CN105160152A - Safe operation method for artificial fertilization, in-vitro fertilization and embryo transfer - Google Patents
Safe operation method for artificial fertilization, in-vitro fertilization and embryo transfer Download PDFInfo
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- CN105160152A CN105160152A CN201510467922.8A CN201510467922A CN105160152A CN 105160152 A CN105160152 A CN 105160152A CN 201510467922 A CN201510467922 A CN 201510467922A CN 105160152 A CN105160152 A CN 105160152A
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Abstract
A safe recording and comparison method for artificial fertilization, in-vitro fertilization and embryo transfer comprises the following steps of: step 1, archiving of a male parent and a female parent: storing identity information, pairing information and biological feature information; step 2, semen collection: identifying male parent information at first, then collecting semen, and establishing a matching relation between the semen and the male parent; step 3, semen treatment: during treatment, checking whether the semen is matched with the male parent in each sample transfer or transmitting the matching relation; step 4, ovum collection: identifying female parent information at first, then collecting an ovum, and establishing a matching relation between the ovum and the female parent; step 5, ovum fertilization: identifying semen and ovum information at first, then checking whether pairing is allowed, and if so, continuing, or otherwise, sending out an error prompt; and step 6, transplantation: verifying the female parent information at first, then checking whether an embryo is matched with the female parent, and if so, continuing, or otherwise, sending out the error prompt. The checking is performed before every operation to prevent errors.
Description
Technical field
The present invention relates to medical field, be specifically related to the safety record control methods of a kind of artificial insemination, extracorporeal fertilizating and embryo transplanting.
Background technology
(InVitroFertilization) in vitro fertilization or (externalfertilization) refer to that mammiferous sperm and ovum complete the technology of fertilization process in vitro in manually operated environment, and English abbreviation is IVF.Because it is inseparable with embryo transfer technology (ET), again referred to as IVF-ET.In biology, claim test-tube animal (test-tubeanimal) the animal obtained after IVF to parent.The success of this technology, the 1950's, development in nearest 20 years rapidly, now reaches its maturity and becomes that one important and the animal reproduction biotechnology of routine is drawn.Need to carry out getting essence respectively due in the process of being fertilized in vitro, get ovum, sperm ovum binding and implant the steps such as parent, operation link is various, traditional dependence is manually differentiated, is checked, extremely easily there is mistake, any one link makes a mistake all can cause extremely serious consequence---and light then medical tangle occurs, heavy then cause serious ethics problem.
Chinese patent CN103942303A discloses a kind of in vitro fertilization and embryo transfer information checking method, and its method is as follows: A1, be stored in database by corresponding to sperm, ovum, embryo and parent identity information; A2, to be identified by radio-frequency technique and be currently loaded with sperm, ovum, the double dish of embryo and the related identification information of parent identification ring; A3, search database, whether the identity information that comparison obtains mates with database, and if so, then pairing is correct; If not, then mistake is matched.The method can when not needing manual intervention, sperm, ovum, the double dish of embryo and the identity information of parent identification ring is loaded with when distinguishing out in vitro fertilization and embryo transfer by REID, and compared by the identity information distinguished, thus ensure that accuracy that is in vitro fertilization and embryo transfer.
But there is following problem in the method in practical operation:
(1) only there is parent identification ring identification parent information, fail to identify male parent's information
(2) identification ring recording parent identity information easily leaves behind, cannot comparison situation when causing use; Identification ring may be damaged or lose, and causes the event of data loss of storage; Identification ring will match with individuality before use, if there occurs human error in pairing process, causes follow-up all operations all can mistake; Identification ring is easily obscured between individuals, and particularly application scenarios is if the situation of mistake easily occurs to wear mutually the individuality that individuality thick and fast, flocks together, and this also can cause follow-up all operations all can mistake.
(3) the method identify at every turn current be loaded with sperm, ovum, the double dish of embryo and the related identification information of parent identification ring after, search the database identity information that only comparison obtains and whether mate with database.
(4) the method only contain sperm ovum binding preoperative check with embryo transfer before check, and do not comprise checking in liquefacient duration process, the sperm being likely mixed into other male parent causes sample to obscure or pollutes, and does not also comprise checking before artificial insemination.
(5) the method does not record all operations procedural information in a database, cannot review when there is erroneous results.
Summary of the invention
For solving the problems of the technologies described above, the object of the present invention is to provide the method for artificial insemination that a kind of safety is detailed, in vitro fertilization and embryo transfer, to solve the contingent problem that may exist in existing in vitro fertilization and embryo transfer process.
