.Because channel end provides best radiation areas, due to the T in equation ⁴, when brain temperature increases, integrated radiant emittance raises rapidly.As in the test that the present invention mentions prove, the radiant energy of BTT with than the radiant energy in tongue and oral cavity faster speed occur.

BTT position on skin is a very little region, also less than 0.5% of body surface area.But this extremely little region in human body provides the best region obtaining signal, to measure physiology and chemical parameters.

Fig. 2 A display has heat energy 12 brain stored therein 10.BTT20 comprises brain 10, is stored in the heat energy 12 in brain 10, is stored in the heat energy in passage 14 and the heat energy 16 transferring to external channel end.Heat energy 12,14,16 represent by the black arrow of formed objects and shape.Arrow has formed objects, represents the undisturbed heat energy from passage end to the other end, is characterised in that intra passage temperature is identical.

Heat energy from the cavernous sinus of brain 10 is transferred to the end of passage 16, and by uncrossed cerebral veins, venae cerebri bloody path, transfer of heat speed is very fast.Passage also has the wall 18 representing blood vessel wall, and blood vessel stores heat energy with identical temperature, and as leading to the pipeline of outside (skin surface) 19 from human body 10 inside, terminates with tail vein 17, by total amount heat energy transfer on described skin 19.

Skin 19 is very thin, can produce high heat stream.As compared to the skin 39,49 respectively in non-passage area 30 and 40, the thickness of skin 19 can be left in the basket.Due to skin 19, high heat stream can be produced, when on the skin 19 sensor being placed on BTT20 end, heat balance can be reached rapidly.

At other skin areas of face and whole human body, and in the exemplary non-passage area 30 and 40 of Fig. 2, being connected with the direct blood vessel of brain except lacking, several interference phenomenon occurring, comprises self-absorption and heat gradient.1. self-absorption: this is with before being transmitted into body surface, the phenomenon that deep tissues optionally absorbs the wavelength of infrared energy is correlated with.The self-absorption content of infrared energy and type are unknown.At body surface, those are preferably launched is faint, this is because the heat of the self-absorption confusion reigned of other layers is launched and the spectral signature of skimble-skamble analyte, represents illustratively with the various sizes of arrow 34a-36g and 44a-46g of Fig. 2, shape and direction.Therefore, the self-absorption of non-passage area stops the heat transmitting useful to measurement to be presented to body surface naturally.2. heat gradient: there is a heat gradient, higher than the temperature of shallow-layer compared with deep layer, compare with thinner arrow 36e with 46e more shallow with location illustratively, represent compared with thicker arrow 36d and 46d of deep layer.When through various layer such as fat and its hetero-organization Isolated Muscular meat, photon occurs excessively and the variable scattering of height, causes energy loss.

Contrary thus, passage area 20 is consistent with without infrared energy absorption, and blood vessel is positioned at body surface.This makes it possible to uninterruptedly infrared energy is delivered to skin surface 19, and is delivered on hygrosensor, such as, by the Infrared Detectors be placed on side by side on skin 19.Only there is the skin 19 that one deck is very thin in BTT district, and tail vein 17 is just in time in the below of described thin interface skin 19, and BTT district does not exist heat gradient.The heat energy 16 produced by the tail vein 17 stretching to epidermis 19 is corresponding with undisturbed brain (true kernel) temperature of human body.Realizing reaching thermally equilibrated preferred path with brain temperature is by central veins system, and this system is left brain and entered eye socket as superior ophthalmic vein.Compared with central veins blood, the low 0.2-0.3 DEG C of arterial blood, this arterial blood does not reach real balance with brain temperature.Although in some cases, arterial blood is important, Venous system is the preferred heat energy conveyer measuring brain temperature.In some cases, arterial blood temperature is for determining whether can be important to cool brain by arterial blood.

The feature of non-channel region 30 and 40 is to there is heat absorbing element.Non-channel region 30 and 40 dotted line is described, and is characterised in that the defect of the heat transfer interference existed by the disorder in heat absorption composition and described non-channel region 30 and 40.Before the infrared energy launched by darker organized layer arrives skin surface, various organized layer and other compositions of non-channel region 30 and 40 optionally absorb described energy, and different heat energy and different the regions arrow of difformity and size and arrow represent.

Non-channel region 30 represents the sensor measures temperature be used on skin, and this skin is positioned at the top of heart 32 anatomically.The arrow 34 of white represents the heat energy in heart 32.Non-channel region 30 comprises heart 32 and stores various blood vessel and branch 36a, 36b, 36c, 36d of heat energy.

The heat of different content is transferred, and the different temperatures measured depends on the anatomical structure of position and blood vessel 36a, 36b, 36c.Blood vessel is from trunk 34a branch on a large scale.Non-channel region 30 also comprises heat absorption structure 37, such as skeleton and muscle, and the heat energy 34 from heart 32 must stride across these structures, to arrive skin 39.Non-channel region 30 also comprises the indefinite fatty tissue of the number of plies 38, and it absorbs heat energy further.Owing to there is fat 38, the amount of thermal energy arriving skin surface 39 reduces, and this represents with arrow 36d and 36e, and wherein arrow 36d has the temperature higher than arrow 36e.Non-channel region 30 also comprises thick skin 39, has the stream low in calories represented with arrow 36f.

Thick skin 39 corresponds to the skin of chest, and fat deposit 38 is corresponding to the fat of various content that there is chest.Arrow 36g represents disorderly with the integrated radiant emittance reduced, and stride across the interference component of non-channel region at described heat energy after, this radiant energy is passed, and interference component comprises thick interface and heat absorption structure.In addition, BTT20 does not have the fat deposit being present in non-channel region 30 and 40.Lack thick interface such as thick skin and fat, lack heat barrier as fat, and disappearance heat absorption element such as muscle, making can emitted radiation uninterruptedly at BTT end.Lack thick interface such as thick skin and fat, lack heat barrier as fat, and disappearance heat absorption element such as muscle, making can emitted radiation uninterruptedly at BTT end.

All right reference diagram 2, the sensor on the skin of non-channel region 40 representative arm 42 carrys out measuring tempeature.Some is similar for transfer of heat in non-channel region 40 and non-channel region 30, and wherein final result is integrated radiant emittance that is disorderly and that reduce, and this radiant energy does not represent the temperature of the inner other end.Blood vessel branch widely from trunk 44a.Heat energy in blood vessel 46a, 46b, 46c is different from region 36a, 36b, 36c with temperature.The structure that heat energy 44 must stride across to arrive skin is also different from non-channel region 30.The total amount of heat absorption structure 47 is different, and therefore, when compared with non-channel region 30, the final temperature of non-channel region 40 is also different.The content of fat 48 is also different, and at region 46d and 46e, fatty change temperature, wherein region 46d is darker than region 46e.Thick skin 49 also reduces heat stream and the temperature of region 46f.When compared with radiant energy 36g, the reduction of the radiant energy represented with arrow 46g is normally very different, therefore, according to different human body regions, measures different skin temperatures.This is applied to the extracutaneous whole human body skin surface except BTT end.

The clinical correlation of the measured value of internal temperature such as rectal temperature is different from brain measured value.In laboratory conditions, demonstrated in a large amount of mammal species and optionally cooled brain, certain methods can be applicable to people.Such as, bladder is very different from the temperature of brain with intrarectal temperature.High temperature in brain and low temperature can not be reflected in the temperature measured by other intracorporeal organs.

Fig. 2 B is the transversal schematic diagram of head part 9, display brain 10, spinal cord 10a, the passage 20 represented by superior ophthalmic vein, cavernous sinus 1 and various adiabatic obstacle 2,2a, 3,4,4a, 4b, 5, cavernous sinus 1 is the thermal energy storage room of brain, and brain is remained completely adiabatic structure by adiabatic obstacle.Adiabatic obstacle comprise corresponding to scalp skin 2, correspond to the skin 2a covering face, the fat 3 on the whole surface covering skull and face, skull 4, spine 4a around spinal cord 10a, cover facial bone 4b and the cerebrospinal fluid (CSF) 5 of face.The combination thickness of the obstacle 2,3,4,5 of isolated brain reaches 1.5cm-2.0cm, and this has suitable thickness, is the maximum single obstacle of isolated environment in whole human body.Due to this complete confined environment, brain can not remove heat effectively, and thermal loss occurs with extremely low speed.Skin 2 corresponds to scalp, and scalp is the skin and the dependency structure that cover skull, and heat conductivity is poor, is an insulator.Fatty tissue 3 absorbs most far infrared wavelength, is heat buffer.The heat conductivity of skull 4 is poor, CSF as physiological buffer, not producing heat.

The heat generated in brain with accretion rate corresponds to 20% of the total amount of heat of being produced by human body, and the heat of this enormous quantity is maintained in the space of restriction and heat-seal.Cerebral tissue is the most easily by the tissue of heat energy induced damage, comprises the damage of being induced by high level and low-level heat energy.Due to brain fever insulation, and brain can not obtain or loses heat on physiology, the state of hypothermia (cold) and hyperpyrexia (sweltering heat) can cause brain injury, and secondary is dead rapidly, except showing effect with except death in patient due to excessive heating, every year in thousands of healthy individuals generation brain injury and death.There is provided except by continuous monitoring brain temperature and suitably and timely remind, the people of the hot disturbing influence of any cold-peace of catching cold has the danger of the brain injury of received heat induction.

Fig. 2 B also shows very little inlet point 20a, is less than 0.5% of body surface, corresponding to the end of the passage 20 of skin 2b.Skin 2b is very thin, thickness be 1mm or than skin 2 and 2a thinner, skin 2 and thicker than skin 2b five times or thicker of 2a.

Passage 20 from cavernous sinus 1, be cerebral veins, venae cerebri ejection and at channel end 20 with the pipeline of radiant energy heat transfer.Passage 20 provides a kind of Wheelchair Accessible leading to cavernous sinus 1, and cavernous sinus is positioned at the centre of brain, directly two calorie sources and brain is contacted: 1) produce due to brain accretion rate and the heat energy transported by Venous system; With 2) by artery supply, be delivered to the heat energy brain from other this part of human body.Direct contact distribution is shown in fig. 2 c in detail, and Fig. 2 C is the coronalplane of Fig. 2 B of the line corresponding to labelling " A ".

Fig. 2 C is the coronalplane by cavernous sinus 1, and cavernous sinus is chamber spline structure, has multiple space 1a be full of from vein 9 and the venous blood from superior ophthalmic vein 6.Cavernous sinus 1 is collected from cerebral tissue 7, heat energy from left and right internal carotid artery 8a, 8b and the venous blood from vein 9.Structure 7,8a, 8b, 9 all arrange also close contact with it along cavernous sinus 1.The special characteristic making the cavernous sinus 1 of passage become the standard of very useful thermal perturbation is closely combined with carotid artery 8a, 8b.Carotid artery carries the blood from human body, and the heat content being delivered to brain by described blood vessel can produce hypothermia or Hyperthermic state.Such as, when being exposed in cold, human body turns cold, and the cold blood from human body is carried in brain by internal carotid artery 8a, 8b, and cavernous sinus 1 is the inlet point that these blood vessels 8a, 8b enter brain.

As long as the blood of low temperature arrives cavernous sinus 1, corresponding thermal energy state is transferred to the skin surface of passage and channel end, thus before the blood of low temperature distributes in whole brain, provides a warning immediately.This is also applicable to the situation such as producing warm blood in motor process, and athletic meeting causes the heat generating higher than baseline 20 times.The heat carried by blood vessel 8a, 8b is transferred in cavernous sinus 1, can be detected at channel end.In addition, the heat energy that brain generates is carried by cerebral veins, venae cerebri blood, and cavernous sinus 1 is the structure being full of venous blood.

Fig. 3 A is the thermal infrared images of face, and the geometry of the channel end wherein on skin is manifested.Bright white point describes the central area of passage.Fig. 3 B is the schematic diagram of the exemplary geometric of the skin surface of channel end.The inboard portion 52 of passage 50 is circular.Side 54 is close to the caruncula 56 of edge, upper eyelid 58 and eyes 60.Passage extends in upper eyelid 62 from endocanthion district 52 so that angle sample is outstanding.

The interior zone of passage 50 comprises general areas and the Primary Entry Point of Primary Entry Point, as shown in Fig. 4 A-5D.Fig. 4 A is the thermal infrared images of face side, total figure of the Primary Entry Point of display brain temperature passage, is revealed as the bright white point being positioned at centre, endocanthion angle and top.Fig. 4 B is the figure of relation of the display general areas 70 of Primary Entry Point and itself and eyes 60, endocanthion angle 61, eyebrow 64 and nose 66.Interfering component in the general areas 70 of Primary Entry Point is more less than the outer peripheral areas of passage, provides the region of more reliably reproducing brain temperature.

Fig. 5 A is the thermal infrared images in the front of the face closing right eye, and the Primary Entry Point of display brain temperature passage, is revealed as the top at endocanthion angle and middle bright white point.Eyes are closed, and easily observe the skin that radiant energy only comes from BTT end.

Fig. 5 B is display Primary Entry Point 80 and the figure with the endocanthion angle 61 of the eyes 60 closed and the relation of eyelid 62 thereof.Have minimum interfering component due to region 80 and be present on proprietary identical anatomical location widely, the Primary Entry Point 80 of passage provides the region of the most reliably reproducing brain temperature.Primary Entry Point 80 has maximum integrated radiant emittance, and has the surface of most high emissivity.Primary Entry Point 80 is positioned on the skin of the upper part in endocanthion district 63, in the upper inboard portion at endocanthion angle 61.

Fig. 5 C is the thermal infrared images of the face side of Fig. 5 A, and left eye is closed, and the side view of the Primary Entry Point of display brain temperature passage, is revealed as bright white point.Eyes are closed, and can observe the skin that radiant energy only comes from BTT end.

Fig. 5 D shows the Primary Entry Point 80 in the upper part in the endocanthion district above endocanthion angle 61, and also shows the position of Primary Entry Point 80 relative to eyes 60, eyebrow 64 and nose 66.Sensing device can accurately be placed in above passage Primary Entry Point by supporting construction, because Primary Entry Point delimited with anatomic marker completely.In a word, sensor to be positioned in above endocanthion angle and in the corner of the eyes of contiguous eyes on skin area.Although indicant can be placed in supporting construction, so that the arrangement of guiding sensor better, the ubiquity of various lasting anatomic marker makes it possible to be settled accurately by non-technical personnel.

Primary Entry Point is the optimum position by supporting construction placement sensor, but by any position of sensor placement at channel end, comprises inlet point region substantially and peripheral region, provide that depend on application, useful clinically measured value.Degree of accuracy needed for measurement will determine the arrangement of sensor.When neurosurgery, operation on vessels of heart or other be in the operation process of hypothermia or pernicious Hyperthermic highly dangerous patient, the optimum position of sensor is Primary Entry Point.Heating in amateurish or occuptional movement, military affairs, workman, family is detected, wrinkle resistant etc. under sunlight, sensor placement can both be provided in any part of passage area the degree of accuracy needed for Clinical efficacy.

According to the present invention, the schematic diagram of Tu6Shi face, the general areas of the Primary Entry Point of display channel 90 and the whole region of channel end and the relation with corner of the eyes internal ligament 67 thereof.Channel end comprises Primary Entry Point region 90 substantially and upper eyelid district 94.Region 90 has periphery 92.Liang Ge endocanthion district has corner of the eyes internal ligament, and left eye is used for facilitating graphic extension.Corner of the eyes internal ligament 67 appears in the endocanthion angle 61 of eye 60.The corner of the eyes internal ligament 67 on the left side is directly relative with the corner of the eyes internal ligament of right eye, represents, with dotted line 61a from canthus, inner side 61.Although Primary Entry Point is above corner of the eyes internal ligament 67, a part for the outer peripheral areas 92 of passage is below ligament 67.

Fig. 6 A is the schematic diagram of display two physiology passages.Upper figure shows the region corresponding to BTT10.Figure below display corresponds to the region of metabolic pathway 13, comprises upper eyelid district 13a and palpebra inferior district 13b, is shown as light blue region in fig. ib.For the concentration measuring chemical substance, integrated radiant emittance is not enforceable.The critical aspects of spectral measurement useful is clinically the signal from brain region, and reduce or eliminate interference component, main interference component is fatty tissue.By removing fatty tissue and the spectral signal from brain accepting to be carried by blood vessel, accurate clinical measures can be obtained.The sensor fixed by supporting construction can be modified the visual field having and completely or partially match with metabolic pathway 13, catches the heat radiation from described passage 13.

In order to determine the heat stability of passage area relative to environment change, carry out the hot challenge trial of cold-peace.Fig. 7 A and 7B is the thermal infrared images of exemplary tests, is presented at the face before and after cold attack.In fig. 7, face has the outward appearance brighter than Fig. 7 B, and the face color of Fig. 7 B is comparatively dark, represents that temperature is lower.Compared with the nose of Fig. 7 B, the nose in Fig. 7 A has the outward appearance of turning white completely, and the nose of Fig. 7 B has the outward appearance of turning black completely.Because there are arteriovenous circuit and the interference component of regulate body temperature in the region outside passage, comprise fat, the change of ambient temperature can reflect in this region.Therefore, the measured value of those non-channel regions of face reflects ambient temperature instead of real body temperature.The non-channel region of face and human body skin can change along with the change of environment temperature.The radiant energy of passage area keeps stable, and heat content does not change, and demonstrates the stability of the heat emission in BTT region.Only when brain temperature changes, the heat radiation of passage area just changes, and this provides the most reliable measured value of human body Quantity of heat.

Fig. 8 A and 8B is the thermal infrared images of the face of different experimenter, shows the passage manifested with the bright white point in endocanthion district.Although the change existed anatomically and race difference, physiology passage is present in all individualities at large.Fig. 9 A and 9B is the thermal infrared images of display channel, shows that the passage manifested with bright white point is present in animal equally, illustrates at this with cat (Fig. 9 A) and Canis familiaris L. (Fig. 9 B).

Preferred embodiment comprises the temperature sensor with the measured value process electronic component be arranged in paster sample supporting construction, this supporting construction by active sensor directly with brain temperature access sites above contact skin.Therefore, the perspective view of the preferred embodiment of the people 100 of supporting construction is worn in Figure 10 display, and this supporting construction is made up of the paster with the active sensor 74 be placed on the skin of channel end.People 100 lies on mattress 76, and mattress contains antenna 78.Wire 82 reaches controller unit 84 from antenna 78, and described controller 84 is communicated with device 88 by communication line 86.Exemplary means 88 is included in decoding in bedside or care station and display unit.Should be appreciated that controller unit 84 is except by except cable 86 communication, can also contain radio transmitting device, obtained signal wireless is sent to distant station (remotestation).The active telemetry systems of inductive radio frequency can use identical antenna 78 to shift energy and acknowledge(ment) signal.

Antenna 78 is installed in mattress, medicated pillow, bed frame etc. in moveable or permanent mode.Preferred embodiment comprises thin Flat aerial, and this antenna elastomeric polymer encapsulates, and is installed in mattress, and is not seen by user.Alternately, antenna can be placed into any region of surroundings thereof, such as, be placed on bedside cabinet (nightstand).

Antenna 78 and controller unit 84 work with receptor/interrogator.RF energy is transmitted in the microcircuit of paster 72 by receptor/interrogator antenna 78.This energy is stored, and is converted for the process of measured temperature with for the data from paster 72 are transferred to antenna 78.Once enough energy are transmitted, microcircuit produces measured value, and these data is transferred to receptor/interrogator antenna 78, processing said data in controller 84, further these data is transferred to device 88, for showing or transmitting further.Switch participates in the element obtaining sensing data (measured value of energy) in certain sequence, makes obtained before the signal transmission of noise is rich in activation and store the result be quantized.Therefore, two kinds of inherent incompatible processes are successfully coexisted, because they can not activate simultaneously.

When there is noise, the spectrum of the energy that " propagation " is transmitted by a certain way, realize RF can be connected on communication apparatus, this can increase redundancy to inherently transmission, and reducing another kind of transmission or noise are translated in transmission probability by receipts device/information device 78, this noise can make receptor/information device 78 transmit and show error message.This wireless transmission scheme can be realized with few activeleg.This modulation on purpose propagates transmission of power in spectrum, thus produces immunity to interference, and finally, this system can be produced by batch process, and therefore, cost is extremely low.

Owing to running the energy of sensor 74 from antenna 78 in paster 72, the microcircuit in described paster 72 is very faint and extremely faint.By method for designing, the size of paster 72 is minimized to extremely little size further, and all treatment elements that RF connects by this method for designing are placed on as in the controller unit 84 of receptor.RF communication scheme and be present in receptor/information device controller 84 to the control of sensor 74, receptor/information device is by commercially available battery or by AC electric current supply power.Therefore, RF communication scheme and the control to sensor 74 are directly controlled by the MCU of controller 84.The electric current be present in paster 72 is preferably independently (self-contained) completely.Sensor-based system 74 in paster 72 is preferably silicon chip microcircuit, except power adjustment circuit and digital state control, also containing supporting sensor, quantize to come the data of sensor, encode from the circuit needed for the data of radio frequency transmission and transmission data.Sensor, support circuit, RF power supply and communication are all stored on microchip mould (micro-chipdie), can set up circuit on a large scale and at low cost.The program is preferably used to passive device and active device.

