CN105054972A - Ultrasound diagnosis and treatment system and method for treating tumour by adopting same - Google Patents
Ultrasound diagnosis and treatment system and method for treating tumour by adopting same Download PDFInfo
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- CN105054972A CN105054972A CN201510428803.1A CN201510428803A CN105054972A CN 105054972 A CN105054972 A CN 105054972A CN 201510428803 A CN201510428803 A CN 201510428803A CN 105054972 A CN105054972 A CN 105054972A
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Abstract
The invention discloses an ultrasound diagnosis and treatment system which comprises a master control center, an ultrasonic generator, a diagnosis and treatment integrated probe system and a signal processing center that are connected in sequence, wherein the diagnosis and treatment integrated probe system comprises an ultrasound triggering transducer and an ultrasonic imaging transducer which work in turns without interferences on each other, one end of the signal processing center is connected with the probe, while the other end of the signal processing center is connected with the master control center, the master control center controls the ultrasonic generator to emit ultrasonic waves, the ultrasonic waves are input to the probe through the ultrasound triggering transducer or the ultrasonic imaging transducer, the signals detected by the probe can return to the signal processing center for processing, and then the processed signals are fed back to the master control center. The invention further discloses a method for treating tumour by adopting the ultrasound diagnosis and treatment system. Compared with the prior art, the ultrasound diagnosis and treatment system realizes integration of ultrasound monitoring imaging and treatment and is widely applied to various ultrasound diagnosis and treatment methods, and the method for treating tumour by adopting ultrasound is greatly optimized.
Description
Technical field
The present invention relates to a kind of ultrasonic medical system, and utilize the method for this systematic treating tumor, belong to ultrasonic medical field.
Background technology
The M & M of tumor remains high, and traditional Therapeutic Method comprises operation, and radiation and chemotherapy etc. have the Therapeutic Method of wound.But operation cannot eradicate various carcinogenic factor, also tumor cell cannot be removed completely, though operation excised main portions, can metastasis may almost be present in each cancer patient.Meanwhile, excision by patient's state of an illness, body constitution, outside the impact of whether metastasis, also by surgical condition, environment, the impact of the factors such as the treatment level of doctor.The limitation of roentgenotherapia is that ray is large to human normal tissue damage, and it is limited that patient accepts actinotherapeutic dosage, can not accept radiotherapy for a long time.Although this Therapeutic Method of chemotherapy can destroy some tumor cell, but affecting larger is normal tissue cell, especially the normal immune function depression of body is the most serious, and the hemopoietic system infringement of chemotherapy on human body clearly, limits chemotherapeutics extensive use clinically.
Utilize ultrasonic therapeutic tumor, there is safety, side effect little and curative effect advantage rapidly, the especially introducing of acoustic contrast agent microbubble, expanded the lower targeting level diagnosis of ultrasonic field regulation and control and treatment function.But will realize the accurate Targeted-control of microbubble, the ultrasound wave requiring ultrasonic probe to launch is concentration ultrasonic, and its frequency, the sound intensity need be applicable to ultrasonic triggering microbubble and play a role.
Ultrasonic-B probe imaging has the following advantages: 1. show good to focus and surrounding tissue, can guide accurate location; 2. to patient and the radiationless damage of operator, can seriality monitor; 3. before and after can reflecting tumor focus treatment, blood is for change, improves the reliability of therapeutic evaluation.But there is certain uncertainty at present with the echo Estimating curative effect of B ultrasonic image, because at focal spot place because cavitation or tissue fluid boiling may contain little " hole " and " encapsulation of implosion ", the B ultrasonic image at such focal spot place can produce speck because echo is comparatively strong in the position of correspondence, after the regular hour, the echo that focal spot region produces can weaken gradually, and the speck in B ultrasonic image also fades away; 4. ultrasonic image change can reflect the change of focal zone preferably.As can be seen here, ultrasonic with it accurately, the feature such as reliable, practical, economic, convenient will become the main method of monitoring and therapeutic evaluation in real time.
