CN105214157A - Apparatus for purifying blood and system - Google Patents
Apparatus for purifying blood and system Download PDFInfo
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- CN105214157A CN105214157A CN201510742232.9A CN201510742232A CN105214157A CN 105214157 A CN105214157 A CN 105214157A CN 201510742232 A CN201510742232 A CN 201510742232A CN 105214157 A CN105214157 A CN 105214157A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
- A61M1/1627—Dialyser of the inside perfusion type, i.e. blood flow inside hollow membrane fibres or tubes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3687—Chemical treatment
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Abstract
The invention provides a kind of apparatus for purifying blood simultaneously possessing perfusion and adsorption function and the blood purification system built with it.Wherein, apparatus for purifying blood comprises unit with dialysis, linkage unit and perfusion unit.Unit with dialysis comprises dialysis cartridge, and the import of unit with dialysis forms the blood inlet of apparatus for purifying blood.Linkage unit comprises front port, rear port and the open-close on-off for controlling connection therebetween, the port of export port fixed seal connection of front port and unit with dialysis.Perfusion unit comprises adsorption column, along the axis of this adsorption column, the middle part of adsorption column filter chamber sidewall is provided with side through hole, and the port of this side through hole away from filter chamber and the rear port fixed seal connection of linkage unit, be provided with the inlet screen with intercommunicating pore between the rear port of linkage unit and filter chamber; The blood outlet of the export mixes apparatus for purifying blood on two axial ends of adsorption column.This apparatus for purifying blood can improve safety and the speed of blood purification treatment simultaneously.
Description
Technical field
The present invention relates to medical instruments field, specifically, the blood purification system relating to a kind of apparatus for purifying blood and build with this apparatus for purifying blood.
Background technology
Combined artificial kidney is the apparatus for purifying blood that hemoperfusion (HP) is combined in a kind of hemodialysis (HD), it makes full use of the advantage of hemoperfusion and hemodialysis, there is the advantages such as good biocompatibility, untoward reaction is few, the blood purification time is short, and the various toxin in the patient such as uremia can be removed comprehensively.
The blood purification system of existing combined artificial kidney composition is made up of blood circuit venous line four part flowing out the blood circuit arterial line of human body, perfusion device, dialyser and flow into human body.As shown in Figure 1, blood circuit arterial line is provided with the arterial end 01, blood pump 02, tremulous pulse kettle 03 and the tremulous pulse kettle side pipe 04 be located on tremulous pulse kettle 03 that are connected by pipeline successively in direction of flow of blood; Blood circuit venous line is provided with the venous chambers 012 and vein end 014 that are connected by pipeline successively in direction of flow of blood, and is located at the venous chambers side pipe 013 on venous chambers 012; The blood mouth of perfusion device 07 front end is connected with the rear port of blood circuit arterial line by connectivity port 06, and is provided with a safety clamp 05 between the rear port of connectivity port 06 and blood circuit arterial line; The blood mouth of dialyser 011 front end is connected with the blood mouth of perfusion device 07 rear end by connectivity port 08 and connectivity port 010, is provided with a safety clamp 09 between connectivity port 08 and connectivity port 010; The blood mouth of dialyser 011 rear end is connected with the front port of blood circuit venous line.The clinical treatment mode of this blood purification system is that first hemodialysis (HD) is combined hemoperfusion (HP) and treated 2 hours, carry out separately hemodialysis 2 hours again, by the work of blood pump 02 arterial blood extracted out through perfusion device 07 and dialyser 011 or only after the purification of dialyser 011 again through blood circuit venous line, by through detoxification, anhydrate, electrolyte exchange after in the defeated the Huis' body of blood that purified, temporarily play the effect of alternative human kidney function.
Perfusion device carries out absorption by the adsorbent be filled in its adsorption column filter chamber to blood and reaches purification object, blood perfusion device is quickly move through to shorten the blood purification treatment time in order to enable blood, along with the increase of blood flow in perfusion device, perfusion device internal blood applied pressure is also increased thereupon, be limited to the maximum pressure that perfusion device inside can bear, the maximum blood flow causing existing conventional blood perfusion device to allow is generally 200 ml/min.But, with blood perfusion device with the use of the hemodialyzer maximum blood flow that can allow can reach 300 ml/min to 400 ml/min, in therapeutic alliance process, the blood flow of whole combined artificial kidney is restricted to below 200 ml/min, the time of blood purification treatment is caused to lengthen, be unfavorable for the carrying out of blood purification treatment, and increase blood purification treatment cost.