For achieving the above object, the safety record control methods of a kind of in vitro fertilization and embryo transfer that the present invention proposes, it is characterized in that: described extracorporeal fertilizating and embryo transplanting method comprises the following steps,
Step1. male parent female parent is filed, the respective identity information of male parent female parent, unpaired message and biological information are stored in computing machine;
Step2. get essence, first identify male parent information, then carry out getting essence, set up the matching relationship of this semen sample and male parent;
Step3. liquefacient duration, seminal fluid processes in different vessel, transfer, all reads sample information before and after each transfer, matching relationship can be delivered to new vessel with seminal fluid transfer, also whether can check the seminal fluid that is equipped with in multiple vessel from same male parent, be not send rub-out signal;
Step4. get ovum, first identify maternal information, then carry out getting ovum, picking up ovum, set up this ovum sample and maternal matching relationship;
Whether Step5. ovum fertilization, first reads semen sample and ovum sample information, then checking maternal from allowing the male parent of pairing, allowing pairing then to carry out ovum fertilization, being then cultured to embryo, not allowing pairing then to send rub-out signal;
Whether Step6. transplant, first verify maternal information, then check embryo and mate with female parent, coupling is then transplanted, and does not mate, sends rub-out signal.
A kind of artificial insemination method that the present invention proposes, is characterized in that: described artificial insemination method comprises the following steps,
Step1. male parent female parent is filed, the respective identity information of male parent female parent, unpaired message and biological information are stored in computing machine;
Step2. get essence, first identify male parent information, then carry out getting essence, set up the matching relationship of this semen sample and male parent;
Step3. liquefacient duration, seminal fluid processes in different vessel, transfer, all reads sample information before and after each transfer, matching relationship can be delivered to new vessel with seminal fluid transfer, also whether can check the seminal fluid that is equipped with in multiple vessel from same male parent, be not send rub-out signal;
Whether Step4. artificial insemination, first verifies maternal information, then check semen sample and allow to mate with female parent, allows coupling then to carry out artificial insemination, does not allow coupling then to send rub-out signal.
Further, described in operate in enforcement before carry out the maternal information identification of male parent and specimen discerning, set up matching relationship by computing machine or check matching relationship by computer search.If check correct, next step operation can be carried out; If to checking mistake, then send rub-out signal, described rub-out signal can adopt screen flicker, blue light, audio warning or many persons to combine.After sending rub-out signal, artificial releasing just can carry out next step.
Further, described identity information can be one or more in personalized identity documents, person identifier card, social information's card etc., and biological characteristic is one or more in fingerprint, iris, palmmprint, skin, face or vein pattern etc.
Further, the described vessel that sample is housed or vessel attachment are provided with the electronic tag be made up of chip and coil.With positions such as the incubators depositing sample, the electronic tag recognition device be connected with computing machine is installed at operator's console.
Further, at the maternal identified region of male parent, the identity recognition device and biometric devices that are connected with computing machine are installed.
Further, when operating at every turn, computing machine carries out record store the maternal information of corresponding male parent, sample information, associative operation information.
Further, described electronic tag recognition device has multi-face solid induction antenna, ensures that the electronic tag of different angles in induction region can be identified, and establishes the thermostat of temp. controllable in device simultaneously, ensures sample biologically active.
The present invention compared with prior art, its beneficial effect is: a kind of artificial insemination that the present invention proposes, the safety record control methods of in vitro fertilization and embryo transfer, the personally identifiable information of male parent female parent, unpaired message and biological characteristic are carried out storage of filing, and then carry out getting essence, liquefacient duration, get ovum, ovum fertilization, embryo transfer, the operation such as artificial insemination, before operation each time, all carry out there is independently checking step, prevent artificial misoperation; Check and can utilize male parent or itself biological characteristic comparison maternal, such as fingerprint or iris recognition, be not only rely on identification ring, can not obscure, lose, damage, leave behind that cause cannot the situation of comparison or comparison mistake; Electronic tag recognition device has multi-face solid induction antenna, ensure the electronic tag of different angles in induction region, multiple electronic tag can identify simultaneously, the thermostat of temp. controllable is installed in electronic tag recognition device, temperature needed for sample survival can be provided when identifying or operate sample, ensure biologically active; Often all have recorded the information such as operand information, operator, running time, operating position operated at that time during step operation, review for process and data are provided.