Summary of the invention
Goal of the invention: the invention provides a kind of ultrasonic medical system and utilize the method for this systematic treating tumor, described ultrasonic medical system can complete the overall process of image supervisory control and treatment; And this system is not only applicable to utilize thermal effect of ultrasound controlled release to carry the temperature sensitive ultrasonic microbubble contrast of gene or medicine, is also applicable to microbubble contrast and blocks tumor vessel, the Diagnosis and Treat of tumor disease can be widely used in.
Technical scheme: in order to realize foregoing invention object, the invention discloses a kind of ultrasonic medical system, comprise be connected successively main control centre, supersonic generator, diagnosis and treatment integrated probe system and signal processing center;
Described probe system comprises can rotation work and the ultrasonic triggered transducer be independent of each other and ultra sonic imaging transducer; One end, described signal processing center is connected with probe, and one end is connected with main control centre;
Described main control centre controls supersonic generator and launches ultrasound wave, through ultrasonic triggered transducer or ultra sonic imaging transducer input probe; The signal of probe detection can turn back to signal processing center, after this is by signal processing, feed back to main control centre.
As preferably, described ultrasonic triggered transducer, ultra sonic imaging transducer linear array structure, their one end is connected with supersonic generator, and the other end is connected with probe;
Preferred as another kind, described ultra sonic imaging transducer is arranged on the centre of two ultrasonic triggered transducer, and by the angle between the ultrasonic triggered transducer of adjustment and ultra sonic imaging transducer and distance, ensure that the focal regions that ultrasonic triggered transducer produces drops in the video picture visual field of ultra sonic imaging transducer.
Preferred as another kind, the technical parameter of described ultrasonic triggered transducer is as follows:
Transducer length 20 ~ 60mm, wide 0.5 ~ 1.2cm; Array number: 128 array elements; Array element distance 0.1 ~ 0.6mm; Focal length: 2 ~ 6cm; Transducer operating frequency: 0.8 ~ 1.2MHz; Focal shape: elliposoidal; The focal regions center sound intensity: 0.5 ~ 2.5W/cm
2, acoustic pressure: 120 ~ 300Kpa.
The technical parameter of ultra sonic imaging transducer is as follows:
Array number: 128 array elements; Transducer operating frequency: 5 ~ 10MHz; Investigation depth :≤6cm; The sound intensity (I
sPTA): 0.01 ~ 0.03W/cm
2.
The invention provides the method utilizing above-mentioned ultrasonic medical systematic treating tumor, comprise the steps:
(1) detect: main control centre controls ultra sonic imaging transducer and launches ultrasonic by probe to knub position, imaging is carried out to detecting location, and the position injection microbubble contrast determined, by fixed point radiation, utilize the effect of ultrasonic radiation force, the fixed point realizing microbubble contrast is assembled.And then, signal is turned back to signal processing center, recognize to find target tumor tissue to image, also referred to as target area, calculate original gray value;
(2) treat: main control centre controls ultrasonic triggered transducer and launches focus supersonic by probe to target area, because the energy of focus supersonic is higher, to the microbubble heating assembled, microbubble is expanded; Or make temperature sensitive microbubble release tumor medicine or the gene after thermal effect of ultrasound assembled; Final blocking-up tumor neogenetic blood vessels or improve the absorption of tumor tissues to medicine and gene, reaches the object of neoplasm targeted therapy;
(3) monitor: ultra sonic imaging transducer gathers the target area image after treatment again, signal is turned back to signal processing center, calculate the target area image gray value after treatment, then according to above-mentioned original gray value, calculate the ultrasound grayscale changing value of target area image before and after treatment;
(4) diagnose: step (3) result is fed back to main control centre by signal processing center, if when above-mentioned ultrasound grayscale changing value is less than or equal to standard value, then stop treatment; If when being greater than standard value, then repeat above-mentioned steps (2) and (3), until when described ultrasound grayscale changing value is less than or equal to standard value, stop treatment.