In addition, be limited to the maximum blood flow that perfusion device allows, after carrying out therapeutic alliance, have to first to pull down the pipeline be connected on perfusion device and be connected to dialyser again, carry out independent dialysis treatment.In this process, operator need to shut down, and pull down perfusion device and associated pipe, carry out blood back operation, in the process of dismounting perfusion device, need to disconnect blood circuit, carry out dismantling, the sequence of operations such as short circuit, and this adds the workload of operator clinically; And if operator have occurred misoperation in clinical manipulation process, blood samples of patients may be caused to lose, increase pathogenic bacteria invades the probability in blood samples of patients, increases patient painful, even can threaten to the life of patient.
Summary of the invention
Main purpose of the present invention is to provide a kind of apparatus for purifying blood simultaneously possessing hemoperfusion and hemodialysis function, to improve safety and the speed of blood purification treatment;
Another object of the present invention is to provide the blood purification system that more than one state apparatus for purifying blood structure.
In order to realize above-mentioned main purpose, apparatus for purifying blood provided by the invention comprises unit with dialysis, linkage unit and perfusion unit.Unit with dialysis comprises dialysis cartridge, and the import of unit with dialysis forms the blood inlet of apparatus for purifying blood.Linkage unit comprises front port, rear port and the open-close on-off for controlling connection therebetween, the port fixed seal connection of front port and the unit with dialysis port of export.Perfusion unit comprises adsorption column, along the axis of this adsorption column, the middle part of adsorption column filter chamber sidewall is provided with side through hole, and the port of this side through hole away from filter chamber and the rear port fixed seal connection of linkage unit, be provided with inlet screen between the rear port of linkage unit and filter chamber; One axial end of adsorption column is provided with the first outlet, and another axial end is provided with the second outlet, and this first outlet exports with the blood of the second export mixes apparatus for purifying blood.
From above scheme, integrally, tool possesses hemoperfusion and hemodialysis function to whole apparatus for purifying blood simultaneously, can provide better blood purification treatment for patient.In blood purification process, simple with the connected mode of transducer potector, while simplifying the operation, improve safety in utilization.By closed open-close on-off, the inner chamber environment of adsorption column and the inner chamber environment of dialysis cartridge are isolated, the adsorbent fragment that may exist in adsorption column is avoided to enter in dialysis cartridge, the dialysis function of dialyzer is impacted, by dialyzer and the different requirements of adsorbent to storage environment humidity, dry wet preservation can be realized accordingly simultaneously.The most important thing is, blood through dialysis cartridge dialysis enters in the filter chamber of adsorption column in the middle part of the sidewall of adsorption column, the absorption of the adsorbent of intracavity after filtration, apparatus for purifying blood is gone out from the outlet flow adsorption column two axial end after completing absorption, improve the maximum permissible value of the blood flow of whole adsorption column, thus improve the speed of therapeutic alliance, reduce the blood purification treatment time, in haemodialysis process, dialyse separately pipeline dismounting again occurred and connectivity problem again without the need to first therapeutic alliance, improve the safety of blood purification treatment.In addition, because adsorbent in whole adsorption column is for adopting with batch adsorbent and load simultaneously, the homogeneity flowing out blood purification effect from two axial end upper outlets is effectively guaranteed.
Concrete scheme is that an axial end port of adsorption column is closed by the first closing component, and another axial end port is closed by the second closing component; Away from the side of side through hole on the end face that first outlet is positioned at the first closing component; Away from the side of side through hole on the end face that second outlet is positioned at the second closing component.Be conducive to getting rid of the blood in adsorption column, reduce blood residuals amount.
Another concrete scheme is inlet screen is the spherical crown shape housing of one day away from the direction projection of linkage unit rear port.This spherical crown shape housing comprises containing portion and overflows mesh portion.Containing portion is the solid construction of the base section of this spherical crown shape housing, for splendid attire blood.Open end to the partial shell between containing portion of spherical crown shape housing is the spilling mesh portion be made up of filtering net plate.The degree of depth of containing portion is more than or equal to 1/6th of the internal diameter of spherical crown shape housing.Anti-Hemostatic Oral Liquid directly to enter on the sidewall relative with side through hole and directly to flow out from two axial ends outlets effectively, improves blood depuration efficiency, and effectively can balance and axially bring out from two the blood flow and clean-up effects that mouth flows out.
Another concrete scheme is also comprise the dividing plate be located in filter chamber, and filter chamber is separated into the first filter chamber and the second filter chamber by this dividing plate.Dividing plate is provided with several for being communicated with the intercommunicating pore of the first filter chamber and the second filter chamber.Middle face on block board thickness direction and the central axis of adsorption column mutually orthogonal, and the central axis of side through hole is arranged on this face.The adsorbent that dividing plate intercepts in filter chamber is effectively united towards an axial end gathering, effectively guarantees that on two axial ends, blood pressure is suitable, thus improves blood purification effectiveness and homogeneity.