Operating process is made up of two kinds of patterns, craft and automatic.In manual mode, operator starts this system as nursing staff, and the RF energy be radiated on the microcircuit of paster 72 is stored, and is converted in temperature taking process, and the data from BTT end are transferred to antenna 78.Once enough energy are transferred (within 1 second), microcircuit can be measured, and transfers data to antenna 78 receptor and controller 84, to be displayed on backlight (back-lit) LCD display of such as care station.Sound " too " expression data are received, can check.In automatic mode, under the frequency of adjustment in advance, this process is carried out automatically and continuously by query, and when reading exceeds the scope of specifying, siren is activated.Also adopt three-dimensional antenna, the three-dimensional that controller 84 carrys out search antenna is set, to guarantee to be connected continuously and correctly between antenna 78 with sensing device 74.Should be appreciated that sensor can modulate the RF energy of reflection.Therefore, energy will go to obtain measured temperature by trigger sensor, and then sensor will modulate the energy of reflection.The energy of this reflection and signal will be received by query device and as above be shown.

The present invention is also provided for the method monitoring biological parameter, and the method comprising the steps of: be fixed on by active sensor on human body; Produce electromagnetic radiation by a table apparatus, this device is fixed at least one in mattress, medicated pillow and bed frame; Signal is generated from described active sensor; Described signal is received by the device be fixed at least one in mattress, medicated pillow and bed frame; With the numerical value according to described signal determination biological parameter.

Be to be understood that, various external energy can be used to originate, such as electromagnetic coupled, comprises by electromagnetic induction coupling (electromagneticinductioncoupling) and the battery that recharges of the available Foreign agitator super capacitor from external charging.It is also understood that and can start sensor-based system from afar by ultrasound wave.

Figure 11 is the perspective view of another preferred embodiment, and the people 100 of supporting construction is worn in display in further detail, and this supporting construction is positioned on the skin of channel end, by having sensor 74 paster 72, emitter 71 and digital translation and controller 73 forms.People 100 wears the necklace as antenna 78, and the weight of necklace is as control unit and transmission unit 79.Solaode and/or special energy content of battery unit 79.Patient gets used to carrying Holter monitor card and hangs on neck with rope, and the patient therefore adapting to the system adopted at present will extremely adapt to the present embodiment.Be to be understood that, except necklace, various article comprise clothes and electric equipment can be used as receptor/interrogator, this performance is easily incorporated into above mobile phone, notebook computer, palm PC, the network articles for use be connected on Internet etc., therefore, patient can use its mobile phone/computer articles for use to monitor the brain temperature of self.

The preferred embodiment being presented at Figure 10 and 11 preferably to the patient of any operation, any patient that hospital receives, sanatorium with provide monitoring heating or temperature peak continuously on ambulance, to prevent the death that caused by hospital infection (Hospitalinfection) and injury.Hospital infection is the infection be subject in the while in hospital.In the U.S., hospital infection the fourth-largestly causes dead reason, causes every year more than 100,000 death, mainly occurs owing to failing to determine earlier heating or temperature peak.Due to 24 hours automatic monitoring temperature, the present invention can determine in time and treat infection.If there is the peak value in temperature, siren will be started.This makes it possible to determine and treat infection in time, thus the complication that prevention is dead or serious, such as septic shock, and septic shock occurs owing to being delayed the treatment of course of infection.In addition, described preferred embodiment provides the device of monitoring heating continuously at home, is included in the sleep procedure of child and adult.

Figure 12 A is the front view that the preferred embodiment of the people 100 of supporting construction is worn in display, and this supporting construction is made up of the paster 109 with indicatrix (indicatorline) 111, containing the active sensor 102 be placed on the skin of channel end.The preferred embodiment shown in fig. 12 provides transmitting device 104, blood processor 106, a/d converter 107 and sensing device 102, and they are connected on power supply 108 by flexible circuit 110.Such as, transport module comprises RF, sound or light.Figure 12 B is the side view of the resilient characteristic of the supporting construction shown in Figure 12 A, the microelectronics bag (microelectronicpackage) 103 on the right side of paster 109 is connected with the power supply 108 in the left side of described paster 109 by flexible circuit 110, and microelectronics includes transmitting device, blood processor and sensing device.Exemplary will be described in detail.

According to this for thermometric exemplary, the heat energy launched by BTT carrys out perception by temperature sensor 102 such as miniature critesistor, and sensor produces the signal representing the heat energy of institute's perception.Then, this signal is converted into digital information, and is processed by processor 106 with the standard process of detected temperatures.The exemplary acoustic systems measured for brain temperature comprises temperature sensor, input coupling circuit, signal processing circuit, output coupling circuit and output display circuit.The temperature sensor 102 (such as critesistor) be placed in the paster 109 on the skin surface in endocanthion district responds brain temperature change, and brain temperature change shows as a kind of DC voltage signal.

This signal is coupled in signal processing circuit by input coupling circuit, for the output valve of modulating oscillator, such as multi-frequency generator circuit, the piezoelectric system worked in audiorange or in this scope slightly high, agitator are the main compositions of signal processing circuit.The output valve of agitator is imported in amplifier, and amplifier is second main constituent of signal processor.

Amplifier increase carrys out the output level of self-oscillator, makes the output valve of signal processor be enough to driver output display circuit.According to the character of output display circuit, such as audio tweeter, visual light-emitting diode display or other possible display modes, export coupling circuit and be used for the signal from signal processing circuit to mate with output display circuit.For the output display circuit needing digital input signals, export the analog that coupling circuit comprises numeral (A/D) change-over circuit.DC power circuit is the important composition retained in signal processing module.In signal processing circuit, need DC power circuit to support the operation of agitator and amplifier.The embodiment of DC power circuit comprises superminiature DC battery, light sensation DC power supply or the combination etc. of both.Preferably miniature changer (transducer), signal processing electronic component, transmitter (transmitter) and power pack are dressed up special IC (ApplicationSpecificIntegratedCircuit) or separately as a kind of hybrid circuit or in conjunction with MEMS (micro-electromechanical system (microelectricalmechanicalsystems)) technology.

Thermistor voltage is imported in micro controller unit, namely in signal chip microprocessor, program installed in advance by this processor, thermistor voltage is processed into digital signal, this signal corresponds to the measured patient temperature at BTT position, and unit is degree Celsius (or a degrees Fahrenheit).Should be appreciated that and can use different programming schemes.Such as, sensor voltage is directly inputted in microcontroller, is converted to temperature value, then show on a display screen with temperature value such as 98.6 ℉.On the other hand, before being input in microcontroller by this voltage, process this voltage by digital converter analog (ADC).

After carrying out extra Signal Regulation, microcontroller output valve drives piezo audio (ultrasound wave) emitter.The digit pulse of piezoelectric emitter wireless transmission, software in the receiver module of radio alarm clock size can identify this digit pulse, and receiver module is by the temperature levels prior-warning device of microphone, low pass voice band filter, amplifier, micro controller unit, local Temperature displaying and preliminary election.Signal processing software is pre-programmed in the micro controller unit of receptor.Although the invention provides for the RF transmitting device when there is noise, having other advantages with microphone as the particular of receptor in hospital environment, it does not produce RF interference to other RF devices many be usually present in this environment.Micro controller unit drives the temperature indicator of every monitored patient.Every platform emitter marked himself ID.Therefore, a receiver module can be used for different patient.Be modified that there are micropkonic wrist-watch, mobile phone etc., can as receiver module.

In another embodiment, the output valve of microprocessor is used for driving pressure electric buzzer.Microcontroller output valve drives buzzer, and prompting user is in the state that health is on the hazard.In this design, the output valve of microprocessor is imported in digital analog converter (DAC), and the digital data conversion from microprocessor is become suitable analogue signal by this transducer, for driving buzzer.

Also having in another embodiment, from the output valve of (DAC) for driving speech synthesizer chip, this chip is programmed to export suitable audio frequency, and warning user is in the danger of heatstroke, such as athlete.For higher than the sense temperature of 39 DEG C, its information is " your fever.Find frescade.Drink cold drink.Have a rest ".For temperature lower than 36 DEG C, this information is: " your body temperature is low.Find and avoid cold sanctuary.Drink hot drink.Warm-up ".

In another embodiment, output valve is for driving optical transmitting set, and optical transmitting set is programmed to export suitable optical signal.Emitter has the infrared ray be activated when temperature reaches certain level.Optical signal, as remote control unit, activates the remote unit sounded the alarm.Such as, when child sleep at night there is temperature peak time, this embodiment can remind father and mother.

Exemplary for the platform of this locality report is formed by the electronic module be mechanically loaded in fabric or plastic supports (holder) by three, and such as paster 109, it contains the sensor 102 on the skin being placed in BTT position.Except battery, these modules are: temperature sensor module, micro controller module and output display module.Electronics separating surface is adopted, to make correctly to work between the modules of all devices.The structure of this system is made up of band, such as, by being attached to the paster 109 on BTT region from sticky pad (self-adhesivepad).The critesistor be coupled on microcontroller drives audio frequency piezoelectric emitter or LED.This system carries out this locality report, without the need to receptor to temperature.When running into specific threshold value, a kind of tone or light can remind user.This tone is as a kind of partials or the sound reproducing people.

Another exemplary for remote reporting is made up of four electronic modules: sensor assembly, microprocessor module, output transmitter module and receptor/monitor module.From the angle of machinery, in fact first three module is identical with first embodiment.From the angle of electronics, temperature sensor and microprocessor module are identical with embodiment above.In this embodiment, output transmitter module substitutes local output display module above.Export transmitter module to be designed to the temperature results determined by microprocessor module is wirelessly transmitted to receptor/monitor module at a distance.Use electronic interface between various modules, correctly to work.This device can for the patient of hospital or family.By reading the data provided by receptor/monitor module, continuous print basic temperature level can be obtained.

Various temperature-sensing element can be used as temperature sensor, comprise critesistor, thermoelectricity occasionally the heat and power system of RTD (resistance temperature detector), platinum filament, surface mounted sensor (surfacemountedsensor), quasiconductor, measured surface temperature, fluorescence optical fiber, bi-metal, expansion of liquids device and state changing apparatus (change-of-statedevice), heat flux sensor, crystal temperature effect measures and irreversible temperature indicant comprises liquid crystal Mylar sheet.Preferred temperature sensor comprises the 104JT type critesistor can bought from Japanese Shibaura.

Figure 13 shows structure chart emitter 120 being connected to the preferred embodiment on receptor 130 of the present invention.Emitter 120 preferably includes chip 112, this chip is except power supply 122, amplifier (A) 124, sensor 126 and antenna 128, assemble microprocessor (MCU) 114, radio frequency emitter (RF) 116 and A/D converter 118, be preferably fixed in chip.Exemplary chip comprises: (1) rfPIC12F675F, (can purchased from MicrochipCorporation, Arizona, USA), this is emitter (2) CC1010 of MCU+ADC+433Mhz, can purchased from the ChipconCorporation of Norway.

Except power supply 150 and I/O unit (I/O) 148 and relevant modem 152, optical transceiver 154 and communication part 156, receptor 130 preferably includes chip RF transceiver 132 (such as, CC1000 can purchased from ChipconCorporation), microprocessor unit (MCU) 134, amplifier and filter element (A/F) 136, display 138, clock 140, keyboard 142, LED144, speaker 146.

Can business purchase except available RF emitter chip except aforesaid, various device can be used in transmission plan.A simple transmitting device comprises the instrument of the single channel emitter with 916.48MHzb, and temperature reading is sent to the receptor of bedside with the frequency proportional with reading.Critesistor resistance will control the frequency of agitator, to RF emitter input data input values.If cycle of operation is lower than 1%, 318MHz wave band can be adopted.Except frequency, period measurement technology can be adopted.This model adopts single wireless electricity frequency carrier device as signal transmitter, and by this carrier signal of brain temperature modulates information deriving from conversion equipment, its electrical feature can be changed into the function of temperature by this conversion equipment (such as critesistor).Can by the frequency of temperature information modulated carrier signal or amplitude, the receptor making to be tuned to this frequency can the carrier signal that changing of demodulation, restores the temperature data of this slow change.

The another kind of transmission technology being suitable for the signal of the sensor transmitting in self supporting structure is linear frequency modulation device.When this device is activated, emitter outgoing carrier signal, this signal starts with the lower frequency in ISM wave band, and increases frequency at any time lentamente, until reach peak frequency.Brain temperature information is for revising the rate of change of chirped frequency.Receptor is designed to by finding two or more characteristic frequency, the very accurately input value of measure linear frequency modulation.When the first frequency being detected, clock measures the time of sharing, until receive the second frequency.Therefore, the third frequency, the 4th kind of frequency etc. can be added, to help to repel noise.Because in fact all direct frequency spread spectrum emitters and Frequency hopping transmissions device (frequencyhoppingtransmitter) are in they random dispersion in whole ISM wave band, they really generate the frequency of " correctly " order probability in orthochronous is very low.

Once receptor to measure between target frequency consuming time, this time is the numerical value that can represent brain temperature.If second, third or the 4th frequency of expection are not received by the receiver in " known " time window, this receptor will be abandoned initial input value as noise.This provides a kind of Spread Spectrum Systems, adopts wide spectrum to carry out transmission information, and in the mode of the expection noise being different from other user from ISM wave band to this information of encoding.Linear frequency modulation emitter with low cost, and easily assemble, brain temperature changer (transducer) is one of activation elements of controlled frequency rate of change.

For this locality report other preferred embodiments in addition to a power supply, also comprise sensor, operational amplifier (operationalamplifier) (LM358 purchased from NationalSemicondutorCorporation) and LED.Should be appreciated that operational amplifier (OpAmp) can substitute with MCU, and LED piezoelectric element substitutes.

Figure 14 is the schematic diagram of display support structure 160, and sensor 158 and MCU164 control and/or regulon 162.Communication between MCU164 and unit 162 is realized by wired 168 or wirelessly 166.As an example, instead of restriction, exemplary cell 162 comprises the seat, furniture, sports apparatus, clothes, footwear, medical treatment device, Teat pipette etc. of climate control unit in automobile, self-operated thermostatic controller, the vehicles.Such as, in sports apparatus, MCU164 is programmed and temperature levels is transferred to acceptor unit 162.MCU in sports apparatus unit 162 is programmed, according to the Signal Regulation speed generated by MCU164 and other settings.

Preferred embodiment makes accurately to settle sensor apparatus by the supporting construction on BTT position.Supporting construction is designed to match with the anatomic marker in BTT region, to ensure that sensor is correctly placed always.Canthus is considered to permanent anatomic marker, that is, in everyone, it is present on identical position.As the present invention confirm, BTT district is also permanent anatomic marker.Conveniently as one man be placed on BTT position, as shown in Figure 15 A-15E, the indicant in supporting construction can be used.

Figure 15 A shows the leading line 170 be placed on the outer surface of supporting construction 172.Leading line 170 aims at canthus 174, inner side.Sensor 176 is positioned at the top of leading line 170, and in the outer rim of supporting construction 172, the leading line 170 once supporting construction 172 aims at canthus 174, inner side, and sensor 176 is positioned on the Primary Entry Point of passage.Therefore, supporting construction can accurately and as one man be applied in a certain way, and sensor 176 is covered on BTT region always.

Figure 15 B shows the different designs of paster 172, has the identical leading line 170 aiming at canthus 174, inner side, although therefore design is upper different, as one man sensor 176 can be placed on BTT district.

Figure 15 C is another preferred embodiment, and interior angle 174 aimed at by display sensor 176.Therefore, in this embodiment, do not need leading line, sensor 176 itself has guided arrangement.

In Figure 15 D, the MCU175 of paster 172 and battery 177 are positioned at the outside at BTT position, and sensor 176 is accurately placed on BTT position.Should be appreciated that the indicant of any type that can utilize in supporting construction, correctly to settle in BTT district, comprise the otch in external label, foliation structure, supporting construction, aim at the different geometries etc. at canthus, inner side.

Figure 15 E is another preferred embodiment, and the top edge 176a of display sensor 176 aims at interior angle 174, be positioned at the below in endocanthion district, and microchip controller 175 is positioned at the top in endocanthion district.Supporting construction 172 has geometry indicant 179, is made up of the dolly dimple in supporting construction 172.The hardware that should be appreciated that the another side that the band that works as supporting construction is as contrary with sensor in cohesive bandage has and be made up of the sheet that can tear off.First the one side of sensor is attached on skin, and any unnecessary band is easily torn off.Two kinds of sizes, adult with child, comprise all possible user.

The material of the supporting construction worked with paster can be soft, and have as polyethylene the insulation characterisitic that has.Depend on application, the skin of paster from outside to inside of multiple structure comprises as follows: thin insulating barrier; Two-ply foam binding agent (polyethylene); Sensor (critesistor) and Mylar sheet.Sensor surface can cover Mylar sheet, then uses the viscosity side wrap of foam.The thin material with any softness of high thermal resistance and low heat conductivity is preferably used as the interface between sensor and outside, such as polyurethane foam (K=0.02W/m).Any supporting construction can combine preferred insulant.

Optimization power supply for paster comprises natural thermoelement disclosed by the invention.In addition, can use and adopt plastic composition if fluorobenzene thiophene (fluorophenylthiophenes) is as the frivolous plastic battery of standard of electrode, it is soft, makes it possible to construct according to the anatomy at BTT position better.Another kind of exemplary suitable power source comprises the ultra-thin solid state lithium battery of light weight, is made up of, about 300 micron thickness semisolid plasticity electrolyte (plasticelectrolyte).

This system has two kinds of patterns: under room temperature, and this system is static, and under body temperature, this system is activated.This system also has the switch of startup/closedown, utilizes skin resistance to produce circuit, so only when sensor is positioned on skin, this system is just activated.This paster also has a built-in switch, wherein divests conduction backing (backing), opens circuit (pad), start this system.In addition, when removing from human body, this paster is placed in the container (case) containing Magnet.Magnet in container as close switch, when this paster in a reservoir time, transmission is terminated.

Figure 16 A-16C is the schematic diagram of preferred embodiment, and the people 100 of the supporting construction 180 being assembled into paster has been worn in display.In the preferred embodiment shown in Figure 16 A, supporting construction 180 is containing LED184, battery 186 and sensor 182.Sensor 182 is positioned on the Primary Entry Point above the endocanthion district being adjacent to canthus 25, inner side.According to principle of the present invention, when signal reaches certain threshold value, LED184 is activated.Figure 16 B is another preferred embodiment, and the people 100 of supporting construction 180 is worn in display, and sensor 180 is positioned in the general areas of the Primary Entry Point of passage, and the top edge 181 of supporting construction 180 aims at canthus 25, inner side.Supporting construction 180, containing an extension, is laid on cheek region 189, is equipped with for the discharger 183 of wireless transmission, blood processor 185 and power supply 187.Figure 16 C is the exemplary preferred embodiment that the people 100 of two laminated structure 180a is worn in display, this laminated structure is made up of supporting construction 180b and filling structure (housingstructure) 180c, connected by wire 192, preferably flexible circuit.Supporting construction 180b contains the sensor 182 be positioned on BTT position.Filling structure 180c comprises the adhesive tape on forehead 21, is loaded with blood processor 183a, discharger 183b and power supply 187, transfers signals to unit 194 as mobile phone.

Figure 17 is the schematic diagram that display has another preferred embodiment of the supporting construction 180 of sensor 182, and this supporting construction is fixed on nose 191 by clip 196.Supporting construction 180 extends up to forehead 193.The filling structure 195 of supporting construction 180 contains pressure attachment device, as clip 196.Filling structure 197 on forehead is containing discharger and power supply.Clip 196 adopts the structure 196a based on spring, applies soft pressure and supporting construction 180 and sensor 182 is fixed on stable position.Filling structure 197 can also contain LCD display 19.LCD19 has the Inverted Image that user carries out observing in mirror, and in addition, LCD19 has hinge or can be folded correctly to settle, and makes user easily observe shown numerical value.

Figure 18 is the perspective view of another preferred embodiment, and the people 100 of the supporting construction 180 be made up of paster is worn in display, and sensor 182 is positioned on the skin of channel end, is connected on decoding and display unit 200 by wire 199.Supporting construction 180 has the visual indicator 170 of aiming at canthus 174, inner side.Wire 199 comprises adhesive tape 201 on its first 20cm, is most preferredly connected to adhesive tape on wire 199 before the wire carrying out sensor 182 on 10cm.

Figure 19 A1-19D is the preferred geometry of supporting construction 180 and sensing device 182 and the schematic diagram of size.For best-of-breed functionality of the present invention, the sensor of specific geometry and size and supporting construction are necessary.Formulate the size of supporting construction 180 and design, with optimizational function and with the geometry of the different piece of passage and consistent size.