Accompanying drawing explanation
Fig. 1 is extracorporeal fertilizating and embryo transplanting schematic flow sheet of the present invention;
Fig. 2 is artificial insemination schematic flow sheet of the present invention.
Embodiment
By describe in detail the present invention technology contents, structural attitude, reached object and effect, hereby exemplify embodiment below and coordinate accompanying drawing to be explained in detail.
Refer to shown in Fig. 1, the invention provides a kind of safety record control methods of in vitro fertilization and embryo transfer, described method comprises the following steps:
Step1. male parent female parent is filed, in the database of computing machine, record the information (in personalized identity documents, person identifier card, Intelligent bracelet information one or more) of male parent female parent and its respective biological attribute data (in fingerprint, iris, palmmprint, skin, face or vein pattern one or more); The unpaired message of record male parent female parent.
Step2. essence is got, first by identifying that the biological information (such as contrasting fingerprint) of male parent identifies individual information, then the smart cup with electronic tag is utilized to get essence, the electronic tag recognition device that multi-face solid induction antenna is housed by inside reads electronic labeling information on smart cup, sets up the matching relationship of male parent and this sample in a database;
Step3. liquefacient duration, in processing procedure, seminal fluid shifts in the vessel such as smart cup and multiple centrifuge tubes, each vessel are with electronic tag, electronic tag recognition device is utilized to read multiple sample information before and after each transfer, check whether all come from same male parent by computing machine, if next step operation then can be carried out, if not then give the alarm.In processing procedure, if electronic tag recognition device reads untapped pocket ware, give the alarm.If need pocket ware to distribute to this sample to use, the matching relationship of male parent and these vessel can be set up in a database; More than operation can ensure can not to occur in whole liquefacient duration and transfer process the situation that different semen sample is obscured, mistaken;
Step4. ovum is got, first by identifying that maternal biological information (such as contrasting fingerprint) identifies individual information, to take after ovum in the process of picking up ovum, ovum is put into the vessel being provided with electronic tag, read vessel by electronic tag recognition device to power on subtab information, set up matching relationship that is maternal and this sample in a database;
Step5. ovum fertilization, first utilize electronic tag recognition device to read sample information, then whether carried out the male parent female parent of Self Matching by computer search sperm and ovum, after confirmation, carry out ovum fertilization again, do not mate, give the alarm, the ovum of after fertilization continues to be cultured to embryo or blastaea; The constant temperature heating device that can ensure that sample is survived is provided with in this operator's console;
Step6. first first identify whether the biological information (such as contrasting fingerprint) of parent to be transplanted mates with the maternal information of database before transplanting, then the embryo utilizing electronic tag recognition device identification to be transplanted or blastaea information, check this information by computer search whether to mate with female parent, if whole coupling, can transplant.
For artificial insemination, first three step is the same with external fertilization method, first identified before carrying out artificial insemination and treat whether the biological information (such as contrasting fingerprint) of test-tube parent mates with the maternal information of database, then electronic tag recognition device identification is utilized to prepare the semen sample information injected, check this information by computer search whether to mate with female parent, if coupling, can carry out artificial insemination, not mate, give the alarm.
Each walks operating process, and computing machine all can carry out record to the nodal information such as information, operator, running time, operating position of operation sample and store, and is convenient to review for later process provide detailed data.
In sum, be only the preferred embodiment of the present invention, do not limit protection scope of the present invention with this, all equivalence changes done according to the scope of the claims of the present invention and description with modify, be all within scope that patent of the present invention contains.
Claims (8)
1. a method for safely carrying out for artificial insemination, extracorporeal fertilizating and embryo transplanting, is characterized in that: described extracorporeal fertilizating and embryo transplanting method comprises the following steps:
Step1. male parent female parent is filed, maternal for male parent respective identity information, unpaired message and biological information is stored in computing machine;
Step2. get essence, first identify male parent information, then carry out getting essence, set up the matching relationship of this semen sample and male parent;
Step3. liquefacient duration, seminal fluid processes in different vessel, transfer, all reads sample information before and after each transfer, matching relationship can be delivered to new vessel with seminal fluid transfer, also whether can check the seminal fluid that is equipped with in multiple vessel from same male parent, be not send rub-out signal;
Step4. get ovum, first identify maternal information, then carry out getting ovum, picking up ovum, set up this ovum sample and maternal matching relationship;
Whether Step5. ovum fertilization, first reads semen sample and ovum sample information, then checking maternal from allowing the male parent of pairing, allowing pairing then to carry out ovum fertilization, being then cultured to embryo, not allowing pairing then to send rub-out signal;
Whether Step6. transplant, first verify maternal information, then check embryo and mate with female parent, coupling is then transplanted, and does not mate, sends rub-out signal.