Another concrete scheme is that linkage unit comprises sleeve and the interlayer board for barrel bore being separated into front port and rear port, and the centre in interlayer board plate face is provided with the via for conducting front port and rear port.Open-close on-off is located in via.Linkage unit structure is simple and effective.
Scheme is that the port of the dialysis cartridge port of export is fixedly connected with sleeve with the threaded engagement being located at female thread on front port medial surface by the external screw thread be located on its lateral surface more specifically.Side through hole has convexed to form ring-type coupled wall away from the port end face of filter chamber along the direction away from filter chamber, this ring-type coupled wall and side through hole coaxial arrangement, ring-type coupled wall is fixedly connected with sleeve with the threaded engagement being located at female thread on rear port medial surface by the external screw thread be located on its lateral surface.Be convenient to assemble apparatus for purifying blood.
Another concrete scheme is that the central axis of the central axis of dialysis cartridge and adsorption column is mutually orthogonal.
Another concrete scheme is that linkage unit comprises the first connection tube and the second connection tube.Open-close on-off comprises valve body and is placed in the spool in this valve body valve pocket, the sidewall of valve pocket is formed with the first through hole and the second through hole.The Single port of the first connection tube and the external port fixed seal connection of the first through hole, another port forms the front port of linkage unit.The Single port of the second connection tube and the external port fixed seal connection of the second through hole, another port forms the rear port of linkage unit.Spool comprises conducting pipeline, and by the rotation of spool around its rotating shaft, this conducting pipeline is communicated with the inner port of the first through hole and the inner port of the second through hole selectively.
Preferred scheme is the total capacity of adsorbent in adsorption column is 20 milliliters to 200 milliliters, and in dialysis cartridge, the gross area of dialyzer is 1.2 square metres to 2.0 square metres.
Another preferred scheme is that linkage unit also comprises for entering line-locked locking mechanism to the open/close states of open-close on-off, and the indicating mechanism for indicating the open/close states of open-close on-off.
In order to realize another object above-mentioned, blood purification system provided by the invention comprises blood transducer potector and is connected to the liquid purifier in this transducer potector.Wherein, the apparatus for purifying blood that provides for above-mentioned arbitrary technical scheme of apparatus for purifying blood.
Accompanying drawing explanation
Fig. 1 is the transducer potector connection diagram of existing blood purification system;
Fig. 2 is the transducer potector connection diagram of blood purification system first embodiment of the present invention;
Fig. 3 is the structural representation of apparatus for purifying blood in blood purification system first embodiment of the present invention;
Fig. 4 is the STRUCTURE DECOMPOSITION schematic diagram of apparatus for purifying blood in blood purification system first embodiment of the present invention;
Fig. 5 is A partial enlarged drawing in Fig. 4;
Fig. 6 is the view that in blood purification system first embodiment of the present invention, open-close on-off is in closedown;
Fig. 7 is the view that in blood purification system first embodiment of the present invention, open-close on-off is in unlatching;
Fig. 8 is the structural representation of perfusion unit in blood purification system second embodiment of the present invention;
Fig. 9 is the structural representation of perfusion unit in blood purification system of the present invention 3rd embodiment;
Figure 10 is the structural representation of perfusion unit in blood purification system of the present invention 4th embodiment;
Figure 11 is the structural representation of open-close on-off locking mechanism in blood purification system of the present invention 5th embodiment;
Figure 12 is the structural representation of blood purification system of the present invention 6th embodiment;
Figure 13 is the view that in blood purification system of the present invention 7th embodiment, open-close on-off is in closedown;
Figure 14 is the view that in blood purification system of the present invention 7th embodiment, open-close on-off is in unlatching.
Below in conjunction with embodiment and accompanying drawing thereof, the invention will be further described.
Detailed description of the invention
The present invention mainly improves the structure of apparatus for purifying blood in blood purification system, relate generally to the syndeton between adsorption column and dialysis cartridge, to improve blood purification treatment safety and speed, other part-structures of blood purification system design according to existing product.
Following embodiment mainly for blood purification system of the present invention, because blood purification system of the present invention have employed apparatus for purifying blood of the present invention, to the explanation of apparatus for purifying blood embodiment in the explanation of blood purification system embodiment.
Blood purification system first embodiment
Blood purification system is made up of blood circuit venous line three part flowing out the blood circuit arterial line of human body, apparatus for purifying blood and flow into human body.