As preferably, the standard value in described step (4) is 3-5 gray value.
In the present invention, ultrasonic therapy energy converter utilizes the concentration ultrasonic of low frequency, high energy to carry out fixed point irradiation to target tumor tissue, utilize hyperacoustic heat effect, realize microbubble thermal expansion or the temperature sensitive contrast agent object at target tumor tissue place directional controlled release medicine or gene.And in conjunction with ultra sonic imaging transducer, realize the integration of ultrasonic imaging and treatment, greatly optimize the method for ultrasonic therapeutic tumor.
Use before and after micro air bubble ultrasonic contrast medium, target tissue image gray-scale level can change, if image gray-scale level contrast difference is less than or equal to standard value before and after triggering, then illustrates and reaches therapeutic effect.
Gray value is evenly distributed in 0-255 spatial dimension by the present invention, and 0 represents entirely black, and 255 represent complete white;
Technique effect: relative to prior art, ultrasonic medical system of the present invention can complete the overall process of image supervisory control and treatment.And this system is not only applicable to utilize thermal effect of ultrasound controlled release to carry the temperature sensitive ultrasonic microbubble contrast of gene or medicine, is also applicable to blank microbubble contrast and blocks tumor vessel, be widely used, and greatly optimize the method for ultrasonic therapeutic tumor.In addition, the present invention also has the following advantages:
(1) system of tumor is treated in ultra sonic imaging provided by the present invention and ultrasonic therapeutic technological incorporation, for oncotherapy provides a kind of safer, effective non-invasive treatment methods.
(2) in present system, ultra sonic imaging transducer and ultrasonic triggered transducer carry out rotation work, wherein ultra sonic imaging transducer has good anatomical structure stationkeeping ability to tissue, can carry out preoperative accurately, guide in art, and can can't harm, the change of target area tissue in real-time monitor treatment process, improves the safety for the treatment of.
(3) because the sound intensity of ultrasonic triggered transducer can be good at triggering temperature sensitive acoustic contrast agent release medicine or gene, so the present invention is also a kind of ultrasonography monitoring and target controlling and releasing system.For superficial tumor, adopt thermal effect of ultrasound to trigger and there is temperature sensitive effect and the acoustic contrast agent carrying gene or medicine, systemic chemotherapy is changed into topical chemotherapy, reduce chemotherapeutics to the damage of human normal tissue.Thermal effect of ultrasound has effect of enhanced sensitivity to chemotherapy simultaneously, and for tumor patient, especially, old age, patient, was a kind of well therapeutic modality.
(4) the present invention is easy to operate, is easy to promote, simultaneously can repetitive therapy.In addition, native system avirulence and side effect, can also be used for carcinoid treatment.
Accompanying drawing explanation
Fig. 1 is the structural representation of ultrasonic medical system of the present invention;
Fig. 2 is transducer architecture schematic diagram of the present invention;
Fig. 3 is the focusing time delay schematic diagram of the ultrasonic triggered transducer of the present invention;
Fig. 4 is the functional block diagram of present system;
Fig. 5 is present system ultrasonic therapeutic order diagram;
Fig. 6 is the workflow diagram utilizing present system to treat tumor.
Detailed description of the invention
Technical solution of the present invention is further described below in conjunction with accompanying drawing.
Embodiment 1: ultrasonic medical system
A kind of ultrasonic medical system, is shown in accompanying drawing 1, comprise be connected successively main control centre, supersonic generator, diagnosis and treatment integrated probe system and signal processing center;
Probe system is shown in accompanying drawing 2, and comprising can rotation work and the ultrasonic triggered transducer be independent of each other and ultra sonic imaging transducer; One end, described signal processing center is connected with probe, and one end is connected with main control centre;
Main control centre controls supersonic generator and launches ultrasound wave, through ultrasonic triggered transducer or ultra sonic imaging transducer, and input probe; The signal of probe detection can turn back to signal processing center, after this is by signal processing, feed back to main control centre.
