CN105194364A - Medicinal composition for local burn nursing - Google Patents
Medicinal composition for local burn nursing Download PDFInfo
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Abstract
The invention discloses a medicinal composition for local burn nursing. The medicinal composition comprises caffeic acid, gentisic acid, beta-sitosterol, triclosan, palmitic acid, beta-chitosan, glutamic acid, ethyl acetate, methionine, Chinese medical extract, Chinese medicinal super micropowder and accessories, wherein raw materials of the Chinese medical extract comprise chlorophytum comosum, kalopanax, lonicera pampaninii, barks of Indian quassiawood, licorice, lycopus lucidus, eurya chinensis roots, eucalyptus robusta, pilea lomatogramma hand.-mazz, hibiscus trionum, abutilon indicum, championella sarcorrhiza, folium broussonetiae, bittersweet herb, dischidia minor, green lilies and radishes; raw materials of the Chinese medicinal super micropowder comprise psychotria serpens, whiteflower leadwood roots, rust powder made of iron and acetic acid, henon bamboo juvenile leaves, umbilicaria esculenta, pternopetalum botrychioides, herbs of shiny cinquefoil and passiflora henryi hemsl; the accessories comprise glycerin, sodium alginate, a preservative, an anti-oxidation reinforcing agent, a surfactant, a stabilizer, an isotonic regulator and injection water. According to the medicinal composition, multiple Chinese herbal medicaments are combined, so that the medicinal composition has the effects of clearing heat, removing toxicity, cooling blood, protecting the heart, removing dampness, nourishing yin, reinforcing qi, nourishing blood and resisting bacteria and viruses, and is free of irritation to skin, burn infection can be effectively treated, and wound healing can be accelerated.
Description
Technical field
The present invention relates to medical nursing technique field, specifically relate to a kind of pharmaceutical composition for localized burn nursing.
Background technology
The natural screening that burnt degree skin resists microorganism invasion as human body is destroyed, and the skin histology of necrosis is again good " culture medium " of microbial growth.Therefore, burn wound very easily infects.In recent years, due to the raising of Burn shock Level of first-aid treatment, shock death rate obviously declines.And burn infection becomes the major causes of death of serious burn.The control of burn infection is the key of burn treating.The common bacteria of infection is caused to be S. aureus L-forms, bacillus pyocyaneus, Citrobacter freundii, nitrate-negative bacillus and other intestinal negative bacillus.Also may there is viral infections, anaerobe and viral infection in serious burn.
The infection of burn wound can cause wound to be difficult to the failure etc. of healing or large area is made skin graft, so must handle the infection problems of burned part well.The local application of burn wound mainly comprises antibacterial medicine for external use and antifungal medicine for external use, and other external application Chinese medicine water decoction, as the medicine such as Cortex Phellodendri, Radix Sophorae Tonkinensis decocting liquid.
Western medicine antibiotics is because of its determined curative effect, and now having become control severe infections must obligato medicine.While Antibiotics kill human body pathogenic bacteria, also kill other non-pathogenic bacterias (comprising some probiotic bacterias), thus destroy the balance of normal flora in human body, cause Flora Disturbance, cause insensitive antibacterial or fungus amount reproduction; And western medicine antibiotics mostly is single action target spot, and antibacterial easily produces drug resistance, antibiotic is caused to lose efficacy; In addition, western medicine antibiotics also has a lot of toxic and side effects, and can cause anaphylaxis, and therefore, the application of western medicine antibiotics exists a lot of drawback.
Traditional Chinese medicine active site mostly is mixture, can play synergism between each active component, even if the pathogen of variation is also difficult to the road finding existence in the antibacterial atmosphere of this complexity; And the medicine of existing treatment by Chinese herbs burn infection has bactericidal effect bad, not obvious to drug tolerant bacteria effect, because wound can not the moisturizing defects such as debridement is more painful, administration is not too convenient that make wound surface easily form a scab.
Summary of the invention
The technical problem that the present invention solves is
Technical scheme of the present invention is, a kind of pharmaceutical composition for localized burn nursing, comprise following component: 0.2 ~ 2% caffeic acid, 1 ~ 3% gentisic acid, 0.5 ~ 2.5% cupreol, 0.04 ~ 0.06% triclosan, 0.3 ~ 1.0% Palmic acid, 5 ~ 7% β-chitosan, 1 ~ 2.4% glutamic acid, 2 ~ 2.5% ethyl acetate, 0.04 ~ 0.1% methionine, 4 ~ 10% Chinese medical concretes, 2 ~ 5% Chinese medicine ultra-fine powders, also comprise the Adeps Felis domestica of 0.3 ~ 0.6%, surplus is adjuvant;
Described Chinese medical concrete is extracted respectively by following two groups of Chinese herbs to make:
A group is counted by weight: 20 ~ 30 parts of Herba Chlorophyti Comosi, 5 ~ 10 portions of Kalopanax septemlobums, 10 ~ 22 parts of Flos Lonicerae pampaininiis, 8 ~ 20 parts of Ramulus et Folium Pcrasmae (Cortex Picrasmae)s, 6 ~ 15 portions of Radix Glycyrrhizaes, 5 ~ 15 parts of Herba Lycopi, 9 ~ 15 portions of Radix Euryae Chinensis roots, 30 ~ 45 portions of Folium Eucalypti Robustae;
B group is counted by weight: 16 ~ 30 parts of Pilea lomatogramma Hand.-Mazz, 9 ~ 15 parts of Herba hibisci trionis, 7 ~ 10 parts of bar cling to flower, 30 ~ 40 parts of Strobilanthes sarcorrhizus Cling, 20 ~ 44 parts of Folium Broussonetiae, 3 ~ 10 parts of Herba Solani Lyratis, 6 ~ 9 parts of Dischidia minor (Vahl) Merr, 3 ~ 5 parts of green Bulbus Liliies, 12 ~ 30 portions of Radix Raphanis;
It is be made up of following Chinese herb that described Chinese medicine ultra-fine powder is counted by weight: 10 ~ 15 parts of Ramulus et Folium Psychotriae Serpentis, 12 ~ 18 portions of Radix Plumbaginis Zeylanicaes, 4 ~ 7 parts of Magnetite, 15 ~ 30 parts of Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendles, 6 ~ 10 parts of Umbillcaria esculentas, 20 ~ 25 parts of loose blood celerys, 16 ~ 30 parts of Herba potentillae fulgentis, 8 ~ 15 parts of swallow tails;
Described adjuvant is counted by weight and is comprised: 5 ~ 8 parts of glycerol, 0.5 ~ 1.5 part of sodium alginate, 0.002 ~ 0.01 portion of antiseptic, 0.02 ~ 0.05 part of antioxidation reinforcing agent, 0.001 ~ 0.015 part of surfactant, 0.3 ~ 1.0 part of stabilizing agent, 2 ~ 2.8 parts of isoosmotic adjusting agent, 55 ~ 80 parts of waters for injection.