See Fig. 2, in direction of flow of blood, blood circuit arterial line is provided with the arterial end 11, blood pump 12 and the tremulous pulse kettle 13 that are connected by pipeline successively, and on tremulous pulse kettle 13, be provided with tremulous pulse kettle side pipe 14; Blood circuit venous line is provided with the venous chambers 16 and vein end 18 that are connected by pipeline successively, and is provided with venous chambers side pipe 17 on venous chambers 16.
Apparatus for purifying blood 2 is made up of unit with dialysis 21, linkage unit 22 and perfusion unit 23.Apparatus for purifying blood 2 is connected with the rear port of blood circuit arterial line by the blood mouth on unit with dialysis 21, and is connected with the front port of blood circuit venous line by the blood mouth on perfusion unit 23.Blood circuit arterial line rear end is provided with safety clamp 15.
See Fig. 3 to Fig. 5, unit with dialysis 21 is for realizing the function of hemodialyzer in existing blood purification system, its main element is dialysis cartridge 211, the upper port of dialysis cartridge 211 is closed with end cap 212, the radial centre of the discoideus lid of end cap 212 is provided with blood mouth 2120, and blood mouth 2120 is for being connected with the rear port of blood circuit arterial line, and the port of blood mouth 2120 is closed with block, blood mouth 2120 forms the blood inlet of unit with dialysis 21, also forms the blood inlet of apparatus for purifying blood 2.The lower port of dialysis cartridge 211 is closed by end cap 213, and the radial centre of the discoideus lid of end cap 213 is provided with port 2130, and port 2130 forms the outlet of unit with dialysis 21.Accommodate dialyzer in the container cavity of dialysis cartridge 211, dialyzer can be the hemodialysis membrane of the materials such as polyether sulfone, polysulfones, polypropylene.Be provided with bonding glue-line 2112 at the both ends of dialysis cartridge 211 container cavity, between two bonding glue-lines 2112 and both being positioned at, side place is provided with dialysis solution outlet 2110 and dialysis solution import 2111.
The axial cross section of linkage unit 22 is an I-shaped structure, it has sleeve 220 and is located at the annular interlayer board 221 in the middle part of sleeve 220 inner chamber, sleeve pipe 220 is separated into upper and lower two ports by annular interlayer board 221, be respectively front port 223 and rear port 224, the endoporus being positioned at annular interlayer board 221 plate face centre is for the via 225 of conducting front port 223 with rear port 224, is provided with and opens closed open-close on-off 222 for controlling via 225 in via 225.Via 225 is the ring chamber that internal diameter is identical with the internal diameter of unit with dialysis 21 blood mouth with perfusion unit 23.Front port 223 medial surface is formed with the female thread for being fixedly connected with port 2130.The medial surface of rear port 224 is formed with the external screw thread for being fixedly connected with the entrance point of perfusion unit 23.
Open-close on-off is a butterfly valve, be made up of valve rod 2221 and the flap 2222 that is fixedly connected with valve rod 2221, flap 2222 is a discoideus structure and its profile matches with the medial surface to via 225, valve rod 2221 rotates around the central axis of valve rod 2221 for driving flap 2222, and then closes or open via 225.
Perfusion unit 23 is by adsorption column 231, first closing component 232, second closing component 233, and the adsorbent be placed in adsorption column 231 filter chamber 2310 is formed.Adsorbent can be the combination of one or more in the blood-purifying adsorbing agents such as resin sorbent, acticarbon, natural macromolecule adsorbent.
Along the axis of adsorption column 231, side through hole 235 is formed in the middle part of the sidewall of filter chamber 2310, side through hole 235 has convexed to form ring-type coupled wall 234 away from the port end face of filter chamber 2310, ring-type coupled wall 234 and side through hole 235 coaxial arrangement, the lateral surface of ring-type coupled wall 234 is formed with the external screw thread matched with the female thread on rear port 224.Side through hole 235 is fixed with inlet screen 2311 away from the port of rear port 224, and inlet screen 2311 is for preventing adsorbent from side through hole 225 outflow filter chamber 2310.
Upper two end faces of annular interlayer board 221 are equipped with sealing plain cushion mounting groove, for installing sealing plain cushion.Internal diameter, the external diameter of sealing plain cushion are all identical with annular interlayer board, after perfusion unit 23 and unit with dialysis 21 are of coupled connections with linkage unit 22 respectively, the end face of the outlet blood mouth of unit with dialysis 21 and the entrance blood mouth of perfusion unit 23 closely cooperates with sealing plain cushion respectively, thus realize unit with dialysis 21 and perfusion unit 23 respectively with linkage unit 22 fixed seal connection.
Because perfusion unit 23 is for realizing the function of blood perfusion device in existing blood purification system, in the present embodiment, closing component 211 is made up of filter screen, sealing plain cushion, end cap, locking nut and block.