Figure 19 A1 shows the supporting construction 180 as paster.Paster 180 is containing sensor 182.Paster 180 or may be only sensor 182 containing other hardware.Illustrative sensors 182 is thermoelectric sensors that flat critesistor or body surface are placed.The preferred maximum dimension of paster is referred to as " z ", is equal to or less than 12mm, is preferably equal to or less than 8mm, and be most preferably equal to or less than 5mm.Outer peripheral minimum range from the outward flange of sensor 182 to paster 180 is referred to as " x "." x " is equal to or less than 11m, is preferably equal to or less than 6mm, and is most preferably equal to or less than 2.5mm.For illustration of property object, sensor 182 has different sides, and distance " y " corresponds to the outer peripheral ultimate range from the outward flange of sensor to paster 180.Although have different sides, minimum range " x " is the determiner of preferred embodiment.Should be appreciated that adhesive coverage can be used in the whole surface of sensor 182, therefore between sensor and the outward flange of supporting construction, there is no spacing.

Prepared by the exemplary Mylar comprising the skin at the surface contact BTT position of sensor.Mylar surface comprises sensor itself, and the surface of its contact skin has binding agent.In this case, supporting construction comprises a slice glue or binding agent, can relative to the concordant structure of sensor itself.Therefore, in Figure 19 E, the sensor 182 that supporting construction 171 is fixed by a slice glue forms, and juxtaposition is in BTT district.Sensor 182 comprises Mylar, critesistor, thermocouple etc., sensor 182 is preferably at the edge of supporting construction 171 as a slice glue or any supporting construction, and described sensor 182 preferably also insulate at its outer surface with a slice insulant 173 further, such as polyethylene.

As shown in Figure 19 A2, sensor 182 has binding agent on its surface, to be fixed on skin 11.Then, according to principle of the present invention, by this sensor application on BTT position.Preferred distance " x " is equal to or less than 2.5mm, make accurately sensor 182 to be placed on the Primary Entry Point of passage best, thus signal can be obtained best, this is used to need in the application of the most accurate measured value, such as, in the process of monitoring operation technique.Although paster can be used as the supporting construction that preferred size describes, should be appreciated that according to principle of the present invention, identical size can be applied in any supporting construction, comprises clip, endocanthion pad, the ornaments etc. worn.

Figure 19 B is the exemplary of the circular patch 180 with applanation sensor 182.Preferred size " x " and " z " are applied in Figure 19 A1 in the same manner.Figure 19 C is the exemplary of the paster with pearl type sensor 182.Preferred size " x " and " z " are applied in Figure 19 A1 in the same manner.Figure 19 D is the exemplary with sensor-chip 15.Sensor chip 15 comprises the part that sensor is integrated into chip, such as special IC (ASIC).Such as, sensor chip 15 comprises sensor 15a, processor 15b and emitter 15c.Preferred size " x " is applied in Figure 19 A1 in the same manner.Other hardware such as power supply 27 can be loaded in supporting construction 180, and supporting construction has the large scale being referred to as " d ", as long as keep size " x ", size " d " does not affect its performance.

Supporting construction and sensor are modified and match with the geometry of passage and size, and carry out contact measurement or non-cpntact measurement, wherein sensor does not contact the skin at BTT position.

Figure 20 A-20C shows according to preferred size of the present invention " x ".As shown in FIG. 20 A, the outer peripheral distance from the outward flange 180a of supporting construction to sensor 182a is 11mm.Preferably, as shown in fig. 20b, the outer peripheral distance from the outward flange 180a of supporting construction to sensor 182a is 6mm.Most preferably, as shown in Figure 20 C, the outer peripheral distance from the outward flange 180a of supporting construction to sensor 182a is 2.5mm.

Sensor 182 is displayed in Figure 21 A and 21B relative to the optimum position at canthus, inner side 184.Supporting construction 180 placement sensor 182, aims at canthus 184, inner side (Figure 21 B).Preferably, as illustrated in fig. 21, sensor 182 is placed in the top at canthus 184, inner side by supporting construction 180.

Under the preferred embodiment being assembled into the supporting construction of paster and clip is preferably used to hospital environment and health care place, comprises monitoring heating or temperature peak continuously.The supporting construction being assembled into endocanthion pad or wearing ornaments is preferred for monitoring hyperpyrexia, hypothermia and amateur, professional athlete, soldier, fireman, the hydration status of builder and other high strength occupations, occupational safety, and the wrinkle that the hot injury for preventing due to sunlight causes is formed.

Figure 22 A-22C is the perspective view that the preferred embodiment of the people 100 of supporting construction is worn in display, and this supporting construction is assembled into the endocanthion pad 204 of glasses 206.In the preferred embodiment shown in Figure 22 A, endocanthion pad 204 is containing sensor 202.Endocanthion pad 204 is connected on spectacle frame 206 by linking arm (connectingarm) 208, adjacent with conventional nose pad 212.Sensor 202 is positioned in the top in the endocanthion district at adjacent medial side canthus 210.

Figure 22 B is the exemplary preferred embodiment that the people 100 of the supporting construction being assembled into endocanthion pad 204 is worn in display, and sensor 202 is integrated in the special spectacle-frame 216 built, containing LED228,230.Build the brace 220 connecting the rims of the lens 222 on the left side and the rims of the lens 224 on the right, and be placed in than on the rims of the lens 222 of conventional eyeglass structure, 224 higher positions.The ad hoc structure of the higher and picture frame 216 in the position due to brace 220, the top edge at left-side lens edge 222 is positioned on the position slightly higher than eyebrow 226.This structure makes endocanthion pad 204 be positioned on BTT position, and LED228,230 aims at visual axis.The arm 232 of endocanthion pad 204 can be elastic and adjustable, for correctly sensor 202 being placed in the skin at BTT position, for not needing to remove from BTT position when measuring.LED228 is green, and LED230 is red, and when signal reaches certain threshold value, described LED228,230 is activated.

Figure 22 C is the schematic preferred embodiment that the people 100 of supporting construction is worn in display, and supporting construction is assembled into the endocanthion pad 204 with sensor 202.Carry out the signal 202 of sensor by emitter 234 wireless transmission be loaded in leg of spectacles 236.Receiving element 238 receives the signal from emitter 234, for the treatment of and display.Exemplary receiver unit 238 comprises wrist-watch, mobile phone, pager, palm PC etc.

Figure 23 A-23B display is assembled into the perspective view of the alternative embodiment of the supporting construction of the nose pad 242 of the glasses 244 of improvement.Figure 23 A shows the perspective view of glasses 244 containing the nose pad 242 improved, and the power supply 248 having sensor 240 and processor 241, perspiration sensor 246 and fixed by leg of spectacles 250, and the emitter 252 fixed by leg of spectacles 254, all these are electrically connected.The super-huge nose pad that the nose pad 242 improved has sample extension, angle 243 by top forms, and is arranged on channel end by sensor 240.

Figure 23 B is the schematic diagram of the glasses 256 of the nose pad 258 of display containing super-huge improvement, has sensor 240, the perspiration sensor 260 fixed by leg of spectacles 262, the emitter 264 fixed by leg of spectacles 266.According to size of the present invention and principle, the 12mm or wider of 258a above it preferably measured by the super-huge nose pad 258 of improvement, contains sensor 240 at its outward flange.

As shown in Figure 24, another preferred embodiment of the present invention, provides the protective eye lens 268 of fixing endocanthion pad 260, is suitable for sensor 262,264 to be placed in the access sites of skin.As shown, protective eye lens 268 goes back constant transmissions device 261, power supply 263, local annunciator 265 as LED and the antenna 267 for remote reporting.Antenna 267 is preferably integrated into a part for the rims of the lens 269 of protective eye lens 268.

As shown in Figure 25, in endocanthion pad 272, other and the device of the signal correction generated by sensor 270 comprise on and off switch 274, represent mould selects the configuration switch 276 of device, emitter 278 for the wireless transmission of signal, speaker 282, piezo-electric device 283, input equipment 284 and blood processor 286.Any part preferably by spectacle-frame 280 fixes device 274,276,278,282,284 and 286.Should be appreciated that except the wire for wire transmission signal, various device, switch and data, the control device of time and other multifunction switchs can be stored can be assembled in instrument.

Figure 26 A shows the rearview by the preferred embodiment of the fixing sensor 299,300 of the endocanthion pad 290,289 of glasses 292, except the rims of the lens 293 of emitter 288, perspiration sensor 294 and the wire 296 be disposed in leg of spectacles 295 and described glasses 292, also comprise rims of the lens 297 and display 298, be connected in display device 296.

Figure 26 B is the front view of glasses 292, and these glasses comprise the rims of the lens 293 of perspiration sensor 294, emitter 288 and the wire 296 be disposed in leg of spectacles 295 and glasses 292, are connected in display device.In this embodiment, perspiration sensor 294 produces the signal (sodium ion of such as 9mmol/L) of the concentration of the material in instruction perspiration, be displayed on the display 296 in left side, the sensor 300 fixing by endocanthion pad 290 produces a signal, the brain temperature of instruction such as 98 ℉, is displayed on the display 298 on right side.Perspiration sensor can be porous or micropore, makes when measuring chemical composition, optimizes liquid and passes through sensor.

Various display device and the associated lens for correctly assembling can being adopted, comprising liquid crystal display, LED, optical fiber, microprojector, determination of plasma device etc.Should be appreciated that display device can be directly attached on lens, or the major part of lens.It is also understood that display device can comprise the separate section be included in rims of the lens or outside rims of the lens.In addition, two lens and the display 296,298 kept in rims of the lens 293,297 can be replaced with single unit, and when using or do not use rims of the lens 293,297, this single unit can be directly attached on the framework of glasses 292.

Figure 27 is the perspective view of another preferred embodiment, shows three supporting constructions 304, preferably provides the endocanthion pad brace being modified and being used as interchangeable brace.This embodiment comprises three sheets.Sheet 301 comprises left-side lens edge 301a and left side leg of spectacles 301b.Sheet 302 comprises right-side lens edge 302a and the right leg of spectacles 302b.Sheet 303 is referred to as endocanthion sheet and connects, and comprises the cross structure of the mat structure 303b of glasses 303a and glasses.Pad 303 is modified to provide endocanthion pad 306 especially, is placed on BTT position by sensor 308.With reference to the present embodiment, user can be bought according to three glasses of the present invention, and wherein adapter 303 has sensing function, and therefore, cost is lower.But three glasses 304 provide and substitute adapter 303 without sensing function with the adapter 303 with sensing function.As shown in Figure 27, the adapter 303 with endocanthion pad 306 and sensor 308 also comprises radio frequency emitter 301 and battery 312.Therefore, adapter 303 provides all required hardware, comprises the device for sensing, transmission and report signal.Any attachment device known in the art can be used, and comprises pressue device, carriage, safety pin etc.

As depicted in fig. 28 a, another preferred embodiment provides the moveable endocanthion sheet 314 of placement sensor 316.As shown, the cross structure 320 of glasses 318 is connected on endocanthion sheet 314 in a removable manner.Glasses 318 also comprise the perspiration sensor 322,324 fixed by forward part 311 and the discharger 326 fixed by leg of spectacles 313.The forward part 311 of glasses 318 is defined as forehead portion and extends through the forehead of wearer, containing perspiration sensor 322,324.The film of perspiration flows through sensor 322,324, arrives electrode, produces the electric current proportional with the content of the analysis thing be present in perspiration.

Figure 28 B is the rearview of moveable endocanthion sheet 314, display of visually annunciator 323,325, green LED such as in left arm and red LED, and be modified the sensor 316 that is placed on channel end, and for the wire 326 of the left arm 329 and right arm 328 that are electrically connected endocanthion sheet 314.The front view of the moveable endocanthion sheet 314 of Figure 28 C, power supply 330, emitter 332 and sensor 316 in display left arm 329, and for the wire 326 of the left arm 329 and right arm 328 that are electrically connected endocanthion sheet 314.Endocanthion sheet 314 can substitute with the conventional nose pad of not sensing, and this nose spacer has the size identical with endocanthion sheet 314 and size, fully identical with the cross structure 320 of the glasses 318 with Figure 28 A.Moveable endocanthion sheet, except LED, also has the built-in LCD display for showing numerical value and/or RF emitter.Therefore, moveable one or more annunciators of endocanthion sheet, are integrated into single sensing and reporting unit.

Figure 29 is the rearview of the preferred embodiment of the supporting construction of the clip structure 340 being assembled into glasses, comprise attachment device 338 as hook or Magnet, transmitting device 342, blood processor 344, power supply 346, be assemblied in be correctly positioned in the endocanthion pad 348 on BTT position in the rotating structure 349 of three axles, and sensor 350.Clip structure 340 is modified to be assemblied on conventional eyeglass, endocanthion pad 348 is fixed on the top of the nose pad of conventional glasses.

The endocanthion pad of sensing is preferably connected on attaching structure, as glasses, does not rely on the existence being assemblied in special connection on described glasses or attachment device, such as groove, safety pin etc.This embodiment is provided in the means of the endocanthion pad widely using sensing in the attaching structure of all kinds or brand.Figure 30 shows the front view of endocanthion pad 352, comprises viscosity backing 354, pad 352 is fixed to attaching structure as on glasses or in another supporting construction.Tacky surfaces 354 is modified to match with glasses area, is fixed to by endocanthion pad 352 on described glasses, and this area is as corresponded to the area of the conventional nose pad of glasses.Endocanthion pad 352 works with completely independently unit, and containing sensor 356, power supply 358 and annunciator 360, be electrically connected by wire 361,362.Annunciator 360 comprises with visual device (such as LED), and (sound chip of such as piezoelectricity or speaker carry out this locality report to audio devices, and carry out remote reporting by wireless transmission.

Figure 31 A is the top end view of the alternative embodiment of the supporting construction being assembled into glasses 380, and these glasses have hole 364,365 in conventional nose pad 366,376, for fixing special endocanthion pad.Glasses 380 comprise the wire 368 in the right-side lens edge 371 of the framework being disposed in glasses 380, are connected on nose pad 366 by the emitter 370 be loaded in the leg of spectacles 369 of the right with described wire 368.Glasses 380 also comprise the wire 363 be assembled on left-side lens edge 365, are connected on nose pad 376 by the emitter 372 be assemblied on left side leg of spectacles 374 with described wire 363.Figure 31 B is the enlarged perspective of the part of supporting construction 380, in conventional nose pad 376, have hole 365.Figure 31 C is the lateral plan of the conventional nose pad 366 of porose 364.Figure 31 D is the lateral plan of the endocanthion sheet 382 be mounted in the hole 364 of conventional nose pad 366.

Figure 32 A is the perspective view of the people 100 wearing the supporting construction comprising cap 390 in the corner of the eyes, and in the corner of the eyes, cap is fixed on above the nose pad 392 of conventional glasses 394.Figure 32 B is the perspective back view of cap 390 in the corner of the eyes, display sensor 396, emitter chip 398 and for cap 390 being fixed on the opening (opening) 397 on nose pad.

Figure 33 A is the perspective view being fixed on cap 390 in the corner of the eyes on nose pad 392.In the corner of the eyes, cap 390 is containing sensor 396, emitter chip 398 and opening 397.Figure 33 B is the perspective view that in the display corner of the eyes, cap 390 is fixed to institute's end product on nose pad 392

The invention provides specific nose pad, sensor is correctly placed on BTT position.Figure 34 is the perspective view of the rotatable nose pad 400 in left side improved, nose pad is modified sensor placement on the skin of channel end, comprise the box body (house) 406 of nose pad 402, arm 404 and loading actuating device (gear) with sensor 401, this actuating device makes it possible to as rotating disk, rotate nose pad, is confirmed as in the different passage area of 1 and 2 to be placed in by sensor 401.Sensor is placed on endocanthion angle by position 1, and close to the general areas of passage Primary Entry Point, sensor is placed on just in time above the endocanthion angle at passage Primary Entry Point place by position 2.This embodiment makes it possible to automatic activation sensor-based system, and utilizes the fact that the temperature of the bridge of the nose as seen in Fig. 1 (nose is black) and Fig. 2 (nose is purple and blueness) is low.When pad be in its static position (" zero ") upper time, it is that the low-temperature level of 35.7 DEG C is set up, corresponding to the rotine positioning of the nose pad on nose that sensor remains on temperature.When position " zero ", sensor is in sleep pattern (temperature of 35.8 or lower).Sensor is moved to the region of heat, as general areas (position 1) or Primary Entry Point (position 2), automatically activated sensors, enters activation mode and starts sensing function.

Be to be understood that, according to principle of the present invention, numerous special nose pads and endocanthion pad can be used, comprise the axle pivot hinge chain enabling pad completely or partially folding, use the self-regulation pad etc. of spring, axle pivot, slide plate in the trench, and the self-regulation device of not agnate anatomical variations can be adapted to.Should be appreciated that most preferably by be connected to rims of the lens upper part or in the 6mm from the top edge of rims of the lens, the nose pad of improvement is preferably placed on spectacle frame on high highland.

Various material can be used, comprise the material with super viscosity, closely by sensing device juxtaposition on BTT position.The various metal wire with super-elastic property characteristic is used as hinge means, to be correctly placed on BTT position by sensing device.Endocanthion pad can be prepared with soft synthetic resin material, and such as silicone rubber, conductive plastics, conductive elastomeric material, metal, pliable material etc., to be correctly arranged on the BTT position in endocanthion district, realize suitable function.It is also understood that endocanthion spacer has the elastic characteristic of applicable mold pressing, comprise when by the material of stressed shape be still in during weight when removing pressure.The rubber, silicones etc. with any type of shape memory also can be used in the nose pad of endocanthion pad and improvement.

By reducing or eliminating interference component in a large number, high signal noise ratio is provided, improve sensor to catch the heat radiation from BTT, the invention provides the device accurately and accurately measured needed for biological parameter, comprise the chemical composition measured as infrared light spectroscope (infraredspectroscopy) with Optical devices in body.And the instruments and methods by enhancing signal of the present invention, makes it possible to by various technology and uses dissimilar electromagnetic radiation, obtaining reading useful clinically.Except nearinfrared spectroscopy, when the other forms of electromagnetic radiation of employing is as intermediate infrared radiation, radio wave impedance, photoacoustic spectroscopy, Raman spectroscopy, visible spectroscopy, ultraviolet spectroscopy, fluorescence spectroscopy, scattering spectroscopy and polarized light optical rotation, and other technologies such as fluorescence (comprising Maillard reaction, light induced fluorescence and ultraviolet induction glucose fluorescence), colorimetric, refractive index, luminous reflectance, thermal gradient, the total internal reflection slackened, molecule are engraved on one's mind, present invention obtains good result and higher signal noise ratio.Be modified the sensor of catching heat energy in BTE (brain fever energy) access sites and provide the best means using calutron to measure biological parameter.BTE passage is the physical equivalents of physiology BTT, is used at this physical characteristic characterizing passage.The geometry of BTT and BTE passage on skin and size are identical.

The following feature of BTE passage makes it possible to obtain signal best.The skin of BTE channel end is very thin.If skin is thick, so radiation can not penetrate and arrive measured material.The skin of BTE passage as one man has constant thickness over its entire surface.The skin being present in any thickness on other skin areas makes to obtain required accuracy.BTE passage does not have fat.The intensity of the signal being reflected and transmit alters a great deal between different patient, depends on individual corporal characteristic, such as fat content.The blood vessel of BTE end is very shallow, is tail vein and does not have arteriovenous circuit.On other partial skins, deep-level blood vessel location is very dark, and between different people, its position and the degree of depth all alter a great deal.BTE passage covers its end without light-scattering component, such as skeleton, cartilage etc.Heat radiation need not pass cartilage or skeleton, to arrive measured material.But the BTE channel end on skin has specific fixing geometry, delimits fully with permanent anatomic marker.On other skin surfaces of human body, the discordance between calorie source and the position of detector is error and variable important sources.

After in described transmitting interaction and by measured material absorbing, far infrared radiation spectroscope is measured natural heat and is launched.The invention provides a kind of thermally-stabilised medium, can the interference component of negligible number and thin skin skin be arrive detector from the heat emission of BTE passage before to cross over only have structure.Therefore, when by the thermal power transfer from BTE channel emission being the concentration of measured material, its correctness and degree of accuracy are very high.

The natural spectral emissions of BTE passage changes according to the existence of chemical substance and concentration.According to Planck rule, launched far-infrared thermal radiation and the heat radiation of scheduled volume can be calculated.By measuring the heat absorption outside the band of interested material, can Calculation Basis intensity.By comparing measured value and the predictive value of BTE access sites, the heat absorption in interested material band can be determined by spectroscopic apparatus.Then, according to the content of absorbed heat energy, this signal is converted to the concentration of material.