Further, described antiseptic is benzalkonium chloride or benzylalcohol, preferred benzalkonium chloride, and benzalkonium chloride not only can be used as antiseptic and uses, and also plays the effect of sterilization in pharmaceutical composition of the present invention, and low concentration uses no skin irritation.
Further, described antioxidation reinforcing agent is tartaric acid, prevents oxidation of drug from going bad.
Further, described surfactant is selected from cetylpyridinium chloride (CPC) or Tween 80, cetylpyridinium chloride (CPC) has good surface activity and sterilizing performance, and Tween 80 belongs to nonionic surfactant, has good emulsification.
Further, described stabilizing agent is poloxamer188, not only has Stabilization, can also increase the surface dissolution degree of multi-medicament, good with skin intermiscibility, increases cutaneous permeability, can promote the absorption of topical agent.
Further, described isoosmotic adjusting agent is borate buffer solution, makes osmotic pressure inside and outside skin keep balance, prevents wound surface Skin Cell serosity to run off.
Further, described a kind of pharmaceutical composition for localized burn nursing, its preparation method is as follows:
(1) Chinese medical concrete is prepared:
A group Chinese herb is taken: Herba Chlorophyti Comosi, Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Euryae Chinensis root, Radix Glycyrrhizae, Herba Lycopi, Folium Eucalypti Robustae, Kalopanax septemlobum, Flos Lonicerae pampaininii by described weight proportion, be crushed to 80 ~ 100 orders, merceration 1h, 2.5 ~ 3.5h is decocted with water by solid-to-liquid ratio 1: 14 ~ 20, after gained decoction liquor is filtered, concentrating under reduced pressure become relative density be 0.85 ~ 1.05 extractum, obtain extractum a;
B group Chinese herb is taken: Pilea lomatogramma Hand.-Mazz, Herba hibisci trioni, Ba Bahua, Strobilanthes sarcorrhizus Cling, Folium Broussonetiae, Herba Solani Lyrati, Dischidia minor (Vahl) Merr, green Bulbus Lilii, Radix Raphani by described weight proportion, with an organic solvent extract, extract is condensed into the extractum that relative density is 0.85 ~ 1.05, obtains extractum b;
Above-mentioned obtained extractum a and extractum b is merged, namely obtains described Chinese medical concrete;
(2) Chinese medicine ultra-fine powder is prepared:
Ramulus et Folium Psychotriae Serpentis, Radix Plumbaginis Zeylanicae, Magnetite, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle, Umbillcaria esculenta, loose blood celery, Herba potentillae fulgentis, swallow tail is taken by described weight proportion, first be ground into coarse powder with pulverizer, be placed in the micropowder that jet mill is ground into 1 ~ 50 μm again, namely obtain described Chinese medicine ultra-fine powder;
(3) sodium alginate is dispersed in the mixture of glycerol and Adeps Felis domestica, the water for injection adding 1/3 dissolves, be stirred well to the solution forming homogenizing, add Chinese medical concrete, Chinese medicine nano powder, antiseptic, antioxidation reinforcing agent, surfactant, stabilizing agent, isoosmotic adjusting agent again, and remaining 2/3 water for injection, limit edged stirs, sterilizing, subpackage, to obtain final product.
Further, the organic solvent in described step (1) be selected from methanol, ethanol, acetone, ethyl acetate, n-butyl alcohol, chloroform, dichloromethane any one.
Further, the sterilizing methods in described step (3) is high pressure steam sterilization.