Off-Radial centre on the end face of the end cap lid in the first closing component 232 and side away from side through hole 225 is provided with blood mouth 2320, blood mouth 2320 is for being connected with the front port of blood circuit venous line; Off-Radial centre on the end face of the end cap lid in the second closing component 233 and side away from side through hole 225 is provided with blood mouth 2330, blood mouth 2330 is for being connected with the front port of blood circuit venous line.Blood mouth 2330 forms the second outlet of perfusion unit 23, and blood mouth 2320 forms the first outlet of perfusion unit 23, and the two forms the blood outlet of apparatus for purifying blood 2 together.After completing blood purification treatment, blood in pipeline and adsorption column 231 needs backflow the Huis body, because the blood mouth on the end cap at adsorption column 231 two ends is arranged at the bottom away from entering blood mouth one end, so when carrying out blood back, blood in apparatus for purifying blood can total reflux the Huis body, and avoiding blood cannot drain and cause blood samples of patients to run off.
See Fig. 6, flap 2222 is driven to rotate by reversing valve rod 2221, thus the surface of flap 2222 is paralleled with the plate face of annular interlayer board 221, namely flap 2222 just blocks via 225, thus realize front port 223 and rear port 224 to separate, make adsorption column 231 mutually isolated with the inner chamber of dialysis cartridge 211.
See Fig. 7, by valve rod 2221 drive flap 2222 around valve rod 2221 axis 90-degree rotation, thus make the surface of flap 2222 mutually orthogonal with the plate face of annular interlayer board 221, namely flap 2222 no longer blocks via 225, thus realizes front port 223 and rear port 224 to be interconnected by via 225.
The assembling process of apparatus for purifying blood 2 is as follows:
(1) respectively perfusion unit 23 and unit with dialysis 21 are pre-installed;
(2) open-close on-off 222 on linkage unit 22 is closed, sealing plain cushion is mounted on the sealing plain washer mounting groove on linkage unit 22 annular interlayer board 221 respectively, make the ring-type coupled wall 234 of perfusion unit 23 along gravity direction upward, by threaded engagement, ring-type coupled wall 234 is fixedly connected with the rear port 224 of linkage unit 22, after coupling puts in place, sealing plain cushion and the end face compression fit of ring-type coupled wall 234, thus be sealed and matched for the two connection provides; By threaded engagement, front port 223 is fixedly connected with port 2130, after coupling puts in place, sealing plain cushion and the end face compression fit of port 2130, thus be sealed and matched for the two connection provides; Apparatus for purifying blood 2 after completing assembling, the central axis of dialysis cartridge 211 and the central axis of adsorption column 231 mutually orthogonal.
(3) after the assembling completing apparatus for purifying blood, sterilizing is carried out to whole apparatus for purifying blood and packs.
Linkage unit 22 is for connecting unit with dialysis 21 and perfusion unit 23, in storage after completing production and transportation, open-close on-off 222 is in closure state all the time, and to be on the one hand the adsorbent fragment that prevents from may existing in adsorption column 231 close 222 by inlet screen 2311 and shear-blade enters in dialysis cartridge 211 and damage dialyzer; That adsorption column 231 may be different from the storage mode of dialysis cartridge 211 on the other hand, such as dialysis cartridge 211 is inner is dry state preservation, and the inside of adsorption column 231 is hygrometric state preservation, or the two is contrary, thus the two inside is isolated, effectively guarantee safety and the effectiveness of apparatus for purifying blood 2.
Before carrying out blood purification treatment, first rush in advance apparatus for purifying blood 2, pre-punching method is as follows:
Along gravity direction, unit with dialysis 21 is positioned at top, perfusion unit 23 is positioned at below, after connecting pipeline, rush liquid in advance and inject apparatus for purifying blood 2 from the blood mouth 2120 of unit with dialysis 21, through dialysis cartridge 211 and linkage unit 22, then adsorption column 231 is entered, exported by first outlet and second of absorbing unit 23 again and flow out, rush liquid in advance first to rush in advance adsorbent again after dialyzer, prevent the adsorbent fragment in adsorption column 231 from entering in dialysis cartridge 211 with rushing liquid in advance, the liquid that rushes in advance through perfusion unit 23 is avoided to pollute dialyzer, to guarantee safety and the effectiveness of apparatus for purifying blood 2.