Described ultrasonic triggered transducer and ultra sonic imaging transducer linear array structure, their one end is connected with supersonic generator, and the other end is connected with probe;
Described ultra sonic imaging transducer is arranged on the centre of two ultrasonic triggered transducer, and by the angle between the ultrasonic triggered transducer of adjustment and ultra sonic imaging transducer and distance, ensure that the focal regions that ultrasonic triggered transducer produces drops in the video picture visual field of ultra sonic imaging transducer.
For the focusing time delay of ultrasonic triggered transducer, see accompanying drawing 3, because edge array element 64 is apart from farthest, therefore being excited at first, is then slightly closer array element 63, then after be array element 62, by that analogy, what be finally excited is array element 1, realizes the depth of focus by every centimetre of one grade of continuously adjustabe.
The technical parameter of described ultrasonic triggered transducer is as follows:
Transducer length 20 ~ 60mm, wide 0.5 ~ 1.2cm; Array number: 128 array elements; Array element distance 0.1 ~ 0.6mm; Focal length: 2 ~ 6cm; Transducer operating frequency: 0.8 ~ 1.2MHz; Focal shape: elliposoidal; The focal regions center sound intensity: 0.5 ~ 2.5W/cm
2, acoustic pressure: 120 ~ 300Kpa.
The technical parameter of ultra sonic imaging transducer is as follows:
Array number: 128 array elements; Transducer operating frequency: 5 ~ 10MHz; Investigation depth :≤6cm; The sound intensity (ISPTA): 0.01 ~ 0.03W/cm
2.
Embodiment 2: ultrasonic medical systematic treating tumor
Utilize the method for above-mentioned ultrasonic medical systematic treating tumor, comprise the steps:
(1) detect: main control centre controls ultra sonic imaging transducer and launches ultrasonic by probe to knub position, imaging is carried out to detecting location, and the position injection microbubble contrast determined, by fixed point radiation, utilize the effect of ultrasonic radiation force, the fixed point realizing microbubble contrast is assembled.And then, signal is turned back to signal processing center, recognize to find target tumor tissue to image, also referred to as target area, calculate original gray value;
(2) treat: main control centre controls ultrasonic triggered transducer and launches focus supersonic by probe to target area, because the energy of focus supersonic is higher, to the microbubble heating assembled, microbubble is expanded; Or make temperature sensitive microbubble release tumor medicine or the gene after thermal effect of ultrasound assembled; Final blocking-up tumor neogenetic blood vessels or improve the absorption of tumor tissues to medicine and gene, reaches the object of neoplasm targeted therapy;
(3) monitor: ultra sonic imaging transducer gathers the target area image after treatment again, signal is turned back to signal processing center, calculate the target area image gray value after treatment, then according to above-mentioned original gray value, calculate the ultrasound grayscale changing value of target area image before and after treatment;
(4) diagnose: step (3) result is fed back to main control centre by signal processing center, if when above-mentioned ultrasound grayscale changing value is less than or equal to standard value, then stop treatment; If when being greater than standard value, then repeat above-mentioned steps (2) and (3), until when described ultrasound grayscale changing value is less than or equal to standard value, stop treatment.
As preferably, the standard value in described step (4) is 3-5 gray value.
Claims (6)
1. a ultrasonic medical system, is characterized in that, comprise be connected successively main control centre, supersonic generator, diagnosis and treatment integrated probe system and signal processing center;
Described probe system comprises can rotation work and the ultrasonic triggered transducer be independent of each other and ultra sonic imaging transducer; One end, described signal processing center is connected with probe, and one end is connected with main control centre;
Described main control centre controls supersonic generator and launches ultrasound wave, through ultrasonic triggered transducer or ultra sonic imaging transducer input probe; The signal of probe detection can turn back to signal processing center, after this is by signal processing, feed back to main control centre.