Medicinal raw material pharmacologically active selected by the present invention is:
Herba Chlorophyti Comosi: [nature and flavor] sweetness and bitterness is flat.[function cures mainly] relieving cough and resolving phlegm, subduing swelling and detoxicating, synthetism of invigorating blood circulation.Control tracheitis cough with copious phlegm, carbuncle furuncle, swelling and pain of hemorrhoid, fracture, burn.Adeps Felis domestica: [nature and flavor] sweet in the mouth; Micro-salty; Property flat [function cures mainly] removing toxic substances and promoting granulation.Main burn and scald.Loose blood celery: [nature and flavor] mildly bitter flavor; Pungent; Cold nature [function cures mainly] hemostasia and detumescence; Removing toxic substances.Operator wound is hemorrhage; Burn; Scald.Ramulus et Folium Pcrasmae (Cortex Picrasmae): [nature and flavor] are bitter is flat.Slightly poisonous.[function cures mainly] heat clearing and damp drying, removing toxic substances parasite killing.Control bacillary dysentery, gastroenteritis, biliary tract infection, ascariasis, acute festering type infects, scabies, eczema, burn.Radix Euryae Chinensis root: [nature and flavor] micro-hardship; Cool [function cures mainly] heat-clearing and toxic substances removing sore.Main sore swollen toxin; Burn; Scald.Pilea lomatogramma Hand.-Mazz: [nature and flavor] sweet in the mouth; Bitter; [function cures mainly] cold in nature stasis-dispelling and pain-killing; Removing toxic substances sore.Main traumatic injury; Empyrosis.Umbillcaria esculenta: [function cures mainly] nourishing YIN and moistening the lung; Cooling blood for hemostasis; Heat-clearing and toxic substances removing.Main deficiency of the lung phthisical cough; Spit blood; Epistaxis; Metrorrhagia; Discharging fresh blood stool; Anal fistula; Proctoptosis; Stranguria with turbid discharge; Leukorrhagia; Venom; Scald and knife injury.Herba hibisci trioni: [nature and flavor] herb: sweet, cold.[function cures mainly] herb: heat-clearing and toxic substances removing, expelling wind and removing dampness, cough-relieving, diuresis.For acute arthritis, cold cough, enteritis, dysentery; Burn and scald is controlled in external, sore.Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle: [function cures mainly] to clear away heart-fire relieving restlessness, relieve heat and thirst.1. " the SHENGCAO property of medicine is standby to be wanted ": " control burn, charred medicinal herb with its property retained oil is adjusted and put on the skin." 2. " book on Chinese herbal medicine is new again ": " clearing heart fire, removing toxic substances relieving restlessness, summer heat relieving and dampness eliminating, slakes thirst and help produce saliva." Ba Bahua: [nature and flavor] are light; Flat [function cures mainly] heat-clearing and toxic substances removing.Main cold, fever; Parotitis; Thyromegaly; Neurasthenia; Dysuria; Furuncle; Tinea pedis and tinnitus.Strobilanthes sarcorrhizus Cling: [nature and flavor] are micro-sweet, cool.[function cures mainly] stem, leaf: heat-clearing and toxic substances removing.For acute infectious hepatitis; Furuncle furuncle and phyma is controlled in external, and tendon is sprained.Radix Glycyrrhizae: [nature and flavor] are sweet, flat.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Folium Broussonetiae: [nature and flavor] are sweet, cool.The acetone extract of antibacterial action Folium Broussonetiae has inhibitory action [function cures mainly] removing heat from blood to staphylococcus, diuretic.Control haematemesis, epistaxis, metrorrhagia, traumatic hemorrhage, edema, hernia, dysentery, tinea skin ulcer.Herba potentillae fulgentis: [nature and flavor] are " the southern regions of the Yunnan Province book on Chinese herbal medicine " 1.: " cold in nature, bitter and puckery flavor." [function cures mainly] heat clearing and inflammation relieving, cooling blood for hemostasis.Control dysentery, enteritis, stomachache, hemoptysis of pulmonary tuberculosis, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, furuncle.Magnetite/Ferrous acetate: [nature and flavor] are " Kaibao Bencao " 1.: " salty in the mouth is flat, nontoxic." [function cures mainly] nourishing blood to tranquillize the mind, reinforcing the heart suppressing the hyperactive liver.Control blood deficiency, palpitation with fear, forgetful, epilepsy disease, Xuan tinea, proctoptosis anal fistula.Herba Solani Lyrati: [nature and flavor] are bitter, are slightly cold.Slightly poisonous.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis and reducing edema, anticancer.Herb: for cold, fever, acute mastitis, malignant boil, jaundice due to damp-heat, ascites, leucorrhea, oedema due to nephritis; Carbuncle furuncle and phyma poison is controlled in external.Root: rheumatic arthralgia.Kalopanax septemlobum: [nature and flavor] are pungent, flat.Slightly poisonous.[function cures mainly] expelling wind and removing dampness, promoting blood circulation and stopping pain.For rheumatism soreness of waist and knee joint, oedema due to nephritis, traumatic injury, internal pile hematochezia.Radix Plumbaginis Zeylanicae: [nature and flavor] root: sweet, micro-hardship is cool.