When treating, blood enters in apparatus for purifying blood 2 from the blood mouth 2120 unit with dialysis 21, the Dialysis of dialyzer in dialysis cartridge 211, then enter in the filter chamber of adsorption column 231, through the adsorption of filter chamber 2310 internal adsorption agent, from the outlet flow blood back liquid pipeline two axial ends.Because the blood entered in adsorption column 231 is divided into two parts to flow to two axial end upper outlets, substantially be equivalent to use two adsorption columns to carry out adsorption simultaneously simultaneously, increase the maximum permissible value of whole adsorption column 231 blood flow, and then improve blood purification speed, and the operation such as detaching pipelines of independent dialysis treatment is in use carried out again without the need to first therapeutic alliance, reduce the operating time and therefore brought security risk can be avoided.
In the present embodiment, front port 223 and rear port 224 internal diameter of linkage unit 22 elect 4 millimeters to 15 millimeters as, are preferably 4 millimeters to 8 millimeters.In adsorption column 231, the total capacity of adsorbent is 20 milliliters to 200 milliliters, and be preferably 20 milliliters to 130 milliliters, in dialysis cartridge 211, the gross area of dialyzer is 1.2 square metres to 2.0 square metres.
Blood purification system second embodiment
As the explanation to blood purification system second embodiment of the present invention, only the difference with blood purification system first embodiment is described below.
See Fig. 8, inlet screen 3311 is the spherical crown shape housing to the direction projection away from ring-type coupled wall 334, this spherical crown shape housing is half spherical shell structure, this hemispherical configuration base section is solid construction, namely mesh is not provided with, mesh is located in the above partial sidewall of spherical crown, the spacing at mesh and hemispherical Shell structure medial surface minimum point place is more than or equal to 1/6th of the internal diameter of this hemispherical Shell structure, namely the degree of depth of solid construction part is more than or equal to 1/6th of the internal diameter of hemispherical Shell structure, after making blood enter the bottom of inlet screen 3311, adsorb by there being mesh to overflow to enter in filter chamber 33101 again, effectively avoid the blood of high flow rate directly to enter bottom adsorption column 331 and flow out from the outlet adsorption column 331 liang of axial ends, blood is fully contacted with the adsorbent in perfusion unit 23, to improve adsorption effect.Solid construction part forms the containing portion of inlet screen 3311, and the part being located at mesh forms the spilling mesh portion of inlet screen 3311, and it is surrounded by filtering net plate.
Blood purification system the 3rd embodiment
As the explanation to blood purification system of the present invention 3rd embodiment, only the difference with blood purification system second embodiment is described below.
See Fig. 9, the cross section of the inlet screen 4311 in adsorption column 431 is V-structure, and the mesh on its sidewall and the spacing of its sharp corner are more than or equal to 1/3rd of the V-structure degree of depth.
Blood purification system the 4th embodiment
As the explanation to blood purification system of the present invention 4th embodiment, only the difference with blood purification system second embodiment is described below.
See Figure 10, dividing plate 5312 is provided with in adsorption column 531, filter chamber 5310 is separated into two sub-filter chambers by dividing plate 5312, be respectively the first filter chamber 53101 and the second filter chamber 53102, middle face on dividing plate 5312 thickness direction and the central axis of adsorption column 531 mutually orthogonal, and the central axis of side through hole 535 is arranged on this face.Dividing plate 5312 is mainly used in making the adsorbent in adsorption column 531 both ends remain in original space and not flow to the other end.The mesh of dividing plate 5312 is 300 microns to 600 microns.Preferred employing polypropylene, Merlon or SBS material injection form, and then it is inner to be adopted by dividing plate 5312 modes such as bonding, welding to be fixed on adsorption column 531, it has the advantages such as good permeability, hardness strength be larger, and can meet the demand supporting and separate adsorbent, and when can avoid rushing in advance, adsorption column 531 internal gas is difficult to the problem of discharging.Dividing plate 5312 and inlet screen 5312 part that contacts adopts and to weld or bonding mode is fixed connection.
Dividing plate 5312 is sieve-plate structure, thus make the adsorbent capacity in adsorption column 531 both ends in blood purification process, keep suitable, in avoiding adsorbent under the impact of liquid, an end is concentrated wherein, guarantee that the blood pressure at dialysis cartridge 531 two ends is suitable, make when velocity of blood flow is higher, the pressure of perfusion unit 23 inside is still in preset range, perfusion unit 23 inside is avoided to occur the problem such as blood coagulation or haemolysis, ensure adsorbent safety and effectiveness over the course for the treatment of, guarantee therapeutic effect.
Blood purification system the 5th embodiment
As the explanation to blood purification system of the present invention 5th embodiment, only the difference with blood purification system first embodiment is described below.
Linkage unit also has locking mechanism and indicating mechanism.