2. ultrasonic medical system according to claim 1, is characterized in that, described ultrasonic triggered transducer, ultra sonic imaging transducer linear array structure, and their one end is connected with supersonic generator, and the other end is connected with probe.
3. ultrasonic medical system according to claim 1, it is characterized in that, described ultra sonic imaging transducer is arranged on the centre of two ultrasonic triggered transducer, and by the angle between the ultrasonic triggered transducer of adjustment and ultra sonic imaging transducer and distance, ensure that the focal regions that ultrasonic triggered transducer produces drops in the video picture visual field of ultra sonic imaging transducer.
4. ultrasonic medical system according to claim 1, is characterized in that, the technical parameter of described ultrasonic triggered transducer is as follows:
Transducer length 20 ~ 60mm, wide 0.5 ~ 1.2cm; Array number: 128 array elements; Array element distance 0.1 ~ 0.6mm; Focal length: 2 ~ 6cm; Transducer operating frequency: 0.8 ~ 1.2MHz; Focal shape: elliposoidal; The focal regions center sound intensity: 0.5 ~ 2.5W/cm
2, acoustic pressure: 120 ~ 300Kpa.
5. utilize the method for ultrasonic medical systematic treating tumor described in any one of claim 1-4, it is characterized in that, comprise the steps:
(1) detect: main control centre controls ultra sonic imaging transducer and launches ultrasound wave by probe to knub position, then signal is turned back to signal processing center, recognize to find target tumor tissue to image, also referred to as target area, calculate original gray value;
(2) treat: main control centre controls ultrasonic triggered transducer and launches focus supersonic by probe to target area, because the energy of focus supersonic is higher, to the microbubble heating assembled in target area, microbubble is expanded, or to temperature sensitive microbubble release tumor medicine or the gene after ultrasonic temperature effect assembled;
(3) monitor: ultra sonic imaging transducer gathers the target area image after treatment again, signal is turned back to signal processing center, calculate the target area image gray value after treatment, then according to above-mentioned original gray value, calculate the ultrasound grayscale changing value of target area image before and after treatment;
(4) diagnose: step (3) result is fed back to main control centre by signal processing center, if when above-mentioned ultrasound grayscale changing value is less than or equal to standard value, then stop treatment; If when being greater than standard value, then repeat above-mentioned steps (2) and (3), until when described ultrasound grayscale changing value is less than or equal to standard value, stop treatment.
6. the method for the treatment of tumor according to claim 5, is characterized in that, the standard value in described step (4) is 3-5 gray value.
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Cited By (6)
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| CN105426024A (en) * | 2015-11-25 | 2016-03-23 | 吉林大学 | Ultrasonic focus based haptic feedback system and method |
| CN109717900A (en) * | 2019-01-02 | 2019-05-07 | 飞依诺科技(苏州)有限公司 | Assisting in diagnosis and treatment method, apparatus and storage medium |
| CN111387941A (en) * | 2020-03-16 | 2020-07-10 | 重庆医科大学 | Sound-light integrated imaging and treatment system and method |
| CN112566694A (en) * | 2018-05-25 | 2021-03-26 | 卡尔迪亚韦弗公司 | Ultrasound treatment device comprising means for imaging cavitation bubbles |
| CN113116296A (en) * | 2020-01-13 | 2021-07-16 | 香港城市大学深圳研究院 | Photoacoustic and ultrasonic collaborative diagnosis and treatment system |
| CN117398122A (en) * | 2023-09-07 | 2024-01-16 | 深圳高性能医疗器械国家研究院有限公司 | Ultrasonic diagnosis and treatment equipment and control method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111387941A (en) * | 2020-03-16 | 2020-07-10 | 重庆医科大学 | Sound-light integrated imaging and treatment system and method |
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