[function cures mainly] root: induce sweat and bring down a fever, removing toxic substances relieving restlessness.For cold, fever, restlessness and thirst, malaria, lumbago and skelalgia, lyssodexis, venom.Leaf: traumatic hemorrhage is controlled in external.Dischidia minor (Vahl) Merr: [nature and flavor] mildly bitter flavor; [function cures mainly] cool in nature clearing away heat and cooling blood; YIN nourishing and the production of body fluid promoting.Main consumption of body fluid caused by high fever; Thirst with desire to drink; Conjunctival congestion and swelling pain external.Green Bulbus Lilii: [nature and flavor] are sweet; Micro-hardship; Cool [function cures mainly] nourishing YIN and moistening the lung; Clearing away heart-fire for tranquillization.Main cough due to yin deficiency; Fidgets due to deficiency is palpitated with fear; Insomnia and dreamful sleep; Absentminded; Carbuncle; Eczema.Radix Raphani: [nature and flavor] Xin Gan, cool, alcohol extract has antibacterial action, particularly more responsive to gram-positive bacterium, also can antifungal [function cures mainly] removing food stagnancy stagnant, heat of reducing phlegm, the therapeutic method to keep the adverse QI flowing downwards, alleviating distention in middle-JIAO, removing toxic substances.External treatment skin infection; Damage congestive edema; Scald and chilblain.Herba Lycopi: [nature and flavor] bitter in the mouth; Pungent; Slightly warm in nature [function cures mainly] blood circulation promoting and blood stasis dispelling; Line water detumescence; Removing toxicity for eliminating carbuncles.Housewife female's amenorrhea; Dysmenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen edema; Traumatic injury; Carbuncle sore tumefacting virus treating snakebite, loose skin infection, " Japan hanako materia medica ": " nourish blood gas for logical nine orifices, sharp GUAN-pulse, broken stagnated blood.Flos Lonicerae pampaininii: [function cures mainly] sterilizes.Swallow tail: [function cures mainly] invigorating the lung and benefiting vital QI, antiinflammatory, sterilization.Folium Eucalypti Robustae: [nature and flavor] micro-pungent, micro-hardship, flat.Folium Eucalypti Robustae antimicrbial power is comparatively strong, and antimicrobial spectrum is also wide.Folium Eucalypti Robustae water decoction all has inhibitory action to staphylococcus aureus, streptococcus pneumoniae, sarcina, alpha streptococcus, neisser's coccus, dysentery bacterium, bacillus pyocyaneus, escherichia coli, Bacillus typhi, Salmonella paratyphi.Ramulus et Folium Psychotriae Serpentis: [nature and flavor] toil is flat.[function cures mainly] stem, leaf: antiinflammatory, removing toxic substances, removing the necrotic tissue, synthetism, wind-damp dispelling, controls and gets injured by a fall.Wind-expelling pain-stopping, relaxing muscles and tendons and activating QI and blood in the collateral.
Caffeic acid has bacteriostasis more widely, has antiviral activity, prevents hemorrhage or hemostasis.Triclosan is killed and inhibitory action widely to causing infection or pathogenicity Gram positive mattress, true mattress, yeast and virus etc. all to have.To no skin irritation.Effective suppression noxious bacteria: escherichia coli, staphylococcus aureus, Candida albicans, can protect beneficial bacteria simultaneously.Gram positive bacteria, negative bacterium, yeast and virus are all killed and inhibitory action.Isopropyl ester stearic acid has good immersional wetting and nonirritant to skin.Glutamatergic blood vessel dilating, strengthens blood circulation, has certain trophic function to skin.
The invention has the beneficial effects as follows: the present invention is by rational compatibility Chinese medicine medicines, heat-clearing and toxic substances removing can be reached, removing heat from blood protects the heart, dampness removing yin nourishing, benefiting QI and nourishing blood effect, and employ several with Chinese herbal medicine without interactional western medicine composition, can antibacterial, antiviral, bacteriostasis and sterilization effect broad-spectrum, effect is strong, uses checking, all have killing effect to various bacteria and virus through reality; Not only to intact skin histology nonirritant, and to damaged skin also without obvious stimulation effect, effectively treat burn infection, accelerate wound healing.
Detailed description of the invention
Embodiment 1:
A kind of pharmaceutical composition for localized burn nursing, comprise following component: 0.2% caffeic acid, 1% gentisic acid, 0.5% cupreol, 0.04% triclosan, 0.3% Palmic acid, 5% β-chitosan, 1% glutamic acid, 2% ethyl acetate, 0.04% methionine, 4% Chinese medical concrete, 2% Chinese medicine ultra-fine powder, surplus is adjuvant;
Wherein, Chinese medical concrete is extracted respectively by following two groups of Chinese herbs to make:
A group is counted by weight: 20 parts of Herba Chlorophyti Comosi, 5 portions of Kalopanax septemlobums, 10 parts of Flos Lonicerae pampaininiis, 8 parts of Ramulus et Folium Pcrasmae (Cortex Picrasmae)s, 6 portions of Radix Glycyrrhizaes, 5 parts of Herba Lycopi, 9 portions of Radix Euryae Chinensis roots, 30 portions of Folium Eucalypti Robustae;
B group is counted by weight: 16 parts of Pilea lomatogramma Hand.-Mazz, 9 parts of Herba hibisci trionis, 7 parts of bar cling to flower, 30 parts of Strobilanthes sarcorrhizus Cling, 20 parts of Folium Broussonetiae, 3 parts of Herba Solani Lyratis, 6 parts of Dischidia minor (Vahl) Merr, 3 parts of green Bulbus Liliies, 12 portions of Radix Raphanis;
Wherein, Chinese medicine ultra-fine powder is counted by weight is be made up of following Chinese herb: 10 parts of Ramulus et Folium Psychotriae Serpentis, 12 portions of Radix Plumbaginis Zeylanicaes, 4 parts of Magnetite, 15 parts of Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendles, 6 parts of Umbillcaria esculentas, 20 parts of loose blood celerys, 16 parts of Herba potentillae fulgentis, 8 parts of swallow tails;
Wherein, adjuvant is counted by weight and is comprised: 5 parts of glycerol, 0.5 part of sodium alginate, 0.002 part of benzalkonium chloride, 0.02 part of tartaric acid, 0.001 part of cetylpyridinium chloride (CPC), 0.3 part of poloxamer188, borate buffer solution, 55 parts of waters for injection such as 2 parts.