See Figure 11, locking mechanism is by elastic component, latch 62, shadoof 64 and coaxial with valve rod and to be fixedly connected with and coaxially arranged locking wheel 61 is formed, elastic component is spring 63, the circumference of locking wheel 61 is formed with the first lock slots 611 and the second lock slots 612 radially arranged.Spring 63 one end is connected on latch 62, and the other end is fixedly connected on linkage unit; Shadoof 64 is fixedly connected on latch 62 one end near spring 63.When switching open-close on-off, need first pull shadoof 64, make the first lock slots 611(in locking wheel 61 as closed condition) be separated with latch 62, then rotary valve rod, after decontroling shadoof 64, under the effect of spring 63 restoring force, latch 62 inserts the second lock slots 612(of locking wheel 61 as open mode) in, thus make open-close on-off from the first state as open mode switches to the second state as closed, and complete the locking to valve rod by locking mechanism.When needs switch to the first state from the second state, same first pulls shadoof 64, and then opposite direction rotary valve rod, and the open/close states realizing open-close on-off switches.Locking mechanism is avoided effectively in transport and storing process under unartificial External Force Acting, and open-close on-off is opened, or is closed in blood purification process, thus produces unnecessary impact.
Indicating mechanism is made up of the keying indicating graduation portrayed on sleeve lateral surface and the instruction of portraying on valve rod.
Blood purification system the 6th embodiment
As the explanation to blood purification system of the present invention 6th embodiment, only the difference with blood purification system first embodiment is described below.
See Figure 12, the linkage unit 8 be connected between unit with dialysis 7 and perfusion unit 9 is made up of the first connection tube 81, valve 82, rotating shaft 83 and the second connection tube 84, the upper port of the first connection tube 81 is configured for the front port with the port of export port fixed seal connection of unit with dialysis, and the lower port of the second connection tube 84 forms the rear port with the entrance point port fixed seal connection of perfusion unit.
Valve 82 is made up of the spool 822 of round pie and valve body 821, and valve body 821 is formed with the valve pocket matched with spool 822, and the outer peripheral face of spool 822 and the inner peripheral surface of valve pocket are sealed and matched mutually.
The end face of the lower port 811 of the first connection tube 81 and the upper port 841 of the second connection tube 84 is arcwall face structure, and these two ports are by being located at the first through hole on holding tank sidewall and the second through hole is communicated with holding tank, spool 822 is provided with guide pipeline 8221, and the two-port of conducting pipeline 8221 is port 82211 and port 82212.
By the side by rotating shaft 83 valve 82 being fixed on the first connection tube 81 and the second connection tube 84.
As shown in figure 12, conduction pipe is led 8221 two ends ports and is not all docked with lower port 811 and upper port 841, and now open-close on-off is in closed condition.Make spool 822 revolve turnback around rotating shaft 83, thus port 82211 is docked with upper port 841, port 82212 docks with lower port 811, thus realizes the unlatching of open-close on-off.
Blood purification system the 7th embodiment
As the explanation to blood purification system of the present invention 7th embodiment, only the difference with blood purification system first embodiment is described below.
See Figure 13 and Figure 14, open-close on-off is a stop valve, this stop valve is made up of flap 9251, nut casing 9252, valve rod 9253 and handle 9254, handle 9254 is fixedly connected with one end of valve rod 9253, valve rod 9253 other end end lateral surface is formed with the external screw thread matched with nut casing 9252 female thread, and flap 9251 is fixedly connected with nut casing 9253 one end away from valve rod 9253.
By rotary handle 9254, by the effect of helicitic texture, drive flap 9251 moving axially along valve rod 9253, thus block the via 924 be located on annular interlayer board or away from via 924, realize the control of the open and close to via 924.
Central scope of the present invention is by improving the syndeton of dialysis cartridge in apparatus for purifying blood and adsorption column, the outlet of dialysis cartridge is made to carry out being communicated with of control able to turn on or off with the supermedial side through hole of adsorption column sidewall, after absorption, blood flows out from the outlet adsorption column two axial end, to improve safety and the speed of blood purification treatment.According to the present invention's design, the structure of inlet screen and the structure of linkage unit also have multiple apparent change.
Claims (11)
1. apparatus for purifying blood, comprises unit with dialysis, perfusion unit and linkage unit:
Described unit with dialysis comprises dialysis cartridge;
Described perfusion unit comprises adsorption column;
It is characterized in that:
The import of described unit with dialysis forms the blood inlet of described apparatus for purifying blood;
Described linkage unit comprises front port, rear port and for controlling the open-close on-off be communicated with between described front port with described rear port, the port fixed seal connection of the port of export of described front port and described unit with dialysis;
Along the axis of described adsorption column, the middle part of the sidewall of the filter chamber of described adsorption column is provided with side through hole, and described side through hole, away from the port of described filter chamber and described rear port fixed seal connection, is provided with inlet screen between described rear port and described filter chamber;
One axial end of described adsorption column is provided with the first outlet, and another axial end is provided with the second outlet, and described first outlet exports with the blood of apparatus for purifying blood described in described second export mixes.