The sensor being modified to detect BTE passage provides the means for measuring interested material, utilizes the natural brain far infrared radiation of BTE channel emission, and Beer-Lambert rule in application body.Spectral radiance from the infrared energy on the surface of BTE access sites corresponds to the spectral information of chemical substance.These heat emissions under 38 DEG C of irradiations comprise 4,000-14, the wave-length coverage of 000nm.Such as, the light of absorption about 9, the 400nm band that glucose is strong.When launching far-infrared thermal radiation in BTE access sites, glucose will absorb the radiant section absorbing band corresponding to it.In heat-seal in BTE passage and thermally-stabilised environment, glucose is linear relevant to the absorption of heat energy and blood sugar concentration.

Supporting construction comprises at least one from infrared to the radiation source of visible ray and the detector for the radiation of collecting generation, radiation source in BTE passage with measured matter interaction.

The invention provides the method for measuring biological parameter, being included in BTE access sites and measuring infrared emanation, generating the output signal of telecommunication representing radiant intensity, the input value that conversion generates, and the input value of conversion is sent to processor.Processor is modified the analysis of the necessity provided signal, to determine the concentration of substances to be measured, and display result.

The present invention includes the device preferably near-ir energy led on the skin surface of BTE channel end, for analyzing reflection coefficient or backscattering spectrum and being converted into the device of the concentration of measured matter, with for light source and detector or device being placed in the supporting construction on the skin surface being adjacent to BTE access sites.

The present invention is also provided for the method determining material concentration, described method comprises electromagnetic radiation as on the skin of near infrared ray guiding BTE access sites, detect the near-ir energy from the skin of described BTE access sites, obtain the spectrum generated, generate the signal of telecommunication of this detection, process this signal, report the concentration of interested material according to described signal.The present invention also comprises the apparatus and method for light source and detector being placed on settling position, and radiation is directed to and the surface of therefrom receiver radiation has stable pressure and temperature.

The present invention also comprises the device using endocanthion pad guiding infrared energy by nose, for the device that radiation source and detector are directly placed on the contrary, with for analyzing the generation spectrum be transmitted and the device generation spectrum be transmitted being converted to the concentration of measured material.The present invention is also provided for the method measuring biological parameter, described method comprises passes through nose with endocanthion pad direct electromagnetic radiation such as near-infrared, collect from radiation near-infrared energy described nose, obtain the spectrum generated, generate the signal of telecommunication of this detection, process this signal, report the concentration of interested material according to described signal.The present invention also comprises the apparatus and method for radiation source and detector being placed on settling position, and the surface that radiation is directed through has stable pressure and temperature.

The present invention also comprises the device for collecting the natural far-infrared thermal radiation from BTE passage, for settling radiation collector to receive the device of described radiation, for the collected radiation from BTE passage being converted to the device of the concentration of measured material.The present invention is also provided for the method measuring biological parameter, described method comprises with the natural Far infra-red hot transmitting from BTE passage as the generation radiation of measuring interested material, collect the radiation spectrum generated, produce detect the signal of telecommunication, process this signal and according to this signal report substances to be measured concentration.

According to the content of the material measured at BTE passage place, activate the medication dispensing systems comprising infusion pump, such as, when needing the G/W of normalization artificial pancreas at ordinary times, automatically insulin injection.

Any material be present in blood can analyzed by calutron, can be measured in BTE passage.Such as, but whether limit, these materials can comprise exogenous chemical substances, and such as medicine and ethanol and endogenous chemical material are as glucose, oxygen, lactic acid, cholesterol, bicarbonate, hormone, glutamate, Glu, carbamide, fatty acid, triglyceride, protein, creatinine, aminoacid etc.Numerical value such as pH also can calculate by reflectance spectrometry, and pH is relevant to light absorption.

According to Figure 35, show the perspective view of preferred reflection measuring Instrument of the present invention.Figure 35 display light source 420 such as infrared LED and photo-detector 422 are placed side by side, be arranged in supporting construction 426, supporting construction is as the nose pad of the glasses of endocanthion pad or improvement, and skin 428 juxtaposition of described light source 420 and BTE passage 430, lead radiation 424 BTE passage 430.Radiation 424 is delivered on the skin 428 of BTE passage by light source 420, and owing to interacting with measured material 432, this radiation is partially absorbed, and produces the radiation 425 of decay.Then, partial radiation 424 is absorbed by material 432, and the generation radiation 425 of launching from BTE passage 430 is collected by photo-detector 422, and is converted to the haemoconcentration of material 432 by processor.Thin skin skin 428 is unique tissues between radiation 424,425 and substances to be measured 432.Optical attenuation multiple collected by detection, measures the concentration of material 432, and optical attenuation is caused by absorption by the signal of measured matter.

Because infrared LED can launch the light of known strength and wavelength, size is little, cost is low, and light can be accurately delivered on position, and infrared LED (wavelength specific LED) is the preferred light source of this embodiment.Light source 420 preferably at least launches a kind of near-infrared wavelength, but alternately, can adopt a large amount of different wave length.Light source emitted radiation 424, preferably between 750 and 3000nm, comprises the wavelength of the absorption spectrum of symbol measured matter 432.Preferred photo-detector comprises the quasiconductor with the photosurface of diameter 400 microns or photodiode that are coupled to and amplifier are formed integrated circuit.

The schematic diagram of the people 100 of supporting construction 434 and light source 436 and detector 438 is worn in Figure 36 display, and detector is modified to adopt spectral transmissions device to measure biological parameter.Light source 436 and photo-detector 438 are directly settled on the contrary, and the output of radiation source 436 is being detected before device 438 receives through the nose interface 442 containing positive test substance 440.The final transmitted radiation being guided through nose interface 442 collected by photo-detector 438.Various LED and optical fiber are disposed in supporting construction 434 as in the nose pad of endocanthion pad, glasses and framework, are preferably used as optical transport and the photo-detector 438 of light source 436.

The arm of supporting construction 434 as endocanthion pad is moveable, is adjusted on different positions, produces fixing or variable light path (opticalpath).The material of preferred measurement comprises oxygen and glucose.Brain maintains constant blood flow, and end blood flow changes according to cardiac output and surrounding.Be present in the oxidation states of the oxygen content reflection maincenter in physiology passage.Monitoring Oxygen Ventilation in physiology passage represents the overall blood dynamic conditions of human body.Can monitor the cardiac problems of many critical conditions as pyemia (diffusive infection) or the most hemoperfusion of change human body.Oxygen in BTE passage can monitor hemoperfusion constantly, the hemodynamic change of earlier detection.

Figure 37 is the cross-sectional prospective view of another preferred embodiment of the present invention, utilizes the heat radiation from BTE.Figure 37 shows the supporting construction 450 of loading thermal infrared detector 444, and have a light filter 446 and sensing element 448, described sensing element 448 is preferably thermoelectric pile, responds the thermal infrared radiation 452 that BTE passage 454 is launched naturally.Supporting construction 450 is modified, and has sensing device 448, has the geometry of skin 462 corresponding to BTE passage 454 end and the visual field of size.Supporting construction 450 provides the wall 456,458 contacted with skin 462, and described wall forms a chamber 460, and this chamber is contained through the heat radiation 453 of thin skin skin 462.

Such as, due to the carbon-oxygen-carbon bond of the pyranoid ring in glucose molecule, the spectral radiance of 38 DEG C of launching with 9,400nm band in the heat-seal and thermally-stabilised environment of BTE passage 454 is absorbed according to concentration of glucose content in a linear fashion by glucose.Final radiation 453 is that heat emission 452 deducts the radiation absorbed by material 464.Final radiation 453 enters Infrared Detectors 444, generates and corresponds to the described final spectral signature of radiation 453 and the signal of telecommunication of intensity.Then, absorb relative to the reference intensity outside material 464 band according to absorbed thermal energy, final radiation 453 is converted to the concentration of material 464.

Disclosed same principle can be used to near-infrared transmission measurement in the present invention, and quantitative for continuous wave tissue oxygenation, the evaluation of hematocrit, hemocyte and other blood constituents.Measured material can be endogenous comprise photosensitive drug as glucose or external source as ethanol and medicine.

A large amount of supporting construction by sensor placement on BTT position, can measure biological parameter.Therefore, Figure 38 is the lateral plan of the alternative embodiment of display people 100, adopts the ornaments 470 of head-mount as supporting construction, is placed on the skin at BTT position, has wire 478 and sensor 476.Microelectronics bag 472 is containing transmitting device, blood processor and power supply, and be arranged or be assemblied on headband 470, headband 470 provides the wire 478 from microelectronics bag 472, to be connected with the sensing device 476 on the skin at BTT position.

Be to be understood that, sensing device is the integration section of supporting construction, or be connected in any supporting construction, such as, adopt conventional securing member to comprise screw, safety pin, clip, joggle (tongue-grooverelationship), locking part (interlockingpiece), directly connect (directattachment), binding agent, mechanical connection etc.; Described supporting construction comprises paster, clip, glasses, wears ornaments etc.

There is provided the various devices of electric energy open to sensor-based system.BTE passage also provides a kind of new way for Nature creating electric energy.Therefore, Figure 39 is to provide the schematic diagram of the preferred version of energy to sensor-based system by BTE passage Heat of Formation electric energy.Electromotor of the present invention by the converting heat from passage for providing the electric power needed for power to system.Electrothermal module is integrated in supporting construction, provides power to sensor-based system.Electrothermal module preferably includes thermoelectric pile or thermocouple, comprises different metal wires, forms contact.When heat comes out through electrothermal module from passage, generation current.On the surface and interface of the thermocurrent produced in the temperature by BTE passage around, CHARGE DISTRIBUTION by the region of low temperature due to BTE passage, Seebeck effect provides the means generating power, when there is thermograde, and induction electromotive force (emf).

Therefore, Figure 39 shows the connection T of metal wire A470 and the metal wire B472 be kept at different temperatures ₁and T ₂, will T be connected ₁be placed on the Primary Entry Point of passage, and connect T ₂be placed on low-temperature region as the bridge of the nose (be labeled as blueness or purple in Figure 1B, referred to herein as indigo plant-purple nose).Metal wire A470 and B472 is prepared by different metal, and due to heat gradient, electric current flows to cool region from thermal region, the ratio of size of current position thermoelectrical potential.Electromotive force U is U=(Q _a-Q _b) * (T ₁-T ₂), wherein Q _aand Q _brepresent metal A and metal B ₂seebeck coefficient (thermoelectric power), and T ₁represent the temperature of the inlet point of BTE passage, T ₂represent the temperature of indigo plant-purple nose.The thermoelectric power produced can provide power to sensor-based system, be inserted into capacitor 474 in system for controlling and stored energy, and MCU476 is modified the energy delivery needed for control survey, process and signal transmission.

Should be appreciated that can adopt the thermal power transfer from BTE passage is other devices of electric power.It should also be understood that, the caruncula of eyeball surface and eyes has heat gradient and Seebeck effect, but due to accessory and conductive contact eyeball surface and/or stretch out from eyes, people is made to feel very uncomfortable and cause infection, therefore, compared with adopting the skin of BTE channel end, it does not more make us expecting.It is also understood that low-temperature end comprises any relatively cold article, comprise spectacle-frame and air.

A large amount of disclosed supporting construction in the present invention comprises glasses and is easily changed and does not provide power generation system of the present invention with not losing face, such as adopt supporting construction as glasses, with endocanthion pad, BTE place is settled in thermally coupled, and with the nose pad of conventional glasses, cold connection is placed on nose.It is also understood that and utilize the power generation system of brain fever energy to be designed to provide power to sensor-based system of the present invention, any other electric installation can be modified source of supply in the energy of brain fever energy passage.

Other embodiments comprise the BTT position of sensor placement animal by supporting construction.Can realize any useful application, comprising and improve artificial insemination the onset of ovulation by detecting, monitoring the health status of herd by monitoring brain temperature continuously, childbirth detects.

Therefore, Figure 40 is the perspective view of the preferred embodiment of display animal 101, sensor 480 is positioned on BTT position, and sensor 480 is connected with the microelectronics bag 484 in animal 101 eye pouch 486 by wire 482, and microelectronics includes transmitting device, blood processor and power supply.Signal from microelectronics bag 484 preferably transmits with radio wave 489.Signal from the emitter in bag 484 is sent to GPS necklace, makes it possible to the high temperature animal determining to have described animal present position by GPS device.Once determine that brain temperature raises by sensing device 480, high temperature signal activates GPS necklace, to locate affected animal.Alternately, when receiving abnormal signal, the long haul radio standing-meeting receiving electric wave 489 activates gps system.In this case, signal is only transmitted to distant station by the emitter in bag 484, and does not transmit to GPS necklace.

Figure 41 A is the perspective view of Portable supporting structure 490, and placement sensor 492, to contact with the skin 494 at BTT position, measures biological parameter.The supporting construction 490 being assembled into the thermometer with touch sensor 492 is held by second people 17, to be placed on skin 494 by sensor 492, measures.Figure 41 B is Portable supporting structure 496 perspective view, and have and settle non-contact sensor 498 as the wall 500 of thermoelectric pile, sensor has the visual field completely or partially matched with geometry and the size of the skin area of BTT end.The supporting construction 496 being assembled into infrared thermometer is held by second people 105, with placement sensor 498, and measures biological parameter.Although should be appreciated that according to the present invention, Infrared Detectors can be aimed at BTT position, due to the impact of environment temperature, measured by the temperature that obtains be useless clinically.Therefore, supporting construction 496 is containing wall 500, and this wall produces the restriceted envelope making to arrive sensor 498 from the radiation of passage skin heat.The wall 500 of supporting construction is modified to match with the geometry of passage, and provide the chamber 499 on the border be made up of sensor surface 492, skin area 493 is detected by described sensor 498 in the mode similar to described by Figure 37.

So far, with reference to figure 42A and 42B, Figure 42 A is presented at the schematic diagram that this is also referred to as the supporting construction 496 of box body (housing), and box body 496 is containing window 502 and radiation sensor 504, and extension 510 is fixed on box body carries out temperature survey to be adapted at BTT region.In preferred embodiments, extension 510 has wall 500, and is conical substantially, is fixed on box body 496, with as shown in figure 41b, is applicable to hand-held 105.In order to measuring tempeature, extension 510 is placed in contiguous BTT position by user 105, and make the wall 500 of extension 510 abut in BTT region, BTT region detected by radiation sensor 504.Figure 42 B is the schematic diagram that display forms the wall 500 of the extension 510 in chamber 499, and the heat radiation 506 wherein launched from the skin 508 in BTT region 518 is received by radiation sensor 504.BTT region 506 by the cycloaliphatic ring in thin skin skin and non-BTT region 512 around.BTT measured temperature obtains the output valve of the radiation sensor 504 of box body 496 from containing.The radiation received is converted to temperature levels by the electronic component 514 in box body 496, is presented on the loading display screen (housingdisplay) 516 as exemplary illustration in Figure 41 B.

Radiation sensor 504 detects the part at least BTT surface skin region 508 by infra-red radiation transparent windows 502, detects the infra-red radiation 506 from BTT skin surface 508.Radiation sensor 504 is a kind of thermoelectric pile preferably, but also can adopt other radiation sensor, and such as pyroelectricity detector or detection are from any other radiation sensor being evaluated surperficial heat flux.The material of exemplary window 502 comprises silicon and germanium.Sensor 504 is preferably installed on extending part 510, and this extension is processed to match with the size in BTT region 508 and geometry.Extension 510 is easily placed, and the skin area 508 of only BTT518 end is detected by radiation sensor 504, and wherein skin area 508 is in substantially identical with brain temperature.Detect on the position of BTT skin area 508 once be in sensor 504, press the button 522 to start to measure, brain temperature determined by processor 514 in box body 496, and shows numerical value being connected on the liquid crystal display 516 on the voice device 524 sending audio signal.Any part with the instrument of contact skin is covered with disposable lid.

Although according to the temperature of cavernous sinus and brain blood, the temperature of BTT channel end is substantially equal with brain temperature, different mathematical calculations and means can be adopted to determine the temperature in BTT region, comprise tremulous pulse heat balance, vein heat balance and environment temperature.Should be appreciated that BTT detector contains the sensor measuring environment temperature, and described measured environment temperature is used to the temperature calculating experimenter.

The temperature in BTT region is used as a kind of reference value, for being aligned in the measured value that BTT other human body parts extra-regional obtain.The electric equivalent of BTT passage is the region of high voltage low current, and wherein the voltage of representation temperature is actually equal at two ends of passage.The high perfusion of BTT end keeps high temperature on the skin of the end of described BTT end.

The present invention is also provided for detecting the method for body temperature, comprises the hygrosensor being provided in temperature detection process and being placed in contiguous BTT, and according to the step of the radiation determination temperature felt in BTT region.Should be appreciated that detector can remain on a position or around BTT region to move, determine the surface with maximum temperature.

The another kind of method detecting body temperature comprises step, other regions in BTT region and head or offside BTT region are scanned with hygrosensor, select maximum temperature, preferably by processor being assemblied in BTT detector, scanning right side and BTT region, left side, determine and select maximum temperature to select maximum temperature.

Determine that the another kind of method of the maximum temperature point in BTT region can be passed through, with radiation detector scanning BTT region, improve processor and select most high scale, and indicate this reading with acoustical signal.Hygrosensor 20 provides a kind of audible buzzer to each peakreading.

Figure 43 A-43C is the chart that the conical projections of display box body 496 end divides the preferred embodiment of the diameter of 510, and this extension contacts with the skin 508 at BTT position 518.Although should be appreciated that extension can adopt any shape, extension preferably adopts taper shape, has settled radiation sensor to detect BTT region.Cup 520 has at its end the external diameter being equal to or less than BTT region.In Figure 43 A, in order to the general areas making radiation sensor 504 detect BTT position 508, the preferred external diameter of the end 524 of cup 520 is equal to or less than 13mm.In Figure 43 B, in order to the cardinal principle Primary Entry Point making radiation sensor 504 detect BTT position 508, the preferred external diameter of the end 524 of cup is equal to or less than 8mm.In Figure 43 C, in order to make radiation sensor 504 detect Primary Entry Point, the preferred external diameter of the end 524 of cup 520 is equal to or less than 5mm.Although should be appreciated that the preferred geometry of radiation sensor and extension is round, have conical completely, radiation sensor and/or the extension of any other shape can be adopted, comprise oval, square, rectangle etc.Should be appreciated that and preferably select diameter and geometry to match with BTT region.It is also understood that the size of sensor 504 is modified to match with the size of cup 520, to detect the region of skin 508.

According to another aspect of the present invention, extension is modified to be fixed on eyelid.The part that the extension 510 of box body 496 contacts with skin 508 has the inner concave matched with eyelid profile.Alternately, the part that conical extension 510 contacts with skin 508 have with endocanthion district and canthus, inner side above the convex surface that matches of upper eyelid.

It is also understood that child uses 2/3 of the size being of a size of specification of being about grown up, what juvenile used is even the half or less of adult's specification.Therefore, the preferred size of the external diameter of the extension that child uses is: detect general areas for radiation sensor, the preferred external diameter of extension is equal to or less than 9mm for detecting the general areas of BTT, being equal to or less than 6mm for detecting the cardinal principle Primary Entry Point of BTT, being equal to or less than 4mm for detecting the Primary Entry Point of BTt.

Except the end 524 of extension 510 is preferably except circle, Figure 44 A and 44B shows the alternative geometry of end 524 and the shape of the extension 510 of non-contact sensor, described sensor detect at least BTT region adjacent in the part at the canthus 528 of eyes 526.In Figure 44 A, the profile of the end 524 of extension 510 is shown as oval.Figure 44 B shows the end 524 of ellipse, banana-shaped or semi-moon shaped extension 510, for detecting endocanthion district and region, upper eyelid.

Figure 45 A and 45B shows exemplary geometric and the shape of the supporting construction containing touch sensor, and described sensor is positioned on the skin in BTT region.Figure 45 shows the front schematic view of bar-shaped temperature sensor 530, this sensor is contained in paster 532, be positioned vertically on the BTT region 534 close to canthus, inner side 538 and nose 537, flexible cord 536 stretches out from the far-end (distalend) of sensor 530.Figure 45 B is the side view of Figure 45 A, and display has the sensor 530 of flexible cord 536, containing in the paster 532 of contiguous eyes 539.Sensor is placed on the central authorities of paster, wherein measures the region that diameter is less than 11mm.

Figure 46 A-46D exemplarily shows geometry and the shape of the nose pad of endocanthion pad or improvement, and the relation at they and canthus, inner side.Figure 46 A shows the front view of nose pad 540 improved, and sensor 542 is positioned at the central authorities of described nose pad 540, and wherein sensor 542 is positioned on the skin close to the BTT region of canthus, inner side 544 and nose 546.Figure 46 B is the side view of the nose pad 540 of eye 545 and nose 546 and improvement, and sensor 542 is positioned on BTT position.Figure 46 C shows the front view of nose pad 550 improved, and sensor 552 is positioned at the outer rim of nose pad, and nose pad is positioned on the skin area close to the BTT position of canthus, inner side 554 and nose 556.Figure 46 D is the side view of the nose pad 550 of display eye 555 and nose 556 and improvement, and sensor 552 is positioned on BTT position.