Preservative benzalkonium chloride not only can be used as antiseptic and uses, and also plays the effect of sterilization in pharmaceutical composition of the present invention, and low concentration uses no skin irritation; Tartaric acid can prevent oxidation of drug from going bad as antioxidation reinforcing agent; Surfactant cetylpyridinium chloride (CPC) has good surface activity and sterilizing performance; Stabilizing agent poloxamer188 not only has Stabilization, can also increase the surface dissolution degree of multi-medicament, good with skin intermiscibility, increases cutaneous permeability, can promote the absorption of topical agent; Isoosmotic adjusting agent borate buffer solution makes osmotic pressure inside and outside skin keep balance, prevents wound surface Skin Cell serosity to run off.
This pharmaceutical composition preparation method being used for localized burn nursing is:
(1) Chinese medical concrete is prepared:
A group Chinese herb is taken: Herba Chlorophyti Comosi, Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Euryae Chinensis root, Radix Glycyrrhizae, Herba Lycopi, Folium Eucalypti Robustae, Kalopanax septemlobum, Flos Lonicerae pampaininii by described weight proportion, be crushed to 80 orders, merceration 1h, 2.5h is decocted with water by solid-to-liquid ratio 1: 14, after gained decoction liquor is filtered, concentrating under reduced pressure become relative density be 0.85 extractum, obtain extractum a;
B group Chinese herb is taken: Pilea lomatogramma Hand.-Mazz, Herba hibisci trioni, Ba Bahua, Strobilanthes sarcorrhizus Cling, Folium Broussonetiae, Herba Solani Lyrati, Dischidia minor (Vahl) Merr, green Bulbus Lilii, Radix Raphani by described weight proportion, with an organic solvent extract, extract is condensed into the extractum that relative density is 0.85, obtains extractum b; Described organic solvent be selected from methanol, ethanol, acetone, ethyl acetate, n-butyl alcohol, chloroform, dichloromethane any one.
Above-mentioned obtained extractum a and extractum b is merged, namely obtains described Chinese medical concrete;
(2) Chinese medicine ultra-fine powder is prepared:
Take Ramulus et Folium Psychotriae Serpentis, Radix Plumbaginis Zeylanicae, Magnetite, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle, Umbillcaria esculenta, loose blood celery, Herba potentillae fulgentis, swallow tail by described weight proportion, be first ground into coarse powder with pulverizer, then be placed in the micropowder that jet mill is ground into 1 μm, namely obtain described Chinese medicine ultra-fine powder;
(3) sodium alginate is dispersed in glycerol, the water for injection adding 1/3 dissolves, be stirred well to the solution forming homogenizing, add Chinese medical concrete, Chinese medicine nano powder, antiseptic, antioxidation reinforcing agent, surfactant, stabilizing agent, isoosmotic adjusting agent again, and remaining 2/3 water for injection, limit edged stirs, high pressure steam sterilization, subpackage, to obtain final product.
Embodiment 2:
A kind of pharmaceutical composition for localized burn nursing, comprise following component: 1.1% caffeic acid, 2% gentisic acid, 1.5% cupreol, 0.05% triclosan, 0.65% Palmic acid, 6% β-chitosan, 1.7% glutamic acid, 2.25% ethyl acetate, 0.07% methionine, 7% Chinese medical concrete, 3.5% Chinese medicine ultra-fine powder, also comprise the Adeps Felis domestica of 0.45%, surplus is adjuvant;
Wherein, Chinese medical concrete is extracted respectively by following two groups of Chinese herbs to make:
A group is counted by weight: 25 parts of Herba Chlorophyti Comosi, 7.5 portions of Kalopanax septemlobums, 16 parts of Flos Lonicerae pampaininiis, 14 parts of Ramulus et Folium Pcrasmae (Cortex Picrasmae)s, 10.5 portions of Radix Glycyrrhizaes, 10 parts of Herba Lycopi, 12 portions of Radix Euryae Chinensis roots, 37.5 portions of Folium Eucalypti Robustae;
B group is counted by weight: 23 parts of Pilea lomatogramma Hand.-Mazz, 12 parts of Herba hibisci trionis, 8.5 parts of bar cling to flower, 35 parts of Strobilanthes sarcorrhizus Cling, 32 parts of Folium Broussonetiae, 6.5 parts of Herba Solani Lyratis, 7.5 parts of Dischidia minor (Vahl) Merr, 4 parts of green Bulbus Liliies, 21 portions of Radix Raphanis;
Wherein, Chinese medicine ultra-fine powder is counted by weight is be made up of following Chinese herb: 12.5 parts of Ramulus et Folium Psychotriae Serpentis, 15 portions of Radix Plumbaginis Zeylanicaes, 5.5 parts of Magnetite, 22.5 parts of Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendles, 8 parts of Umbillcaria esculentas, 22.5 parts of loose blood celerys, 23 parts of Herba potentillae fulgentis, 11.5 parts of swallow tails;
Wherein, adjuvant is counted by weight and is comprised: 5 ~ 8 parts of glycerol, 1.0 parts of sodium alginates, 0.006 part of benzalkonium chloride, 0.035 part of tartaric acid, 0.008 part of Tween 80,0.65 part of poloxamer188, borate buffer solution, 67.5 parts of waters for injection such as 2.4 parts.