2. apparatus for purifying blood according to claim 1, is characterized in that:
The port of one axial end of described adsorption column is closed by the first closing component, and the port of another axial end is closed by the second closing component;
Away from the side of described side through hole on the end face that described first outlet is positioned at described first closing component; Away from the side of described side through hole on the end face that described second outlet is positioned at described second closing component.
3. apparatus for purifying blood according to claim 1, is characterized in that:
Described inlet screen is towards the spherical crown shape housing away from the direction projection of described rear port;
Described spherical crown shape housing comprises containing portion and overflows mesh portion;
Described containing portion is the solid construction of the base section of described spherical crown shape housing, for splendid attire blood;
The open end of described spherical crown shape housing is the described spilling mesh portion be made up of filtering net plate to the partial shell between described containing portion;
The degree of depth of described containing portion is more than or equal to 1/6th of the internal diameter of described spherical crown shape housing.
4. apparatus for purifying blood according to claim 1, is characterized in that:
Also comprise the dividing plate be located in described filter chamber, described filter chamber is separated into the first filter chamber and the second filter chamber by described dividing plate;
Described dividing plate is provided with several for being communicated with the intercommunicating pore of described first filter chamber and described second filter chamber;
Middle face on the thickness direction of described dividing plate and the central axis of described adsorption column mutually orthogonal, and the central axis of described side through hole is arranged on described.
5. apparatus for purifying blood according to claim 1, is characterized in that:
Described linkage unit comprises sleeve and the interlayer board for the inner chamber of described sleeve being separated into described front port and described rear port, and the centre in the plate face of described interlayer board is provided with the via for front port described in conducting and described rear port;
Described open-close on-off is located in described via.
6. apparatus for purifying blood according to claim 5, is characterized in that:
The port of the port of export of described dialysis cartridge is fixedly connected with described sleeve with the threaded engagement of the female thread on the medial surface being located at described front port by the external screw thread be located on its lateral surface;
Described side through hole has convexed to form ring-type coupled wall away from the end face of the port of described filter chamber along the direction away from described filter chamber, described ring-type coupled wall and described side through hole coaxial arrangement, described ring-type coupled wall is fixedly connected with described sleeve with the threaded engagement of the female thread on the medial surface being located at described rear port by the external screw thread be located on its lateral surface.
7. apparatus for purifying blood according to claim 1, is characterized in that:
The central axis of described dialysis cartridge and the central axis of described adsorption column mutually orthogonal.
8. apparatus for purifying blood according to claim 1, is characterized in that:
Described linkage unit comprises the first connection tube and the second connection tube;
Described open-close on-off comprises valve body and is placed in the spool in the valve pocket of described valve body, the sidewall of described valve pocket is formed with the first through hole and the second through hole;
The Single port of described first connection tube and the external port fixed seal connection of described first through hole, another port is described front port;
The Single port of described second connection tube and the external port fixed seal connection of described second through hole, another port is described rear port;
Described spool comprises conducting pipeline, and by the rotation of described spool around its rotating shaft, described conducting pipeline is communicated with the inner port of described first through hole and the inner port of described second through hole selectively.
9. apparatus for purifying blood according to any one of claim 1 to 8, is characterized in that:
In described adsorption column, the total capacity of adsorbent is 20 milliliters to 200 milliliters, and in described dialysis cartridge, the gross area of dialyzer is 1.2 square metres to 2.0 square metres.
10. apparatus for purifying blood according to any one of claim 1 to 8, is characterized in that:
Described linkage unit also comprises for entering line-locked locking mechanism to the open/close states of described open-close on-off, and the indicating mechanism for indicating the open/close states of described open-close on-off.
11. blood purification systems, comprise transducer potector and are connected to the apparatus for purifying blood in described transducer potector;
It is characterized in that:
Described apparatus for purifying blood is apparatus for purifying blood described in any one of claim 1 to 10.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112451772A (en) * | 2020-12-21 | 2021-03-09 | 南通大学附属医院 | But real-time supervision's blood purification device |
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| CN105214157B (en) | 2017-06-30 |
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Address after: 519080 Zhuhai hi tech Zone No. six road, Guangdong Province, 98 Patentee after: Jianfan Biotechnology Group Co., Ltd. Address before: 519080 Zhuhai hi tech Zone No. six road, Guangdong Province, 98 Patentee before: Jafron Biomedical Co., Ltd. |