Although should be appreciated that extension be sensor not with the preferred embodiment of contact skin, also can use the infrared sensor probe being modified to the skin contacting BTT region.

Nowadays, for thermal imaging system of the present invention, Figure 47 is the schematic diagram of the preferred embodiment showing infrared imaging system of the present invention.Figure 47 shows BTTThermoScan560, comprises photographing unit 562, microprocessor 564, display 566 and power supply 568.This system also comprises holder's software (proprietarysoftware) and is customized accurately to measure and draw the software in BTT region.BTTThermoScan560 comprises the photographing unit 562 with lens 574, optical system 572 containing the mirror obtained for optimized image, light filter and lens, with the photo-detector 570 being also called radiation sensor or radiation detector at this, for quantizing within the scope of far infrared and record flux of energy.Display unit 566 shows the heat picture of the BTT detected by the lens 574 in photographing unit.The material of radiation detector known in the art is used in photo-detector 570, comprises the germanium, platinum silicide, barium strontium (BariumStrontiumTitanate) etc. of alloy indium-antimonide, hydrargyrum-cadmium-tellurides, Copper-cladding Aluminum Bar.

The incident radiation comprising BTT region is converted to exaggerated electric energy by infrared radiation detector.Detector 570 pairs of infra-red radiation responses, provide from the BTT region output signal relevant with the intensity of the heat energy that the peripheral region in BTT region receives and discrete point.

Discrete point is photographed, and each some source (pointsource) must have enough energy come stimulating radiation material for detector release electronics.Any some size (pointsize) can be adopted, preferably there is the size that diameter is 1 and 2mm.When adopting the angle of 1.3mrad, the some size that BTTThermoScan can be about 1mm from the diameter of range finder 1m distance catches instantaneous picture.Should be appreciated that any spatial resolution that can adopt best capture BTT image, but preferably between 1.0 and 1.6mrad.The photographing unit 562 of BTTThermoScan560 has the visual field being applicable to detecting BTT region.Discrete point is converted into the image of face further, comprises the BTT region at canthus, inner side and upper eyelid place.The screening function of BTTThermoScan based on the temperature in BTT region, absolute temperature, or BTT region is relative to the differential temperature of reference value.

Be shown on a monitor with intensity thermal-radiating electricity reflection, strong signal produces bright (white) point as shown in Figure 1A, and described white point representative is from the greatest irradiation energy in source.In figure ia, source is face, and maximum radiant intensity is present in BTT region.Display screen is calibrated, creates the Continuous Gray Scale gradient from dark (isothermal line 0) to bright (isothermal line 1).Each point carries out stored digital, for processing further and analyzing.

Should be appreciated that the various lens, prism, light filter, Fresnel lens etc. that this area can be adopted to know change visual angle or optimize signal acquisition, and catch the thermal energy fluxes from face and BTT region.The lens of BTTThermoScan560 are preferably with face or by the plane orthogonal in BTT region detected.

In BTTThermoScan560, radiation detector material is preferably to wavelength radiosensitive with 8-12 μm, BTTThermoScan560 has the temperature span (spanset) of 2-5 DEG C, very responsive, be modified to the temperature distinguished in the scope of 1m in 0.008-0.02 DEG C.Temperature survey is based on having the radiological unit of built-in electronic part or using reference such as black matrix to carry out differential.Although system can be uncooled, in order to maximize the efficiency of detector and obtain best signal noise ratio, solid-state device can be adopted, liquid nitrogen, the evaporation etc. of compressed argon, piezoelectricity composition.

Many radiation detectors that can detect infrared waves are just developed, comprise silicon, solid-state system and micro-bolometer (microbolometer), and all newly maybe the described system be developed is used in instrument of the present invention, detect the heat radiation from BTT, in monitor, show corresponding BTT image.

Exemplary Infrared Detectors system comprises micro-bolometer, and it is with silicon materials or containing the IC manufacturing of thermally sensitive heat proof material, and heat proof material absorbs infra-red radiation, such as vanadium oxide.Incident IR radiation from BTT region is absorbed by micro-radiation heating apparatus, and impedance and temperature produce corresponding change.Various micro-radiation heating apparatus works as pixel, and ohmically change produces the thermal-radiating signal of telecommunication corresponded to from BTT region, and this signal is displayed on the screen of computer.

The display of BTT image is the preferred embodiments of the invention, but the present invention is not also to show image mode to implement.Radiation from BTT can be obtained by aforementioned radiation sensor, can use reference value, calculate the temperature in BTT region according to the signal of telecommunication produced by radiation sensor.According to principle of the present invention, can use and detect from the heat radiation in BTT region and/or any device of temperature.

Except the temperature of the extra-regional skin surface of easy treatments B TT, as shown in the image on the screen that describes in the photo of Figure 1A and 1B, significantly lower temperature is present in the region outside BTT.When the described region outside BTT is used for sensing thermal radiation and/or measuring tempeature, the extra-regional lower and more unstable temperature of BTT causes producing inapparent temperature levels or thermal imaging clinically.

Should be appreciated that various Signal Regulation and process are for matching extra-regional for BTT temperature province and the numerical value corresponding to BTT region, those methods are also in protection scope of the present invention.In temperature taking process, the extra-regional image of BTT can also be adopted to obtain higher level of accuracy, the extra-regional image of BTT seems than BTT region more as a speckle (blur) and the double exposure of image comprising BTT region.According to principle of the present invention, by extra-regional for BTT radiation mode compared with BTT region, and can also not need the image generating BTT region, to carry out correct and accurate temperature survey, and the Quantity of heat of human body is evaluated.Any method evaluated for temperature evaluation or Quantity of heat or device, based on the temperature levels and the heat radiation that are present in BTT region, generation or not synthetic image, all fall within the scope of protection of the present invention.

Figure 48 is the schematic diagram that display is modified the thermal imaging system of the present invention 560 for airport 580, comprises infrared camera 582, processor 584 and display 586, is assembled in the supporting construction 588 on airport 580.Photographing unit 582 scans the BTT region be present in the canthus, inner side 590 of face 591, output signal is supplied to processor 584.When the people 592,593 of process sees to camera lens or taken by photographing unit 582, output signal is the signal of telecommunication relevant to the infrared radiant energy measure feature of the BTT590 in face 591.Processor 584 processes output signal, and the image in BTT region 594 is processed to form by the monitor of display 586 as computer.

Exemplarily, passenger 592 sees to photographing unit 582, and sensing is from the heat radiation in BTT region 590, and for making photographing unit 582 accurately take BTT region 590, the described passenger 582 of wearing spectacles must extract glasses.If someone is through photographing unit 582, and does not obtain the thermal imaging of BTT590, siren will be activated.Similarly, if someone thermal perturbation, the siren of indicated temperature disturbance can be activated.

Figure 49 shows the schematic diagram be modified to for the thermal imaging system of the present invention 560 in any place, this place crowd massing, such as cinema, meeting, colosseum, concert, trade show, school etc.In Figure 49, the infrared camera 596 of BTTThermoscan560 is positioned at the porch in above-mentioned place, and their certificate or admission ticket show to manager (agent) 602 by people 598, BTTThermoScan560 scans the face of people 598, catch the temperature of thermal imaging 600 and BTT passage, be displayed on long-range computer display 604.Photographing unit 596 has adjustable height and follows the trail of the tracking system of head, and thus described photographing unit 596 can settle self with the heat radiation of sensing from the people 598 of different distance and differing heights.It is also understood that BTTThermoscan560 can be used to any place, comprise optician's shop, regulate the arrangement of sensor in glasses.

There is the place of strategic importance, as government building, military base, law court, some factory etc. also will benefit from screening thermal perturbation.As shown in Figure 50, guard 606 stands in the side of Infrared Detectors photographing unit 608, and photographing unit sensing from the heat radiation in BTT region, and preferably comprises plug-in card hole (cardslot) 610 in its box body 612.Although show guard 606, BTTThermoScan of the present invention can work in undefended porch.In such an implementation, BTT thermal imaging 560 is as the key automatically opening Yishanmen 614.Therefore, office worker 616 scans its corporate identification cards (CompanyIdentificationcard) at socket 610 place, and then, instrument can point out user to see to photographing unit 608, to catch the thermal imaging in BTT region.If the temperature of BTT is in acceptable limit, the processor of ThermoScan608 can be changed with door capable of being opened 614.If BTT Temperature displaying goes out to indicate the adstante febre of PI, then office worker is indicated to go for nursing staff.This greatly contributes to security procedure in the place of process food product, and in this place, an office worker suffering from contagion disease can pollute food product by the gross.

Figure 51 is the schematic diagram of the another embodiment of the invention for monitoring the body temperature disturbance in the process of sports as athletic meeting, military training etc., and display infrared thermal detector 620 sensing is from the heat radiation 622 of athlete 624.Heat-sensitive eye 620 comprises the detector head 626 containing infrared sensor 628, digital camera 630 and one group of light, indicate the HONGGUANG 632 of athletic Quantity of heat, gold-tinted 634 and green glow 636, the temperature of athletic safety or function can be reduced with HONGGUANG 632 instruction, HONGGUANG 632 flicker instruction exceeds the temperature of level of security, gold-tinted 634 indicates boundary temperature, and green glow 636 indicates safe temperature level, and green glow 636 glimmers and indicates the suitableeest Quantity of heat or function to strengthen.Infrared sensor 628 detects heat radiation 622, if HONGGUANG 632 is activated, digital camera 626 can be taken pictures to this scene, determines the athletic quantity be in the danger of heatstroke or heat disease (heatillness).Infrared Detectors 620 also comprises the processor 638 of processing signals, and the emitter 640 of wired or wireless signal transmission.Should be appreciated that and the wider visual field can be adopted simultaneously to obtain multiple BTT signal, if the BTT radiation from second athlete 642 is by Infrared Detectors head 626 sensing.

With reference now to Figure 52 A, the BTTThermoScan of this embodiment preferably includes miniaturized solid-state Infrared Detectors 650, be assembled on the baffle plate 652 of the vehicles 654, sensing is from the heat radiation of the BTT of driver 656, ambient radiation is monitored by the processor 658 be assemblied in vehicle dashboard, determine whether driver 656 is in the danger of thermal perturbation (hyperpyrexia or hypothermia), thermal perturbation hinders intelligence and physique function, can cause contingency.Temperature except the BTT position of driver 656 can be used to weather and automatically control the control with the seat temperature of the vehicles 654.When the image at BTT position indicates high body temperature, air-conditioning is automatically activated.

Figure 52 B is the representative of the image produced by detector 650, the BTT region 660 on display display 662.Figure 48 is the representative of the example images produced by infrared imaging system of the present invention.Figure 52 B is front view, shows face and is presented at the BTT region 660 on display screen 662 and is present in BTT other regions extra-regional of face, such as forehead 664, nose 666 and buccal 668.Note that Figure 1B shows the geometric real pictures of the cardinal principle inlet point of the BTT be presented on screen, Fig. 4 A shows face and is presented at the side view in the BTT region on screen.

Figure 53 shows illustrative methods of the present invention, represents with flow chart.Should be appreciated that and various hardware, firmware and software arrangements can be adopted to carry out various signal processing and adjustment, implement the method, therefore, the step described in this article only for illustration of, and not limit the scope of the invention.Preferred embodiment comprises the heat radiation detected from source, and this source comprises the part (step 670) at least BTT region.In step 672, generate the image from radiation source, radiation source comprises the part at least BTT region.In step 674, the image that step display 672 generates.Step 676 determines temperature levels from the image that step 674 shows.Step 678 is determined, in step 676, whether the temperature of qualification matches with temperature objectives (temperaturetarget).This temperature objectives indicated temperature disturbance or instruction need the climate controlling level changing the vehicles.In view of thermal perturbation, if to occur and the target temperature of the temperature detected at BTT place and storage matches, then activate siren in step 680, point out the disturbance of experimenter occurrence temperature (such as to generate heat, hyperpyrexia and hypothermia), in step 670, continue process.If there is no mate, then step 678 advances to the operation in next step 670.

In order to strengthen the image generated by BTTThermoScan, the method also comprises the visual field of Infrared Detectors and BTT regional alignment, and removes glasses in the hot testing process in BTT region.

Figure 54 A is the perspective view of another preferred embodiment, the people 100 of the supporting construction 680 be made up of paster is worn in display, sensor 680 is positioned on the skin of channel end, be connected on the helmet 686 by wire 684, containing decoding and processing hardware 688, emitter 702 and display unit 704 on the helmet.The exemplary helmet comprises the helmet of the training for physical culture, military affairs, fire-fighting etc. that this area is known.Alternately, as shown in Figure 54 B, supporting construction comprises the eye adornment 700 with warning light 702, and the sensor 710 of eye adornment 700 is connected to by wire 704 wears ornaments as on the helmet 706.Sensor 710 has the arm 708 of a spring assembly 709, sensor 710 is settled and is squeezed on the skin in BTT region.

Refer now to Figure 55, temperature sensor 710 is worn on the nasal portion (nosepiece) 712 of mask 714, and this mask is as fire mask.Wire 716 from mask 714 is arranged in the mode of insulation, such as, be positioned in the structure of mask 714 with in the breather 718 be connected with airbag 722 by mask 714.Sensor 710 is connected to and is arranged on the transmitting set 720 of airbag 722 by wire 716.Alternately, wire 716 is disposed in the outside of breather 718.Warning light 724 in mask 714 points out fireman's high temperature or low temperature.

Figure 56 A is the figure of display BTT inlet point detection system, and this system, to the region response in body surface with maximum temperature, comprises temperature sensor 730, amplifier 732, processor 734 and pager 736.Processor 734 is modified to drive pager 736 to launch drummy speech when high temperature, and launches drummy speech when low temperature.Scan BTT region with sensor 730, make it possible to the Primary Entry Point of accurately locating BTT, the Primary Entry Point of BTT corresponds to the tone of the highest frequency generated in scanning process.Another preferred embodiment for detecting the Primary Entry Point of BTT comprises and substitutes by light warning system the buzzer or pager sounding or vibrate.Exemplarily, Figure 56 B shows pen 740, is assemblied in LED738 on panel (board) 746 and is assemblied in LED739, sensor 750 and the processor 742 on described pen 740.Pen 740 is connected on panel 746 by wire 744.Processor 742 is modified to activate lamp 738,739, in the process in scanning BTT region, finds maximum temperature.Such as, as shown in Figure 56 B, pen 740 can be assembled on the contiguous panel 746 selling the shelf (shelf) 748 of TempAlert clinical thermometer 752, makes consumer accurately can locate the Primary Entry Point of BTT.The sensor 750 of pen 740 can be such as non-contact sensor (such as electric heating heap) or touch sensor (such as critesistor).

Automatically can also carry out the detection of the Primary Entry Point of BTT.Therefore, Figure 57 display is placed on the sensor array 760 of the 4x4 on BTT.Sensor array 760, containing 16 temperature sensors, measures the temperature at BTT position.Each sensor T1-T16 in array 760 provides a temperature value output.Sensor array 760 is connected on microprocessor 754, and microprocessor is modified to identify the sensor in sensor array 760 with maximum temperature output valve, and maximum temperature corresponds to the Primary Entry Point of passage.Such as, temperature sensor T6761 is confirmed as providing maximum temperature output valve, then shows the temperature of sensor T6.The maximum temperature output valve of processor 754 continuously in an automated way in acquisition sensor array 760, shows maximum temperature continuously.

Figure 58 A is a kind of alternative embodiment, shows and is cast into the supporting construction 758 that the silicones that coincide with BTT region forms, containing wire 769 and sensor 770 in described supporting construction by a slice.Figure 58 B display has the supporting construction 758 of the sensor 770 be positioned on BTT region 775, and wire 769 extends to forehead 773 from the molded tablet of silicones structure 758.Refer now to Figure 58 C, supporting construction 758 alternately comprises the multiple structure, the sensor 770 with wire 769 and the cup-shaped silicone resin sheet 774 that are made up of Mylar surface 762, silicone resin sheet encapsulation sensor 770, makes it possible to correct and stably sensor 770 is placed in BTT region.

Of the present invention also have an object to be provide the method and apparatus of process and/or prevention thermal perturbation.As shown in Figure 2 B, except the entrance of BTT, brain is completely adiabatic in all sides.BTT is heat energy passage, wherein heat energy two-way flow, therefore, can by presenting or remove the device of heat in the external placement in the porch of BTT, from brain, remove heat or by heat in passing brain.Therefore, the heat energy bidirectional flow that Figure 59 display represents with the arrow 780 heat being carried to brain and the arrow 782 of removing heat from brain, by heat memory area 786, heat occurs and flow to brain and the distribution leaving brain 784, the described heat memory area shown in Fig. 2 B is in the central authorities of brain.The heat energy showing as cold or hot blood carrying out self-heating memory area 786 is distributed in whole cerebral tissue 784 by blood vessel 788, for the treatment of and/or prevention hyperpyrexia (heatstroke) or hypothermia.

Therefore, another object of the present invention is, provides BTT heat pad (thermalpad) that is new-type and novelty, for cold or heat being applied to BTT region to cool and heating brain.

Of the present invention also have an object to be that provide BTT heat pad that the is new-type and entrance for covering BTT region that is novelty, it may extend to other regions of face.But because brain is adiabatic in the every other side except BTT entrance, cooling is only external, fail to arrive brain, although external ice-cold sensation, at the temperature that brain is still in " frying ".Given this, preferred embodiment comprises the BTT heat pad of extension covering face, and wherein only BTT region is exposed in cold, and the remainder covering the extension BTT heat pad of face is adiabatic, prevents the gel placed in bag or ice cube from heating up.BTT heat pad container comprises the reflect radiation heat film covered in its various piece, and covers the insulator in identical or other parts, promotes directed cooling together.Therefore, when BTT is cooled, the heat only guided by BTT is absorbed.

The BTT thermal device being applied to BTT region promotes optionally brain cooling or optionally brain heating, is respectively used to process hyperpyrexia and hypothermia.Brain is the most responsive organ of the damage that causes heat, can in body temperature reduction process, apply heat by BTT or remove heat to protect in body temperature elevation process.Because the temperature of other human body parts need not be changed, cooling and heating are optionally, and when cooling brain and treating the patient suffering from apoplexy or any disease of brain, this is particular importance.The major part of cerebral tissue is water, can adopt the known formula based on BTU (British thermal unit (BTU)), and accurate Calculation cooling or the heat of heating needed for brain are removed or application.BTU is the heat content raised by 1 pound of water needed for 1 ℉, when 1 pound of water reduces by 1 ℉, and release 1BTU.

In being used for the treatment of property process brain, excessive heating or excessively cold BTT heat pad preferably include the sack with the shape being substantially funny point-like, banana-shaped or boomerang shape, described sack and whole BTT entrance are in the relation covered completely, described sack comprises outer wall and inwall, form a closed chamber and fill ice cube, gel-like material, solid material etc., for cooling or heating the BTT skin area covering BTT entrance.

A kind of exemplary brain cooling or brain heater comprise pad or the bag of hot and cold, be modified with the particular geometric fit of BTT entrance and mate, comprise the pad of preferably elasticity and sealing, gel is had in described pad, described gel is made up of the mixture of water, antifreezing agent and thickening agent, described antifreezing agent is selected from the group be made up of propylene glycol, glycerol and their mixture of combining with other compounds, and other compounds described are as the benzoate of poly sodium acrylate, soda, benzoic acid hydroxide salt (hydroxibenzoate) and their mixture.Any other comprises the cooling of the combination of ammonium nitrate and water or heater or chemical mixture and gel and is used as coolant, and heating agent is as the combination of iron powder, water, activated carbon, Vermiculitum, Sal and Purge natural mineral powder.Those compounds can purchased from many distributors (such as, the trade name ACE of Becton-Dickson).

Figure 60 A shows the diagrammatic view of preferably two BTT heat pad, and two BTT heat pad is also referred to as cold/hot bag 790 of BTT at this, is adjacent to eyes 798,802, comprises two bag systems 792,794 in right side and left side, connected by adapter 796.Figure 60 B show in further detail single bag of BTT cold/perspective view of hot pack unit 810, represent with the device being applied to left side, preferably include the pad of common funny point-like, boomerang shape or banana-shaped, this pad seals in a conventional manner at its end 812, to encapsulate a certain amount of gel-like material 800, the abundant fill-in pad 814 of this material, makes the specific portion anatomy tight connecting in the BTT region in described pad 814 and the crypts between eyes and nose.Figure 60 C is the reverse view of display extension 816, and extension matches with the depression in the BTT region of the pad 814 containing gel 800.This device is called cold/hot pad of BTT or cold/hot bag of BTT at this.Also with reference to figure 60C, display BTT is cold/perspective view of hot pack unit, it is shown as and is processed to, with medicated pillow sample structure, make it possible to cold for BTT/hot plastic type (molding) in BTT region.