2. the method for safely carrying out of a kind of artificial insemination according to claim 1, extracorporeal fertilizating and embryo transplanting, is characterized in that: described artificial insemination method comprises the following steps:
Step1. male parent female parent is filed, the respective identity information of male parent female parent, unpaired message and biological information are stored in computing machine;
Step2. get essence, first identify male parent information, then carry out getting essence, set up the matching relationship of this semen sample and male parent;
Step3. liquefacient duration, seminal fluid processes in different vessel, transfer, all reads sample information before and after each transfer, matching relationship can be delivered to new vessel with seminal fluid transfer, also whether can check the seminal fluid that is equipped with in multiple vessel from same male parent, be not send rub-out signal;
Whether Step4. artificial insemination, first verifies maternal information, then check semen sample and allow to mate with female parent, allows coupling then to carry out artificial insemination, does not allow coupling then to send rub-out signal.
3. a kind of artificial insemination according to claim 1,2, the method for safely carrying out of extracorporeal fertilizating and embryo transplanting, it is characterized in that: described in operate in enforcement before carry out the maternal information identification of male parent and specimen discerning, set up matching relationship by computing machine or check matching relationship by computer search, if check correct, next step operation can be carried out; If to checking mistake, then send rub-out signal, described rub-out signal can adopt screen flicker, blue light, audio warning or many persons to combine, and after sending rub-out signal, artificial releasing just can carry out next step.
4. a kind of artificial insemination according to claim 1,2, the method for safely carrying out of extracorporeal fertilizating and embryo transplanting, it is characterized in that: described identity information can be one or more in personalized identity documents, person identifier card, social information's card etc., and biological characteristic is one or more in fingerprint, iris, palmmprint, skin, face or vein pattern etc.
5. a kind of artificial insemination according to claim 1,2, the method for safely carrying out of extracorporeal fertilizating and embryo transplanting, it is characterized in that: the described vessel that sample is housed or vessel attachment are provided with the electronic tag be made up of chip and coil, with positions such as the incubators depositing sample, the electronic tag recognition device be connected with computing machine is installed at operator's console.
6. a kind of artificial insemination according to claim 1,2, the method for safely carrying out of extracorporeal fertilizating and embryo transplanting, is characterized in that: be provided with at the maternal identified region of male parent the identity recognition device and biometric devices that are connected with computing machine.
7. a kind of artificial insemination according to claim 1,2, the method for safely carrying out of extracorporeal fertilizating and embryo transplanting, it is characterized in that: when operating at every turn, computing machine carries out record store the maternal information of corresponding male parent, sample information, associative operation information.
8. the method for safely carrying out of a kind of artificial insemination according to claim 5, extracorporeal fertilizating and embryo transplanting, is characterized in that: described electronic tag recognition device has multi-face solid induction antenna, establishes the thermostat of temp. controllable in device simultaneously.
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| CN111258089A (en) * | 2020-03-13 | 2020-06-09 | 宁夏医科大学总医院 | Be used for external fertilization-embryo transfer laboratory technical personnel operation system of rechecking |
| CN109207361B (en) * | 2018-09-21 | 2024-05-17 | 余裕炉 | Multifunctional integrated IVF workstation |
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| CN109952578A (en) * | 2016-09-13 | 2019-06-28 | 株式会社７７Ｋｃ | Individual management system |
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| CN109207361A (en) * | 2018-09-21 | 2019-01-15 | 余裕炉 | A kind of IVF work station of multifunctional unit |
| CN109207361B (en) * | 2018-09-21 | 2024-05-17 | 余裕炉 | Multifunctional integrated IVF workstation |
| CN109934598A (en) * | 2019-03-07 | 2019-06-25 | 重庆市千将软件有限公司 | Block chain tobacco traceability anti-fake system |
| CN109934598B (en) * | 2019-03-07 | 2023-10-27 | 重庆市千将软件有限公司 | Block chain tobacco traceability anti-counterfeiting system |
| CN110148446A (en) * | 2019-05-21 | 2019-08-20 | 重庆市柏玮熠科技有限公司 | IVF sample check system |
| CN111258089A (en) * | 2020-03-13 | 2020-06-09 | 宁夏医科大学总医院 | Be used for external fertilization-embryo transfer laboratory technical personnel operation system of rechecking |
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Application publication date: 20151216 |