Preservative benzalkonium chloride not only can be used as antiseptic and uses, and also plays the effect of sterilization in pharmaceutical composition of the present invention, and low concentration uses no skin irritation; Tartaric acid can prevent oxidation of drug from going bad as antioxidation reinforcing agent; Surface active agent tween 80 belongs to nonionic surfactant, has good emulsification; Stabilizing agent poloxamer188 not only has Stabilization, can also increase the surface dissolution degree of multi-medicament, good with skin intermiscibility, increases cutaneous permeability, can promote the absorption of topical agent; Isoosmotic adjusting agent borate buffer solution makes osmotic pressure inside and outside skin keep balance, prevents wound surface Skin Cell serosity to run off.
This pharmaceutical composition preparation method being used for localized burn nursing is:
(1) Chinese medical concrete is prepared:
A group Chinese herb is taken: Herba Chlorophyti Comosi, Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Euryae Chinensis root, Radix Glycyrrhizae, Herba Lycopi, Folium Eucalypti Robustae, Kalopanax septemlobum, Flos Lonicerae pampaininii by described weight proportion, be crushed to 90 orders, merceration 1h, 3.0h is decocted with water by solid-to-liquid ratio 1: 17, after gained decoction liquor is filtered, concentrating under reduced pressure become relative density be 0.95 extractum, obtain extractum a;
B group Chinese herb is taken: Pilea lomatogramma Hand.-Mazz, Herba hibisci trioni, Ba Bahua, Strobilanthes sarcorrhizus Cling, Folium Broussonetiae, Herba Solani Lyrati, Dischidia minor (Vahl) Merr, green Bulbus Lilii, Radix Raphani by described weight proportion, with an organic solvent extract, extract is condensed into the extractum that relative density is 0.95, obtains extractum b; Described organic solvent be selected from methanol, ethanol, acetone, ethyl acetate, n-butyl alcohol, chloroform, dichloromethane any one.
Above-mentioned obtained extractum a and extractum b is merged, namely obtains described Chinese medical concrete;
(2) Chinese medicine ultra-fine powder is prepared:
Ramulus et Folium Psychotriae Serpentis, Radix Plumbaginis Zeylanicae, Magnetite, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle, Umbillcaria esculenta, loose blood celery, Herba potentillae fulgentis, swallow tail is taken by described weight proportion, first be ground into coarse powder with pulverizer, be placed in the micropowder that jet mill is ground into 25.5 μm again, namely obtain described Chinese medicine ultra-fine powder;
(3) sodium alginate is dispersed in the mixture of glycerol and Adeps Felis domestica, the water for injection adding 1/3 dissolves, be stirred well to the solution forming homogenizing, add Chinese medical concrete, Chinese medicine nano powder, antiseptic, antioxidation reinforcing agent, surfactant, stabilizing agent, isoosmotic adjusting agent again, and remaining 2/3 water for injection, limit edged stirs, high pressure steam sterilization, subpackage, to obtain final product.
Embodiment 3:
A kind of pharmaceutical composition for localized burn nursing, comprise following component: 2% caffeic acid, 3% gentisic acid, 2.5% cupreol, 0.06% triclosan, 1.0% Palmic acid, 7% β-chitosan, 2.4% glutamic acid, 2.5% ethyl acetate, 0.1% methionine, 10% Chinese medical concrete, 5% Chinese medicine ultra-fine powder, also comprise the Adeps Felis domestica of 0.6%, surplus is adjuvant;
Wherein, Chinese medical concrete is extracted respectively by following two groups of Chinese herbs to make:
A group is counted by weight: 30 parts of Herba Chlorophyti Comosi, 10 portions of Kalopanax septemlobums, 22 parts of Flos Lonicerae pampaininiis, 20 parts of Ramulus et Folium Pcrasmae (Cortex Picrasmae)s, 15 portions of Radix Glycyrrhizaes, 15 parts of Herba Lycopi, 15 portions of Radix Euryae Chinensis roots, 45 portions of Folium Eucalypti Robustae;
B group is counted by weight: 30 parts of Pilea lomatogramma Hand.-Mazz, 15 parts of Herba hibisci trionis, 10 parts of bar cling to flower, 40 parts of Strobilanthes sarcorrhizus Cling, 44 parts of Folium Broussonetiae, 10 parts of Herba Solani Lyratis, 9 parts of Dischidia minor (Vahl) Merr, 5 parts of green Bulbus Liliies, 30 portions of Radix Raphanis;
Wherein, Chinese medicine ultra-fine powder is counted by weight is be made up of following Chinese herb: 15 parts of Ramulus et Folium Psychotriae Serpentis, 18 portions of Radix Plumbaginis Zeylanicaes, 7 parts of Magnetite, 30 parts of Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendles, 10 parts of Umbillcaria esculentas, 25 parts of loose blood celerys, 30 parts of Herba potentillae fulgentis, 15 parts of swallow tails;
Wherein, adjuvant is counted by weight and is comprised: 8 parts of glycerol, 1.5 parts of sodium alginates, 0.01 part of benzylalcohol, 0.05 part of tartaric acid, 0.015 part of cetylpyridinium chloride (CPC), 1.0 parts of poloxamer188s, borate buffer solution, 80 parts of waters for injection such as 2.8 parts.