In using, BTT heat pad can be placed in refrigerator or other chillers and be used as cold compress (coldcompress), or be put in hot water and be used as hot compress.BTT heat pad preferably includes pliable and tough elastoplast peplos (envelope).Material in BTT heat pad is preferably gel, and it keeps its gel-like consistency in large temperature range.There is many gels, can be cooled to freezing, and the heat absorption when heating up.There is this gel dissimilar in a large number.Some in them are frozen into solid, and some remain soft when 0 ℉.Ice bag (Coldpack) can also be used as freezing water-ethanol admixture.Alternately, the sack with inner and outer wall drawn together by BTT heat handbag, at inside plastic lining, constitutes the chamber that an opening by bag fills ice cube.In this case, this bag preferably seals with elastomeric material.

Although it is preferred material for holding gel that elastomeric material is described, be to be understood that, any material or fabric can be used, comprise the mixture etc. of vinyl (vinyl), Cotton Gossypii, artificial silk, thermoplastic, synthetic polymer, these materials.The size and shape of BTT mat structure is modified to and the particular anatomical of depression between eyes and nose matches, to match with the particular geometric of BTT entrance.

The cooling that any this area is known or heater can be used to, in BTT pad blood processor, comprise the hot water or cold water that flow through pipeline, and this pipeline is modified and is carried by heat or to be presented to BTT region.This pipeline can be assembled in any head ornaments or spectacle-frame, and drawing device is assembled in head ornaments or glasses, provides the solid stream of water by pipeline.BTT pad is connected on pipeline, pipeline have be connected to head ornaments or glasses water temperature control and cycling element on adapter.Hot water and cold water are by piping loop, and these pipelines communicate, and present or remove heat from BTT.

Elastic ribbon (Elasticband) or loop fasteners are used for BTT pad to fix in position.Any one of supporting construction is used for BTT pad to fix in position referred in this, comprises one piece of glue.Such as, BTT pad comprises clip sampling device, or BTT heat pad is fixed on the framework of glasses.The nose pad of the nose pad of glasses or the glasses of improvement comprises for transmitting to BTT or remove cooling or the heater of heat from BTT.BTT heat pad comprises the handle be assemblied on this pad, can with hand-held live or be placed on BTT region with hands, such as, at the rest period of match, held the temperature reducing brain by player, or in the winter time in contest for the brain of warm kanone.

Alternative embodiment comprises the BTT heat pad be connected on head ornaments, and supply moisture comes by evaporation to cool BTT region.In this case, cold water is produced by carrying out evaporative cooling to the upper part of scarf and forehead and wearer's head.

Any cooling or heater are used to cooling or heating BTT region, optionally cooling or heating brain, a kind of moldable device of preferred employing, the anatomy of this device and BTT entrance area adapts, and has the orientation temperature control characteristic of the skin of cooling or heating BTT porch.For heating or superheated or for any one in the device that cools, comprise known in the art and Abreu at United States Patent (USP) 6,120,460; 6,312,393 and 6,544,193 and Abreu the electricity described in other pending applications, chip, quasiconductor, polymer etc., be modified in supporting construction, for be placed in BTT entrance and for cooling or heating brain, United States Patent (USP) 6,120,460; 6,312,393 and 6,544,193 are incorporated herein by reference completely at this.

The present invention provides moldable BTT heat pad or BTT heat bag in packing device (packagingarrangement), has different pyroconductivities and heat-reflective, to extend its effective cooling/heat time heating time.The structure and material of BTT heat pad or BTT heat bag makes it possible to carry out moulding, and holds it on the BTT position of the skin between eyes and nose.Material disclosed herein can keep its elasticity plasticity under temperature in the scope of-10 DEG C-140 DEG C.

With reference to Figure 61, the front view of a kind of alternative embodiment of display BTT heat bag 820, comprise the bag 822 with gel 800, described bag has two parts, Part I 824 is positioned in the major part of BTT824, gel 800 containing maximum level, Part II 826 is positioned in the periphery of BTT, the gel containing small amount.

The cross-sectional view of BTT heat bag of Figure 62 display containing gel 800, described in wrap in its end 832,834 place and close.

Should be appreciated that can also adopt around eyes annular or comprise the shape of other parts of face/forehead, if build and the part of juxtaposition BTT heat bag on BTT region.The particular geometric in preferable shape and size and BTT region described here matches.

Figure 63 A shows the preferred embodiment of the BTT heat bag 830 of relaxed state, comprise the hard upper part 836 preferably manufactured by hard rubber or plastics, be connected on the bag 838 that manufactured by flexible plastic, described in include gel 800, deformable under external pressure effect.As shown in Figure 63 B, when compressing, BTT heat bag 830 has the convex shape 842 of central authorities' formation in the end opposite of hard upper part 836, represents, match with the BTT anatomy between the eyes 852 of people 100 and nose 854 with arrow 844.

BTT heat bag is preferably moldable, container or bag adopt deformable and within the scope of serviceability temperature pliable material structure, to match with the anatomy in BTT region.Center projections region in bag makes it possible to closely interact with BTT porch and carry out heat energy transfer, but it should also be appreciated that the given shape of the bossing of cold/hot bag of BTT itself can change a little according to ethnic group.

Figure 64 A display has the side cross-sectional view of the head 856 of the people 100 of the BTT heat bag 850 of the medicated pillow sample structure being positioned at BTT position 858.Build BTT heat bag, keep juxtaposition nearly with BTT position.Figure 64 B is the front view of the BTT hot/cold bag 850 be shown in Figure 64 A, is positioned on the BTT position 858 of contiguous left eye 862.

Figure 65 shows the perspective view of BTT heat bag 860, comprises bag 864 containing gel 800 and for BTT being wrapped the 860 hand-held rods 866 at BTT position.Figure 66 shows the front view of two bag BTT heat bag 870, has the bag 872,874 be connected to by the wire 876,878 of softness on rod 880.

Figure 67 A shows BTT heat mask 880, has eyes opening 844 and nose opening 886, is made up of the pouch (pouch) containing gel 800, comprise the bag 888,890 matched with the anatomy in BTT region.The remainder of mask 880 comprises plane domain 892.Plane domain 892 is preferably adiabatic, allows directed heat energy stream, makes gel 800 only contact the skin in BTT region.Figure 67 B is the side cross-sectional view of mask 880, and display has pouch 894 and the remaining plane domain 892 of bag 888,890.

Figure 67 C is the perspective view of the BTT heat mask 898 with pouch 895,896, can be juxtaposed to BTT region nearly when user 897 is worn.

Figure 68 A shows the perspective view that the supporting construction consisted of the eye adornment 902 worn by user 903 is applied to the BTT heat bag 900 in BTT region.Figure 68 B is the front view of the BTT hot/cold bag 930 with two bag 932,934, and bag 932,934 is for the BTT in right side and left side, and connected by arm 936, hot/cold bag, as a clip, is fixed on the BTT of user 938 by arm 936.

Comprise heat according to the cooling of the brain of principle of the present invention or brain heater with cold pad or bag, be modified to match with the particular geometric of BTT entrance and mate, be made up of the gel in preferred softness and the pad sealed and described pad, the surface of contact skin has the shape of fully projection.Therefore, Figure 69 A is the lateral plan of BTT heat bag 910 and expansion bossing 906, and expansion bossing is shelved on skin and with the anatomy of BTT and matches.Figure 69 B is the rearview of BTT hot/cold bag 910 and expansion bossing 906, and expansion bossing is shelved on skin, matches with the anatomy of BTT.Figure 69 C is the plane perspective view of BTT hot/cold bag 910 and flat 912 substantially, and flat 912 is towards outside and do not contact skin.Figure 69 D is the perspective view with the hot/cold bag 910 of gel 909 in the BTT region being applied to user 911.

The pipeline being applicable to matching with the particular geometric at BTT position and the anatomy in region with recirculated water is used to optionally cool or heat brain.

Such as add thermal agent according to chemical compound used, BTT heat bag can comprise a bag, to avoid and direct skin contact, prevents any hot injury to skin.

Should be appreciated that and can adopt supporting construction described here such as glasses and anyly wear ornaments, by the temperature sensor of combination and BTT cold/heat bag implements and settles in position.The nose pad of glasses is combined with heat flow sensor, for determining how soon the speed that heat is lowered has.Such as cross over the direction of the gradient instruction heat stream of a thin slice Mylar.It is also understood that the right side nose spacer of glasses has temperature sensor, left side has cooling/heating device, applies according to the temperature that right side is measured or removes heat.

It is also understood that many versions are obvious to those skilled in the art, in protection scope of the present invention.Such as, sensor can be placed on BTT position, then adhesive tape be placed on above described sensor, sensor be fixed on the position at BTT position.Therefore, in the present embodiment, sensor need not have tacky surfaces, does not also need permanently to be connected to the supporting construction on described sensor.

The hand-held device in a large number with noncontact or touch sensor can measure the brain temperature at BTT place, carries out single or continuous measurement, is referred to as brain temperature meter (BrainThermometers) or BrainTemp device at this.Therefore, the array 1000 of the infrared sensor 1002 of BTT entrance 1004 is detected in Figure 70 display, be assembled in box body 1006, this box body contains radiation 1010 lens 1008 collected in one way on sensor array 1000, such as sensor array 1000 only detects the skin of BTT entrance 1004, and microprocessor 1012 is modified to the maximum temperature values that selection is read by the infrared sensor 1002 in array 1000, maximum is displayed on display 1014.The exemplary infrared sensor of array 1000 comprises thermoelectric pile, thermocouple, pyroelectricity sensor.Processor 1012 processing signals, and in display 1014, show the maximum temperature values measured by the sensor 1002 in array 1000.Figure 71 A display comprises another embodiment of non-contact measurement system, except the wire 1015 being connected to external module 1017, this system comprises box body 1022, containing single infrared sensor 1018 (such as, thermoelectric pile), for the radiation 1010 in BTT region 1004 being pooled to the lens 1016 of sensor 1018, emitter 1019 and for regulating the ambient temp sensor 1020 of temperature reading according to environment temperature, and the blood processor 1012 of processing signals and displays temperature value and display device 1014, external module comprises the processor 1013 being modified further processing signals, such as process spectroscope measured value, chemical measurements and measured temperature, described module 1017 is also modified to show and be conveyed through the numerical value that processor 1013 calculates, comprise wireless transmission and transmitted by distributed computer network (DCN) (distributedcomputernetwork) such as Internet.As shown in Figure 71 B, substitute according to the one of a sample system of the present invention and Figure 71 A, comprise dilation 1024, at end 1030, there is fully protruding shape, contact with skin 1026 and match with the depression anatomy of the skin 1026 of BTT entrance 1028.The expansion lobe terminus 1024 of contact skin 1026 contributes to stretching of skin 1026, makes to have higher radiant emissivity under particular skin condition, makes system on any type-skin, measure the temperature of the skin in BTT region at optimum conditions.

Comprise for the thermal-radiating example lens system of detecting from BTT, for exemplary 25 lens of the skin 1 inch place reading at sensor distance between two tips BTT entrance, and for reading 100 sensor arraies of the radiation from inch distance of 3 between BTT skin and sensor tip.Preferably 5 degree of visuals field, most preferably the 2-3 degree visual field, and even 1 degree of visual field is used to the Primary Entry Point observing BTT.The preferred diameter of spot diameter (viewing area) of infrared sensor is between 1-20mm, most preferred diameters is between 3-15mm, make when described sensor aims at BTT entrance area, infrared sensor receives from the radiation of BTT entrance area, and BTT entrance area corresponds to the reddish yellow region in the brightened dot of Figure 1A and Figure 1B.Should be appreciated that infrared facility (thermoelectric pile) is placed on any distance, read the temperature of BTT entrance area, as long as sensor is placed in the mode of detecting BTT entrance area, with lens, radiation is pooled in temperature sensor.

Array is modified the temperature obtaining BTT region.The temperature signal obtained is less than whole face, the temperature of Bu Shi face, neither the temperature of forehead.Temperature signal from BTT, BTT be around canthus, inner side and eyebrow below the special area of particular geometric of mid portion in upper eyelid.Touch sensor (such as, critesistor), non-contact sensor (such as thermoelectric pile) and infrared thermal imaging can be passed through from the temperature signal of BTT described in this to obtain.Temperature signal described in this can be imported in processor, acts on the product of removal as described in Figure 73 or heat transfer.Described product is activated by measured temperature levels, and described temperature levels is measured at BTT place by any one of hand-held single measuring device, continuous print temperature measuring equipment and device of the present invention.In addition, temperature levels signal can activate another kind of device, and activates the function of described device.The temperature levels measured by hand-held device can by wireless or wired transmission device automatic transmission to receptor.

Figure 71 C display comprises another embodiment of non-contact measurement system, except the amplifier 1040 of processing signals and displays temperature value, blood processor 1042 and display device 1044, this system comprises containing single infrared sensor 1034 (such as, thermoelectric pile) box body 1032, load the cylindrical extension in window 1039 and chamber 1038, for the radiation 1010 in BTT region 1004 is pooled to sensor 1034, sensor 1034 is positioned at the outer about 3cm place of window 1039 of cylindrical extension 1036.The lateral dimension of cylindrical extension is less than 3mm, is preferably less than 2.5mm, is most preferably less than 2.0mm, is arbitrarily cylinder, rectangle or square.

Callable scale 1046 is assembled in box body 1032, and the tip of described scale is shelved on face, for ensureing that box body is in correct Distance geometry direction relative to BTT, to detect BTT region best.Should be appreciated that any measurement and positioner for being detected BTT by sensor the best can be used, and in protection scope of the present invention.Should be appreciated that any positioner for setting up fixed relationship between sensor and BTT is in protection scope of the present invention.

Figure 72 is the perspective view of another embodiment of the single-measurement of the skin be preferably used through with contact temperature sensor contact BTT.Therefore, Figure 72 display has sensor 1052 (such as, critesistor) a sample box body 1050, insulated most advanced and sophisticated 1054 parcels of sensor, tip has fully protruding external shape, to coincide with BTT region, also comprising the wire 1055 be connected to by sensor 1052 on processor 1056, there is with LCD display 1058, LED1060 and piezo-electric device 1062 electrical connection in processor.In using, sensor 1052 contacts the skin that BTT enters region 1004, produces the voltage corresponding to temperature, this power supply is imported in processor 1056, during interim acquisition maximum temperature when measuring, activate LED1060 and device 1062, then show this temperature in the display subsequently.Sensor 1052 and parcel most advanced and sophisticated 1054 cover with disposable cap, and this cap has the convex outer surface matched with raised tip 1054.

The temperature signal carrying out sensor 1052 is converted into audio signal, is sent by piezo-electric device 1062, described audio frequency and measured temperature levels proportional.In addition, when user scanning BTT region, the processor 1056 in box body 1050 is modified maximal audio signal (representing maximum temperature) of being kept in detention.And when reaching maximum temperature levels, the LED1060 in box body 1050 is activated, then, this numerical value is displayed on display 1058.

Should be appreciated that according to principle of the present invention, can use and anyly transmit heat in direct or indirect mode or remove the product of heat from human body.Therefore, Figure 73 display comprises other exemplary of sensing device, sensing device shows as noncontact sensing device 1070, as loaded thermoelectric pile in the handheld device, or contact sensitive device 1072, as being loaded in the critesistor in paster, the temperature in BTT region measured by sensing device, be connected on a kind of product by the wired or wireless transmitting device previously, as mattress 1078 or necklace 1080, described product 1078 and 1080 can change the temperature near self temperature or this product.Exemplary comprises mattress 1078, its signal being modified to be come according to receiving from temperature sensor 1070 and 1072 by electric installation changes its temperature, temperature sensor 1070 and 1072 measure BTT region and around the product of cervical region as the temperature of necklace 1080.Product 1078 and 1080 has bending pipeline 1074 and 1076 respectively, wherein flowing cool water or hot water, heat is presented to human body for getting on from human body except heat or by mattress 1078, or present heat to cervical region and head by necklace 1080, the water system of described mattress 1078 has valve 1082, the water system of described necklace 1080 has valve 1083, is controlled respectively by processor 1084 and 1085.The processor 1084 of mattress 1078 and the processor 1085 of necklace 1080 are modified to be opened or valve-off 1082 or 1083 according to the temperature levels of the BTT measured by sensor 1070 and 1072.The signal control valve door 1082 and 1083 of temperature sensor 1070 and 1072, when coming signal designation high fever (such as, temperature is equal to or higher than 100.5 ℉) of sensor 1070 or 1072, valve opening makes cold water fill mattress.Equally, when coming signal designation hypothermia (such as temperature is lower than 96.8 ℉) of sensor 1070 or 1072, from the unblanking valve 1082 and 1083 of described sensor 1070 and 1072, warm water is made to fill mattress 1078 and necklace 1080.Should be appreciated that any coat, adorn, clothes, the helmet, wear ornaments, eye adornment, medicated cap etc., can as a kind of product, wherein according to the temperature in BTT region, heat is removed or is transferred, and makes wearer reach thermal comfort.It should also be understood that, measure any sensor of the temperature of BTT, contact (such as, critesistor) or non-contacting (thermoelectric pile or Thermal Imaging Sensor System), be used to control product remove or heat transfer on human body or body part (physicalmatter).It is also understood that product comprises and according to the skin temperature around canthus, inner side and eyelid corresponding to BTT entrance, heat or cold liquid can be presented to the infusion path (infusionline) in the blood vessel of patient.Other exemplary products comprise footwear, have the ground of heating or cooling system, inhale electric material (electricaldraping), embedded warmer etc.

In the embodiment of touch sensor using contact skin, the head of probe covers with disposable medicated cap, and such as a slice polymer, preferably has good heat conductivity, according to principle of the present invention and disclosed content, the shape of disposable medicated cap and the mating shapes of various probe.

Except measuring, storing and transmit except biological parameter, various instrument of the present invention such as paster, eye adornment, annulus, contact lens etc. comprise acquisition and the storage device of identity and historical record, for storing identity and the historical data of user, the programmable erasable electronic module of preferred employing, wherein data can be changed, increase or delete from module.Identity and historical data separately or together with the biological data existence of chemical measurements antibody as gentle in G/W (the such as brain temperature with), are transferred to monitoring station preferably by wireless transmission.Therefore, Figure 74 show that animal uses for monitoring biology, identity and the instrument of historical data and the schematic diagram of system.Should be appreciated that disclosed system is applied to people and animal.

Figure 74 is the schematic diagram of the preferred embodiment for four lower limb biologies, show a kind of exemplary integrated system, comprise: eye thimble (eyering) discharger 1501, described eyelet (eyeloop) or eye thimble (eyering) 1501 preferably include antenna 1500, sensor 1502, micro-process, transmission and memory module 1504 and power supply 1503, described ring is placed in eyes, preferably peripheral at the eye of eye pouch (eyelidpocket) 1516; Necklace 1520, described necklace 1520 is preferably containing power supply 1506, micro-process, transmission and memory module 1508 and GPS transmission system 1510, contacted by the satellite 1514 of radio wave 1512 with orbital motion, module 1508 is contacted by the module 1504 of radio wave 1522 with ring 1501 in both-way communication, there is provided power to ring 1501 and collect the data from 1501, the described module 1508 in communication is contacted by radio wave 1511 and external radio receiving station 1509 and reception antenna 1513; The receptor 1518 of outside placement and antenna 1519, it receives the signal from the module 1504 of ring 1501; Be positioned at such as be connected to computer 1526 receptacle (feedlots) in exterior antenna 1524, described antenna 1524 contacts with the module 1504 of ring 1501 in both-way communication.

Each eye thimble 1501 has unique serial number, forever or provisionally implants in the animal in a distant place.In each transmission, send the thermograph of 24 hours, most preferably be every day 6-12 time.Unique statistical radio network structure of single-factor makes, and all herds share a kind of frequency and a set of data sink.Receptor is designed to receive the temperature remotely-sensed data from the remote sensing unit network of domestic animal eye thimble, and is transferred to collection computer, for storing, showing and monitoring.

Although various communication and dynamical system are displayed in Figure 74, be to be understood that, this system only can carry out work with a kind of instrument, such as signal is sent to receptor 1518 and antenna 1519 by ring 1501, for processing further and showing, or preferably ring 1501 transfers data to the module 1508 of necklace 1520, and module 1508 is as enhanced radio emitter, by Signal transmissions to antenna 1513 and distant station 1509, for the treatment of, monitor and show this data.

Except should be appreciated that the active system except having as the battery of power supply, can use passive system, its medium ring 1501 supplies power by external power source, the electromagnetic induction such as provided by necklace 1520 or antenna 1524.It is also understood that the heterological system of the passive system of power supply and the module 1504 that can use and comprise and being made up of battery 1503, wherein the antenna of module 1504 containing the electromagnetic energy for receiving the module 1508 from necklace 1520.In this embodiment, the active part utilization of system is provided the memory in the module 1504 of power by battery 1503, collect the data of sensor 1502 (such as, critesistor), and store data in the memory chip of module 1504.Connect when four lower limb biologies pass through the antenna that antenna 1524 is such as placed on receptacle, the passive system containing antenna in module 1504 also can be activated.When the passive system 1504 in ring 1501 is connected with the exterior antenna 1524 in receptacle, the data be stored in the memory chip of the module 1504 of ring 1501 are received by exterior antenna 1524, and being transferred to second memory chip 1523, chip 1523 is parts of module-external antenna 1524.The processor of the module 1504 in ring 1501 is modified, and shifts storing data when being connected with exterior antenna 1524.Various previously mentioned induction connection scheme is used to provide power and collect the data from eye thimble 1501 by antenna 1523 and 1509.

Data from a large amount of animal (such as, cattle) are transferred to receiving system.Preferably only animal transmits data (be only equivalent to an animal in systems in which) at special time, and to avoid the data collision of interference mutually, this interference hinders biological parameter successfully wireless transmission.Two kinds of exemplary arrangement may be utilized, Polling (polling) and report (broadcasting).Polling methods requires every animal assembling receptor, and receptor receives the serial number from the individuality needed for the data of middle position, and starts the emitter of this animal, sends data logging.Another kind method is broadcasting system, and wherein every animal reports its data logging independently.Problem is to avoid conflict, and this conflict i.e. a certain period, not only an animal was in transmission data, and this obstruction successfully transmits data.The emitter of every animal is preferably in specific time period transmission data, and receptor is modified at the signal of a certain period reception from each head animal.

Ring 1501 can also comprise layout and catch the solaode of sunlight, the Digital Transmission 16 bit ID # for the identification of animal and lifelong tracking animal.For the preferred size of ring 1501 external diameter of domestic animal between 40mm and 45mm, preferably between 35mm and 40mm, and most preferably between 30mm and 35mm or be less than 30mm.For larger animal as elephant, be used for the test-tube onset of ovulation and trimester of pregnancy for detecting, preferred external diameter between 90mm and 100mm, preferably between 75mm and 90mm, most preferably between 50mm and 75mm or be less than 50mm.The preferred maximum dimension comprising the ring of circuit board and battery of domestic animal, between 15mm and 20mm, preferably between 10mm and 15mm, is most preferably less than 10mm, for larger animal, increases 10-15mm and obtains optimum size.For the preferred heights of the ring 1501 of domestic animal between 9mm and 12mm, preferably between 6mm and 9mm, be most preferably less than 5mm, for larger animal, increase 5mm and obtain optimum size.Preferred embodiment comprises the hardware be assembled in 1/4th of ring, and this ring contains sensor, is arranged in lower eye pouch.

When reaching default temperature extremes, activate siren.Real-time Transmission temperature can use system of the present invention, detect the moment of generating heat in animal, it starts from animal heat and starts to raise.The method comprises heating and detects, and then preferably inseminates to animal between metapyretic 6-12 hour starting to detect, most preferredly detects between metapyretic 4-8 hour.

Preferably, the temperature data stored by module 1504 or 1508 lasting (such as, 24 hours) is downloaded in computer system, such as, be modified the computer 1526 determining heat mark (Thermalsignature).Heat mark represents the temperature change continuing to occur, and reflects specific biological condition.Exemplary hot quantitative character is described in Figure 75 A-75E.Figure 75 A is a kind of representative of viral infection, and wherein temperature relatively rapidly raises, and in this embodiment, exists and corresponds to poxvirus infection as the high temperature of foot and mouth disease.On the other hand, as shown in Figure 75 B, the temperature in 6-8 hour slowly raises the heat mark representing that a kind of body temperature caused due to hot climate raises.The temperature that Figure 75 C shows reflection bacteriological infection raises rapidly, and having peak value, is then sustained high temperature.Figure 75 D shows the heat mark of reflection mastitis, has two peak values, wherein has the temperature rising that initial, after the first situation (episode), then has the rising that larger.Figure 75 E shows the heat mark of indicator animal heat (arrow 1544), and wherein datum temperature incrementally raises gradually.About 8-12 hour after heating starts, temperature raises further, and the instruction onset of ovulation (arrow 1546), after the onset of ovulation, constant temperature raises unchangeably.Should be appreciated that for humans and animals, the digital library of heat mark is stored, and for according to the signal received from ring or any other sensor measuring the temperature of BTT, determines the type of existing biological condition.Heat mark needed for temperature measurement system matches with processing system, heat mark is stored in computer and is used in the memory of the related software mating and identify described heat mark.Should be appreciated that heat tag system of the present invention comprises any temperature measurement system of animal or human, in animal or human, there is thermal perturbation, low temperature or high temperature.

A large amount of antenna reception programme is used.Figure 76 A shows exemplary antenna configurations arrangement 1538, and fence (pen) comprises 8 antennas of numbering 1-8, can be used for the herd covering 1000-2000 head animal.When special time T1, animal 1530 sends data, these data by nearest antenna trapping, such as antenna 1532.Use for animal and for preserving electric power, data are stored 24 hours, when animal is at time T1 through antenna for the moment, data are downloaded.When generating heat or biological parameter changes, transmission ring transmits data continuously.In addition, this ring only transmits data once every day.Antenna configurations is also used as the location of animal.Fence and antenna configurations on the computer screen drawn, and to describe on screen, be tested and appraised the antenna of Received signal strength, animal can be located with the position of the highlighted display in computer screen.In Figure 76 A, antenna 1534 and 1532 Received signal strength, because antenna 1536 is away from animal, does not receive signal.Therefore, animal 1530 is positioned at the region covered by antenna 1532 and 1534.Figure 76 B display radio receiver orientation detector is accurately located, wherein radio receiver 1540 is carried by farmer or is positioned near the region that antenna 1532 and 1534 covers, and the animal 1530 of heating and healthy animal 1542a, 1542b, 1542c are contained in this region.Because animal 1530 is unique signals of transmission continuously, radio receiver 1540 accurately can determine the infected animal 1530 in healthy animal.The ID of animal 1530 is transmitted together with biological data, for the further qualification of animal 1530.Alternately, farmer uses the hand-held external power switch of electromagnetism, activates the circuit in eye thimble 1501 close to animal, with artificial initial data transmission to receptor, for further processing.Adopt the present invention, the animal of any loss can also be located, run animal from fence owing to not transmitting in fence, can be determined.

Although multiple antenna configurations is displayed in Figure 76 A, preferred embodiment comprises antenna 1513 or alternative antenna 1519, with the acceptor unit of weather proof mental package with radio reception module, computer interface and power supply, such as receptor 1509 or alternative receptor 1518.

When adopting erasable or programmable numbering, eye thimble 1501 is used again, and writes and record new serial identifier to described eye thimble or eye thimble 1501.

Although show the ring in eye pouch, be to be understood that, additive method and device comprise the temperature signal of the BTT from cattle, BTT is in the outside of eyes, be positioned at eyes anterior angle (canthus of animal is positioned at the foremost part of eyes), that described signal is touched or non-contacting temperature sensor and thermal imaging system are caught.

Another device of the preferred automatic activation of signal from eye thimble 1501.As explanation, automatic water sprinkler systme is modified, and is activated by the radio signal from eye thimble 1501, and when eye thimble 1501 transmits high fever signal, described automatic water sprinkler systme spraying cold water, makes animal lower the temperature.

Various disease is monitored by instrument of the present invention and is detected.As explanation, the characteristic of brain temperature raises and can detect foot and mouth disease, babesiosis, botulism, rabies, brucellosis, and any other is characterized as the disorder of temperature change, and by disorder that is chemical and physical evaluation detection, such as with the opposing eyelid of antibody test infection animal of Protein virus or the Protein virus of eyeball surface, produce appraisable labelling when antigen-antibody interaction as fluorescence or produce mechanical signal or the signal of telecommunication.Protein virus can cause mad cow disease, is also called " bovine spongiform encephalopathy ", and this Protein virus is present in eyes, and the product of sessile antibody or this Protein virus that available packages is contained in the anti-this Protein virus in eye thimble detects.For detecting mastitis (or heating animal), these animals are intended to milk, and the present invention to be milked order by generation, and the animal wherein generated heat finally is milked, and provide preventing pollution just by the method for other animals of milking.This will avoid infected animal contaminated equipment and this equipment is used by other healthy animal subsequently.

The invention provides from be born to butchering, 24 hours every days to the continuous monitoring of animal, except qualification and location infected animal, automatic analysis and detect any meeting disease that human health or animal health are constituted a threat to.Therefore, adopt the present invention, infected animal there will not be on the dining table of consumer.Therefore, the present invention includes and a kind ofly improve food safety and improve by the method for the value of meat of ingesting.Continuous disease monitoring system is referred to as DM24/7 (diseases monitoring 24/7), comprises and within 7 days 24 hours, monitor variable biology from be born to butchering, weekly, information be input in computer system, record this information.Any come the meat of animal of personal DM24/7 monitoring add a cover the seal being called " monitoring meat " (MonitoredMeat).This seal means that this animal is monitored all the life and whether there is infectious disease.The user of any purchase " monitoring meat " can sign in on Internet, and after the numbering (ID) of this meat of input, this numbering can find in bought meat packaging.Described user can access heat life (thermallife) and monitoring biology of the animal that this meat is originated, and whether this animal exists heating or disease.The method and device comprise the video string (videostream) relevant to the ID of animal, the information of described video or picture presentation farm and the farm of originating about this animal or the processed meat packing factory of animal, thus provide a whole set of about animal and the information of environment of raising this animal.Except inspecting on the internet, at private site as in family, this system also provides the information of point of sale.Therefore, no matter when user have purchased product, and the bar code of this product is such as scanned, about farm or pack the video of company of this meat or picture appears on the screen of point of sale.When buying any other product, also can adopt in this way, preferably making consumer to spend one's leisure and go shopping, with more familiar to bought product.

Preferably, this ring one end has the temperature sensor covered with adiabator (such as, having imines ester), and the surface of the other end exposes.Preferred measuring method adopts measured surface towards anatomical exterior portion of eye pouch, and heat insulating part is towards the inside part of eye pouch.

Eye thimble contains memory, for unique identification number (identificationnumber) that is permanent or that temporarily store for the identification of monitored animal.This ID code in the processor of ring is transferred to receptor as individual number, only for the identification of with tracking object, or relevant to temperature value or other biological variate-value.Memory chip in ring also containing the life cycle of animal and historical data, comprises body weight, vaccine immunity, goes out the birthday, birthplace, sex, history of disease, genetic constitution etc.

The scope of BTT area entry about 30 square centimeters, Primary Entry Point is substantially 25 square centimeters, comprises canthus, inner side and the palpebral region being adjacent to eyelid.The correlation coefficient of the temperature in BTT region and the core temperature of reflection brain Quantity of heat is 0.9.As adopting substituting of whole face, the temperature signal clearly deriving from BTT region is comprised for the method for infrared or thermal imaging sensing and touch sensor, then locate the hottest point in BTT region, be used as source signal to activate another device or to implement a kind of effect.

Should be appreciated that and can also use infrared thermal imaging photographing unit, launched originate from the point of the greatest irradiation of BTT entrance by the processor selection in photographing unit, the temperature levels with maximum heat energy corresponding to some source is shown in the display.Exemplary infrared camera comprises BTTThermoscan of the present invention.

BTTThermoscan of the present invention is modified to detect the BTT entrance around canthus, inner side, and by lens, the visual field of the sensor mated with BTT area entry is displayed in Figure 1A and 1B and Fig. 3 A-9.The example operational flow of temperature measuring BTT with thermal imaging system comprises, and the first step, detects BTT entrance with the radiation detector in photographing unit, and after the first step, processor is modified to search for the point source in the heat picture of BTT with maximum heat radiation.In step below, calculate the temperature in BTT thermal imaging with the point source of maximum radiation, described accounting temperature value is preferably shown.In then step, accounting temperature value is transferred to product by wired or wireless device, and this product can get on except heat or to human body heat transfer from human body in direct or indirect mode.In step below, the temperature of product regulates according to received signal.Transfer or comprise the air-conditioning/heating system of the vehicles from the human body exemplary products got on except heat in an indirect way.Transfer or comprise the seat of the vehicles from the human body exemplary products got on except heat in direct mode.Be modified according to measuring system of the present invention, to find the most thermal region around canthus, inner side and eyelid.Once find the hottest point around canthus, inner side and eyelid, second step comprises the hottest point in searching first step in determined region, this means the hottest point of the BTT entrance found as shown in Figure 1A and 1B.

Now according to another preferred embodiment of the present invention be presented in Figure 77 A-77C, comprise and comprise two parts according to the instrument of the paster for monitoring biology of the present invention: the permanent partial containing sensor, electronic component and power supply, and without the single use portion of any hardware, preferably by loop fasteners material (can trade name VELCRO buy obtain), linking together described durable type separably with disposable two parts.Therefore, Figure 77 A is the schematic diagram of display by the paster consisted of interconnective two parts of shackle device, VELCROPatch is called at this, described VELCROPatch1591 comprises disposable 1730 and durable 1596, described durable 1596 is loaded and electrical connection sensor 1590, power supply 1594 and emitter and processor module 1592, the VELCRO surface 1598 of durable 1596 is connected to the VELCRO of disposable 1730 on the surface separably, the outer surface lining 1732 of described disposable 1730 covers, when peeling off this lining, expose tacky surfaces, by this surface applications on skin.In using, these two parts 1730 to be connected with ring-shaped material with 1596 by hook-shaped and be fixed on appropriate location, release liner 1732, expose the binding agent covered on the outer surface of disposable 1730, this tacky surfaces is applied to skin, be fixed on skin by described VELCROPatch1591, sensor 1590 stops on the position of contiguous BTT entrance, produces the signal that brain temperature is described.Although VELCRO loop fasteners is described to the preferred connection between single use portion and permanent partial, should be appreciated that and any other connecting device can be adopted as being connected to disposable on durable by glue, safety pin etc. or any other Conventional fastening arrangements.

Figure 77 B shows two parts of VELCROPatch, comprise the single use portion 1600 only containing VELCRO material and contain sensor 1590, power supply 1594, comprise emitter, processor, piezoelectric patches, the module 1592 of buzzer and speaker, emitter and processor module 1592, and LED1602, by being electrically connected containing the VELCRO surface of the electric wire in VELCRO material with durable 1596, be connected to separably for durable 1596 on the VELCRO surface 1601 of disposable 1600, the another side of the annular surface 1601 of disposable 1600 is positioned at the outer surface of described disposable 1600 that lining 1604 covers, when release liner, expose tacky surfaces, this surface applications is in skin.Because the hardware being loaded in permanent partial 1596 is relatively costly, the described permanent partial 1596 with hardware is reusable, and single use portion 1600 only comprises VELCRO ring, can prepare on relative moderate ground, and because described part is the part with contact skin, with contact skin after or by humoral pollution time, described part 1600 is removed.Should be appreciated that permanent partial can comprise the elastoplast box body containing hardware, and the single use portion be made up of two-sided tape.In protection scope of the present invention, comprise supporting construction, as by two pasters of form of part, wherein single use portion and contact skin, and permanent partial loading hardware, circuit not with contact skin.In protection scope of the present invention; also comprise the supporting construction be made up of as VELCRO hook-shaped and ring-shaped material; comprise two parts of single use portion and permanent partial composition; wherein single use portion and contact skin; and permanent partial except VELCRO material also containing sheet, durable and not with contact skin.Unrestricted as explanation, the permanent partial of VELCRO can containing the plate (springloadrodplate) being with spring loaded mast, that as (BreatheRight of people and the Flair of animal) in Airway dilation device, and single use portion contains release liner and tacky surfaces, the contact skin of this surface and human or animal.Another kind of example comprises the permanent partial loading and have the container of liquid or chemical substance, and liquid or chemical substance are applied on skin, single use portion by tacky surfaces or mechanical fastener as elastic ribbon and contact skin.Also having another example, comprise the wrist-watch be connected on VELCRO material, as permanent partial, containing such as measuring the transducing part of glucose, and single use portion.Preferably, VELCRO part, containing as the hook of permanent partial, except VELCRO material, is loaded with sheet, the Velcro part containing hook as single use portion, this part preferably with human body part as contact skin.

When being applied on skin, VELCROPatch is as a kind of sheet, have by the hook-shaped permanent partial that is connected with ring-shaped material and single use portion, except when when biological parameter goes beyond the scope, for reminding outside the annunciator such as LED of user, at permanent partial outwardly less than other hardware.Therefore, Figure 77 C shows the perspective view of the VELCROPatch of Figure 77 B, described VELCROPatch1724 is applied on the skin around eyes 1726, the outer surface of permanent partial 1722 contains LED1720, and LED1720 is activated by the processor be loaded in the permanent partial 1722 of VELCROPatch1724 and driver module (not shown).

VELCROPatch of the present invention can also comprise the syndeton for being connected to by lens on described VELCROPatch, is called VELCROEyewear at this.Therefore, the schematic diagram of the VELCROEeyewear1710 that Figure 78 is made up of permanent partial 1712, except be modified hold lens 1702 groove except, permanent partial is loaded with sensor 1700, power supply 1706 and transmitting-processing module 1704, and lens 1702 can slip into groove 1708 and be fixed in the trench.Groove structure of the present invention makes it possible to use and replaces the lens of any type on demand.But, should be appreciated that and lens 1702 permanently can be connected on VELCRO permanent partial 1712.It is also understood that the mode that can match with face's anatomy prepares VELCRO material, the previously described various fixtures for connecting lens can be used.VELCROEyewear also has the support (temple) being connected to its side, for being fixed in the face of user further.It is also understood that and can use any sensor, comprise the temperature of the pulse for detecting blood vessel, pressure, the sensor of piezoelectricity, glucose sensor, etc.

Figure 79 A is the perspective view of another exemplary of display support structure 1740, supporting construction comprises a bowl spline structure, have the outer surface 1742 of abundant projection, to match with the anatomy of BTT entrance, described supporting construction 1740 loads sensor 1744 and electrical connection.Another embodiment of Figure 79 B display support structure 1748, have the outer surface 1750 of abundant projection, to match with the anatomy of BTT, structure 1748 is also fully extended, to match with the geometry of BTT entrance, and load sensor 1752 and electrical connection 1754.

Figure 80 is the cross-sectional view of the bowl be presented in Figure 79 A, comprise bowl-shape holder 1756, there is the outer surface 1757 of protrusion and sensor 1758, the skin 1759 of described sensor and BTT and the tail vein 1755 closely juxtaposition of BTT outstanding from the surface of bowl-shape holder 1756.

Figure 81 A is the top perspective of another preferred embodiment of supporting construction, this supporting construction is made up of the paster 1760 of boomerang shape or banana-shaped, paster comprises the thin adiabatic polyurethane layer 1766 of loading supporting construction 1762, sensor 1764 is loaded with in supporting construction, sensor 1762 has the height being different from layer 1764, this makes sensor 1764 give prominence to, and is on the higher position of the layer 1766 that compares.Pressure-sensitive acryloid cement is contained, for described paster is fixed to skin in the surface of layer 1766.Figure 81 B is the side perspective view of the boomerang shape paster 1760 of Figure 81 A, shows the differing heights be loaded with between the structure 1762 of sensor 1764 and electric wire 1765 and viscosity polyurethane layer 1766.Preferred heights difference between structure 1766 and 1762 is 5mm, preferably in the middle of 3mm and 4mm, most preferably between 1mm and 3mm.Figure 81 C is the schematic diagram of the paster 1760 on sensor region 1768 with release liner, and release liner 1773 is made up of two sheets, upper slice 1769 and bottom sheet 1771.Figure 81 C shows slices 1769 and is stripped, and exposes tacky surfaces 1770.Release liner 1773 comprises single part or has single or multiple breach and forms many parts lining.The suitable release liner used together with viscous layer is known in the art.According to the present embodiment, when paster 1760 is applied to BTT region, first can removes sensor lining sheet 1768, then paster 1760 is placed, make sensor region and BTT entrance juxtaposition.Once determine the final position of correct paster 1760, remove bottom sheet lining 1771, paster 1760 is applied to nasal area, then removes a lining 1769, be applied on the skin above eyelid.Figure 81 D is the perspective view that display is used to the paster 1760 on the skin of user 1770, paster 1760 has external label, indication sensor position 1768 and the line 1772 aimed at canthus, inner side.Should be appreciated that the present invention comprises sensor arrangement in supporting construction, wherein said sensor is positioned on the height different from the larger base support structure comprising paster.

Figure 82 is the top view of eye adornment, the exemplary electrical arrangement of display support structure, this supporting construction is made up of the framework of the nose pad improved and eye adornment, the framework on the left side rims of the lens 1776 of described eye adornment 1880 comprises electromagnetic switch 1774 and in left legportion 1882, there is magnetism stick 1778, this system is started for the electricity when electrical contact, electric wire 1888 in emitter on the bridge of the nose 1886 and power module 1884 scioptics edge 1776 is electrically connected on switch 1774, and the antenna 1890 in left side lenticular edge 1892 is connected in module 1884.When kick portion uses eye adornment, between switch 1774 and magnetism stick 1778, define electrical connection, automatically activation system.Should be appreciated that various spring mechanism can be integrated in shaft (shaft), sensor fixed, with by residing sensor better with BTT region juxtaposition.