Benzylalcohol can play good antisepsis as antiseptic, and tartaric acid can prevent oxidation of drug from going bad as antioxidation reinforcing agent; Surfactant is selected from cetylpyridinium chloride (CPC) and has good surface activity and sterilizing performance; Stabilizing agent poloxamer188 not only has Stabilization, can also increase the surface dissolution degree of multi-medicament, good with skin intermiscibility, increases cutaneous permeability, can promote the absorption of topical agent; Isoosmotic adjusting agent borate buffer solution makes osmotic pressure inside and outside skin keep balance, prevents wound surface Skin Cell serosity to run off.
This pharmaceutical composition preparation method being used for localized burn nursing is:
(1) Chinese medical concrete is prepared:
A group Chinese herb is taken: Herba Chlorophyti Comosi, Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Euryae Chinensis root, Radix Glycyrrhizae, Herba Lycopi, Folium Eucalypti Robustae, Kalopanax septemlobum, Flos Lonicerae pampaininii by described weight proportion, be crushed to 100 orders, merceration 1h, 3.5h is decocted with water by solid-to-liquid ratio 1: 20, after gained decoction liquor is filtered, concentrating under reduced pressure become relative density be 1.05 extractum, obtain extractum a;
B group Chinese herb is taken: Pilea lomatogramma Hand.-Mazz, Herba hibisci trioni, Ba Bahua, Strobilanthes sarcorrhizus Cling, Folium Broussonetiae, Herba Solani Lyrati, Dischidia minor (Vahl) Merr, green Bulbus Lilii, Radix Raphani by described weight proportion, with an organic solvent extract, extract is condensed into the extractum that relative density is 1.05, obtains extractum b; Described organic solvent be selected from methanol, ethanol, acetone, ethyl acetate, n-butyl alcohol, chloroform, dichloromethane any one.
Above-mentioned obtained extractum a and extractum b is merged, namely obtains described Chinese medical concrete;
(2) Chinese medicine ultra-fine powder is prepared:
Take Ramulus et Folium Psychotriae Serpentis, Radix Plumbaginis Zeylanicae, Magnetite, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle, Umbillcaria esculenta, loose blood celery, Herba potentillae fulgentis, swallow tail by described weight proportion, be first ground into coarse powder with pulverizer, then be placed in the micropowder that jet mill is ground into 50 μm, namely obtain described Chinese medicine ultra-fine powder;
(3) sodium alginate is dispersed in the mixture of glycerol and Adeps Felis domestica, the water for injection adding 1/3 dissolves, be stirred well to the solution forming homogenizing, add Chinese medical concrete, Chinese medicine nano powder, antiseptic, antioxidation reinforcing agent, surfactant, stabilizing agent, isoosmotic adjusting agent again, and remaining 2/3 water for injection, limit edged stirs, high pressure steam sterilization, subpackage, to obtain final product.
Clinical practice:
Case 1: grandson, man, 41 years old, arm is burnt, and wound surface causes infection owing to not obtaining process in time, has faint yellow thick secretions, pus or abscess is there is under crust, be burn infection after diagnosing, through using localized burn nursing agent compositions of the present invention after 2 days, secretions disappears, after 4 days, abscess disappears, and after 6 days, wound heals substantially.
Case 2: Wang, man, 12 years old, skin of back is scalded serious, causes and infects, and form a scab during treatment, have the pus of green sweet fishy taste under crust, deep-level blood vessel is downright bad, and wound delays to heal, through using localized burn nursing agent compositions of the present invention after 3 days, green secretions disappears, and crust starts to come off, after 5 days, internal layer skin starts to restore gradually, and after 2 weeks, wound heals substantially.
Case 3: defend certain, man, 23 years old,, there is red and swollen, petechia around wound surface, crust have grey white dirt in instep large-area burns, on wound surface, present the thin powder of one deck after several days, there is erosion in part, is burn infection after diagnosing, through using localized burn nursing agent compositions of the present invention after 2 days, red and swollen disappearance around wound surface, after 3 days, thin powder disappears, after 1 week, wound heals substantially.
Case 4: poplar, female, 7 years old, arm is burnt, granulation tissue edema, and part is downright bad, after diagnosing for infection of staphylococcus aureus causes, make burn treating effect slow, through using localized burn nursing agent compositions of the present invention after 3 days, granulation tissue edematous condition disappears, after 7 days, slough comes off, and after 2 weeks, wound heals substantially.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (9)
1. the pharmaceutical composition for localized burn nursing, it is characterized in that, comprise following component: 0.2 ~ 2% caffeic acid, 1 ~ 3% gentisic acid, 0.5 ~ 2.5% cupreol, 0.04 ~ 0.06% triclosan, 0.3 ~ 1.0% Palmic acid, 5 ~ 7% β-chitosan, 1 ~ 2.4% glutamic acid, 2 ~ 2.5% ethyl acetate, 0.04 ~ 0.1% methionine, 4 ~ 10% Chinese medical concretes, 2 ~ 5% Chinese medicine ultra-fine powders, surplus is adjuvant;
Described Chinese medical concrete is extracted respectively by following two groups of Chinese herbs to make:
A group is counted by weight: 20 ~ 30 parts of Herba Chlorophyti Comosi, 5 ~ 10 portions of Kalopanax septemlobums, 10 ~ 22 parts of Flos Lonicerae pampaininiis, 8 ~ 20 parts of Ramulus et Folium Pcrasmae (Cortex Picrasmae)s, 6 ~ 15 portions of Radix Glycyrrhizaes, 5 ~ 15 parts of Herba Lycopi, 9 ~ 15 portions of Radix Euryae Chinensis roots, 30 ~ 45 portions of Folium Eucalypti Robustae;
B group is counted by weight: 16 ~ 30 parts of Pilea lomatogramma Hand.-Mazz, 9 ~ 15 parts of Herba hibisci trionis, 7 ~ 10 parts of bar cling to flower, 30 ~ 40 parts of Strobilanthes sarcorrhizus Cling, 20 ~ 44 parts of Folium Broussonetiae, 3 ~ 10 parts of Herba Solani Lyratis, 6 ~ 9 parts of Dischidia minor (Vahl) Merr, 3 ~ 5 parts of green Bulbus Liliies, 12 ~ 30 portions of Radix Raphanis;
It is be made up of following Chinese herb that described Chinese medicine ultra-fine powder is counted by weight: 10 ~ 15 parts of Ramulus et Folium Psychotriae Serpentis, 12 ~ 18 portions of Radix Plumbaginis Zeylanicaes, 4 ~ 7 parts of Magnetite, 15 ~ 30 parts of Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendles, 6 ~ 10 parts of Umbillcaria esculentas, 20 ~ 25 parts of loose blood celerys, 16 ~ 30 parts of Herba potentillae fulgentis, 8 ~ 15 parts of swallow tails;
Described adjuvant is counted by weight and is comprised: 5 ~ 8 parts of glycerol, 0.5 ~ 1.5 part of sodium alginate, 0.002 ~ 0.01 portion of antiseptic, 0.02 ~ 0.05 part of antioxidation reinforcing agent, 0.001 ~ 0.015 part of surfactant, 0.3 ~ 1.0 part of stabilizing agent, 2 ~ 2.8 parts of isoosmotic adjusting agent, 55 ~ 80 parts of waters for injection.
2. as claimed in claim 1 a kind of for localized burn nursing pharmaceutical composition, it is characterized in that, described antiseptic is benzalkonium chloride or benzylalcohol.
3. as claimed in claim 1 a kind of for localized burn nursing pharmaceutical composition, it is characterized in that, described antioxidation reinforcing agent is tartaric acid.
4. as claimed in claim 1 a kind of for localized burn nursing pharmaceutical composition, it is characterized in that, described surfactant is selected from cetylpyridinium chloride (CPC) or Tween 80.
5. as claimed in claim 1 a kind of for localized burn nursing pharmaceutical composition, it is characterized in that, described stabilizing agent is poloxamer188.
6. as claimed in claim 1 a kind of for localized burn nursing pharmaceutical composition, it is characterized in that, described isoosmotic adjusting agent is borate buffer solution.
7. as claimed in claim 1 a kind of for localized burn nursing pharmaceutical composition, it is characterized in that, under preparation method enters:
(1) Chinese medical concrete is prepared:
A group Chinese herb is taken: Herba Chlorophyti Comosi, Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Euryae Chinensis root, Radix Glycyrrhizae, Herba Lycopi, Folium Eucalypti Robustae, Kalopanax septemlobum, Flos Lonicerae pampaininii by described weight proportion, be crushed to 80 ~ 100 orders, merceration 1h, 2.5 ~ 3.5h is decocted with water by solid-to-liquid ratio 1: 14 ~ 20, after gained decoction liquor is filtered, concentrating under reduced pressure become relative density be 0.85 ~ 1.05 extractum, obtain extractum a;
B group Chinese herb is taken: Pilea lomatogramma Hand.-Mazz, Herba hibisci trioni, Ba Bahua, Strobilanthes sarcorrhizus Cling, Folium Broussonetiae, Herba Solani Lyrati, Dischidia minor (Vahl) Merr, green Bulbus Lilii, Radix Raphani by described weight proportion, with an organic solvent extract, extract is condensed into the extractum that relative density is 0.85 ~ 1.05, obtains extractum b;
Above-mentioned obtained extractum a and extractum b is merged, namely obtains described Chinese medical concrete;
(2) Chinese medicine ultra-fine powder is prepared:
Ramulus et Folium Psychotriae Serpentis, Radix Plumbaginis Zeylanicae, Magnetite, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle, Umbillcaria esculenta, loose blood celery, Herba potentillae fulgentis, swallow tail is taken by described weight proportion, first be ground into coarse powder with pulverizer, be placed in the micropowder that jet mill is ground into 1 ~ 50 μm again, namely obtain described Chinese medicine ultra-fine powder;
(3) sodium alginate is dispersed in glycerol, the water for injection adding 1/3 dissolves, be stirred well to the solution forming homogenizing, add Chinese medical concrete, Chinese medicine nano powder, antiseptic, antioxidation reinforcing agent, surfactant, stabilizing agent, isoosmotic adjusting agent again, and remaining 2/3 water for injection, limit edged stirs, sterilizing, subpackage, to obtain final product.
8. as claimed in claim 7 a kind of for localized burn nursing pharmaceutical composition, it is characterized in that, the organic solvent in described step (1) be selected from methanol, ethanol, acetone, ethyl acetate, n-butyl alcohol, chloroform, dichloromethane any one.
9. as claimed in claim 7 a kind of for localized burn nursing pharmaceutical composition, it is characterized in that, the sterilizing methods in described step (3) is high pressure steam sterilization.
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| CN106913866A (en) * | 2015-12-26 | 2017-07-04 | 重庆市康泽科技开发有限责任公司 | Black hair Chinese medicine composition |
| CN116942696A (en) * | 2023-08-07 | 2023-10-27 | 陕西科技大学 | Application of ferrous ions in preparation of scald infection treatment medicines and scald nursing products |
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