The invention provides the method for optimizing fluid intake, to arrive desirable hydration (euhydration) and to avoid dehydration and excessive hydration.The invention provides the core temperature monitoring of continuous print Noninvasive, when temperature reaches specific preset level, such as reflect that the temperature that the heat stored in human body increases raises, then reduce body temperature by picked-up liquid: brain temperature reflection hydration status, and dehydration can cause core (brain) temperature to raise.According to method of the present invention, comprise the operation method for the people in people's (as illustrated by the high mortality in heat wave) of situation of dewatering, the sitting be exposed in sweltering heat, sports.The present invention shows, when body temperature reaches 100.4 ℉, body temperature will be reduced to 98.6 ℉ by picked-up per hour 4 ounces of water, and under body temperature will being remained on the temperature lower than 99.5 ℉, thus prevent the danger of heat apoplexy.Participate in sports activites as when to pedal athlete, the present invention shows, picked-up contains the liquid of carbohydrate and mineral (such as, the commodity of Coca-ColaCompany are called PowerAde), when the temperature of BTT reaches 99.3 ℉, picked-up 6-8 ounce can keep best function, and often within 1-2 hour, carrying out picked-up can keep function.According to principle of the present invention, the various computings being in the situation in overheated danger for athlete can be set up.The athlete that being alerted in contest process needs to absorb liquid uses the carrying liquid of specific dimensions or the container of water.

The method and algorithm that temperature (hypothermia) are associated with the nutriture (malnutrition) in old people and anorexia nervosa person can be set up, temperature levels instruction malnutrition, also which kind of food of instruction picked-up maintains enough temperature.It is also understood that and can also develop food according to body temperature, newly with food that is freezing or processing to reach best nutritive value-fresh.It is also understood that the temperature change of instruction ovulation can be used as producing the method for the food improving fertility, by determining which kind of food product improves ovulation.

The present invention is also provided for the method and apparatus evaluating diet, such as caloric restriction, wherein temperature instruction metabolism, thus lower datum temperature instruction metabolism decline and metabolic waste generate, and comprise the picked-up of monitoring carbohydrate and metabolism.The present invention is also provided for monitoring the hypoglycemic method in diabetics, and wherein temperature reduces is hypoglycemic sign.The present invention is also provided for detecting lung qi infraction and raising the method for relevant cardiac event to specific temperature.Any symptom relevant to temperature change with method prediction of the present invention and can detect, from the abnormal hyperpyrexia to head injury of the gestation relevant to temperature decline.

The invention provides other advantages various.Other exemplary advantage comprise: 1. monitor multiple sclerosis, because brain temperature rising can cause severity of symptoms, when method of the present invention determines that this temperature raises, can measure accordingly, such as in due course between drink cold liquid or cool brain as described previously, 2. the significant difference instruction pathologic central nervous system symptom between the BTT of the left and right sides, 3. detect brain temperature and raise the diagnosis strengthened meningitis or encephalitis, thus avoid excessively in not infected crowd carrying out lumbar puncture (lumbartap), body temperature can not be regulated and controled in the mode identical with adult with 4. immature babies, easily overheat.Sudden infant death syndrome (SIDS) is the most common in overheated baby.By monitoring the body temperature of baby, the present invention can remind father and mother when infant temperature raises.

The receptor received from the signal of sensor-based system of the present invention can be outside or implantable.When being implanted in human body, receptor can provide power to battery recharge to receptor by outside magnetic induction or outside.Receptor receives the signal from temperature sensor, glucose sensor etc., and forwards this signal for further display.

Any emitter of the present invention can combine with bluetooth, the transmission of GRPS data etc.Then, the signal from emitter is caught by any Bluetooth-enabled device, as mobile phone, electronic organizers (electronicorganizer), computer etc.The software of mobile phone is modified to receive the coded signal from emitter.Operation method in receptor will be described this signal and show this numerical value.Mobile phone has the auto dialing of calling doctor, such as, when instruction adstante febre.Should be appreciated that and be transferred to the computer be connected on Internet, for transmitting in distributed computer network (DCN) from the signal of mobile phone or the signal of the emitter that directly carrys out self supporting structure.

Prior art employing face temperature monitors body temperature as detection means.As shown in Figure 1A and 1B, the temperature of facial skin in the different areas between be changed significantly, do not represent core temperature.In addition, the temperature of skin of face is not present heat energy in a stable manner.Adopt face temperature to activate any device or the method for another device or monitoring body temperature, one can not be provided accurately or accurately to respond.In addition, face temperature does not reflect the Quantity of heat of human body, and dependency between core temperature and brain temperature is poor.Direct and undisturbedly with the specialized region that unique body surface of human body internal communication is the particular geometric being positioned at BTT entrance.Any temperature sensing device being placed on or being adjacent to BTT entrance can with accurate and correct mode measurement core temperature.Should be appreciated that and can adopt any sensor comprising colorimetric adhesive label, such as liquid crystal two-color thermometer, be placed on the skin in BTT region, also within the scope of the invention.

Refer now to previously described automatic Climate Control System, exemplary will describe in further detail.Although this preferred embodiment will be described in the cabin for transport vehicle (such as dolly), but be to be understood that, the method, device and system can be applied in the scope of any restriction, such as, in family, working space, hotel etc., wherein regulate according to the temperature of BTT the temperature limited in environment, make the experimenter limited in environment feel hot comfort.

The measured temperature of BTT represents the hot comfort of human body.Show research of the present invention, when human body temperature raises or reduce, be reflected as in the brain temperature of BTT and change, the hot comfort of human body reduces.The hot comfort of the mankind is reflected as the skin temperature of BTT, and the skin temperature of higher BTT produces hot human body sensation, and the skin temperature of lower BTT produces the human body sensation of low temperature.In order to the comfort level making the owner in cabin obtain heat, system of the present invention controls the hot comfort in cabin according to the temperature signal that BTT produces.The present invention preferably adopts the specific specialized region of face, instead of whole face controls the temperature in cabin and the hot comfort in cabin.System of the present invention is monitoring temperature on the region being less than whole face preferably, carries out Optimal Control to the heating and cooling in cabin, makes the owner in cabin obtain hot comfort.

Because hot comfort is reflected in brain temperature, regulate cabin weather according to BTT temperature, the environment of thermal comfort is provided to the owner in cabin.Other parts of setting BTT temperature control HVAC (heater-air-conditioning) and the previously described vehicles, such as seat, carpet etc., they are conditioned and the hotness of owner are maintained in comfortable state.Especially, the article of contact or contiguous human body are used to automatically remove heat according to the signal of BTT or be applied on the human body of owner by heat.In order to improve hot comfort further, this system comprises the temperature sensor in cabin, for detecting cabin temperature.Therefore, Figure 83 shows exemplary automatic Climate Control System, comprise for the temperature sensing device 1894 (such as eye adornment) of the BTT of contact measurement and the temperature sensing device 1895 (such as Infrared Detectors) for the BTT of non-cpntact measurement, for monitoring the temperature of BTT, control device 1896 is modified the article 1898 in automatic adjusting cabin room 1900, remove according to the signal that BTT sensing device 1894 produces or present heat, the temperature in cabin 1900 is detected with cabin temperature sensor 1902, when signal designation high temperature from BTT sensor 1894, article 1898 in cabin are modified and remove heat, when BTT sensor 1894 indicates low temperature, then present temperature.Although for illustration of object, the seat of the vehicles is used as the article removing/present heat, should be appreciated that and other article can also be used as HVAC, carpet, steering wheel and other previously mentioned article.As long as the vehicles are started, cabin sensor 1902 detects cabin temperature, and regulates article 1898 according to the temperature signal from cabin sensor 1902, removes or presents heat.Then or simultaneously pass through sensor 1902 survey room room temperature, the output valve of BTT sensor 1894 be input in control device 1896, control device is removed according to the signal activation article 1898 from BTT sensor 1894 or presents heat.If BTT sensor 1894 indicates high temperature (>98.8 ℉), so article 1898 can remove heat, if BTT sensor 1894 detects low temperature (<97.5 ℉), then article 1898 will present heat, to obtain the hot comfort in cabin.Exemplary for cooling comprises the control device 1896 be connected on air-conditioner control system, for controlling the content of the cold air generating in proportion according to the temperature levels of BTT sensor 1894 output and brush.For exemplary heating, control device 1896 is connected in control system 1906, according to the output level of BTT sensor 1894, regulates heat to present gradually by the vehicle seat 1898 of electricity.When the temperature of BTT is in the scope of 97.5 ℉ to 98.8 ℉, control device 1896 is modified to remain neutral, and does not regulate article 1898.Hot comfort due to everyone is different, and this system is modified the individual need according to owner, according to specific temperature threshold, removes or presents heat, and needing not to be according to the default setting of 97.5 ℉ to 98.8 ℉.Should be appreciated that the combination of the skin sensor of other parts being placed on human body can use together with BTT sensor 1894.It should also be understood that, the change speed of skin temperature is taken into account, be imported in microprocessor, processor is modified and regulates article according to the great variety of the skin temperature at BTT position, such as human body reduces suddenly more than 0.6 DEG C, the corresponding minimizing of the cold air content generated or even close air conditioning system.It is also understood that BTT sensing device comprises contact device (such as paster of the present invention and eye adornment), non-contact device (such as infrared facility of the present invention, thermal imaging (such as BTTThermoscan of the present invention) etc.

Another is also had to comprise the supporting construction containing the sensor measuring biological parameter according to embodiment of the present invention, be connected to air flue nose silver (strip) being expanded people, such as BreatheRight (can buy and obtain, commodity are called BreatheRight), for expanding the air flue (can buy and obtain, commodity are called Flair) of animal.Exemplary Airway dilation device nose silver is described in United States Patent (USP) 5,533,503 and 5,913, in 873.Airway dilation device is attached in the paster for monitoring biology by the present invention.The present invention can be the integration section of Airway dilation device.Airway dilation device is expansion of the present invention.The paster and the air flue dilator that connect measurement biological parameter are convenient and useful, and this is because they are useful in identical activity.Sleeping, in sports process or when suffer from cold or respiratory tract infection time, nasal meatus dilator is useful, monitors body temperature and to change and monitoring is generated heat in respiratory tract infection process, use paster of the present invention in sleep procedure, in sports.Nasal meatus dilator and paster of the present invention use binding agent on its backing, and to be fixed on skin, be all fixed on the skin of bridge of the nose bone, BTT paster is above bridge of the nose bone, and Airway dilation device is preferably in the below of bridge of the nose bone.The nasal meatus dilator extension of paster of the present invention is called BioMonitorDilator (BMD) at this.Therefore, Figure 84 is the front view of the preferred embodiment of the people 100 wearing BMD1908, the paster 109 comprised by being connected to by linking arm 1907 on Airway dilation device nose silver 1909 is formed, described BMD is placed on nose 1911, paster 109 containing indicant line 111 and containing be positioned in nose 1911 upper part channel end skin on active sensor 102 and be positioned in user 100 nose 1911 lower part skin on Airway dilation device nose silver 1909.The embodiment of the BMD1908 shown in Figure 84 provides discharger 104, blood processor 106, and a/d converter 107 and sensing device 102, be connected on power supply 108 by flexible circuit 110, is loaded in paster 109.Although display is linking arm, should be appreciated that BMD can be prepared to a sheet, wherein upper part loads sensor and circuit, and be positioned at nose comprise compared with lower part the spring silver worked as nose Airway dilation device.The present invention monitors the method for biological parameter simultaneously when being disclosed in expansion nose air flue.

Another embodiment comprises a large amount of test kits shown in Figure 85 A-85D.Therefore, Figure 85 A is the perspective view of test kit 1910, containing adhesive tape 1912 and the activity sensor 1914 be connected on 1916.Activity sensor 1914 is not connected in supporting construction, and in using, described sensor preferably contacts with adhesive tape 1912 and places, and is fixed on skin by sensor 1914 with the tacky surfaces by adhesive tape 1912.The another embodiment shown in Figure 85 B comprises test kit 1918, containing supporting construction 1920 as paster, clip, eye adornment (such as glasses, sunglasses, protective eye lens and protective glasses) etc., with receptor 1922, such as wrist-watch, in addition mobile phone, electronic organizers etc. can be used as receptor, form a part for test kit.As discussed previously, test kit 1918 is also loaded with Magnet 1923 as switch in its structure.Should be appreciated that test kit 1918 only can comprise paster, Magnet 1923 is adjacent to described paster 1922.Wrist-watch 1922 preferably has the surface of inclination, so that in sports as observed better in process to pedal, the visual field of wrist-watch 1926 is by a certain angle towards the face of person to pedal, as long as so that towards seeing, and not needing rotary head, user just can see the temperature levels be presented on wrist-watch 1926.Another embodiment be presented in Figure 85 C comprises test kit 1932, and the BMD paster 1928 containing specialization and example are the receptor 1930 of wrist-watch.

Another embodiment comprises footwear, have for detect cold temperature sensor and for by Signal transmissions to the transmitting set of receptor (such as wrist-watch).From the signal combination of footwear from the signal of the TempAlert of BTT, provide the combination of the prophylactic device of opposing cold injury and hypothermia.

Should be appreciated that supporting construction such as paster may load steam, when the outer surface of paster is scratched, the steam containing Mentholum is released to make smooth surface, and alleviates nasal blockage, and when monitoring adstante febre with paster, this is very easily.

It is also understood that and can steel or copper are placed in above sensor, to improve heat conductivity, and adopt any other conventional means to increase transfer of heat on sensor.

Should be appreciated that any electrochemical sensor, thermoelectric pickup, acoustic sensor, piezoelectric transducer, the available support structures such as optical pickocff are fixed, and measure biological parameter according to principle of the present invention.Should be appreciated that adopt electric current, electromotive force, conductance, impedance can be used in instrument of the present invention, for measuring biological parameter with the sensor of the system of fluorescence etc.It is also understood that other forms that can adopt bio-sensing, the change of such as ionic conductivity, enthalpy and quality and the biological work mutually of immunity etc.It is also understood that and can be used in the present invention according to the aitiogenic new material of temperature and heat transfer oil crystalline polymer, be positioned on BTT position.

Aforesaid description should be interpreted as only example and principle of the present invention is described.Because a large amount of improvement and change are obvious for a person skilled in the art, shown in undesirably limiting the present invention to and in described accurate structure and operation, therefore, in all adoptable suitable improvement and the equal protection scope of the present invention of equivalent.

Claims (7)

1. a detector, comprise: on the skin being positioned over brain tunnel and shape be suitable for receiving from the radiation energy probe of the infrared energy of the skin at brain tunnel place, described brain tunnel is positioned on the skin in endocanthion district at adjacent medial side canthus, endocanthion district to be positioned at above inner canthal ligament and to be positioned at the inner side 1/3 in upper eyelid, the end diameter that wherein said described brain temperature passage is positioned at BTT region on the skin measured from the canthus, inner side of inner canthal ligament is about 11mm, and upwards extend about 6mm, then give prominence to angle sample and extend 22mm again on region, upper eyelid

Described detector is disposed on paster as sensor, the full-size of described paster is equal to or less than 12mm, preferably be equal to or less than 8mm, most preferably be equal to or less than 5mm, and the outer peripheral minimum range from the outward flange of the described detector as sensor to described paster is equal to or less than 11mm, preferably be equal to or less than 6mm, and be most preferably equal to or less than 2.5mm.

2. a detector, comprise: on the skin being positioned over brain tunnel and shape be suitable for receiving from the radiation energy probe of the infrared energy of the skin at brain tunnel place, described brain tunnel is positioned on the skin in endocanthion district at adjacent medial side canthus, endocanthion district to be positioned at above inner canthal ligament and to be positioned at the inner side 1/3 in upper eyelid, the end diameter that wherein said described brain temperature passage is positioned at BTT region on the skin measured from the canthus, inner side of inner canthal ligament is about 11mm, and upwards extend about 6mm, then give prominence to angle sample and extend 22mm again on region, upper eyelid

Described detector is disposed on glasses as sensor, described glasses comprise spectacle frame, endocanthion pad, linking arm and conventional nose pad further, wherein said endocanthion pad comprises the described detector as sensor, it is upper and adjacent with conventional nose pad that endocanthion pad is connected to spectacle frame by described linking arm, and the described detector as sensor is positioned in the top in the endocanthion district at adjacent medial side canthus.

3. a detector, comprise: on the skin being positioned over brain tunnel and shape be suitable for receiving from the radiation energy probe of the infrared energy of the skin at brain tunnel place, described brain tunnel is positioned on the skin in endocanthion district at adjacent medial side canthus, endocanthion district to be positioned at above inner canthal ligament and to be positioned at the inner side 1/3 in upper eyelid, the end diameter that wherein said described brain temperature passage is positioned at BTT region on the skin measured from the canthus, inner side of inner canthal ligament is about 11mm, and upwards extend about 6mm, then give prominence to angle sample and extend 22mm again on region, upper eyelid

Described detector is disposed on glasses as sensor, described glasses comprise the nose pad of improvement, the power supply that there is the described detector as sensor and processor, perspiration sensor and fixed by leg of spectacles, with the emitter fixed by leg of spectacles, all these are electrically connected, and the super-huge nose pad that the nose pad of described improvement has sample extension, angle by top forms, and is arranged on channel end by described detector.

4. a detector, comprise: on the skin being positioned over brain tunnel and shape be suitable for receiving from the radiation energy probe of the infrared energy of the skin at brain tunnel place, described brain tunnel is positioned on the skin in endocanthion district at adjacent medial side canthus, endocanthion district to be positioned at above inner canthal ligament and to be positioned at the inner side 1/3 in upper eyelid, the end diameter that wherein said described brain temperature passage is positioned at BTT region on the skin measured from the canthus, inner side of inner canthal ligament is about 11mm, and upwards extend about 6mm, then give prominence to angle sample and extend 22mm again on region, upper eyelid

Described detector be disposed in as sensor there is fixing endocanthion pad protective eye lens on, described protective eye lens also constant transmissions device, power supply, local annunciator as LED and the antenna for remote reporting, described antenna is preferably integrated into a part for the rims of the lens of protective eye lens, and described protective eye lens is suitable for described detector to be placed in the access sites of skin.

5. a detector, comprise: on the skin being positioned over brain tunnel and shape be suitable for receiving from the radiation energy probe of the infrared energy of the skin at brain tunnel place, described brain tunnel is positioned on the skin in endocanthion district at adjacent medial side canthus, endocanthion district to be positioned at above inner canthal ligament and to be positioned at the inner side 1/3 in upper eyelid, the end diameter that wherein said described brain temperature passage is positioned at BTT region on the skin measured from the canthus, inner side of inner canthal ligament is about 11mm, and upwards extend about 6mm, then give prominence to angle sample and extend 22mm again on region, upper eyelid

Described detector and supporting construction and combination of light sources, described detector is modified to adopt spectral transmissions device to measure biological parameter, described light source and photo-detector are directly settled on the contrary, the output of radiation source is being detected before device receives through the nose interface containing positive test substance, the final transmitted radiation being guided through nose interface collected by described photo-detector, various LED and optical fiber are disposed in supporting construction as in the nose pad of endocanthion pad, glasses and framework, are preferably used as optical transport and the photo-detector of light source.

6. a detector, comprise: on the skin being positioned over brain tunnel and shape be suitable for receiving from the radiation energy probe of the infrared energy of the skin at brain tunnel place, described brain tunnel is positioned on the skin in endocanthion district at adjacent medial side canthus, endocanthion district to be positioned at above inner canthal ligament and to be positioned at the inner side 1/3 in upper eyelid, the end diameter that wherein said described brain temperature passage is positioned at BTT region on the skin measured from the canthus, inner side of inner canthal ligament is about 11mm, and upwards extend about 6mm, then give prominence to angle sample and extend 22mm again on region, upper eyelid

Described detector is positioned on BTT position to measure biological parameter via supporting construction as sensor, headband is as described supporting construction, be placed on the skin at BTT position, there is wire and sensor, microelectronics includes transmitting device, blood processor and power supply, be arranged or be assemblied on described headband, described headband provides the wire from microelectronics bag, to be connected with the described detector as sensor on the skin at BTT position.

7. a detector, comprise: on the skin being positioned over brain tunnel and shape be suitable for receiving from the radiation energy probe of the infrared energy of the skin at brain tunnel place, described brain tunnel is positioned on the skin in endocanthion district at adjacent medial side canthus, endocanthion district to be positioned at above inner canthal ligament and to be positioned at the inner side 1/3 in upper eyelid, the end diameter that wherein said described brain temperature passage is positioned at BTT region on the skin measured from the canthus, inner side of inner canthal ligament is about 11mm, and upwards extend about 6mm, then give prominence to angle sample and extend 22mm again on region, upper eyelid

Described detector is positioned on BTT position as sensor, and is connected with the microelectronics bag in animal eye pouch via wire, and described microelectronics includes transmitting device, blood processor and power supply.